Page last updated: 2024-10-29

ketanserin and Aging

ketanserin has been researched along with Aging in 52 studies

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Thirteen men, age 60 +/- 2 years (mean +/- SEM) with mild hypertension, 151 +/- 4/95 +/- 3 mm Hg, completed a randomized, double-blind, placebo-controlled crossover trial of ketanserin therapy."9.06Effects of ketanserin on blood pressure and platelet aggregation in elderly men with mild hypertension. ( Campbell, R; Conlon, ME; Egan, B; Julius, S; Schork, N; Zwiefler, A, 1988)
"To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats."7.69Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996)
"Treatment with ketanserin caused hypotension, enhanced bradycardia, attenuated reflex tachycardia, and reversed serotonin (5-HT) responses, with all effects being more pronounced in 24-month-old rats than in younger rats."5.30Does chronic ketanserin treatment enhance bradycardia in old rats by serotonergic blockade? ( Buñag, RD; Davidow, LW, 1998)
"Ketanserin treatment lowered blood pressure consistently, and the ensuing hypotension was more pronounced in 14- and 24-month than in 4-month-old rats."5.29Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. ( Buñag, RD; Davidow, LW; Schmitz, TM, 1994)
"Thirteen men, age 60 +/- 2 years (mean +/- SEM) with mild hypertension, 151 +/- 4/95 +/- 3 mm Hg, completed a randomized, double-blind, placebo-controlled crossover trial of ketanserin therapy."5.06Effects of ketanserin on blood pressure and platelet aggregation in elderly men with mild hypertension. ( Campbell, R; Conlon, ME; Egan, B; Julius, S; Schork, N; Zwiefler, A, 1988)
" Thirty men and twenty-two women aged between 21 and 79 years were investigated with magnetic resonance imaging (MRI) and [(18)F]-altanserin positron emission tomography (PET)."3.72A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables. ( Adams, KH; Frøkjaer, V; Hasselbalch, SG; Haugbøl, S; Holm, S; Knudsen, GM; Madsen, K; Martiny, L; Paulson, OB; Pinborg, LH; Svarer, C, 2004)
"To determine whether cardiovascular effects of ketanserin are altered differently with aging as compared with those of prazosin, we recorded blood pressure (BP) and heart rate (HR) changes produced by treatment with either drug in three age groups of conscious Sprague-Dawley rats."3.69Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats. ( Buñag, RD; Davidow, LW, 1996)
" Furthermore, aging does not seem to be associated with a reduced cortical serotonergic innervation, as indicated by the stability of the [3H]paroxetine-labeled 5-HT uptake sites."3.68Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. ( Arranz, B; Eriksson, A; Marcusson, J; Mellerup, E; Plenge, P, 1993)
"Both normal and genetically dystonic (dt) rats show a high-frequency forepaw tremor in response to systemic administration of the serotonin (5-HT) agonist quipazine at 8 days of age."3.68Enhanced sensitivity to quipazine in the genetically dystonic rat (dt). ( Lorden, JF; Michela, VL; Stratton, SE, 1990)
"Ketanserin is a serotonin S2-receptor antagonist introduced for the treatment of arterial hypertension and vasospastic disorders."2.38Clinical pharmacokinetics of ketanserin. ( Hedner, T; Heykants, J; Persson, B, 1991)
"The influence of ageing on the passive and active tension and pharmacodynamic characteristics of intramural coronary arteries from 3-month-old and 2-year-old male Wistar rats was investigated using an isometric myograph."1.38Effect of ageing on the passive and active tension and pharmacodynamic characteristics of rat coronary arteries: age-dependent increase in sensitivity to 5-HT and K+. ( Boonen, HC; Nyborg, NC; Outzen, EM; Sheykhzade, M; Simonsen, AH, 2012)
"Treatment with ketanserin caused hypotension, enhanced bradycardia, attenuated reflex tachycardia, and reversed serotonin (5-HT) responses, with all effects being more pronounced in 24-month-old rats than in younger rats."1.30Does chronic ketanserin treatment enhance bradycardia in old rats by serotonergic blockade? ( Buñag, RD; Davidow, LW, 1998)
