karwinskia-toxin-t-514 and Pulmonary-Edema

Dimeric anthracenones obtained from the genus Karwinskia (Rhamnaceae) are characteristic compounds isolated from the plants of this species. Previous toxicity studies demonstrated Diast T-514 to be toxic to animals in experimental settings. Diast T-514 extracted and characterized from Karwinskia parvifolia, was studied in CD1 mice. The LD50 for this compound was determined. Animals were tested with Diast T-514 following enteral and parenteral administration. An LD50 dose by both oral and intraperitoneal administration showed selective damage to target organs.

Topics: Administration, Oral; Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Chemical and Drug Induced Liver Injury; Dimerization; Female; Injections, Intraperitoneal; Liver Diseases; Mice; Mice, Inbred Strains; Organ Specificity; Polymers; Pulmonary Edema