kainic acid has been researched along with Seizures in 1571 studies
*Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 161 (10.25) | 18.7374 |
| 1990's | 401 (25.53) | 18.2507 |
| 2000's | 460 (29.28) | 29.6817 |
| 2010's | 419 (26.67) | 24.3611 |
| 2020's | 130 (8.27) | 2.80 |
| Authors | Studies |
|---|---|
| Bräuner-Osborne, H; Conti, P; De Amici, M; De Micheli, C; De Sarro, G; Madsen, U; Stensbøl, TB | 1 |
| Boutou, A; Denis, MC; Fischer, R; Iliopoulou, L; Kambas, K; Karamita, M; Kollias, G; Kontermann, RE; Lassmann, H; Papazian, I; Probert, L; Tsoukala, E | 1 |
| Artis, D; Chen, F; Chung, H; Habibi, E; Magee, EM; Parkhurst, CN; Phillips, D; Regev, A; Waldman, J; Yeung, BZ | 1 |
| Barker-Haliski, M; Knox, KM; White, HS; Zierath, DK | 1 |
| Barthet, G; Gorlewicz, A; Griguoli, M; Grosjean, N; Mulle, C; Vincent, P; Wilczynski, G; Zucca, S | 1 |
| Castellano, D; Lu, W; Tian, Q; Wu, K | 1 |
| Abdel Rassoul, R; Al-Koussa, H; Almardini, M; Alturk, S; Asdikian, JP; Asdikian, R; Hajjar, H; Issa, F; Jaafar, F; Mrad, Y; Nourelddine, F; Obeid, M; Salah, H | 1 |
| Drysdale, ND; Matthews, E; McNamara, JO; Pan, E; Schuetz, E | 1 |
| Boon, P; Carrette, E; Delbeke, J; Desloovere, J; Goossens, MG; Larsen, LE; Raedt, R; Vonck, K; Wadman, W | 1 |
| Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS | 1 |
| Andersson, M; Gonzalez-Ramos, A; Kokaia, M; Kudláček, J; Ledri, M; Mikroulis, A; Waloschková, E | 1 |
| Bleich, A; Buchecker, V; Koska, I; Pace, C; Palme, R; Potschka, H; Talbot, SR | 1 |
| Aguilera, P; Franco-Pérez, J; Manjarrez-Marmolejo, J; Sánchez-Hernández, J | 1 |
| Lisgaras, CP; Scharfman, HE | 1 |
| Hagman, S; Kapucu, FE; Kiiski, H; Lotila, J; Mzezewa, R; Narkilahti, S; Peltola, J; Vinogradov, A | 1 |
| Fernandez, AM; Grogan, DP; Gross, RE; Gutekunst, CA; Pedersen, NP | 1 |
| Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L | 1 |
| Baculis, BC; Bajaj, A; Christian-Hinman, CA; Chung, HJ; Huesmann, GR; Ibrahim, B; Jeong, HG; Kim, EC; Llano, DA; Tracy, GC; Walters, JM; Zhang, J | 1 |
| Kandeda, AK; Mabou, ST; Moutchida, C | 1 |
| Liu, SY; Shen, KF; Wang, J; Wang, ZK; Wu, KF; Wu, ZF; Yang, H; Yang, XL; Yue, J; Zhang, CQ; Zhu, G | 1 |
| Audinat, E; Blaquiere, M; Canet, G; deBock, F; Desrumaux, C; Garcia, V; Givalois, L; Hernandez, C; Marchi, N; Moreno-Montano, M; Planel, E; Vitalis, M; Zub, E; Zussy, C | 1 |
| Friedman, LK; Kahen, BA; Velíšek, L; Velíšková, J | 1 |
| Baluchnejadmojarad, T; Hashemi, P; Nazari-Serenjeh, M; Ramazi, S; Roghani, M; Tashakori-Miyanroudi, M | 1 |
| Chiu, KM; Hung, CY; Lee, MY; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Chiu, KM; Hsu, JH; Huang, CT; Jean, WH; Lee, MY; Lin, TY; Shieh, JS; Wang, SJ | 1 |
| Delandre, C; Fujimoto, S; Haginoya, K; Hamano, SI; Hirose, S; Inoue, Y; Ishii, A; Kaneko, S; Miyamoto, H; Moore, AW; Morimoto, M; Oguni, H; Ohmori, I; Osaka, H; Osawa, M; Pai, YJ; Raveau, M; Shimohata, A; Sudo, G; Suzuki, T; Takahashi, Y; Tatsukawa, T; Uematsu, M; Yamakawa, K | 1 |
| Christian-Hinman, CA; Cutia, CA; Ge, X; Leverton, LK; Raetzman, LT; Youssef, R | 1 |
| Borbély, S; Májer, T; Szádeczky-Kardoss, K; Szűcs, A; Világi, I | 1 |
| Hage, Z; Tsirka, SE; Victor, TR | 1 |
| Dong, D; Guo, L; Wang, F; Wu, B; Wu, Z; Zhang, T | 1 |
| Elahdadi Salmani, M; Goudarzi, I; Hosseinmardi, N; Lashkarbolouki, T; Moradpour, F; Nasudi, G | 1 |
| Chen, D; Gan, CL; Gu, X; Hu, L; Lee, TH; Li, R; Mei, Y; Shui, X; Tian, Y; Wang, J; Wang, L; Zhang, M; Zhang, T; Zou, Y | 1 |
| Cheng, Y; Cui, Y; Liang, J; Pan, X; Sun, H; Wang, Q; Xin, W; Yu, J; Zhai, Y; Zhang, M; Zhang, W | 1 |
| Adeyemi, OO; Afolayan, O; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Nwose, E; Olubodun-Obadun, TG; Umukoro, S | 1 |
| Bendaoud, M; El Idrissi, A; Mamchyn, A; Mekawy, N; Sadek, R; Shukurova, S; Yachou, Y | 1 |
| Ding, J; Li, Y; Liu, L; Wang, Q; Wang, X; Xia, L; Zhang, Y | 1 |
| Castillo, PE; Frechou, MA; Gonçalves, JT; Nasrallah, K; Persaud, S; Yoon, YJ | 1 |
| Duveau, V; Evrard, A; Gurrell, R; Iredale, P; Roucard, C; Ruggiero, C | 1 |
| Becker, AJ; Cases-Cunillera, S; Hamed, M; Müller, P; Opitz, T; Pitsch, J; Pohlentz, MS; Schoch, S; Surges, R; Vatter, H | 1 |
| Kang, TC; Kim, JE; Kim, MJ; Kim, TH; Lee, DS; Park, H | 1 |
| Bentley, R; Hu, G; Jiang, X; Lowe, S; Mei, H; Sun, C; Wu, Y; Xie, R; Zhao, W | 1 |
| Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H | 1 |
| Chang, A; Chang, Y; Wang, SJ | 1 |
| Calvani, M; Giovannini, MG; Lana, D; Landucci, E; Magni, G; Mazzantini, C; Pellegrini-Giampietro, DE | 1 |
| Antony, H; Audinat, E; Bedner, P; Breuer, A; Brosseron, F; Heneka, MT; Henning, L; Müller, J; Seifert, G; Singh, P; Steinhäuser, C | 1 |
| Barheier, N; Häussler, U; Kilias, A; Ruther, P; Tulke, S | 1 |
| Jung, SY; Kang, JW; Kim, DW; Kwon, HH; Park, H; Shin, HJ; Song, HJ | 1 |
| Aguirre-Aranda, I; Ángel Ávila-Rodríguez, M; Avendaño-Estrada, A; Diaz-Ruiz, A; Franco-Pérez, J; Islas-Cortez, M; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Ríos, C; Ruiz-Diaz, A | 1 |
| Krook-Magnuson, E; Smith, MM; Stieve, BJ | 1 |
| Hu, D; Liu, J; Ma, Y; Tang, F; Yan, Y; Zhang, Z | 1 |
| Dahal, A; Govindarajan, K; Kar, S | 1 |
| Baudin, P; Hanin, A; Lecas, S; Navarro, V; Roussel, D | 1 |
| Ahmadi, S; Hashemi, P | 1 |
| Hashemi, P; Izadpanah, E; Moloudi, MR; Vahabzadeh, Z | 1 |
| Biagini, G; Costa, AM; Gol, M; Lucchi, C | 1 |
| Chu, PC; Fisher, RS; Huang, CS; Ing, SZ; Liu, HL; Yu, HY | 1 |
| Chen, B; Guo, Y; Jiang, L; Lin, A; Lin, P; Tao, K; Xu, D; Zhang, H | 1 |
| Ahmadi, M; Bahi-Buisson, N; Billuart, P; Bun, P; Canaud, G; Elena, D; Le Pen, G; Le, M; Moriceau, S; Ouardi, DE; Pierani, A; Piskorowski, R; Ramezanidoraki, N; Rolland, D; Rouach, N | 1 |
| Chen, C; Dong, X; Fan, J; Gong, L; Huang, X; Jiang, J; Lin, D; Shen, W; Tang, Y; Wang, X; Xie, Y; Xu, A; Zeng, L; Zhang, X | 1 |
| Crotty, KM; Harbin, NH; Hepler, JR; Hurst, C; Lustberg, DJ; Pare, J; Seyfried, NT; Smith, Y; Waters, AL; Weinshenker, D; Yeligar, SM | 1 |
| Bowers, EK; Burbacher, T; Hendrix, AM; Lefebvre, KA; Marcinek, DJ; Stuppard, R | 1 |
| Chen, Y; Gu, Y; Liu, Z; Ma, Y; Sun, H; Tao, K; Tian, X; Wang, X; Wu, J; Zhang, X | 1 |
| Christian-Hinman, CA; Cutia, CA; Leverton, LK | 1 |
| Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M | 1 |
| Fu, T; Kong, H; Wang, Y; Zhuo, Z | 1 |
| Buszka, A; Dzwonek, J; Kalita, K; Kruk, PK; Nader, K; Olech-Kochańczyk, G; Skupien-Jaroszek, A; Wilczynski, GM; Wójtowicz, T; Worch, R; Włodarczyk, J | 1 |
| Geng, C; Li, A; Li, J; Liu, C; Liu, P; Wu, J; Zhu, Q | 1 |
| Du, TT; Gao, Y; Han, CL; Li, RP; Liang, K; Liu, C; Meng, FG; Shi, L; Wang, HZ; Wang, Q; Xue, T; Zhang, JG; Zhang, LW; Zhang, MX; Zhao, XM; Zhou, SY | 1 |
| Kovac, S; Saadi, A; Sandouka, S; Shekh-Ahmad, T; Taiwo, RO | 1 |
| Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R | 1 |
| Cao, Q; Guo, Y; He, J; Lin, A; Xu, D; Yang, X | 1 |
| Avoli, M; Fisher, TAJ; Kennedy, TE; Lévesque, M; Wang, S | 1 |
| Christian-Hinman, CA; Conklin, EA; Lawande, NV | 1 |
| Dzwonek, J; Grajkowska, W; Marchel, A; Matyja, E; Rysz, A; Skupien-Jaroszek, A; Szczepankiewicz, AA; Wilczynski, GM | 1 |
| Bischof, H; Ehinger, R; Lukowski, R; Matt, L; Pham, T; Ruth, P; Skrabak, D | 1 |
| Annamneedi, A; Blondiaux, A; Çalışkan, G; Dityatev, A; Fejtova, A; Gundelfinger, ED; Jia, S; Montenegro-Venegas, C; Nebel, J; Seidenbecher, CI; Stork, O; Walker, MC; Wykes, RC | 1 |
| Bukovac, A; Drexel, M; Matulewicz, P; Rahimi, S; Ramos-Prats, A; Salami, P; Schmuck, A; Tasan, RO | 1 |
| Colegrove, K; Cook, P; Dennison, S; Fauquier, D; Gulland, F; Rowles, TK; Simeone, C; Skidmore, J | 1 |
| Boon, P; Carrette, E; Christiaen, E; Craey, E; Descamps, B; Goossens, MG; Larsen, LE; Raedt, R; Vanhove, C; Vonck, K | 1 |
| Gao, X; He, M; Hu, Y; Huang, Z; Li, Y; Liu, H; Luo, Y; Ma, J; Ma, Y; Wang, Q; Wang, W; Wang, X; Wei, X; Xu, D; Yang, M; Yang, Q; Yang, Y; Zheng, F; Zhu, S | 1 |
| Auer, T; Erker, T; Schreppel, P; Schwarzer, C | 1 |
| Dong, S; Fan, M; Huang, Y; Wang, J; Zeng, L; Zheng, B; Zou, X | 1 |
| Cui, Y; Gao, X; Liu, S; Pan, X; Sun, H; Wang, Q; Yu, J; Zhang, M; Zhang, Y; Zhu, W | 1 |
| Binder, MS; Hodges, SL; Huebschman, JL; Lugo, JN; Nolan, SO; Okoh, JT; Reynolds, CD | 1 |
| Fan, Y; Hou, C; Jiang, G; Peng, S; Tang, F; Wang, X; Wang, Y; Yang, J; Yu, J | 1 |
| Baekelandt, V; Boon, P; Carrette, E; De Bundel, D; Delbeke, J; Desloovere, J; Goossens, MG; Larsen, LE; Merckx, C; Meurs, A; Raedt, R; Van den Haute, C; Vonck, K; Wadman, W | 1 |
| Aydin, S; Batugal, A; Cabangcala, AC; Daneman, R; Gimlin, K; Hashimoto, T; Korai, M; Kotoda, M; Munji, RN; Noble-Haeusslein, LJ; Oldham, MC; Schupp, PG; Semple, BD; Sohet, F; Soung, AL; Trivedi, A; Weiner, GA | 1 |
| Anjum, M; Brandt, C; Gericke, B; Hillmann, P; Kaczmarek, E; Löscher, W; Schidlitzki, A; Theilmann, W; Twele, F; Welzel, L | 1 |
| Chen, Y; Deng, J; Liu, X; Liu, Y; Ou, S; Tan, C; Wang, T; Xu, T; Yang, J; Yu, X; Yuan, J | 1 |
| Adhikari, A; Copping, NA; Petkova, SP; Silverman, JL | 1 |
| Arafat, MA; Irazoqui, PP; Jefferys, JGR; Lovick, TA | 1 |
| Chen, J; Duan, H; Geng, Z; Song, S; Wang, F; Wang, H; Xiao, P; Zhao, Y; Zhou, Y | 1 |
| Alvarez de la Rosa, D; Armas-Capote, N; Barios, JA; Barrio, LC; Giraldez, T; Hernandez, G; Lamas, JA; Maglio, LE; Martin-Batista, E; Pérez-Atencio, L; Reboreda, A | 1 |
| Cho, H; Jeon, BH; Kim, DW; Kim, HW; Lee, CJ; Lee, GS; Nam, MH; Neupane, C; Pandit, S; Park, JB; Sharma, R; Shin, N; Woo, J; Yi, MH | 1 |
| He, Q; Kuang, S; Lan, H; Sun, J; Weng, N; Xue, H; Yang, H; Zhang, L | 1 |
| Jung, H; Kim, H; Ko, J; Kwon, SK; Um, JW | 1 |
| Hong, J; Jung, UJ; Kim, SR; Lee, JM; Yoon, D | 1 |
| Bading, H; Bas-Orth, C; Buchthal, B; Koch, M; Lau, D | 1 |
| Bayat, A; Jones, A; Joshi, S; Koubeissi, MZ; Xiao, X | 1 |
| Benke, TA; Castano, A; O'Leary, H; Saba, LM; Southard, L; Vanderlinden, L | 1 |
| Albanna, W; Alpdogan, S; Hescheler, J; Neumaier, F; Schneider, T | 1 |
| Boon, P; Christiaen, E; Descamps, B; Goossens, MG; Larsen, LE; Raedt, R; Vanhove, C | 1 |
| Ishikawa, A; Maki, T; Mizuno, Y; Niimi, K; Oda, Y; Sakai, K; Takahashi, E; Tanaka, R | 1 |
| Chiang, CC; Chien, ME; Durand, DM; Hsu, KS; Huang, CH; Huang, CW; Lin, CC; Wu, YJ | 1 |
| Inoue, T; Sada, N; Suto, S; Suzuki, M; Usui, S | 1 |
| Dong, L; Hao, L; Shen, W; Wei, X; Yu, Q | 1 |
| Fox, P; Koh, S; Mithal, DS; Sanchez, RM; Somogyi, JR; Vien, AC | 1 |
| Cao, J; Gao, M; Rui, Y; Tang, C; Wang, L; Wang, Y; Xu, B; Yan, BC; Zhang, J | 1 |
| Biagini, G; Costa, AM; Lucchi, C; Rosal Lustosa, Í; Simonini, C | 1 |
| Edwards, SF; Huff, J; Metcalf, CS; Newell, TG; Thomson, KE; West, PJ; Wilcox, KS | 1 |
| Duerrwald, LM; Dulla, CG; Gerevich, Z; Klaft, ZJ | 1 |
| Bosco, DB; Li, Y; Richardson, JR; Wei, Y; Wu, LJ; Wu, W; Xie, M; Zhao, MG | 1 |
| Bayat, A; Joshi, S; Koubeissi, MZ; Kurada, L; Siddu, M; Skopin, MD; Zelano, CM | 1 |
| Abou Jaoude, M; Azmi, A; Cash, SS; Coughlin, BF; Ebrahim, S; Fumeaux, NF; Kadambi, A; Kimchi, EY; Metcalf, CS; Moraes, MFD; Nagaraj, SB; Newell, TG; Thomson, KE; Wilcox, KS; Xu, JX | 1 |
| Hoffman, DA; Hu, JH; Malloy, C | 1 |
| Hori, K; Novakovic, MM; Prakriya, M; Tsujikawa, S; Yamashita, M | 1 |
| Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH | 1 |
| Kim, JE; Lee, DS | 1 |
| He, H; Huang, Y; Lin, L; Pan, X; Wang, L; Wu, Y; Zhang, Y; Zhao, Y | 1 |
| Feixiang, S; Guo, M; Haiyan, G; Jiahang, S; Jie, L; Shengjie, S; Sihua, Q; Xiaoying, G; Yanmei, Z; Ying, C | 1 |
| Baluchnejadmojarad, T; Barati, H; Goudarzi, M; Jamali-Raeufy, N; Roghani, M | 1 |
| Moreira, JD; Müller, AP; Porciúncula, LO; Siqueira, LV; Souza, DO; Vinadé, L | 1 |
| Ashraf, O; Boison, D; Chitravanshi, V; Fedele, DE; Huynh, T; Murugan, M; Purnell, BS | 1 |
| Hou, L; Ji, W; Jiang, Y; Liu, K; Mao, L; Wu, F; Zhang, M; Zhao, G | 1 |
| Aronica, E; Cattalini, A; de Curtis, M; Gnatkovsky, V; Pereira, MF; Testa, G; van Vliet, EA; Vila Verde, D; Zimmer, T | 1 |
| Brindley, E; Campbell, A; Heller, JP; Henshall, DC; Jensen, MA; Langa, E; Miller, MT; Morris, G; Reschke, CR; Worm, J | 1 |
| Cai, X; Chen, C; Chen, Z; Cheng, H; Fan, X; Liu, J; Shen, Y; Tan, B; Tan, N; Wang, S; Wang, Y; Wu, X; Yu, J | 1 |
| Li, Y; Wang, P; Wang, Z; Yang, A; Zhang, Q; Zhang, Y | 1 |
| Banov, V; Itohara, S; Kandasamy, LC; Kato, M; Matsumoto, N; Nagasawa, Y; Ogawa, S; Takeda, J; Tsetsegee, S; Tsukamoto, M; Young, LJ; Zhang, Q | 1 |
| Costine-Bartell, B; Duhaime, AC; McGuone, D; Price, G; Shen, J; Staley, K | 1 |
| Metcalf, CS; Thomson, KE; West, PJ; Wilcox, KS | 1 |
| Achsel, T; Bagni, C; Buzzi, A; Gastaldo, D; Hilal, ML; Lo, AC; Rajan, N; Simonato, M; Telley, L | 1 |
| Ayata, C; Chung, DY; de Morais, AL; Endres, M; Loonen, ICM; Misra, A; Qin, T; Schiff, SJ; Schlunk, F; Tamim, I | 1 |
| Che, NW; Luan, ZL; Sun, XW; Wang, GY; Yan, DB; Yin, J; Zhang, C | 1 |
| Barker-Haliski, M; Knox, KM; Koneval, Z; Mizuno, S; White, HS; Zierath, DK | 1 |
| Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D | 1 |
| Audinat, E; Bacigaluppi, M; Cerovic, M; Di Nunzio, M; Di Sapia, R; Gullotta, GS; Kebede, V; Marchi, N; Ravizza, T; Sorrentino, D; Vezzani, A | 1 |
| Cheng, Y; Cui, Y; Huang, W; Li, S; Liu, W; Sun, H; Xin, W; Zhang, M; Zhang, Y; Zhu, W | 1 |
| Binder, DK; Cullion, K; Garcia, TA; Pedapati, EV; Peterson, AR; Tiwari-Woodruff, SK | 1 |
| Beyeler, A; Dubanet, O; Ferreira Gomes Da Silva, A; Frick, A; Hirase, H; Leinekugel, X | 1 |
| Cook, JK; Lee, KY; Liu, DC; Lizarazo, S; Tsai, NP | 1 |
| Hwang, Y; Kim, HC; Shin, EJ | 1 |
| Hu, LY; Liu, MJ; Shi, XY; Zou, LP | 1 |
| Liang Hsieh, C; Liao, ET; Lin, YW; Tang, NY | 1 |
| Kanamori, K | 1 |
| Arkhipov, VI; Kapralova, MV; Pershina, EV | 1 |
| Bayat, A; Connell, P; Jahan, S; Joshi, S; Koubeissi, MZ; Mukharesh, L; Siddu, M; Skopin, MD; Tsuchiya, K; Younes, N | 1 |
| Guo, D; Wong, M; Zou, J | 1 |
| García-Barba, C; Medina-Ceja, L | 2 |
| Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M | 1 |
| Abdelhalim, K; Genov, R; Kassiri, H; Salam, MT; Soltani, N; Tonekaboni, S; Velazquez, JLP | 1 |
| Brazete, CS; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI | 1 |
| Cincioğlu-Palabiyik, M; Ertoy-Baydar, D; Karahan, H; Kelicen-Uğur, P; Sara, Y; Üner, M | 1 |
| Chi, Y; Guan, J; Guo, Y; Li, X; Lu, Z; Rao, J; Wu, B; Xiao, K; Xu, Q; Xu, Y; Xue, S | 1 |
| An, XF; Liu, XJ; Yang, GS; Yu, D; Zhang, YJ; Zhou, XY | 1 |
| Tang, R; Tang, X; Yang, X; Yu, H | 1 |
| Li, Y; Liu, F; Lu, S; Tian, X; Wang, X; Xu, X; Yang, Q; Yang, Y; Zhang, Y; Zheng, F | 1 |
| Auladell, C; Beas-Zarate, C; Busquets, O; Camins, A; Castro-Torres, RD; Ettcheto, M; Folch, J; Verdaguer, E | 1 |
| Mong, MC; Wang, ZH; Yang, YC; Yin, MC | 1 |
| Bindila, L; Ellis, SR; Heeren, RMA; Lerner, R; Lutz, B; Post, JM; Vos, DRN | 1 |
| Aboulamer, S; Bosoi, CM; Carmant, L; Desgent, S; Gagné, J; Messiet, E; Sanon, NT; Simard, A; Wolf, DC | 1 |
| Aboufatima, R; Bezza, K; Chait, A; El Gabbas, Z; Ferehan, H; Kissani, N; Laadraoui, J; Marhoume, F; Sokar, Z; Wakrim, EM | 1 |
| Bayat, A; Chau, D; Connell, P; Forcelli, P; Jahan, S; Joshi, S; Koubeissi, MZ; Syed, T; Tsuchiya, K | 1 |
| Bragin, A; Engel, J; Kriukova, K; Li, L | 1 |
| Lauková, M; Shakarjian, MP; Velíšek, L; Velíšková, J | 1 |
| Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galati, C; Galli, F; Lattanzi, D; Minelli, A; Olivieri, F; Palma, E; Ruffolo, G; Saccomanno, S; Savelli, D; Torquato, P | 1 |
| Chang, Y; Chen, YJ; Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R | 1 |
| Iqbal, R; Jain, GK; Siraj, F; Vohora, D | 1 |
| Chen, W; Dolce, A; Hartman, AL; Hoke, A; Santos, P | 1 |
| Caballero-Chacón, S; Feria-Romero, IA; Morales-Sosa, M; Orozco-Suárez, S; Vega-García, A | 1 |
| Blauwblomme, T; Capelle, L; Chever, O; Couillin, I; Dossi, E; Guinard, E; Huberfeld, G; Le Bert, M; Moulard, J; Pallud, J; Rouach, N; Vasile, F | 1 |
| Fritschy, JM; Gfeller, T; Gschwind, T; Knuesel, I; Lafourcade, C; Rambousek, L; Zaichuk, M | 1 |
| Huang, WS; Zhu, L | 1 |
| Dhir, A | 1 |
| An, L; Chen, X; Huang, Z; Kårbø, M; Wang, K; Wang, R; Zhang, J; Zhao, Y | 1 |
| Bosco, DB; Eyo, UB; Feng, L; Huang, J; Peng, J; Richardson, JR; Tang, K; Wang, H; Wu, G; Wu, LJ; Xu, Z; Yan, C; Zheng, J | 1 |
| Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H | 1 |
| Boylan, GB; Henshall, DC; Jimenez-Mateos, EM; Madden, SF; Molloy, EJ; Quinlan, SMM; Rodriguez-Alvarez, N | 1 |
| Bu, G; Chen, Z; Li, Y; Pan, G; Xu, H; Zhang, Y; Zheng, H | 1 |
| Chen, Y; Du, T; Jiang, Y; Liu, D; Liu, Y; Meng, D; Shi, L; Zhang, J; Zhang, X; Zhu, G | 1 |
| Friedman, LK; Wongvravit, JP | 1 |
| Åbjørsbråten, KS; Enger, R; Heuser, K; Jensen, V; Nagelhus, EA; Nome, CG; Pettersen, KH; Sprengel, R; Tang, W; Taubøll, E | 1 |
| Hsieh, HL; Hsieh, TY; Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Kim, YB; Park, D; Yon, JM | 1 |
| Drexel, M; Kofler, B; Sperk, G; Sternberg’, F | 1 |
| Arafat, MA; Budde, RB; Irazoqui, PP; Jefferys, JGR; Lovick, TA; Pederson, DJ | 1 |
| Gray, WP; Pringle, A; Sadek, AR; Seifert, G; Shtaya, A; Steinhäuser, C; Zaben, M | 1 |
| Li, JY; Tian, RH | 1 |
| Chen, T; Deng, Y; Sha, L; Shen, Y; Xu, Q | 1 |
| Liu, YH; Qi, AQ; Qi, QD; Zhang, YH; Zhu, JL | 1 |
| Baron-Flores, V; Caballero-Chacón, S; Díaz-Ruiz, A; Farfán-Briseño, AC; Franco-Pérez, J; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Nava-Ruiz, C; Ríos, C; Ruiz-Diaz, A | 1 |
| Acar Arslan, E; Cansu, A; Dilber, B; Diler Durgut, B; Gürgen, SG; İnce, İ; Kamaşak, T; Şahin, S; Yazar, U | 1 |
| Caleo, M; Cattaneo, A; Costa, M; Mainardi, M; Olimpico, F; Pancrazi, L; Testa, G | 1 |
| Guan, X; Huang, K; Li, C; Li, S; Lu, B; Luo, Z; Xia, S; Xian, F; Zhang, J | 1 |
| Iwasawa, C; Narita, M; Tamura, H | 1 |
| Jiang, Z; Ping, A; Wang, Y; Xu, K; Zhang, F; Zheng, Y; Zhu, J; Zhu, W | 1 |
| Chen, M; Jia, C; Jiao, H; Wei, L; Yang, H; Yin, W; Zhang, R | 1 |
| Atanasova, D; Galchev, T; Kortenska, L; Lazarov, N; Marinov, P; Shishmanova-Doseva, M; Tchekalarova, J | 1 |
| Dingledine, R; Du, Y; Jiang, J; Kinjo, ER; Nguyen, HP; Yu, Y | 1 |
| Becker, AJ; Bikbaev, AF; Blaess, S; Dietrich, D; Heine, M; Martinez-Chavez, E; Müller, JA; Pitsch, J; Rummel, CK; Schoch, S; van Loo, KMJ | 1 |
| Dudek, FE; Grabenstatter, HL | 2 |
| Shi, XZ; Xu, Q | 1 |
| Gao, P; Huo, J; Niu, J; Sun, T; Wan, D; Wang, F; Wu, J; Yu, B; Zhang, J | 1 |
| Cheng, B; Cheng, Y; Fu, H; Huang, W; Li, X; Li, Y; Lu, P; Luo, H; Qi, Z; Rong, Z; Wang, X; Yao, Y; Ye, X; Zhang, YW; Zheng, H; Zheng, W | 1 |
| Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lepsveridze, E; Lortkipanidze, T; Margvelani, G; Solomonia, R; Tsverava, L | 1 |
| Chen, Y; Du, T; Liu, D; Liu, Y; Shi, L; Yuan, T; Zhang, J; Zhang, X; Zhu, G | 1 |
| Buzoianu-Anguiano, V; Feria-Romero, I; Magdaleno-Madrigal, VM; Morales-Otal, A; Orozco-Suárez, S; Rocha, L; Santana-Gómez, CE; Vega-García, A | 1 |
| Chen, Q; Huang, Z; Li, MH; Ma, WN; Sun, ZM; Zhao, XY | 1 |
| Li, X; Wang, X; Yan, J; Yang, H; Yuan, Y | 1 |
| Gao, X; Pan, X; Sun, H; Wang, Q; Yu, H; Yu, J; Zhang, M; Zhang, Y; Zhu, W | 1 |
| Díaz-Ruíz, A; Méndez-Armenta, M; Munguía-Martínez, MF; Nava-Ruíz, C; Ruíz-Díaz, A; Yescas-Gómez, P | 1 |
| Andrade, PA; Da Costa, C; Ferreira, MH; Lukoyanov, NV; Maia, GH; Soares, JI | 1 |
| Chen, O; Huang, S; Liu, J; Wang, Y; Xue, J; Zhu, W; Zhu, X | 1 |
| Bowman, CE; Ellis, JM; Selen Alpergin, ES; Wolfgang, MJ | 1 |
| Audinat, E; Barbier, E; Blaquiere, M; Boux, F; deBock, F; Klement, W; Lerner-Natoli, M; Marchi, N; Zub, E | 1 |
| Binder, DK; Peterson, AR | 1 |
| Chen, C; Feng, X; Mei, Q; Qiu, C; Tao, X; Wang, L; Zhu, J | 1 |
| Leung, LS | 1 |
| Chiu, KM; Lee, MY; Lin, TY; Lu, CW; Wang, MJ; Wang, SJ | 2 |
| Li, F; Liu, L | 1 |
| Kang, TC; Kim, JE; Kim, MJ; Lee, DS | 1 |
| Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G | 1 |
| Adeyemi, OO; Afolayan, OO; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Ojo, ES; Umukoro, S | 1 |
| Chesebro, B; Pathmajeyan, M; Race, B; Rangel, A; Striebel, JF | 1 |
| Altavilla, G; Barbanti-Brodano, G; Bonaccorsi, A; Brocca-Cofano, E; Busatto, G; Caputo, A; Cifelli, P; Corallini, A; De Michele, R; Fabris, M; Pittaluga, A; Simonato, M; Summa, M; Verlengia, G; Zucchini, S | 1 |
| Ramsdell, JS; Tiedeken, JA | 4 |
| Bergstrom, RA; Choi, JH; Howe, CL; Manduca, A; Shin, HS; Worrell, GA | 1 |
| Agresti, A; Antonelli, A; Aronica, E; Bianchi, ME; Carli, M; Iori, V; Iyer, AM; Maroso, M; Ravizza, T; Rizzi, M; Vertemara, R; Vezzani, A | 1 |
| Botta, J; Friedman, LK; Iacobas, DA; Iacobas, S; Kudur, V; Leheste, JR; Mancuso, J; Patel, A; Spray, DC | 1 |
| Adem, A; Amir, N; Azimullah, S; Hasan, MY; Ruan, Y; Sharkawi, SS; Zhang, XM; Zheng, XY; Zhu, J | 1 |
| Cynader, M; Fernando, S; Leavitt, BR; Lu, G; Petkau, TL; Zhu, S | 1 |
| Clapham, DE; Clish, CB; Jiang, D; Zhao, L | 1 |
| Blazejczyk, M; Caban, B; Jaworski, J; Kazmierska, P; Konopacki, J; Macias, M; Rodo, A; Skalecka, A; Tarkowski, B | 1 |
| Chen, YH; Chiang, YH; Chu, MT; Huang, EY; Kuo, TT; Ma, HI | 1 |
| Lin, KC; Wang, CC; Wang, SJ | 1 |
| Dhir, A; Rogawski, MA; Zolkowska, D | 1 |
| Albertson, AJ; Buckingham, SC; Davis Haselden, W; Hablitz, JJ; Lubin, FD; Mascia, KL; Ryley Parrish, R | 1 |
