keratan-sulfate and Spondylitis--Ankylosing

keratan-sulfate has been researched along with Spondylitis--Ankylosing* in 2 studies

Other Studies

2 other study(ies) available for keratan-sulfate and Spondylitis--Ankylosing

Article	Year
Keratan sulphate in rheumatoid arthritis, osteoarthritis, and inflammatory diseases. Annals of the rheumatic diseases, 1992, Volume: 51, Issue:10 Serum concentrations of antigenic keratan sulphate determined by an enzyme linked immunosorbent assay (ELISA) with a monoclonal antibody were studied in patients with rheumatoid arthritis (RA), osteoarthritis, ankylosing spondylitis, other inflammatory diseases, and a large control group of women without arthritis. Mean keratan sulphate concentrations were low in 117 women with RA compared with 227 female control subjects matched for age drawn from a community survey. There were significant correlations between serum keratan sulphate concentrations in patients with RA and serum C reactive protein and the erythrocyte sedimentation rate. Serum keratan sulphate concentrations were also low in 29 men and women with ankylosing spondylitis and 29 patients with arthritis and high concentrations of C reactive protein. In 98 women undergoing an operation for benign breast disease there were decreases in serum keratan sulphate concentrations after the operation which correlated with doses in serum C reactive protein. No differences were found in keratan sulphate concentrations in 137 women with osteoarthritis compared with controls. Within the group with osteoarthritis there were no differences for the various joint groups and there was no obvious correlation with radiographic severity or progression. These findings suggest serum keratan sulphate is unlikely to be useful as a diagnostic marker in osteoarthritis or RA but indicate a role for inflammation in the regulation of cartilage loss. Topics: Acute-Phase Reaction; Aged; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cartilage, Articular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Keratan Sulfate; Male; Middle Aged; Osteoarthritis; Rheumatic Diseases; Spondylitis, Ankylosing	1992
Serum keratan sulphate levels rise in rheumatoid arthritis patients, but fall in ankylosing spondylitis patients compared with normal controls. Biochemical Society transactions, 1990, Volume: 18, Issue:5 Serum levels of keratan sulphate (KS) were found to be significantly elevated in patients with destructive and predominantly seronegative rheumatoid arthritis (RA) compared with a control population. Levels in RA did not correlate with clinical or laboratory indices of joint activity or damage. Conversely levels were depressed in ankylosing spondylitis (AS) compared with controls. Topics: Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Humans; Keratan Sulfate; Reference Values; Spondylitis, Ankylosing	1990

Article

Year

Keratan sulphate in rheumatoid arthritis, osteoarthritis, and inflammatory diseases.

Annals of the rheumatic diseases, 1992, Volume: 51, Issue:10

Serum concentrations of antigenic keratan sulphate determined by an enzyme linked immunosorbent assay (ELISA) with a monoclonal antibody were studied in patients with rheumatoid arthritis (RA), osteoarthritis, ankylosing spondylitis, other inflammatory diseases, and a large control group of women without arthritis. Mean keratan sulphate concentrations were low in 117 women with RA compared with 227 female control subjects matched for age drawn from a community survey. There were significant correlations between serum keratan sulphate concentrations in patients with RA and serum C reactive protein and the erythrocyte sedimentation rate. Serum keratan sulphate concentrations were also low in 29 men and women with ankylosing spondylitis and 29 patients with arthritis and high concentrations of C reactive protein. In 98 women undergoing an operation for benign breast disease there were decreases in serum keratan sulphate concentrations after the operation which correlated with doses in serum C reactive protein. No differences were found in keratan sulphate concentrations in 137 women with osteoarthritis compared with controls. Within the group with osteoarthritis there were no differences for the various joint groups and there was no obvious correlation with radiographic severity or progression. These findings suggest serum keratan sulphate is unlikely to be useful as a diagnostic marker in osteoarthritis or RA but indicate a role for inflammation in the regulation of cartilage loss.

Topics: Acute-Phase Reaction; Aged; Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; C-Reactive Protein; Cartilage, Articular; Enzyme-Linked Immunosorbent Assay; Female; Humans; Keratan Sulfate; Male; Middle Aged; Osteoarthritis; Rheumatic Diseases; Spondylitis, Ankylosing

1992

Serum keratan sulphate levels rise in rheumatoid arthritis patients, but fall in ankylosing spondylitis patients compared with normal controls.

Biochemical Society transactions, 1990, Volume: 18, Issue:5

Serum levels of keratan sulphate (KS) were found to be significantly elevated in patients with destructive and predominantly seronegative rheumatoid arthritis (RA) compared with a control population. Levels in RA did not correlate with clinical or laboratory indices of joint activity or damage. Conversely levels were depressed in ankylosing spondylitis (AS) compared with controls.

Topics: Arthritis, Rheumatoid; Biomarkers; C-Reactive Protein; Humans; Keratan Sulfate; Reference Values; Spondylitis, Ankylosing

1990