ketanserin and Aging
ketanserin has been researched along with Aging in 52 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirteen men, age 60 +/- 2 years (mean +/- SEM) with mild hypertension, 151 +/- 4/95 +/- 3 mm Hg, completed a randomized, double-blind, placebo-controlled crossover trial of ketanserin therapy." | 9.06 | Effects of ketanserin on blood pressure and platelet aggregation in elderly men with mild hypertension. ( Campbell, R; Conlon, ME; Egan, B; Julius, S; Schork, N; Zwiefler, A, 1988) |
| "To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats." | 7.69 | Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996) |
| "Treatment with ketanserin caused hypotension, enhanced bradycardia, attenuated reflex tachycardia, and reversed serotonin (5-HT) responses, with all effects being more pronounced in 24-month-old rats than in younger rats." | 5.30 | Does chronic ketanserin treatment enhance bradycardia in old rats by serotonergic blockade? ( Buñag, RD; Davidow, LW, 1998) |
| "Ketanserin treatment lowered blood pressure consistently, and the ensuing hypotension was more pronounced in 14- and 24-month than in 4-month-old rats." | 5.29 | Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. ( Buñag, RD; Davidow, LW; Schmitz, TM, 1994) |
| "Thirteen men, age 60 +/- 2 years (mean +/- SEM) with mild hypertension, 151 +/- 4/95 +/- 3 mm Hg, completed a randomized, double-blind, placebo-controlled crossover trial of ketanserin therapy." | 5.06 | Effects of ketanserin on blood pressure and platelet aggregation in elderly men with mild hypertension. ( Campbell, R; Conlon, ME; Egan, B; Julius, S; Schork, N; Zwiefler, A, 1988) |
| " Thirty men and twenty-two women aged between 21 and 79 years were investigated with magnetic resonance imaging (MRI) and [(18)F]-altanserin positron emission tomography (PET)." | 3.72 | A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables. ( Adams, KH; Frøkjaer, V; Hasselbalch, SG; Haugbøl, S; Holm, S; Knudsen, GM; Madsen, K; Martiny, L; Paulson, OB; Pinborg, LH; Svarer, C, 2004) |
| "To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats." | 3.69 | Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996) |
| " Furthermore, aging does not seem to be associated with a reduced cortical serotonergic innervation, as indicated by the stability of the [3H]paroxetine-labeled 5-HT uptake sites." | 3.68 | Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. ( Arranz, B; Eriksson, A; Marcusson, J; Mellerup, E; Plenge, P, 1993) |
| "Both normal and genetically dystonic (dt) rats show a high-frequency forepaw tremor in response to systemic administration of the serotonin (5-HT) agonist quipazine at 8 days of age." | 3.68 | Enhanced sensitivity to quipazine in the genetically dystonic rat (dt). ( Lorden, JF; Michela, VL; Stratton, SE, 1990) |
| "Ketanserin is a serotonin S2-receptor antagonist introduced for the treatment of arterial hypertension and vasospastic disorders." | 2.38 | Clinical pharmacokinetics of ketanserin. ( Hedner, T; Heykants, J; Persson, B, 1991) |
| "The influence of ageing on the passive and active tension and pharmacodynamic characteristics of intramural coronary arteries from 3-month-old and 2-year-old male Wistar rats was investigated using an isometric myograph." | 1.38 | Effect of ageing on the passive and active tension and pharmacodynamic characteristics of rat coronary arteries: age-dependent increase in sensitivity to 5-HT and K+. ( Boonen, HC; Nyborg, NC; Outzen, EM; Sheykhzade, M; Simonsen, AH, 2012) |