| Barbieri, M; Binaschi, A; Boschi, A; Buzzi, A; Couture, R; Ongali, B; Regoli, D; Rodi, D; Simonato, M; Verlengia, G; Zucchini, S | 1 |
| Benke, TA; Bernard, PB; Browning, MD; Castano, AM; O'Leary, H; Simpson, K | 1 |
| Huang, S; Li, B; Li, Z; Liu, J; Sun, R; Yin, P; Zhu, X | 1 |
| Gorter, JA; Qiao, X; van Vliet, EA; Wadman, WJ; Werkman, TR | 1 |
| Huang, L; van Luijtelaar, G | 1 |
| Koh, S; Mlsna, LM | 1 |
| Dou, W; Feng, J; Jin, L; Li, W; Sha, L; Sha, Z; Shen, Y; Wang, J; Wang, N; Wang, X; Wen, B; Wu, L; Wu, X; Xing, X; Xu, Q; Yao, Y | 1 |
| Di, Q; Hao, JB; Huang, XJ; Li, LC; Liu, H; Liu, XH; Su, LY; Yu, N; Zhang, YF | 1 |
| Takahashi, DK; Thomson, KE; Vargas, JR; Wilcox, KS | 1 |
| Abbasi, E; Bazahang, P; Lotfizadeh, M; Naserpour Farivar, T; Nassiri-Asl, M; Sadeghnia, HR; Sheikhi, M | 1 |
| Drexel, M; Kirchmair, E; Sperk, G | 1 |
| Kanamori, K; Ross, BD | 1 |
| Chang, PK; Charron, F; Dezsi, G; Gill, R; Huang, TC; Jones, NC; Machnes, ZM; McKinney, RA; O'Brien, TJ; Ozturk, E; Reist, N; Szyf, M | 1 |
| Fahim, E; Friedman, LK; Halbsgut, LR; Hong, H; Kapoor, K | 1 |
| Brown, MS; Frey, L; Huber, K; Lepkin, A; Schickedanz, A; Serkova, N | 1 |
| Atanasova, M; Ilieva, K; Ivanova, N; Pechlivanova, D; Tchekalarova, J | 1 |
| Chen, N; Gao, Y; Kong, DM; Liu, C; Meng, FG; Xing, WM; Yan, N; Zhang, JG | 1 |
| Aloisi, G; Capannolo, M; Ciccarelli, C; Fasciani, I; Fumagalli, F; Maggio, R; Molteni, R; Riva, MA; Rocchi, C; Romeo, S; Zani, BM | 1 |
| Lorenson, M; Morales, T; Ramos, E; Walker, AM | 1 |
| Aguirre-Moreno, A; Campos-Pena, V; Del Rio-Portilla, F; Herrera-Ruiz, M; Leon-Rivera, I; Montiel, E; Rodriguez, V; Tello, I; Villeda-Hernandez, J | 1 |
| Matthews, SA; Samson, KK; Simeone, KA; Simeone, TA | 1 |
| Liang, LP; Patel, M; Rivard, C; Ryan, K | 1 |
| Konat, GW; Michalovicz, LT | 1 |
| Sha, LZ; Sha, ZQ; Shen, Y; Wu, XF; Xu, Q | 1 |
| Acampora, D; Allegra, M; Bozzi, Y; Caleo, M; Di Giovannantonio, LG; Sanguinetti, E; Simeone, A; Tripathi, PP; Wurst, W | 1 |
| Cho, GJ; Choi, MY; Choi, WS; Jeon, BT; Kang, SS; Kim, HJ; Kim, YS; Lee, DH; Roh, GS | 1 |
| Jensen, FE; Klein, PM; Obeid, M; Rosenberg, EC | 1 |
| Choi, WS; Heo, RW; Kim, H; Kim, HJ; Kwon, HM; Roh, GS; Shin, HJ | 1 |
| Gulland, FM; Ramsdell, JS | 1 |
| Han, JW; Heo, RW; Kim, H; Kim, JS; Roh, GS; Shin, HJ; Yi, CO | 1 |
| Da Silva, RS; Menezes, FP; Rico, EP | 1 |
| Benson, DL; Huntley, GW; Matikainen-Ankney, BA; Nikitczuk, JS; Patil, SB; Scarpa, J; Shapiro, ML | 1 |
| Kajitani, K; Katogi, A; Nakabeppu, Y; Nestler, EJ; Nomaru, H; Ohnishi, YN; Sakumi, K; Tsuchimoto, D | 1 |
| Bayer, KU; Benke, TA; Bernard, PB; Castano, AM | 1 |
| Bialecki, RA; Kirkley, KA; Liang, LP; Miller, JA; Padmanabhan, R; Patel, M; Raol, YH; Tjalkens, RB | 1 |
| Fukui, M; Miyamoto, R; Nomura, S; Shimakawa, S; Tamai, H | 1 |
| Amankulor, N; Feng, X; Ghosal, K; Hambardzumyan, D; Holland, EC; Pitter, KL; Tamagno, I | 1 |
| Jin, EH; Kim, HJ; Kim, JS; Kwon, MS; Park, S; Song, W | 1 |
| Gmiro, VE; Serdyuk, SE; Veselkina, OS | 1 |
| Figiel, I; Kaczmarek, L; Konopka, A; Korkotian, E; Melikyan, A; Rutkowska-Wlodarczyk, I; Wilczyński, GM; Yeghiazaryan, M | 1 |
| Jin, Y; Kim, ID; Lee, JK; Luo, L | 1 |
| Aguilar-Guadarrama, B; Aguirre-Moreno, A; Campos-Peña, V; Castillo-España, P; Estrada-Soto, S; León-Rivera, I; Navarrete-Vázquez, G; Rios, MY; Rivera-Leyva, JC; Villeda-Hernández, J | 1 |
| Bhowmik, M; Saini, N; Vohora, D | 1 |
| Abad, S; Auladell, C; Camarasa, J; Camins, A; Escubedo, E; Junyent, F; Pallàs, M; Pubill, D | 1 |
| Elbrønd-Bek, H; Gøtzsche, CR; Olling, JD; Waterfield, A; Woldbye, DP; Wörtwein, G | 1 |
| Ali, SS; Friedman, LK; Naseer, Z; Slomko, AM; Wongvravit, JP | 1 |
| Avvisati, R; Di Tommaso, M; Fezza, F; Lanuti, M; Maccarrone, M; Marinelli, S; Marrone, MC; Mercuri, NB; Rapino, C | 1 |
| Hui, L; Shen, F; Sun, T; Wang, F; Wang, Z; Yang, G; Zhang, X; Zhao, X; Zhou, W; Zhou, X | 1 |
| Han, H; Jang, T; Jeong, JW; Kang, JS; Kim, IH; Lee, GW; Lee, JK | 1 |
| Donmez, G; Higashimori, H; Liu, L; Mason, A; Shih, J | 1 |
| Kamiński, K; Obniska, J; Wiklik, B | 1 |
| Bhowmik, M; Pottoo, FH; Vohora, D | 1 |
| Jung, JS; Kim, CH; Kim, SS; Lim, SM; Park, SH; Sharma, N; Sim, YB; Suh, HW | 1 |
| Ahmad, F; Blaesse, P; Kaila, K; Khirug, S; Puskarjov, M; Sivakumaran, S | 1 |
| Dragunow, M; During, MJ; Fong, DM; Glass, M; Lawlor, PA; McRae, M; Mouravlev, A; Wu, A; Young, D | 1 |
| Duncan, C; Gulland, FM; Kirkley, KS; Madl, JE; Tjalkens, RB | 1 |
| Schauwecker, PE | 6 |
| Liao, D; Liu, F; Liu, H; Luo, K; Song, Z; Yang, L; Zhang, T; Zhuang, K | 1 |
| Bhowmik, M; Khanam, R; Saini, N; Vohora, D | 1 |
| Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W | 1 |
| Bankstahl, M; Klein, S; Löscher, W | 1 |
| Doihara, T; Kobayashi, N; Li, C; Matsuda, S; Nabeka, H; Saito, S; Shimokawa, T; Takechi, H; Uematsu, K; Yamamiya, K | 1 |
| Burghardt, NS; Denny, CA; Drew, LJ; Friedman, D; Hen, R; Hsieh, J; Iyengar, SS; LaFrancois, JJ; Scharfman, HE; Wu, MV | 1 |
| MacKenzie, G; Maguire, J | 1 |
| Hutchinson, E; Meyerand, ME; Sayin, U; Sutula, T | 1 |
| Aizenman, E; Friedman, A; Gilad, D; Hershfinkel, M; Ketzef, M; Sekler, I; Shorer, S | 1 |
| Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Világi, I | 1 |
| Cao, Z; Cui, Y; Hulsizer, S; Lein, PJ; Pessah, IN; Wulff, H; Zou, X | 1 |
| Barco, A; Fiorenza, A; Geijo-Barrientos, E; Lopez-Atalaya, JP; Rovira, V; Scandaglia, M | 1 |
| Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA | 1 |
| Beitzel, CS; Benke, TA; Bernard, PB; Carlson, VB; Castano, AM | 1 |
| Dishman, RK; Holmes, PV; Murray, PS; Reiss, JI; Spradley, JM | 1 |
| Benson, MJ; Borges, K; Hodson, MP; Lynch, JW; Talwar, S; Thomas, NK; Woodruff, TM | 1 |
| Chang, SJ; Tsai, HL | 1 |
| Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Aliev, R; Kitchigina, V; Shubina, L | 2 |
| Alpar, A; Chen, R; Elphick, MR; Guggenhuber, S; Harasta, AE; Harkany, T; Kaiser, N; Kilb, W; Klugmann, M; Luhmann, HJ; Lutz, B; Mattheus, T; Monory, K; Purrio, M; Schmitz, N; Wickert, M | 1 |
| Inami, H; Kato, K; Ohno, K; Sakamoto, S; Shishikura, J; Yamashita, H; Yasunaga, T | 1 |
| Chen, CC; Chiang, WW; Chien, YC; Lien, CC; Lin, SH; Liu, YZ | 1 |
| Chiu, KM; Lee, MY; Wang, MJ; Wang, SJ; Wu, CC | 1 |
| Bankstahl, M; Klein, S; Löscher, W; Römermann, K; Twele, F | 1 |
| Chen, DJ; Liu, FR; Liu, JX; Wang, YZ; Xie, QM; Yang, XJ; Zeng, LH | 1 |
| Adamo, EB; Altavilla, D; Bitto, A; Calò, M; Galfo, F; Interdonato, M; Irrera, N; Marini, H; Minutoli, L; Pallio, G; Pizzino, G; Rinaldi, M; Squadrito, F; Trichilo, V | 1 |
| Chu, K; Hakimova, H; Jeon, D; Jeong, B; Kim, S; Lee, SK | 1 |
| Lei, GF; Li, BM; Li, J; Sun, RP; Wang, JW; Yin, P; Yu, L; Zhang, XT | 1 |
| Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y | 1 |
| Filipkowski, RK; Kaczmarek, L; Kondratiuk, I; Lukasiuk, K; Miszczuk, D; Plucinska, G; Szydlowska, K; Wozniak, G | 1 |
| Chen, B; Chen, X; Liu, SY; Lu, LX; Shu, HF; Wang, FX; Xiong, XY; Yang, H; Yang, QW; Zheng, X | 1 |
| Hartman, AL; Marie Hardwick, J; O'Riordan, KJ; Santos, P; Stafstrom, CE | 1 |
| Gupta, N; Higgins, R; Hoffman, DA; Kim, E; Lantz, CL; Murase, S; Quinlan, EM; Stopfer, M | 1 |
| Chan, JY; Chang, AY; Chao, YM; Ho, YH; Lin, YT; Wu, CW | 1 |
| Kumar, U; Mazarati, A; Medel-Matus, JS; Sankar, R; Shin, D; Washington, J | 1 |
| Kim, CH | 1 |
| Genov, R; Kassiri, H; Perez Velazquez, JL; Salam, MT | 1 |
| Aguilar-Calvo, P; Carulla, P; del Río, JA; Espinosa, JC; Ferrer, I; Gavín, R; Legname, G; Llorens, F; Matamoros-Angles, A; Torres, JM | 1 |
| Chen, Y; Lang, S; Li, R; Wang, X; Yang, N; Zhu, F; Zuo, P | 1 |
| Aronica, E; Boison, D; Bright, KA; Gorter, J; Hanthorn, M; Lytle, NK; Shen, HY; van Vliet, EA | 1 |
| Ohtsuka, T; Okano, H; Yano, M | 1 |
| Greene, DL; Hoshi, N; Kang, S; Kay, HY; Kosenko, A | 1 |
| Hong, SI; Jeong, HU; Kim, HG; Oh, MS | 1 |
| Chopra, K; Dhir, A | 1 |
| Andrade, JP; Andrade, PA; Leite, JF; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI | 1 |
| Choi, CH; Heo, RW; Kang, DH; Kim, H; Roh, GS; Yi, CO | 1 |
| Berretta, N; Cecconi, F; Cervelli, M; Cervetto, C; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Mercuri, N; Passalacqua, M; Ragazzoni, M; Venturini, A; Vergani, L; Voci, A | 1 |
| Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L | 1 |
| Blumberg, MS; Kaila, K; Pospelov, AS; Puskarjov, M; Yukin, AY | 1 |
| Araújo, IM; Carreira, BP; Carvalho, CM; Santos, AI; Santos, DF | 1 |
| An, EN; Chun, Y; Jin, EH; Kim, HJ; Kim, J; Park, S; Song, W | 1 |
| Chen, X; Dong, G; Wang, H; Yun, W; Zheng, C; Zhou, X | 1 |
| Maguire, J; Sivakumaran, S | 1 |
| Benke, TA; Bernard, PB; Castano, AM; O'Leary, H | 1 |
| Chavda, V; Dhir, A | 1 |
| Cook, A; DiMaio, J; Johnson, GVW; Nilsson, B; Pallo, SP | 1 |
| Bhandare, AM; Farnham, MM; Kapoor, K; Pilowsky, PM | 1 |
| Boon, P; Glorieux, G; Janssens, S; Lambrecht, BN; Portelli, J; Raedt, R; Thyrion, L; Van Loo, P; Vonck, K; Wadman, WJ | 1 |
| Bennett, IV; Nebeker, LD; Newell, TG; Thomson, KE; Tian, BB; Umpierre, AD; White, HS; White, JA; Wilcox, KS | 1 |
| Bouyssières, C; Bressand, K; Chabrol, T; Depaulis, A; Duveau, V; Pouyatos, B; Roche, Y; Roucard, C | 1 |
| Deshimaru, M; Hirose, S; Ihara, Y; Ishii, A; Tomonoh, Y; Uchida, T; Zhang, B | 1 |
| Cai, YL; Si, PP; Wang, WJ; Wang, WP; Zhen, JL | 1 |
| Akiyama, T; Akshoomoff, N; Arima-Yoshida, F; Grossfeld, PD; Manabe, T; Matsuura, K; Mattson, SN; Nakamura, T; Nasu-Nishimura, Y; Sakaue, F; Takeda, Y | 1 |
| Liu, J; Liu, Y; Liu, Z; Wang, F; Wang, S; Zhao, Y | 1 |
| Liu, HG; Meng, DW; Yang, AC; Zhang, JG; Zhang, K | 1 |
| Puttachary, S; Sharma, S; Thippeswamy, A; Thippeswamy, T | 1 |
| Chen, YH; Chiang, YH; Chou, YC; Hoffer, BJ; Huang, EY; Kuo, TT; Ma, HI; Tsai, JJ; Wu, PJ | 1 |
| Meng, ZY; Wang, FX; Wang, TG; Xiong, XY; Yang, MH; Yang, QW | 1 |
| Battaglia, G; Bellistri, E; Cipelletti, B; Colciaghi, F; de Curtis, M; Librizzi, L; Noé, FM | 1 |
| Atkinson, EW; Coleman, JE; Hoang-Minh, LB; Le, MM; Parker, AK; Sarkisian, MR; Semple-Rowland, S; Smith, TS; Ugartemendia, G | 1 |
| Lin, TY; Lu, CW; Wang, SJ | 1 |
| Hu, QP; Mao, DA | 1 |
| Abiega, O; Anderson, AE; Beccari, S; Brewster, AL; Deudero, JJ; Diaz-Aparicio, I; Domercq, M; Encinas, JM; Galbarriatu, L; Gómez-Nicola, D; Hui, CW; Layé, S; Leyrolle, Q; Maletic-Savatic, M; Marinas, A; Matute, C; Nadjar, A; Paris, I; Pérez-Samartín, A; Sánchez-Zafra, V; Savage, JC; Sierra, A; Tremblay, MÈ; Valero, J; Vivanco, Md; Zaldumbide, L | 1 |
| Fu, H; He, W; Li, Z; Wang, F; Yao, Y; Zhan, L; Zhang, X; Zhang, Y; Zheng, H; Zheng, W | 1 |
| Asadi-Shekaari, M; Esmaeili-Mahani, S; Esmaeilpour, K; Khodamoradi, M; Sheibani, V | 1 |
| Alikashani, A; Do Carmo, S; Najyb, O; Rassart, E | 1 |
| Baba, S; Burnham, WM; Kakizawa, S; Matsuo, T; Mori, N; Nagata, I; Ohyama, K; Onga, K; Otsubo, H; Scott, BW; Yasuda, K | 1 |
| Kim, H; Kim, WH; Lee, JY; Park, KJ; Roh, GS | 1 |
| Dawson, HN; Fan, Q; Ghosal, K; Pimplikar, SW | 1 |
| Dhamne, SC; Gersner, R; Pascual-Leone, A; Rotenberg, A; Zangen, A | 1 |
| Sha, LZ; Sha, ZQ; Xu, Q | 1 |
| Hao, HW; Li, LM; Liu, HG; Meng, DW; Qiao, H; Shi, L; Yang, AC; Yang, LC; Zhang, JG; Zhang, K | 1 |
| Hu, Q; Li, X; Liu, L; Mao, D; Shi, J; Tan, M; Xiong, J; Yi, Z | 1 |
| Ciarlone, SL; D'Agostino, DP; Grieco, JC; Weeber, EJ | 1 |
| Cooray, G; Friston, K; Marinazzo, D; Moran, R; Papadopoulou, M; Rosch, R | 1 |
| Chen, LL; Dong, JY; Kai, JJ; Wu, ML; Wu, XM; Zeng, LH; Zhu, F | 1 |
| Bassell, GJ; Danielson, SW; Danzer, SC; Engel, T; Gross, C; Henshall, DC; Jimenez-Mateos, EM; Pun, RYK; Rowley, S; Schroeder, LM; Thomas, KT; Tiwari, D; Xing, L; Yao, X | 1 |
| Gudelsky, GA; Herman, JP; Huff, CL; Morano, RL; Yamamoto, BK | 1 |
| Lugo, JN; Smith, GD; White, J | 1 |
| Arjomandi, H; Guzman, L; Ihsan, M; Kollmar, R; Lazar, J; Nakase, K; Nunez, A; Orman, R; Savoca, E; Silverman, J; Stefanov, D; Stewart, M; Stiles, K; Sundaram, K; Tordjman, L; Weedon, J | 1 |
| Bukovac, A; Drexel, M; Dum, E; Fürtinger, S; Gasser, E; Sperk, G; Tasan, R | 1 |
| Ji, Y; Jiang, N; Jin, J; Lin, W; Wang, Z; Wu, H; Zhao, Y; Zhu, H | 1 |
| Akatsu, H; Hashizume, Y; Ikegami, K; Setou, M; Vu, HT | 1 |
| Asari, MA; K N S, S; Mohd Sairazi, NS; Mummedy, S; Muzaimi, M; Sulaiman, SA | 1 |
| Liu, T; Mu, X; Sun, X; Xiao, T; Zhao, C; Zhao, M; Zhou, Z; Zhu, G | 1 |
| Ho, WH; Lee, WT; Lin, YC; Liu, CL; Yang, MT | 1 |
| Bayat, A; Connell, P; Joshi, S; Koubeissi, MZ | 1 |
| Kollmar, R; Nakase, K; Silverman, J; Stewart, M; Sundaram, K; Villiere, SM | 1 |
| Brandt, C; Klee, R; Löscher, W; Töllner, K | 1 |
| Ba, M; Fu, Q; Nai, Y; Sun, X; Wu, F; Zhang, Y | 1 |
| Hunsberger, HC; Konat, GW; Reed, MN | 1 |
| Albert, GW; Howard, MA; Schnizler, MK; Severson, MA; Welsh, MJ; Wemmie, JA; Ziemann, AE | 1 |
| Mello, LE; Queiroz, CM | 1 |
| Aguilar, MB; Castillo, CG; Freed, WJ; Giordano, M; Mendoza-Trejo, S | 1 |
| Lee, JK; Singh, AK; Singh, I; Won, JS | 1 |
| Chow, JP; Fujikawa, A; Noda, M; Shimizu, H | 1 |
| Craig, LA; Hong, NS; Kopp, J; McDonald, RJ | 1 |
| Bachstetter, A; Barnes, GN; Blalock, EM; Gant, JC; Hauser, KF; Kotick, J; Li, Y; Mervis, R; Schauwecker, PE; Smith, GM; Thibault, O; Yang, J | 1 |
| Benke, TA; Cornejo, BJ; Mesches, MH | 1 |
| Gaestel, M; Hitti, E; Kotlyarov, A; Potschka, H; Thomas, T | 1 |
| Behl, C; Clement, AB; Deussing, JM; Hanstein, R; Holsboer, F; Lu, A; Wurst, W | 1 |
| Antonucci, F; Berghuis, P; Bonanno, G; Caleo, M; Carmignoto, G; Dobszay, MB; Grumelli, C; Harkany, T; Matteoli, M; Pozzi, D; Verderio, C | 1 |
| El Idrissi, A; L'Amoreaux, WJ | 1 |
| Bozzi, Y; Di Giovannantonio, LG; Simeone, A; Tripathi, PP; Viegi, A; Wurst, W | 1 |
| Carroll, JC; Pike, CJ; Rosario, ER | 1 |
| Holland, PT; Kerr, DS; Mountfort, DO; Sawant, PM | 1 |
| Chae, JS; Jeong, JH; Kim, AY; Kim, HC; Kim, SC; Kim, WK; Ko, KH; Koh, YH; Nah, SY; Shin, EJ; Yen, TP; Yoon, HJ | 1 |
| Jeong, JH; Kim, AY; Kim, HC; Kim, HJ; Kim, WK; Ko, KH; Koh, YH; Kwon, YS; Nah, SY; Shin, EJ; Wie, MB; Yoneda, Y | 1 |
| Bozzi, Y; Brilli, E; Casarosa, S; Köhler, M; Scali, M | 1 |
| Ljubicić, D; Pelcić, JM; Simonić, A; Vitezić, D; Vitezić, M; Zupan, G | 1 |
| Bosetti, F; Kingsley, PJ; Marnett, LJ; Toscano, CD | 1 |
| Gorter, JA; Lopes da Silva, FH; Queiroz, CM; Wadman, WJ | 1 |
| Hiraga, K; Ishii, Y; Kato, I; Kawaguchi, H; Mohafez, OM; Sasahara, M; Shehata, MH; Takasawa, A; Takasawa, K; Yoshida, T | 1 |
| Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS | 1 |
| Balosso, S; Bartfai, T; Frasca, A; Maroso, M; Ravizza, T; Sanchez-Alavez, M; Vezzani, A | 1 |
| Birnbaum, D; Harrington, M; Jensen, FE; Muller, P; Pascual-Leone, A; Riviello, JJ; Rotenberg, A | 1 |
| Auladell, C; Camins, A; Duque, D; Junyent, F; Pallàs, M; Romero, R; Utrera, J | 1 |
| Cho, GJ; Choi, WS; Han, JY; Jeon, BT; Kang, SS; Kim, HJ; Lee, DH; Lee, JY; Roh, GS; Shin, HJ | 1 |
| Honda, N; Nishimura, A; Shibata, N; Sugioka, N; Takada, K | 1 |
| Hotta, H; Koizumi, K; Stewart, M | 1 |
| Bedner, P; Frank, S; Hüttmann, K; Steinhäuser, C; Theis, M; Theofilas, P | 1 |
| Hall, DG; Jordan, WH; Reams, RY; Sharma, AK; Snyder, PW | 1 |
| Cosgrave, AS; McKay, JS; Morris, R; Quinn, JP; Thippeswamy, T | 2 |
| Bozzi, Y; Casarosa, S; Corsini, GU; Scali, M; Sgadò, P; Simon, HH; Tripathi, PP; Vaglini, F; Viaggi, C | 1 |
| Boison, D; Kaplan, DL; Li, T; Ren, G | 1 |
| Kong, D; Ma, R; Wang, L; Wu, Z; Xu, Q; Zhang, L | 1 |
| Aujla, PK; Fetell, MR; Jensen, FE | 1 |
| Clark, S; Dudek, FE; Ferraro, DJ; Staley, KJ; Swiercz, W; White, AM; Williams, PA | 1 |
| Lorenzana, A; Schauwecker, PE; Wood, RI | 1 |
| Boyd, HE; Dishman, RK; Holmes, PV; Reiss, JI; Robinson, JK | 1 |
| Ben-Ari, Y; Khalilov, I; Nardou, R | 1 |
| Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH | 1 |
| Perry, MA; Ryan, CL; Tasker, RA | 1 |
| During, MJ; Kalev-Zylinska, ML; Symes, W; Young, D | 1 |
| Alfaro-Rodríguez, A; Arch-Tirado, E; Carrasco-Portugal, M; González-Piña, R; Labra-Ruiz, N; Padilla-Martin, K; Pérez-Guillé, B; Soriano-Rosales, RE; Uribe-Escamilla, R | 1 |
| Cho, GJ; Choi, WS; Jeon, BT; Kang, SS; Kim, HJ; Kim, KH; Lee, DH; Roh, GS | 1 |
| Chung, HY; Handa, S; Ishigami, A; Kim, K; Kim, MS; Kim, SJ; Lee, J; Maruyama, N; Park, HR; Son, TG | 1 |
| Bilodeau, GA; Carmant, L; Courtemanche, R; Langlois, JM; Lema, P; Lévesque, M | 1 |
| Fawcett, JW; Raha-Chowdhury, R; Watts, C; Zhao, JW | 1 |
| Rensing, NR; Wong, M; Zeng, LH | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Ho, TY; Hsieh, CL; Liu, CH; Lo, WY; Su, SY; Tang, NY | 1 |
| Gunther, T; Hüll, M; Schüle, R; Schulte, EC; Slawik, H | 1 |
| Luna-Medina, R; Martinez, A; Morales-Garcia, JA; Perez-Castillo, A; Santos, A | 1 |
| Beltramino, CA; Pereno, GL | 1 |
| Baba, T; Date, I; Jing, M; Kondo, A; Miyoshi, Y; Morimoto, T; Murakami, M; Shingo, T; Tajiri, N; Tanabe, M; Uozumi, T; Wang, F; Yasuhara, T; Yuan, WJ; Zhao, S | 1 |
| Boison, D; Li, T; Shen, HY | 1 |
| Boison, D; Lan, JQ; Li, T | 1 |
| Han, D; Li, C; Pei, DS; Wang, WW; Xu, B; Yu, HM; Yu, XJ; Zhang, GY; Zhu, J | 1 |
| Agari, T; Borlongan, CV; Date, I; Kameda, M; Kikuchi, Y; Kondo, A; Kuramoto, S; Matsui, T; Miyoshi, Y; Shingo, T; Yasuhara, T | 1 |
| Kerr, DS; Mountfort, DO; Sawant, PM | 1 |
| Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM | 1 |
| Ander, BP; Jickling, G; Liu, DZ; Sharp, FR; Stamova, BS; Tian, Y; Turner, RJ; Xu, H; Zhan, X | 1 |
| Barresi, V; Belluardo, N; Condorelli, DF; Mudò, G; Trovato-Salinaro, A | 1 |
| Belforte, JE; Jinde, S; Nakazawa, K; Tonegawa, S; Wilson, MA; Yamamoto, J | 1 |
| Giorgi, FS; Hasson, H; Malhotra, S; Moshé, SL; Rosenbaum, DM | 1 |
| Ingole, S; Jain, G; Jain, R; Kaur, N; Meena, CL; Monga, V; Rajput, SK; Sharma, SS; Singh, JN | 1 |
| Duncan, GE; Inada, K; Koller, BH; Moy, SS | 1 |
| Agostinho, PM; Cognato, GP; Cunha, RA; Hockemeyer, J; Müller, CE; Souza, DO | 1 |
| Godlevskii, LS; Kobolev, EV; Kresyun, VI | 1 |
| Baracskay, P; Czurkó, A; Juhász, G; Kékesi, KA; Kiglics, V | 1 |
| Cardoso, AL; Costa, P; Culmsee, C; de Almeida, LP; de Lima, MC; Plesnila, N; Simões, S; Wagner, E | 1 |
| Henshall, DC; Jimenez-Mateos, EM; Matsushima, S; Taki, W; Tanaka, K | 1 |
| Berezin, V; Bock, E; Kiryushko, D; Korshunova, I; Pankratova, S; Sonn, K; Zharkovsky, A | 1 |
| Baldwin, RA; Jäger, AK; Niquet, J; Pedersen, ME; Stafford, GI; van Staden, J; Wasterlain, CG | 1 |
| Cloix, JF; Hévor, T; Martin, B; Tahi, Z | 1 |
| Kubová, H; Mares, P; Tchekalarova, J | 1 |
| Blake, BL; Criswell, HE; Gray, SJ; Li, W; McCown, TJ; Nicolson, SC; Samulski, RJ | 1 |
| Hong, JT; Jo, YJ; Kim, HC; Kim, YB; Nam, SY; Oh, KW; Yang, S; Yoon, SR | 1 |
| Cymerblit-Sabba, A; Schiller, Y | 1 |
| Chen, LG; Hou, WC; Hung, LF; Liang, YC; Lin, SY; Shen, YJ; Wang, CK; Wen, CL; Yen, SJ | 1 |
| Chan, SH; Chang, AY; Chang, WN; Chen, SD; Chuang, YC; Lin, TK; Liou, CW; Lu, CH | 1 |
| Hirakawa, K; Kurumaji, A; Nariai, T; Ohno, K; Ohta, Y | 1 |
| Balducci, C; Bland, R; Carli, M; During, MJ; Fitzsimons, H; Noe, F; Sperk, G; Vaghi, V; Vezzani, A; Zardoni, D | 1 |
| Hagiwara, S; Iwasaka, H; Koga, H; Matsumoto, S; Noguchi, T; Shingu, C; Yokoi, I | 1 |
| Aronica, E; Balosso, S; Bianchi, ME; Casalgrandi, M; Iyer, AM; Liu, J; Manfredi, AA; Maroso, M; Molteni, M; Ravizza, T; Rossetti, C; Vezzani, A | 1 |
| Kim, Y; Lee, J; Li, E; Lim, E; Park, S | 1 |
| Holopainen, IE; Jalava, N; Kukko-Lukjanov, TK; Laurén, HB; Lintunen, M; Lopez-Picon, FR; Michelsen, KA; Panula, P | 1 |
| Jin, T; Mix, E; Quezada, HC; Winblad, B; Zhang, XM; Zhu, J | 1 |
| Giné, E; Morales-Garcia, JA; Perez-Castillo, A; Santos, A | 1 |
| Holland, PT; Kerr, DS; Mountfort, DO; Peake, BM; Sawant, PM; Tyndall, JD | 1 |
| Jelen, N; Ule, J; Zivin, M | 1 |
| Bergbower, E; Hardwick, JM; Hartman, AL; Kennedy, M; Zheng, X | 1 |
| French, A; Gasior, M; Hartman, AL; Rogawski, MA; Yankura, J | 1 |
| Baranov, E; Brooks-Kayal, AR; McRae, PA; Porter, BE; Sarode, S | 1 |
| Hashizume, K; Hori, T; Kato, K; Maehara, M; Okada, Y; Tanaka, T; Urino, T | 1 |
| Hotta, H; Orman, R; Stewart, M; Watanabe, N | 1 |
| Abe, K; Hasebe, N; Hosoi, R; Inoue, O; Sugiyama, E | 1 |
| Cerbón, M; Morales, T; Tejadilla, D | 1 |
| He, W; Hu, X; Wilson, CG; Wong, P; Xiong, W; Yan, R; Yang, J; Zhou, X | 1 |
| Connor, TJ; Gleeson, LC; Griffin, EW; Harkin, A; Ryan, KJ | 1 |
| Kato, N; Kudo, K; Maru, E; Shibasaki, T; Sugaya, Y | 1 |
| Funakoshi, T; Kobayashi, S; Ohashi, S; Tanaka, T | 1 |
| Borrelli, E; Bozzi, Y; Brilli, E; Santorufo, G; Tripathi, PP | 1 |
| Chen, CC; Hsieh, CL; Lin, SZ; Liu, CH; Lo, WY; Shyu, WC; Su, SY; Tang, NY; Tsai, FJ | 1 |
| Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S | 1 |
| Muha, N; Ramsdell, JS | 1 |
| Angehagen, M; Christiansen, SH; Elbrønd-Bek, H; Gøtzsche, CR; Hansen, TV; Kanter-Schlifke, I; Kokaia, M; Nikitidou, L; Olesen, MV; Sørensen, AT; Woldbye, DP | 1 |
| Bernásková, K; Matejovská, I; Rokyta, R; Schutová, B; Slamberová, R | 1 |
| Gupta, SK; Irazoqui, PP; Markandeya, HS; Raghunathan, S; Roy, K | 1 |
| Cho, GJ; Choi, MY; Choi, WS; Jeon, BT; Kang, SS; Kim, HJ; Kim, YH; Kim, YS; Lee, DH; Roh, GS | 1 |
| Conroy, RM; Henshall, DC; Jimenez-Mateos, EM; Mouri, G | 1 |
| Depaulis, A; Deransart, C; Devaux, B; Hamelin, S; Häussler, U; Langlois, M; Pallud, J | 1 |