" Long-term administration of KKT resulted in decreases in [3H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [3H]ketanserine binding to the caudate/putamen in young rats."1.29Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding. ( Hasegawa, T; Hayashi, T; Ishihara, S; Kameyama, T; Kaneyuki, T; Morimasa, T; Nabeshima, T; Shohmori, T; Yamada, K, 1994)
"Ketanserin treatment lowered blood pressure consistently, and the ensuing hypotension was more pronounced in 14- and 24-month than in 4-month-old rats."1.29Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. ( Buñag, RD; Davidow, LW; Schmitz, TM, 1994)
"Ten patients with bipolar mood disorders and 21 normal controls were studied in the drug-free state."1.28D1 dopamine receptor binding in mood disorders measured by positron emission tomography. ( Fukuda, H; Inoue, O; Mori, A; Nakayama, K; Shimizu, M; Suhara, T; Tateno, Y, 1992)
"Ketanserin is a serotonin S2-receptor antagonist that is an effective antihypertensive agent with a greater blood pressure reduction in older patients."1.28Could the increased antihypertensive efficacy of ketanserin in the elderly be due to altered pharmacokinetics? ( Gould, SE; Hosie, J; Silas, JH, 1990)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199014 (26.92)18.7374
1990's30 (57.69)18.2507
2000's6 (11.54)29.6817
2010's2 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lim, I1
Chess-Williams, R1
Sellers, D1
Sheykhzade, M1
Simonsen, AH1
Boonen, HC1
Outzen, EM1
Nyborg, NC2
Adams, KH1
Pinborg, LH2
Svarer, C2
Hasselbalch, SG2
Holm, S2
Haugbøl, S2
Madsen, K2
Frøkjaer, V1
Martiny, L1
Paulson, OB2
Knudsen, GM2
Frøkjaer, VG1
Crow, TJ1
Cross, AJ1
Cooper, SJ1
Deakin, JF1
Ferrier, IN1
Johnson, JA1
Joseph, MH1
Owen, F1
Poulter, M1
Lofthouse, R1
Marcusson, JO1
Morgan, DG1
Winblad, B1
Finch, CE1
De Clerck, F1
Jageneau, A1
Dom, J1
Burnet, PW1
Eastwood, SL1
Harrison, PJ1
Robson, L1
Gower, AJ1
Kendall, DA1
Marsden, CA1
Gu, Q1
Singer, W1
Ishihara, S1
Yamada, K1
Hayashi, T1
Hasegawa, T1
Kameyama, T1
Morimasa, T1
Kaneyuki, T1
Shohmori, T1
Nabeshima, T1
Davidow, LW3
Schmitz, TM1
Buñag, RD4
Waeber, C1
Palacios, JM1
Docherty, JR1
Wedderburn, JF1
Sillar, KT1
Kaminski, D1
Weiner, N1
Sturm, G1
Wesemann, W1
Arranz, B1
Eriksson, A1
Mellerup, E1
Plenge, P1
Marcusson, J1
Sharma, HS1
Westman, J1
Navarro, JC1
Dey, PK1
Nyberg, F1
Laporte, AM1
Doyen, C1
Nevo, IT1
Chauveau, J1
Hauw, JJ1
Hamon, M1
Rosier, A1
Dupont, P1
Peuskens, J1
Bormans, G1
Vandenberghe, R1
Maes, M1
de Groot, T1
Schiepers, C1
Verbruggen, A1
Mortelmans, L1
Jäkälä, P1
Riekkinen, P1
Moyanova, S2
Kortenska, L1
Kirov, R2
Csaba, Z1
Csernus, V1
Gerendai, I1
Teng, GQ1
Williams, J1
Zhang, L1
Purdy, R1
Pearce, WJ1
Meltzer, CC1
Smith, G1
Price, JC1
Reynolds, CF1
Mathis, CA1
Greer, P1
Lopresti, B1
Mintun, MA1
Pollock, BG1
Ben-Eliezer, D1
Cantwell, MN1
Kaye, W1
DeKosky, ST1
Ferrari, PF1
Lowther, S1
Tidbury, H1
Greengrass, P1
Wilson, CA1
Horton, RW1
Onodera, T1
Watanabe, R1
Tha, KK1
Hayashi, Y1
Murayama, T1
Okuma, Y1
Ono, C1
Oketani, Y1
Hosokawa, M1
Nomura, Y1
Andorn, AC1
Pappolla, MA1
Larisch, R1
Klimke, A1
Mayoral, F1
Hamacher, K1
Herzog, HR1
Vosberg, H1
Tosch, M1
Gaebel, W1
Rivas, F1
Coenen, HH1
Müller-Gärtner, HW1
Thomas, CV1
Mellick, JR1
Khan, IA1
Thomas, P1
Suhara, T1
Nakayama, K1
Inoue, O1
Fukuda, H2
Shimizu, M1
Mori, A1
Tateno, Y1
Persson, B1
Heykants, J1
Hedner, T1
Amstein, R1
Fetkovska, N1
Bühler, FR1
Michela, VL1
Stratton, SE1
Lorden, JF1
Gould, SE1
Silas, JH1
Hosie, J1
Gross-Isseroff, R1
Salama, D1
Israeli, M1
Biegon, A1
De Crée, J1
Hoing, M1
De Ryck, M1
Symoens, J1
Brunello, N1
Riva, M1
Rovescalli, AC1
Galimberti, R1
Racagni, G1
Staessen, J1
Fagard, R1
Lijnen, P1
Rorive, G1
Amery, A1
Doyle, AE1
Blauw, GJ1
van Brummelen, P1
Chang, PC1
Vermeij, P1
van Zwieten, PA1
Battaglia, G1
Norman, AB1
Creese, I1
Breckenridge, A1
Donnelly, R1
Elliott, HL1
Meredith, PA1
Hughes, DM1
Reid, JL1
Egan, B1
Conlon, ME1
Campbell, R1
Schork, N1
Zwiefler, A1
Julius, S1
Moritoki, H1
Iwamoto, T1
Kanaya, J1
Ishida, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Kinetic Studies in Whole Body and Brain of [11C]DASB PET Imaging of Serotonin Transporters[NCT00059046]20 participants Observational2003-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for ketanserin and Aging

