kamebakaurin has been researched along with Leukemia-P388* in 1 studies
1 other study(ies) available for kamebakaurin and Leukemia-P388
| Article | Year |
|---|---|
Excisanin H, a novel cytotoxic 14,20-epoxy-ent-kaurene diterpenoid, and three new ent-kaurene diterpenoids from Rabdosia excisa.
A novel 14,20-epoxy-ent-kaurene diterpenoid, excisanin H (1), and three new ent-kaurene diterpenoids, 2-4, were isolated from aerial parts of Rabdosia excisa along with eight known ent-kaurene diterpenoids, 5-12. The structural elucidations were made using spectral (HREIMS, IR, (1)H, (13)C, and 2D NMR) methods. The absolute configuration of 1 was determined by demonstrating that oxidation of kamebakaurin (8) produced excisanin H (1). These ent-kaurene diterpenoids all showed significant cytotoxic activity against P388 murine leukemia cells. Topics: Animals; Antineoplastic Agents, Phytogenic; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Lamiaceae; Leukemia P388; Molecular Structure; Oxidation-Reduction; Plants, Medicinal | 2004 |