| Agrawal, L; Chekmasova, A; Louboutin, JP; Marusich, E; Strayer, DS | 1 |
| Chemaly, N; Cherubini, E; Eugène, E; Gustincich, S; Krmac, H; Lazarevic, D; Le Duigou, C; Marstrand, T; Miles, R; Motti, D; Sandelin, A; Sanges, R; Stupka, E; Valen, E; Wittner, L | 1 |
| Friedman, LK; Goldstein, B; Hallas, BH; Keesey, R; LaTorre, GN; Mehta, V; Rafiuddin, A; Rudenko, V; Saghyan, A; Sharma, A | 1 |
| Alapafuja, SO; Bahr, BA; Butler, D; Hwang, J; Karanian, DA; Makriyannis, A; Naidoo, V; Nikas, SP; Vadivel, SK; Wood, JT; Zhao, J | 1 |
| Kawahara, S; Kiyama, H; Konishi, H; Morino, M; Ohata, K | 1 |
| Gu, P; Hou, Y; Li, Y; Shang, Y; Zhao, S | 1 |
| Ishimoto, T; Izumi, H; Mori, H; Nishijo, H; Yamamoto, H | 1 |
| Fan, M; Gong, DZ; Han, DY; Sun, CK; Sun, YP; Zhao, J | 1 |
| Andrews, G; Chen, TT; Noebels, JL; Qian, J; Xu, K; Yoo, J | 1 |
| Ahmad, AS; Doré, S; Lopez, PH; Mehta, NR; Rowland, EA; Schnaar, RL; Toner, M; Zhang, J | 1 |
| Claycomb, RJ; Hewett, JA; Hewett, SJ | 2 |
| Chen, L; Kong, S; Qian, B; Sun, Y; Wan, L; Wang, Y; Wang, ZY; Wu, Z; Zhang, B; Zhang, F | 1 |
| Beleboni, RO; Cunha, AO; dos Santos, WF; Fachim, HA; Faggion, SA; Gavin, AS; Pereira, AM | 1 |
| Borysiewicz, E; Fil, D; Kirschman, LT; Konat, GW | 1 |
| Bellaver, B; Bogo, MR; Bonan, CD; Casali, E; Cognato, GP; Savio, LE; Sévigny, J; Souza, DO; Vuaden, FC | 1 |
| Goto, K; Hozumi, Y; Saino-Saito, S | 1 |
| Caballero-Caballero, A; Engel, T; Henshall, DC; Jimenez-Mateos, EM; Prehn, JH; Tanaka, K | 1 |
| Alfaro, JM; Burgos, JS; Ripoll-Gómez, J | 1 |
| Aigner, C; Herzog, H; Schunk, E; Schwarzer, C; Stefanova, N; Wenning, G | 1 |
| Di, Q; Hu, Y; Jiang, Y; Liu, H; Yan, YK; Yu, N; Zhang, YD; Zhang, YF | 1 |
| Fujita, M; Kanamatsu, T; Ohtomo, T; Takagi, M; Yamada, J | 1 |
| Velíšek, L | 1 |
| Balosso, S; French, J; Iori, V; Maroso, M; Ravizza, T; Vezzani, A; Wright, CI | 1 |
| Irazoqui, P; Rajdev, P; Ward, M | 1 |
| Setou, M; Sugiura, Y; Taguchi, R | 1 |
| Anier, K; Aonurm-Helm, A; Jaako, K; Kalda, A; Shastin, D; Zharkovsky, A; Zharkovsky, T | 1 |
| Acosta, MT; Guerron, DA; Munashinge, J; Theodore, WH; Vortmeyer, A; Zhang, L | 1 |
| Drexel, M; Kirchmair, E; Preidt, AP; Sperk, G | 1 |
| Ares, M; Black, DL; Damianov, A; Gehman, LT; Lin, CH; Maguire, J; Mody, I; Shiue, L; Stoilov, P | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Wilhelm, EA | 1 |
| Harrison, JC; Kerr, DS; Sammut, IA; Sawant, PM; Vranyac-Tramoundanas, A | 1 |
| Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC | 1 |
| Alfaro-Rodríguez, A; Arch-Tirado, E; Ávila-Luna, A; Bueno-Nava, A; González-Piña, R; Uribe-Escamilla, R; Vargas-Sánchez, J | 1 |
| Chakrabarti, A; Hota, D; Sahai, AK; Sood, N | 1 |
| Borsotto, M; Coppola, T; Gandin, C; Heurteaux, C; Labbal, F; Mazella, J; Moha Ou Maati, H; Veyssiere, J; Widmann, C | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Rambo, LM; Ribeiro, LR; Roman, SS; Royes, LF; Wilhelm, EA | 1 |
| Blusztajn, JK; Glenn, MJ; Mellott, TJ; Tognoni, CM; Williams, CL; Wong-Goodrich, SJ | 1 |
| Ängehagen, M; Christiansen, SH; Gøtzsche, CR; Kokaia, M; Nikitidou, L; Olesen, MV; Sørensen, AT; Sørensen, G; Woldbye, DP | 1 |
| Arnspiger, S; Guo, D; Rensing, NR; Wong, M | 1 |
| Biagini, G; Bresciani, E; Coco, S; Gualtieri, F; Locatelli, V; Marinelli, C; Torsello, A; Vezzali, R | 1 |
| Caille, D; Charollais, A; Lutz, SE; Meda, P; Patel, NK; Santiago, MF; Scemes, E; Veliskova, J | 1 |
| Li, LY; Li, T; Liu, PP; Wang, Y; Zhang, HM | 1 |
| Baille, V; Barbier, L; Beaup, C; Carpentier, P; Depaulis, A; Dhote, F; Dorandeu, F; Heinrich, C; Peinnequin, A; Pernot, F | 1 |
| Banares, S; Hakem, R; Head, BP; Hu, Y; Huang, X; Krajewska, M; Krajewski, S; Kress, C; Kyoda, T; Leyva, R; Reed, JC; Rong, J; Salmena, L; Sze, CH; Whalen, MJ; Yang, J; You, Z | 1 |
| Boison, D; Lan, JQ; Li, T; Lytle, N; Sandau, US | 1 |
| Ahima, RS; Dhir, R; Lee, EB; Warmann, G | 1 |
| Fujihara, H; Hachisuka, K; Ishikura, T; Iwanaga, M; Katoh, A; Nomura, M; Ohbuchi, T; Ohno, M; Ueta, Y | 1 |
| Friedman, LK; Leheste, JR; Rafiuddin, A; Rudenko, V | 1 |
| Fujihara, H; Hachisuka, K; Hamamura, A; Ishikura, T; Iwanaga, M; Katoh, A; Ohbuchi, T; Ohno, M; Todoroki, M; Ueta, Y | 1 |
| Adem, A; Mao, XJ; Mix, E; Pham, T; Winblad, B; Zhang, HL; Zhang, XM; Zheng, XY; Zhu, J | 1 |
| Armağan, G; Benyhe, S; Bojnik, E; Borsodi, A; Kanıt, L; Turunç, E; Yalçın, A | 1 |
| Ali, A; Constance, JE; Dua, Y; Dudek, FE; Franklin, MR | 1 |
| Athie, A; Davila, J; Friedman, WJ; Goff, LA; Hart, RP; Lapid-Volosin, M; Pichardo-Casas, I; Ramos-Brossier, M; Swerdel, MR; Vaca, L | 1 |
| Diaz-Hernandez, M; Engel, T; Garcia-Huerta, P; Gomez-Villafuertes, R; Henshall, DC; Mesuret, G; Miras-Portugal, MT; Sanz-Rodriguez, A; Tanaka, K | 1 |
| Maggio, N; Segal, M | 1 |
| Hao, H; Li, L; Liu, X; Ma, Y; Yang, A; Yang, L; Zhang, J | 1 |
| Chen, Y; Cottingham, C; Greengard, P; Jiao, K; Liu, Y; McMahon, L; Wang, Q | 1 |
| Arellano, JL; Binder, DK; Hsu, MS; Lee, DJ; Seldin, MM | 1 |
| Gill, DA; McGuire, EP; Pérez-Gómez, A; Perry, MA; Tasker, RA | 1 |
| Fine, AS; Gunnar, E; Kazlauskas, C; Mogul, DJ; Nicholls, D; Sobayo, T | 1 |
| Clinckers, R; Massie, A; Smolders, I; Vermoesen, K | 1 |
| Henshall, DC; Jimenez-Mateos, EM; Matsushima, S; Reynolds, JP; Sano, T; Taki, W | 1 |
| Alfaro, JM; Burgos, JS; Sánchez, S; Sierra, S | 1 |
| Fitzgerald, EC; Jackson, MC; Jensen, FE; Joseph, A; Klein, PM; Lan, VJ; Sun, H; Talos, DM; Zhou, X | 1 |
| Glavan, G; See, RE; Živin, M | 1 |
| Chiba, Y; Hasegawa-Ishii, S; Hosokawa, M; Shimada, A; Takei, S; Uekawa, A; Umegaki, H; Watanabe, K; Woodward, DF | 1 |
| Kinoshita, C; Kinoshita, Y; Morrison, RS; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Li, C; Wei, XW; Wu, YP; Xu, B; Yan, H; Zhang, GY | 1 |
| Dell'acqua, ML; El-Husseini, A; Gibson, ES; Kang, R; Keith, DJ; Olszewski, K; Robertson, HR; Sanderson, JL; Woolfrey, KM | 1 |
| Adamowicz, WO; Bove, SE; Cadelina, GW; Carmel, S; Drummond, EM; Dumin, JA; Kleiman, RJ; Lanz, TA; Mariga, A; Pilsmaker, CD; Swetter, BJ | 1 |
| Brandt, C; Löscher, W; Rattka, M | 1 |
| Conroy, RM; DeFelipe, J; Delanty, N; Engel, T; Farrell, MA; Henshall, DC; Jimenez-Mateos, EM; McKiernan, RC; Merino-Serrais, P; Mouri, G; O'Brien, DF; O'Tuathaigh, C; Prenter, S; Sano, T; Stallings, RL; Tanaka, K; Waddington, JL | 1 |
| Airaksinen, AM; Gröhn, OH; Hekmatyar, SK; Huttunen, JK; Jerome, N; Kauppinen, RA; Niskanen, JP; Pitkänen, A | 1 |
| Dou, WC; Jin, LR; Sha, LZ; Wu, LW; Xing, XL; Xu, Q; Yao, Y; Zhang, D | 1 |
| Bray, I; Henshall, DC; Jimenez-Mateos, EM; McKiernan, RC; Sano, T; Simon, RP; Stallings, RL | 1 |
| Chung, JH; Kim, JW; Kim, SK; Park, HJ | 1 |
| Doo, AR; Kim, JH; Kim, SN; Kim, ST; Kim, SY; Kim, YY; Lee, H; Park, HJ; Yin, CS | 1 |
| Chung, PW; Jin, DK; Kim, BJ; Kim, YB; Lee, SH; Lee, YT; Moon, HS; Park, KY; Park, YS; Suh, BC; Yoon, WT | 1 |
| Cho, GJ; Choi, WS; Jeon, BT; Jeong, EA; Kang, SS; Kim, HJ; Lee, DH; Park, SY; Roh, GS; Shin, HJ; Son, H | 1 |
| Huang, Q; Huo, Z; Lin, Z; Liu, W; Lu, D; Qiao, W; Shen, H; Sun, J; Xie, C | 1 |
| Hattiangady, B; Rao, MS; Shetty, AK; Shuai, B | 1 |
| Al-Saudi, R; Engel, T; Henshall, DC; Heverin, M; Jimenez-Mateos, EM; Meaney, S | 1 |
| Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T | 1 |
| Ahn, SY; Han, JY; Hong, JT; Kim, CS; Kim, HC; Kim, SK; Oh, KW; Yoo, SK | 1 |
| Chu, K; Jeon, D; Jung, S; Kim, BS; Lee, SK; Yang, H | 1 |
| Dolce, A; Hardwick, JM; Hartman, AL; Santos, P | 1 |
| Kim, HJ; Kim, IK; Lee, J; Park, S; Song, W | 1 |
| Antonucci, F; Bozzi, Y; Braida, D; Caleo, M; Clerici, M; Corradini, I; De Astis, S; Donzelli, A; Frassoni, C; Inverardi, F; Lipp, HP; Loos, M; Martucci, R; Matteoli, M; Pattini, L; Sala, M; Verderio, C; Welzl, H; Wolfer, D | 1 |
| Chen, J; Fei, Z; Gao, Y; Li, L; Liu, W; Yang, Y | 1 |
| Chang, M; Fitzgerald, E; Folkerth, RD; Jensen, FE; Kosaras, B; Murphy, A; Talos, DM | 1 |
| Ambartsumian, N; Berezin, V; Bock, E; Dmytriyeva, O; Kiryushko, D; Lopez-Hoyos, M; Lukanidin, E; Marsolais, A; Owczarek, S; Pankratova, S; Ridley, CM; Sonn, K; Soroka, V | 1 |
| Bozzi, Y; Dunleavy, M; Henshall, DC; Provenzano, G | 1 |
| Bouwalerh, H; Maccari, S; Mairesse, J; Marrocco, J; Morley-Fletcher, S; Ngomba, RT; Nicoletti, F; Pittaluga, A; Silletti, V; Summa, M; Van Camp, G | 1 |
| Chow, M; Dedeurwaerdere, S; Egan, GF; Faggian, N; Fang, K; Noordman, I; O'Brien, TJ; Porritt, M; Shen, YT; van Raay, L | 1 |
| Fitzgerald, EF; Huganir, RL; Hunganir, RL; Jensen, FE; Klein, PM; Rakhade, SN; Sun, H; Zhou, C | 1 |
| Bird, A; Cobb, SR; Ganley, R; McLeod, F; Selfridge, J; Williams, L | 1 |
| Armagan, G; Benyhe, S; Bojnik, E; Borsodi, A; Kanit, L; Turunc Bayrakdar, E; Yalcin, A | 1 |
| Huang, SY; Li, Z; Qiao, NN; Sun, RP; Wang, JW; Wang, YY; Yin, P | 1 |
| Alvestad, S; Amiry-Moghaddam, M; Hammer, J; Hoddevik, EH; Ottersen, OP; Skare, Ø; Sonnewald, U | 1 |
| Bregola, G; Candeletti, S; Frigati, L; Reinscheid, R; Romualdi, P; Simonato, M; Zucchini, S | 1 |
| Araki, T; Bonislawski, DP; Henshall, DC; Lan, JQ; Meller, R; Minami, M; Schindler, CK; Simon, RP; Skradski, SL | 1 |
| Cha, JH; Choi, JS; Choi, YS; Chun, MH; Chung, JW; Kim, ON; Kim, SY; Lee, MY; Lee, SB | 1 |
| Bengzon, J; Ekdahl, CT; Lindvall, O; Mohapel, P | 1 |
| Dudek, FE; Ferraro, DJ; Hellier, JL; Staley, KJ; Williams, PA | 1 |
| Cavalheiro, EA; Garcia-Cairasco, N; Leite, JP | 1 |
| Ciceri, P; Isakson, PC; Leahy, KM; Seibert, K; Shaffer, AF; Smith, WG; Woerner, MB; Zhang, Y | 1 |
| Koylu, EO; Manev, H; Pogun, S; Uz, T | 1 |
| Akaike, K; Fukumoto, S; Takigawa, M; Tanaka, S; Tojo, H | 1 |
| Boda, B; Mas, C; Muller, D | 1 |
| Berkovic, SF; Clark, M; Drago, J; Finkelstein, DI; Horne, MK; Massalas, JS; McColl, C; Powney, E; Ross, SA; Wong, JY | 1 |
| De Micheli, C; De Sarro, A; De Sarro, G; Ferreri, G; Grasso, S; Micale, N; Puja, G; Toma, L; Zappalà, M | 1 |
| Gray, WP; May, K; Sundström, LE | 1 |
| Araki, T; Henshall, DC; Lan, JQ; Schindler, CK; Simon, RP; Taki, W; Tiekoter, KL | 1 |
| Amato, G; Belluardo, N; Condorelli, DF; Mirone, MB; Mudò, G; Trovato-Salinaro, A | 1 |
| Hashizume, K; Hodozuka, A; Nakai, H; Sawamura, A; Tanaka, T; Tsuda, H; Yoshida, K | 1 |
| Chavkin, C; Jin, W; Lou, D; Xu, M; Zhang, J | 1 |
| Katayama, T; Maekawa, K; Minami, M; Nakamura, J; Satoh, M; Yamakuni, H | 1 |
| Huh, Y; Kang, M; Lee, J; Lee, S; Park, C; Park, K; Whang, K | 1 |
| Carmant, L; Emond, M; Meilleur, S; Psarropoulou, C; Renaud, J | 1 |
| Dagci, T; Koylu, EO; Pogun, S; Tan, M; Tan, U | 1 |
| Kuno, M; Matsuura, S; Miyamoto, R; Nakamura, F; Shimakawa, S; Suzuki, S; Takitani, K; Tamai, H; Tanabe, T; Tanaka, K; Wakamiya, E; Watanabe, Y | 1 |
| Binaschi, A; Bregola, G; Candeletti, S; D'Addario, C; Landuzzi, D; Reinscheid, R; Rodi, D; Romualdi, P; Simonato, M; Zucchini, S | 1 |
| Lee, SC; Scharfman, HE; Schwarcz, R; Wu, HQ | 1 |
| Alfaro, A; Ayala-Guerrero, F; Campos-Sepúlveda, E; Martínez, C; Mexicano, G; Vargas, L | 1 |
| Bergamaschi, M; Buzzi, A; Pietra, C; Simonato, M; Villetti, G; Zucchini, S | 1 |
| Aasly, J; Eloqayli, H; Müller, B; Qu, H; Sonnewald, U | 1 |
| Goodman, JH; Jackson, MB; Scharfman, HE; Smith, KL; Sollas, AL | 1 |
| Cepeda, C; Cohen, RW; Crawford, CA; Levine, MS; Margulies, JE; Watson, JB | 1 |
| Friedman, MN; Geula, C; Herzog, AG; Holmes, GL | 1 |
| Bing, G; Im, DH; Jhoo, WK; Kang, KS; Kim, HC; Kim, WK; Ko, KH; Shin, EJ | 1 |
| Bing, G; Bok Wie, M; Choi, SG; Flanders, KC; Hong, JS; Jhoo, WK; Kim, HC; Kim, SJ; Kim, WK; Ko, KH; Shin, EJ | 1 |
| Aoki, T; Konishi, Y; Matsu-ura, T; Mikoshiba, K; Naranjo, JR; Tamura, TA | 1 |
| Kriz, J; Simonić, A; Zupan, G | 1 |
| Blasco-Ibáñez, JM; Crespo, C; Domínguez, MI; Marqués-Marí, AI; Martínez-Guijarro, FJ | 1 |
| Cho, GJ; Choi, WS; Chung, KM; Kang, SS; Kim, DW; Kim, YS; Lee, HP; Noh, HS | 1 |
| Iinuma, K; itoyama, Y; Onodera, H; Yoshihara, Y | 1 |
| Einheber, S; Milner, TA; Pierce, JP; Skyers, PS | 1 |
| Lu, A; Nee, AC; Ran, R; Sharp, FR; Tang, Y | 1 |
| Akbar, MT; de Belleroche, J; Dolatshad, H; Latchman, DS; Liu, K; Lundberg, AM; Vidyadaran, S; Wells, DJ; Wells, KE; Wynn, S | 1 |
| Armstrong, EA; Miyashita, H; Wirrell, EC; Yager, JY | 1 |
| Hong, YM; Jo, DG; Jung, YK; Kim, SY; Lee, MC | 1 |
| Brown-Croyts, LM; Caton, PW; McPherson, SL; Radecki, DT | 1 |
| Li, QY; Patel, M | 1 |
| Henderson, JM; Watson, SH | 1 |
| Clement, AB; Cravatt, BF; Hawkins, EG; Lichtman, AH | 1 |
| Mohanan, PV; Yamamoto, HA | 2 |
| Mancera-Flores, M; Osorio-Rico, L; Ríos, C | 1 |
| Gmiro, VE; Gorbunova, LV; Lukomskaya, NY; Rukoyatkina, NI | 1 |
| Baram, TZ; Dorenbos, K; Dubé, C; Steward, O; Sullivan, PG | 1 |
| Hirate, M; Nisibaba, D; Oku, N; Takeda, A; Tamano, H | 1 |
| Gale, K; Glosch, CE; Gluckman, BJ; Gwinn, RP; Moon, JB; Richardson, KA; Schiff, SJ; Weinstein, SL | 1 |
| Giza, CC; Hovda, DA; Lee, SM; Vespa, PM; Zanier, ER | 1 |
| Fiskum, G; Hoffman, GE; Moore, N; Murphy, AZ | 1 |
| Campbell, IL; Criado, J; Henriksen, SJ; Huitron-Resendiz, S; Masliah, E; Samland, H | 1 |
| Hirate, M; Oku, N; Takeda, A; Tamano, H | 1 |
| Haberman, RP; McCown, TJ; Samulski, RJ | 1 |
| Brown, SA; Hanscom, HN; Lawrence, DA; Moore, E; Smith, EP; Winkles, JA; Yepes, M | 1 |
| Henshall, DC; Quan-Lan, J; Saugstad, JA; Schindler, CK; Shinoda, S; Simon, RP; Taki, W | 1 |
| Koh, JY; Lee, SK; Sato, TA; Yi, JS | 1 |
| Araki, T; Henshall, DC; Lan, JQ; Schindler, CK; Shinoda, S; Simon, RP | 1 |
| Fujita, M; Hasegawa, D; Hashizume, K; Igarashi, H; Nakamura, S; Ohkubo, S; Orima, H; Takahashi, K | 1 |
| Banks, WA; Bland, RJ; Cao, L; Drucker, DJ; During, MJ; Fitzsimons, HL; Francis, JS; Haile, CN; Jiao, X; Klugmann, M; Zuzga, DS | 1 |
| Jovanovic, M; Radenovic, L; Selakovic, V; Vasiljevic, I | 1 |
| Charton, G; Chollet, AM; Décanis, N; Hanessian, S; Jourquin, J; Khrestchatisky, M; Le Diguardher, T; Rivera, S; Tremblay, E | 1 |
| Fei, J; Guo, LH; Ma, YH; Mei, ZT; Zhao, WJ | 1 |
| Dillman, WH; Hong, S; Kayama, T; Liu, J; Matsumori, Y; Panter, SS; Swanson, RA; Tsuchiya, D; Weinstein, PR | 1 |
| McKhann, GM; Robbins, CA; Schwartzkroin, PA; Sosunov, AA; Wenzel, HJ | 1 |
| Belluardo, N; Condorelli, DF; Mirone, MB; Mudò, G; Trovato-Salinaro, A | 1 |
| Baer, K; During, MJ; Lin, EJ; Richichi, C; Vezzani, A; Young, D | 1 |
| Pike, CJ; Ramsden, M; Shin, TM | 1 |
| Dai, YW; Du, MX; Jiang, XD; Liu, ZL; Luo, CY; Xu, RX; Yang, ZJ; Zou, YX | 1 |
| Hasegawa, M; Kurazono, S; Mori, S; Okamoto, M; Oohira, A; Sakiyama, J; Usui, S | 1 |
| Kim, JH; Koh, JY; Lee, JY; Palmiter, RD | 1 |
| Jessberger, S; Kempermann, G | 1 |
| Gray, WP; Hinterkeuser, S; Hüttmann, K; Kirchhoff, F; Sadgrove, M; Steinhäuser, C; Wallraff, A | 1 |
| Chun, JT; Crispino, M; Tocco, G | 1 |
| Becker, A; Burkhardt, K; Chen, J; Löscher, W; Potschka, H; Volk, HA | 1 |
| Sloviter, RS; Zappone, CA | 1 |
| Fukui, S; Ishihara, S; Nawashiro, H; Nomura, N; Otani, N; Shima, K; Tsuzuki, N | 1 |
| Katoh, H; Miyazawa, T; Nawashiro, H; Ohnuki, A; Otani, N; Shima, K; Yano, A | 1 |
| Chen, Z; Concha, HQ; Ljunggren, HG; Mix, E; Winblad, B; Yu, S; Zhu, J; Zhu, Y | 1 |
| Gale, K; Kondratyev, A | 1 |
| Liang, LP; Patel, M | 2 |
| Hermans-Borgmeyer, I; Hermey, G; Hübner, CA; Kuhl, D; Plath, N; Schaller, HC | 1 |
| Hoshika, A; Miyajima, T; Nishikawa, Y; Tachibana, M; Takami, T; Takashima, S; Takei, Y | 1 |
| Henshall, DC; Schindler, CK; Shinoda, S; Simon, RP | 1 |
| Colella, D; During, MJ; Grignaschi, G; Lin, EJ; Ravizza, T; Richichi, C; Sperk, G; Stefanin, D; Veglianese, P; Vezzani, A | 1 |
| Gobbo, OL; O'Mara, SM | 1 |
| Hirate, M; Oku, N; Takeda, A | 1 |
| Pérez-Clausell, J; Riba-Bosch, A | 1 |
| Banerjee, M; Kaminski, RM; Rogawski, MA | 1 |
| Bol'shakov, KV; Gmiro, VE; Gorbunova, LV; Lukomskaya, NY; Magazanik, LG; Rukoyatkina, NI | 1 |
| Li, TF; Lu, CZ; Luo, YM | 1 |
| Araki, T; Henshall, DC; Meller, R; Quan-Lan, J; Schindler, CK; Shinoda, S; Simon, RP; Taki, W | 1 |
| Armstrong, EA; Jaharus, C; Saucier, DM; Wirrell, EC; Yager, JY | 1 |
| Jensen, FE; Koh, S; Simpson, JN; Tibayan, FD | 1 |
| Adamo, EB; Altavilla, D; Bellomo, M; Bitto, A; Bonaccorso, MC; Calapai, G; Laureanti, F; Marini, H; Marini, R; Minutoli, L; Passaniti, M; Seminara, P; Squadrito, F | 1 |
| Anderson, AE; Leung, V; Misonou, H; Misonou, K; Mohapatra, DP; Park, EW; Trimmer, JS; Zhen, D | 1 |
| Dong, M; Fan, Y; Toepfer, NJ; Wu, Y; Xu, M; Zhang, J | 1 |
| Castrén, E; Knuuttila, J; Lähteinen, S; Pitkänen, A; Törönen, P | 1 |
| Lian, XY; Stringer, JL | 1 |
| Santos, JB; Schauwecker, PE; Williams, RW | 1 |
| Armellin, M; Bregola, G; Cattaneo, A; Giulianini, PG; Paradiso, B; Simonato, M; Steward, O; Tongiorgi, E; Zucchini, S | 1 |
| Almajano, J; Bragin, A; Engel, J; Mody, I; Wilson, CL | 1 |
| Choi, JS; Choi, YS; Kim, J; Kim, SY; Lee, MY; Min, DS; Park, HJ; Sung, KW | 1 |
| Fujiki, M; Inoue, R; Ishii, K; Kobayashi, H | 1 |
| Guo, SH; Lei, GF; Sun, RP; Wang, JW; Wang, YL | 1 |
| Auladell, C; Bellmann, A; Domínguez, MI; Ferrer, I; Journot, L; Valente, T | 1 |
| Brucklacher, R; Housman, C; Towfighi, J; Vannucci, RC | 1 |
| Barczynski, B; Tutka, P; Wielosz, M | 1 |
| Aparicio, LC; Binaschi, A; Candeletti, S; Di Benedetto, M; Landuzzi, D; Lopetuso, G; Mantovani, S; Mazzuferi, M; Romualdi, P; Simonato, M | 1 |
| Conneely, OM; Pönniö, T | 1 |
| Anderson, AE; Johnston, D; Leung, V; Lin, X; Shah, MM | 1 |
| Brandt, C; Ebert, U; Löscher, W | 1 |
| Lian, XY; Stringer, JL; Zhang, ZZ | 1 |
| Abu Rialy, S; Farhat, F; Francis, E; Geha, G; Kurdit, RM; Lteif, L; Maraashli, W; Mikati, MA; Rahmeh, AA | 1 |
| Hoshika, A; Miyajima, T; Nagashima, C; Nishikawa, Y; Sunohara, D; Tachibana, M; Takami, T; Takei, Y | 1 |
| Bennett, SA; Cheung, EC; Cregan, SP; Ferguson, KL; McIntosh, WC; Melanson-Drapeau, L; Park, DS; Slack, RS; Vanderluit, JL | 1 |
| Cha, JY; Chen, CF; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lim, YK; Nah, SY; Shin, EJ | 1 |
| Narkilahti, S; Pitkänen, A | 1 |
| Löscher, W; Potschka, H; Volk, H | 1 |
| Cho, GJ; Choi, WS; Kang, SS; Kim, DW; Noh, HS | 2 |
| Chan, T; Lu, TA; Quach, N; Schreiber, SS; Tan, Z | 1 |
| Da Silva, AG; Gilby, KL; McIntyre, DC | 1 |
| Cunha, RA; Lopes, LV; Oliveira, CR; Porciúncula, LO; Rebola, N; Soares-da-Silva, P | 1 |
| González-Trujano, ME; Hong, E; López-Meraz, ML; Neri-Bazán, L; Rocha, LL | 1 |
| Kang, HG; Kim, MR; Kim, YB; Oh, SH; Sok, DE | 1 |
| Cho, GJ; Choi, WS; Han, JY; Kang, SS; Kim, DW; Kim, YH; Noh, HS; Park, CH | 1 |
| Aoki, T; Kinoshita, M; Kitano, Y; Komiyama, C; Makino, M; Sakurada, S; Satoh, H; Takasuna, K; Takazawa, A; Yamauchi, T | 1 |
| Briyal, S; Gupta, YK | 1 |
| Hoexter, MQ; Mello, LE; Rosa, PS; Tufik, S | 1 |
| Bennett, AH; Duman, RS; Hunsberger, JG; Newton, SS; Selvanayagam, E | 1 |
| Babu, H; Jessberger, S; Kempermann, G; Römer, B | 1 |
| Balosso, S; Beck-Sickinger, AG; Colmers, WF; El Bahh, B; Gehlert, DR; Hamilton, T; Herzog, H; Sperk, G; Vezzani, A | 1 |
| Almajano, J; Azizyan, A; Bragin, A; Engel, J; Wilson, CL | 1 |
| Barton, ME; Shannon, HE | 1 |
| Busceti, CL; Faetti, M; Ferrucci, M; Fornai, F; Giorgi, FS; Giusiani, M; Lazzeri, G; Murri, L; Pizzanelli, C; Pontarelli, F | 1 |
| Chechlacz, M; Gilliams-Francis, K; Lamonica, K; Lin, SL; Liu, J; Naegele, JR; Navarro-Quiroga, I; Neema, M | 1 |
| Janeczko, K; Janicka, D; Kowalczyk, A; Setkowicz, Z; Turlej, A | 1 |
| Benke, TA; Brumback, AC; Delpire, E; Dzhala, VI; Jensen, FE; Mathews, GC; Sdrulla, DA; Staley, KJ; Talos, DM | 1 |
| Rokyta, R; Slamberová, R | 1 |
| Jin, RF; Sun, RP; Xu, XP | 1 |
| Brooks, AI; During, MJ; Klaussner, BC; Klugmann, M; Leichtlein, CB; Symes, CW; Young, D | 1 |
| Fritschy, JM; Kralic, JE; Ledergerber, DA | 1 |
| Hillered, L; Kunz, T; Marklund, N; Oliw, EH | 1 |
| Matsumoto, K; Murakami, Y; Sumanont, Y; Tohda, M; Vajragupta, O; Watanabe, H | 2 |
| Carter, J; Gao, X; Li, L; Tourtellotte, WG; Whitehead, J | 1 |
| Doi, T; Nagatomo, K; Nakajima, A; Tokumaru, J; Ueda, Y | 1 |
| Masumizu, T; Mori, A; Noda, Y; Packer, L | 1 |
| Ledeen, RW; Lu, ZH; Meyenhofer, MF; Wang, J; Wang, Y; Wu, G; Xie, X | 1 |
| Bernard, A; Chaillan, FA; Charton, G; Dive, V; Jourquin, J; Khrestchatisky, M; Marchetti, E; Rivera, S; Roman, FS; Soloway, PD; Tremblay, E; Yiotakis, A | 1 |
| Fan, Y; Li, T; Lu, C; Luo, Y; Xiao, B | 1 |
| Clark, S; Dudek, FE; Ferraro, DJ; Kadam, SD; Staley, KJ; White, AM; Williams, PA | 1 |
| Cole, TB; Luquet, S; Palmiter, RD; Ste Marie, L | 1 |
| Joseph, SA; Siddiqui, AH | 1 |
| Coulson, JM; Mori, N; Morii, H; Nakano, I; Yamada, T | 1 |
| Lacaille, JC; Lapointe, V; Perez, Y; Ratté, S; Sanon, N | 1 |
| Leung, LS; Wu, K | 1 |
| Bazan, NG; Christoffersen, NR; Kolko, M; Varoqui, H | 1 |
| Heida, JG; Pittman, QJ; Teskey, GC | 1 |
| Benkovic, SA; Miller, DB; O'Callaghan, JP | 1 |
| Lado, FA | 1 |
| Chung, H; Koh, S; Mahadevia, A; Song, Y; Xia, H | 1 |
| Caccamese, S; De Sarro, G; Grasso, S; Grazioso, G; Menniti, FS; Micale, N; Parrinello, N; Postorino, G; Roda, G; Zappalà, M | 1 |
| Deschamps, K; Dubreuil, CI; Marklund, N; McIntosh, TK; McKerracher, L | 1 |
| Hattiangady, B; Rao, MS; Reddy, DS; Shetty, AK | 1 |
| Aurelian, L; Gober, MD; Golembewski, EK; Gyure, KA; Laing, JM; Thompson, SM; Yarowsky, PJ | 1 |
| Koizumi, K; Saito, T; Sakamoto, K; Stewart, M | 1 |