| "Treatment with ketanserin caused hypotension, enhanced bradycardia, attenuated reflex tachycardia, and reversed serotonin (5-HT) responses, with all effects being more pronounced in 24-month-old rats than in younger rats." | 1.30 | Does chronic ketanserin treatment enhance bradycardia in old rats by serotonergic blockade? ( Buñag, RD; Davidow, LW, 1998) |
| " Long-term administration of KKT resulted in decreases in [3H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [3H]ketanserine binding to the caudate/putamen in young rats." | 1.29 | Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding. ( Hasegawa, T; Hayashi, T; Ishihara, S; Kameyama, T; Kaneyuki, T; Morimasa, T; Nabeshima, T; Shohmori, T; Yamada, K, 1994) |
| "Ketanserin treatment lowered blood pressure consistently, and the ensuing hypotension was more pronounced in 14- and 24-month than in 4-month-old rats." | 1.29 | Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. ( Buñag, RD; Davidow, LW; Schmitz, TM, 1994) |
| "Ten patients with bipolar mood disorders and 21 normal controls were studied in the drug-free state." | 1.28 | D1 dopamine receptor binding in mood disorders measured by positron emission tomography. ( Fukuda, H; Inoue, O; Mori, A; Nakayama, K; Shimizu, M; Suhara, T; Tateno, Y, 1992) |
| "Ketanserin is a serotonin S2-receptor antagonist that is an effective antihypertensive agent with a greater blood pressure reduction in older patients." | 1.28 | Could the increased antihypertensive efficacy of ketanserin in the elderly be due to altered pharmacokinetics? ( Gould, SE; Hosie, J; Silas, JH, 1990) |
Research
Studies (52)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (26.92) | 18.7374 |
| 1990's | 30 (57.69) | 18.2507 |
| 2000's | 6 (11.54) | 29.6817 |
| 2010's | 2 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Lim, I | 1 |
| Chess-Williams, R | 1 |
| Sellers, D | 1 |
| Sheykhzade, M | 1 |
| Simonsen, AH | 1 |
| Boonen, HC | 1 |
| Outzen, EM | 1 |
| Nyborg, NC | 2 |
| Adams, KH | 1 |
| Pinborg, LH | 2 |
| Svarer, C | 2 |
| Hasselbalch, SG | 2 |
| Holm, S | 2 |
| Haugbøl, S | 2 |
| Madsen, K | 2 |
| Frøkjaer, V | 1 |
| Martiny, L | 1 |
| Paulson, OB | 2 |
| Knudsen, GM | 2 |
| Frøkjaer, VG | 1 |
| Crow, TJ | 1 |
| Cross, AJ | 1 |
| Cooper, SJ | 1 |
| Deakin, JF | 1 |
| Ferrier, IN | 1 |
| Johnson, JA | 1 |
| Joseph, MH | 1 |
| Owen, F | 1 |
| Poulter, M | 1 |
| Lofthouse, R | 1 |
| Marcusson, JO | 1 |
| Morgan, DG | 1 |
| Winblad, B | 1 |
| Finch, CE | 1 |
| De Clerck, F | 1 |
| Jageneau, A | 1 |
| Dom, J | 1 |
| Burnet, PW | 1 |
| Eastwood, SL | 1 |
| Harrison, PJ | 1 |
| Robson, L | 1 |
| Gower, AJ | 1 |
| Kendall, DA | 1 |
| Marsden, CA | 1 |
| Gu, Q | 1 |
| Singer, W | 1 |
| Ishihara, S | 1 |
| Yamada, K | 1 |
| Hayashi, T | 1 |
| Hasegawa, T | 1 |
| Kameyama, T | 1 |
| Morimasa, T | 1 |
| Kaneyuki, T | 1 |
| Shohmori, T | 1 |
| Nabeshima, T | 1 |
| Davidow, LW | 3 |
| Schmitz, TM | 1 |
| Buñag, RD | 4 |
| Waeber, C | 1 |
| Palacios, JM | 1 |
| Docherty, JR | 1 |
| Wedderburn, JF | 1 |
| Sillar, KT | 1 |
| Kaminski, D | 1 |
| Weiner, N | 1 |
| Sturm, G | 1 |
| Wesemann, W | 1 |
| Arranz, B | 1 |
| Eriksson, A | 1 |
| Mellerup, E | 1 |
| Plenge, P | 1 |
