ketanserin has been researched along with Hypoxia in 40 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension." | 7.69 | Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs. ( Delcroix, M; Leeman, M; Maggiorini, M; Naeije, R; Wauthy, P, 1995) |
| "The pure and selective serotonin blocking agent ketanserin (5-HT2 receptor blocker) was used to evaluate a possible role for serotonin as a mediator of the pulmonary vasoconstrictor response to alveolar hypoxia." | 7.67 | The effect of ketanserin on hypoxia-induced vasoconstriction in isolated lungs. ( Bjertnaes, L; Helgesen, KG, 1986) |
| " The bradycardia appeared to be mediated to some extent by 5-HT(2) receptors, as methysergide, a non-selective 5-HT(1/2) receptor antagonist, and ketanserin, a 5-HT(2) receptor antagonist, attenuated the response." | 3.76 | Cardiovascular and respiratory reflexes of the gulf toadfish (Opsanus beta) during acute hypoxia. ( Gilmour, KM; McDonald, MD; Perry, SF; Walsh, PJ, 2010) |
| " We show that repeated obstructive apneas disrupt vagal feedback and trigger LTF of hypoglossal motoneuron activity and genioglossus muscle tone." | 3.76 | Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback. ( Duffin, J; Peever, J; Tadjalli, A, 2010) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| " During exposure to hypoxia (10% O2 for 2 weeks), the animals received one of the specific 5-HTT inhibitors citalopram and fluoxetine (10 mg/kg/day), the selective 5-HT1B/1D receptor antagonist GR127935 (2 and 10 mg/kg/day), or the 5-HT2A receptor antagonist ketanserin (2 mg/kg/day)." | 3.72 | Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. ( Adnot, S; Eddahibi, S; Hamon, M; Marcos, E; Nosjean, A; Pham, MH; Raffestin, B, 2003) |
| "We hypothesized that the 5-hydroxytryptamine (5-HT) active drugs ketanserin and 5-carboxamidotryptamine (5-CT) would modulate time-dependent hypoxic phrenic and hypoglossal responses, including 1) short-term hypoxic response, 2) posthypoxia frequency decline (PHFD), and 3) long-term facilitation (LTF) of respiratory motor output." | 3.70 | Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine. ( Kinkead, R; Mitchell, GS, 1999) |
| "There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension." | 3.69 | Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs. ( Delcroix, M; Leeman, M; Maggiorini, M; Naeije, R; Wauthy, P, 1995) |
| " The role of inositol 1,4,5-trisphosphate (InsP3) in the reduced vascular responsiveness to 5-hydroxytryptamine (5-HT) caused by chronic hypoxia was examined in uterine arteries obtained from normoxic (control) and chronically hypoxic pregnant sheep (approximately 140 days gestation) maintained at high altitude (3820 m; arterial PO2, 60 mmHg) from 30 days gestation." | 3.69 | Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near-term pregnant sheep. ( Hu, XQ; Zhang, L, 1997) |
| "The 5-HT antagonists ketanserin, mianserin, methysergide, and cyproheptadine and the 5-HT uptake inhibitors fluoxetine and zimeldine were evaluated for their ability to protect against an hypoxia-induced performance deficit in a passive avoidance (PA) task." | 3.67 | Manipulation of serotonin protects against an hypoxia-induced deficit of a passive avoidance response in rats. ( DeNoble, VJ; Spencer, KR; Strek, KF, 1989) |
| "The pure and selective serotonin blocking agent ketanserin (5-HT2 receptor blocker) was used to evaluate a possible role for serotonin as a mediator of the pulmonary vasoconstrictor response to alveolar hypoxia." | 3.67 | The effect of ketanserin on hypoxia-induced vasoconstriction in isolated lungs. ( Bjertnaes, L; Helgesen, KG, 1986) |
| "Intravenous injection of ethchlorvynol (ECV) leads to hypoxemia and a permeability pulmonary edema." | 3.67 | Indomethacin and ketanserin block ethchlorvynol-induced hypoxemia in dogs. ( Glauser, FL; Millen, JE, 1986) |
