ketanserin has been researched along with Aggression in 16 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In suicide subjects, lifetime aggression scores correlated positively with [(3)H] ketanserin binding in all prefrontal Brodmann areas examined, after adjusting for age and sex." | 3.73 | Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide. ( Arango, V; Ellis, SP; Kassir, SA; Mann, JJ; Oquendo, MA; Russo, SA; Underwood, MD, 2006) |
| " There was no dose-response relationship with the agonist." | 1.33 | Maternal aggression in Wistar rats: effect of 5-HT2A/2C receptor agonist and antagonist microinjected into the dorsal periaqueductal gray matter and medial septum. ( da Silva, SP; de Almeida, RM; de Oliveira, VP; Giovenardi, M; Stein, DJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Juárez, P | 1 |
| Valdovinos, MG | 1 |
| May, ME | 1 |
| Lloyd, BP | 1 |
| Couppis, MH | 1 |
| Kennedy, CH | 1 |
| Soloff, PH | 3 |
| Chiappetta, L | 1 |
| Mason, NS | 2 |
| Becker, C | 2 |
| Price, JC | 3 |
| Johnson, O | 1 |
| Becnel, J | 1 |
| Nichols, CD | 1 |
| Meltzer, CC | 2 |
| da Cunha-Bang, S | 1 |
| Stenbæk, DS | 1 |
| Holst, K | 1 |
| Licht, CL | 1 |
| Jensen, PS | 1 |
| Frokjaer, VG | 1 |
| Mortensen, EL | 1 |
| Knudsen, GM | 1 |
| de Almeida, RM | 1 |
| Giovenardi, M | 1 |
| da Silva, SP | 1 |
| de Oliveira, VP | 1 |
| Stein, DJ | 1 |
| Oquendo, MA | 1 |
| Russo, SA | 1 |
| Underwood, MD | 1 |
| Kassir, SA | 1 |
| Ellis, SP | 1 |
| Mann, JJ | 1 |
| Arango, V | 1 |
| Fabio, A | 1 |
| Frank, GK | 1 |
| Kaye, WH | 1 |
| Blumensohn, R | 1 |
| Ratzoni, G | 1 |
| Weizman, A | 1 |
| Israeli, M | 1 |
| Greuner, N | 1 |
| Apter, A | 1 |
| Tyano, S | 1 |
| Biegon, A | 1 |
| Shih, JC | 2 |
| Ridd, MJ | 2 |
| Chen, K | 2 |
| Meehan, WP | 1 |
| Kung, MP | 1 |
| Seif, I | 2 |
| De Maeyer, E | 1 |
| Matto, V | 3 |
| Skrebuhhova, T | 1 |
| Allikmets, L | 3 |
| Skrebuhhova-Malmros, T | 1 |
| Pruus, K | 1 |
| Rudissaar, R | 1 |
| Vaarmann, A | 1 |
| Datla, KP | 1 |
| Mitra, SK | 1 |
| Bhattacharya, SK | 1 |
| Fachinelli, C | 1 |
| Sargo, S | 1 |
| Bataller, R | 1 |
| Rodríguez Echandía, EL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for ketanserin and Aggression
| Article | Year |
|---|---|
Serotonin₂A/C receptors mediate the aggressive phenotype of TLX gene knockout mice.
Topics: Aggression; Animals; Behavior, Animal; Clozapine; Ketanserin; Male; Mice; Mice, Knockout; Motor Acti | 2013 |
Effects of serotonin-2A receptor binding and gender on personality traits and suicidal behavior in borderline personality disorder.
Topics: Adult; Aggression; Borderline Personality Disorder; Contrast Media; Depression; Female; Fluorodeoxyg | 2014 |
Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amphetamines; Analysis of Variance; Animals; Dro | 2009 |
Gender, personality, and serotonin-2A receptor binding in healthy subjects.
Topics: Adolescent; Adult; Aggression; Brain; Brain Mapping; Female; Health Status; Humans; Impulsive Behavi | 2010 |
Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aggression; Female; Fluorodeoxyglucose F18; Frontal Lob | 2013 |
Maternal aggression in Wistar rats: effect of 5-HT2A/2C receptor agonist and antagonist microinjected into the dorsal periaqueductal gray matter and medial septum.
Topics: Aggression; Animals; Animals, Newborn; Female; Ketanserin; Male; Maternal Behavior; Microinjections; | 2005 |
Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aggression; Depressive Disorder, Major; Female; Humans; | 2006 |
5HT2A receptor binding is increased in borderline personality disorder.
Topics: Adult; Aggression; Borderline Personality Disorder; Brain; Child; Child Abuse; Depression; Female; F | 2007 |
Reduction in serotonin 5HT2 receptor binding on platelets of delinquent adolescents.
Topics: Adolescent; Age Distribution; Age Factors; Aggression; Binding, Competitive; Blood Platelets; Child; | 1995 |
Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A.
Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Brain; Corpus Striatum; Drug Evaluation, Preclini | 1999 |
Apomorphine-induced upregulation of serotonin 5-HT2A receptors in male rats is independent from development of aggressive behaviour.
Topics: Aggression; Animals; Apomorphine; Cerebral Cortex; Dopamine Agonists; Hippocampus; Hypothalamus; Ket | 1999 |
The serotonin 5-HT(2A) receptor subtype does not mediate apomorphine-induced aggressive behaviour in male Wistar rats.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antag | 2000 |
Ginkgo biloba abolishes aggression in mice lacking MAO A.
Topics: Aggression; Animals; Ginkgo biloba; Ketanserin; Male; Mice; Mice, Knockout; Monoamine Oxidase; Phyto | 2000 |
Apomorphine-induced aggressive behaviour in para-chlorophenylalanine-treated male rats: implications to brain.
Topics: Aggression; Animals; Apomorphine; Biogenic Monoamines; Brain; Brain Chemistry; Dopamine Agonists; Fe | 2001 |
Serotonergic modulation of footshock induced aggression in paired rats.
Topics: 5-Hydroxytryptophan; Aggression; Agonistic Behavior; Animals; Apomorphine; Citalopram; Clorgyline; D | 1991 |
Effect of 5-HTP and ketanserine on the aggressive reaction induced by food competition in dominant and submissive pigeons (Columba livia).
Topics: 5-Hydroxytryptophan; Aggression; Animals; Columbidae; Feeding Behavior; Ketanserin; Serotonin | 1989 |