kb-r7943 and Ischemic-Attack--Transient

kb-r7943 has been researched along with Ischemic-Attack--Transient* in 1 studies

Other Studies

1 other study(ies) available for kb-r7943 and Ischemic-Attack--Transient

Article	Year
KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. Neuroscience letters, 2014, Sep-19, Volume: 580 Remote areas connected to cortical infarcts, such as the thalamus, are affected by stroke due to delayed retrograde degeneration of afferent connections. This is temporally associated with the accumulation of β-amyloid (Aβ) and calcium. Here we tested a hypothesis that prevention of excessive Ca(2+) influx into the axoplasm via the reverse Na(+)/Ca(2+) exchanger (NCX) would provide axonal protection and eventually lessen the Aβ and calcium load in the thalamus. We found that chronic treatment with a specific inhibitor of the reverse NCX, KB-R7943 (30mg/kg once daily, 27 days) after middle cerebral artery occlusion did not prevent atypical secondary pathology in the thalamus or improve functional outcome. The present data do not support a role for reverse NCX activity in the complex pathology within the thalamus after cerebral ischemia. Topics: Amyloid beta-Peptides; Animals; Calcium; Ischemic Attack, Transient; Male; Motor Skills; Peptide Fragments; Rats, Wistar; Sodium-Calcium Exchanger; Thalamus; Thiourea	2014

Article

Year

KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats.

Neuroscience letters, 2014, Sep-19, Volume: 580

Remote areas connected to cortical infarcts, such as the thalamus, are affected by stroke due to delayed retrograde degeneration of afferent connections. This is temporally associated with the accumulation of β-amyloid (Aβ) and calcium. Here we tested a hypothesis that prevention of excessive Ca(2+) influx into the axoplasm via the reverse Na(+)/Ca(2+) exchanger (NCX) would provide axonal protection and eventually lessen the Aβ and calcium load in the thalamus. We found that chronic treatment with a specific inhibitor of the reverse NCX, KB-R7943 (30mg/kg once daily, 27 days) after middle cerebral artery occlusion did not prevent atypical secondary pathology in the thalamus or improve functional outcome. The present data do not support a role for reverse NCX activity in the complex pathology within the thalamus after cerebral ischemia.

Topics: Amyloid beta-Peptides; Animals; Calcium; Ischemic Attack, Transient; Male; Motor Skills; Peptide Fragments; Rats, Wistar; Sodium-Calcium Exchanger; Thalamus; Thiourea

2014