kakkalide and Liver-Diseases--Alcoholic

Kakkalide, one of the major isoflavonoid components of Puerariae flos, has been investigated for its effect on ethanol-induced intoxication and on hepatic injury, including hyperglycaemia, in mice. Kakkalide reduced mortality associated with administration of ethanol. At doses of 100 and 200 mg kg-1 the effect of kakkalide was significant. The same dose of kakkalide prevented increased serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activity. At a dose of 200 mg kg-1 it also counteracted ethanol-induced elevation of glucose levels. These results suggest that kakkalide might be useful for counteracting the effects of alcohol and might be effective for treating hepatic injury.

Topics: Acute Disease; Animals; Disaccharides; Ethanol; Glycosides; Hyperglycemia; Isoflavones; Liver Diseases, Alcoholic; Male; Mice; Mice, Inbred Strains; Plant Extracts; Plants, Medicinal