ketanserin has been researched along with Disease Models, Animal in 75 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Risperidone, 5-HT2A receptor antagonists, and D1 receptor antagonistic drugs prevented and reversed cocaine-induced hyperthermia." | 7.96 | Risperidone and 5-HT2A Receptor Antagonists Attenuate and Reverse Cocaine-Induced Hyperthermia in Rats. ( Makiguchi, A; Okada, T; Shioda, K; Suda, S, 2020) |
| "The long-term effects of the 5-HT(2A) receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801." | 7.74 | Endothelin-1-induced cerebral ischemia: effects of ketanserin and MK-801 on limb placing in rats. ( Kortenska, L; Mitreva, R; Moyanova, S, 2007) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "Ketanserin is a selective 5-hydroxytryptamine (serotonin)-2A receptor (5-HT2AR) antagonist." | 5.43 | Effects of ketanserin on experimental colitis in mice and macrophage function. ( Feng, Y; Jiang, W; Liu, F; Shao, L; Shen, J; Xiao, J; Zheng, P, 2016) |
| "Risperidone, 5-HT2A receptor antagonists, and D1 receptor antagonistic drugs prevented and reversed cocaine-induced hyperthermia." | 3.96 | Risperidone and 5-HT2A Receptor Antagonists Attenuate and Reverse Cocaine-Induced Hyperthermia in Rats. ( Makiguchi, A; Okada, T; Shioda, K; Suda, S, 2020) |
| "Control and maternally separated litters received treatment with the 5-HT(2) receptor antagonist, ketanserin, or vehicle during postnatal life and were examined for effects on adult anxiety behavior, adult stress-induced immediate early gene expression responses, and transcriptional changes within the prefrontal cortex during postnatal life and in adulthood." | 3.77 | Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress. ( Benekareddy, M; Nair, AR; Vadodaria, KC; Vaidya, VA, 2011) |
| "The acute cardiovascular and respiratory responses of the gulf toadfish, Opsanus beta, to acute hypoxia or exposure to the O(2) chemoreceptor stimulant, sodium cyanide (NaCN) were characterized and the role of serotonin type 2 (5-HT(2)) receptors in mediating these responses was investigated." | 3.76 | Cardiovascular and respiratory reflexes of the gulf toadfish (Opsanus beta) during acute hypoxia. ( Gilmour, KM; McDonald, MD; Perry, SF; Walsh, PJ, 2010) |
| " Since dietary thiamine deficiency (TD) in mice is considered as a putative model of WKS, it was used in the present study to investigate the function of serotonergic neurons in this disorder." | 3.74 | Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice. ( Arai, Y; Mitazaki, S; Murata, A; Nakagawasai, O; Niijima, F; Ohba, A; Tadano, T; Tan-No, K; Wakui, K, 2007) |
| "The long-term effects of the 5-HT(2A) receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801." | 3.74 | Endothelin-1-induced cerebral ischemia: effects of ketanserin and MK-801 on limb placing in rats. ( Kortenska, L; Mitreva, R; Moyanova, S, 2007) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| " During exposure to hypoxia (10% O2 for 2 weeks), the animals received one of the specific 5-HTT inhibitors citalopram and fluoxetine (10 mg/kg/day), the selective 5-HT1B/1D receptor antagonist GR127935 (2 and 10 mg/kg/day), or the 5-HT2A receptor antagonist ketanserin (2 mg/kg/day)." | 3.72 | Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. ( Adnot, S; Eddahibi, S; Hamon, M; Marcos, E; Nosjean, A; Pham, MH; Raffestin, B, 2003) |
