ketanserin has been researched along with Innate Inflammatory Response in 16 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on young (3 months) and old (9 months) male Wistar rats with experimental liver cirrhosis." | 8.12 | Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis. ( Afanas'ev, SA; Dygai, АМ; Ermakova, NN; Kogai, LV; Pakhomova, AV; Pan, ES; Pershina, ОV; Putrova, ОD; Rebrova, ТY; Sandrikina, LА; Skurikhin, ЕG; Zhukova, МА, 2022) |
| "We investigated effects of topical application of ketanserin, a 5-HT2A receptor antagonist, on hyperalgesia and edema in the arthritic rat, a chronic pain model with inflammation." | 7.73 | Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. ( Hong, Y; Ji, H; Wei, H, 2006) |
| "The effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on young (3 months) and old (9 months) male Wistar rats with experimental liver cirrhosis." | 4.12 | Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis. ( Afanas'ev, SA; Dygai, АМ; Ermakova, NN; Kogai, LV; Pakhomova, AV; Pan, ES; Pershina, ОV; Putrova, ОD; Rebrova, ТY; Sandrikina, LА; Skurikhin, ЕG; Zhukova, МА, 2022) |
| "We investigated effects of topical application of ketanserin, a 5-HT2A receptor antagonist, on hyperalgesia and edema in the arthritic rat, a chronic pain model with inflammation." | 3.73 | Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. ( Hong, Y; Ji, H; Wei, H, 2006) |
| "The ketanserin treatment also reduced the repeated inflammation-induced expression of protein kinase gamma (PKCγ) in the membrane of spinal dorsal horn neurons and increased PKCγ protein level in the cytosol." | 1.43 | Blockade of 5-HT2A receptors at the site of inflammation inhibits activation of spinal dorsal horn neurons in rats. ( Cai, Q; Hong, Y; Hu, W; Wang, D; Zhang, Y, 2016) |
| "injection abolished carrageenan-evoked hyperalgesia at the doses, at which the drugs failed to alter the hypersensitivity when they were given alone." | 1.39 | Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. ( Hong, Y; Wang, D; Zhou, X, 2013) |
| "Pretreatment with ketanserin significantly attenuated these effects." | 1.36 | Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. ( le Grand, SM; Srikiatkhachorn, A; Supornsilpchai, W, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Pan, ES | 1 |
| Pakhomova, AV | 1 |
| Ermakova, NN | 1 |
| Afanas'ev, SA | 1 |
| Rebrova, ТY | 1 |
| Zhukova, МА | 1 |
| Sandrikina, LА | 1 |
| Putrova, ОD | 1 |
| Kogai, LV | 1 |
| Pershina, ОV | 1 |
| Dygai, АМ | 1 |
| Skurikhin, ЕG | 1 |
| Wang, D | 2 |
| Zhou, X | 1 |
| Hong, Y | 6 |
| Vellinga, NA | 1 |
| Veenstra, G | 1 |
| Scorcella, C | 1 |
| Koopmans, M | 1 |
| van Roon, EN | 1 |
| Ince, C | 1 |
| Boerma, EC | 1 |
| Huang, BQ | 1 |
| Wu, B | 1 |
| Hu, W | 2 |
| Voronova, IP | 1 |
| Khramova, GM | 1 |
| Kulikova, EA | 1 |
| Petrovskii, DV | 1 |
| Bazovkina, DV | 1 |
| Kulikov, AV | 1 |
| Zhang, Y | 1 |
| Cai, Q | 2 |
| Huang, J | 2 |
| Chen, Y | 1 |
| Supornsilpchai, W | 1 |
| le Grand, SM | 1 |
| Srikiatkhachorn, A | 1 |
| Fan, Y | 1 |
| Jia, Y | 1 |
| Ji, H | 1 |
| Wei, H | 1 |
| Hechtman, HB | 1 |
| Valeri, CR | 1 |
| Shepro, D | 1 |
| Doak, GJ | 1 |
| Sawynok, J | 1 |
| Tozawa, Y | 1 |
| Matsushima, K | 1 |
| Sufka, KJ | 1 |
| Schomburg, FM | 1 |
| Giordano, J | 1 |
| Belch, JJ | 1 |
| Parmentier, HK | 1 |
| de Vries, C | 1 |
| Ruitenberg, EJ | 1 |
| Van Loveren, H | 1 |
3 reviews available for ketanserin and Innate Inflammatory Response
| Article | Year |
|---|---|
5-HT2A receptors control body temperature in mice during LPS-induced inflammation via regulation of NO production.
Topics: Amphetamines; Animals; Body Temperature; Brain; Cytokines; Inflammation; Ketanserin; Lipopolysacchar | 2016 |
Role of humoral mediators in adult respiratory distress syndrome.
Topics: Animals; Arachidonic Acids; Chemotaxis, Leukocyte; Chromones; Dogs; Guinea Pigs; Humans; Hypertensio | 1984 |
Raynaud's phenomenon.
Topics: Antibody Formation; Blood Vessels; Endothelium, Vascular; Fatty Acids, Essential; Humans; Inflammati | 1989 |
1 trial available for ketanserin and Innate Inflammatory Response
| Article | Year |
|---|---|
Effects of ketanserin on microcirculatory alterations in septic shock: An open-label pilot study.
Topics: Adult; Aged; Capillaries; Female; Hemodynamics; Humans; Hypotension; Inflammation; Ketanserin; Male; | 2015 |
12 other studies available for ketanserin and Innate Inflammatory Response
| Article | Year |
|---|---|
Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis.
Topics: Animals; Hepatocytes; Inflammation; Ketanserin; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimenta | 2022 |
Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats.
Topics: Analgesics; Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Hy | 2013 |
[Effects of blockade of 5-HT2A receptors in inflammatory site on complete Freund's adjuvant-induced chronic hyperalgesia and neuropeptide Y expression in the spinal dorsal horn in rats].
Topics: Animals; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Ketanserin | 2015 |
Blockade of 5-HT2A receptors at the site of inflammation inhibits activation of spinal dorsal horn neurons in rats.
Topics: Animals; Carrageenan; Gene Expression Regulation; Inflammation; Ketanserin; Male; NADH Dehydrogenase | 2016 |
Treatment with ketanserin produces opioid-mediated hypoalgesia in the late phase of carrageenan-induced inflammatory hyperalgesia in rats.
Topics: Analgesia; Animals; Carrageenan; Disease Models, Animal; Hot Temperature; Hyperalgesia; Inflammation | 2009 |
Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cerebral Cortex; Cerebrovascular Circulation; Dise | 2010 |
Antagonism of 5-HT(2A) receptors inhibits the expression of pronociceptive mediator and enhances endogenous opioid mechanism in carrageenan-induced inflammation in rats.
Topics: Animals; beta-Endorphin; Calcitonin Gene-Related Peptide; Carrageenan; Ganglia, Spinal; Inflammation | 2011 |
Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats.
Topics: Administration, Topical; Analysis of Variance; Animals; Arthritis, Experimental; Behavior, Animal; C | 2006 |
Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes.
Topics: Animals; Edema; Formaldehyde; Indoles; Inflammation; Ketanserin; Male; Pain; Propranolol; Rats; Rats | 1997 |
Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atrial Natriuretic Factor; Catecholamin | 2002 |
Receptor mediation of 5-HT-induced inflammation and nociception in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Ketanserin; M | 1992 |
Involvement of serotonin in intestinal mastocytopoiesis and inflammation during a Trichinella spiralis infection in mice.
Topics: Animals; Cell Division; Cells, Cultured; Female; Hematopoiesis; Inflammation; Intestinal Diseases; I | 1987 |