ketanserin has been researched along with Edema-Proteinuria-Hypertension Gestosis in 25 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Determine the definitive position of ketanserin and dihydralazine for treatment of severe hypertension in pregnancy." | 9.20 | Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial. ( Bijvank, SW; Duvekot, JJ; Edens, MA; Hanff, LM; Roofthooft, DW; Steegers, EA; Visser, W; Vulto, AG, 2015) |
| "To establish the optimal dosage of ketanserin in the treatment of severe hypertension in pregnancy." | 9.10 | The optimal dosage of ketanserin for patients with severe hypertension in pregnancy. ( de Jeu, RM; Odendaal, HJ; Steyn, DW; van Geijn, HP; van Schie, DL, 2002) |
| "To compare ketanserin with hydralazine in the treatment of hypertension in late pregnancy." | 9.08 | Ketanserin and hydralazine in hypertension in pregnancy--a randomised double-blind trial. ( Howarth, G; Odendaal, HJ; Rossouw, HJ, 1995) |
| "We found an association between the addition of ketanserin to aspirin and a decrease in the number of cases of pre-eclampsia and severe hypertension, as well as improved pregnancy outcome among patients with mild to moderate midtrimester hypertension." | 9.08 | Randomised controlled trial of ketanserin and aspirin in prevention of pre-eclampsia. ( Odendaal, HJ; Steyn, DW, 1997) |
| "We investigated the effect of peripheral serotonin receptor blockade on preeclamptic hypertension in 20 postpartum patients by the use of ketanserin, a serotonin receptor antagonist." | 9.05 | Control of preeclamptic hypertension by ketanserin, a new serotonin receptor antagonist. ( Socol, ML; Vaisrub, N; Weiner, CP, 1984) |
| "After completion of this article, the reader will be able to list the various drugs and their associated side effects that are used to treat hypertensive disorders during pregnancy; to describe the various effects of serotonin on the cardiovascular system; to summarize the literature concerning the use of ketanserin during pregnancy; and to list the potential uses of ketanserin in this setting." | 8.80 | Serotonin antagonism and serotonin antagonists in pregnancy: role of ketanserin. ( Odendaal, HJ; Steyn, DW, 2000) |
| "Ketanserin is an attractive alternative in the management of severe early-onset preeclampsia." | 6.69 | Ketanserin versus dihydralazine in the management of severe early-onset preeclampsia: maternal outcome. ( Bolte, AC; Bruinse, HW; Dekker, GA; Kanhai, HH; van Eyck, J; van Geijn, HP, 1999) |
| "Ketanserin appears to be a better option than dihydralazine for treatment of severe preeclampsia since fewer maternal complications and side-effects were observed in patients receiving ketanserin." | 5.31 | Ketanserin for the treatment of preeclampsia. ( Bolte, AC; Dekker, GA; Gaffar, SF; van Eyck, J; van Geijn, HP, 2001) |
| "Ketanserin was administered intravenously as either 20 or 10 mg boluses to 16 patients with severe preeclampsia in labor." | 5.27 | Intrapartum treatment of preeclamptic hypertension by ketanserin. ( Hulme, VA; Odendaal, HJ, 1986) |
| "Oral ketanserin was used in an attempt to control gestational proteinuric hypertension and to improve perinatal outcome in 20 patients before 34 weeks." | 5.27 | [Oral ketanserin in the treatment of pre-eclampsia]. ( Hulme, VA; Odendaal, HJ, 1988) |
| "Determine the definitive position of ketanserin and dihydralazine for treatment of severe hypertension in pregnancy." | 5.20 | Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial. ( Bijvank, SW; Duvekot, JJ; Edens, MA; Hanff, LM; Roofthooft, DW; Steegers, EA; Visser, W; Vulto, AG, 2015) |
