Page last updated: 2024-10-29

ketanserin and Depressive Disorder, Major

ketanserin has been researched along with Depressive Disorder, Major in 7 studies

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
"In suicide subjects, lifetime aggression scores correlated positively with [(3)H] ketanserin binding in all prefrontal Brodmann areas examined, after adjusting for age and sex."3.73Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. ( Arango, V; Ellis, SP; Kassir, SA; Mann, JJ; Oquendo, MA; Russo, SA; Underwood, MD, 2006)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Muguruza, C1
Miranda-Azpiazu, P1
Díez-Alarcia, R1
Morentin, B1
González-Maeso, J1
Callado, LF1
Meana, JJ1
Underwood, MD2
Kassir, SA2
Bakalian, MJ1
Galfalvy, H1
Mann, JJ2
Arango, V2
Larisch, R1
Klimke, A1
Hamacher, K1
Henning, U1
Estalji, S1
Hohlfeld, T1
Vosberg, H1
Tosch, M1
Gaebel, W1
Coenen, HH1
Müller-Gärtner, HW1
Mintun, MA1
Sheline, YI1
Moerlein, SM1
Vlassenko, AG1
Huang, Y1
Snyder, AZ1
Oquendo, MA1
Russo, SA1
Ellis, SP1
Frokjaer, VG1
Mortensen, EL1
Nielsen, FA1
Haugbol, S1
Pinborg, LH1
Adams, KH1
Svarer, C1
Hasselbalch, SG1
Holm, S1
Paulson, OB1
Knudsen, GM1
Mentré, F1
Golmard, JL1
Launay, JM1
Aubin-Brunet, V1
Bouhassira, M1
Jouvent, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513]Phase 235 participants (Anticipated)Interventional2024-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for ketanserin and Depressive Disorder, Major

ArticleYear
Influence of synaptic serotonin level on [18F]altanserin binding to 5HT2 receptors in man.
    Behavioural brain research, 2003, Feb-17, Volume: 139, Issue:1-2

    Topics: Adult; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Depressive Disorder, Major; Drug Inter

2003

Other Studies

6 other studies available for ketanserin and Depressive Disorder, Major

ArticleYear
Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.
    Neuropharmacology, 2014, Volume: 86

    Topics: Amino Acids; Animals; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Down-Regulation

2014
Neuron density and serotonin receptor binding in prefrontal cortex in suicide.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Autoradiography; Case-Control Studi

2012
Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography.
    Biological psychiatry, 2004, Feb-01, Volume: 55, Issue:3

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Depressive Disorder, Major; Femal

2004
Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide.
    Biological psychiatry, 2006, Feb-01, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aggression; Depressive Disorder, Major; Female; Humans;

2006
Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder.
    Biological psychiatry, 2008, Mar-15, Volume: 63, Issue:6

    Topics: Adolescent; Adult; Aged; Biomarkers; Character; Depressive Disorder, Major; Dominance, Cerebral; Fem

2008
Relationships between low red blood cell count and clinical response to fluoxetine in depressed elderly patients.
    Psychiatry research, 1998, Dec-14, Volume: 81, Issue:3

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Blood Platelets; Carrier Proteins

1998