kakkalide and Gastritis

kakkalide has been researched along with Gastritis* in 1 studies

Other Studies

1 other study(ies) available for kakkalide and Gastritis

ArticleYear
Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:2

    This study was designed to determine whether irisolidone and its glycoside kakkalide, which are the major constituents of the flower of Pueraria lobata (Kudzu) can attenuate ethanol-induced gastritic injury in mice.. Irisolidone and kakkalide inhibited IL-8 secretion and NF-κB activation in lipopolysaccharide-stimulated KATO III cells. Therefore, we investigated their protective effects against ethanol-induced gastric injury in mice. Pretreatment with kakkalide or irisolidone decreased the area of hemorrhagic ulcerative lesions caused by ethanol and suppressed stomach myeloperoxidase activity, CXCL4 secretion, and NF-κB activation. The ameliorating effect of irisolidone was more potent than that of kakkalide.. Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion.

    Topics: Animals; Cell Line; Ethanol; Flavonoids; Gastritis; Glycosides; Interleukin-8; Isoflavones; Lipopolysaccharides; Male; Mice, Inbred ICR; Neutrophils; NF-kappa B; Peroxidase; Platelet Factor 4; Protective Agents; Tumor Necrosis Factor-alpha

2017