ketanserin has been researched along with Depression, Involutional in 7 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In suicide subjects, lifetime aggression scores correlated positively with [(3)H] ketanserin binding in all prefrontal Brodmann areas examined, after adjusting for age and sex." | 3.73 | Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. ( Arango, V; Ellis, SP; Kassir, SA; Mann, JJ; Oquendo, MA; Russo, SA; Underwood, MD, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muguruza, C | 1 |
| Miranda-Azpiazu, P | 1 |
| Díez-Alarcia, R | 1 |
| Morentin, B | 1 |
| González-Maeso, J | 1 |
| Callado, LF | 1 |
| Meana, JJ | 1 |
| Underwood, MD | 2 |
| Kassir, SA | 2 |
| Bakalian, MJ | 1 |
| Galfalvy, H | 1 |
| Mann, JJ | 2 |
| Arango, V | 2 |
| Larisch, R | 1 |
| Klimke, A | 1 |
| Hamacher, K | 1 |
| Henning, U | 1 |
| Estalji, S | 1 |
| Hohlfeld, T | 1 |
| Vosberg, H | 1 |
| Tosch, M | 1 |
| Gaebel, W | 1 |
| Coenen, HH | 1 |
| Müller-Gärtner, HW | 1 |
| Mintun, MA | 1 |
| Sheline, YI | 1 |
| Moerlein, SM | 1 |
| Vlassenko, AG | 1 |
| Huang, Y | 1 |
| Snyder, AZ | 1 |
| Oquendo, MA | 1 |
| Russo, SA | 1 |
| Ellis, SP | 1 |
| Frokjaer, VG | 1 |
| Mortensen, EL | 1 |
| Nielsen, FA | 1 |
| Haugbol, S | 1 |
| Pinborg, LH | 1 |
| Adams, KH | 1 |
| Svarer, C | 1 |
| Hasselbalch, SG | 1 |
| Holm, S | 1 |
| Paulson, OB | 1 |
| Knudsen, GM | 1 |
| Mentré, F | 1 |
| Golmard, JL | 1 |
| Launay, JM | 1 |
| Aubin-Brunet, V | 1 |
| Bouhassira, M | 1 |
| Jouvent, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ketanserin and Depression, Involutional
| Article | Year |
|---|---|
Influence of synaptic serotonin level on [18F]altanserin binding to 5HT2 receptors in man.
Topics: Adult; Antidepressive Agents, Tricyclic; Brain; Clomipramine; Depressive Disorder, Major; Drug Inter | 2003 |
6 other studies available for ketanserin and Depression, Involutional
| Article | Year |
|---|---|
Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.
Topics: Amino Acids; Animals; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Down-Regulation | 2014 |
Neuron density and serotonin receptor binding in prefrontal cortex in suicide.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Autoradiography; Case-Control Studi | 2012 |
Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Depressive Disorder, Major; Femal | 2004 |
Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aggression; Depressive Disorder, Major; Female; Humans; | 2006 |
Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder.
Topics: Adolescent; Adult; Aged; Biomarkers; Character; Depressive Disorder, Major; Dominance, Cerebral; Fem | 2008 |
Relationships between low red blood cell count and clinical response to fluoxetine in depressed elderly patients.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Blood Platelets; Carrier Proteins | 1998 |