ketanserin has been researched along with Depressive Disorder in 18 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Triiodothyronine (T3) has been shown to accelerate and potentiate the clinical response to tricyclic antidepressant (TCA) treatment in depressive disorders." | 3.71 | Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain. ( Jeanningros, R; Mazzola-Pomietto, P; Moreau, X, 2001) |
| "However, the patients with Alzheimer's disease had significantly lower binding than the normal subjects in several brain regions, including the anterior cingulate, prefrontal cortex, and sensorimotor cortex." | 1.30 | PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders. ( Ben-Eliezer, D; Cantwell, MN; DeKosky, ST; Greer, PJ; Houck, PR; Lopresti, B; Mathis, CA; Meltzer, CC; Mulsant, BH; Price, JC; Reynolds, CF, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 10 (55.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosel, P | 1 |
| Arranz, B | 2 |
| Urretavizcaya, M | 1 |
| Oros, M | 1 |
| San, L | 1 |
| Navarro, MA | 1 |
| Sheline, YI | 1 |
| Mintun, MA | 1 |
| Barch, DM | 1 |
| Wilkins, C | 1 |
| Snyder, AZ | 1 |
| Moerlein, SM | 1 |
| Crow, TJ | 1 |
| Cross, AJ | 1 |
| Cooper, SJ | 1 |
| Deakin, JF | 1 |
| Ferrier, IN | 2 |
| Johnson, JA | 1 |
| Joseph, MH | 1 |
| Owen, F | 1 |
| Poulter, M | 1 |
| Lofthouse, R | 1 |
| Eriksson, A | 1 |
| Mellerup, E | 1 |
| Plenge, P | 1 |
| Marcusson, J | 1 |
| Hrdina, PD | 1 |
| Demeter, E | 1 |
| Vu, TB | 1 |
| Sótónyi, P | 1 |
| Palkovits, M | 1 |
| Biver, F | 1 |
| Wikler, D | 1 |
| Lotstra, F | 1 |
| Damhaut, P | 1 |
| Goldman, S | 1 |
| Mendlewicz, J | 1 |
| Meltzer, CC | 1 |
| Price, JC | 1 |
| Mathis, CA | 1 |
| Greer, PJ | 1 |
| Cantwell, MN | 1 |
| Houck, PR | 1 |
| Mulsant, BH | 1 |
| Ben-Eliezer, D | 1 |
| Lopresti, B | 1 |
| DeKosky, ST | 1 |
| Reynolds, CF | 1 |
| Moreau, X | 1 |
| Jeanningros, R | 1 |
| Mazzola-Pomietto, P | 1 |
| Larisch, R | 1 |
| Klimke, A | 1 |
| Mayoral, F | 1 |
| Hamacher, K | 1 |
| Herzog, HR | 1 |
| Vosberg, H | 1 |
| Tosch, M | 1 |
| Gaebel, W | 1 |
| Rivas, F | 1 |
| Coenen, HH | 1 |
| Müller-Gärtner, HW | 1 |
| D'haenen, H | 1 |
| Bossuyt, A | 1 |
| Mertens, J | 1 |
| Bossuyt-Piron, C | 1 |
| Gijsemans, M | 1 |
| Kaufman, L | 1 |
| Mikuni, M | 1 |
| Kusumi, I | 1 |
| Kagaya, A | 1 |
| Kuroda, Y | 1 |
| Mori, H | 1 |
| Takahashi, K | 1 |
| Yates, M | 2 |
| Morris, C | 1 |
| Cheng, AV | 1 |
| Ferrier, N | 1 |
| Biegon, A | 2 |
| Grinspoon, A | 1 |
| Blumenfeld, B | 1 |
| Bleich, A | 1 |
| Apter, A | 1 |
| Mester, R | 1 |
| Leake, A | 1 |
| Candy, JM | 1 |
| Fairbairn, AF | 1 |
| McKeith, IG | 1 |
| Essar, N | 1 |
| Israeli, M | 1 |
| Elizur, A | 1 |
| Bruch, S | 1 |
| Bar-Nathan, AA | 1 |
| Baudouin-Legros, M | 1 |
| Le Quan-Bui, KH | 1 |
| Guicheney, P | 1 |
| Kamal, LA | 1 |
| Meyer, P | 1 |
| Wamsley, JK | 1 |
| Byerley, WF | 1 |
| McCabe, RT | 1 |
| McConnell, EJ | 1 |
| Dawson, TM | 1 |
| Grosser, BI | 1 |
| Cheetham, SC | 1 |
| Crompton, MR | 1 |
| Katona, CL | 1 |
| Horton, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| New IDEAS: Imaging Dementia-Evidence for Amyloid Scanning Study - A Study to Improve Precision in Amyloid PET Coverage and Patient Care[NCT04426539] | 7,000 participants (Anticipated) | Observational [Patient Registry] | 2020-12-17 | Recruiting | |||
| Kinetic Studies in Whole Body and Brain of [11C]DASB PET Imaging of Serotonin Transporters[NCT00059046] | 20 participants | Observational | 2003-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for ketanserin and Depressive Disorder
| Article | Year |
|---|---|
Altered 5-HT2A and 5-HT4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims.
