Page last updated: 2024-10-29

ketanserin and Anesthesia

ketanserin has been researched along with Anesthesia in 27 studies

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model."7.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"To improve the pharmacological characterization of the receptors mediating 5-hydroxytryptamine (5-HT)-induced apnea the inhibitory effects of exogenous 5-HT on respiration and phrenic nerve activity (PNA) were studied in anesthetized rats."7.68Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. ( Goda, Y; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M, 1992)
"The effects of topical and intracameral serotonin and topical, intracameral and intravenous selective (5-HT2) serotonin antagonist, ketanserin, on the intraocular pressure (IOP) were studied in the rabbit."7.67Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit. ( Krootila, K; Palkama, A; Uusitalo, H, 1987)
"We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model."3.73Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005)
"To improve the pharmacological characterization of the receptors mediating 5-hydroxytryptamine (5-HT)-induced apnea the inhibitory effects of exogenous 5-HT on respiration and phrenic nerve activity (PNA) were studied in anesthetized rats."3.68Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. ( Goda, Y; Matsumoto, M; Saito, H; Togashi, H; Yoshioka, M, 1992)
"The effects of topical and intracameral serotonin and topical, intracameral and intravenous selective (5-HT2) serotonin antagonist, ketanserin, on the intraocular pressure (IOP) were studied in the rabbit."3.67Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit. ( Krootila, K; Palkama, A; Uusitalo, H, 1987)
"New publications on malignant hyperthermia (MH), with direct clinical importance, are reported."2.37[New findings and experiences in the field of malignant hyperthermia]. ( Eberlein, HJ; Schulte-Sasse, U, 1986)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199011 (40.74)18.7374
1990's9 (33.33)18.2507
2000's5 (18.52)29.6817
2010's2 (7.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elbers, PW1
Ozdemir, A1
van Iterson, M1
van Dongen, EP1
Ince, C1
Cao, Y1
Liu, C1
Ling, L1
Liu, J1
Wei, X1
Zhao, C1
Hu, S1
Duan, J1
Ju, G1
Wong-Riley, MT1
Liu, Y1
Chang, CP1
Chen, SH1
Lin, MT1
Fu, YJ1
Wang, WZ1
Cai, GJ1
Wang, MW1
Su, DF1
van den Broeke, JJ1
Karliczek, GF1
Brenken, U1
Schokkenbroek, R1
Homan van der Heide, JN1
Van der Starre, PJ1
Reneman, RS1
Olsen, KS2
Fink, G1
Dow, RC1
McQueen, JK1
Bennie, JG1
Carroll, SM1
Knowles, ID1
Ramage, AG2
N'Diaye, A1
Sévoz-Couche, C1
Nosjean, A1
Hamon, M1
Laguzzi, R1
Henriksen, L1
Dige-Petersen, H1
Chraemmer-Jørgensen, B1
Rosenørn, J1
Yoshioka, M1
Goda, Y1
Togashi, H1
Matsumoto, M1
Saito, H1
Perren, MJ1
Feniuk, W1
Humphrey, PP1
Takahashi, T1
Hisa, H1
Satoh, S1
Lewis, DI1
Coote, JH1
Woodman, OL1
Docherty, JR1
Hughes, EW1
Hodkinson, BP1
Aono, J1
Nabata, H1
Ishizuka, N1
Sakai, K1
Schrauwen, E1
Houvenaghel, A1
Nalda, MA1
Gomar, C1
Luis, M1
Schulte-Sasse, U1
Eberlein, HJ1
van de Water, A1
Wouters, L1
Xhonneux, R1
Reneman, S1
Yokoyama, K1
Inada, Y1
Shimizu, R1
Fujita, M1
Kaya, K1
Krootila, K1
Palkama, A1
Uusitalo, H1

Reviews

2 reviews available for ketanserin and Anesthesia

ArticleYear
The role of serotonin blockers in cardiac anesthesia.
    Journal of cardiothoracic and vascular anesthesia, 1994, Volume: 8, Issue:4

    Topics: Anesthesia; Cardiac Surgical Procedures; Humans; Ketanserin; Serotonin

1994
[New findings and experiences in the field of malignant hyperthermia].
    Der Anaesthesist, 1986, Volume: 35, Issue:1

    Topics: Anesthesia; Animals; Calcium Channel Blockers; Catatonia; Dantrolene; Diagnosis, Differential; Human

1986

Trials

1 trial available for ketanserin and Anesthesia

ArticleYear
The effect of ketanserin on post-anaesthetic vasoconstriction and shivering.
    European journal of anaesthesiology, 1985, Volume: 2, Issue:3

    Topics: Adult; Anesthesia; Blood Gas Analysis; Blood Pressure; Body Temperature; Female; Heart Rate; Humans;

1985

Other Studies

24 other studies available for ketanserin and Anesthesia

ArticleYear
Microcirculatory imaging in cardiac anesthesia: ketanserin reduces blood pressure but not perfused capillary density.
    Journal of cardiothoracic and vascular anesthesia, 2009, Volume: 23, Issue:1

    Topics: Adult; Aged; Anesthesia; Blood Pressure; Capillaries; Cardiac Surgical Procedures; Cardiovascular Di

2009
Glossopharyngeal long-term facilitation requires serotonin 5-HT2 and NMDA receptors in rats.
    Respiratory physiology & neurobiology, 2010, Feb-28, Volume: 170, Issue:2

    Topics: Anesthesia; Animals; Blood Gas Analysis; Chronic Disease; Dizocilpine Maleate; Excitatory Amino Acid

2010
5-HT induces enhanced phrenic nerve activity via 5-HT(2A) receptor/PKC mechanism in anesthetized rats.
    European journal of pharmacology, 2011, Apr-25, Volume: 657, Issue:1-3

