kavain has been researched along with Urinary-Bladder-Neoplasms* in 2 studies
2 other study(ies) available for kavain and Urinary-Bladder-Neoplasms
| Article | Year |
|---|---|
Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism.
UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g/kg) formulated food for approximately five months. Seventy-eight percent of the mice or more fed with kawain food survived more than six months of age, whereas only 32% control food-fed male mice survived, ( Topics: Animals; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Mice; Mice, Transgenic; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms | 2023 |
Kawain Inhibits Urinary Bladder Carcinogenesis through Epigenetic Inhibition of LSD1 and Upregulation of H3K4 Methylation.
Epidemiological evidence suggests that kava ( Topics: Animals; Carcinogenesis; Epigenesis, Genetic; Histone Demethylases; Humans; Lysine; Mice; Up-Regulation; Urinary Bladder; Urinary Bladder Neoplasms | 2023 |