| Marcusson, J | 1 |
| Sharma, HS | 1 |
| Westman, J | 1 |
| Navarro, JC | 1 |
| Dey, PK | 1 |
| Nyberg, F | 1 |
| Laporte, AM | 1 |
| Doyen, C | 1 |
| Nevo, IT | 1 |
| Chauveau, J | 1 |
| Hauw, JJ | 1 |
| Hamon, M | 1 |
| Rosier, A | 1 |
| Dupont, P | 1 |
| Peuskens, J | 1 |
| Bormans, G | 1 |
| Vandenberghe, R | 1 |
| Maes, M | 1 |
| de Groot, T | 1 |
| Schiepers, C | 1 |
| Verbruggen, A | 1 |
| Mortelmans, L | 1 |
| Jäkälä, P | 1 |
| Riekkinen, P | 1 |
| Moyanova, S | 2 |
| Kortenska, L | 1 |
| Kirov, R | 2 |
| Csaba, Z | 1 |
| Csernus, V | 1 |
| Gerendai, I | 1 |
| Teng, GQ | 1 |
| Williams, J | 1 |
| Zhang, L | 1 |
| Purdy, R | 1 |
| Pearce, WJ | 1 |
| Meltzer, CC | 1 |
| Smith, G | 1 |
| Price, JC | 1 |
| Reynolds, CF | 1 |
| Mathis, CA | 1 |
| Greer, P | 1 |
| Lopresti, B | 1 |
| Mintun, MA | 1 |
| Pollock, BG | 1 |
| Ben-Eliezer, D | 1 |
| Cantwell, MN | 1 |
| Kaye, W | 1 |
| DeKosky, ST | 1 |
| Ferrari, PF | 1 |
| Lowther, S | 1 |
| Tidbury, H | 1 |
| Greengrass, P | 1 |
| Wilson, CA | 1 |
| Horton, RW | 1 |
| Onodera, T | 1 |
| Watanabe, R | 1 |
| Tha, KK | 1 |
| Hayashi, Y | 1 |
| Murayama, T | 1 |
| Okuma, Y | 1 |
| Ono, C | 1 |
| Oketani, Y | 1 |
| Hosokawa, M | 1 |
| Nomura, Y | 1 |
| Andorn, AC | 1 |
| Pappolla, MA | 1 |
| Larisch, R | 1 |
| Klimke, A | 1 |
| Mayoral, F | 1 |
| Hamacher, K | 1 |
| Herzog, HR | 1 |
| Vosberg, H | 1 |
| Tosch, M | 1 |
| Gaebel, W | 1 |
| Rivas, F | 1 |
| Coenen, HH | 1 |
| Müller-Gärtner, HW | 1 |
| Thomas, CV | 1 |
| Mellick, JR | 1 |
| Khan, IA | 1 |
| Thomas, P | 1 |
| Suhara, T | 1 |
| Nakayama, K | 1 |
| Inoue, O | 1 |
| Fukuda, H | 2 |
| Shimizu, M | 1 |
| Mori, A | 1 |
| Tateno, Y | 1 |
| Persson, B | 1 |
| Heykants, J | 1 |
| Hedner, T | 1 |
| Amstein, R | 1 |
| Fetkovska, N | 1 |
| Bühler, FR | 1 |
| Michela, VL | 1 |
| Stratton, SE | 1 |
| Lorden, JF | 1 |
| Gould, SE | 1 |
| Silas, JH | 1 |
| Hosie, J | 1 |
| Gross-Isseroff, R | 1 |
| Salama, D | 1 |
| Israeli, M | 1 |
| Biegon, A | 1 |
| De Crée, J | 1 |
| Hoing, M | 1 |
| De Ryck, M | 1 |
| Symoens, J | 1 |
| Brunello, N | 1 |
| Riva, M | 1 |
| Rovescalli, AC | 1 |
| Galimberti, R | 1 |
| Racagni, G | 1 |
| Staessen, J | 1 |
| Fagard, R | 1 |
| Lijnen, P | 1 |
| Rorive, G | 1 |
| Amery, A | 1 |
| Doyle, AE | 1 |
| Blauw, GJ | 1 |
| van Brummelen, P | 1 |
| Chang, PC | 1 |
| Vermeij, P | 1 |
| van Zwieten, PA | 1 |
| Battaglia, G | 1 |
| Norman, AB | 1 |
| Creese, I | 1 |
| Breckenridge, A | 1 |
| Donnelly, R | 1 |
| Elliott, HL | 1 |
| Meredith, PA | 1 |
| Hughes, DM | 1 |
| Reid, JL | 1 |
| Egan, B | 1 |
| Conlon, ME | 1 |
| Campbell, R | 1 |
| Schork, N | 1 |
| Zwiefler, A | 1 |
| Julius, S | 1 |
| Moritoki, H | 1 |
| Iwamoto, T | 1 |
| Kanaya, J | 1 |
| Ishida, Y | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Kinetic Studies in Whole Body and Brain of [11C]DASB PET Imaging of Serotonin Transporters[NCT00059046] | 20 participants | Observational | 2003-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
3 reviews available for ketanserin and Aging
| Article | Year |
|---|---|
Clinical pharmacokinetics of ketanserin.
Topics: Aging; Drug Interactions; Humans; Ketanserin; Kidney Diseases; Liver Diseases | 1991 |
Why are the antihypertensive effects of ketanserin age-related?
Topics: Adult; Aged; Aging; Humans; Hypertension; Ketanserin; Middle Aged | 1988 |
Ageing, serotonin and ketanserin.