| Johnson, GV; Roth, KA; Tucholski, J | 1 |
| Kishimoto, K; Kita, Y; Shimizu, T; Yoshikawa, K | 1 |
| Baran, H | 1 |
| Guan, QH; Liu, XM; Pei, DS; Sun, YF; Wang, XT; Zhang, GY; Zhang, QX | 1 |
| Avramescu, S; Ilie, A; Moldovan, M; Nita, DA; Spulber, S; Zagrean, AM; Zagrean, L | 1 |
| Baer, K; During, MJ; Herzog, H; Lin, EJ; Young, D | 1 |
| Castillo, CG; Freed, WJ; Giordano, M; Mendoza, S | 1 |
| Kim, YJ; Lee, CJ; Lee, U; Yoo, YM | 1 |
| Nehlig, A; Pereira de Vasconcelos, A; Riban, V; Wasterlain, C | 1 |
| McCown, TJ | 1 |
| Pike, CJ; Ramsden, M; Rosario, ER | 1 |
| Blackshear, PJ; Eun, SY; Jo, SA; Jo, SH; Kang, KS; Kim, EH; Kim, HJ; Kim, J; Kim, SJ | 1 |
| Belyaev, ND; Buckley, NJ; Chandler, KE; Coulson, JM; Haddley, K; Howard, MR; Hughes, D; Kipar, A; Quinn, JP; Spencer, EM; Stewart, JP; Walker, MC | 1 |
| Maehara, M; Matsumura, K; Sugiura, H; Takemiya, T; Yamagata, K; Yasuda, S | 1 |
| Avallone, J; Friedman, LK; Gashi, E; Magrys, B | 1 |
| Allan, S; Balosso, S; Bernardino, L; Ku, G; Lucas, SM; Malva, J; Noé, F; Randle, JC; Ravizza, T; Vezzani, A | 1 |
| Itoh, H; Oku, N; Takeda, A; Tamano, H | 1 |
| Johnson, DA; Johnson, JA; Kan, YW; Kraft, AD; Lee, JM | 1 |
| Inokuchi, K; Kataoka, M; Kuwahara, R; Matsuo, R; Sekiguchi, M; Takahashi, M | 1 |
| Imai, H; Kato, N; Minabe, Y; Nishimura, T; Sawa, A | 1 |
| McLin, JP; Steward, O | 1 |
| Brenner, M; Fukui, S; Gomi, H; Nawashiro, H; Ohsumi, A; Ooigawa, H; Otani, N; Shima, K; Toyooka, T | 1 |
| Bick-Sander, A; Blanquet, V; Bliss, TV; Bösl, MR; Cooke, SF; Dammermann, B; Engelsberg, A; Errington, ML; Fernandez, E; Grant, SG; Gross, C; Kobalz, U; Kuhl, D; Lipp, HP; Mahlke, C; Mao, X; Ohana, O; Plath, N; Salmen, B; Schmitz, D; Stawrakakis, A; Therstappen, E; Waltereit, R; Welzl, H; Wolfer, DP; Wurst, W | 1 |
| Brandt, M; Ehninger, D; Jessberger, S; Kempermann, G; Klempin, F; Kronenberg, G; Plümpe, T; Rodriguez, GR; Römer, B; Steiner, B | 1 |
| Fornai, F; Giorgi, FS; Iudice, A; Lazzeri, G; Murri, L; Natale, G; Paparelli, A; Ruggieri, S | 1 |
| Bing, G; Chae, JS; Cheon, MA; Jung, ME; Kim, HC; Kim, WK; Ko, KH; Nah, SY; Shin, EJ; Wie, MB | 1 |
| Chung, H; Koh, S; Magid, R; Stine, CD; Wilson, DN | 1 |
| Borges, K; Dingledine, R; Shaw, R | 1 |
| El Hokayem, JA; El Sabban, ME; Mikati, MA | 1 |
| Aguzzi, A; Burgaya, F; Del Río, JA; Gavín, R; Rangel, A; Soriano, E | 1 |
| Benke, TA; Browning, MD; Cornejo, BJ; Coultrap, S; Mesches, MH | 1 |
| Hirase, H; Itohara, S; Sakatani, S; Seto-Ohshima, A | 1 |
| Henry, M; Hescheler, J; Radhakrishnan, K; Schneider, T; Weiergräber, M | 1 |
| Boss-Williams, KA; Tabb, K; Weinshenker, D; Weiss, JM | 1 |
| Antonucci, F; Bozzi, Y; Caleo, M; Manno, I | 2 |
| Chancer, Z; Lorenzana, A; Schauwecker, PE | 1 |
| Hashizume, K; Hodozuka, A; Takebayashi, S; Tanaka, T | 1 |
| Akaike, K; Imamura, S; Kasugai, M; Matsukubo, H; Nakamura, M; Sano, A; Tanaka, S; Tojo, H | 1 |
| Glavan, G; Glisović, S; Saghafi, MM; Zivin, M | 1 |
| Cheng, IH; Gerstein, H; Mucke, L; Palop, JJ; Roberson, ED; Scearce-Levie, K; Wu, T; Yan, F; Yu, GQ | 1 |
| Anderson, C; Behanna, HA; Koh, S; Robin, B; Somera, CA; Somera-Molina, KC; Stine, C; Van Eldik, LJ; Wainwright, MS; Watterson, DM | 1 |
| Bahr, BA; Karanian, DA; Karim, SL; Lin, S; Makriyannis, A; Williams, JS; Wood, JT | 1 |
| Gray, WP; Howell, OW; Laskowski, A; McKhann, G; Sosunov, AA; Sosuov, AA | 1 |
| Bolognani, F; Nixon, S; Okano, H; Okano, HJ; Perrone-Bizzozero, NI; Tanner, DC | 1 |
| Beaudoin, ME; Fritz, MJ; Fulton, R; Liang, LP; Patel, M | 1 |
| Furuya, M; Hama, H; Kasuya, Y; Kimura, S; Kuwaki, T; Matsuo, Y; Mizuhashi, S; Nakamura, A; Namiki, K; Sudo, T; Tokuhara, N; Yano, S | 1 |
| Foradori, CD; Handa, RJ; Koenig, JI; Lund, TD; Nagahara, AH | 1 |
| Bellver-Estelles, C; Chu, X; Dicker, P; Dunleavy, M; Hatazaki, S; Henshall, D; Koegel, I; Meller, R; Murphy, B; Prehn, J; Schindler, C; Shinoda, S; Simon, R; Wang, W; Xiong, Z; Yamamoto, A | 1 |
| Clark, S; Dudek, FE; Grabenstatter, HL | 1 |
| Foti, S; Haberman, RP; McCown, TJ; Samulski, RJ | 1 |
| Clarkson, AN; Hesp, BR; Kerr, DS; Sawant, PM | 1 |
| Anderson, AE; Lubin, FD; Ren, Y; Xu, X | 1 |
| Clemenson, GD; Gage, FH; Jessberger, S; Li, Y; Toni, N; Zhao, C | 1 |
| Chung, JH; Kim, HJ; Park, HJ; Ra, J; Yim, SV; Zheng, LT | 1 |
| Ercan, F; Erkanli, G; Onat, F; Salik, E; San, T; Sirvanci, S; Yananli, HR | 1 |
| Lu, Y; Peng, L; Petralia, RS; Soundarapandian, MM; Tu, W; Wu, D; Zhong, X | 1 |
| Arkhipov, V; Kulesskaja, N; Lebedev, D | 1 |
| Galanopoulou, AS | 2 |
| Chaix, Y; Ferraro, TN; Lapouble, E; Martin, B | 1 |
| Dudek, FE; Hellier, JL; Staley, KJ; White, AM; Williams, PA | 1 |
| Carpentino, JE; Grabel, LB; Hartman, NW; Naegele, JR | 1 |
| Fessel, JP; Hou, H; Kmiec, M; Liang, LP; Patel, M; Roberts, LJ; Swartz, HM; Williams, BB | 1 |
| Rensing, NR; Rothman, SM; Sinatra, PM; Wong, M; Xu, L; Zeng, LH | 1 |
| Baram, TZ; Bender, RA; Brewster, AL; Richichi, C; Simeone, TA; Weiss, JH; Yin, HZ; Zha, Q | 1 |
| Blumberg, MS; Karlsson, KA; Mohns, EJ | 1 |
| Khan, FA; Lian, XY; Stringer, JL | 1 |
| Baram, TZ; Bender, RA; Brewster, AL; Richichi, C; Zha, Q | 1 |
| Barakos, J; Bargu, S; Colegrove, KM; Conrad, PA; Dennison, S; Goldstein, T; Gulland, FM; Haulena, M; Langlois, G; Leighfield, T; Mazet, JA; Silver, M; Van Dolah, F; Williams, DC; Zabka, TS | 1 |
| Bolkvadze, T; Kigyradze, T; Kiladze, M; Kuchiashvili, N; Nozadze, M; Pkhakadze, V; Solomonia, R; Zhvania, M | 1 |
| Holopainen, IE; Järvelä, JT; Lopez-Picon, FR | 1 |
| Akashiba, H; Matsuki, N; Nakayama, K; Nakayama, KI; Nishiyama, N; Ueyama, C | 1 |
| Jordan, WH; Miller, MA; Reams, RY; Sharma, AK; Snyder, PW; Thacker, HL | 1 |
| Chen, C; Lang, S; Liu, X; Xu, G; Zuo, P | 1 |
| Boison, D; Itohara, S; Iwasato, T; Lan, JQ; Li, T; Lusardi, T; Ren, G; Simon, RP; Wilz, A | 1 |
| Baik, EJ; Chung, JI; Jung, YS; Kim, HJ; Lee, SH; Moon, CH | 1 |
| Adem, A; Jin, T; Lu, MO; Mix, E; Quezada, HC; Zhang, XM; Zhu, J | 1 |
| Choi, ES; Jeong, SW; Kim, DW; Kwon, YS; Son, BK | 1 |
| Gmiro, VE; Serdyuk, SE | 1 |
| Han, JL; Jiang, W; Wang, JC; Yang, F; Zhao, G | 1 |
| Bing, G; Chae, JS; Jeong, JH; Jung, BD; Kim, HC; Kim, HJ; Kim, WK; Lee, SY; Park, ES; Shin, EJ; Wie, MB; Yen, TP | 1 |
| Behl, C; Clement, AB; Endres, K; Fahrenholz, F; Hanstein, R; Nagel, H; Schröder, A | 1 |
| Azzam, D; Dbaibo, G; El Dada, S; El Hokayem, J; El Sabban, M; Kobeissi, M; Koubeissi, M; Kurdi, R; Mikati, MA; Rahmeh, A; Rizk, E; Usta, J; Zeinieh, M | 1 |
| Cho, SH; Kang, SJ; Park, K; Shin, KS; Yi, J; Yoo, SJ | 1 |
| Einula, C; Gröhn, OH; Immonen, RJ; Kharatishvili, I; Pitkänen, A; Sierra, A | 1 |
| Behrens, CJ; Friedman, A; Gross, M; Heinemann, U; Ivens, S; Njunting, M; Soreq, H; Tolner, E; Tolner, EA; Zimmerman, G | 1 |
| Duan, RS; Mohammed, AH; Winblad, B; Zhang, XM; Zhu, J; Zhu, SW | 1 |
| Bosetti, F; Tomita, YA; Toscano, CD; Ueda, Y; Vicini, S | 1 |
| Bubb, V; Cosgrave, AS; McKay, JS; Morris, R; Quinn, JP; Thippeswamy, T | 1 |
| de Lecea, L; Hochgeschwender, U; Johnson, B; Qiu, C; Tallent, MK; Zeyda, T | 1 |
| Dudek, FE; Hellier, JL | 2 |
| Bloom, CS; Chancer, ZO; Lorenzana, A; McCord, MC; Schauwecker, PE | 1 |
| Henshall, DC; Murphy, N; Yamamoto, A | 1 |
| Fabel, K; Hörster, H; Kempermann, G; Steiner, B; Zurborg, S | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L | 2 |
| Cavalheiro, EA; Kleinrok, Z; Turski, L; Turski, WA | 1 |
| Lason, W; Przewlocka, B; Przewlocki, R; Stala, L | 1 |
| Donzanti, BA; Uretsky, NJ | 1 |
| Baran, H; Hornykiewicz, O; Kish, SJ; Lassmann, H; Seitelberger, F; Sperk, G | 1 |
| Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E | 1 |
| Keilhoff, G; Wolf, G | 1 |
| Costa, E; Gillin, JC; Hong, JS; Wood, PL; Yang, HY | 2 |
| Amato, G; Crescimanno, G; La Grutta, V; Sorbera, F | 2 |
| Cavalheiro, EA; Le Gal La Salle, G; Riche, DA | 1 |
| Cepeda, C; Comar, D; Crouzel, C; Menini, C; Mestelan, G; Naquet, R | 1 |
| Cavalheiro, EA; de Feo, MR; Mecarelli, O; Ricci, GF | 1 |
| Levin, SL; Sytinskiĭ, IA | 1 |
| Meldrum, BS; Menini, C; Riche, D; Silva-Comte, C; Stutzmann, JM | 1 |
| Collins, J; Coyle, JT; Slevin, J; Zaczek, R | 1 |
| Evenson, DA; Nadler, JV; Smith, EM | 1 |
| Besselièvre, R; Cepeda, C; Naquet, R; Potier, P; Rossier, J; Tanaka, T | 1 |
| Gale, K; Iadarola, MJ | 1 |
| Conboy, VT; Fuller, TA; Olney, JW | 1 |
| Czuczwar, SJ; Meldrum, B | 1 |
| Lancaster, B; Wheal, HV | 1 |
| Coyle, JT | 1 |
| Lothman, EW; Westbrook, GL | 1 |
| Ben-Ari, Y; Berger, M; Nitecka, L; Tremblay, E | 1 |
| Badman, G; Chapman, AG; Collins, JF; De Sarro, G; Dixon, AJ; Hart, GP; Meldrum, BS | 1 |
| Ben-Ari, Y; Cavalheiro, E; Tremblay, E | 1 |
| Ruth, RE | 2 |
| Brush, GS; Foster, AC; French, ED; Schwarcz, R | 1 |
| Evans, MC; Meldrum, BS | 1 |
| Albala, BJ; Moshé, SL; Okada, R | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W | 1 |
| Fuller, TA; Olney, JW | 2 |
| Clifford, DB; Dodson, WE; Ferrendelli, JA; Lothman, EW | 1 |
| Lothman, EW; Wooten, GF; Zucker, DK | 1 |
| McGeer, EG; McGeer, PL; Nagai, T | 1 |
| Calderazzo Filho, LS; Cavalheiro, EA; Feldblum, S; Le Gal la Salle, G; Riche, D | 1 |
| Ben-Ari, Y; Ottersen, OP; Rovira, C; Tremblay, E | 1 |
| Kessler, J; Markowitsch, HJ | 1 |
| Cherubini, E; de Feo, MR; Mecarelli, O; Ricci, GF | 2 |
| Cepeda, C; Hernandez, S; Martinez, A; Pacheco, MT | 1 |
| Olney, JW | 2 |
| Guldin, WO; Markowitsch, HJ | 1 |
| Sutherland, RJ; Whishaw, IQ | 1 |
| Coyle, JT; Zaczek, R | 1 |
| Collins, JF; De Gubareff, T; Olney, JW | 1 |
| Aldinio, C; French, ED; Schwarcz, R | 1 |
| Collins, RC; Ferrendelli, JA; Lothman, EW | 1 |
| Fariello, RG; Golden, GT; Pisa, M | 1 |
| Bernard, PS; Liebman, JM; Pastor, G; Saelens, JK | 1 |
| Coyle, JT; Nelson, M; Zaczek, R | 1 |
| Ben-Ari, Y; Ghilini, G; Naquet, R; Riche, D; Tremblay, E | 1 |
| Collins, RC; Lothman, EW | 1 |
| de Gubareff, T; Fuller, TA; Labruyere, J; Olney, JW | 1 |
| Smiałowska, M; Smiałowski, A | 1 |
| Daita, G; Kaijima, M; Ohgami, S; Tanaka, T; Yonemasu, Y | 1 |
| Jenner, P; Marsden, CD; Reavill, C; Taylor, RJ | 1 |
| Ben-Ari, Y; Meldrum, BS; Ottersen, OP; Tremblay, E | 1 |
| Fibiger, HC; Pisa, M; Sanberg, PR | 1 |
| Javid, MJ; Stone, WE | 1 |
| Coyle, JT; Nelson, MF; Zaczek, R | 1 |
| Fuller, T; Olney, JW; Price, JL; Schwob, JE | 1 |
| Collins, RC; de Gubareff, T; Fuller, TA; Olney, JW | 1 |
| Corcoran, ME; Fibiger, HC; Pisa, M; Sanberg, PR | 1 |
| Kaczmarek, L; Kamińska, B; Lasoń, W; Lukasiuk, K; Nowicka, DZ; Przewłocka, B; Przewłocki, R | 1 |
| Applegate, CD; Piekut, DT; Pretel, S | 1 |
| Sperk, G | 1 |
| Klitgaard, H; Laudrup, P | 2 |
| Ben-Ari, Y; Bugra, K; Charton, G; Khrestchatisky, M; Moreau, J; Pollard, H | 1 |
| Baran, L; Przegaliński, E; Siwanowicz, J | 1 |
| Hong, KS; Kaibuchi, K; Kim, YS; Kishi, K; Kuroda, S; Park, JB; Seong, YS; Takai, Y | 1 |
| Huston, JP; Klapdor, K; Sprick, U | 1 |
| Christakos, S; Devinsky, O; Howells, R; Lee, S; Lothman, E; Miskovsky, J; Williamson, J | 1 |
| Davis, W; Penix, LP; Subramaniam, S | 1 |
| Lees, GJ; Leong, W | 2 |
| Cuevas, P; Giménez-Gallego, G; Herreras, O; Largo, C; Revilla, C | 1 |
| Busse, R; Mordvintcev, PI; Mülsch, A; Nielsen, EO; Olesen, SP; Scheel-Krüger, J; Vanin, AF | 1 |
| Bagetta, G; Granato, T; Iannone, M; Nisticò, G; Palma, E; Rodinò, P | 1 |
| Barbier, P; Corsini, GU; Donati, E; Fumagalli, F; Maggio, R; Racagni, G; Riva, M | 1 |
| Blendy, JA; Gass, P; Kiessling, M; Schmid, W; Schütz, G | 1 |
| Martin, D; Miller, G; Rosendahl, M; Russell, DA | 1 |
| Baudry, M; Hayashi, Y | 1 |
| Fujita, T; Nakai, H; Takano, K; Tanaka, T; Yonemasu, Y | 1 |
| Amaral, DG; Gualandris, A; Strickland, S; Tsirka, SE | 1 |
| Domagala, W; Filipkowski, RK; Hetman, M; Kaczmarek, L | 1 |
| de Feo, MR; Mecarelli, O; Ricci, GF | 1 |
| Berg, M; Bruhn, T; Diemer, NH; Frandsen, A; Schousboe, A | 1 |
| Héron, A; Pinard, E; Rigaud-Monnet, AS; Seylaz, J | 1 |
| Berrettini, WH; Ferraro, TN; Golden, GT; Smith, GG | 1 |
| Civenni, G; Hoyer, D; Pérez, J; Rizzi, M; Schüpbach, E; Tutka, P; Vezzani, A | 1 |
| Baudry, M; Bruce, AJ | 1 |
| Dunham, L; Guillet, R | 1 |
| Folbergrová, J; Kubová, H; Mares, P | 1 |
| Dash, R; Ho, DY; Lawrence, MS; Sapolsky, RM | 1 |
| Brines, ML; Dare, AO; de Lanerolle, NC | 1 |
| Beck, KD; Day, JR; Dugich-Djordjevic, MM; Hefti, F; Mori, N; Ohsawa, F; Okazaki, T | 1 |
| Andrews, GK; Dalton, T; Pazdernik, TL; Samson, F; Wagner, J | 1 |
| Lang, S; Sperk, G | 1 |
| Lemaire, S; Shukla, VK | 1 |
| Babb, TL; Cifuentes, F; Leite, JP; Mathern, GW; Pretorius, JK | 1 |
| Donevan, SD; Rogawski, MA; Yamaguchi, S | 1 |
| Gramsbergen, JB; van den Berg, KJ | 1 |
| Guilhem, D; Junier, MP; Onteniente, B; Suzuki, F; Sørensen, JC | 1 |
| Gahring, LC; Rogers, SW; Spiess, J; Twyman, RE | 1 |
| Ahmad, I; Pleuvry, BJ | 1 |
| Collet, A; Lallement, G; Pont, F | 1 |
| Ferraro, TN; Golden, GT; Reyes, PF; Smith, GG | 1 |
| Gass, P; Kiessling, M; Prior, P | 1 |
| Ferrer, I; Planas, AM; Rodríguez Farré, E; Soriano, MA | 1 |
| Bandopadhyay, R; De Belleroche, J | 1 |
| Bonuccelli, U; Fariello, R; Garant, DS; Maggio, R | 1 |
| Civenni, G; Messali, S; Monno, A; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Simon, RP; Tanaka, K | 1 |
| Ben-Ari, Y; Niquet, J; Represa, A | 1 |
| Keith, LD; Roberts, AJ | 2 |
| Shimosaka, S; Simon, RP; So, YT | 1 |
| Filipkowski, RK; Kaczmarek, L; Kaminska, B; Lason, W; Przewlocki, R; Zurkowska, G | 1 |
| Little, HJ; Watson, WP | 1 |
| Bocchiaro, C; Curran, T; Kerppola, TK; Luk, D; Morgan, JI; Robertson, LM; Smeyne, RJ; Vendrell, M | 1 |
| Dugichi-Djordjevich, MM; Finch, CE; Johnson, SA; Morgan, TE; Pasinetti, GM; Rozovsky, I; Willoughby, DA | 1 |
| Greber, S; Gruber, B; Rupp, E; Sperk, G | 1 |
| Ferrer, I; Planas, AM; Rodríguez-Farré, E; Soriano, MA | 1 |
| Baudry, M; Ferguson, G; Herschman, HR; Lim, IK; Tocco, G; Vician, L | 1 |
| Bellmann, R; Krause, JE; McCarson, KE; Röder, C; Sperk, G | 1 |
| D'Hooge, R; De Deyn, PP; Pei, YQ | 1 |
| Ahmad, I; Lauretti, GR; Pleuvry, BJ | 1 |
| Hashizume, K; Tanaka, T; Yonemasu, Y | 2 |
| Baran, H; Löscher, W; Mevissen, M | 1 |
| Baudry, M; Kedes, L; Najm, I; Sakhi, S; Schreiber, SS; Sussman, MA; Tocco, G | 1 |
| Collaço-Moraes, Y; de Belleroche, JS | 1 |
| Lasoń, W; Przewłocki, R | 1 |
| Altagracia, M; Alvarado-Calvillo, R; Kravzov, J; Manjarrez-Marmolejo, J; Monroy-Noyola, A; Osorio-Rico, L; Ríos, C | 1 |
| Araki, T; Goto, I; Kato, M | 1 |
| Borredon, J; Pinard, E; Rigaud-Monnet, AS; Seylaz, J | 1 |
| Bendotti, C; Pende, M; Samanin, R | 1 |
| Aramnejad, E; Ceserani, R; Costa, G; Lanza, M; Pisani, A; Princi, P; Saija, A; Scalese, M | 1 |
| Pohle, W; Rauca, C | 1 |
| Baudry, M; Bruce, A; Sakhi, S; Schreiber, SS; Sun, N; Tocco, G | 1 |
| Kaczmarek, L; Kamińska, B; Lukasiuk, K | 1 |
| Bektesh, S; Collins, F; Hoffer, B; Humpel, C; Olson, L; Strömberg, I | 1 |
| Baran, H; Hornykiewicz, O; Lassmann, H; Vass, K | 1 |
| Cotman, CW; Gómez-Pinilla, F; Van Der Wal, EA | 1 |
| Chronopoulos, A; Gatt, A; Holmes, GL; Hyde, P; Liu, Z; Mikati, MA; Stafstrom, CE; Thurber, S; Werner, S | 1 |
| Baudry, M; Najm, I | 1 |
| Bravo, R; Gass, P; Herdegen, T; Kiessling, M | 1 |
| Dakshinamurti, K; Sharma, SK; Sundaram, M; Watanabe, T | 1 |
| Berg, M; Bruhn, T; Diemer, NH; Johansen, FF | 1 |
| Belknap, JK; Crabbe, JC; Merrill, CM | 1 |
| Araki, T; Fukui, M; Goto, Y; Kato, M | 1 |
| Cramer, CL; Knowles, MA; Palmer, GC; Stagnitto, ML | 1 |
| Blisard, KS; Fagin, K; Falivena, P; Harrington, DA; Olejniczak, P; Privitera, MD; Scremin, OU; Taylor, KL | 1 |
| Donati, E; Racagni, G; Riva, MA; Tascedda, F; Zolli, M | 1 |
| Barrere, B; Beloeil, JC; Berenger, G; Gillet, B; Meric, P; Peres, M; Seylaz, J | 1 |
| Dakshinamurti, K; Sharma, SK | 1 |
| Freund, TF; Magloczky, Z | 1 |
| Longo, FM; Lowenstein, DH; Seren, MS | 1 |
| Chen, J; Longo, FM; Massa, SM; Narasimhan, P; Sharp, FR; Wang, S; Zhang, JS | 1 |
| Fujita, T; Fukuda, H; Tanaka, T; Yamamoto, K; Yonemasu, Y | 1 |
| Kojima, T; Minatogawa, Y; Murashima, YL; Takazawa, A; Yamauchi, T; Yamazaki, O | 1 |
| Greber, S; Gruber, B; Sperk, G | 1 |
| Butman, M; Chen, J; Graham, SH; Haglid, KG; Longo, FM; Sharp, FR; Wang, S | 1 |
| D'Amore, PA; Gatt, A; Holmes, GL; Liu, Z; Mikati, M | 1 |
| Baudry, M; Najm, I; Schreiber, SS; Thompson, RF; Tocco, G | 1 |
| Douglass, J; Hong, JS; McMillian, MK; Pennypacker, KR | 1 |
| Haglid, KG; Hamberger, A; Wang, S; Yang, Q | 2 |
| Gatt, A; Holmes, GL; Liu, Z; Mikati, M | 1 |
| Chadi, G; Fuxe, K; Ganten, D; Humpel, C; Lippoldt, A; Olson, L | 1 |
| Fischer-Colbrie, R; Gruber, B; Mahata, M; Mahata, SK; Röder, C; Sperk, G | 1 |
| Birkle, DL | 1 |
| Biggio, G; Colombo, G; Concas, A; Cossu, A; Cuccheddu, T; Follesa, P; Sanna, E; Serra, M | 1 |
| Baudry, M; Najm, I; Schreiber, SS | 1 |
| Ben-Ari, Y; Ghilini, G; Khrestchatisky, M; Moreau, J; Pollard, H; Represa, A | 1 |
| Douglass, J; Fannin, R; Hong, JS; Mason, E; Pennypacker, KR; Thai, L; Walczak, D | 1 |
| De Sarro, A; De Sarro, G; Di Paola, ED; Vidal, MJ | 1 |
| Holmes, GL; Stafstrom, CE; Thompson, JL | 2 |
| Connor, JD; Nave, JM | 1 |
| Arai, T; Kimura, H; Mori, K; Nakao, S; Tooyama, I; Yasuhara, O | 1 |
| Finch, CE; Morgan, TE; Nichols, NR; Pasinetti, GM | 1 |
| Steppuhn, KG; Turski, L | 1 |
| Baudry, M; Najm, I; Schreiber, SS; Tocco, G | 1 |
| Chronopoulos, A; Holmes, GL; Hyde, PA; Mikati, MA; Stafstrom, CE; Thompson, JL; Thurber, SJ | 1 |
| Knowlton, B; Mintz, M; Myslobodsky, MS | 1 |
| Belluardo, N; Condorelli, DF; Dell'Albani, P; Funakoshi, H; Jiang, XH; Metsis, M; Mudò, G; Salin, T; Timmusk, T | 1 |
| Carmant, L; Holmes, GL; Liu, Z; Mikati, MA; Werner, SJ | 1 |
| Haglid, KG; Hamberger, A; Karlsson, JE; Wang, S; Yang, Q | 1 |
| Borlongan, CV; Sanberg, PR; Shytle, RD | 1 |
| Baran, H; Gramer, M; Hönack, D; Löscher, W | 1 |
| Kojima, T; Minatogawa, Y; Murashima, YL; Takazawa, A; Tanaka, K; Yamauchi, T | 1 |
| Hiraia, K; Hishinuma, F; Inokuchi, K; Inoue, M; Kato, A; Ozawa, F | 1 |
| De Strooper, B; Dewachter, I; Lorent, K; Moechars, D; Van Leuven, F | 1 |
| Araki, T; Kato, M; Kobayashi, T | 1 |
| Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J | 1 |
| Allen, NK; Arnold, MB; Bleisch, T; Borromeo, PS; Leander, JD; Lodge, D; Lugar, CW; Ornstein, PL; Schoepp, DD | 1 |
| Mehta, P; Sakhi, S; Schreiber, SS; Sun, N; Wing, LL | 1 |
| Phipps, B; Piekut, DT | 2 |
| Baldy-Moulinier, M; N'gouemo, P; Nguemby-Bina, C | 1 |
| Mitrovic, N; Nakic, M; Schachner, M; Sperk, G | 1 |
| Cuevas, P; Giménez-Gallego, G | 1 |
| Haas, KZ; Moshé, SL; Sperber, EF; Stanton, PK | 2 |
| Guo, Q; Kuang, P | 1 |
| Boulton, AA; Yu, PH; Zhang, X | 1 |
| D'Hooge, R; de Deyn, PP; Lebrun, P; Pei, YQ; Raes, A; van Bogaert, PP | 1 |
| Forbes, RA; Kirkby, RD; Subramaniam, S | 1 |
| Carroll, DM; Grossman, AB; Kirkby, RD; Subramaniam, S | 1 |
| Banerjee, PK; Chen, LS; Snead, OC; Wong, JG | 1 |
| Bazan, NG; Marcheselli, VL | 1 |
| Gobbi, M; Mennini, T; Röder, C; Schwarzer, C; Sperk, G; Vezzani, A | 1 |
| Bing, G; Bronstein, D; Hong, JS; Kim, HC; McMillian, MK; Pennypacker, KR | 1 |
| Baudry, M; Bi, X; Herschman, H; Lim, IK; Tocco, G; Vician, L | 1 |
| Czuczwar, SJ; Dzieciuch, J; Kleinrok, Z; Klonowski, P; Tutka, P | 1 |
| Halonen, T; Jolkkonen, E; Jolkkonen, J; Nissinen, J; Pitkänen, A | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Ferhat, L; Khrestchatisky, M; Represa, A | 1 |
| Gariboldi, M; Samanin, R; Tutka, P; Vezzani, A | 1 |
| Graham, SH; Simon, RP; Tanaka, K | 1 |
| Joo, JY; Kharlamov, A; Manev, H; Uz, T | 1 |
| Davidson, M; Matsumoto, I; Otsuki, M; Wilce, PA | 1 |
| Akarsu, ES; Ayhan, IH; Cağlar, S; Inan, LE; Kuli, P; Palaoğlu, O; Uysal, H | 1 |
| Drewes, LR; Gerhart, DZ; Gronlund, KM; Leino, RL; McCall, AL | 1 |
| Borredon, J; Montécot, C; Pinard, E; Seylaz, J | 1 |
| Bing, G; Bing, R; Feng, Z; Hong, JS; Hudson, P; Jin, L; Qi, Q; Wang, W; Zhang, W | 1 |
| Fuson, KS; May, PC; Ornstein, PL; Sacaan, AI; Salhoff, CR; Schoepp, DD; Tizzano, JP | 1 |
| Applegate, C; Phipps, B; Piekut, D; Pretel, S | 1 |
| Comair, YG; Hong, SC; Lüders, HO; Najm, IM; Ng, TC; Wang, Y | 1 |
| Holmes, GL; Liu, Z | 1 |
| Dash, R; Desai, A; Maecker, H; Rivier, J; Sapolsky, R; Vale, W | 1 |
| Pan, E; Stringer, JL | 1 |
| Baldessari, S; Bendotti, C; Guglielmetti, F; Pende, M; Samanin, R; Southgate, T | 1 |
| Ishida, M; Miyamoto, M; Shinozaki, H | 1 |
| Applegate, CD; Piekut, DT; Pretel, S; Sun, Q | 1 |
| Madhyastha, MS; Nijjar, MS | 1 |
| Bartolomei, F; Cau, P; Gastaldi, M; Massacrier, A; Planells, R; Robaglia-Schlupp, A | 1 |
| Gall, CM; Kornblum, HI; Sankar, R; Shin, DH; Wasterlain, CG | 1 |
| Shiraishi, K | 2 |
| Kamada, H; Konaka, R; Niwa, R; Ohya-Nishiguchi, H; Ueda, Y; Yokoyama, H | 1 |
| Holmes, GL; Hori, A; Liu, Z; Mikati, MA; Stafstrom, CE; Tandon, P | 1 |
| Bruhn, T; Christensen, T; Diemer, NH | 1 |
| Chan, PH; Epstein, CJ; Honkaniemi, J; Kondo, T; Mikawa, S; Sharp, FR | 1 |
| Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA | 1 |
| Armstrong, JN; Babity, JM; Currie, RW; Plumier, JC; Robertson, HA | 1 |
| Dürmüller, N; Graham, JL; Meldrum, BS; Sowinski, P | 1 |
| Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F | 1 |