| "Serotonin can induce pulmonary hypertension, hypoxia and bronchoconstriction, and ketanserin has been shown to reverse these effects on various experimental models of acute respiratory failure." | 3.67 | Effects of serotonin inhibition in air embolism in dogs. ( Domb, M; Goldstein, J; Lignan, H; Vincent, JL, 1988) |
| "The effects of the serotonin receptor blocker, ketanserin, were studied in a porcine Pseudomonas adult respiratory distress syndrome model." | 3.67 | Serotonin receptor blockade improves cardiac output and hypoxia in porcine ARDS. ( Kellum, JM; Kuemmerle, JF; Sielaff, TD; Sugerman, HJ; Tatum, JL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (22.50) | 18.7374 |
| 1990's | 9 (22.50) | 18.2507 |
| 2000's | 11 (27.50) | 29.6817 |
| 2010's | 9 (22.50) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perim, RR | 1 |
| Kubilis, PS | 1 |
| Seven, YB | 1 |
| Mitchell, GS | 5 |
| Mendonça-Junior, BA | 1 |
| V Fernandes, M | 1 |
| Zoccal, DB | 1 |
| Andrzejewski, K | 1 |
| Kaczyńska, K | 1 |
| Zaremba, M | 1 |
| Yokoyama, T | 1 |
| Nakamuta, N | 1 |
| Kusakabe, T | 1 |
| Yamamoto, Y | 1 |
| Guner, I | 1 |
| Sahin, G | 1 |
| Yelmen, NK | 1 |
| Aksu, U | 1 |
| Oruc, T | 1 |
| Yildirim, Z | 1 |
| Cao, Y | 1 |
| Liu, C | 1 |
| Ling, L | 2 |
| McDonald, MD | 1 |
| Gilmour, KM | 1 |
| Walsh, PJ | 1 |
| Perry, SF | 1 |
| Budzinska, K | 1 |
| Tadjalli, A | 1 |
| Duffin, J | 1 |
| Peever, J | 1 |
| Anju, TR | 1 |
| Korah, PK | 1 |
| Jayanarayanan, S | 1 |
| Paulose, CS | 1 |
| Regan, KS | 1 |
| Jonz, MG | 1 |
| Wright, PA | 1 |
| Goyal, R | 1 |
| Papamatheakis, DG | 1 |
| Loftin, M | 1 |
| Vrancken, K | 1 |
| Dawson, AS | 1 |
| Osman, NJ | 1 |
| Blood, AB | 1 |
| Pearce, WJ | 1 |
| Longo, LD | 1 |
| Wilson, SM | 1 |
| Ramirez, M | 1 |
| Gallego-Martin, T | 1 |
| Olea, E | 1 |
| Rocher, A | 1 |
| Obeso, A | 1 |
| Gonzalez, C | 1 |
| Marcos, E | 1 |
| Adnot, S | 1 |
| Pham, MH | 1 |
| Nosjean, A | 1 |
| Raffestin, B | 1 |
| Hamon, M | 1 |
| Eddahibi, S | 1 |
| McGuire, M | 1 |
| Zhang, Y | 1 |
| White, DP | 1 |
| Jacono, FJ | 1 |
| Peng, YJ | 1 |
| Kumar, GK | 1 |
| Prabhakar, NR | 1 |
| Golder, FJ | 1 |
| Chang, CP | 1 |
| Chen, SH | 1 |
| Lin, MT | 1 |
| St-John, WM | 1 |
| Leiter, JC | 1 |
| Kirby, GC | 1 |
| McQueen, DS | 1 |
| Naeije, R | 1 |
| Wauthy, P | 1 |
| Maggiorini, M | 1 |
| Leeman, M | 1 |
| Delcroix, M | 1 |
| Katsura, M | 1 |
| Iino, T | 1 |
| Kuriyama, K | 1 |
| Hu, XQ | 1 |
| Zhang, L | 1 |
| Egermayer, P | 1 |
| Town, GI | 1 |
| Peacock, AJ | 1 |
| Kinkead, R | 1 |
| Herman, JK | 3 |
| O'Halloran, KD | 3 |
| Bisgard, GE | 3 |
| Fuller, DD | 1 |
| Zabka, AG | 1 |
| Baker, TL | 1 |
| Kagami, Y | 1 |
| Shigenobu, S | 1 |
| Watanabe, S | 1 |
| DeNoble, VJ | 3 |
| Schrack, LM | 1 |
| Reigel, AL | 1 |
| DeNoble, KF | 2 |
| Spencer, KR | 2 |
| Strek, KF | 1 |
| Van Nueten, JM | 1 |
| Janssens, WJ | 1 |
| Vanhoutte, PM | 1 |
| Demling, RH | 1 |
| Wong, C | 1 |
| Fox, R | 1 |
| Hechtman, H | 1 |
| Huval, W | 1 |
| Hamet, A | 1 |
| Král, B | 1 |
| Cernohorský, D | 1 |
| Helgesen, KG | 1 |
| Bjertnaes, L | 1 |
| Millen, JE | 1 |
| Glauser, FL | 1 |
| Vincent, JL | 1 |
| Goldstein, J | 1 |
| Domb, M | 1 |
| Lignan, H | 1 |
| Sielaff, TD | 1 |
| Kellum, JM | 1 |
| Sugerman, HJ | 1 |
| Kuemmerle, JF | 1 |
| Tatum, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurovascular Mechanisms of Intermittent Hypoxia Induced Neural Plasticity[NCT05183113] | 43 participants (Actual) | Interventional | 2019-05-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketanserin and Hypoxia
| Article | Year |
|---|---|
Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension.
