ketanserin has been researched along with Chronic Disease in 17 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers." | 9.12 | Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. ( Cauwenbergh, G; Kharfi, M; Paquet, P; Piérard, GE; Quatresooz, P; Vroome, V, 2006) |
| "Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers." | 5.12 | Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. ( Cauwenbergh, G; Kharfi, M; Paquet, P; Piérard, GE; Quatresooz, P; Vroome, V, 2006) |
| " The incidence of severe hypertension was significantly lower when nifedipine (odds ratio, 0." | 5.05 | Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. ( Bellos, I; Daskalakis, G; Loutradis, D; Papapanagiotou, A; Pergialiotis, V, 2020) |
| " During exposure to hypoxia (10% O2 for 2 weeks), the animals received one of the specific 5-HTT inhibitors citalopram and fluoxetine (10 mg/kg/day), the selective 5-HT1B/1D receptor antagonist GR127935 (2 and 10 mg/kg/day), or the 5-HT2A receptor antagonist ketanserin (2 mg/kg/day)." | 3.72 | Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. ( Adnot, S; Eddahibi, S; Hamon, M; Marcos, E; Nosjean, A; Pham, MH; Raffestin, B, 2003) |
| " In contrast, chronic administration of imipramine, mianserin, and tranylcypromine, treatments that decreased ligand binding, did not decrease levels of 5-HT2 receptor mRNA." | 1.29 | Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex. ( Butler, MO; Duman, RS; Morinobu, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bellos, I | 1 |
| Pergialiotis, V | 1 |
| Papapanagiotou, A | 1 |
| Loutradis, D | 1 |
| Daskalakis, G | 1 |
| Cao, Y | 1 |
| Liu, C | 1 |
| Ling, L | 2 |
| Marcos, E | 1 |
| Adnot, S | 1 |
| Pham, MH | 1 |
| Nosjean, A | 1 |
| Raffestin, B | 1 |
| Hamon, M | 1 |
| Eddahibi, S | 1 |
| McGuire, M | 1 |
| Zhang, Y | 1 |
| White, DP | 1 |
| Golder, FJ | 1 |
| Mitchell, GS | 1 |
| Quatresooz, P | 1 |
| Kharfi, M | 1 |
| Paquet, P | 1 |
| Vroome, V | 1 |
| Cauwenbergh, G | 1 |
| Piérard, GE | 1 |
| Hedner, T | 1 |
| Persson, B | 1 |
| Berglund, G | 1 |
| Cazzola, M | 1 |
| Matera, MG | 1 |
| D'Amato, G | 1 |
| Rossi, F | 1 |
| Butler, MO | 1 |
| Morinobu, S | 1 |
| Duman, RS | 1 |
| Hemmeter, U | 1 |
| Kocher, R | 1 |
| Ladewig, D | 1 |
| Hatzinger, M | 1 |
| Seifritz, E | 1 |
| Lauer, CJ | 1 |
| Holsboer-Trachsler, E | 1 |
| Buus, NH | 1 |
| Terp, K | 1 |
| Baandrup, U | 1 |
| Mulvany, MJ | 1 |
| Nyborg, NC | 1 |
| Efimov, VV | 1 |
| Blazhko, VI | 1 |
| Voeĭkdova, LS | 1 |
| Liashenko, MM | 1 |
| Bondar', TN | 1 |
| Rooman, RP | 1 |
| Janssen, H | 1 |
| Mayeda, AR | 1 |
| Simon, JR | 1 |
| Hingtgen, JN | 1 |
| Hofstetter, JR | 1 |
| Aprison, MH | 1 |
| Rustin, MH | 1 |
| Bunker, CB | 1 |
| Dowd, PM | 1 |
| De Lorenzo, A | 1 |
| Ceccanti, M | 1 |
| Assogna, G | 1 |
| Romeo, M | 1 |
| Cavalieri, G | 1 |
| Attilia, ML | 1 |
| Mita, T | 1 |
| Hanada, S | 1 |
| Nishino, N | 1 |
| Kuno, T | 1 |
| Nakai, H | 1 |
| Yamadori, T | 1 |
| Mizoi, Y | 1 |
| Tanaka, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurovascular Mechanisms of Intermittent Hypoxia Induced Neural Plasticity[NCT05183113] | 43 participants (Actual) | Interventional | 2019-05-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketanserin and Chronic Disease
| Article | Year |
|---|---|
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis.