ArticleYear
Clinical pharmacokinetics of ketanserin.
    Clinical pharmacokinetics, 1991, Volume: 20, Issue:4

    Topics: Aging; Drug Interactions; Humans; Ketanserin; Kidney Diseases; Liver Diseases

1991
Why are the antihypertensive effects of ketanserin age-related?
    Journal of cardiovascular pharmacology, 1988, Volume: 12 Suppl 8

    Topics: Adult; Aged; Aging; Humans; Hypertension; Ketanserin; Middle Aged

1988
Ageing, serotonin and ketanserin.
    Drugs, 1988, Volume: 36 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Humans; Hypertension; Ketanserin; Middle Aged; Serotonin

1988

Trials

3 trials available for ketanserin and Aging

ArticleYear
MR-based automatic delineation of volumes of interest in human brain PET images using probability maps.
    NeuroImage, 2005, Feb-15, Volume: 24, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Algorithms; Atrophy; Brain; Brain Mapping; Cognition Disorders; Fema

2005
Double-blind comparison of ketanserin and propranolol in hypertensive patients.
    Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Body Weight; Chromatography, High

1988
Effects of ketanserin on blood pressure and platelet aggregation in elderly men with mild hypertension.
    American journal of hypertension, 1988, Volume: 1, Issue:3 Pt 3

    Topics: Adult; Aged; Aging; Angiotensin II; Blood Pressure; Calcium; Humans; Hypertension; Intracellular Mem

1988

Other Studies

46 other studies available for ketanserin and Aging

ArticleYear
5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals.
    European journal of pharmacology, 2018, Jan-05, Volume: 818

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Ketanserin; Muscle Contraction; Receptor, Serotoni

2018
Effect of ageing on the passive and active tension and pharmacodynamic characteristics of rat coronary arteries: age-dependent increase in sensitivity to 5-HT and K+.
    Pharmacology, 2012, Volume: 90, Issue:3-4

    Topics: Aging; Animals; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Ketanseri

2012
A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables.
    NeuroImage, 2004, Volume: 21, Issue:3

    Topics: Adult; Aged; Aging; Blood Proteins; Body Mass Index; Brain; Databases, Factual; Female; Fluorine Rad

2004
Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides.
    Neuropharmacology, 1984, Volume: 23, Issue:12B

    Topics: Aged; Aging; Alzheimer Disease; Binding, Competitive; Biogenic Amines; Brain; Choline O-Acetyltransf

1984
Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age.
    Brain research, 1984, Oct-08, Volume: 311, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Cerebral Cortex; Hippocampus; Humans; Ketanserin; Kinetics; Methyser

1984
Haemorheological effects of ketanserin, a selective 5-HT2 receptor antagonist, in aged, spontaneously hypertensive dogs.
    Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 258, Issue:1

    Topics: Aging; Animals; Blood Cell Count; Blood Pressure; Blood Viscosity; Dogs; Erythrocyte Membrane; Hyper

1982
Detection and quantitation of 5-HT1A and 5-HT2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age.
    Neuroscience letters, 1994, Aug-29, Volume: 178, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aging; Amino Acid Isomerases; Base Sequence; Binding