Topics: Blood Platelet Disorders; Collagen Diseases; Humans; Hypertension, Portal; Hypertension, Pulmonary; | 1999 |
Serotonin and vascular reactivity.
Topics: Animals; Blood Platelets; Calcium; Cold Temperature; Electric Stimulation; Hypoxia; Ketanserin; Lido | 1985 |
38 other studies available for ketanserin and Hypoxia
| Article | Year |
|---|---|
Hypoxia-induced hypotension elicits adenosine-dependent phrenic long-term facilitation after carotid denervation.
Topics: Adenosine; Animals; Arterial Pressure; Blood Gas Analysis; Carotid Body; Denervation; Hypotension; H | 2020 |
Acute intermittent hypoxia evokes ventilatory long-term facilitation and active expiration in unanesthetized rats.
Topics: Animals; Disease Models, Animal; Hypoxia; Ketanserin; Male; Pulmonary Ventilation; Rats; Rats, Sprag | 2021 |
Serotonergic system in hypoxic ventilatory response in unilateral rat model of Parkinson's disease.
Topics: Amphetamines; Animals; Brain Stem; Corpus Striatum; Hypoxia; Ketanserin; Male; Organ Specificity; Ox | 2017 |
Sympathetic regulation of vascular tone via noradrenaline and serotonin in the rat carotid body as revealed by intracellular calcium imaging.
Topics: Actins; Animals; Antigens; Blood Vessels; Calcium; Carotid Body; Dopamine beta-Hydroxylase; Hypoxia; | 2015 |
Intracerebroventricular serotonin reduces the degree of acute hypoxic ventilatory depression in peripherally chemodenervated rabbits.
Topics: Acute Disease; Animals; Carbon Dioxide; Chloralose; Hydrogen-Ion Concentration; Hypoxia; Injections, | 2008 |
Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats.
Topics: Anesthesia; Animals; Blood Gas Analysis; Chronic Disease; Dizocilpine Maleate; Excitatory Amino Acid | 2010 |
Cardiovascular and respiratory reflexes of the gulf toadfish (Opsanus beta) during acute hypoxia.
Topics: Analysis of Variance; Animals; Batrachoidiformes; Bradycardia; Cardiovascular System; Disease Models | 2010 |
Serotoninergic modulation of cortical and respiratory responses to episodic hypoxia.
Topics: Amphetamines; Animals; Blood Pressure; Cerebral Cortex; Electroencephalography; Hypoxia; Ketanserin; | 2009 |
Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback.
Topics: Adrenergic alpha-1 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; A | 2010 |
Enhanced brain stem 5HT₂A receptor function under neonatal hypoxic insult: role of glucose, oxygen, and epinephrine resuscitation.
Topics: Animals; Animals, Newborn; Binding, Competitive; Brain Stem; Epinephrine; Glucose; Hypoxia; Hypoxia- | 2011 |
Neuroepithelial cells and the hypoxia emersion response in the amphibious fish Kryptolebias marmoratus.
Topics: Animals; Chemoreceptor Cells; Cyprinodontiformes; Gills; Hexamethonium; Hypoxia; Immunohistochemistr | 2011 |
Long-term maternal hypoxia: the role of extracellular Ca2+ entry during serotonin-mediated contractility in fetal ovine pulmonary arteries.
Topics: Animals; Calcium; Female; Fetus; Hypoxia; In Vitro Techniques; Ketanserin; Pregnancy; Pulmonary Arte | 2011 |
Serotonin dynamics and actions in the rat carotid body: preliminary findings.
Topics: Animals; Carotid Body; Female; Hypoxia; Ketanserin; Male; Rats; Rats, Wistar; Serotonin | 2012 |
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.
Topics: Analysis of Variance; Animals; Carrier Proteins; Chronic Disease; Citalopram; Disease Models, Animal | 2003 |
Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats.
Topics: Animals; Chronic Disease; Clozapine; Hypoxia; Ketanserin; Male; Methysergide; Rats; Rats, Sprague-Da | 2004 |
Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor.
