ketanserin and Anesthesia
ketanserin has been researched along with Anesthesia in 27 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "To improve the pharmacological characterization of the receptors mediating 5-hydroxytryptamine (5-HT)-induced apnea the inhibitory effects of exogenous 5-HT on respiration and phrenic nerve activity (PNA) were studied in anesthetized rats." | 7.68 | Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. ( Goda, Y; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M, 1992) |
| "The effects of topical and intracameral serotonin and topical, intracameral and intravenous selective (5-HT2) serotonin antagonist, ketanserin, on the intraocular pressure (IOP) were studied in the rabbit." | 7.67 | Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit. ( Krootila, K; Palkama, A; Uusitalo, H, 1987) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "To improve the pharmacological characterization of the receptors mediating 5-hydroxytryptamine (5-HT)-induced apnea the inhibitory effects of exogenous 5-HT on respiration and phrenic nerve activity (PNA) were studied in anesthetized rats." | 3.68 | Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. ( Goda, Y; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M, 1992) |
| "The effects of topical and intracameral serotonin and topical, intracameral and intravenous selective (5-HT2) serotonin antagonist, ketanserin, on the intraocular pressure (IOP) were studied in the rabbit." | 3.67 | Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit. ( Krootila, K; Palkama, A; Uusitalo, H, 1987) |
| "New publications on malignant hyperthermia (MH), with direct clinical importance, are reported." | 2.37 | [New findings and experiences in the field of malignant hyperthermia]. ( Eberlein, HJ; Schulte-Sasse, U, 1986) |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (40.74) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Elbers, PW | 1 |
| Ozdemir, A | 1 |
| van Iterson, M | 1 |
| van Dongen, EP | 1 |
| Ince, C | 1 |
| Cao, Y | 1 |
| Liu, C | 1 |
| Ling, L | 1 |
| Liu, J | 1 |
| Wei, X | 1 |
| Zhao, C | 1 |
| Hu, S | 1 |
| Duan, J | 1 |
| Ju, G | 1 |
| Wong-Riley, MT | 1 |
| Liu, Y | 1 |
| Chang, CP | 1 |
| Chen, SH | 1 |
| Lin, MT | 1 |
| Fu, YJ | 1 |
| Wang, WZ | 1 |
| Cai, GJ | 1 |
| Wang, MW | 1 |
| Su, DF | 1 |
| van den Broeke, JJ | 1 |
| Karliczek, GF | 1 |
| Brenken, U | 1 |
| Schokkenbroek, R | 1 |
| Homan van der Heide, JN | 1 |
| Van der Starre, PJ | 1 |
| Reneman, RS | 1 |
| Olsen, KS | 2 |
| Fink, G | 1 |
| Dow, RC | 1 |
| McQueen, JK | 1 |
| Bennie, JG | 1 |
| Carroll, SM | 1 |
| Knowles, ID | 1 |
| Ramage, AG | 2 |
| N'Diaye, A | 1 |
| Sévoz-Couche, C | 1 |
| Nosjean, A | 1 |
| Hamon, M | 1 |
| Laguzzi, R | 1 |
| Henriksen, L | 1 |
| Dige-Petersen, H | 1 |
| Chraemmer-Jørgensen, B | 1 |
| Rosenørn, J | 1 |
| Yoshioka, M | 1 |
| Goda, Y | 1 |
| Togashi, H | 1 |
| Matsumoto, M | 1 |
| Saito, H | 1 |
| Perren, MJ | 1 |
| Feniuk, W | 1 |
| Humphrey, PP | 1 |
| Takahashi, T | 1 |
| Hisa, H | 1 |
| Satoh, S | 1 |
| Lewis, DI | 1 |
| Coote, JH | 1 |
| Woodman, OL | 1 |
| Docherty, JR | 1 |
| Hughes, EW | 1 |
| Hodkinson, BP | 1 |
| Aono, J | 1 |
| Nabata, H | 1 |
| Ishizuka, N | 1 |
| Sakai, K | 1 |
| Schrauwen, E | 1 |
| Houvenaghel, A | 1 |
| Nalda, MA | 1 |
| Gomar, C | 1 |
| Luis, M | 1 |
| Schulte-Sasse, U | 1 |
| Eberlein, HJ | 1 |
| van de Water, A | 1 |
| Wouters, L | 1 |
| Xhonneux, R | 1 |
| Reneman, S | 1 |
| Yokoyama, K | 1 |
| Inada, Y | 1 |
| Shimizu, R | 1 |
| Fujita, M | 1 |
| Kaya, K | 1 |
| Krootila, K | 1 |
| Palkama, A | 1 |
| Uusitalo, H | 1 |
Reviews
2 reviews available for ketanserin and Anesthesia
| Article | Year |
|---|---|
The role of serotonin blockers in cardiac anesthesia.
Topics: Anesthesia; Cardiac Surgical Procedures; Humans; Ketanserin; Serotonin | 1994 |
[New findings and experiences in the field of malignant hyperthermia].
Topics: Anesthesia; Animals; Calcium Channel Blockers; Catatonia; Dantrolene; Diagnosis, Differential; Human | 1986 |
Trials
1 trial available for ketanserin and Anesthesia
| Article | Year |
|---|---|
The effect of ketanserin on post-anaesthetic vasoconstriction and shivering.
