kaolinite has been researched along with Thyroid-Neoplasms* in 2 studies
2 other study(ies) available for kaolinite and Thyroid-Neoplasms
| Article | Year |
|---|---|
Nanoclay Drug-Delivery System Loading Potassium Iodide Promotes Endocytosis and Targeted Therapy in Anaplastic Thyroid Cancer.
The rapid proliferative biological behavior of primary foci of anaplastic thyroid cancer (ATC) makes it a lethal tumor. According to the specific iodine uptake capacity of thyroid cells and enhanced endocytosis of ATC cells, we designed a kind of nanoclay drug-loading system and showed a promising treatment strategy for ATC. Introducing potassium iodide (KI) improves the homoaggregation of clay nanoparticles and then affects the distribution of nanoparticles in vivo, which makes KI@DOX-Kaolin Topics: Drug Delivery Systems; Endocytosis; Humans; Kaolin; Potassium Iodide; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2023 |
Emerging integrated nanoclay-facilitated drug delivery system for papillary thyroid cancer therapy.
Nanoclay can be incorporated into emerging dual functional drug delivery systems (DDSs) to promote efficiency in drug delivery and reduce the toxicity of doxorubicin (DOX) used for thyroid cancer treatment. This paper reports the expansion of the basal spacing of kaolinite nanoclay was expanded from 0.72 nm to 0.85 nm, which could provide sufficiently spacious site for hosting doxorubicin molecules and controlling the diffusion rate. A targeted design for papillary thyroid cancer cells was achieved by introducing KI, which is consumed by the sodium-iodide symporter (NIS). As indicated by MTT assays, confocal laser scanning microscopy and bio-TEM observations, methoxy-intercalated kaolinite (KaolinMeOH) exhibited negligible cytotoxicity against papillary thyroid cancer cells. By contrast, DOX-KaolinMeOH showed dose-dependent therapeutic effects in vitro, and KI@DOX-KaolinMeOH was found to act as a powerful targeted therapeutic drug. Furthermore, active and passive targeting strategies played a role in the accumulation of the drug molecules, as verified by an in vivo bio-distribution analysis. Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Papillary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Doxorubicin; Drug Carriers; Drug Screening Assays, Antitumor; Female; Humans; Kaolin; Nanostructures; Rabbits; Swine; Swine, Miniature; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tissue Distribution | 2016 |