| "Both normal and genetically dystonic (dt) rats show a high-frequency forepaw tremor in response to systemic administration of the serotonin (5-HT) agonist quipazine at 8 days of age." | 3.68 | Enhanced sensitivity to quipazine in the genetically dystonic rat (dt). ( Lorden, JF; Michela, VL; Stratton, SE, 1990) |
| "The relative importance of ADP, arachidonic acid metabolites and serotonin as thrombogenic factors was evaluated in rats by comparing, after oral administration, the effects of two inhibitors of ADP-induced platelet aggregation (ticlopidine and PCR 4099), three cyclo-oxygenase inhibitors (aspirin, triflusal and indobufen) and a selective serotonin 5HT2 receptor antagonist (ketanserin) on platelet aggregation, in four platelet-dependent thrombosis models and on bleeding time." | 3.67 | ADP plays a key role in thrombogenesis in rats. ( Bernat, A; Cazenave, JP; Defreyn, G; Delebassée, D; Gordon, JL; Maffrand, JP, 1988) |
| "The effects of the serotonin receptor blocker, ketanserin, were studied in a porcine Pseudomonas adult respiratory distress syndrome model." | 3.67 | Serotonin receptor blockade improves cardiac output and hypoxia in porcine ARDS. ( Kellum, JM; Kuemmerle, JF; Sielaff, TD; Sugerman, HJ; Tatum, JL, 1987) |
| "Ketanserin is a selective 5-hydroxytryptamine (serotonin)-2A receptor (5-HT2AR) antagonist." | 1.43 | Effects of ketanserin on experimental colitis in mice and macrophage function. ( Feng, Y; Jiang, W; Liu, F; Shao, L; Shen, J; Xiao, J; Zheng, P, 2016) |
| " Instead, selective serotonin 2A receptor (5HT(2A)R) antagonists ketanserin and MDL-11939 replicate the effect of SGAs, repressing the activity in WT mice at a dosage that fails to suppress the activity of Egr3(-/-) mice." | 1.38 | Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. ( Elizalde, DI; Gallitano, AL; González-Maeso, J; Ingram, WM; Janowski, SA; Kamel, CM; Kozlenkov, A; Levine, S; Lish, JR; Resnik, J; Shoker, J; Williams, AA, 2012) |
| "Fragile X syndrome is a common inherited form of mental retardation caused by the lack of fragile X mental retardation protein (FMRP) because of Fmr1 gene silencing." | 1.38 | Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome. ( Chen, GS; Li, XQ; Liu, G; Liu, SB; Ma, L; Wu, YM; Xu, ZH; Yang, Q; Zhao, MG, 2012) |
| "Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions." | 1.37 | Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions. ( Krishnamurthy, S; Saxena, B; Singh, S, 2011) |
| "Pretreatment with ketanserin significantly attenuated these effects." | 1.36 | Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. ( le Grand, SM; Srikiatkhachorn, A; Supornsilpchai, W, 2010) |
| " However, the neural mechanism by which extracellular 5-HT is elevated to a toxic level for the syndrome remains to be determined." | 1.35 | Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. ( Huang, X; Krishnamoorthy, S; Ma, Z; Tao, R; Vukovich, NP; Zhang, G, 2009) |