| Appel, NM; Bell, JM; Freed, LM; O'Callaghan, JP; Rapoport, SI | 1 |
| Garcia, ML; Garcia, VB; Isackson, PJ; Murray, KD; Strehler, EE | 1 |
| Ben-Ari, Y; Canals, O; Khrestchatisky, M; Rivera, S; Timsit, S; Tremblay, E | 1 |
| Boulton, AA; Gelowitz, DL; Lai, CT; Yu, PH; Zhang, X | 1 |
| Aisen, PS; Freire-Moar, J; Pasinetti, GM; Sakhi, SH; Schreiber, SS; Tocco, G | 1 |
| Agarwal, KS; Dure, LS; Stringer, JL | 1 |
| Labuz, D; Lasón, W; Machelska, H; Przewłocka, B; Przewłocki, R; Turchan, J | 1 |
| Bing, G; Bronstein, D; Hong, JS; Kim, HC; Suh, HW; Wilson, B | 1 |
| Jolkkonen, E; Jolkkonen, J; Pitkänen, A | 1 |
| Labuz, D; Lasoń, W; Mika, J; Przewłocka, B; Przewłocki, R; Turchan, J | 1 |
| Bolwig, TG; Klemp, K; Larsen, PJ; Madsen, TM; Mikkelsen, JD; Woldbye, DP | 1 |
| Lyons, WE; Mamounas, LA; Smith, MA; Zhang, LX | 1 |
| Holmes, GL; Hori, A; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y | 2 |
| Dasheiff, RM; Sacks, DS | 3 |
| Im, DH; Jhoo, WK; Kim, C; Kim, HC; Wie, MB | 1 |
| Celio, MR; Haglid, KG; Hamberger, A; Wang, S; Yang, Q | 1 |
| Hirai, K; Inokuchi, K; Kato, A; Ozawa, F; Saitoh, Y | 1 |
| Fuchs, K; Schwarzer, C; Sieghart, W; Sperk, G; Tsunashima, K; Wanzenböck, C | 1 |
| Jolkkonen, J; Kähkönen, K; Pitkänen, A | 1 |
| Burnham, WM; Eubanks, JH; Francis, J; Jones, OT; Jugloff, DG; Mingo, NS; Wallace, MC | 1 |
| Sperber, EF | 1 |
| Baudry, M; Bi, X; Chen, J | 1 |
| Fu, W; Furukawa, K; Kwiatkowski, DJ; Li, Y; Mattson, MP; Witke, W | 1 |
| Ebstein, RP; Shoham, S | 1 |
| Davis, RJ; Flavell, RA; Kuan, CY; Rakic, P; Rincón, M; Whitmarsh, AJ; Yang, DD; Zheng, TS | 1 |
| Baraban, SC; Erickson, JC; Hollopeter, G; Palmiter, RD; Schwartzkroin, PA | 1 |
| Bartolomei, F; Cau, P; Gastaldi, M; Massacrier, A; Nicolas, S; Planells, R | 1 |
| Hamilton, SE; Hille, B; Idzerda, RL; Levey, AI; Loose, MD; McKnight, GS; Nathanson, NM; Qi, M | 1 |
| Bing, G; Feng, W; Feng, Z; Hong, JS; Hudson, P; Zhang, W | 1 |
| Baldessari, S; Bendotti, C; Butelli, E; Guglielmetti, F; Rattray, M; Samanin, R | 1 |
| Clayton, EC; Means, LW; Peng, YG; Ramsdell, JS | 1 |
| Haugvicová, R; Koryntová, H; Langmeier, M; Mares, P; Slapal, R | 1 |
| Fischer-Colbrie, R; Schwarzer, C; Sperk, G; Tsunashima, K; Wolkersdorfer, M | 1 |
| Flores-Murrieta, FJ; Garcia-Arenas, G; Rios, C | 1 |
| Gass, P; Herdegen, T; Hsieh, TF; Marescaux, C; Simler, S; Vergnes, M; Wiegand, SJ; Zimmermann, M | 1 |
| Belluardo, N; Metsis, M; Palm, K; Timmusk, T | 1 |
| Hughes, J; Panegyres, PK | 1 |
| Hiscock, JJ; Mackenzie, L; Medvedev, A; Willoughby, JO | 2 |
| Cheng, HW; Isackson, PJ; McNeill, TH; Murray, KD; Salton, SR; Snyder, SE | 1 |
| Oganesian, GA; Titkov, ES; Vataev, SI | 1 |
| Acheson, A; Anderson, K; Cai, N; Corcoran, T; Lindsay, RM; Mather, PE; Pasnikowski, EM; Rudge, JS; Wiegand, SJ | 1 |
| Husum, H; Mikkelsen, JD; Mørk, A | 1 |
| Serratosa, J; Solà, C; Tusell, JM | 1 |
| Labuz, D; Mika, J; Przewłocka, B; Przewłocki, R; Ziółkowska, B | 1 |
| Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV | 1 |
| Comair, YG; Lüders, HO; Najm, IM; Ng, TC; Shedid, D; Wang, Y | 1 |
| Montécot, C; Pinard, E; Rondi-Reig, L; Seylaz, J; Springhetti, V | 1 |
| Bettler, B; Bureau, I; Castillo, PE; Dickinson-Anson, H; Gage, FH; Heinemann, SF; Mann, JR; Maron, C; Mulle, C; Pérez-Otaño, I; Sailer, A | 1 |
| Biedermann, IW; Dabrowski, M; Filipkowski, RK; Gorecki, DC; Hetman, M; Kaczmarek, L; Kaminska, B; Konopka, D; Lukasiuk, K; Nowicka, D; Szklarczyk, AW | 1 |
| Czuczwar, SJ; Kleinrok, Z; Pilip, S; Turski, WA; Urbanska, EM | 1 |
| Holmes, GL; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y | 1 |
| Lozada, A; Mathern, GW; Mendoza, D; Pretorius, JK; Price, G; Rosales, C | 1 |
| Holmes, GL; Liu, Z; Schachter, SC; Schomer, DL; Silveira, DC | 1 |
| Hayakawa, T; Kohmura, E; Nonaka, M; Shimada, S; Tanaka, K; Tohyama, M; Yamashita, T; Yoshimine, T | 1 |
| Cuajungco, MP; Lees, GJ; Leong, W | 1 |
| Cau, P; Gastaldi, M; Massacrier, A; Planells, R; Robaglia-Schlupp, A | 1 |
| Layton, ME; Pazdernik, TL; Samson, FE | 1 |
| Asada, H; Ding, R; Obata, K | 1 |
| Lu, YF; Matsui, H; Moriwaki, A; Tomizawa, K | 1 |
| Buckmaster, PS; Dudek, FE; Hellier, JL; Patrylo, PR | 1 |
| Dernovsek, MZ; Sket, D | 1 |
| Baudry, M; Crispino, M; Feldman, JD; Herschman, HR; Tocco, G; Vician, L | 1 |
| Baudry, M; Standley, S | 1 |
| Henshall, DC; Shimosaka, S; Simon, RP; Tanaka, K; Waga, S | 1 |
| Koryntová, H; Mares, P | 1 |
| Head, E; Holsinger, RM; Ikeda-Douglas, CJ; Milgram, NW; Racine, R; Tremblay, L | 1 |
| Ebert, U; Koch, M | 1 |
| Kamada, H; Ohya-Nishiguchi, H; Ueda, Y; Yokoyama, H | 1 |
| Becker, A; Braun, H; Höllt, V; Schröder, H; Schulz, S | 1 |
| Hashizume, K; Maeda, T; Sako, K; Tanaka, T | 1 |
| Eriksson, KS; Fukui, H; Karlstedt, K; Lintunen, M; Panula, P; Sallmen, T | 1 |
| Hashimoto, K; Iyo, M; Minabe, Y; Nishimura, T; Shirayama, Y; Watanabe, K | 1 |
| Brené, S; Lindefors, N; Zachrisson, O | 1 |
| Kandlhofer, S; Schwarzer, C; Sperk, G; Tsunashima, K | 1 |
| Longo, BM; Mello, LE | 1 |
| Becker, HC; Diaz-Granados, JL; Veatch, LM | 1 |
| Corriveau, RA; Huh, GS; Shatz, CJ | 1 |
| Bayon, LE; Frye, CA | 3 |
| Baram, TZ; Brunson, KL; Schultz, L | 1 |
| Babb, T; Baudry, M; Ckakraverty, D; Hadam, J; Lüders, HO; Markarian, G; Mikuni, N; Najm, IM; Penrod, C; Sopa, C | 1 |
| Balestra, M; Borrelli, AR; Cramer, CL; Eismann, MS; Freedman, LR; Hudzik, TJ; Knowles, MK; Mahmood, N; McCarthy, DJ; Murray, RJ; Palmer, GC; Stagnitto, ML | 1 |
| Lang, MK; Walz, W | 1 |
| Damm, D; Mark, RJ; Mattson, MP; Opanashuk, LA; Porter, J; Seroogy, KB | 1 |
| Kashihara, K; Marui, K; Sakai, K; Shohmori, T | 1 |
| Arkinstall, S; Boschert, U; Camps, M; Dickinson, R; Muda, M | 1 |
| Bragin, A; Engel, J; Fried, I; Mathern, GW; Wilson, CL | 1 |
| Behrens, A; Sibilia, M; Wagner, EF | 1 |
| Hashizume, K; Maeda, T; Tanaka, T | 1 |
| Endo, A; Hashimoto, K; Nagai, N; Takada, A; Takada, Y; Urano, T | 1 |
| Bouilleret, V; Depaulis, A; Le Gal La Salle, G; Marescaux, C; Nehlig, A; Ridoux, V | 1 |
| Dragunow, M; During, MJ; Lawlor, PA; Leone, P; Young, D | 1 |
| Aguzzi, A; Leist, M; Li, ZW; Müller, U; Nicotera, P; Steinbach, JP | 1 |
| Bregola, G; Candeletti, S; Romualdi, P; Simonato, M | 1 |
| Mackenzie, L; Willoughby, JO | 1 |
| Datson, N; de Jong, J; de Kloet, ER; Engels, B; Schaaf, M; van Koningsbruggen, S; Vreugdenhil, E | 1 |
| Hong, SH; Kim, YH; Koh, JY; Park, JH | 1 |
| Babb, TL; Chakravarty, DN; Christi, W; Mikuni, N | 1 |
| Dawson, R; Eppler, B; Millard, WJ; Patterson, TA; Zhou, W | 1 |
| Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F | 1 |
| Binder, DK; McNamara, JO; Routbort, MJ | 1 |
| Brecht, S; Dorst, A; Herdegen, T; Mielke, K | 1 |
| Medvedev, A; Willoughby, JO | 1 |
| Holmes, GL; Liu, Z; Muller-Schwarze, AB; Stafstrom, CE; Tandon, P; Yang, Y | 1 |
| Faherty, CJ; Smeyne, RJ; Xanthoudakis, S | 1 |
| Ito, H; Kamei, K; Kato, K; Katoh-Semba, R; Takeuchi, IK | 1 |
| Hoshika, A; Miyajima, T; Ohyu, J; Takami, T; Takashima, S; Takei, Y | 1 |
| Fujinaka, T; Hayakawa, T; Kohmura, E; Nonaka, M; Tohyama, M; Yamashita, T; Yamauchi, A; Yoshimine, T | 1 |
| Górecki, DC; Kaczmarek, L; Lukasiuk, K; Simons, JP; Szklarczyk, A | 1 |
| Budziszewska, B; Jaworska-Feil, L; Lasoń, W; Leśkiewicz, M; Przewłocka, B; Turchan, J | 1 |
| Chen, MF; Hsieh, CL; Hsieh, CT; Li, SC; Li, TC; Lin, JG; Pon, CZ; Tang, NY | 1 |
| Bolwig, TG; Madsen, TM; Mikkelsen, JD; Woldbye, DP | 1 |
| Aisen, PS; Borelli, CB; Freire-Moar, J; Ho, L; Kelley, KA; Pasinetti, GM; Winger, D | 1 |
| Cole, AJ; Koh, S; Mian, AY; Santos, TC; Storey, TW | 1 |
| Henshall, DC; Simon, RP; Sinclair, J | 1 |
| Dickinson-Anson, H; Dyck, RH; Gage, FH; Heinemann, SF; Malkmus, SA; Maron, C; O'Gorman, S; O'Leary, L; Pérez-Otaño, I; Sailer, A; Schiffer, HH; Swanson, GT; Yaksh, TL | 1 |
| Armstrong, JN; Currie, RW; Krueger, AM; Plumier, J; Robertson, HA | 1 |
| Calbet, M; de Lecea, L; Guadaño-Ferraz, A; Maj, M; Przewłocki, R; Spier, AD; Sutcliffe, JG | 1 |
| Bengzon, J; Hansson, SR; Hoffman, BJ; Lindvall, O | 1 |
| Baik, EJ; Kim, EJ; Lee, SH; Moon, C | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M | 1 |
| Inaguma, Y; Ito, H; Kato, K; Katoh-Semba, R; Takeuchi, IK | 1 |
| Baraban, SC; Hollopeter, G; Marsh, DJ; Palmiter, RD | 1 |
| Holmes, GL; Schmid, R; Stafstrom, CE; Tandon, P | 1 |
| Bausch, SB; McNamara, JO; Routbort, MJ | 1 |
| Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS | 1 |
| Amaral, OB; Brentani, RR; Cavalheiro, EA; Izquierdo, I; Martins, VR; Rockenbach, IC; Roesler, R; Walz, R | 1 |
| Chen, J; Henshall, DC; Lan, J; Simon, RP | 1 |
| Dettbarn, WD; Milatovic, D; Zivin, M | 1 |
| Slamberová, R; Vathy, I; Velísek, L | 1 |
| Chan, SL; Christakos, S; Gary, DS; Mattson, MP; Sooy, K | 1 |
| Ramirez, JJ; Schauwecker, PE; Steward, O | 1 |
| Kim, CG; Kim, DH; Kim, YH; Koh, JY; Lee, JY; Park, J | 1 |
| Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M | 1 |
| Han, SH; Lee, KW; Lee, SH | 1 |
| Bugge, TH; Degen, JL; Frohman, MA; Levine, JM; Lu, W; Margolis, RU; Milev, P; Siao, CJ; Sung, TC; Tsirka, SE; Wu, YP | 1 |
| Conti, M; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Beck, H; Becker, AJ; Blümcke, I; Elger, C; Emson, P; Friedl, MG; Klein, C; Kuhn, R; Lie, AA; Scheiwe, C; Waha, A; Wiestler, OD | 1 |
| Bac, P; Delcourt, P; Herrenknecht, C; Maurois, P; Stables, JP; Vamecq, J | 1 |
| Ben-Ari, Y; Congar, P; Crépel, V; Gaïarsa, JL; Popovici, T | 1 |
| Cole, TB; Palmiter, RD; Robbins, CA; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Angelatou, F; Ekonomou, A; Kostopoulos, G; Sperk, G | 1 |
| Hashizume, K; Kunimoto, M; Maeda, T; Tanaka, T | 1 |
| Bouilleret, V; Celio, MR; Fritschy, JM; Schurmans, S; Schwaller, B | 1 |
| Blondeau, N; Heurteaux, C; Lauritzen, I; Lazdunski, M; Romey, G; Widmann, C | 1 |
| Leavens, W; Morton, AJ | 1 |
| Baudry, M; Crispino, M; Feldman, JD; Herschman, HR; Hoe, W; Vician, L | 2 |
| Woolley, CS | 1 |
| Cole, TB; Koh, JY; Lee, JY; Palmiter, RD | 1 |
| Wang, L; Wu, XR; Zhao, DY; Zuo, CH | 1 |
| Bouilleret, V; Marescaux, C; Namer, IJ; Nehlig, A | 1 |
| Dean, RG; DePrato Primeaux, S; Edwards, GL; Holmes, PV; Martin, RJ | 1 |
| Stringer, JL; Xiong, ZQ | 1 |
| de Kloet, ER; Grootendorst, J; Haasdijk, E; Jaarsma, D; Mulder, M | 1 |
| Cai, B; Fujikawa, DG; Shinmei, SS | 1 |
| Hannibal, J; Matsumoto, T; Nomura, M; Serino, R; Shibuya, I; Ueta, Y; Yamamoto, Y; Yamashita, H | 1 |
| Emerson, MR; Pazdernik, TL; Samson, FE | 1 |
| Abe, K; Akiyama, K; Kashihara, K; Kodama, M; Kohira, I | 1 |
| Mattson, MP | 1 |
| Mack, KJ; Nanda, SA | 1 |
| Robbins, CA; Schwartzkroin, PA; Wenzel, HJ; Woolley, CS | 1 |
| Cantallops, I; Routtenberg, A | 1 |
| Ho, DY; Ho, JJ; Ozawa, CR; Sapolsky, RM; Tsai, DJ | 1 |
| Jimbo, Y; Robinson, HP | 1 |
| Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT | 1 |
| Mamelak, AN; Najbauer, J; Schuman, EM | 1 |
| Bownds, J; Janumpalli, S; Lynch, M; Sayin, U; Sutula, T | 1 |
| Carrasco, J; Hadberg, H; Hidalgo, J; Molinero, A; Penkowa, M | 1 |
| Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M | 1 |
| Lev, S; Litvak, V; Tian, D | 1 |
| Jazvinsćak, M; Mirković, K; Pericić, D; Svob, D | 1 |
| Agui, K; Anzai, K; Kamo, S; Kobayashi, S; Li, Y; Ohmae, A | 1 |
| Fan, XD; Juorio, AV; Li, XM | 1 |
| Agnello, D; Brines, ML; Cerami, A; Cerami, C; de Lanerolle, NC; Ghezzi, P; Itri, LM; Keenan, S | 1 |
| Abrahám, G; Andrási, F; Berzsenyi, P; Csuzdi, E; Hámori, T; Hársing, LG; Horváth, G; Horváth, K; Kapus, G; Király, I; Ling, I; Pallagi, I; Patthy, M; Sólyom, S; Tarnawa, I | 1 |
| Hoertnagl, B; Kartarova, Z; Somogyi, R; Sperk, G; Szabó, G | 1 |
| Kim, CY; Lee, SR; Lee, YK | 1 |
| Aoyama, M; Itoh, O; Kamada, H; Obara, H; Ohya, H; Yokoyama, H | 1 |
| Custodio, D; Hallak, M; Hotra, JW; Kruger, ML | 1 |
| Mack, KJ; Todd, PK | 1 |
| Lenox, RH; McNamara, RK | 1 |
| Ayala-Guerrero, F; González, V; González-Maciel, A; Huerta, B; Reynoso-Robles, R; Romero, RM; Vargas, L | 1 |
| Ajilore, O; Dumas, T; Gupta, A; Ho, D; Hsieh, J; Lawrence, M; McGaugh, JL; McLaughlin, J; Roozendaal, B; Sapolsky, R | 1 |
| Borrelli, E; Bozzi, Y; Vallone, D | 1 |
| Ben-Ari, Y; Cossart, R | 1 |
| Bolanos, AR; Cilio, MR; Holmes, GL; Liu, Z; Mikati, MA; Schmid, R; Stafstrom, CE; Yang, Y | 1 |
| Deb, S; Gottschall, PE; Zhang, JW | 1 |
| Ho, YS; Liang, LP; Patel, M | 1 |
| Aihara, N; Asai, K; Fujita, M; Kato, T; Tada, T; Ueki, T; Yamada, K; Yamamoto, M | 1 |
| Fenster, RJ; McEwen, BS; Pavlides, C; Sarnyai, Z; Sibille, EL; Toth, M | 1 |
| Budziszewska, B; Jaworska-Feil, L; Kajta, M; Lasoń, W; Leśkiewicz, M | 1 |
| Cilio, MR; Holmes, GL; Silveira, D; Silveira, DC; Sogawa, Y; Stafstrom, CE; Su, SW | 1 |
| Ahn, H; Huh, Y; Kang, K; Kang, M; Kim, J; Lee, J; Park, C; Yoo, J | 1 |
| Doi, T; Kamada, H; Mitsuyama, Y; Nakajima, A; Ohya-Nishiguchi, H; Tokumaru, J; Ueda, Y; Willmore, LJ; Yokoyama, H | 1 |
| Slamberová, R; Vathy, I | 1 |
| Berrettini, WH; Ferraro, TN; Golden, GT; Jones, NL; Smith, GG; Snyder, RL | 1 |
| Kunz, T; Oliw, EH | 2 |
| Christie, BR; Collins, AC; Ghetti, A; Heinemann, SF; O'Gorman, S; Perez-Otano, I; Radcliffe, RA; Royle, GA; Schiffer, HH; Seamans, J; Sejnowski, T; Tritto, T; Vissel, B; Wehner, JM | 1 |
| Jhoo, WK; Kang, KS; Kim, HC; Kim, WK; Ko, KH; Shin, CY; Shin, EJ | 1 |
| Carrasco, J; Hidalgo, J; Molinero, A; Penkowa, M | 1 |
| Lerma, J | 1 |
| Bae, CD; Jeon, SH; Kim, YS; Park, JB | 1 |
| Guan, Z; Hong, J; Liu, J; Liu, X; Lu, L; Lü, S; Xin, Y; Yu, F; Zhang, W; Zheng, Z | 1 |
| Bourne, JA; Fosbraey, P; Halliday, J | 1 |
| Boeckers, TM; de la Cerda, A; Grimm, R; Gundelfinger, ED; Marengo, JJ; Orrego, F; Smalla, KH; Soto, D; Tischmeyer, W; Wolf, G; Wyneken, U | 1 |
| Arima, H; Basile, AS; Fedorova, I; Fernandez, AM; Hernández-Sánchez, C; Ito, Y; LeRoith, D; Stannard, B | 1 |
| Kitayama, T; Ogita, K; Okuda, H; Yoneda, Y | 1 |
| Camandola, S; Chan, SL; Culmsee, C; Greig, NH; Guo, Z; Mattson, MP; Yu, QS; Zhu, X | 1 |
| Taniwaki, Y | 1 |
| Fei, J; Guo, LH; Hu, JH; Ma, Y; Mei, ZT; Yu, Y; Zhao, WJ; Zhou, XG | 1 |
| Akaike, K; Fukumoto, S; Imamura, S; Takigawa, M; Tanaka, S; Tojo, H | 2 |
| Barrón, S; Serratosa, J; Solà, C; Tusell, JM | 1 |
| Bonislawski, DP; Henshall, DC; Lan, JQ; Simon, RP; Skradski, SL | 1 |
| Ishii, N; Kimura, Y; Kondo, H; Miura, S; Miyazaki, JI; Murata, K; Nose, M; Sakagami, H; Sasaki, H; Sugamura, K; Takeshita, T; Tashiro, F; Yamada, M | 1 |
| Ballerini, P; Ciccarelli, R; Di Iorio, P; Giuliani, P; Middlemiss, PJ; Rathbone, MP; Vianale, G; Virgilio, A | 1 |
| Brines, ML; Cerami, A; Cerami, CJ; Ghezzi, P | 1 |
| Henshall, DC; Lan, JQ; Ren, T; Simon, RP; Skradski, SL | 1 |
| Budziszewska, B; Jaworska-Feil, L; Kajta, M; Kubera, M; Lasoń, W; Leśkiewicz, M | 1 |
| Cairasco, NG; dos Santos, WF; Guizzo, R; Rodrigues, MC | 1 |
| Levid, J; Schreiber, SS; Tan, Z | 1 |
| Agarwala, A; Lee, H; Wen Lou, D; Xu, M; Zhang, J | 1 |
| Cheon, MA; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Shin, CY; Shin, EJ | 1 |
| Ben-Ari, Y | 2 |
| Che, Y; Han, PL; Lee, JK; Piao, CS | 1 |
| Davies, B; Davies, CH; Kearns, IR; Lathe, R; Ure, J | 1 |
| Jensen, FE; Koh, S | 1 |
| Hohmann, JG; Miller, NS; Palmiter, RD; Pyati, U; Rust, NC; Szot, P; Weinshenker, D; White, SS | 1 |
| Akbar, MT; de Belleroche, J; Latchman, DS; Wells, DJ | 1 |
| Ananth, C; Gopalakrishnakone, P; Kaur, C; Thameem Dheen, S | 1 |
| Gurd, JW; Ikeda-Douglas, CJ; Milgram, NW; Moussa, RC; Thakur, V | 1 |
| Liang, LP; Patel, M; Roberts, LJ | 1 |
| Aronow, BJ; Lu, A; Sharp, FR; Tang, Y | 1 |
| Gmiro, VE; Gorbunova, LV; Lukomskaia, NIa; Rukoiatkina, NI | 1 |
| Ayala-Guerrero, F; González-Maciel, A; Reynoso-Robles, R; Romero, RM; Vargas, L | 1 |
| Haas, KZ; Moshé, SL; Opanashuk, LA; Sperber, EF; Stanton, PK | 1 |
| Kaczmarek, L; Lapinska, J; McKay, RD; Rylski, M; Szklarczyk, A | 1 |
| Bing, G; Choi, YS; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, DW; Park, ES; Ryu, JR; Shin, CY; Shin, EJ | 1 |
| Cartier, L; Infante, C; Motles, E | 1 |
| Bogdanovic, N; Chen, Z; Ljunggren, HG; Nennesmo, I; Winblad, B; Zhu, J | 1 |
| Gavish, M; Leschiner, S; Spanier, I; Veenman, L; Weisinger, G; Weizman, A | 1 |
| Hoshika, A; Kumada, A; Miyajima, T; Tachibana, M; Takami, T; Takashima, S; Takei, Y | 1 |
| Bugge, TH; Coleman, TA; Lawrence, DA; Mitola, D; Moore, E; Sandkvist, M; Wu, JY; Yepes, M | 1 |
| Aono, S; Kawashima, S; Keino, H; Matsui, F; Oohira, A; Shuo, T; Tokita, Y; Yamauchi, S | 1 |
| Ben-Ari, Y; Lagowska, J | 1 |
| Ben-Ari, Y; Ottersen, OP; Tremblay, E | 1 |
| Ben-Ari, Y; Naquet, R; Ottersen, OP; Tremblay, E | 1 |
| Ben-Ari, Y; Lagowska, J; Le Gal La Salle, G; Tremblay, E | 1 |
| Freed, WJ; Michaelis, EK | 1 |
| Cotman, CW; Nadler, JV; Perry, BW | 1 |
| Bellmann, R; Krause, JE; Marksteiner, J; Ortler, M; Sperk, G; Wahler, R | 1 |
| Ackermann, RF; Haas, K; Moshé, SL; Sperber, EF; Stanton, PK | 1 |
| Baudry, M; Finch, CE; Johnson, SA; Najm, I; Pasinetti, GM; Tocco, G; Willoughby, DA | 1 |
| Aaron, CS; Camacho Ochoa, M; Jackson, TA; Lahti, RA; Strain, GM; Von Voigtlander, PF | 1 |
| Baudry, M; el-Skaf, G; Lynch, G; Najm, I; Tocco, G; Vanderklish, P | 1 |
| D'Mello, SR; Heinrich, G; Jiang, C; Lamberti, C; Martin, SC | 1 |
| Bellmann, R; Gruber, B; Mahata, M; Marksteiner, J; Ortler, M; Sperk, G | 1 |
| Berg, M; Bruhn, T; Cobo, M; Diemer, NH | 1 |
| Baudry, M; Fitzpatrick, JS; Shahi, K | 1 |
| Baram, TZ; Gomez, I; Hirsch, E; Snead, OC; Vergnes, M | 1 |
| Ackerman, RF; Lear, JL | 1 |
| Takano, K; Tanaka, T; Yonemasu, Y | 1 |
| Cavazos, J; Golarai, G; Sutula, T | 1 |
| Lasoń, W; Przewłocka, B; Przewłocki, R | 2 |
| Czurkó, A; Hajnal, A; Jandó, G; Karádi, Z; Lénárd, L; Sándor, P; Vida, I | 1 |
| Dudek, FE; Meier, CL; Obenaus, A | 1 |
| Araki, T; Goto, I; Kato, M; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Elliott, EM; Miller, CA; Newcombe, R; Sapolsky, RM; Schilling, JW; Stein-Behrens, BA | 1 |
| Mathis, C; Ungerer, A | 1 |
| Baudry, M; el-Skaf, G; Lynch, G; Massicotte, G; Najm, I; Vanderklish, P | 1 |
| Baudry, M; Dugich-Djordjevic, MM; Hefti, F; Lapchak, PA; Najm, I; Pasinetti, G; Thompson, RF; Tocco, G; Willoughby, DA | 1 |
| Bishai, A; Burnham, WM; Hwang, PA; Levy, SL | 1 |
| Baudry, M; Finch, CE; Johnson, SA; Najm, I; Schreiber, SS; Tocco, G | 1 |
| Costa, G; De Pasquale, R; Massi, M; Pisani, A; Princi, P; Saija, A; Santoro, G | 1 |
| Baudry, M; Dugich-Djordjevic, MM; Hefti, F; Lapchak, PA; Najm, I; Pasinetti, GM; Tocco, G | 1 |
| Gale, K; Maggio, R; Sohn, E | 1 |
| Garyaev, AP; Piotrovsky, LB; Poznyakova, LN | 1 |
| al-Tajir, G; Starr, MS | 1 |
| Humpel, C; Marksteiner, J; Saria, A; Sperk, G | 2 |
| Gall, C; Isackson, PJ; Murray, K | 1 |
| Araki, T; Kato, M; Tegoshi, S | 1 |
| Fariello, RG; Ferraro, TN; Golden, GT; Kulp, JK; Reyes, PF; Smith, GG | 1 |
| Carl, GF; Holmes, C; Holmes, GL; Huh, K; Thompson, JL | 1 |
| Lok, SY; Meldrum, BS; Millan, MH; Obrenovitch, TP; Sarna, GS; Symon, L | 1 |
| Moyanova, S; Riche, D | 1 |
| Arnold, MB; Elzey, T; Leander, JD; Lodge, D; Ornstein, PL; Paschal, JW; Schoepp, DD | 1 |
| Rizzi, M; Samanin, R; Serafini, R; Stasi, MA; Vezzani, A; Viganò, G | 1 |
| Kaplan, SM; Nash, DR; Norman, AB; Sanberg, PR | 1 |
| Abicht, K; Fischer, S; Hass, P; Keilhoff, G; Wolf, G | 1 |
| Jope, RS; Ormandy, GC; Song, L | 1 |
| Douglass, J; Grimes, L; Hong, JS; Lee, PH; Shook, J | 1 |
| Bellmann, R; Humpel, C; Krause, JE; Marksteiner, J; Saria, A; Sperk, G | 1 |
| Fujii, T; Hata, M | 1 |
| Dakshinamurti, K; Sharma, SK; Sundaram, M | 1 |
| Aizawa, H; Ishida, M; Kwak, S; Shinozaki, H | 1 |
| Ivy, GO; Khurgel, M; Milgram, NW; Racine, R; Yearwood, T | 1 |
| Calder, LD; Karler, R; Turkanis, SA | 2 |
| Jope, RS; Ormandy, GC | 1 |
| Bellmann, R; Humpel, C; Marksteiner, J; Saria, A; Sperk, G | 1 |
| De Sarro, A; De Sarro, GB; Donato Di Paola, E; Vidal, MJ | 1 |
| Sapolsky, RM; Tombaugh, GC | 1 |
| Carpenter, S; Cashman, NR; Evans, AC; Gendron, D; Gjedde, A; Teitelbaum, JS; Zatorre, RJ | 1 |
| Marksteiner, J; Prommegger, R; Sperk, G | 1 |
| Arias, C; Montiel, T; Tapia, R | 1 |
| Bellmann, R; Maas, D; Marksteiner, J; Meyer, DK; Olenik, C; Sperk, G; Widmann, R | 1 |
| Schwarcz, R; Turski, WA; Ungerstedt, U; Wu, HQ | 1 |
| Artigas, F; de Vera, N; Martínez, E; Serratosa, J | 1 |
| Maheshwari, MC; Selvamurthy, W; Sharma, SK; Singh, TP | 1 |
| Braun, DE; Freed, WJ | 1 |
| Brown, IR | 1 |
| Niemann, W; Stephens, DN; Turski, L | 1 |
| Kreider, MS; Winokur, A; Wolfinger, BL | 1 |
| Le Gal La Salle, G; Naquet, R | 1 |
| Amano, S; Hazama, F; Kashiro, N; Obata, T; Shimada, M | 1 |
| Nishihara, I; Sako, K; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Araki, T; Fukuda, H; Tanaka, S; Tanaka, T; Yomemasu, Y | 1 |
| Barbin, G; Beaudoin, M; Ben-Ari, Y; Crépel, V; Popovici, T; Represa, A | 1 |
| Hornykiewicz, O; Lassmann, H; Seitelberger, F | 1 |
| De Barry, J; Mathis, C; Ungerer, A | 1 |
| Colpaert, FC; Koek, W | 1 |
| Barnes, MI; Grimes, LM; Mitchell, CL | 1 |
| Himi, T; Kawai, N; Nakajima, T; Saito, H | 1 |
| Kumashiro, H; Kurokouchi, A; Mori, N; Tojo, Y | 1 |
| Churchill, L; Cross, RS; Nelson, SR; Pazdernik, TL; Samson, FE | 1 |
| Gale, K; Graham, J; Wardas, J | 1 |
