ketanserin has been researched along with Cardiomegaly in 7 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration of these antagonists strongly prevented exacerbation of ventricular hypertrophy in MAO-A KO mice." | 1.35 | Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. ( Bianchi, P; Calise, D; Escourrou, G; Galinier, M; Guilbeau-Frugier, C; Lairez, O; Mialet-Perez, J; Ordener, C; Parini, A; Pizzinat, N; Roncalli, J; Seif, I; Spreux-Varoquaux, O, 2009) |
| "Ketanserin treatment decreased mean left ventricular mass by 9." | 1.28 | Effects of ketanserin on left ventricular hypertrophy in hypertensive patients. ( Alcocer, L; Chávez, A; Cobo, C, 1990) |
| "Ketanserin is a serotonin antagonist with age-related antihypertensive efficacy." | 1.28 | Left ventricular hypertrophy regression and function changes with ketanserin in elderly hypertensives. ( Karpanou, EA; Kourtis, TK; Paleologos, AA; Pitsavos, CE; Toutouzas, PK; Vyssoulis, GP, 1990) |
| "Cotreatment with metergoline, an antagonist which binds to both 5-HT1 and 5-HT2 receptors, did not alter MCTP-induced elevation of lung weight or right ventricular hypertrophy." | 1.27 | Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin. ( Ganey, PE; Hadley, KB; Roth, RA; Sprugel, KH, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lairez, O | 1 |
| Calise, D | 1 |
| Bianchi, P | 1 |
| Ordener, C | 1 |
| Spreux-Varoquaux, O | 1 |
| Guilbeau-Frugier, C | 1 |
| Escourrou, G | 1 |
| Seif, I | 1 |
| Roncalli, J | 1 |
| Pizzinat, N | 1 |
| Galinier, M | 1 |
| Parini, A | 1 |
| Mialet-Perez, J | 1 |
| Buus, NH | 1 |
| Terp, K | 1 |
| Baandrup, U | 1 |
| Mulvany, MJ | 1 |
| Nyborg, NC | 1 |
| Vyssoulis, GP | 2 |
| Karpanou, EA | 2 |
| Pitsavos, CE | 2 |
| Kourtis, TK | 2 |
| Paleologos, AA | 2 |
| Toutouzas, PK | 2 |
| Cobo, C | 1 |
| Alcocer, L | 1 |
| Chávez, A | 1 |
| Coto, V | 1 |
| Cocozza, M | 1 |
| Oliviero, U | 1 |
| Lucariello, A | 1 |
| Picano, T | 1 |
| Castaldo, B | 1 |
| Iovino, V | 1 |
| Cacciatore, L | 1 |
| Ganey, PE | 1 |
| Sprugel, KH | 1 |
| Hadley, KB | 1 |
| Roth, RA | 1 |
7 other studies available for ketanserin and Cardiomegaly
| Article | Year |
|---|---|
Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Fibrosis; Fluorobenzenes; Gene Deletion; Gene Expressi | 2009 |
Pharmacological characterization of coronary small arteries from pigs with chronic ischaemic myocardial remodelling.
Topics: Acetylcholine; Animals; Bradykinin; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Coronary Vess | 1998 |
Comparison of ketanserin and celiprolol on regression of left ventricular hypertrophy in older hypertensive patients.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cardiomegaly; Celiprolol; Echocardiography; Femal | 1992 |
Effects of ketanserin on left ventricular hypertrophy in hypertensive patients.
Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Cholesterol; Electrocardiography; Female; Heart Rate; Hum | 1990 |
Regression of left ventricular hypertrophy and systolic function in hypertensive patients during long-term treatment with ketanserin.
Topics: Adult; Angiocardiography; Blood Pressure; Cardiomegaly; Echocardiography; Female; Heart Rate; Humans | 1990 |
Left ventricular hypertrophy regression and function changes with ketanserin in elderly hypertensives.
Topics: Aged; Blood Pressure; Cardiac Output; Cardiomegaly; Echocardiography; Female; Heart Rate; Humans; Hy | 1990 |
Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin.
Topics: Angiotensin II; Animals; Blood Platelets; Blood Pressure; Cardiomegaly; Ergolines; Ketanserin; Lung; | 1986 |