| "Ketanserin is an antihypertensive drug that is increasingly being used parenterally in the treatment of pre-eclampsia." | 5.11 | Population pharmacokinetics of ketanserin in pre-eclamptic patients and its association with antihypertensive response. ( Hanff, LM; Steegers, EA; Visser, W; Vulto, AG, 2005) |
| "To establish the optimal dosage of ketanserin in the treatment of severe hypertension in pregnancy." | 5.10 | The optimal dosage of ketanserin for patients with severe hypertension in pregnancy. ( de Jeu, RM; Odendaal, HJ; Steyn, DW; van Geijn, HP; van Schie, DL, 2002) |
| "To compare ketanserin with hydralazine in the treatment of hypertension in late pregnancy." | 5.08 | Ketanserin and hydralazine in hypertension in pregnancy--a randomised double-blind trial. ( Howarth, G; Odendaal, HJ; Rossouw, HJ, 1995) |
| "We found an association between the addition of ketanserin to aspirin and a decrease in the number of cases of pre-eclampsia and severe hypertension, as well as improved pregnancy outcome among patients with mild to moderate midtrimester hypertension." | 5.08 | Randomised controlled trial of ketanserin and aspirin in prevention of pre-eclampsia. ( Odendaal, HJ; Steyn, DW, 1997) |
| " The incidence of severe hypertension was significantly lower when nifedipine and methyldopa were administered, although preeclampsia risk was similar among antihypertensive agents." | 5.05 | Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. ( Bellos, I; Daskalakis, G; Loutradis, D; Papapanagiotou, A; Pergialiotis, V, 2020) |
| "We investigated the effect of peripheral serotonin receptor blockade on preeclamptic hypertension in 20 postpartum patients by the use of ketanserin, a serotonin receptor antagonist." | 5.05 | Control of preeclamptic hypertension by ketanserin, a new serotonin receptor antagonist. ( Socol, ML; Vaisrub, N; Weiner, CP, 1984) |
| "After completion of this article, the reader will be able to list the various drugs and their associated side effects that are used to treat hypertensive disorders during pregnancy; to describe the various effects of serotonin on the cardiovascular system; to summarize the literature concerning the use of ketanserin during pregnancy; and to list the potential uses of ketanserin in this setting." | 4.80 | Serotonin antagonism and serotonin antagonists in pregnancy: role of ketanserin. ( Odendaal, HJ; Steyn, DW, 2000) |
| "The aim of this prospective, observational study was to assess transplacental transmission of ketanserin, an antihypertensive drug used in pre-eclampsia, and to determine disposition and effects in the neonate after maternal ketanserin use." | 3.72 | Ketanserin in pre-eclamptic patients: transplacental transmission and disposition in neonates. ( Bulsink, MJ; Hanff, LM; Roofthooft, DW; Steegers, EA; Vermes, A; Visser, W; Vulto, AG, 2004) |
| "Ketanserin is an attractive alternative in the management of severe early-onset preeclampsia." | 2.69 | Ketanserin versus dihydralazine in the management of severe early-onset preeclampsia: maternal outcome. ( Bolte, AC; Bruinse, HW; Dekker, GA; Kanhai, HH; van Eyck, J; van Geijn, HP, 1999) |
| "The etiology of preeclampsia is still unknown." | 2.41 | Pharmacological treatment of severe hypertension in pregnancy and the role of serotonin(2)-receptor blockers. ( Bolte, AC; Dekker, GA; van Geijn, HP, 2001) |
| " The risk of hypotension is associated with the last dosage rate of maternal ketanserin treatment and the co-existence of maternal HELLP syndrome." | 1.38 | The effect of maternal ketanserin use on the circulation of the neonate: a prospective, observational study. ( de Vries, NK; Morssink, LP; Schaafstra, L; van Roon, EN, 2012) |
| "Pregnant women with preeclampsia have increased serotonin levels, suggesting a possible role of this amine in abnormal pregnancy." | 1.34 | Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels. ( Aranda, E; Downey, P; Giacaman, A; Mezzano, D; Romero, W; Salas, SP; Vío, CP, 2007) |