Topics: Adult; Aged; Aged, 80 and over; Aging; Humans; Hypertension; Ketanserin; Middle Aged; Serotonin | 1988 |
Trials
3 trials available for ketanserin and Aging
| Article | Year |
|---|---|
MR-based automatic delineation of volumes of interest in human brain PET images using probability maps.
Topics: Aged; Aged, 80 and over; Aging; Algorithms; Atrophy; Brain; Brain Mapping; Cognition Disorders; Fema | 2005 |
Double-blind comparison of ketanserin and propranolol in hypertensive patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Body Weight; Chromatography, High | 1988 |
Effects of ketanserin on blood pressure and platelet aggregation in elderly men with mild hypertension.
Topics: Adult; Aged; Aging; Angiotensin II; Blood Pressure; Calcium; Humans; Hypertension; Intracellular Mem | 1988 |
Other Studies
46 other studies available for ketanserin and Aging
| Article | Year |
|---|---|
5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Ketanserin; Muscle Contraction; Receptor, Serotoni | 2018 |
Effect of ageing on the passive and active tension and pharmacodynamic characteristics of rat coronary arteries: age-dependent increase in sensitivity to 5-HT and K+.
Topics: Aging; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Ketanseri | 2012 |
A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables.
Topics: Adult; Aged; Aging; Blood Proteins; Body Mass Index; Brain; Databases, Factual; Female; Fluorine Rad | 2004 |
Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides.
Topics: Aged; Aging; Alzheimer Disease; Binding, Competitive; Biogenic Amines; Brain; Choline O-Acetyltransf | 1984 |
Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.
Topics: Adolescent; Adult; Aged; Aging; Cerebral Cortex; Hippocampus; Humans; Ketanserin; Kinetics; Methyser | 1984 |
Haemorheological effects of ketanserin, a selective 5-HT2 receptor antagonist, in aged, spontaneously hypertensive dogs.
Topics: Aging; Animals; Blood Cell Count; Blood Pressure; Blood Viscosity; Dogs; Erythrocyte Membrane; Hyper | 1982 |
Detection and quantitation of 5-HT1A and 5-HT2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aging; Amino Acid Isomerases; Base Sequence; Binding | 1994 |
Age-related behavioural, neurochemical and radioligand binding changes in the central 5-HT system of Sprague-Dawley rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Behavior, Animal; Binding, Com | 1993 |
Involvement of serotonin in developmental plasticity of kitten visual cortex.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Cats; Functional Laterality; Ketanserin; | 1995 |
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding.
Topics: Aging; Animals; Autoradiography; Benzazepines; Brain Chemistry; Cerebral Cortex; Drugs, Chinese Herb | 1994 |
Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats.
Topics: Aging; Amphetamines; Animals; Biguanides; Blood Pressure; Heart Rate; Ketanserin; Male; Rats; Rats, | 1994 |
Binding sites for 5-hydroxytryptamine-2 receptor agonists are predominantly located in striosomes in the human basal ganglia.
Topics: Adult; Aged; Aging; Animals; Basal Ganglia; Binding Sites; Binding, Competitive; Brain; Cats; Cattle | 1994 |
Aging and vasoconstrictor responses mediated by alpha 2-adrenoceptors and 5-HT1 and 5-HT2 receptors.
Topics: Adult; Aged; Aging; Animals; Female; Humans; In Vitro Techniques; Ketanserin; Male; Methiothepin; Mi | 1994 |
Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Cyproheptadine; Ergolines; Ketanserin; Metam | 1994 |
Modulation of serotonin binding sites in the brain of the Djungarian hamster, Phodopus sungorus, during adaptation to a short photoperiod.
Topics: Adaptation, Physiological; Aging; Animals; Body Weight; Brain Chemistry; Cerebral Cortex; Cholestero | 1993 |
Effect of aging in human cortical pre- and postsynaptic serotonin binding sites.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Aging; Binding Sites; Female; Front | 1993 |
Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Blood-Br | 1995 |
Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aging; Autoradiography; Humans; Ket | 1996 |
Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aging; Angiotensin II; Animals; Ant | 1996 |
Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging.
Topics: Adult; Aging; Brain; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Female; Fluorine Radioisot | 1996 |
Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats.
Topics: Aging; Amphetamines; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electroenc | 1997 |
High-voltage electroencephalogram spindles in rats, aging and 5-HT2 antagonism.
