Page last updated: 2024-10-29

ketanserin and Cardiomegaly

ketanserin has been researched along with Cardiomegaly in 7 studies

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
" Chronic administration of these antagonists strongly prevented exacerbation of ventricular hypertrophy in MAO-A KO mice."1.35Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. ( Bianchi, P; Calise, D; Escourrou, G; Galinier, M; Guilbeau-Frugier, C; Lairez, O; Mialet-Perez, J; Ordener, C; Parini, A; Pizzinat, N; Roncalli, J; Seif, I; Spreux-Varoquaux, O, 2009)
"Ketanserin treatment decreased mean left ventricular mass by 9."1.28Effects of ketanserin on left ventricular hypertrophy in hypertensive patients. ( Alcocer, L; Chávez, A; Cobo, C, 1990)
"Ketanserin is a serotonin antagonist with age-related antihypertensive efficacy."1.28Left ventricular hypertrophy regression and function changes with ketanserin in elderly hypertensives. ( Karpanou, EA; Kourtis, TK; Paleologos, AA; Pitsavos, CE; Toutouzas, PK; Vyssoulis, GP, 1990)
"Cotreatment with metergoline, an antagonist which binds to both 5-HT1 and 5-HT2 receptors, did not alter MCTP-induced elevation of lung weight or right ventricular hypertrophy."1.27Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin. ( Ganey, PE; Hadley, KB; Roth, RA; Sprugel, KH, 1986)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's5 (71.43)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lairez, O1
Calise, D1
Bianchi, P1
Ordener, C1
Spreux-Varoquaux, O1
Guilbeau-Frugier, C1
Escourrou, G1
Seif, I1
Roncalli, J1
Pizzinat, N1
Galinier, M1
Parini, A1
Mialet-Perez, J1
Buus, NH1
Terp, K1
Baandrup, U1
Mulvany, MJ1
Nyborg, NC1
Vyssoulis, GP2
Karpanou, EA2
Pitsavos, CE2
Kourtis, TK2
Paleologos, AA2
Toutouzas, PK2
Cobo, C1
Alcocer, L1
Chávez, A1
Coto, V1
Cocozza, M1
Oliviero, U1
Lucariello, A1
Picano, T1
Castaldo, B1
Iovino, V1
Cacciatore, L1
Ganey, PE1
Sprugel, KH1
Hadley, KB1
Roth, RA1

Other Studies

7 other studies available for ketanserin and Cardiomegaly

ArticleYear
Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload.
    Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:4

    Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Fibrosis; Fluorobenzenes; Gene Deletion; Gene Expressi

2009
Pharmacological characterization of coronary small arteries from pigs with chronic ischaemic myocardial remodelling.
    Clinical science (London, England : 1979), 1998, Volume: 94, Issue:2

    Topics: Acetylcholine; Animals; Bradykinin; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Coronary Vess

1998
Comparison of ketanserin and celiprolol on regression of left ventricular hypertrophy in older hypertensive patients.
    Cardiovascular drugs and therapy, 1992, Volume: 6, Issue:4

    Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cardiomegaly; Celiprolol; Echocardiography; Femal

1992
Effects of ketanserin on left ventricular hypertrophy in hypertensive patients.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 1

    Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Cholesterol; Electrocardiography; Female; Heart Rate; Hum

1990
Regression of left ventricular hypertrophy and systolic function in hypertensive patients during long-term treatment with ketanserin.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 1

    Topics: Adult; Angiocardiography; Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart Rate; Humans

1990
Left ventricular hypertrophy regression and function changes with ketanserin in elderly hypertensives.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 1

    Topics: Aged; Blood Pressure; Cardiac Output; Cardiomegaly; Echocardiography; Female; Heart Rate; Humans; Hy

1990
Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: Angiotensin II; Animals; Blood Platelets; Blood Pressure; Cardiomegaly; Ergolines; Ketanserin; Lung;

1986