| Beal, MF; Vécsei, L | 1 |
| Pinard, E; Puiroud, S; Riche, D; Seylaz, J | 1 |
| Earnhardt, TS; Grimes, LM; Hong, JS; Mitchell, CL; Tilson, HA | 1 |
| Simmet, T; Tippler, B | 1 |
| Franklin, PH; Murray, TF; Zhang, G | 2 |
| Kulkarni, SK; Mehta, AK; Ticku, MK | 1 |
| Cepeda, C; Kaijima, M; Tanaka, T; Yonemasu, Y | 1 |
| Singer, EA; Sperk, G; Widmann, R; Wieser, R | 1 |
| Kaijima, M; Kunimoto, M; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Kubová, H; Mares, P; Ortová, M; Velísek, L; Velísková, J | 1 |
| Lason, W; McGinty, JF; Simpson, JN | 2 |
| Rothe, T; Schliebs, R; Steinbach, J; Zivin, M | 1 |
| Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL | 1 |
| Gotoh, Y; Ishida, M; Kwak, S; Shinozaki, H | 1 |
| Marksteiner, J; Meyer, DK; Olenik, C; Sperk, G | 1 |
| Carl, GF; Critchfield, JW; Gallagher, BB; Holmes, GL; Hurley, LS; Keen, CL; McGinnis, LS; Thompson, JL; Wheeler, GA | 1 |
| Kulhánková, I; Mares, P; Mirvaldová, H; Roztocilová, L; Velísek, L; Velísková, J | 1 |
| Amado, D; Cavalheiro, EA; Cavanal, MF; Costa-Silva, VL; Gil, FZ | 1 |
| Kubová, H; Mares, P; Roztocilová, L; Velísek, L | 1 |
| Turski, WA | 1 |
| Dasheiff, RM | 1 |
| Frederickson, CJ; Hernandez, MD; McGinty, JF | 1 |
| Grimes, L; Hong, JS; Lee, PH | 1 |
| Berger, ML; Hornykiewicz, O; Lassmann, H | 1 |
| Chastain, JE; Nelson, SR; Pazdernik, TL; Samson, F | 2 |
| Kaijima, M; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Campbell, J; Iverson, F; Lok, E; Nera, E; Truelove, J; Tryphonas, L | 1 |
| Kunimoto, M; Tanaka, T; Yonemasu, Y | 1 |
| Meldrum, BS; Millan, MH; Patel, S | 1 |
| Collins, JF; Meldrum, BS; Turski, L | 1 |
| Chapman, AG | 1 |
| Goldberg, O; Teichberg, VI | 1 |
| Gale, K; Piredda, S | 1 |
| Grimes, L; Hong, JS; Kanamatsu, T; McGinty, JF; Obie, J; Sabol, S; Yoshikawa, K | 1 |
| Ben-Ari, Y; Berger, ML; Lefauconnier, JM; Tremblay, E | 1 |
| Sloviter, RS | 1 |
| Grimes, L; Hong, JS; Kanamatsu, T; McGinty, JF | 1 |
| Grimes, L; Hong, J; McGinty, J; McLain, P; Mitchell, C; Tilson, H | 1 |
| Gall, C | 1 |
| Grimes, L; Hong, JS; Kanamatsu, T; McGinty, JF; Mitchell, CL; Obie, J | 1 |
| Chatt, AB; Ebersole, JS | 1 |
| Sako, K; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G | 1 |
| Breese, GR; Frye, GD; McCown, TJ; Peterson, SL | 1 |
| Ben-Ari, Y; Berger, ML; Charton, G | 1 |
| Ben-Ari, Y; Nitecka, L; Repressa, A; Tremblay, E | 1 |
| Hong, JS; Kanamatsu, T; McGinty, JF; Obie, J | 1 |
| Halsey, MJ; Meldrum, BS; Wardley-Smith, B | 1 |
| De Sarro, GB; Meldrum, BS; Patel, S | 1 |
| Nelson, SR; Olson, JP | 1 |
| Naquet, R; Pinard, E; Riche, D; Rigaud, AS; Seylaz, J | 1 |
| Feinerman, GS; Ruth, RE | 1 |
| Kondo, S; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Nadler, JV; Okazaki, MM | 1 |
| Sapolsky, RM; Stein, BA | 1 |
| Cronin, J; Dudek, FE | 1 |
| Tanaka, S; Tanaka, T; Yonemasu, Y | 2 |
| Bates, T; Bryan, M; Holmes, GL; Thompson, JL | 1 |
| Nadler, JV; Sater, RA | 1 |
| Holmes, GL; Thompson, JL | 1 |
| Bates, JF; Hall, TW; Peake, L; Standish, LJ; Swearengen, ES | 1 |
| Frederickson, CJ; Goik, SA; Hernandez, MD; McGinty, JF; Morton, JD | 1 |
| Stewart, DJ; Vanderwolf, CH | 1 |
| Amado, D; Berzaghi, Mda P; Cavalheiro, EA | 1 |
| Balm, M; Coyle, JT; Markl, A; Zaczek, R | 1 |
| Ferrendelli, JA; Mirski, MA | 1 |
| Klockgether, T; Meldrum, BS; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Nelson, SR; Pazdernik, TL; Samson, FE; Wade, JV | 1 |
| Joó, F; Szerdahelyi, P; Sztriha, L | 2 |
| Collins, RC; Olney, JW; Sloviter, RS | 1 |
| Sztriha, L | 1 |
| Benedek, G; Joó, F; Lelkes, Z; Sztriha, L | 1 |
| Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV | 2 |
| Meyer, DK; Sperk, G; Widmann, R | 1 |
| Morgan, DG; Ruth, RE | 1 |
| Nitecka, L; Tremblay, E | 1 |
| Goping, G; Klatzo, I; Nitsch, C | 1 |
| Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV; Okazaki, MM | 1 |
| Chapman, AG; Hart, GP; Meldrum, BS; Turski, L; Watkins, JC | 1 |
| Eck, E; Joó, F; Koltai, M; Szerdahelyi, P; Sztriha, L | 1 |
| Hubauer, H; Nitsch, C | 1 |
| Pei, YQ; Wu, XR; Zhao, DY; Zuo, QH | 1 |
| Baran, H; Hornykiewicz, O; Lassmann, H; Seitelberger, F; Sperk, G | 1 |
27 review(s) available for kainic acid and Seizures
| Article | Year |
|---|---|
Curcumin in epilepsy disorders.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Brain; Curcuma; Curcumin; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Rats; Seizures | 2018 |
Domoic acid epileptic disease.
Topics: Aged; Aged, 80 and over; Aging; Amnesia; Animal Diseases; Animals; Behavior, Animal; Bivalvia; Epilepsy; Epilepsy, Temporal Lobe; Female; Food Contamination; Hippocampus; Humans; Kainic Acid; Male; Marine Toxins; Middle Aged; Neuromuscular Depolarizing Agents; Neurotoxins; Olfactory Pathways; Rats; Recurrence; Sea Lions; Seizures; Shellfish Poisoning | 2014 |
Neuronal apoptosis after brief and prolonged seizures.
Topics: Animals; Apoptosis; Brain Damage, Chronic; Dentate Gyrus; Disease Models, Animal; Kainic Acid; Neurons; Pilocarpine; Rats; Seizures | 2002 |
Complications associated with genetic background effects in models of experimental epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Humans; Kainic Acid; Phenotype; Seizures; Species Specificity | 2002 |
The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus.
Topics: Animals; Brain; Cell Death; Dentate Gyrus; Excitatory Amino Acid Agonists; Kainic Acid; Neurons; Rats; Seizures; Status Epilepticus | 2002 |
New insights from the use of pilocarpine and kainate models.
Topics: Animals; Convulsants; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Muscarinic Agonists; Pilocarpine; Rats; Seizures; Status Epilepticus | 2002 |
Basic science and epilepsy: experimental epilepsy surgery.
Topics: Amygdala; Animals; Anticonvulsants; Cats; Combined Modality Therapy; Corpus Callosum; Drug Evaluation; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Models, Animal; Neurosurgical Procedures; Nootropic Agents; Pyrrolidinones; Rats; Seizures; Stereotaxic Techniques | 2001 |
Epilepsy-based changes in hippocampal excitability: causes and effects.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Nerve Net; Seizures; Synapses | 2006 |
MDMA and seizures: a dangerous liaison?
Topics: Acute Disease; Animals; Chronic Disease; Disease Susceptibility; Drug Interactions; Hallucinogens; Kainic Acid; Mice; Mossy Fibers, Hippocampal; N-Methyl-3,4-methylenedioxyamphetamine; Seizures | 2006 |
Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures.
Topics: Animals; Animals, Newborn; Brain; Chlorides; Disease Models, Animal; Fluoresceins; Hippocampus; Homeostasis; K Cl- Cotransporters; Kainic Acid; Neurons; Organic Chemicals; Rats; Receptors, GABA-A; RNA, Messenger; Seizures; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Status Epilepticus; Symporters | 2007 |
Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis?
Topics: Animals; Carbolines; Chromosome Mapping; Chromosomes; Convulsants; GABA Agonists; Genetic Predisposition to Disease; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Pentylenetetrazole; Potassium Channels; Quantitative Trait Loci; Seizures | 2007 |
Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis.
Topics: Animals; Biomarkers; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Humans; Kainic Acid; Models, Neurological; Monitoring, Physiologic; Rats; Seizures; Status Epilepticus; Telemetry; Time Factors; Videotape Recording | 2007 |
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Fever; Hippocampus; Hypoxia; Kainic Acid; Kindling, Neurologic; Pilocarpine; Rats; Recurrence; Seizures; Tetanus Toxin | 2007 |
[Toxic action of kainic acid as a model of Huntington chorea and epilepsy (review)].
Topics: Animals; Anticonvulsants; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Drug Interactions; gamma-Aminobutyric Acid; Hippocampus; Humans; Huntington Disease; Kainic Acid; Pyrrolidines; Rats; Seizures; Substantia Nigra | 1983 |
Neuronal receptor sites for kainic acid: correlations with neurotoxicity.
Topics: Animals; Binding Sites; Central Nervous System; Corpus Striatum; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Pyrrolidines; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Kainic Acid; Seizures | 1981 |
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Corpus Striatum; Denervation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kainic Acid; Kinetics; Mesencephalon; Muscimol; Neuroglia; Neurons; Rats; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Substantia Nigra; Tissue Distribution; Valproic Acid; Vigabatrin | 1981 |
Neurotoxic action of kainic acid.
Topics: Animals; Brain; Dendrites; Kainic Acid; Limbic System; Neurons; Neurotoxins; Pyrrolidines; Receptors, Cell Surface; Receptors, Kainic Acid; Seizures | 1983 |
Kainic acid and other excitotoxins: a comparative analysis.
Topics: Amino Acids; Animals; Humans; Kainic Acid; Mesencephalon; Nervous System; Neurons; Pyrrolidines; Seizures; Subcellular Fractions | 1981 |
Kainic acid seizures in the rat.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Epilepsy; Kainic Acid; Neuronal Plasticity; Rats; Seizures | 1994 |
Kainate-evoked modulation of gene expression in rat brain.
Topics: Animals; Brain; Dystrophin; Excitatory Amino Acids; Gene Expression; Kainic Acid; Models, Neurological; Nerve Degeneration; Rats; Receptors, Glutamate; RNA, Messenger; Seizures; Transcription Factors | 1997 |
Kainate, a double agent that generates seizures: two decades of progress.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Neural Inhibition; Presynaptic Terminals; Pyramidal Cells; Receptors, Kainic Acid; Seizures; Synapses | 2000 |
The Ca2+/calmodulin system in neuronal hyperexcitability.
Topics: Animals; Anticonvulsants; Brain; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Excitatory Amino Acid Agonists; Genes, fos; Hippocampus; Kainic Acid; Neurons; Seizures | 2001 |
Effects of epoetin alfa on the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Central Nervous System; Encephalomyelitis; Epoetin Alfa; Erythropoietin; Humans; Kainic Acid; Mice; Models, Animal; Neuroprotective Agents; Receptors, Erythropoietin; Recombinant Proteins; Seizures | 2001 |
Cell death and synaptic reorganizations produced by seizures.
Topics: Animals; Cell Death; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Neuronal Plasticity; Rats; Seizures; Status Epilepticus; Synaptic Transmission | 2001 |
Developmental differences in the neurobiology of epileptic brain damage.
Topics: Age Factors; Animals; Brain Damage, Chronic; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Seizures | 1992 |
Induction of heat shock (stress) genes in the mammalian brain by hyperthermia and other traumatic events: a current perspective.
Topics: Animals; Brain Chemistry; Brain Injuries; Brain Ischemia; Fever; Gene Expression Regulation; Heat-Shock Proteins; Humans; Infections; Kainic Acid; Mammals; Multigene Family; Nerve Tissue Proteins; Rabbits; Rats; Seizures | 1990 |
Seizure-induced alterations in the metabolism of hippocampal opioid peptides suggest opioid modulation of seizure-related behaviors.
Topics: Amygdala; Animals; Behavior, Animal; Colchicine; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hippocampus; Kainic Acid; Kindling, Neurologic; Seizures | 1988 |
1544 other study(ies) available for kainic acid and Seizures
| Article | Year |
|---|---|
Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity.
Topics: Animals; Convulsants; Excitatory Amino Acid Agonists; Isoxazoles; Mice; Pyrroles; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Structure-Activity Relationship | 1998 |
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice.
Topics: Animals; Demyelinating Diseases; Excitatory Amino Acid Agonists; Female; I-kappa B Kinase; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neurons; Neuroprotection; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Seizures | 2021 |
Joint single-cell measurements of nuclear proteins and RNA in vivo.
Topics: Animals; Antibodies; Brain; Computational Biology; Gene Expression Regulation; Genome-Wide Association Study; Kainic Acid; Mice; Nuclear Proteins; Reproducibility of Results; RNA; Seizures; Single-Cell Analysis; Transcription Factor RelA | 2021 |
Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Emergencies; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Mice; Pentylenetetrazole; Seizures; Status Epilepticus | 2021 |
The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.
Topics: CA1 Region, Hippocampal; Cholinergic Agents; Gene Deletion; GluK2 Kainate Receptor; Humans; Kainic Acid; Pilocarpine; Pyramidal Cells; Receptors, Kainic Acid; Seizures | 2022 |
Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes.
Topics: Animals; Excitatory Amino Acid Agonists; GABAergic Neurons; Hippocampus; Kainic Acid; Male; Mice; Neural Inhibition; Protein Transport; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Synapses | 2021 |
Hippocampal injury and learning deficits following non-convulsive status epilepticus in periadolescent rats.
Topics: Animals; Hippocampus; Kainic Acid; Neurons; Rats; Seizures; Status Epilepticus | 2021 |
Intravenous kainic acid induces status epilepticus and late onset seizures in mice.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus | 2021 |
Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model.
Topics: Animals; Clozapine; Disease Models, Animal; Kainic Acid; Levetiracetam; Ligands; Mice; Seizures | 2022 |
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microinjections; Seizures; Status Epilepticus | 2022 |
Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures.
Topics: Animals; Cells, Cultured; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Humans; Interneurons; Kainic Acid; Male; Rats; Recurrence; Seizures; Status Epilepticus; Stem Cell Transplantation; Stem Cells | 2021 |
Toward Evidence-Based Severity Assessment in Mouse Models with Repeated Seizures: (II.) Impact of Surgery and Intrahippocampal Kainate.
Topics: Animals; Corticosterone; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Seizures; Status Epilepticus | 2023 |
Fructose ingestion modifies NMDA receptors and exacerbates the seizures induced by kainic acid.
Topics: Animals; Eating; Fructose; High Fructose Corn Syrup; Hippocampus; Kainic Acid; Male; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; src-Family Kinases | 2022 |
Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice.
Topics: Animals; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Rats; Seizures | 2022 |
A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity.
Topics: Cytokines; Epilepsy; Humans; Interleukin-6; Kainic Acid; Neurons; Pluripotent Stem Cells; Seizures | 2022 |
Loss of efferent projections of the hippocampal formation in the mouse intrahippocampal kainic acid model.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures | 2022 |
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.
Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory Disorders; Rats; Rats, Wistar; Seizures; Vitamin B Complex | 2022 |
Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity.
Topics: Animals; Benzothiepins; Dimethyl Sulfoxide; Female; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Rats; Seizures | 2022 |
An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation.
Topics: Animals; Anxiety; Anxiety Disorders; gamma-Aminobutyric Acid; Humans; Kainic Acid; Lantana; Mice; Oxidative Stress; Plant Extracts; Seizures | 2022 |
Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fibroblast Growth Factors; Hippocampus; Kainic Acid; Mice; Seizures | 2022 |
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus | 2022 |
Sex differences in behavioral pathology induced by subconvulsive stimulation during early postnatal life are overcome by epileptic activity in the pre-juvenile weanling period.
Topics: Animals; Epilepsy; Female; Flurothyl; Hippocampus; Humans; Kainic Acid; Male; Rats; Seizures; Sex Characteristics; Status Epilepticus | 2022 |
Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy.
Topics: Acetylcarnitine; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Rats; Seizures; Status Epilepticus | 2022 |
Neferine, an Alkaloid from Lotus Seed Embryos, Exerts Antiseizure and Neuroprotective Effects in a Kainic Acid-Induced Seizure Model in Rats.
Topics: Alkaloids; Animals; Antineoplastic Agents; Benzylisoquinolines; Cytokines; Inflammasomes; Kainic Acid; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Seeds; Seizures | 2022 |
Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/β-Catenin Signaling Pathway.
Topics: Animals; Anticonvulsants; beta Catenin; Excitatory Amino Acid Antagonists; Flavones; Glutamic Acid; Hippocampus; Kainic Acid; Neuroprotective Agents; Rats; Seizures; Up-Regulation; Wnt Proteins; Wnt Signaling Pathway | 2022 |
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Genome-Wide Association Study; Hippocampus; Homeodomain Proteins; Humans; Kainic Acid; Mice; Seizures; Synaptic Transmission | 2022 |
Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Phenotype; Seizures | 2022 |
Epileptiform Events and Kainate Receptor Activity Changes Considerably during Entorhinal Cortex Development: An ex vivo Study.
Topics: Animals; Entorhinal Cortex; Hippocampus; Kainic Acid; Rats; Receptors, Kainic Acid; Seizures | 2022 |
Prophylactic Administration of Cannabidiol Reduces Microglial Inflammatory Response to Kainate-Induced Seizures and Neurogenesis.
Topics: Animals; Anticonvulsants; Cannabidiol; Epilepsy; Humans; Kainic Acid; Mice; Microglia; Neurogenesis; Seizures | 2022 |
The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Topics: Animals; CLOCK Proteins; Epilepsy, Temporal Lobe; Ferroptosis; Kainic Acid; Mice; Mice, Knockout; PPAR gamma; Seizures | 2022 |
Hippocampal orexin-1 and endocannabinoid-1 receptors underlie the kainate-induced occlusion in theta-burst long- term potentiation.
Topics: Animals; CA1 Region, Hippocampal; Electric Stimulation; Endocannabinoids; Hippocampus; Kainic Acid; Long-Term Potentiation; Orexins; Seizures | 2022 |
Blocking ERK-DAPK1 Axis Attenuates Glutamate Excitotoxicity in Epilepsy.
Topics: Animals; Death-Associated Protein Kinases; Epilepsy; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Kainic Acid; Mice; Seizures | 2022 |
Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Fibronectins; Hippocampus; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures | 2022 |
Probable mechanisms involved in the antiepileptic activity of Clerodendrum polycephalum Baker (Labiatae) leaf extract in mice exposed to chemical-induced seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Arginine; Clerodendrum; Cyclooxygenase 2; Flumazenil; Guanosine Monophosphate; Kainic Acid; Lamiaceae; Methylene Blue; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Picrotoxin; Plant Extracts; Receptors, GABA-A; Seizures; Soluble Guanylyl Cyclase; Spasm | 2022 |
Electrophysiological Evidence for Anti-epileptic Property of Taurine.
Topics: Amino Acids; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Isoniazid; Kainic Acid; Mice; Receptors, GABA-A; Seizures; Taurine | 2022 |
Inhibiting SRC activity attenuates kainic-acid induced mouse epilepsy via reducing NR2B phosphorylation and full-length NR2B expression.
Topics: Animals; Calpain; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Phosphorylation; Seizures | 2022 |
Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy; Kainic Acid; Long-Term Potentiation; Mice; Mossy Fibers, Hippocampal; Seizures | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Seizures | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interleukin-1beta; Kainic Acid; Mice; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Pilocarpine; Seizures; Status Epilepticus | 2022 |
PLPP/CIN-mediated DARPP-32 serine 97 dephosphorylation delays the seizure onset in response to kainic acid in the mouse hippocampus.
Topics: Animals; Casein Kinase II; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Hippocampus; Kainic Acid; Mice; Phosphates; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Pyridoxal; Seizures; Serine | 2022 |
Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway.
Topics: Animals; Anticonvulsants; Epilepsy; Ferroptosis; Glutamic Acid; Kainic Acid; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Polyphenols; Quercetin; Seizures; Signal Transduction; Sirtuin 1 | 2022 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2022 |
Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems; Animals; Anti-Inflammatory Agents; Carbamazepine; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Hippocampus; HMGB1 Protein; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Kainic Acid; N-Methylaspartate; Rats; Receptors, Interleukin-1; Rutin; Seizures; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2022 |
Cannabidiol inhibits microglia activation and mitigates neuronal damage induced by kainate in an in-vitro seizure model.