Topics: Aging; Alpha Rhythm; Animals; Cyproheptadine; Electroencephalography; Ketanserin; Male; Rats; Rats, | 1998 |
Age-dependent effect of ketanserin on the sleep-waking phases in rats.
Topics: Aging; Animals; Electroencephalography; Ketanserin; Male; Polysomnography; Rats; Rats, Wistar; Serot | 1998 |
Intratesticular serotonin affects steroidogenesis in the rat testis.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Ketanserin; Male; Orchiectomy; Rats; Rats, Sprague-Dawley; | 1998 |
Does chronic ketanserin treatment enhance bradycardia in old rats by serotonergic blockade?
Topics: Adrenergic alpha-Agonists; Aging; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bra | 1998 |
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; F | 1998 |
Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction.
Topics: Adolescent; Adult; Aged; Aging; Brain; Female; Fluorine Radioisotopes; Humans; Ketanserin; Male; Mid | 1998 |
The influence of gender and age on neonatal rat hypothalamic 5-HT1A and 5-HT2A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amygdala; Animals; Animals, Newborn; Female; Gene Exp | 1999 |
Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Benzazepines; Brain; Depre | 2000 |
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catec | 2001 |
Disturbance of serotonin 5HT2 receptors in remitted patients suffering from hereditary depressive disorder.
Topics: Adult; Aged; Aging; Brain; Cerebral Cortex; Depressive Disorder; Female; Fluorine Radioisotopes; Hum | 2001 |
Ketanserin versus urapidil: age-related cardiovascular effects in conscious rats.
Topics: Aging; Angiotensins; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Keta | 2002 |
Stimulatory effects of serotonin on maturational gonadotropin release in the Atlantic croaker, Micropogonias undulatus.
Topics: Aging; Animals; Female; Fluoxetine; Gonadotropin-Releasing Hormone; Gonadotropins; In Vitro Techniqu | 1992 |
D1 dopamine receptor binding in mood disorders measured by positron emission tomography.
Topics: Adult; Aged; Aging; Animals; Benzazepines; Bipolar Disorder; Cerebral Cortex; Humans; Ketanserin; Ma | 1992 |
Ageing is associated with increased 5-HT2-receptor affinity and decreased receptor reserve in rat isolated coronary arteries.
Topics: Aging; Animals; Coronary Vessels; In Vitro Techniques; Ketanserin; Kinetics; Male; Muscle Contractio | 1991 |
Age, platelet serotonin kinetics and 5HT2-receptor blockade in essential hypertension.
Topics: Adult; Aged; Aging; Blood Platelets; Humans; Hypertension; Ketanserin; Kinetics; Middle Aged; Recept | 1990 |
Enhanced sensitivity to quipazine in the genetically dystonic rat (dt).
Topics: Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Ketanserin; Phen | 1990 |
Could the increased antihypertensive efficacy of ketanserin in the elderly be due to altered pharmacokinetics?
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Hypertension; Ketanserin; Male; Middle Aged | 1990 |
Autoradiographic analysis of age-dependent changes in serotonin 5-HT2 receptors of the human brain postmortem.
Topics: Adult; Aged; Aging; Autopsy; Autoradiography; Brain; Humans; Ketanserin; Kinetics; Middle Aged; Orga | 1990 |
The acute antihypertensive effect of ketanserin increases with age.
Topics: Adult; Aged; Aging; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Injection | 1985 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami | 1988 |
Arterial and venous effects of serotonin in the forearm of healthy subjects are not age-related.
Topics: Adult; Aged; Aging; Blood Pressure; Forearm; Heart Rate; Humans; Ketanserin; Male; Methoxamine; Midd | 1989 |
Differential serotonin2 receptor recovery in mature and senescent rat brain after irreversible receptor modification: effect of chronic reserpine treatment.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Brain; GTP-Binding Proteins; Guanylyl Imidodiphosphate | 1987 |
Ketanserin concentration-effect relationships in individual hypertensive patients.
Topics: Aging; Female; Hemodynamics; Humans; Hypertension; Ketanserin; Male; Middle Aged | 1988 |
Abstracts of the symposium on hypertension and the ageing cardiovascular system: the role of serotonin. Brussels, February 7, 1987.
Topics: Aging; Cardiovascular Physiological Phenomena; Humans; Hypertension; Ketanserin; Serotonin | 1987 |
Age-related change in serotonin-mediated prejunctional inhibition of rat vas deferens.
Topics: Adenosine Triphosphate; Aging; Animals; Drug Synergism; Electric Stimulation; In Vitro Techniques; K | 1986 |