kavain and Periodontal-Diseases

Six kava analogues of the structural type 3-oxocyclohex-1-en-1-yl benzoates (and corresponding benzamides) were synthesized and evaluated for their affect on periodontal deconstruction in collagen anti-body primed oral gavage model of periodontitis. The compounds were prepared through an acylation or amidation of the enolizable cyclic 1,3-diketone. We have learned that three of the analogues are responsible for the reduction of inflammatory cell counts within soft tissue. These novel kava-like molecules where the lactone is replaced by an α,β-unsaturated ketone show promise in the prevention and treatment of inflammation and alveolar bone loss associated with periodontitis.

Topics: Animals; Benzamides; Benzoates; Cyclohexanones; Kava; Macrophages; Mice; Periodontal Diseases; Porphyromonas gingivalis; Structure-Activity Relationship; Tumor Necrosis Factor-alpha