| "Ketanserin appears to be a better option than dihydralazine for treatment of severe preeclampsia since fewer maternal complications and side-effects were observed in patients receiving ketanserin." | 1.31 | Ketanserin for the treatment of preeclampsia. ( Bolte, AC; Dekker, GA; Gaffar, SF; van Eyck, J; van Geijn, HP, 2001) |
| "Ketanserin was administered intravenously as either 20 or 10 mg boluses to 16 patients with severe preeclampsia in labor." | 1.27 | Intrapartum treatment of preeclamptic hypertension by ketanserin. ( Hulme, VA; Odendaal, HJ, 1986) |
| "Oral ketanserin was used in an attempt to control gestational proteinuric hypertension and to improve perinatal outcome in 20 patients before 34 weeks." | 1.27 | [Oral ketanserin in the treatment of pre-eclampsia]. ( Hulme, VA; Odendaal, HJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhat, AD | 1 |
| Keasler, PM | 1 |
| Kolluru, L | 1 |
| Dombrowski, MM | 1 |
| Palanisamy, A | 1 |
| Singh, PM | 1 |
| Bellos, I | 1 |
| Pergialiotis, V | 1 |
| Papapanagiotou, A | 1 |
| Loutradis, D | 1 |
| Daskalakis, G | 1 |
| Bijvank, SW | 1 |
| Visser, W | 5 |
| Duvekot, JJ | 1 |
| Steegers, EA | 5 |
| Edens, MA | 1 |
| Roofthooft, DW | 2 |
| Vulto, AG | 5 |
| Hanff, LM | 5 |
| Schaafstra, L | 1 |
| van Roon, EN | 1 |
| Morssink, LP | 1 |
| de Vries, NK | 1 |
| Banga, FR | 1 |
| Bolte, AC | 4 |
| Dekker, GA | 4 |
| van Geijn, HP | 5 |
| Bulsink, MJ | 1 |
| Vermes, A | 1 |
| Gupta, S | 2 |
| Saxena, PR | 2 |
| MaassenVanDenBrink, A | 2 |
| Salas, SP | 1 |
| Giacaman, A | 1 |
| Romero, W | 1 |
| Downey, P | 1 |
| Aranda, E | 1 |
| Mezzano, D | 1 |
| Vío, CP | 1 |
| Weiner, CP | 2 |
| Socol, ML | 2 |
| Vaisrub, N | 1 |
| Gelfan, R | 1 |
| Rossouw, HJ | 1 |
| Howarth, G | 1 |
| Odendaal, HJ | 6 |
| Gajraj, NM | 1 |
| Hutter, C | 1 |
| Steyn, DW | 3 |
| van Eyck, J | 2 |
| Kanhai, HH | 1 |
| Bruinse, HW | 1 |
| Gaffar, SF | 1 |
| van Schie, DL | 1 |
| de Jeu, RM | 1 |
| Distler, A | 1 |
| Voto, LS | 1 |
| Zin, C | 1 |
| Neira, J | 1 |
| Lapidus, AM | 1 |
| Margulies, M | 1 |
| Montenegro, R | 1 |
| Knuppel, RA | 1 |
| Shah, D | 1 |
| O'Brien, WF | 1 |
| Hulme, VA | 2 |
5 reviews available for ketanserin and Edema-Proteinuria-Hypertension Gestosis
| Article | Year |
|---|---|
Treatment of acute-onset hypertension in pregnancy: A network meta-analysis of randomized controlled trials comparing anti-hypertensives and route of administration.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Humans; Hydralazine; Hypertension; Infant | 2023 |
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis.
Topics: Abruptio Placentae; Amlodipine; Antihypertensive Agents; Atenolol; Cesarean Section; Chronic Disease | 2020 |
Serotonin antagonism and serotonin antagonists in pregnancy: role of ketanserin.
Topics: Adult; Antihypertensive Agents; Clinical Trials as Topic; Female; Humans; Hypertension; Ketanserin; | 2000 |
Pharmacological treatment of severe hypertension in pregnancy and the role of serotonin(2)-receptor blockers.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diureti | 2001 |
Clinical aspects during therapy with the serotonin antagonist ketanserin.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diuretics; Double-Blind Method; Drug Combinat | 1990 |
9 trials available for ketanserin and Edema-Proteinuria-Hypertension Gestosis
| Article | Year |
|---|---|
Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial.
Topics: Adult; Antihypertensive Agents; Dihydralazine; Double-Blind Method; Female; Gestational Age; Hospita | 2015 |
Population pharmacokinetics of ketanserin in pre-eclamptic patients and its association with antihypertensive response.
