Page last updated: 2024-10-29

ketanserin and Chronic Disease

ketanserin has been researched along with Chronic Disease in 17 studies

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers."9.12Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. ( Cauwenbergh, G; Kharfi, M; Paquet, P; Piérard, GE; Quatresooz, P; Vroome, V, 2006)
"Topical ketanserin is a valuable therapy for difficult-to-treat leg ulcers."5.12Healing effect of ketanserin on chronic leg ulcers in patients with diabetes. ( Cauwenbergh, G; Kharfi, M; Paquet, P; Piérard, GE; Quatresooz, P; Vroome, V, 2006)
" The incidence of severe hypertension was significantly lower when nifedipine (odds ratio, 0."5.05Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. ( Bellos, I; Daskalakis, G; Loutradis, D; Papapanagiotou, A; Pergialiotis, V, 2020)
" During exposure to hypoxia (10% O2 for 2 weeks), the animals received one of the specific 5-HTT inhibitors citalopram and fluoxetine (10 mg/kg/day), the selective 5-HT1B/1D receptor antagonist GR127935 (2 and 10 mg/kg/day), or the 5-HT2A receptor antagonist ketanserin (2 mg/kg/day)."3.72Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension. ( Adnot, S; Eddahibi, S; Hamon, M; Marcos, E; Nosjean, A; Pham, MH; Raffestin, B, 2003)
" In contrast, chronic administration of imipramine, mianserin, and tranylcypromine, treatments that decreased ligand binding, did not decrease levels of 5-HT2 receptor mRNA."1.29Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex. ( Butler, MO; Duman, RS; Morinobu, S, 1993)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19905 (29.41)18.7374
1990's6 (35.29)18.2507
2000's4 (23.53)29.6817
2010's1 (5.88)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Bellos, I1
Pergialiotis, V1
Papapanagiotou, A1
Loutradis, D1
Daskalakis, G1
Cao, Y1
Liu, C1
Ling, L2
Marcos, E1
Adnot, S1
Pham, MH1
Nosjean, A1
Raffestin, B1
Hamon, M1
Eddahibi, S1
McGuire, M1
Zhang, Y1
White, DP1
Golder, FJ1
Mitchell, GS1
Quatresooz, P1
Kharfi, M1
Paquet, P1
Vroome, V1
Cauwenbergh, G1
Piérard, GE1
Hedner, T1
Persson, B1
Berglund, G1
Cazzola, M1
Matera, MG1
D'Amato, G1
Rossi, F1
Butler, MO1
Morinobu, S1
Duman, RS1
Hemmeter, U1
Kocher, R1
Ladewig, D1
Hatzinger, M1
Seifritz, E1
Lauer, CJ1
Holsboer-Trachsler, E1
Buus, NH1
Terp, K1
Baandrup, U1
Mulvany, MJ1
Nyborg, NC1
Efimov, VV1
Blazhko, VI1
Voeĭkdova, LS1
Liashenko, MM1
Bondar', TN1
Rooman, RP1
Janssen, H1
Mayeda, AR1
Simon, JR1
Hingtgen, JN1
Hofstetter, JR1
Aprison, MH1
Rustin, MH1
Bunker, CB1
Dowd, PM1
De Lorenzo, A1
Ceccanti, M1
Assogna, G1
Romeo, M1
Cavalieri, G1
Attilia, ML1
Mita, T1
Hanada, S1
Nishino, N1
Kuno, T1
Nakai, H1
Yamadori, T1
Mizoi, Y1
Tanaka, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neurovascular Mechanisms of Intermittent Hypoxia Induced Neural Plasticity[NCT05183113]43 participants (Actual)Interventional2019-05-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for ketanserin and Chronic Disease

ArticleYear
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:4

    Topics: Abruptio Placentae; Amlodipine; Antihypertensive Agents; Atenolol; Cesarean Section; Chronic Disease

2020
Effects of serotonin on airways: recent developments.
    Allergy, 1995, Volume: 50, Issue:1

    Topics: Allergy and Immunology; Animals; Bronchitis; Chronic Disease; Humans; Inflammation Mediators; Ketans