Topics: Adolescent; Adult; Aged; Binding Sites; Brain; Case-Control Studies; Cyclic AMP; Depressive Disorder | 2004 |
Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography.
Topics: Aged; Aged, 80 and over; Brain Mapping; Case-Control Studies; Depressive Disorder; Female; Fluorine | 2004 |
Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides.
Topics: Aged; Aging; Alzheimer Disease; Binding, Competitive; Biogenic Amines; Brain; Choline O-Acetyltransf | 1984 |
Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Age Factors; Brain; Depressive Disorder; | 1994 |
5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala.
Topics: Adult; Aged; Amygdala; Binding, Competitive; Cerebral Cortex; Depressive Disorder; Female; Humans; I | 1993 |
Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex.
Topics: Brain Diseases; Depressive Disorder; Female; Humans; Ketanserin; Male; Middle Aged; Receptors, Serot | 1997 |
PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders.
Topics: Age Factors; Aged; Alzheimer Disease; Brain; Cerebral Cortex; Depressive Disorder; Female; Fluorine | 1999 |
Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brai | 2001 |
Disturbance of serotonin 5HT2 receptors in remitted patients suffering from hereditary depressive disorder.
Topics: Adult; Aged; Aging; Brain; Cerebral Cortex; Depressive Disorder; Female; Fluorine Radioisotopes; Hum | 2001 |
SPECT imaging of serotonin2 receptors in depression.
Topics: Adolescent; Adult; Aged; Brain; Brain Mapping; Cerebral Cortex; Depressive Disorder; Dominance, Cere | 1992 |
Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients.
Topics: Adult; Aged; Blood Platelets; Depressive Disorder; Humans; Hydrolysis; In Vitro Techniques; Inosine | 1991 |
Laterality and 5HT2 receptors in human brain.
Topics: Aged; Depressive Disorder; Female; Frontal Lobe; Functional Laterality; Humans; Ketanserin; Male; Mi | 1991 |
Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men.
Topics: Adolescent; Adult; Blood Platelets; Cell Membrane; Depressive Disorder; Humans; Ketanserin; Male; Re | 1990 |
5HT2 receptor changes in major depression.
Topics: Aged; Antidepressive Agents; Autoradiography; Bipolar Disorder; Cohort Studies; Depressive Disorder; | 1990 |
Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder.
Topics: Adult; Aged; Biomarkers; Blood Platelets; Cell Membrane; Depressive Disorder; Female; Humans; Ketans | 1990 |
Platelet serotonin in essential hypertension and in mental depression.
Topics: Adult; Antidepressive Agents; Blood Platelets; Depressive Disorder; Female; Humans; Hypertension; Ke | 1985 |
Receptor alterations associated with serotonergic agents: an autoradiographic analysis.
Topics: Animals; Antidepressive Agents; Autoradiography; Brain; Carrier Proteins; Depressive Disorder; Dose- | 1987 |
Brain 5-HT2 receptor binding sites in depressed suicide victims.
Topics: Adolescent; Adult; Brain; Cell Membrane; Depressive Disorder; Female; Humans; Ketanserin; Male; Midd | 1988 |