Topics: Adult; Anesthesia; Blood Gas Analysis; Blood Pressure; Body Temperature; Female; Heart Rate; Humans; | 1985 |
Other Studies
24 other studies available for ketanserin and Anesthesia
| Article | Year |
|---|---|
Microcirculatory imaging in cardiac anesthesia: ketanserin reduces blood pressure but not perfused capillary density.
Topics: Adult; Aged; Anesthesia; Blood Pressure; Capillaries; Cardiac Surgical Procedures; Cardiovascular Di | 2009 |
Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats.
Topics: Anesthesia; Animals; Blood Gas Analysis; Chronic Disease; Dizocilpine Maleate; Excitatory Amino Acid | 2010 |
5-HT induces enhanced phrenic nerve activity via 5-HT(2A) receptor/PKC mechanism in anesthetized rats.
Topics: Anesthesia; Animals; Carotid Body; Female; Gene Expression Regulation; Isoenzymes; Ketanserin; Male; | 2011 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Action site of ketanserin enhancing baroreflex function is within the rostral ventrolateral medulla in anesthetized rats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; | 2006 |
Is prevention of hypertension after open heart surgery possible by blocking 5HT2-receptors with ketanserin?
Topics: Adult; Aged; Anesthesia; Aortic Valve; Coronary Artery Bypass; Heart Valve Prosthesis; Hemodynamics; | 1982 |
The influence of ketanserin on intracerebral haemodynamics--with special reference to neuroanaesthesia.
Topics: Anesthesia; Antihypertensive Agents; Brain; Cerebrovascular Circulation; Hemodynamics; Homeostasis; | 1998 |
Serotonergic 5-HT2A receptors important for the oestradiol-induced surge of luteinising hormone-releasing hormone in the rat.
Topics: Anesthesia; Anesthetics; Animals; Cyclic S-Oxides; Diestrus; Estradiol; Female; Fluoxetine; Gonadotr | 1999 |
Evidence that activation of central 5-HT(2B) receptors causes renal sympathoexcitation in anaesthetized rats.
Topics: Amidines; Anesthesia; Animals; Blood Pressure; Heart Rate; Indoles; Injections, Intraventricular; Ke | 2000 |
Stimulation of 5-HT2 receptors in the nucleus tractus solitarius enhances NMDA receptor-mediated reflex-evoked bradycardiac responses in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amphetamines; Anesthesia; Animals; Blood Pressure; Bradycardia; Chemore | 2001 |
Effect of ketanserin on global cerebral blood flow and cerebral oxygen metabolism during midazolam-fentanyl or isoflurane anaesthesia.
Topics: Adult; Anesthesia; Brain; Cerebrovascular Circulation; Female; Fentanyl; Humans; Intervertebral Disc | 1992 |
Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat.
Topics: Anesthesia; Animals; Apnea; Bronchoconstriction; Drug Interactions; Imidazoles; Ketanserin; Male; Me | 1992 |
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Atropine; Carotid Arteries; Dogs; Gangl | 1991 |
Serotonin-induced renin release in the dog kidney.
Topics: Anesthesia; Animals; Blood Pressure; Cyclooxygenase Inhibitors; Dogs; Female; Heart Rate; Indomethac | 1991 |
The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo.
Topics: Anesthesia; Animals; Electric Stimulation; Ergolines; Ganglia, Sympathetic; Homocysteine; Indoles; I | 1990 |
Enhanced coronary vasoconstrictor responses to 5-hydroxytryptamine in the presence of a coronary artery stenosis in anaesthetized dogs.
Topics: Anesthesia; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Electrocardiogr | 1990 |
An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anesthetized spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Ergolines; Heart Rate; | 1989 |
Carcinoid syndrome: the combined use of ketanserin and octreotide in the management of an acute crisis during anaesthesia.
Topics: Anesthesia; Breast Neoplasms; Carcinoid Tumor; Female; Humans; Hypertension; Intraoperative Complica | 1989 |
Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Decerebrate State; Gastr | 1985 |
The effects of ketanserin, methysergide and LY 53857 on sympathetic nerve activity.
Topics: Anesthesia; Animals; Blood Pressure; Cats; Ergolines; Heart Rate; Hemodynamics; Ketanserin; Lactates | 1985 |
Hemodynamic evaluation of endotoxic shock in anesthetized piglets: antagonism of endogenous vasoactive substances.
Topics: Adrenal Cortex Hormones; Anesthesia; Animals; Bacterial Toxins; Blood Pressure; Cardiac Output; Ente | 1985 |
Cardiovascular effects of ketanserin in closed-chest anesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Dogs; Electrocardiography; Female; Heart Rate; Hemodynamics; Ke | 1985 |
[Clinical evaluation of KJK-945 (ketanserin) on a multicenter basis].
Topics: Anesthesia; Evaluation Studies as Topic; Female; Humans; Hypertension; Ketanserin; Male; Middle Aged | 1987 |
Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit.
Topics: Anesthesia; Animals; Aqueous Humor; Eye; Eye Proteins; Female; Injections; Injections, Intravenous; | 1987 |