kaolinite and Foot-Diseases

kaolinite has been researched along with Foot-Diseases* in 3 studies

Other Studies

3 other study(ies) available for kaolinite and Foot-Diseases

ArticleYear
Marine bioactive compounds: stereospecific anti-inflammatory activity of natural and synthetic cordiachromene A.
    Journal of clinical pharmacology, 1992, Volume: 32, Issue:1

    A new synthesis is proposed for cordiachromene A (CCA), a bioactive component of the ascidian Aplidium antillense Gravier, using a method producing a racemic mixture. The anti-inflammatory activities of a natural extract and a chemically synthetic form of CCA were assessed in vivo by carrageenan-induced rat-paw edema. The activity of synthetic CCA was confirmed by a test on kaolin-induced granuloma in the rat. Strong activities were measured for both CCA, but comparison of results of the first test suggests that only the natural optically active isomer has an anti-inflammatory effect. CCA is similar to indomethacin in its effect on carrageenan-induced rat-paw edema and ten times as active as phenylbutazone.

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromones; Edema; Foot Diseases; Granuloma; Isomerism; Kaolin; Male; Mice; Rats

1992
Morphology of the bentonite and kaolin-induced rat-paw oedemas.
    International journal of tissue reactions, 1982, Volume: 4, Issue:2

    The bentonite and kaolin oedemas were simultaneously induced in the rat hind paws and their courses and morphological patterns were observed under the conditions of the same biological background. Gross examination has confirmed the former experience that the kaolin oedema has a more pronounced acute phase (maximum after five to seven hours) followed by subsequent spontaneous regression of the oedema, while the bentonite oedema has its acute phase less pronounced, attains its peak only on the second day, maintaining this same size over several weeks without substantial changes. The courses of the two oedemas were in correlation with the results of histological evaluation (oedematous exudation, polymorphonuclear and mononuclear infiltration and the phagocytic activity of the latter). Resorption of kaolin in the newly-developed non-specific granulation tissue was much faster than that of bentonite (after about three weeks, while bentonite was not resorbed even after six weeks). Further, pharmacological and histological examination was performed of the effects on the bentonite oedema of sodium salicylate and Prednisone during the first 24 hours. Both substances suppressed the oedema, sodium salicylate delayed both polymorphonuclear and mononuclear infiltration, Prednisone delayed only mononuclear infiltration. The presence of mononuclear population was confirmed also by means of the positive activity of non-specific esterase and the negative activity of alkaline phosphatase. The bentonite rat-paw oedema has thus been proved to be a suitable model of inflammatory reaction for testing anti-inflammatory drugs not only in short-term (acute) tests, but also in long-term ones, where it yields a uniform picture of non-specific foreign-body low-turnover granuloma.

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Bentonite; Edema; Female; Follow-Up Studies; Foot Diseases; Hindlimb; Inflammation; Kaolin; Male; Neutrophils; Phagocytes; Rats; Rats, Inbred Strains

1982
SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS IN RATS WITH 2-BUTOXYCARBONYLMETHYLENE-4-OXOTHIAZOLIDINE.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Binding Sites; Carrageenan; Foot Diseases; Formaldehyde; Freund's Adjuvant; Kaolin; Leukocyte Count; Pharmacology; Phenylbutazone; Rats; Research; Thiazoles; Toxicology; Tuberculin Test

1965