| " The effect of chronic ACTH treatment on 5-HT(2) receptor and 5-HT(2A)-receptor mRNA levels was not altered by the chronic administration of imipramine." | 1.35 | Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex. ( Akiyama, K; Fujitani, Y; Gomita, Y; Kanzaki, H; Kawasaki, H; Kimoto, S; Kitagawa, K; Kitamura, Y; Ouchida, M; Sendo, T; Shibata, K; Shimizu, K, 2008) |
| "Pregnant women with preeclampsia have increased serotonin levels, suggesting a possible role of this amine in abnormal pregnancy." | 1.34 | Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels. ( Aranda, E; Downey, P; Giacaman, A; Mezzano, D; Romero, W; Salas, SP; Vío, CP, 2007) |
| "Rats with congestive heart failure (CHF) develop ventricular inotropic responsiveness to serotonin (5-HT), mediated through 5-HT(2A) and 5-HT(4) receptors." | 1.34 | Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes. ( Birkeland, JA; Enger, U; Levy, FO; Lunde, PK; Qvigstad, E; Sejersted, OM; Sjaastad, I; Swift, F; Tovsrud, N, 2007) |
| "In rodent models of Parkinson's disease (PD) blockade of these receptors increases locomotion and enhances the actions of dopamine (DA) replacement therapy." | 1.33 | Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study. ( Biedka, I; Brus, R; Drosik, M; Kostrzewa, RM; Nowak, P; Szczerbak, G, 2006) |
| "Convulsions were followed by significant increase in the tail-flick latencies (TFL), at least for 30 min of the post-ictal period." | 1.31 | Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms. ( Castro-Souza, C; Coimbra, NC; Garcia-Cairasco, N; Herrero, CF; Nora, JE; Segato, EN; Tedeschi-Filho, W, 2001) |
| "Hyperalgesia due to nerve injury and hyperalgesia due to inflammation may share some common features." | 1.30 | Hyperalgesia due to nerve damage: role of nerve growth factor. ( Hu, D; Rush, AR; Theodosiou, M; Tracey, JD; Walker, SJ; Zhou, FX, 1999) |
| "The ketanserin-treated groups demonstrated improved cardiac index, decreased pulmonary artery pressures, and smaller arteriovenous oxygen content differences compared to the control group in the early postburn period." | 1.27 | The effect of ketanserin, a specific serotonin antagonist, on burn shock hemodynamic parameters in a porcine burn model. ( Holliman, CJ; Larsen, KR; Meuleman, TR; Pace, NL; Port, JD; Stanley, TH; Warden, GD, 1983) |
| "Ketanserin was infused at 300 micrograms/kg before endotoxin plus 67 micrograms/kg/h during endotoxemia." | 1.27 | Role of 5-hydroxytryptamine in endotoxin-induced respiratory failure of pigs. ( Olson, NC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (8.00) | 18.7374 |
| 1990's | 12 (16.00) | 18.2507 |
| 2000's | 30 (40.00) | 29.6817 |
| 2010's | 22 (29.33) | 24.3611 |
| 2020's | 5 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Rowley, M | 1 |
| Bristow, LJ | 1 |
| Hutson, PH | 1 |
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, Q | 1 |
| Chen, Y | 3 |
| Xing, S | 1 |
| Liao, Q | 1 |
| Xiong, B | 1 |
| Wang, Y | 1 |
| Lu, W | 1 |
| He, S | 1 |
| Feng, F | 1 |
| Liu, W | 1 |
| Sun, H | 1 |
| Yang, T | 1 |
| Wang, H | 1 |
| Li, Y | 1 |
| Zeng, Z | 1 |
| Shen, Y | 1 |
| Wan, C | 1 |
| Wu, Y | 1 |
| Dong, J | 1 |
| Chen, L | 1 |
| Wen, F | 1 |
| Okada, T | 1 |
| Shioda, K | 1 |
| Makiguchi, A | 1 |
| Suda, S | 1 |
| Mendonça-Junior, BA | 1 |
