kaliotoxin has been researched along with Epilepsy* in 1 studies
1 other study(ies) available for kaliotoxin and Epilepsy
| Article | Year |
|---|---|
Immunomodulatory and protective effects of interleukin-4 on the neuropathological alterations induced by a potassium channel blocker.
The pathophysiology of neurological diseases related to potassium-channel dysfunction such as epilepsy is increasingly linked to immune system modulation. However, there are limited reports of which interleukin-4 (IL-4) can act on the neuroinflammatory response after seizure. Hence, we evaluated the effect of IL-4 in murine model of neuroexcitotoxcity using kaliotoxin (KTx), a potassium-channel blocker. Results showed that IL-4 treatment can significantly reduce the neuronal death induced by KTx. Probably by decreasing mitochondria swelling, reversing oxidative damage and enhancing Bcl-2 expression. Furthermore, IL-4 treatment significantly reduced TNF-α expression and enhanced GFAP and IL-10 expressions in the brain. IL-4 can be neuroprotective in epileptogenesis. Topics: Animals; Cerebral Cortex; Epilepsy; Immunologic Factors; Injections, Intraperitoneal; Injections, Intraventricular; Interleukin-4; Mice; Neuroprotective Agents; Potassium Channel Blockers; Scorpion Venoms | 2021 |