Topics: Animals; Cannabidiol; Dronabinol; Epilepsy; Kainic Acid; Microglia; Rats; Seizures | 2022 |
Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mice, Knockout; Microglia; Seizures; Status Epilepticus; Tumor Necrosis Factor-alpha | 2023 |
Integration of the CA2 region in the hippocampal network during epileptogenesis.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Seizures | 2023 |
Oxygenated Water Increases Seizure Threshold in Various Rodent Seizure Models.
Topics: Animals; Betamethasone; Epilepsy; Kainic Acid; Oxygen; Rodentia; Seizures; Spasm; Water | 2022 |
Characterization of the anticonvulsant effect of dapsone on metabolic activity assessed by [
Topics: Animals; Anticonvulsants; Dapsone; Epilepsy; Fluorodeoxyglucose F18; Hippocampus; Kainic Acid; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2023 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Mice; Seizures | 2023 |
TMT-based proteomics profile reveals changes of the entorhinal cortex in a kainic acid model of epilepsy in mice.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Proteomics; Seizures; Tandem Mass Spectrometry | 2023 |
Administration of Kainic Acid Differentially Alters Astrocyte Markers and Transiently Enhanced Phospho-tau Level in Adult Rat Hippocampus.
Topics: Adult; Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Rats; Seizures; tau Proteins | 2023 |
Repurposing of cholesterol-lowering agents in status epilepticus: A neuroprotective effect of simvastatin.
Topics: Animals; Hippocampus; Kainic Acid; Mice; Neuroprotective Agents; Pilot Projects; Saline Solution; Seizures; Simvastatin; Status Epilepticus | 2023 |
Alpha-Pinene Exerts Antiseizure Effects by Preventing Oxidative Stress and Apoptosis in the Hippocampus in a Rat Model of Temporal Lobe Epilepsy Induced by Kainate.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Oxidative Stress; Rats; Rats, Wistar; Seizures | 2023 |
Anticonvulsant Effects of Royal Jelly in Kainic Acid-Induced Animal Model of Temporal Lobe Epilepsy Through Antioxidant Activity.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 2023 |
Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Kainic Acid; Neurosteroids; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2023 |
Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2023 |
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
Topics: Animals; Apoptosis; Caspase 1; Caspase 3; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Seizures | 2023 |
Activation of the PI3K/AKT/mTOR Pathway in Cajal-Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures.
Topics: Animals; Female; Kainic Acid; Mammals; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Seizures; TOR Serine-Threonine Kinases | 2023 |
Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Microglia; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2023 |
RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Oxidative Stress; Pyramidal Cells; RGS Proteins; Seizures; Status Epilepticus | 2023 |
Age and Sex as Determinants of Acute Domoic Acid Toxicity in a Mouse Model.
Topics: Animals; Disease Models, Animal; Female; Kainic Acid; Male; Marine Toxins; Mice; Neurotoxins; Seizures | 2023 |
The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit.
Topics: Animals; Apelin; Endocytosis; Kainic Acid; Mice; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission | 2023 |
Sex and Estrous Cycle Stage Shape Left-Right Asymmetry in Chronic Hippocampal Seizures in Mice.
Topics: Animals; Epilepsy, Temporal Lobe; Estrous Cycle; Female; Hippocampus; Kainic Acid; Male; Mice; Seizures; Temporal Lobe | 2023 |
Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
Topics: Animals; Biomarkers; Diazepam; Epilepsy; Intermediate Filaments; Kainic Acid; Ketamine; Mice; Neurofilament Proteins; Seizures | 2023 |
GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures.
Topics: Animals; Carrier Proteins; Cytokines; Disease Models, Animal; Epilepsy; Inflammasomes; Kainic Acid; Kruppel-Like Factor 4; Lipopolysaccharides; Mice; Microglia; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Seizures; Thioredoxins; Transcription Factors | 2023 |
Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy.
Topics: Animals; Astrocytes; Epilepsy; Hippocampus; Kainic Acid; Mice; Seizures | 2023 |
Principal neurons in the olfactory cortex mediate bidirectional modulation of seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Neurons; Piriform Cortex; Seizures | 2023 |
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Neuroinflammatory Diseases; NF-kappa B; Ryanodine Receptor Calcium Release Channel; Seizures; Serpins; Signal Transduction | 2023 |
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Neurons; Oxidative Stress; Rats; Reactive Oxygen Species; Seizures; Sestrins; Status Epilepticus; Transcription Factors | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizures; Zebrafish | 2023 |
GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice.
Topics: Animals; Epilepsy, Temporal Lobe; Kainic Acid; Lipopolysaccharides; Mice; Microglia; Seizures | 2023 |
CA3 principal cell activation triggers hypersynchronous-onset seizures in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Seizures; Status Epilepticus | 2023 |
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.
Topics: Animals; Castration; Epilepsy; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus; Steroids | 2023 |
Morphological alterations of the neuronal Golgi apparatus upon seizures.
Topics: Adult; Animals; Epilepsy; Golgi Apparatus; Hippocampus; Humans; Kainic Acid; Neurons; Rats; Seizures | 2023 |
Slack K
Topics: Animals; Kainic Acid; Mice; Mice, Knockout; Neurons; Potassium Channels; Potassium Channels, Sodium-Activated; Seizures | 2023 |
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy.
Topics: Animals; Epilepsy; Extracellular Matrix; Kainic Acid; Mice; Neurons; Seizures | 2023 |
The role of subicular VIP-expressing interneurons on seizure dynamics in the intrahippocampal kainic acid model of temporal lobe epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Seizures; Vasoactive Intestinal Peptide | 2023 |
Clinical signs and mortality of non-released stranded California sea lions housed in display facilities: the suspected role of prior exposure to algal toxins.
Topics: Animals; Animals, Zoo; Epilepsy; Kainic Acid; Marine Toxins; Sea Lions; Seizures; United States | 2019 |
Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neural Pathways; Rats, Sprague-Dawley; Seizures | 2019 |
Inhibition of Nwd1 activity attenuates neuronal hyperexcitability and GluN2B phosphorylation in the hippocampus.
Topics: Animals; Evoked Potentials; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Kainic Acid; Mice; Neurons; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptic Transmission | 2019 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2 | 2020 |
[Correlation of phosphorylated S6 protein expression in blood and brain tissue in mice and rats with kainic acid-induced seizure].
Topics: Animals; Brain; Gene Expression Regulation; Kainic Acid; Mice; Mice, Inbred C57BL; Phosphorylation; Rats; Rats, Sprague-Dawley; Seizures | 2019 |
Xenon exerts anti-seizure and neuroprotective effects in kainic acid-induced status epilepticus and neonatal hypoxia-induced seizure.
Topics: Animals; Animals, Newborn; Brain; Convulsants; Hypoxia, Brain; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Xenon | 2019 |
A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Conditioning, Classical; Disease Models, Animal; Fragile X Mental Retardation Protein; Kainic Acid; Male; Mice; Mice, Knockout; Motor Activity; Seizures; Social Behavior; Status Epilepticus | 2019 |
Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Cognition; Epilepsy; Insulin; Kainic Acid; Male; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2020 |
Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Clozapine; Electroencephalography; Epilepsy, Temporal Lobe; Genetic Vectors; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures | 2019 |
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module.
Topics: Animals; Biotin; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Endothelial Cells; Infarction, Middle Cerebral Artery; Kainic Acid; Mice; Mice, Transgenic; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Permeability; Pertussis Toxin; Seizures; Signal Transduction; Stroke; Transcriptome | 2019 |
Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model.
Topics: Animals; Anxiety; Azabicyclo Compounds; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Seizures; Signal Transduction; Status Epilepticus; Triazines | 2020 |
CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; MAP Kinase Signaling System; Mice; Neurons; Receptors, CXCR; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses | 2019 |
Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration.
Topics: Animals; Convulsants; Female; Genetic Background; Interpersonal Relations; Kainic Acid; Male; Memory; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures; Species Specificity | 2019 |
Brainstem activity, apnea, and death during seizures induced by intrahippocampal kainic acid in anaesthetized rats.
Topics: Anesthetics, Intravenous; Animals; Brain Stem; Death, Sudden; Electroencephalography; Female; Hippocampus; Kainic Acid; Rats; Rats, Long-Evans; Seizures; Sleep Apnea, Central | 2019 |
Role of Macrophages in Status Epilepticus Predisposing to Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; CA3 Region, Hippocampal; Convulsants; Female; Kainic Acid; Macrophages; Microinjections; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Macrophage Colony-Stimulating Factor; Seizures; Signal Transduction; Status Epilepticus | 2020 |
SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures.
Topics: Alternative Splicing; Animals; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Immediate-Early Proteins; Kainic Acid; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Mice, Transgenic; Neurons; Protein Isoforms; Protein Serine-Threonine Kinases; Seizures; Status Epilepticus | 2020 |
Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi.
Topics: Animals; Astrocytes; Bestrophins; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Neural Inhibition; Receptors, GABA-A; Seizures | 2020 |
MicroRNA-451 Aggravates Kainic Acid-induced Seizure and Neuronal Apoptosis by Targeting GDNF.
Topics: Animals; Apoptosis; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; HEK293 Cells; Hippocampus; Humans; Kainic Acid; Mice; Mice, Knockout; MicroRNAs; Neurons; Seizures | 2020 |
The small GTPase ARF6 regulates GABAergic synapse development.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Animals; Cells, Cultured; GABAergic Neurons; Gene Knockdown Techniques; Genetic Vectors; Hippocampus; Humans; Kainic Acid; Male; Mice, Inbred C57BL; Point Mutation; Rats; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Seizures; Synapses | 2020 |
No Synergistic Effect of Silibinin and Morin in a Kainic Acid-Induced Epileptic Mouse Model.
Topics: Animals; Dentate Gyrus; Drug Synergism; Epilepsy, Temporal Lobe; Flavonoids; Kainic Acid; Mice; Seizures; Silybin | 2020 |
A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling.
Topics: Animals; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; MicroRNAs; N-Methylaspartate; Neurotoxins; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ribonuclease III; Seizures; Signal Transduction; Specific Pathogen-Free Organisms; Subcellular Fractions; Transcriptome; Up-Regulation | 2020 |
The effects of ammonia stimulation on kainate-induced status epilepticus and anterior piriform cortex electrophysiology.
Topics: Ammonia; Animals; Electroencephalography; Kainic Acid; Male; Piriform Cortex; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2020 |
Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Gene Expression Profiling; Hippocampus; Kainic Acid; Neurons; Rats, Sprague-Dawley; Receptors, AMPA; Seizures | 2020 |
Experimentally Induced Convulsive Seizures Are Modulated in Part by Zinc Ions through the Pharmacoresistant Ca
Topics: Animals; Calcium Channels, R-Type; Cation Transport Proteins; Electroencephalography; gamma-Aminobutyric Acid; Hippocampus; Histidine; Ions; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Seizures; Severity of Illness Index; Zinc | 2020 |
Dynamic functional connectivity and graph theory metrics in a rat model of temporal lobe epilepsy reveal a preference for brain states with a lower functional connectivity, segregation and integration.
Topics: Animals; Brain; Brain Mapping; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Models, Animal; Nerve Net; Neural Pathways; Rats; Seizures | 2020 |
Kainic acid-induced seizures in the common marmoset.
Topics: Animals; Behavior, Animal; Callithrix; Diazepam; Female; Kainic Acid; Male; Seizures | 2020 |
Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats.
Topics: Animals; Convulsants; Electroencephalography; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Transcranial Direct Current Stimulation | 2020 |
Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.
Topics: Animals; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intraventricular; Kainic Acid; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred ICR; Seizures; Up-Regulation | 2020 |
Edaravone inhibits procaspase-3 denitrosylation and activation through FasL-Trx2 pathway in KA-induced seizure.
Topics: Animals; Caspase 3; Disease Models, Animal; Edaravone; Fas Ligand Protein; Kainic Acid; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Specific Pathogen-Free Organisms | 2020 |
Dexamethasone after early-life seizures attenuates increased susceptibility to seizures, seizure-induced microglia activation and neuronal injury later in life.
Topics: Animals; Dexamethasone; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Macrophage Activation; Male; Microglia; Neurons; Rats, Long-Evans; Seizures | 2020 |
Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy.
Topics: Animals; Antioxidants; Autophagosomes; Autophagy; Autophagy-Related Proteins; CA3 Region, Hippocampal; Disease Models, Animal; DNA-Binding Proteins; Kainic Acid; Male; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Quercetin; Seizures; Signal Transduction | 2020 |
Status Epilepticus Dynamics Predicts Latency to Spontaneous Seizures in the Kainic Acid Model.
Topics: Animals; Brain; Cell Death; Cell Survival; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Gamma Rhythm; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Theta Rhythm | 2020 |
Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2020 |
The adenosine A1 receptor agonist WAG 994 suppresses acute kainic acid-induced status epilepticus in vivo.
Topics: Adenosine A1 Receptor Agonists; Animals; Electroencephalography; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A1; Seizures; Status Epilepticus | 2020 |
Microglial depletion aggravates the severity of acute and chronic seizures in mice.
Topics: Animals; Disease Models, Animal; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; Microglia; Seizures; Status Epilepticus | 2020 |
Epileptogenesis-induced changes of hippocampal-piriform connectivity.
Topics: Animals; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2020 |
Accurate detection of spontaneous seizures using a generalized linear model with external validation.
Topics: Animals; Area Under Curve; Disease Models, Animal; Electrocorticography; Electroencephalography; Epilepsies, Partial; Excitatory Amino Acid Agonists; Kainic Acid; Linear Models; Machine Learning; Rats; Reproducibility of Results; ROC Curve; Seizures; Signal Processing, Computer-Assisted | 2020 |
P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation.
Topics: Action Potentials; Amino Acid Motifs; Animals; Brain Waves; Female; HEK293 Cells; Hippocampus; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Seizures; Shal Potassium Channels | 2020 |
Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels.
Topics: Animals; Hippocampus; Kainic Acid; Mice; ORAI1 Protein; Pilocarpine; Pyramidal Cells; Seizures | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flurothyl; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenotype; Quantitative Trait Loci; Seizures; Sudden Unexpected Death in Epilepsy; Whole Genome Sequencing | 2020 |
P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures.
Topics: Adaptor Proteins, Signal Transducing; Animals; Astrocytes; Autophagy; Carrier Proteins; Focal Adhesion Protein-Tyrosine Kinases; Heat-Shock Proteins; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Receptors, Purinergic P2X7; Seizures; Serine; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Adipose-derived stem cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Learning; Male; Maze Learning; Memory; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nerve Growth Factors; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures.
Topics: Adipocytes; Animals; Biotinylation; Cell Line; DNA-Binding Proteins; Epilepsy; Exosomes; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; In Situ Hybridization, Fluorescence; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA, Circular; RNA, Long Noncoding; Seizures; Signal Transduction; Suppressor of Cytokine Signaling Proteins | 2020 |
Combination therapy with dipeptidyl peptidase-4 and P2X7 purinoceptor inhibitors gives rise to antiepileptic effects in rats.
Topics: Animals; Anticonvulsants; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; DNA Fragmentation; Drug Therapy, Combination; Electroencephalography; Epilepsy; Gliosis; Hippocampus; Kainic Acid; Linagliptin; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Rosaniline Dyes; Seizures; Treatment Outcome | 2020 |
Dietary omega-3 fatty acids prevent neonatal seizure-induced early alterations in the hippocampal glutamatergic system and memory deficits in adulthood.
Topics: Animals; Diet; Epilepsy; Fatty Acids, Omega-3; Female; Glutamic Acid; Hippocampus; Kainic Acid; Male; Memory Disorders; Pregnancy; Rats; Rats, Wistar; Seizures | 2022 |
Suppression of phrenic nerve activity as a potential predictor of imminent sudden unexpected death in epilepsy (SUDEP).
Topics: Adenosine Kinase; Animals; Kainic Acid; Male; Phrenic Nerve; Predictive Value of Tests; Rats; Rats, Wistar; Seizures; Sudden Unexpected Death in Epilepsy; Tubercidin | 2021 |
Electrochemical Sensing of Ascorbate as an Index of Neuroprotection from Seizure Activity by Physical Exercise in Freely Moving Rats.
Topics: Animals; Ascorbic Acid; Kainic Acid; Neuroprotection; Physical Conditioning, Animal; Rats; Seizures | 2021 |
Seizure activity and brain damage in a model of focal non-convulsive status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Guinea Pigs; Kainic Acid; Seizures; Status Epilepticus | 2021 |
Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice.
Topics: Animals; Antagomirs; Brain; Dose-Response Relationship, Drug; Kainic Acid; Male; Mice; MicroRNAs; Seizures | 2021 |
Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm.
Topics: Animals; Cognition; Deep Brain Stimulation; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Kindling, Neurologic; Learning; Memory; Mice; Mice, Inbred C57BL; Psychomotor Performance; Seizures; Septum of Brain; Theta Rhythm | 2021 |
miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus.
Topics: Animals; Down-Regulation; Epilepsy; Gene Knockdown Techniques; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; RNA, Messenger; Seizures; Status Epilepticus; Synaptic Transmission; Synaptosomal-Associated Protein 25; Synaptotagmin I | 2021 |
Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models.
Topics: Animals; Cognition; Glycosylphosphatidylinositols; Humans; Kainic Acid; Mammals; Mice; Mice, Knockout; Mutation; Neurons; Seizures | 2021 |
A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model.
Topics: Age Factors; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Brain; Brain Injuries, Traumatic; Cerebral Hemorrhage; Kainic Acid; Male; Seizures; Severity of Illness Index; Swine; Time Factors | 2021 |
Response: Usefulness of the post-kainate spontaneous recurrent seizure model for screening for antiseizure and for neuroprotective effects.
Topics: Epilepsy, Generalized; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Neuroprotective Agents; Seizures | 2021 |
Absence of RNA-binding protein FXR2P prevents prolonged phase of kainate-induced seizures.
Topics: Animals; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; RNA-Binding Proteins; Seizures; Status Epilepticus | 2021 |
Spreading depression as an innate antiseizure mechanism.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Stem; Cortical Spreading Depression; Depression; Female; Gene Knock-In Techniques; Kainic Acid; Male; Mice; Nervous System; Optogenetics; Penicillins; Potassium Channel Blockers; Seizures; Tetrodotoxin | 2021 |
Inhibition of microRNA-129-2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; MicroRNAs; Rats; Receptors, GABA-A; Seizures | 2021 |
Diurnal burden of spontaneous seizures in early epileptogenesis in the post-kainic acid rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Compounding; Drug Discovery; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Temporal Lobe; Everolimus; High-Throughput Screening Assays; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Seizures; Translational Research, Biomedical | 2021 |
Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kainic Acid; Male; Mice; Microglia; Seizures; Status Epilepticus | 2021 |
Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure.
Topics: Animals; Cerebral Cortex; Hippocampus; Iron; Kainic Acid; Male; Malonates; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Status Epilepticus; Succinic Acid | 2021 |
Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Gene Knock-In Techniques; Hippocampus; Kainic Acid; Mice; Seizures; Up-Regulation | 2021 |
Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo.
Topics: Action Potentials; Acute Disease; Animals; CA3 Region, Hippocampal; Disease Models, Animal; GABAergic Neurons; Gene Silencing; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Male; Mice; Optogenetics; Parvalbumins; Pyramidal Cells; Seizures; Synaptic Transmission; Time Factors | 2021 |
ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model.
Topics: Animals; Benzothiazoles; Endoplasmic Reticulum Stress; Fragile X Mental Retardation Protein; Fragile X Syndrome; Genetic Predisposition to Disease; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Net; Patch-Clamp Techniques; Seizures; Toluene; Tumor Suppressor Protein p53 | 2021 |
Repeated exposure to microcystin-leucine-arginine potentiates excitotoxicity induced by a low dose of kainate.
Topics: Animals; Arginine; Bacterial Toxins; Hippocampus; Kainic Acid; Leucine; Male; Mice; Mice, Inbred C57BL; Microcystins; Microglia; Neurotoxins; Oxidative Stress; Seizures | 2021 |
Hypercapnia-induced brain acidosis: Effects and putative mechanisms on acute kainate induced seizures.
Topics: Acidosis; Animals; Anticonvulsants; Brain; Carbon Dioxide; Hypercapnia; Kainic Acid; Male; Oxygen; Rats; Rats, Sprague-Dawley; Seizures | 2017 |
Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats.
Topics: Acupuncture Points; Animals; Biomarkers; CA1 Region, Hippocampal; Chemokine CCL2; Cyclooxygenase 2; Electric Stimulation; Electroacupuncture; Epilepsy; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Rats; Receptors, CCR2; S100 Calcium Binding Protein beta Subunit; Seizures; Time Factors | 2017 |
Faster flux of neurotransmitter glutamate during seizure - Evidence from 13C-enrichment of extracellular glutamate in kainate rat model.
Topics: Animals; Carbon Isotopes; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neurotransmitter Agents; Rats, Wistar; Seizures | 2017 |
Effect of Pharmacological Modulation of Activity of Metabotropic Glutamate Receptors on Their Gene Expression after Excitotoxic Damage in Hippocampal Neurons.
Topics: Animals; Bridged Bicyclo Compounds; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Frontal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neurons; Organ Specificity; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Seizures; Stereotaxic Techniques | 2017 |
Effects of low-frequency electrical stimulation of the anterior piriform cortex on kainate-induced seizures in rats.
Topics: Animals; Deep Brain Stimulation; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Male; Piriform Cortex; Rats; Rats, Sprague-Dawley; Seizures | 2017 |
Rapamycin Attenuates Acute Seizure-induced Astrocyte Injury in Mice in Vivo.
Topics: Animals; Astrocytes; Disease Models, Animal; Kainic Acid; Mice; Seizures; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Vacuoles | 2017 |
The glutamate receptor antagonists CNQX and MPEP decrease fast ripple events in rats treated with kainic acid.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electroencephalography; Hippocampus; Kainic Acid; Male; Pyridines; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 2017 |
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques | 2017 |
Closed-Loop Neurostimulators: A Survey and A Seizure-Predicting Design Example for Intractable Epilepsy Treatment.
Topics: Algorithms; Animals; Antinematodal Agents; Brain; Drug Resistant Epilepsy; Electric Stimulation; Electroencephalography; Equipment Design; Implantable Neurostimulators; Kainic Acid; Microelectrodes; Rats; Seizures; Wireless Technology | 2017 |
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Fenclonine; Hippocampus; Kainic Acid; Male; Maze Learning; Memory Disorders; Neurons; Rats, Wistar; Seizures; Serotonin; Spatial Memory | 2017 |
Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats.
Topics: Animals; Aromatase; Cerebral Cortex; Epididymis; Hippocampus; Kainic Acid; Levetiracetam; Male; Nerve Tissue Proteins; Oxidoreductases Acting on CH-CH Group Donors; Piracetam; Rats, Wistar; Seizures; Testis; Time Factors; Vas Deferens | 2017 |
Establishment of a rhesus monkey model of chronic temporal lobe epilepsy using repetitive unilateral intra-amygdala kainic acid injections.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Gliosis; Infusion Pumps, Implantable; Kainic Acid; Macaca mulatta; Male; Neurosurgical Procedures; Pyramidal Cells; Seizures; Temporal Lobe | 2017 |
Synergistic effect of mild hypothermia and the Notch inhibitor DAPT against post stroke seizures.
Topics: Animals; Cerebral Cortex; Diamines; Down-Regulation; Hippocampus; Hypothermia; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Notch; Seizures; Signal Transduction; Stroke; Thiazoles; Up-Regulation | 2017 |
Effects of spontaneous recurrent seizures on cognitive function via modulation of SNAREs expression.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Escape Reaction; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Locomotion; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Seizures; SNARE Proteins; Synapses; Synaptosomal-Associated Protein 25; Synaptotagmin I; Valproic Acid; Vesicle-Associated Membrane Protein 2 | 2018 |
CD36 Deficiency Suppresses Epileptic Seizures.
Topics: Action Potentials; Analysis of Variance; Animals; CD36 Antigens; Convulsants; Disease Models, Animal; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Seizures | 2017 |
JNK1 inhibition by Licochalcone A leads to neuronal protection against excitotoxic insults derived of kainic acid.
Topics: Animals; Anticonvulsants; Cell Survival; Chalcones; Hippocampus; Inflammation; Kainic Acid; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Neurons; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Seizures | 2018 |
Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antioxidants; Apoptosis; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Oxidative Stress; PC12 Cells; Pentacyclic Triterpenes; Rats; Seizures; Triterpenes | 2018 |
Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls.
Topics: Acute Disease; Animals; Brain; Disease Models, Animal; Gene Expression Profiling; Kainic Acid; Lipids; Mice; Seizures | 2018 |
Favorable adverse effect profile of brivaracetam vs levetiracetam in a preclinical model.
Topics: Animals; Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Hippocampus; Humans; Kainic Acid; Levetiracetam; Male; Pyrrolidinones; Rats; Seizures; Synaptic Transmission | 2018 |
Intracerebroventricular administration of cigarette smoke condensate induced generalized seizures reduced by muscarinic receptor antagonist in rats.
Topics: Animals; Atropine; Convulsants; Epilepsy; Female; Kainic Acid; Male; Muscarinic Antagonists; Pregnancy; Rats; Receptors, Muscarinic; Seizures; Smoking | 2018 |
A pilot study of the role of the claustrum in attention and seizures in rats.
Topics: Animals; Attention; Basal Ganglia; Conditioning, Operant; Electric Stimulation; Evoked Potentials; Hippocampus; Kainic Acid; Male; Neural Pathways; Pilot Projects; Rats, Sprague-Dawley; Seizures | 2018 |
Seizure development in the acute intrahippocampal epileptic focus.
Topics: Animals; Disease Models, Animal; Electrophysiological Phenomena; Hippocampus; Humans; Kainic Acid; Male; Rats; Seizures | 2018 |
Developmental and sex differences in tetramethylenedisulfotetramine (TMDT)-induced syndrome in rats.
Topics: Animals; Brain; Bridged-Ring Compounds; Cell Death; Dose-Response Relationship, Drug; Electroencephalography; Female; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Random Allocation; Rats, Sprague-Dawley; Seizures; Sex Characteristics | 2018 |
Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Tocopherol; Animals; Blood-Brain Barrier; Disease Models, Animal; Gene Expression Regulation; Inflammation; Kainic Acid; Male; MicroRNAs; Nerve Degeneration; Oocytes; Oxidative Stress; Rats, Sprague-Dawley; Receptors, GABA; Seizures; Status Epilepticus; Xenopus | 2018 |
Astaxanthin protects against kainic acid-induced seizures and pathological consequences.
Topics: Animals; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Seizures; Xanthophylls | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Kainic Acid; Male; Malondialdehyde; Maze Learning; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Phenytoin; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Seizures; Sesquiterpenes; Status Epilepticus | 2018 |
Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice.
Topics: Animals; Anticonvulsants; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Hippocampus; Kainic Acid; Letrozole; Male; Mice; Random Allocation; Seizures; Testosterone | 2018 |
Different ketogenesis strategies lead to disparate seizure outcomes.
Topics: Animals; Blood Glucose; Body Weight; Brain; Diet, Ketogenic; Disease Models, Animal; Electric Stimulation; Fasting; Kainic Acid; Ketosis; Male; Mice; Mitochondria; Random Allocation; Seizures; Treatment Outcome | 2018 |
Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats.
Topics: Animals; Celecoxib; Cyclooxygenase 2; Female; Hippocampus; HMGB1 Protein; Immunologic Factors; Kainic Acid; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reaction Time; Recurrence; Seizures; Signal Transduction; Toll-Like Receptor 4 | 2018 |
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mefloquine; Mice; Nerve Tissue Proteins; Probenecid; Seizures; Signal Transduction | 2018 |
Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; Neuronal Plasticity; Seizures; Status Epilepticus | 2018 |
MiR-134 expression and changes in inflammatory cytokines of rats with epileptic seizures.
Topics: Animals; Brain; Cell Proliferation; Cytokines; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Male; MicroRNAs; Neurons; Rats; Seizures | 2018 |
Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice.
Topics: Alkanes; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Entorhinal Cortex; gamma-Aminobutyric Acid; Kainic Acid; Male; Membrane Potentials; Mice, Inbred C57BL; Neurons; Phenols; Receptors, GABA-A; Seizures | 2018 |
RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.
Topics: Animals; Gene Expression Profiling; Gene Ontology; Hippocampus; Immunity; Interferon-beta; Kainic Acid; Mice; Microglia; Seizures; Sequence Analysis, RNA; Signal Transduction; Up-Regulation | 2018 |
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; Kainic Acid; Male; Mice; Pilocarpine; Seizures | 2019 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Seizures | 2018 |
Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mice, Inbred C57BL; Neurons; Seizures | 2018 |
Anterior nucleus of thalamus stimulation inhibited abnormal mossy fiber sprouting in kainic acid-induced epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cell Nucleus; Deep Brain Stimulation; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Seizures; Semaphorin-3A | 2018 |
Anticonvulsant and Neuroprotective Effects of Cannabidiol During the Juvenile Period.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Cannabidiol; Electroencephalography; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2018 |
Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity.
Topics: Animals; Astrocytes; Calcium Signaling; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Inositol 1,4,5-Trisphosphate Receptors; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Neurons; Seizures | 2018 |
Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.
Topics: Animals; Brain; Cistanche; Cytokines; Disease Models, Animal; Epilepsy; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Glycosides; Inflammation; Kainic Acid; Male; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2018 |
The Ethanol Fraction of White Rose Petal Extract Abrogates Excitotoxicity-Induced Neuronal Damage
Topics: Animals; Antioxidants; Brain; Cytokines; Ethanol; Flowers; Humans; Inflammation; Kainic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Neural Stem Cells; Oxidative Stress; Phytotherapy; Plant Extracts; Rosa; Seizures | 2018 |
Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Reaction Time; Receptor, Galanin, Type 2; Receptor, Galanin, Type 3; Seizures | 2018 |
Acid reflux induced laryngospasm as a potential mechanism of sudden death in epilepsy.
Topics: Animals; Death, Sudden; Disease Models, Animal; Epilepsy; Esophagus; Female; Gastroesophageal Reflux; Hydrogen-Ion Concentration; Kainic Acid; Laryngismus; Rats, Long-Evans; Respiration; Seizures | 2018 |
AMPA receptors and seizures mediate hippocampal radial glia-like stem cell proliferation.
Topics: Animals; Animals, Newborn; Benzodiazepines; Cell Death; Cell Proliferation; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Ki-67 Antigen; Male; Membrane Potentials; Nerve Tissue Proteins; Neuroglia; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stem Cells | 2018 |
[Induction of Epileptic Seizures in Mouse Models of Chronic Restraint Stress].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Random Allocation; Restraint, Physical; Seizures; Stress, Psychological | 2018 |
A cynomolgus monkey model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Macaca fascicularis; Male; Seizures; Temporal Lobe | 2019 |
Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway.
Topics: Animals; Apoptosis; Base Sequence; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Hippocampus; HSP20 Heat-Shock Proteins; Inflammation; Kainic Acid; Male; MAP Kinase Kinase Kinase 5; Neurons; Phosphorylation; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2019 |
Efficacy of dapsone administered alone or in combination with diazepam to inhibit status epilepticus in rats.
Topics: Animals; Anticonvulsants; Dapsone; Diazepam; Electroencephalography; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2019 |
Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Convulsants; Disease Models, Animal; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Neuroprotective Agents; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Vitamin D | 2019 |
A triheptanoin-supplemented diet rescues hippocampal hyperexcitability and seizure susceptibility in FoxG1
Topics: Animals; Disease Susceptibility; Forkhead Transcription Factors; Haploinsufficiency; Hippocampus; K Cl- Cotransporters; Kainic Acid; Mice; Nerve Tissue Proteins; Seizures; Symporters; Triglycerides; Vesicular Inhibitory Amino Acid Transport Proteins | 2019 |
Protective effects of lycopene on kainic acid-induced seizures.
