keratan-sulfate and Mandibular-Neoplasms

Differential diagnosis of cementifying fibroma, ossifying fibroma and fibrous dysplasia by histological evaluation is often difficult. The aim of this study was to examine the immunoreactivities for keratan sulfate (KS) and chondroitin-4-sulfate (C4S) glycosaminoglycans of the histological samples obtained from mandibles of patients with these diseases.. The samples were collected from three patients with cementifying fibroma, two with ossifying fibroma and three with fibrous dysplasia and were subjected to immunohistochemical analyses.. The results demonstrated that a significant immunoreactivity for KS was found in lacunae housing cells in the cementum-particles of cementifying fibromas, while both ossifying fibromas and fibrous dysplasias showed no significant immunoreactivity for KS. For C4S, while the former showed little immunoreactivity, the latter two cases exhibited intensive immunostaining in the pre- and poorly mineralized matrices.. These results suggest that cementifying fibromas could be distinguished from these fibro-osseous tumors by using immunohistochemical analysis for KS and C4S.

Topics: Adolescent; Adult; Cementoma; Chondroitin Sulfates; Dental Cementum; Diagnosis, Differential; Female; Fibroma, Ossifying; Fibrous Dysplasia of Bone; Humans; Immunohistochemistry; Keratan Sulfate; Male; Mandibular Neoplasms; Odontogenic Tumors

Myxoma of the jaw is classified as an odontogenic tumor although final proof for an odontogenic origin is lacking. In the present study glycosaminoglycans (GAG's) in the extracellular matrix of a jaw myxoma were analyzed and compared with known data on GAG's in dental tissues. It was noted that the GAG's formed approximately 1% of the total tumor weight and 17% of the dry weight. Hyaluronic acid formed 72.4% of the GAG-fraction. Neither this high GAG-content nor the high fraction of hyaluronic acid are found in dental tissues and it is concluded that the myxoma matrix differs from the matrix in dental pulp and periodontal ligament.

Topics: Adult; Chondroitin Sulfates; Dermatan Sulfate; Extracellular Matrix; Female; Glycosaminoglycans; Humans; Hyaluronic Acid; Keratan Sulfate; Mandibular Neoplasms; Myxoma