| V Fernandes, M | 1 |
| Zoccal, DB | 1 |
| Patel, R | 1 |
| Dickenson, AH | 1 |
| Delaney, C | 1 |
| Gien, J | 1 |
| Roe, G | 1 |
| Isenberg, N | 1 |
| Kailey, J | 1 |
| Abman, SH | 1 |
| Liu, C | 1 |
| Zhang, X | 1 |
| Zhou, JX | 1 |
| Wei, W | 1 |
| Liu, DH | 1 |
| Ke, P | 1 |
| Zhang, GF | 1 |
| Cai, GJ | 1 |
| Su, DF | 2 |
| Bektas, N | 1 |
| Arslan, R | 1 |
| Ozturk, Y | 1 |
| Malkova, NV | 1 |
| Gallagher, JJ | 1 |
| Yu, CZ | 1 |
| Jacobs, RE | 1 |
| Patterson, PH | 1 |
| Xiao, J | 1 |
| Shao, L | 1 |
| Shen, J | 1 |
| Jiang, W | 1 |
| Feng, Y | 1 |
| Zheng, P | 1 |
| Liu, F | 1 |
| Sasaki-Hamada, S | 1 |
| Suzuki, A | 1 |
| Ueda, Y | 1 |
| Matsumoto, K | 1 |
| Oka, JI | 1 |
| Zhang, G | 1 |
| Krishnamoorthy, S | 1 |
| Ma, Z | 1 |
| Vukovich, NP | 1 |
| Huang, X | 1 |
| Tao, R | 1 |
| Dergacheva, O | 1 |
| Kamendi, H | 1 |
| Wang, X | 2 |
| Pinol, RA | 1 |
| Frank, J | 1 |
| Gorini, C | 1 |
| Jameson, H | 1 |
| Lovett-Barr, MR | 1 |
| Mendelowitz, D | 1 |
| Huang, J | 1 |
| Cai, Q | 1 |
| Hong, Y | 2 |
| Freitas, AE | 1 |
| Budni, J | 1 |
| Lobato, KR | 1 |
| Binfaré, RW | 1 |
| Machado, DG | 1 |
| Jacinto, J | 1 |
| Veronezi, PO | 1 |
| Pizzolatti, MG | 1 |
| Rodrigues, AL | 1 |
| Supornsilpchai, W | 1 |
| le Grand, SM | 1 |
| Srikiatkhachorn, A | 1 |
| McDonald, MD | 1 |
| Gilmour, KM | 1 |
| Walsh, PJ | 1 |
| Perry, SF | 1 |
| Akiyama, T | 1 |
| Carstens, IM | 1 |
| Carstens, E | 1 |
| Benekareddy, M | 2 |
| Goodfellow, NM | 1 |
| Lambe, EK | 1 |
| Vaidya, VA | 2 |
| Saxena, B | 1 |
| Krishnamurthy, S | 1 |
| Singh, S | 1 |
| Vadodaria, KC | 1 |
| Nair, AR | 1 |
| Wang, D | 1 |
| Chen, T | 1 |
| Gao, Y | 1 |
| Quirion, R | 1 |
| Barchini, J | 1 |
| Tchachaghian, S | 1 |
| Shamaa, F | 1 |
| Jabbur, SJ | 1 |
| Meyerson, BA | 1 |
| Song, Z | 1 |
| Linderoth, B | 1 |
| Saadé, NE | 1 |
| Rani, S | 1 |
| Gupta, MC | 1 |
| Williams, AA | 1 |
| Ingram, WM | 1 |
| Levine, S | 1 |
| Resnik, J | 1 |
| Kamel, CM | 1 |
| Lish, JR | 1 |
| Elizalde, DI | 1 |
| Janowski, SA | 1 |
| Shoker, J | 1 |
| Kozlenkov, A | 1 |
| González-Maeso, J | 1 |
| Gallitano, AL | 1 |
| Xu, ZH | 1 |
| Yang, Q | 1 |
| Ma, L | 1 |
| Liu, SB | 1 |
| Chen, GS | 1 |
| Wu, YM | 1 |
| Li, XQ | 1 |
| Liu, G | 1 |
| Zhao, MG | 1 |
| Liu, Y | 1 |
| Tian, H | 1 |
| Yan, X | 1 |
| Fan, F | 1 |
| Wang, W | 1 |
| Han, J | 1 |
| Russell, A | 1 |
| Banes, A | 1 |
| Berlin, H | 1 |
| Fink, GD | 1 |
| Watts, SW | 1 |
| Nic Dhonnchadha, BA | 1 |
| Bourin, M | 1 |
| Hascoët, M | 1 |
| Klisch, J | 1 |
| Bode-Greuel, KM | 1 |
| Horvath, E | 1 |
| Klisch, C | 1 |
| Els, T | 1 |
| Marcos, E | 1 |
| Adnot, S | 1 |
| Pham, MH | 1 |
| Nosjean, A | 1 |
| Raffestin, B | 1 |
| Hamon, M | 1 |
| Eddahibi, S | 1 |
| Deuchar, GA | 1 |
| Hicks, MN | 1 |
| MacLean, MR | 1 |
| Okamoto, K | 3 |
| Imbe, H | 3 |
| Tashiro, A | 1 |
| Kimura, A | 3 |
| Donishi, T | 3 |
| Tamai, Y | 3 |
| Senba, E | 3 |
| Nitanda, A | 1 |
| Yasunami, N | 1 |
| Tokumo, K | 1 |
| Fujii, H | 1 |
| Hirai, T | 1 |
| Nishio, H | 1 |
| Chang, CP | 1 |
| Chen, SH | 1 |
| Lin, MT | 1 |
| Papadimas, GK | 2 |
| Tzirogiannis, KN | 2 |
| Panoutsopoulos, GI | 2 |
| Demonakou, MD | 2 |
| Skaltsas, SD | 2 |
| Hereti, RI | 2 |
| Papadopoulou-Daifoti, Z | 1 |