1995

Trials

5 trials available for ketanserin and Chronic Disease

ArticleYear
Healing effect of ketanserin on chronic leg ulcers in patients with diabetes.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2006, Volume: 20, Issue:3

    Topics: Administration, Cutaneous; Aged; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Foot; Double-B

2006
Experience with ketanserin, a serotonin (S2) antagonist, in longterm treatment of essential hypertension.
    Clinical and experimental hypertension. Part A, Theory and practice, 1984, Volume: 6, Issue:3

    Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Female; Humans; Hypertension; Ketanserin; Ma

1984
[Sleep disorders in chronic pain and generalized tendomyopathy].
    Schweizerische medizinische Wochenschrift, 1995, Dec-09, Volume: 125, Issue:49

    Topics: Adult; Chronic Disease; Electroencephalography; Female; Fibromyalgia; Humans; Ketanserin; Male; Midd

1995
Ketanserin promotes wound healing: clinical and preclinical results.
    Progress in clinical and biological research, 1991, Volume: 365

    Topics: Aged; Chronic Disease; Double-Blind Method; Female; Granulation Tissue; Humans; Ketanserin; Leg Ulce

1991
Ketanserin hypertension and chronic alcoholism DB study in 40 patients.
    Bollettino chimico farmaceutico, 1985, Volume: 124, Issue:10

    Topics: Alcoholism; Blood Pressure; Chronic Disease; Female; Humans; Hypertension; Ketanserin; Male; Piperid

1985

Other Studies

10 other studies available for ketanserin and Chronic Disease

ArticleYear
Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats.
    Respiratory physiology & neurobiology, 2010, Feb-28, Volume: 170, Issue:2

    Topics: Anesthesia; Animals; Blood Gas Analysis; Chronic Disease; Dizocilpine Maleate; Excitatory Amino Acid

2010
Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.
    American journal of respiratory and critical care medicine, 2003, Aug-15, Volume: 168, Issue:4

    Topics: Analysis of Variance; Animals; Carrier Proteins; Chronic Disease; Citalopram; Disease Models, Animal

2003
Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 286, Issue:2

    Topics: Animals; Chronic Disease; Clozapine; Hypoxia; Ketanserin; Male; Methysergide; Rats; Rats, Sprague-Da

2004
Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-16, Volume: 25, Issue:11

    Topics: Animals; Arteries; Blood Gas Analysis; Cell Count; Chronic Disease; Diagnostic Imaging; Hydrogen-Ion

2005
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
    Journal of neurochemistry, 1993, Volume: 61, Issue:4

    Topics: Animals; Antidepressive Agents; Blotting, Northern; Chronic Disease; Electroshock; Frontal Lobe; Ket

1993
Pharmacological characterization of coronary small arteries from pigs with chronic ischaemic myocardial remodelling.
    Clinical science (London, England : 1979), 1998, Volume: 94, Issue:2

    Topics: Acetylcholine; Animals; Bradykinin; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Coronary Vess

1998
[Serotonin receptors blocker ketanserin in the combined therapy of patients with chronic obstructive bronchitis].
    Klinicheskaia meditsina, 1991, Volume: 69, Issue:5

    Topics: Adult; Bronchitis; Bronchoalveolar Lavage Fluid; Chronic Disease; Epoprostenol; Female; Humans; Keta

1991
Activity-wheel stress and serotonergic hypersensitivity in rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:2

    Topics: Animals; Cerebral Cortex; Chronic Disease; Hydroxyindoleacetic Acid; Ketanserin; Motor Activity; Phy

1989
Chronic leg ulceration with livedoid vasculitis, and response to oral ketanserin.
    The British journal of dermatology, 1989, Volume: 120, Issue:1

    Topics: Administration, Oral; Chronic Disease; Female; Humans; Ketanserin; Leg Ulcer; Middle Aged; Raynaud D

1989
Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics.
    Biological psychiatry, 1986, Volume: 21, Issue:14

    Topics: Adult; Aged; Caudate Nucleus; Chronic Disease; Female; Frontal Lobe; Humans; Ketanserin; Male; Middl

1986