1994
Age-related behavioural, neurochemical and radioligand binding changes in the central 5-HT system of Sprague-Dawley rats.
    Psychopharmacology, 1993, Volume: 113, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Behavior, Animal; Binding, Com

1993
Involvement of serotonin in developmental plasticity of kitten visual cortex.
    The European journal of neuroscience, 1995, Jun-01, Volume: 7, Issue:6

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Cats; Functional Laterality; Ketanserin;

1995
Effects of kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography: changes in dopamine D1 and serotonin 5-HT2A receptor binding.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:8

    Topics: Aging; Animals; Autoradiography; Benzazepines; Brain Chemistry; Cerebral Cortex; Drugs, Chinese Herb

1994
Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats.
    Aging (Milan, Italy), 1994, Volume: 6, Issue:4

    Topics: Aging; Amphetamines; Animals; Biguanides; Blood Pressure; Heart Rate; Ketanserin; Male; Rats; Rats,

1994
Binding sites for 5-hydroxytryptamine-2 receptor agonists are predominantly located in striosomes in the human basal ganglia.
    Brain research. Molecular brain research, 1994, Volume: 24, Issue:1-4

    Topics: Adult; Aged; Aging; Animals; Basal Ganglia; Binding Sites; Binding, Competitive; Brain; Cats; Cattle

1994
Aging and vasoconstrictor responses mediated by alpha 2-adrenoceptors and 5-HT1 and 5-HT2 receptors.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Adult; Aged; Aging; Animals; Female; Humans; In Vitro Techniques; Ketanserin; Male; Methiothepin; Mi

1994
Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors.
    Proceedings. Biological sciences, 1994, Jul-22, Volume: 257, Issue:1348

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Cyproheptadine; Ergolines; Ketanserin; Metam

1994
Modulation of serotonin binding sites in the brain of the Djungarian hamster, Phodopus sungorus, during adaptation to a short photoperiod.
    Journal of neural transmission. General section, 1993, Volume: 92, Issue:2-3

    Topics: Adaptation, Physiological; Aging; Animals; Body Weight; Brain Chemistry; Cerebral Cortex; Cholestero

1993
Effect of aging in human cortical pre- and postsynaptic serotonin binding sites.
    Brain research, 1993, Aug-20, Volume: 620, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Aging; Binding Sites; Female; Front

1993
Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat.
    Behavioural brain research, 1995, Dec-14, Volume: 72, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Blood-Br

1995
Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord.
    Journal of chemical neuroanatomy, 1996, Volume: 11, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aging; Autoradiography; Humans; Ket

1996
Hypotensive and reflex bradycardic effects of ketanserin, but not of prazosin, enhanced selectively in aging conscious rats.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aging; Angiotensin II; Animals; Ant

1996
Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging.
    Psychiatry research, 1996, Nov-25, Volume: 68, Issue:1

    Topics: Adult; Aging; Brain; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Female; Fluorine Radioisot

1996
Combined cholinergic and 5-HT2 receptor activation suppresses thalamocortical oscillations in aged rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:4

    Topics: Aging; Amphetamines; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Drug Synergism; Electroenc

1997
High-voltage electroencephalogram spindles in rats, aging and 5-HT2 antagonism.
    Brain research, 1998, Mar-09, Volume: 786, Issue:1-2

    Topics: Aging; Alpha Rhythm; Animals; Cyproheptadine; Electroencephalography; Ketanserin; Male; Rats; Rats,

1998
Age-dependent effect of ketanserin on the sleep-waking phases in rats.
    The International journal of neuroscience, 1998, Volume: 93, Issue:3-4

    Topics: Aging; Animals; Electroencephalography; Ketanserin; Male; Polysomnography; Rats; Rats, Wistar; Serot

1998
Intratesticular serotonin affects steroidogenesis in the rat testis.
    Journal of neuroendocrinology, 1998, Volume: 10, Issue:5

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Ketanserin; Male; Orchiectomy; Rats; Rats, Sprague-Dawley;

1998
Does chronic ketanserin treatment enhance bradycardia in old rats by serotonergic blockade?
    Aging (Milan, Italy), 1998, Volume: 10, Issue:2

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bra

1998
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; F

1998
Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction.
    Brain research, 1998, Nov-30, Volume: 813, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Brain; Female; Fluorine Radioisotopes; Humans; Ketanserin; Male; Mid