| Mykoniatis, MG | 2 |
| Zhao, A | 1 |
| Urban, JF | 1 |
| Morimoto, M | 1 |
| Elfrey, JE | 1 |
| Madden, KB | 1 |
| Finkelman, FD | 1 |
| Shea-Donohue, T | 1 |
| Nishie, Y | 1 |
| Matsushita, H | 1 |
| Nowak, P | 1 |
| Szczerbak, G | 1 |
| Biedka, I | 1 |
| Drosik, M | 1 |
| Kostrzewa, RM | 1 |
| Brus, R | 1 |
| Nakagawasai, O | 1 |
| Murata, A | 1 |
| Arai, Y | 1 |
| Ohba, A | 1 |
| Wakui, K | 1 |
| Mitazaki, S | 1 |
| Niijima, F | 1 |
| Tan-No, K | 1 |
| Tadano, T | 1 |
| Toppin, VA | 1 |
| Harris, MB | 1 |
| Kober, AM | 1 |
| Leiter, JC | 2 |
| St-John, WM | 2 |
| Manta, GA | 1 |
| Kourentzi, KT | 1 |
| Alexandropoulou, KN | 1 |
| Shen, FM | 1 |
| Wang, J | 1 |
| Ni, CR | 1 |
| Yu, JG | 1 |
| Wang, WZ | 1 |
| Salas, SP | 1 |
| Giacaman, A | 1 |
| Romero, W | 1 |
| Downey, P | 1 |
| Aranda, E | 1 |
| Mezzano, D | 1 |
| Vío, CP | 1 |
| Moyanova, S | 1 |
| Kortenska, L | 1 |
| Mitreva, R | 1 |
| Birkeland, JA | 1 |
| Swift, F | 1 |
| Tovsrud, N | 1 |
| Enger, U | 1 |
| Lunde, PK | 1 |
| Qvigstad, E | 1 |
| Levy, FO | 1 |
| Sejersted, OM | 1 |
| Sjaastad, I | 1 |
| Kitamura, Y | 1 |
| Shibata, K | 1 |
| Akiyama, K | 1 |
| Kimoto, S | 1 |
| Fujitani, Y | 1 |
| Kitagawa, K | 1 |
| Kanzaki, H | 1 |
| Ouchida, M | 1 |
| Shimizu, K | 1 |
| Kawasaki, H | 1 |
| Sendo, T | 1 |
| Gomita, Y | 1 |
| Xie, H | 1 |
| Dong, ZQ | 1 |
| Ma, F | 1 |
| Bauer, WR | 1 |
| Wu, GC | 1 |
| Holliman, CJ | 1 |
| Meuleman, TR | 1 |
| Larsen, KR | 1 |
| Port, JD | 1 |
| Stanley, TH | 1 |
| Pace, NL | 1 |
| Warden, GD | 1 |
| Grover, GJ | 1 |
| Sargent, CA | 1 |
| Dzwonczyk, S | 1 |
| Normandin, DE | 1 |
| Antonaccio, MJ | 1 |
| Kesecioglu, J | 1 |
| Ince, C | 1 |
| Pompe, JC | 1 |
| Gültuna, I | 1 |
| Erdmann, W | 1 |
| Bruining, HA | 1 |
| Hirata, Y | 1 |
| Umemura, K | 1 |
| Uematsu, T | 1 |
| Nakashima, M | 1 |
| Prinssen, EP | 1 |
| Ellenbroek, BA | 1 |
| Cools, AR | 1 |
| Naess, F | 1 |
| Waage, A | 1 |
| Roeise, O | 1 |
| Stadaas, JO | 1 |
| Aasen, AO | 1 |
| Takahashi, T | 1 |
| Fukai, T | 1 |
| Hata, H | 1 |
| Kasuya, H | 1 |
| Kuga, T | 1 |
| Egashira, K | 2 |
| Takeshita, A | 1 |
| Herbert, JM | 1 |
| Bernat, A | 2 |
| Barthelemy, G | 1 |
| Dol, F | 1 |
| Rinaldi, M | 1 |
| Grignaschi, G | 1 |
| Mantelli, B | 1 |
| Samanin, R | 1 |
| Beaughard, M | 1 |
| Brasset, M | 1 |
| John, G | 1 |
| Massingham, R | 1 |
| Theodosiou, M | 1 |
| Rush, AR | 1 |
| Zhou, FX | 1 |
| Hu, D | 1 |
| Walker, SJ | 1 |
| Tracey, JD | 1 |
| Coimbra, NC | 1 |
| Castro-Souza, C | 1 |
| Segato, EN | 1 |
| Nora, JE | 1 |
| Herrero, CF | 1 |
| Tedeschi-Filho, W | 1 |
| Garcia-Cairasco, N | 1 |
| Wohlsen, A | 1 |
| Uhlig, S | 1 |
| Martin, C | 1 |
| van Zwieten, PA | 1 |
| Blauw, GJ | 1 |
| van Brummelen, P | 1 |
| Michela, VL | 1 |
| Stratton, SE | 1 |
| Lorden, JF | 1 |
| Hladovec, J | 1 |
| Yamamoto, Y | 1 |
| Tomoike, H | 1 |
| Nakamura, M | 1 |
| Maffrand, JP | 1 |
| Delebassée, D | 1 |
| Defreyn, G | 1 |
| Cazenave, JP | 1 |
| Gordon, JL | 1 |
| Olson, NC | 1 |
| Sielaff, TD | 1 |
| Kellum, JM | 1 |
| Sugerman, HJ | 1 |
| Kuemmerle, JF | 1 |