    Topics: Anesthesia; Animals; Carotid Body; Female; Gene Expression Regulation; Isoenzymes; Ketanserin; Male;

2011
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
    Shock (Augusta, Ga.), 2005, Volume: 24, Issue:4

    Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid;

2005
Action site of ketanserin enhancing baroreflex function is within the rostral ventrolateral medulla in anesthetized rats.
    Autonomic neuroscience : basic & clinical, 2006, Jan-30, Volume: 124, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure;

2006
Is prevention of hypertension after open heart surgery possible by blocking 5HT2-receptors with ketanserin?
    Acta anaesthesiologica Belgica, 1982, Volume: 33, Issue:2

    Topics: Adult; Aged; Anesthesia; Aortic Valve; Coronary Artery Bypass; Heart Valve Prosthesis; Hemodynamics;

1982
The influence of ketanserin on intracerebral haemodynamics--with special reference to neuroanaesthesia.
    Danish medical bulletin, 1998, Volume: 45, Issue:1

    Topics: Anesthesia; Antihypertensive Agents; Brain; Cerebrovascular Circulation; Hemodynamics; Homeostasis;

1998
Serotonergic 5-HT2A receptors important for the oestradiol-induced surge of luteinising hormone-releasing hormone in the rat.
    Journal of neuroendocrinology, 1999, Volume: 11, Issue:1

    Topics: Anesthesia; Anesthetics; Animals; Cyclic S-Oxides; Diestrus; Estradiol; Female; Fluoxetine; Gonadotr

1999
Evidence that activation of central 5-HT(2B) receptors causes renal sympathoexcitation in anaesthetized rats.
    British journal of pharmacology, 2000, Volume: 129, Issue:1

    Topics: Amidines; Anesthesia; Animals; Blood Pressure; Heart Rate; Indoles; Injections, Intraventricular; Ke

2000
Stimulation of 5-HT2 receptors in the nucleus tractus solitarius enhances NMDA receptor-mediated reflex-evoked bradycardiac responses in the rat.
    Autonomic neuroscience : basic & clinical, 2001, Sep-17, Volume: 92, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Amphetamines; Anesthesia; Animals; Blood Pressure; Bradycardia; Chemore

2001
Effect of ketanserin on global cerebral blood flow and cerebral oxygen metabolism during midazolam-fentanyl or isoflurane anaesthesia.
    British journal of anaesthesia, 1992, Volume: 69, Issue:3

    Topics: Adult; Anesthesia; Brain; Cerebrovascular Circulation; Female; Fentanyl; Humans; Intervertebral Disc

1992
Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Anesthesia; Animals; Apnea; Bronchoconstriction; Drug Interactions; Imidazoles; Ketanserin; Male; Me

1992
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype.
    British journal of pharmacology, 1991, Volume: 102, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Atropine; Carotid Arteries; Dogs; Gangl

1991
Serotonin-induced renin release in the dog kidney.
    European journal of pharmacology, 1991, Feb-14, Volume: 193, Issue:3

    Topics: Anesthesia; Animals; Blood Pressure; Cyclooxygenase Inhibitors; Dogs; Female; Heart Rate; Indomethac

1991
The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo.
    British journal of pharmacology, 1990, Volume: 99, Issue:4

    Topics: Anesthesia; Animals; Electric Stimulation; Ergolines; Ganglia, Sympathetic; Homocysteine; Indoles; I

1990
Enhanced coronary vasoconstrictor responses to 5-hydroxytryptamine in the presence of a coronary artery stenosis in anaesthetized dogs.
    British journal of pharmacology, 1990, Volume: 100, Issue:1

    Topics: Anesthesia; Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Electrocardiogr

1990
An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anesthetized spontaneously hypertensive rats.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Ergolines; Heart Rate;

1989
Carcinoid syndrome: the combined use of ketanserin and octreotide in the management of an acute crisis during anaesthesia.
    Anaesthesia and intensive care, 1989, Volume: 17, Issue:3

    Topics: Anesthesia; Breast Neoplasms; Carcinoid Tumor; Female; Humans; Hypertension; Intraoperative Complica

1989
Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 277, Issue:1

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Decerebrate State; Gastr

1985
The effects of ketanserin, methysergide and LY 53857 on sympathetic nerve activity.
    European journal of pharmacology, 1985, Jul-31, Volume: 113, Issue:3

    Topics: Anesthesia; Animals; Blood Pressure; Cats; Ergolines; Heart Rate; Hemodynamics; Ketanserin; Lactates

1985
Hemodynamic evaluation of endotoxic shock in anesthetized piglets: antagonism of endogenous vasoactive substances.
    Circulatory shock, 1985, Volume: 16, Issue:1

    Topics: Adrenal Cortex Hormones; Anesthesia; Animals; Bacterial Toxins; Blood Pressure; Cardiac Output; Ente

1985
Cardiovascular effects of ketanserin in closed-chest anesthetized dogs.
    Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 275, Issue:2

    Topics: Anesthesia; Animals; Blood Pressure; Dogs; Electrocardiography; Female; Heart Rate; Hemodynamics; Ke

1985
[Clinical evaluation of KJK-945 (ketanserin) on a multicenter basis].
    Masui. The Japanese journal of anesthesiology, 1987, Volume: 36, Issue:8

    Topics: Anesthesia; Evaluation Studies as Topic; Female; Humans; Hypertension; Ketanserin; Male; Middle Aged

1987
Effect of serotonin and its antagonist (ketanserin) on intraocular pressure in the rabbit.
    Journal of ocular pharmacology, 1987,Winter, Volume: 3, Issue:4

    Topics: Anesthesia; Animals; Aqueous Humor; Eye; Eye Proteins; Female; Injections; Injections, Intravenous;

1987