ketanserin has been researched along with Arrhythmias, Cardiac in 11 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Digoxin inhibits the membrane-bound ATPase enzyme, resulting in a rise in intracellular sodium and activated outward potassium current, predisposing to arrhythmias." | 7.70 | Ketanserin inhibits digoxin-induced arrhythmias in the anaesthetized guinea-pig. ( Kalyoncu, NI; Ozyavuz, R, 1999) |
| "The effects of the 5-hydroxytryptamine2 (5-HT2) antagonists ketanserin and ritanserin on ischaemia- and reperfusion-induced arrhythmias were investigated in pentobarbitone-anaesthetised rats." | 7.67 | Ketanserin and ritanserin can reduce reperfusion-induced but not ischaemia-induced arrhythmias in anaesthetised rats. ( Coker, SJ; Ellis, AM, 1987) |
| "A patient is reported who developed a marked prolongation of QTc and life threatening ventricular arrhythmias during oral Ketanserin therapy." | 7.67 | Ventricular arrhythmias and QT-prolongation during therapy with ketanserin: report of a case. ( De Geest, H; Vandermotten, M; Verhaeghe, R, 1989) |
| "Efficacy and safety of ketanserin was studied prospectively in a randomized and double-blind trial involving 221 patients treated for hypertension and/or coronary artery disease." | 5.06 | Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin. Multicenter Ketanserin Research Group. ( Geibel, A; Hartung, J; Hohnloser, S; Just, H; Meinertz, T; Seiler, KU; Zehender, M, 1990) |
| "Efficacy and safety of ketanserin were studied prospectively in a randomized, double-blind trial involving 221 patients treated for hypertension or coronary artery disease, or both." | 5.06 | Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin. ( Geibel, A; Hartung, J; Hohnloser, S; Just, H; Meinertz, T; Seiler, KU; Zehender, M, 1989) |
| "Digoxin inhibits the membrane-bound ATPase enzyme, resulting in a rise in intracellular sodium and activated outward potassium current, predisposing to arrhythmias." | 3.70 | Ketanserin inhibits digoxin-induced arrhythmias in the anaesthetized guinea-pig. ( Kalyoncu, NI; Ozyavuz, R, 1999) |
| "Ketanserin and calcium antagonists are frequently used for the treatment of arterial hypertension in the elderly." | 3.68 | [Cardiac interactions between ketanserin and the calcium antagonist nifedipine]. ( Alberio, L; Beretta-Piccoli, C; Koch, P; Tanzi, F; Zehender, M, 1992) |
| "The effects of the 5-hydroxytryptamine2 (5-HT2) antagonists ketanserin and ritanserin on ischaemia- and reperfusion-induced arrhythmias were investigated in pentobarbitone-anaesthetised rats." | 3.67 | Ketanserin and ritanserin can reduce reperfusion-induced but not ischaemia-induced arrhythmias in anaesthetised rats. ( Coker, SJ; Ellis, AM, 1987) |
| "A patient is reported who developed a marked prolongation of QTc and life threatening ventricular arrhythmias during oral Ketanserin therapy." | 3.67 | Ventricular arrhythmias and QT-prolongation during therapy with ketanserin: report of a case. ( De Geest, H; Vandermotten, M; Verhaeghe, R, 1989) |
| "Ketanserin treatment is also associated with prolongation of the corrected QT interval." | 2.67 | The effects of ketanserin on ventricular ectopic activity in humans. ( Dews, I; Gould, SE; Marks, C; Stephens, J; VandenBurg, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coha, B | 1 |
| Samardžić, P | 1 |
| Dundjer, I | 1 |
| Knežević-Praveček, M | 1 |
| Kalyoncu, NI | 1 |
| Ozyavuz, R | 1 |
| Alberio, L | 1 |
| Beretta-Piccoli, C | 1 |
| Tanzi, F | 1 |
| Koch, P | 1 |
| Zehender, M | 3 |
| Noble, MI | 1 |
| Drake-Holland, AJ | 1 |
| Meinertz, T | 2 |
| Hohnloser, S | 2 |
| Geibel, A | 2 |
| Hartung, J | 2 |
| Seiler, KU | 2 |
| Just, H | 2 |
| Marks, C | 1 |
| Dews, I | 1 |
| Gould, SE | 1 |
| Stephens, J | 1 |
| VandenBurg, M | 1 |
| Saman, S | 1 |
| Thandroyen, F | 1 |
| Opie, LH | 1 |
| Aldariz, AE | 1 |
| Romero, H | 1 |
| Baroni, M | 1 |
| Baglivo, H | 1 |
| Esper, RJ | 1 |
| Coker, SJ | 1 |
| Ellis, AM | 1 |
| Vandermotten, M | 1 |
| Verhaeghe, R | 1 |
| De Geest, H | 1 |
2 reviews available for ketanserin and Arrhythmias, Cardiac
| Article | Year |
|---|---|
The possible role of serotonin 5HT2 receptor antagonism in cardioprotection.
Topics: Arrhythmias, Cardiac; Blood Vessels; Coronary Thrombosis; Endothelium, Vascular; Humans; Ketanserin; | 1992 |
Serotonin and the heart: effects of ketanserin on myocardial function, heart rate, and arrhythmias.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Coronary Circulation; Coronary Disease; Heart; Hea | 1985 |
3 trials available for ketanserin and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin. Multicenter Ketanserin Research Group.
Topics: Aged; Arrhythmias, Cardiac; Coronary Disease; Double-Blind Method; Electrocardiography; Female; Hemo | 1990 |
The effects of ketanserin on ventricular ectopic activity in humans.
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Double-Blind Method; Electrocardiography; Female; | 1990 |
Incidence and clinical relevance of QT prolongation caused by the new selective serotonin antagonist ketanserin.
Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Fema | 1989 |
6 other studies available for ketanserin and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Cardiac arrhythmia as a side effect of ketanserin therapy in a patient with systemic scleroderma.
Topics: Arrhythmias, Cardiac; Electrocardiography, Ambulatory; Female; Humans; Ketanserin; Middle Aged; Scle | 2012 |
Ketanserin inhibits digoxin-induced arrhythmias in the anaesthetized guinea-pig.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Digoxin; Dose-Response Relat | 1999 |
[Cardiac interactions between ketanserin and the calcium antagonist nifedipine].
Topics: Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiac Complexes, Premature; Drug Interactions; Drug Th | 1992 |
QT prolongation and torsade de pointes ventricular tachycardia produced by Ketanserin.
Topics: Adult; Aged; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Ketanserin; Long QT Syndrome | 1986 |
Ketanserin and ritanserin can reduce reperfusion-induced but not ischaemia-induced arrhythmias in anaesthetised rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Female; Guinea Pigs; Ketans | 1987 |
Ventricular arrhythmias and QT-prolongation during therapy with ketanserin: report of a case.
Topics: Administration, Oral; Aged; Arrhythmias, Cardiac; Electrocardiography; Humans; Ketanserin; Long QT S | 1989 |