| Tatum, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Proposal To Develop A Rapid And Cost-Effective Diagnostic Test For Schizophrenia[NCT03781115] | Phase 1 | 24 participants (Anticipated) | Interventional | 2017-11-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketanserin and Disease Models, Animal
| Article | Year |
|---|---|
Current and novel approaches to the drug treatment of schizophrenia.
Topics: Animals; Antipsychotic Agents; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; E | 2001 |
Serotonergic receptors and drugs in hypertension.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Anim | 1992 |
73 other studies available for ketanserin and Disease Models, Animal
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.
Topics: Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cell Survival; Cholinesterase | 2021 |
Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice.
Topics: Airway Remodeling; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Injections | 2020 |
Risperidone and 5-HT2A Receptor Antagonists Attenuate and Reverse Cocaine-Induced Hyperthermia in Rats.
Topics: Animals; Benzazepines; Cocaine; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibi | 2020 |
Acute intermittent hypoxia evokes ventilatory long-term facilitation and active expiration in unanesthetized rats.
Topics: Animals; Disease Models, Animal; Hypoxia; Ketanserin; Male; Pulmonary Ventilation; Rats; Rats, Sprag | 2021 |
Modality selective roles of pro-nociceptive spinal 5-HT
Topics: Animals; Disease Models, Animal; Ketanserin; Male; Membrane Potentials; Neural Pathways; Neuralgia; | 2018 |
Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn.
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmona | 2013 |
The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Disease Models, Animal; Electrophoretic Mobilit | 2013 |
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diabetic Neuropathies; Disease Models, Animal; Dose-Respons | 2014 |
Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia.
Topics: Amphetamines; Animals; Behavior, Animal; Brain Mapping; Brain-Derived Neurotrophic Factor; Contrast | 2014 |
Effects of ketanserin on experimental colitis in mice and macrophage function.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Ketanserin; Macrophages; Male; Mi | 2016 |
Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dopamine Agents; Drugs, Chinese Herbal; Fenc | 2017 |
Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Cyproheptadine; D | 2009 |
5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Heart; Hypoxia, Brain; Ketanser | 2009 |
Treatment with ketanserin produces opioid-mediated hypoalgesia in the late phase of carrageenan-induced inflammatory hyperalgesia in rats.
Topics: Analgesia; Animals; Carrageenan; Disease Models, Animal; Hot Temperature; Hyperalgesia; Inflammation | 2009 |
Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antidepressive Agents; Biogenic Monoami | 2010 |
Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cerebral Cortex; Cerebrovascular Circulation; Dise | 2010 |
Cardiovascular and respiratory reflexes of the gulf toadfish (Opsanus beta) during acute hypoxia.
Topics: Analysis of Variance; Animals; Batrachoidiformes; Bradycardia; Cardiovascular System; Disease Models | 2010 |
Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch.
