ketanserin has been researched along with Glioma in 7 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA), which has demonstrated efficacy in the treatment of bipolar disorder, has been shown to alter components of the phosphoinositide (PI) signaling cascade and to increase gene expression mediated by the transcription factor activator protein 1 (AP-1)." | 5.32 | Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells. ( Burke, T; Hensler, JG; Javors, M; Siafaka-Kapadai, A; Sullivan, NR, 2004) |
| "5-Hydroxytryptamine (serotonin or 5-HT) stimulated the incorporation of 32Pi into phosphatidylinositol (PI) but not into polyphosphoinositides in C6 glioma cells with an EC50 of 1." | 3.67 | Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells. ( Ananth, US; Hauser, G; Leli, U, 1987) |
| "Valproic acid (VPA), which has demonstrated efficacy in the treatment of bipolar disorder, has been shown to alter components of the phosphoinositide (PI) signaling cascade and to increase gene expression mediated by the transcription factor activator protein 1 (AP-1)." | 1.32 | Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells. ( Burke, T; Hensler, JG; Javors, M; Siafaka-Kapadai, A; Sullivan, NR, 2004) |
| "Alniditan is a new migraine-abortive agent." | 1.29 | Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamin ( Gommeren, W; Haegeman, G; Heylen, L; Lesage, AS; Leysen, JE; Luyten, WH; Schotte, A; Van de Weyer, I; Van Gompel, P; Vanhoenacker, P; Wouters, R, 1996) |
| " The dose-response curve for 5-HT was shifted 9-fold to the left compared to controls, and the Vmax value was also significantly enhanced." | 1.29 | Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells. ( Kagaya, A; Mikuni, M; Muraoka, S; Saitoh, K; Takahashi, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leysen, JE | 1 |
| Gommeren, W | 1 |
| Heylen, L | 1 |
| Luyten, WH | 1 |
| Van de Weyer, I | 1 |
| Vanhoenacker, P | 1 |
| Haegeman, G | 1 |
| Schotte, A | 1 |
| Van Gompel, P | 1 |
| Wouters, R | 1 |
| Lesage, AS | 1 |
| Sullivan, NR | 1 |
| Burke, T | 1 |
| Siafaka-Kapadai, A | 1 |
| Javors, M | 1 |
| Hensler, JG | 1 |
| Muraoka, S | 1 |
| Mikuni, M | 1 |
| Kagaya, A | 2 |
| Saitoh, K | 1 |
| Takahashi, K | 1 |
| Motohashi, N | 1 |
| Kugaya, A | 1 |
| Yamaji, T | 1 |
| Hayashi, T | 1 |
| Okamoto, Y | 1 |
| Shinno, H | 1 |
| Takebayashi, M | 1 |
| Uchitomi, Y | 1 |
| Yamawaki, S | 1 |
| Elliott, JM | 1 |
| Newberry, NR | 1 |
| Cholewinski, AJ | 1 |
| Bartrup, JT | 1 |
| Briddon, SJ | 1 |
| Carey, JE | 1 |
| Flanigan, TP | 1 |
| Newton, RA | 1 |
| Phipps, SL | 1 |
| Reavley, AC | 1 |
| Thomas, EA | 1 |
| Matli, JR | 1 |
| Hu, JL | 1 |
| Carson, MJ | 1 |
| Sutcliffe, JG | 1 |
| Ananth, US | 1 |
| Leli, U | 1 |
| Hauser, G | 1 |
7 other studies available for ketanserin and Glioma
| Article | Year |
|---|---|
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamin
Topics: Animals; Benzopyrans; Cattle; Cloning, Molecular; Glioma; HeLa Cells; Humans; Mice; Migraine Disorde | 1996 |
Effect of valproic acid on serotonin-2A receptor signaling in C6 glioma cells.
Topics: Animals; Anticonvulsants; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Glioma; Ketans | 2004 |
Dexamethasone potentiates serotonin-2 receptor-mediated intracellular Ca2+ mobilization in C6 glioma cells.
Topics: Amphetamines; Animals; Calcium; Dexamethasone; Glioma; Ketanserin; Rats; Receptors, Serotonin; Serot | 1993 |
Cyclic GMP generation mediated by 5-HT-2 receptors via nitric oxide-dependent pathway and its effect on the desensitization of 5-HT-2 receptors in C6 glioma cells.
Topics: Animals; Arginine; Calcium; Chelating Agents; Cyclic GMP; Dopamine Antagonists; Edetic Acid; Egtazic | 1995 |
Characterization of the 5-hydroxytryptamine2A receptor-activated cascade in rat C6 glioma cells.
Topics: Animals; Brain Neoplasms; Calcium; Cell Line; Dose-Response Relationship, Drug; Glioma; Ketanserin; | 1995 |
Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Colforsin; Cyclic | 2000 |
Stimulation of phosphoinositide hydrolysis by serotonin in C6 glioma cells.
Topics: Animals; Cell Line; Glioma; Hydrolysis; Inositol; Inositol Phosphates; Ketanserin; Lithium; Phosphat | 1987 |