Topics: Abruptio Placentae; Amlodipine; Antihypertensive Agents; Atenolol; Cesarean Section; Chronic Disease | 2020 |
Effects of serotonin on airways: recent developments.
Topics: Allergy and Immunology; Animals; Bronchitis; Chronic Disease; Humans; Inflammation Mediators; Ketans | 1995 |
5 trials available for ketanserin and Chronic Disease
| Article | Year |
|---|---|
Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.
Topics: Administration, Cutaneous; Aged; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Foot; Double-B | 2006 |
Experience with ketanserin, a serotonin (S2) antagonist, in longterm treatment of essential hypertension.
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Female; Humans; Hypertension; Ketanserin; Ma | 1984 |
[Sleep disorders in chronic pain and generalized tendomyopathy].
Topics: Adult; Chronic Disease; Electroencephalography; Female; Fibromyalgia; Humans; Ketanserin; Male; Midd | 1995 |
Ketanserin promotes wound healing: clinical and preclinical results.
Topics: Aged; Chronic Disease; Double-Blind Method; Female; Granulation Tissue; Humans; Ketanserin; Leg Ulce | 1991 |
Ketanserin hypertension and chronic alcoholism DB study in 40 patients.
Topics: Alcoholism; Blood Pressure; Chronic Disease; Female; Humans; Hypertension; Ketanserin; Male; Piperid | 1985 |
10 other studies available for ketanserin and Chronic Disease
| Article | Year |
|---|---|
Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats.
Topics: Anesthesia; Animals; Blood Gas Analysis; Chronic Disease; Dizocilpine Maleate; Excitatory Amino Acid | 2010 |
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.
Topics: Analysis of Variance; Animals; Carrier Proteins; Chronic Disease; Citalopram; Disease Models, Animal | 2003 |
Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats.
Topics: Animals; Chronic Disease; Clozapine; Hypoxia; Ketanserin; Male; Methysergide; Rats; Rats, Sprague-Da | 2004 |
Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury.
Topics: Animals; Arteries; Blood Gas Analysis; Cell Count; Chronic Disease; Diagnostic Imaging; Hydrogen-Ion | 2005 |
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
Topics: Animals; Antidepressive Agents; Blotting, Northern; Chronic Disease; Electroshock; Frontal Lobe; Ket | 1993 |
Pharmacological characterization of coronary small arteries from pigs with chronic ischaemic myocardial remodelling.
Topics: Acetylcholine; Animals; Bradykinin; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Coronary Vess | 1998 |
[Serotonin receptors blocker ketanserin in the combined therapy of patients with chronic obstructive bronchitis].
Topics: Adult; Bronchitis; Bronchoalveolar Lavage Fluid; Chronic Disease; Epoprostenol; Female; Humans; Keta | 1991 |
Activity-wheel stress and serotonergic hypersensitivity in rats.
Topics: Animals; Cerebral Cortex; Chronic Disease; Hydroxyindoleacetic Acid; Ketanserin; Motor Activity; Phy | 1989 |
Chronic leg ulceration with livedoid vasculitis, and response to oral ketanserin.
Topics: Administration, Oral; Chronic Disease; Female; Humans; Ketanserin; Leg Ulcer; Middle Aged; Raynaud D | 1989 |
Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics.
Topics: Adult; Aged; Caudate Nucleus; Chronic Disease; Female; Frontal Lobe; Humans; Ketanserin; Male; Middl | 1986 |