Topics: Animals; Antibodies; Behavior, Animal; Calcium; Capsaicin; Disease Models, Animal; Ganglia, Spinal; | 2010 |
Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability.
Topics: AIDS-Related Complex; Amphetamines; Analysis of Variance; Animals; Animals, Newborn; Behavior, Anima | 2010 |
Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.
Topics: Animals; Antipsychotic Agents; Capillary Permeability; Dinoprostone; Disease Models, Animal; Dopamin | 2011 |
Postnatal serotonin type 2 receptor blockade prevents the emergence of anxiety behavior, dysregulated stress-induced immediate early gene responses, and specific transcriptional changes that arise following early life stress.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Apoptosis Regulatory Proteins | 2011 |
Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Disease Models, Animal; Ganglia, Spinal; Hype | 2012 |
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen; | 2012 |
Evaluation and comparison of antinociceptive activity of aspartame with sucrose.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Aspartame; Disease Models, Animal; Ketanser | 2012 |
Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.
Topics: Animals; Clozapine; Disease Models, Animal; Early Growth Response Protein 3; Humans; Hypnotics and S | 2012 |
Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome.
Topics: Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Fragile X Mental Retardation Pr | 2012 |
Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Familial Primary Pu | 2013 |
5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Disease Models, Animal; Endothelium, Vascular; Hu | 2002 |
Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety.
Topics: Amphetamines; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dose-Response Relations | 2003 |
Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female | 2003 |
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.
Topics: Analysis of Variance; Animals; Carrier Proteins; Chronic Disease; Citalopram; Disease Models, Animal | 2003 |
The role of 5-hydroxytryptamine in the control of pulmonary vascular tone in a rabbit model of pulmonary hypertension secondary to left ventricular dysfunction.
Topics: Animals; Aorta; Blood Pressure; Cardiac Output; Disease Models, Animal; Heart Rate; Hypertension, Pu | 2005 |
The role of peripheral 5HT2A and 5HT1A receptors on the orofacial formalin test in rats with persistent temporomandibular joint inflammation.
Topics: Animals; Arthralgia; Arthritis; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pai | 2005 |
Contribution of the peripheral 5-HT 2A receptor to mechanical hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Binding Sites; Binding, Competitive; Denervation; Disease Models, Animal; Drug Interactions | 2005 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Effect of serotonin receptor 2 blockage on liver regeneration after partial hepatectomy in the rat liver.
Topics: Animals; Cell Proliferation; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Hepatect | 2006 |
Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility.
Topics: Animals; Disease Models, Animal; Female; Gene Expression; Ketanserin; Mice; Mice, Inbred BALB C; Mus | 2006 |
Contribution of peripheral 5-HT2A or 5-HT3 receptors to Fos expression in the trigeminal spinal nucleus produced by acute injury to the masseter muscle during persistent temporomandibular joint inflammation in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Freund's Adjuvant; | 2006 |
Effect of ketanserin and amphetamine on nigrostriatal neurotransmission and reactive oxygen species in Parkinsonian rats. In vivo microdialysis study.
Topics: Amphetamine; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Ketanserin; Male; Microdia | 2006 |
Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice.
Topics: Amphetamines; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleran | 2007 |
Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Decerebrate State; Disease Models, Animal; Dose-Res | 2007 |
Effect of 5-HT(2) receptor blockade on cadmium-induced acute toxicity.
Topics: Animals; Apoptosis; Cadmium; Disease Models, Animal; In Situ Nick-End Labeling; Ketanserin; Liver Fa | 2007 |
Activation of central 5HT2A receptors reduces the craniofacial nociception of rats.
Topics: Action Potentials; Amphetamines; Animals; Behavior, Animal; Disease Models, Animal; Drug Interaction | 2007 |
Ketanserin-induced baroreflex enhancement in spontaneously hypertensive rats depends on central 5-HT(2A) receptors.
Topics: Animals; Antibodies, Monoclonal; Antihypertensive Agents; Baroreflex; Blood Pressure; Brain; Disease | 2007 |
Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels.
