kavain and Carcinoma--Transitional-Cell

kavain has been researched along with Carcinoma--Transitional-Cell* in 1 studies

Other Studies

1 other study(ies) available for kavain and Carcinoma--Transitional-Cell

Article	Year
Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism. Molecules (Basel, Switzerland), 2023, Feb-09, Volume: 28, Issue:4 UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g/kg) formulated food for approximately five months. Seventy-eight percent of the mice or more fed with kawain food survived more than six months of age, whereas only 32% control food-fed male mice survived, ( Topics: Animals; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Mice; Mice, Transgenic; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms	2023

Article

Year

Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism.

Molecules (Basel, Switzerland), 2023, Feb-09, Volume: 28, Issue:4

UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g/kg) formulated food for approximately five months. Seventy-eight percent of the mice or more fed with kawain food survived more than six months of age, whereas only 32% control food-fed male mice survived, (

Topics: Animals; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Mice; Mice, Transgenic; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms

2023