1998
The influence of gender and age on neonatal rat hypothalamic 5-HT1A and 5-HT2A receptors.
    Cellular and molecular neurobiology, 1999, Volume: 19, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amygdala; Animals; Animals, Newborn; Female; Gene Exp

1999
Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10.
    Japanese journal of pharmacology, 2000, Volume: 83, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Benzazepines; Brain; Depre

2000
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
    Free radical biology & medicine, 2001, Aug-01, Volume: 31, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catec

2001
Disturbance of serotonin 5HT2 receptors in remitted patients suffering from hereditary depressive disorder.
    Nuklearmedizin. Nuclear medicine, 2001, Volume: 40, Issue:4

    Topics: Adult; Aged; Aging; Brain; Cerebral Cortex; Depressive Disorder; Female; Fluorine Radioisotopes; Hum

2001
Ketanserin versus urapidil: age-related cardiovascular effects in conscious rats.
    European journal of pharmacology, 2002, Jan-18, Volume: 435, Issue:1

    Topics: Aging; Angiotensins; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Keta

2002
Stimulatory effects of serotonin on maturational gonadotropin release in the Atlantic croaker, Micropogonias undulatus.
    General and comparative endocrinology, 1992, Volume: 88, Issue:3

    Topics: Aging; Animals; Female; Fluoxetine; Gonadotropin-Releasing Hormone; Gonadotropins; In Vitro Techniqu

1992
D1 dopamine receptor binding in mood disorders measured by positron emission tomography.
    Psychopharmacology, 1992, Volume: 106, Issue:1

    Topics: Adult; Aged; Aging; Animals; Benzazepines; Bipolar Disorder; Cerebral Cortex; Humans; Ketanserin; Ma

1992
Ageing is associated with increased 5-HT2-receptor affinity and decreased receptor reserve in rat isolated coronary arteries.
    British journal of pharmacology, 1991, Volume: 102, Issue:1

    Topics: Aging; Animals; Coronary Vessels; In Vitro Techniques; Ketanserin; Kinetics; Male; Muscle Contractio

1991
Age, platelet serotonin kinetics and 5HT2-receptor blockade in essential hypertension.
    Journal of human hypertension, 1990, Volume: 4, Issue:4

    Topics: Adult; Aged; Aging; Blood Platelets; Humans; Hypertension; Ketanserin; Kinetics; Middle Aged; Recept

1990
Enhanced sensitivity to quipazine in the genetically dystonic rat (dt).
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:1

    Topics: Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Ketanserin; Phen

1990
Could the increased antihypertensive efficacy of ketanserin in the elderly be due to altered pharmacokinetics?
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Hypertension; Ketanserin; Male; Middle Aged

1990
Autoradiographic analysis of age-dependent changes in serotonin 5-HT2 receptors of the human brain postmortem.
    Brain research, 1990, Jun-11, Volume: 519, Issue:1-2

    Topics: Adult; Aged; Aging; Autopsy; Autoradiography; Brain; Humans; Ketanserin; Kinetics; Middle Aged; Orga

1990
The acute antihypertensive effect of ketanserin increases with age.
    Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 7

    Topics: Adult; Aged; Aging; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Injection

1985
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:3

    Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami

1988
Arterial and venous effects of serotonin in the forearm of healthy subjects are not age-related.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:1

    Topics: Adult; Aged; Aging; Blood Pressure; Forearm; Heart Rate; Humans; Ketanserin; Male; Methoxamine; Midd

1989
Differential serotonin2 receptor recovery in mature and senescent rat brain after irreversible receptor modification: effect of chronic reserpine treatment.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Brain; GTP-Binding Proteins; Guanylyl Imidodiphosphate

1987
Ketanserin concentration-effect relationships in individual hypertensive patients.
    British journal of clinical pharmacology, 1988, Volume: 26, Issue:1

    Topics: Aging; Female; Hemodynamics; Humans; Hypertension; Ketanserin; Male; Middle Aged

1988
Abstracts of the symposium on hypertension and the ageing cardiovascular system: the role of serotonin. Brussels, February 7, 1987.
    Acta cardiologica, 1987, Volume: 42, Issue:5

    Topics: Aging; Cardiovascular Physiological Phenomena; Humans; Hypertension; Ketanserin; Serotonin

1987
Age-related change in serotonin-mediated prejunctional inhibition of rat vas deferens.
    European journal of pharmacology, 1986, Dec-02, Volume: 132, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Drug Synergism; Electric Stimulation; In Vitro Techniques; K

1986