Topics: 5-Hydroxytryptophan; Aldosterone; Animals; Blood Pressure; Creatinine; Disease Models, Animal; Femal | 2007 |
Endothelin-1-induced cerebral ischemia: effects of ketanserin and MK-801 on limb placing in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Dizocilpine | 2007 |
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Calcium Channels, L-Type; Calcium Signaling; C | 2007 |
Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Am | 2008 |
Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex.
Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Binding Sites; | 2008 |
Involvement of serotonin 2A receptors in the analgesic effect of tramadol in mono-arthritic rats.
Topics: Analgesics, Opioid; Animals; Arthralgia; Arthritis; Brain; Disease Models, Animal; Dose-Response Rel | 2008 |
The effect of ketanserin, a specific serotonin antagonist, on burn shock hemodynamic parameters in a porcine burn model.
Topics: Animals; Blood Pressure; Body Temperature; Burns; Disease Models, Animal; Heart Rate; Hemodynamics; | 1983 |
Protective effect of serotonin (5-HT2) receptor antagonists in ischemic rat hearts.
Topics: Animals; Cinanserin; Disease Models, Animal; Ergolines; Heart; Hemodynamics; Ketanserin; L-Lactate D | 1993 |
Effect of ketanserine on oxygenation and ventilation inhomogeneity in pigs with ARDS.
Topics: Animals; Bronchoconstriction; Disease Models, Animal; Hemodynamics; Ketanserin; Oxygen Consumption; | 1994 |
An experimental myocardial infarction model in the rat and its properties.
Topics: Animals; Biphenyl Compounds; Clopidogrel; Coronary Vessels; Disease Models, Animal; Electrocardiogra | 1995 |
Combined antagonism of adrenoceptors and dopamine and 5-HT receptors underlies the atypical profile of clozapine.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Animals; Benzazepines; Clozapine; Dis | 1994 |
Effects of a combined drug regimen on tumour necrosis factor and plasma kallikrein activity in experimental endotoxaemia.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Escherichia coli Infections; Hemodynamic | 1994 |
Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs.
Topics: Animals; Calcium Channel Blockers; Coronary Vasospasm; Disease Models, Animal; Histamine; Infusions, | 1993 |
Antithrombotic activity of SR 46349, a novel, potent and selective 5-HT2 receptor antagonist.
Topics: Animals; Bleeding Time; Coronary Circulation; Depression, Chemical; Disease Models, Animal; Dogs; Fi | 1993 |
The hypophagic effect of restraint stress in rats can be mediated by 5-HT2 receptors in the paraventricular nucleus of the hypothalamus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amidines; Animals; Anorexia; Anorexia Nervosa; Disease Model | 1993 |
Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury.
Topics: Animals; Aspirin; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Disea | 1995 |
Hyperalgesia due to nerve damage: role of nerve growth factor.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Humans; Hyperalgesia; Immune Ser | 1999 |
Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms.
Topics: Analgesia; Animals; Atropine; Convulsants; Disease Models, Animal; Injections, Intraperitoneal; Keta | 2001 |
Immediate allergic response in small airways.
Topics: Allergens; Animals; Asthma; Bronchial Diseases; Constriction, Pathologic; Disease Models, Animal; Dr | 2001 |
Enhanced sensitivity to quipazine in the genetically dystonic rat (dt).
Topics: Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Ketanserin; Phen | 1990 |
A sensitive model of venous thrombosis in rats.
Topics: Animals; Anticoagulants; Aspirin; Dipyridamole; Disease Models, Animal; Female; Heparin; Ketanserin; | 1986 |
Attenuation of endothelium-related relaxation and enhanced responsiveness of vascular smooth muscle to histamine in spastic coronary arterial segments from miniature pigs.
Topics: Animals; Calcimycin; Coronary Vasospasm; Dinoprost; Disease Models, Animal; Endothelium, Vascular; H | 1987 |
ADP plays a key role in thrombogenesis in rats.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Cyclooxygenase Inhibitors; Disease Models, Animal; Fema | 1988 |
Role of 5-hydroxytryptamine in endotoxin-induced respiratory failure of pigs.
Topics: Acute Disease; Angiotensin II; Animals; Bronchi; Constriction, Pathologic; Dinoprost; Disease Models | 1987 |
Serotonin receptor blockade improves cardiac output and hypoxia in porcine ARDS.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Histamine Antagonists; Hypoxia; Ket | 1987 |