Topics: Adult; Antihypertensive Agents; Female; Humans; Hypertension; Infusions, Intravenous; Ketanserin; Me | 2005 |
Control of preeclamptic hypertension by ketanserin, a new serotonin receptor antagonist.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Femal | 1984 |
Ketanserin and hydralazine in hypertension in pregnancy--a randomised double-blind trial.
Topics: Adolescent; Adult; Blood Pressure; Double-Blind Method; Female; Humans; Hydralazine; Ketanserin; Pre | 1995 |
Randomised controlled trial of ketanserin and aspirin in prevention of pre-eclampsia.
Topics: Adult; Antihypertensive Agents; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Hum | 1997 |
Ketanserin versus dihydralazine in the management of severe early-onset preeclampsia: maternal outcome.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dihydralazine; Female; HELLP Syndrome; Humans; Ketan | 1999 |
The optimal dosage of ketanserin for patients with severe hypertension in pregnancy.
Topics: Adult; Antihypertensive Agents; Cesarean Section; Double-Blind Method; Female; Humans; Hypertension; | 2002 |
Ketanserin versus alpha-methyldopa in the treatment of hypertension during pregnancy: a preliminary report.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Female; Fetus; Humans; Ketanserin; Methyldopa; Pre- | 1987 |
The effect of serotonergic blockade in postpartum preeclamptic patients.
Topics: Adult; Blood Pressure; Double-Blind Method; Female; Humans; Ketanserin; Piperidines; Pre-Eclampsia; | 1985 |
11 other studies available for ketanserin and Edema-Proteinuria-Hypertension Gestosis
| Article | Year |
|---|---|
The effect of maternal ketanserin use on the circulation of the neonate: a prospective, observational study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Heart Rate; HELLP Syndrome; Humans; Infant, | 2012 |
Ketanserin in women with chronic hypertension and underlying thrombophilia.
Topics: Adult; Antihypertensive Agents; Female; Fetal Growth Retardation; HELLP Syndrome; Humans; Hypertensi | 2004 |
Ketanserin in pre-eclamptic patients: transplacental transmission and disposition in neonates.
Topics: Adult; Antihypertensive Agents; Female; Fetal Blood; Humans; Infant, Newborn; Ketanserin; Maternal-F | 2004 |
Functional reactivity of 5-HT receptors in human umbilical cord and maternal subcutaneous fat arteries after normotensive or pre-eclamptic pregnancy.
Topics: Adult; Arteries; Blood Pressure; Data Interpretation, Statistical; Female; Fetus; Humans; Ketanserin | 2006 |
The effect of maternal ketanserin treatment on foetal 5-HT receptor function in umbilical cord artery of pre-eclamptic patients.
Topics: Adolescent; Adult; Antihypertensive Agents; Benzamides; Case-Control Studies; Dose-Response Relation | 2007 |
Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels.
Topics: 5-Hydroxytryptophan; Aldosterone; Animals; Blood Pressure; Creatinine; Disease Models, Animal; Femal | 2007 |
Intrapartum treatment of preeclamptic hypertension by ketanserin--a serotonin receptor antagonist.
Topics: Adult; Antihypertensive Agents; Delivery, Obstetric; Female; Humans; Hydralazine; Hypertension; Infa | 1984 |
Serotonin in pre-eclampsia.
Topics: Female; Humans; Ketanserin; Pre-Eclampsia; Pregnancy; Serotonin; Serotonin Antagonists | 1996 |
Ketanserin for the treatment of preeclampsia.
Topics: Antihypertensive Agents; Aspartate Aminotransferases; Delivery, Obstetric; Dihydralazine; Female; Ge | 2001 |
Intrapartum treatment of preeclamptic hypertension by ketanserin.
Topics: Blood Pressure; Female; Fetal Heart; Heart Rate; Humans; Hypertension; Ketanserin; Obstetric Labor C | 1986 |
[Oral ketanserin in the treatment of pre-eclampsia].
Topics: Administration, Oral; Adolescent; Adult; Blood Pressure; Female; Humans; Ketanserin; Pre-Eclampsia; | 1988 |