Topics: Action Potentials; Animals; Carotid Body; Chromatography, High Pressure Liquid; Dopamine; Electroche | 2005 |
Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury.
Topics: Animals; Arteries; Blood Gas Analysis; Cell Count; Chronic Disease; Diagnostic Imaging; Hydrogen-Ion | 2005 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Am | 2008 |
Effects of the antagonists MDL 72222 and ketanserin on responses of cat carotid body chemoreceptors to 5-hydroxytryptamine.
Topics: Action Potentials; Animals; Carotid Body; Cats; Chemoreceptor Cells; Domperidone; Dopamine; Electrop | 1984 |
Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs.
Topics: Animals; Dogs; Fenfluramine; Hypertension, Pulmonary; Hypoxia; Ketanserin; Pulmonary Artery; Pulmona | 1995 |
(+-)-Methyl-2,3,3a,4-tetrahydro-1H-indolo [3,2,1-de] [1,5] naphthyridine-6-carboxylate monohydrochloride facilitates phosphatidylinositol hydrolysis: possible involvement of muscarinic and nonmuscarinic mechanisms.
Topics: Animals; Atropine; Carbachol; Cerebral Cortex; Guanosine Triphosphate; Hypoxia; In Vitro Techniques; | 1993 |
Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near-term pregnant sheep.
Topics: Animals; Female; Hypoxia; Inositol 1,4,5-Trisphosphate; Ketanserin; Muscle, Smooth, Vascular; Phenox | 1997 |
Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine.
Topics: Animals; Hypoxia; Ketanserin; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Respiratory Me | 1999 |
Methysergide augments the acute, but not the sustained, hypoxic ventilatory response in goats.
Topics: Acclimatization; Animals; Blood Pressure; Carbon Dioxide; Female; Goats; Heart Rate; Hypoxia; Ketans | 1999 |
Serotonin and the hypoxic ventilatory response in awake goats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acclimatization; Animals; Carotid Body; Chemoreceptor Cells; | 2000 |
Effect of 8-OH DPAT and ketanserin on the ventilatory acclimatization to hypoxia in awake goats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Physiological; Analysis of Variance; Animals; Bl | 2001 |
Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.
Topics: Animals; Hypoxia; Ketanserin; Male; Neuronal Plasticity; Phrenic Nerve; Rats; Rats, Sprague-Dawley; | 2001 |
Neuroprotective effect of 5-HT3 receptor antagonist on ischemia-induced decrease in CA1 field potential in rat hippocampal slices.
Topics: 5,7-Dihydroxytryptamine; Animals; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compoun | 1992 |
Visual recognition memory in squirrel monkeys: effects of serotonin antagonists on baseline and hypoxia-induced performance deficits.
Topics: Animals; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Hypoxia; Ketanserin; Male; | 1991 |
Protection against hypoxia-induced passive avoidance deficits: interactions between DuP 996 and ketanserin.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Drug Interactions; Hypoxia; Indoles; Ketanserin; Mal | 1991 |
Manipulation of serotonin protects against an hypoxia-induced deficit of a passive avoidance response in rats.
Topics: Animals; Avoidance Learning; Cyproheptadine; Dose-Response Relationship, Drug; Fluoxetine; Hypoxia; | 1989 |
Relationship of increased lung serotonin levels to endotoxin-induced pulmonary hypertension in sheep. Effect of a serotonin antagonist.
Topics: Animals; Blood Pressure; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Hypoxia; Ketanserin; | 1985 |
Comparative effects of oxygen, nifedipine and ketanserin in hypoxic pulmonary hypertension.
Topics: Adult; Carbon Dioxide; Cardiac Output; Female; Heart Rate; Humans; Hypertension, Pulmonary; Hypoxia; | 1985 |
The effect of ketanserin on hypoxia-induced vasoconstriction in isolated lungs.
Topics: Animals; Hypoxia; In Vitro Techniques; Ketanserin; Lung; Perfusion; Piperidines; Pulmonary Circulati | 1986 |
Indomethacin and ketanserin block ethchlorvynol-induced hypoxemia in dogs.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs; Ethchlorvynol; Hypoxia; Indomethacin; | 1986 |
Effects of serotonin inhibition in air embolism in dogs.
Topics: Animals; Blood Pressure; Dogs; Embolism, Air; Hypertension, Pulmonary; Hypoxia; Ketanserin; Serotoni | 1988 |
Serotonin receptor blockade improves cardiac output and hypoxia in porcine ARDS.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Histamine Antagonists; Hypoxia; Ket | 1987 |