kaolinite and Abscess

1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carbamide (Chinoin 127), a non-narcotic analgesic with potent antiinflammatory activity is described. Chinoin-127 is more potent as an analgesic in the hot plate, Randall-Selitto and writhing tests than is acetylsalicylic acid (ASA) and an effective antiphlogistic agent in a battery of tests (carrageenin, kaolin and dextran induced rat paw edema, Northover test, carrageenin induced abscess, implanted cotton pellet method, adjuvant arthritis) used for measuring antiinflammatory activity. The PG-synthesis inhibitors (indometacin, suprofen) were found to be devoid of analgesic activity, and great test-dependent variations in their antiinflammatory effect were observed. They proved to be inactive in the Northover test. Unusual grade of inhibition in the carrageenin-induced rat paw edema test was obtainable by the simultaneous administration of Chinoin 127 and indometacin.

Topics: Abscess; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capillary Permeability; Carrageenan; Dextrans; Edema; Female; Granuloma; Kaolin; Male; Mice; Prostaglandins; Pyrimidinones; Rats; Stomach Ulcer

Topics: Abscess; Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Edema; Female; Formaldehyde; Gossypium; Granuloma; Inflammation; Irritants; Kaolin; Male; Models, Theoretical; Mononuclear Phagocyte System; Parabiosis; Rats; Saccharomyces; Thorium Dioxide; Zymosan

Topics: Abscess; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Croton Oil; Formaldehyde; Hydrocortisone; Indomethacin; Irritants; Kaolin; Mefenamic Acid; ortho-Aminobenzoates; Phenylbutazone; Rats