Topics: Animals; Antioxidants; Blinking; Disease Models, Animal; Drug Administration Schedule; Excitatory Amino Acid Agonists; Gene Expression; Glutathione; Hippocampus; Kainic Acid; Lycopene; Malondialdehyde; Mice; Receptors, GABA; RNA, Messenger; Seizures; Stereotyped Behavior; Superoxide Dismutase; Time Factors | 2019 |
Regional and temporal regulation and role of somatostatin receptor subtypes in the mouse brain following systemic kainate-induced acute seizures.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Receptors, Somatostatin; Seizures | 2019 |
Acute Seizure Control Efficacy of Multi-Site Closed-Loop Stimulation in a Temporal Lobe Seizure Model.
Topics: Acute Disease; Algorithms; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Deep Brain Stimulation; Electric Stimulation; Epilepsy, Generalized; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Models, Neurological; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2019 |
Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats.
Topics: Animals; Anticonvulsants; Apoptosis; Carbamazepine; Caspase 9; Cognition; Drug Therapy, Combination; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Kainic Acid; Male; Maze Learning; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Seizures | 2019 |
Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.
Topics: Acetamides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lacosamide; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Signal Transduction; Status Epilepticus | 2019 |
Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cytokines; Dinoprostone; Disease Models, Animal; Gliosis; Hippocampus; Indoles; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Receptors, Prostaglandin E, EP2 Subtype; Seizures; Signal Transduction; Status Epilepticus | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Mice; Nerve Net; Pilocarpine; Seizures; Status Epilepticus | 2019 |
Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Recurrence; Seizures | 2019 |
[An Improved Method for Electroencephalographic Detection of Epileptic Discharge].
Topics: Animals; Electroencephalography; Epilepsy; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures | 2019 |
ALG13 Deficiency Associated with Increased Seizure Susceptibility and Severity.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mice; Mice, Knockout; N-Acetylglucosaminyltransferases; Neurons; Seizures; Severity of Illness Index; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation.
Topics: Adult; Animals; Convulsants; Epilepsy, Temporal Lobe; Female; Humans; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; MicroRNAs; Seizures | 2019 |
Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis.
Topics: Animals; Behavior, Animal; Epilepsy; Inositol; Kainic Acid; Seizures; Time Factors | 2019 |
Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Gyrus Cinguli; Hippocampus; Kainic Acid; Macaca mulatta; Magnetic Resonance Imaging; Male; Neurons; Neurosurgical Procedures; Robotic Surgical Procedures; Robotics; Seizures; Temporal Lobe | 2019 |
Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Female; Hippocampus; Kainic Acid; Magnolia; Male; Neurons; Neuroprotective Agents; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2019 |
[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures | 2019 |
Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy.
Topics: Animals; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Random Allocation; Seizures; Ultrasonic Therapy | 2019 |
P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
Topics: Angiogenesis Modulating Agents; Animals; Blood-Brain Barrier; Cells, Cultured; Epilepsy; Kainic Acid; Male; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Seizures; Signal Transduction; Smad2 Protein; Smad3 Protein; Thrombospondin 1; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2019 |
Immunohistochemical Study of Antioxidant Enzymes Regulated by Nrf2 in the Models of Epileptic Seizures (KA and PTZ).
Topics: Animals; Antioxidants; Behavior, Animal; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Models, Biological; NF-E2-Related Factor 2; Pentylenetetrazole; Rats, Wistar; Seizures | 2019 |
Partial depletion of septohippocampal cholinergic cells reduces seizure susceptibility, but does not mitigate hippocampal neurodegeneration in the kainate model of epilepsy.
Topics: Animals; Cholinergic Agents; Cholinergic Neurons; Disease Susceptibility; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Non-Neuronal Cholinergic System; Rats; Rats, Wistar; Saporins; Seizures; Status Epilepticus; Temporal Lobe | 2019 |
Neuroprotective effects of isoliquiritigenin against cognitive impairment via suppression of synaptic dysfunction, neuronal injury, and neuroinflammation in rats with kainic acid-induced seizures.
Topics: Animals; Anti-Inflammatory Agents; Chalcones; Cognitive Dysfunction; Encephalitis; Hippocampus; Inflammasomes; Kainic Acid; Male; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Rats, Wistar; Seizures; Synapses | 2019 |
Loss of ACOT7 potentiates seizures and metabolic dysfunction.
Topics: Adiposity; Animals; Behavior, Animal; Diet, High-Fat; Excitatory Amino Acid Agonists; Female; Glucose Intolerance; Kainic Acid; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Palmitoyl-CoA Hydrolase; Pregnancy; Seizures; Weight Gain | 2019 |
A pericyte-glia scarring develops at the leaky capillaries in the hippocampus during seizure activity.
Topics: Animals; Capillary Leak Syndrome; Cicatrix; Electroencephalography; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Pericytes; Seizures; Status Epilepticus | 2019 |
Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Hippocampus; Kainic Acid; Mice; Seizures; Synaptosomes | 2019 |
TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Hippocampus; Kainic Acid; Male; Neurons; Oxidative Stress; Phosphoric Monoester Hydrolases; Rats, Sprague-Dawley; Seizures | 2019 |
Long-lasting changes in hippocampal GABA
Topics: Amygdala; Animals; Excitatory Postsynaptic Potentials; Female; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Long-Evans; Receptors, GABA-B; Seizures; Temporal Lobe | 2019 |
Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling.
Topics: Animals; Anticonvulsants; Apoptosis; Brain-Derived Neurotrophic Factor; Dexmedetomidine; Drug Evaluation, Preclinical; Glutamic Acid; Hippocampus; Kainic Acid; Male; MAP Kinase Signaling System; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Receptor, trkB; Seizures | 2019 |
Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Female; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Microglia; Neurons; Seizures; Sex Factors | 2019 |
PLPP/CIN-mediated NEDD4-2 S448 dephosphorylation regulates neuronal excitability via GluA1 ubiquitination.
Topics: Animals; Humans; Kainic Acid; KCNQ Potassium Channels; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nedd4 Ubiquitin Protein Ligases; Neurons; Phosphates; Phosphoric Monoester Hydrolases; Receptors, AMPA; Seizures; Ubiquitination; Up-Regulation | 2019 |
The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pentylenetetrazole; Seizures | 2019 |
Ameliorative influence of Cnestis ferruginea vahl ex DC (Connaraceae) root extract on kainic acid-induced temporal lobe epilepsy in mice: Role of oxidative stress and neuroinflammation.
Topics: Animals; Anticonvulsants; Connaraceae; Cyclooxygenase 2; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Male; Medicine, African Traditional; Mice; NF-kappa B; Oxidative Stress; Plant Extracts; Plant Roots; Seizures | 2019 |
Lack of influence of prion protein gene expression on kainate-induced seizures in mice: studies using congenic, coisogenic and transgenic strains.
Topics: Animals; Gene Expression; Genetic Predisposition to Disease; Kainic Acid; Mice; Mice, Transgenic; Neurons; Prions; Seizures; Species Specificity | 2013 |
Increased excitability in tat-transgenic mice: role of tat in HIV-related neurological disorders.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Products, tat; Kainic Acid; Male; Mice; Mice, Transgenic; Nervous System Diseases; Neurotransmitter Agents; Seizures; Statistics, Nonparametric; tat Gene Products, Human Immunodeficiency Virus; Vesicular Glutamate Transport Proteins | 2013 |
Persistent neurological damage associated with spontaneous recurrent seizures and atypical aggressive behavior of domoic acid epileptic disease.
Topics: Aggression; Animals; Brain; Cell Count; Disease Models, Animal; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 2013 |
Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice.
Topics: Algorithms; Animals; Automation; Behavior, Animal; Brain Waves; Convulsants; Electroencephalography; False Negative Reactions; False Positive Reactions; Female; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Observer Variation; Seizures; Sensitivity and Specificity; Severity of Illness Index; Video Recording; Wavelet Analysis | 2013 |
Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures.
Topics: Animals; Cell Death; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; HMGB1 Protein; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neuropeptides; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Seizures; Toll-Like Receptor 4; Up-Regulation | 2013 |
Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy.
Topics: Age Factors; Animals; CA1 Region, Hippocampal; Gene Expression Profiling; Genetic Therapy; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures; Transcription, Genetic; Transcriptome | 2013 |
Possible protecting role of TNF-α in kainic acid-induced neurotoxicity via down-regulation of NFκB signaling pathway.
Topics: Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Knockout; Neurodegenerative Diseases; NF-kappa B; Seizures; Signal Transduction; Tumor Necrosis Factor-alpha | 2013 |
Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Topics: Animals; Fluoresceins; Granulins; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; Mice, Knockout; Neurotoxicity Syndromes; Neurotoxins; Nitro Compounds; Progranulins; Propionates; Quinolinic Acid; Seizures | 2013 |
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Topics: Adenosine Triphosphate; Animals; Antiporters; Brain; Calcium; Calcium-Binding Proteins; Cells, Cultured; Embryo, Mammalian; Female; Glucose; HEK293 Cells; Humans; Kainic Acid; Male; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Confocal; Microscopy, Electron; Mitochondria; Mitochondrial Proteins; Protons; RNA Interference; Seizures; Wolf-Hirschhorn Syndrome | 2013 |
Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment.
Topics: Animals; Astrocytes; Brain; Cell Death; Cell Nucleus; Hippocampus; Kainic Acid; Male; Neurons; Phosphorylation; Phosphoserine; Rats; Rats, Wistar; Ribosomal Protein S6; Seizures; Signal Transduction; Sirolimus; Spatio-Temporal Analysis; Status Epilepticus; Subcellular Fractions; TOR Serine-Threonine Kinases | 2013 |
Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in an animal seizure model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Neuronal Plasticity; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Synapses; Systemic Inflammatory Response Syndrome | 2013 |
Bupropion attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
Topics: Animals; Anticonvulsants; Bupropion; CA3 Region, Hippocampal; Cell Death; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Kainic Acid; Male; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Degeneration; Neurons; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Seizures | 2013 |
Seizure protection by intrapulmonary delivery of midazolam in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Routes; Kainic Acid; Male; Mice; Midazolam; Pentylenetetrazole; Picrotoxin; Seizures | 2013 |
Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Status Epilepticus; Transcription Factor AP-2 | 2013 |
Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Disease Susceptibility; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Piriform Cortex; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Seizures | 2013 |
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fragile X Mental Retardation Protein; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Synaptic Depression; Phosphorylation; Pregnancy; Protein Phosphatase 2; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ribosomal Protein S6 Kinases, 70-kDa; Seizures; Signal Transduction; Subcellular Fractions; Thiazoles | 2013 |
Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus.
Topics: Aging; Animals; Antibodies; Cytokines; Disease Models, Animal; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2013 |
Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Convulsants; Data Interpretation, Statistical; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Male; NAV1.1 Voltage-Gated Sodium Channel; NAV1.2 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2013 |
The effects of responsive and scheduled subicular high frequency stimulation in the intra-hippocampal kainic acid seizure model.
Topics: Animals; Data Interpretation, Statistical; Deep Brain Stimulation; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Microinjections; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2013 |
Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Brain; Disease Models, Animal; DNA Fragmentation; Exploratory Behavior; Kainic Acid; Male; Maze Learning; Mental Disorders; Motor Activity; Rats; Rats, Long-Evans; Rotarod Performance Test; Seizures | 2013 |
Notch signaling activation promotes seizure activity in temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cells, Cultured; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Humans; Kainic Acid; Male; Mice, Inbred C57BL; Organ Culture Techniques; Receptor, Notch1; Seizures; Signal Transduction | 2014 |
Effects of brain IKKβ gene silencing by small interfering RNA on P-glycoprotein expression and brain damage in the rat kainic acid-induced seizure model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Gene Expression; I-kappa B Kinase; Kainic Acid; Male; Neurons; NF-kappa B; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Seizures; Transcription, Genetic | 2014 |
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Neurons; Pilocarpine; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Status Epilepticus | 2013 |
Effects of rutin on oxidative stress in mice with kainic acid-induced seizure.
Topics: Animals; Dose-Response Relationship, Drug; Kainic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Rutin; Seizures; Sulfhydryl Compounds | 2013 |
Changes in the expression of GABAA receptor subunit mRNAs in parahippocampal areas after kainic acid induced seizures.
Topics: Animals; Down-Regulation; Hippocampus; Kainic Acid; Male; Parahippocampal Gyrus; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Status Epilepticus; Up-Regulation | 2013 |
Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus.
Topics: Amino Acid Transport System A; Amino Acid Transport Systems; Aminoisobutyric Acids; Animals; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Kainic Acid; Male; Microdialysis; Neurons; Rats; Rats, Wistar; Seizures | 2013 |
DNA methylation mediates persistent epileptiform activity in vitro and in vivo.
Topics: 5' Flanking Region; Animals; Cell Line; CpG Islands; DNA Methylation; Epilepsy; Gene Order; Genetic Association Studies; Hippocampus; Humans; Kainic Acid; Male; Membrane Potentials; Mice; Neurons; Phenotype; Phthalimides; Promoter Regions, Genetic; Rats; Receptors, AMPA; Seizures; Tryptophan | 2013 |
Certain secondary antiepileptic drugs can rescue hippocampal injury following a critical growth period despite poor anticonvulsant activity and cognitive deficits.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Body Weight; Brain Injuries; Cell Count; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Kainic Acid; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome | 2013 |
ADC mapping and T1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Convulsants; Diffusion Magnetic Resonance Imaging; Electroencephalography; Epilepsy, Post-Traumatic; Kainic Acid; Magnetic Resonance Imaging; Male; Prognosis; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Time Factors | 2014 |
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
Topics: Animals; Cerebral Cortex; Cytosol; Hippocampus; HSP72 Heat-Shock Proteins; Infusions, Subcutaneous; Kainic Acid; Lipid Peroxidation; Losartan; Male; Mitochondria; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar; Seizures; Superoxide Dismutase | 2014 |
High-frequency stimulation of the hippocampus protects against seizure activity and hippocampal neuronal apoptosis induced by kainic acid administration in macaques.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Biophysics; Caspase 3; Disease Models, Animal; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Macaca; Magnetic Resonance Imaging; Male; Neurons; Seizures | 2014 |
Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex.
Topics: Animals; Down-Regulation; Enzyme Inhibitors; Frontal Lobe; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Culture Techniques; Parietal Lobe; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Seizures | 2014 |
Both prolactin (PRL) and a molecular mimic of phosphorylated PRL, S179D-PRL, protect the hippocampus of female rats against excitotoxicity.
Topics: Amygdala; Animals; Arcuate Nucleus of Hypothalamus; Cell Death; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Kainic Acid; MAP Kinase Signaling System; Motor Activity; Neurons; Neuroprotective Agents; Prolactin; Rats; Rats, Wistar; Seizures; STAT5 Transcription Factor | 2014 |
Anticonvulsant and neuroprotective effects of oligosaccharides from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes).
Topics: Animals; Anticonvulsants; Behavior, Animal; Biological Products; Brain; Drugs, Chinese Herbal; Interleukin-1beta; Kainic Acid; Male; Mycelium; Neuroprotective Agents; Oligosaccharides; Rats; Rats, Wistar; Reishi; Seizures; Tumor Necrosis Factor-alpha | 2013 |
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
Topics: Adenosine Triphosphate; alpha-Tocopherol; Animals; Ascorbic Acid; Disease Models, Animal; Electric Stimulation; Electroencephalography; Electron Transport Complex I; Epilepsy, Temporal Lobe; Hippocampus; Hydrogen Peroxide; In Vitro Techniques; Kainic Acid; Kv1.1 Potassium Channel; Mice; Mice, Knockout; Mitochondria; Pyruvic Acid; Reactive Oxygen Species; Respiration; Seizures | 2014 |
Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Coenzyme A; Epilepsy, Temporal Lobe; Glutathione; Glutathione Disulfide; Hippocampus; Kainic Acid; Male; Mitochondria; Neurons; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Seizures; Severity of Illness Index; Time Factors; Tyrosine | 2014 |
Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.
Topics: Acute-Phase Reaction; Cytokines; Disease Susceptibility; Dose-Response Relationship, Drug; Exploratory Behavior; Gene Expression Regulation; Hippocampus; Illness Behavior; Inflammation; Kainic Acid; MicroRNAs; Molecular Mimicry; Nerve Tissue Proteins; Neuroimmunomodulation; Neurotoxins; Poly I-C; Receptors, Chemokine; Receptors, Cytokine; Seizures; Synaptic Transmission; Up-Regulation | 2014 |
[Expression of growth-associated protein 43 in the hippocampus of mesial temporal lobe epilepsy mouse model].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Mice; Seizures | 2013 |
Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility.
Topics: Animals; Brain; Cell Count; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Motor Activity; Neural Pathways; Otx Transcription Factors; Parvalbumins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Seizures | 2014 |
Decreased interaction between FoxO3a and Akt correlates with seizure-induced neuronal death.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 3; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-gamma; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Neurons; Oncogene Protein v-akt; Phosphopyruvate Hydratase; Phosphorylation; Proto-Oncogene Proteins; Seizures; Subcellular Fractions; Time Factors | 2014 |
Lestaurtinib (CEP-701) attenuates "second hit" kainic acid-induced seizures following early life hypoxic seizures.
Topics: Animals; Anticonvulsants; Carbazoles; Furans; Hippocampus; Hypoxia; Kainic Acid; Male; Phosphorylation; Rats; Rats, Long-Evans; Receptor, trkB; Seizures | 2014 |
Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-κB-mediated neuroinflammation in kainic acid-induced seizures.
Topics: Active Transport, Cell Nucleus; Animals; Aquaporin 4; Blood-Brain Barrier; CA3 Region, Hippocampal; Cell Line; Cell Nucleus; Cyclooxygenase 2; Haploinsufficiency; Kainic Acid; Male; Mice, Inbred ICR; NF-kappa B; Seizures; Transcription Factors; Vascular Endothelial Growth Factor A | 2014 |
Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death.
Topics: Animals; Anticonvulsants; Apoptosis; Cinnamates; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Hippocampus; Kainic Acid; Male; Mice, Inbred ICR; Mitochondria; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; Random Allocation; Seizures; Survival Analysis; Thiourea; Ubiquitin-Protein Ligases | 2014 |
Tolerance to seizure induced by kainic acid is produced in a specific period of zebrafish development.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraperitoneal; Kainic Acid; Motor Activity; Seizures; Zebrafish | 2014 |
N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.
Topics: Animals; beta Catenin; Cadherins; Dendrites; Dendritic Spines; Disks Large Homolog 4 Protein; Guanylate Kinases; Hippocampus; Kainic Acid; Male; Membrane Proteins; Memory Disorders; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neurons; Prosencephalon; Receptors, AMPA; Seizures; Spatial Memory; Synapses | 2014 |
Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia.
Topics: Alternative Splicing; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Calcium-Binding Proteins; Cells, Cultured; Chemotaxis; Excitatory Amino Acid Agonists; Hippocampus; Interleukin-6; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Neurons; Proto-Oncogene Proteins c-fos; Receptor, Anaphylatoxin C5a; RNA, Messenger; Seizures; Tumor Necrosis Factor-alpha | 2014 |
Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures.
Topics: Animals; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Kainic Acid; Long-Term Synaptic Depression; MAP Kinase Signaling System; Membrane Potentials; Proteasome Endopeptidase Complex; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ribosomal Protein S6 Kinases; Seizures; Signal Transduction; Synapses; Tissue Culture Techniques; TOR Serine-Threonine Kinases | 2014 |
Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice.
Topics: Animals; Brain; Female; Genes, Reporter; Gliosis; Green Fluorescent Proteins; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; NF-kappa B; Pyramidal Cells; Seizures; Signal Transduction | 2014 |
3-Methyl-1-phenyl-2-pyrazolin-5-one or N-acetylcysteine prevents hippocampal mossy fiber sprouting and rectifies subsequent convulsive susceptibility in a rat model of kainic acid-induced seizure ceased by pentobarbital.
Topics: Acetylcysteine; Aldehydes; Animals; Anticonvulsants; Antipyrine; Cell Survival; Edaravone; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Glutathione; Kainic Acid; Male; Mossy Fibers, Hippocampal; Pentobarbital; Rats; Rats, Sprague-Dawley; Seizures | 2014 |
The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions.
Topics: Animals; Astrocytes; Cell Proliferation; Central Nervous System Agents; Disease Models, Animal; Hedgehog Proteins; Hippocampus; Kainic Acid; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Neurogenesis; Neurons; Seizures; Severity of Illness Index; Signal Transduction; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2014 |
Synergic effect of exercise and lipoic acid on protection against kainic acid induced seizure activity and oxidative stress in mice.
Topics: Animals; Combined Modality Therapy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Oxidative Stress; Physical Conditioning, Animal; Random Allocation; Seizures; Thioctic Acid | 2014 |
Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
Topics: Adamantane; Amines; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intramuscular; Kainic Acid; Male; Memantine; N-Methylaspartate; Neuroprotective Agents; Pentylenetetrazole; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Analysis | 2014 |
DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity.
Topics: Animals; Chelating Agents; Dendritic Spines; Egtazic Acid; Hippocampus; Kainic Acid; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Seizures | 2014 |
Glycyrrhizin suppresses HMGB1 inductions in the hippocampus and subsequent accumulation in serum of a kainic acid-induced seizure mouse model.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Models, Animal; Endothelial Cells; Glycyrrhizic Acid; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Mice, Inbred BALB C; Neuroglia; Neurons; Protein Transport; Seizures | 2014 |
Evaluation of the neuroprotective activity of stansin 6, a resin glycoside from Ipomoea stans.
Topics: Animals; Anticonvulsants; Dogs; Dose-Response Relationship, Drug; Glycolipids; Hippocampus; Ipomoea; Kainic Acid; Molecular Conformation; Neuroprotective Agents; Plant Roots; Rats; Seizures; Structure-Activity Relationship | 2014 |
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice.
Topics: Animals; Anticonvulsants; Benzofurans; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Histamine H3 Antagonists; Kainic Acid; Male; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Pyrrolidines; Random Allocation; Seizures; Thiadiazoles; Valproic Acid | 2014 |
3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility.
Topics: Animals; Astrocytes; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Gliosis; Hallucinogens; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Microglia; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Random Allocation; Seizures | 2014 |
Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice.
Topics: Animals; Autoradiography; Disease Models, Animal; Epilepsy, Temporal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kainic Acid; Male; Mice; Neocortex; Neuropeptide Y; Peptide YY; Receptors, Neuropeptide Y; RNA, Messenger; Seizures; Time Factors | 2014 |
Retigabine calms seizure-induced behavior following status epilepticus.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carbamates; Convulsants; Hippocampus; Hyperkinesis; Kainic Acid; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2014 |
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.
Topics: Aging; Animals; Arachidonic Acids; Endocannabinoids; Glycerides; Hippocampus; Kainic Acid; Neurons; Polyunsaturated Alkamides; Rats; Seizures | 2014 |
[Effects of hippocampal stimulus on α₅ subunit of extrasynaptic GABA(A) receptor in kainic acid-induced epileptic rats].
Topics: Animals; Electric Stimulation; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2014 |
Decursin attenuates kainic acid-induced seizures in mice.
Topics: Animals; Benzopyrans; Butyrates; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fos; Seizures | 2014 |
Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid.
Topics: Animals; Biotinylation; Brain; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Female; Gene Expression Regulation; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Knockout; Mitochondrial Proteins; Neurons; Seizures; Sirtuins; Synaptosomes | 2014 |
Synthesis, anticonvulsant properties, and SAR analysis of differently substituted pyrrolidine-2,5-diones and piperidine-2,6-diones.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Drug Design; Electric Stimulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Molecular Structure; Neuroprotective Agents; Pentylenetetrazole; Piperidones; Seizures; Structure-Activity Relationship; Succinimides; Time Factors | 2014 |
Raloxifene protects against seizures and neurodegeneration in a mouse model mimicking epilepsy in postmenopausal woman.
Topics: Animals; Bone Density; Cyclohexenes; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Neurodegenerative Diseases; Neurons; Postmenopause; Raloxifene Hydrochloride; Seizures; Transforming Growth Factor beta3; Vinyl Compounds | 2014 |
Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice.
Topics: Animals; Blood Glucose; CA3 Region, Hippocampal; Cell Death; Cholera Toxin; Corticosterone; Hyperglycemia; Hypoglycemia; Infusions, Intraventricular; Insulin; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Pertussis Toxin; Seizures | 2014 |
BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain-Derived Neurotrophic Factor; Calpain; Chlorides; Disease Models, Animal; Hippocampus; K Cl- Cotransporters; Kainic Acid; Mice, Knockout; Neurons; Seizures; Status Epilepticus; Symporters; Tissue Culture Techniques; Up-Regulation | 2015 |
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Topics: Adenosine Kinase; Animals; Astrocytes; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Gene Targeting; Genetic Therapy; Genetic Vectors; Glutamate-Ammonia Ligase; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Transgenes | 2014 |
Domoic acid-induced seizures in California sea lions (Zalophus californianus) are associated with neuroinflammatory brain injury.
Topics: Animals; Brain Injuries; Glutamate-Ammonia Ligase; Kainic Acid; Neurons; Oxidative Stress; Sea Lions; Seizures; Water Pollutants, Chemical | 2014 |
Susceptibility to seizure-induced excitotoxic cell death is regulated by an epistatic interaction between Chr 18 (Sicd1) and Chr 15 (Sicd2) loci in mice.
Topics: Animals; Behavior, Animal; Cell Death; Chromosomes, Mammalian; Disease Models, Animal; Epistasis, Genetic; Genetic Loci; Genotype; Hippocampus; Kainic Acid; Mice; Microsatellite Repeats; Neurons; Phenotype; Physical Chromosome Mapping; Quantitative Trait Loci; Seizures | 2014 |
Neuroprotective effects of trans-caryophyllene against kainic acid induced seizure activity and oxidative stress in mice.
Topics: Animals; Antioxidants; Brain Chemistry; Cytokines; Excitatory Amino Acid Agonists; Kainic Acid; Lipid Peroxidation; Mice; Neuroprotective Agents; Oxidative Stress; Polycyclic Sesquiterpenes; Seizures; Sesquiterpenes | 2015 |
Activation of AKT/GSK3β pathway by TDZD-8 attenuates kainic acid induced neurodegeneration but not seizures in mice.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain; Caspase 3; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Kainic Acid; Male; Mice; Neurodegenerative Diseases; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; Seizures; Signal Transduction; Thiadiazoles | 2015 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Ethanol; Female; Kainic Acid; Mice; Nordazepam; Oxazepam; Seizures; Solvents; Temazepam; Water | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Levetiracetam; Mice; Phenobarbital; Phenytoin; Piracetam; Seizures; Valproic Acid | 2015 |
Prosaposin overexpression following kainic acid-induced neurotoxicity.
Topics: Animals; Cerebral Cortex; Choroid Plexus; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Interneurons; Kainic Acid; Lysosomes; Male; Microscopy, Fluorescence; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Rats; Rats, Wistar; Saposins; Seizures; Up-Regulation | 2014 |
Suppression of adult neurogenesis increases the acute effects of kainic acid.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Electroencephalography; Ethosuximide; Excitatory Amino Acid Agonists; Ganciclovir; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuropeptides; Seizures; Thymidine Kinase; Valganciclovir; X-Rays | 2015 |
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.
Topics: Acute Disease; Animals; Bumetanide; Chronic Disease; Corticosterone; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; K Cl- Cotransporters; Kainic Acid; Male; Membrane Potentials; Mice, Inbred C57BL; Phosphorylation; Pyramidal Cells; Restraint, Physical; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2; Stress, Psychological; Symporters | 2015 |
Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood.
Topics: Animals; Animals, Newborn; Atrophy; Corpus Callosum; Diffusion Tensor Imaging; Disease Models, Animal; Female; Hippocampus; Hyperthermia, Induced; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Neural Pathways; Pentylenetetrazole; Rats, Sprague-Dawley; Seizures | 2015 |
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.
Topics: Action Potentials; Animals; Animals, Newborn; Disease Models, Animal; Edetic Acid; Excitatory Amino Acid Agonists; Fluoresceins; Gamma Rhythm; Gene Expression Regulation; Hippocampus; Homeostasis; In Vitro Techniques; K Cl- Cotransporters; Kainic Acid; Mice; Mice, Transgenic; Protein Transport; Receptors, G-Protein-Coupled; Seizures; Statistics, Nonparametric; Symporters; Zinc | 2015 |
Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzodiazepines; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Protein Subunits; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 2015 |
Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Cells, Cultured; High-Throughput Screening Assays; Hippocampus; Kainic Acid; Lamotrigine; Mice, Inbred C57BL; Muscarinic Agonists; Nerve Net; Neurons; Potassium Channel Blockers; Receptors, Kainic Acid; Seizures; Triazines | 2015 |
Blocking miRNA Biogenesis in Adult Forebrain Neurons Enhances Seizure Susceptibility, Fear Memory, and Food Intake by Increasing Neuronal Responsiveness.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Conditioning, Classical; DEAD-box RNA Helicases; Fear; Female; Hyperphagia; Kainic Acid; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Neuronal Plasticity; Neurons; Phenotype; Prosencephalon; Ribonuclease III; Seizures; Sequence Analysis, RNA | 2016 |
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Brain; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Humans; Kainic Acid; Male; Malondialdehyde; Mice, Knockout; Mice, Transgenic; Oxidative Stress; Pentylenetetrazole; Presenilin-1; Seizures; Sodium-Coupled Vitamin C Transporters | 2015 |
Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype.
Topics: Age Factors; Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures; Social Behavior | 2015 |
Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats.
Topics: Animals; Disease Models, Animal; Electroencephalography; Glutamic Acid; Hippocampus; Housing, Animal; Kainic Acid; Male; Random Allocation; Rats, Sprague-Dawley; Running; Seizures; Telemetry | 2015 |
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Knockout; Microglia; Neurons; Peptides, Cyclic; Pilocarpine; Receptor, Anaphylatoxin C5a; Seizures; Tumor Necrosis Factor-alpha | 2015 |
Key proteins of activating cell death can be predicted through a kainic acid-induced excitotoxic stress.
Topics: Animals; Apoptosis; Biomarkers; Cell Death; Epilepsy; Kainic Acid; Necrosis; Neurons; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Seizures; Stress, Physiological | 2015 |
Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; CA3 Region, Hippocampal; Cell Death; Cytokines; Flavones; Kainic Acid; Male; Microglia; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2015 |
Attenuation of kainic acid-induced status epilepticus by inhibition of endocannabinoid transport and degradation in guinea pigs.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Benzamides; Biological Transport; Brain; Cannabinoid Receptor Antagonists; Carbamates; Endocannabinoids; Guinea Pigs; Kainic Acid; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus | 2015 |
Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.
Topics: Animals; Carrier Proteins; Dronabinol; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyramidal Cells; Receptor, Cannabinoid, CB1; RNA, Messenger; Seizures; Signal Transduction | 2016 |
Synthesis, structure-activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists.
Topics: Animals; Anticonvulsants; Antinematodal Agents; Cells, Cultured; Electroshock; Hippocampus; Kainic Acid; Mice; Neurons; Pyridines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Thiazines | 2015 |
Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety.
Topics: Acid Sensing Ion Channels; Amphetamine; Animals; Anxiety; Body Composition; Eating; Estrogen Antagonists; Excitatory Amino Acid Agonists; Fear; Humans; Hyperkinesis; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nervous System; Nociception; Seizures; Tamoxifen; Time Factors | 2015 |
Protective effects of bupivacaine against kainic acid-induced seizure and neuronal cell death in the rat hippocampus.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Behavior, Animal; Bupivacaine; CA3 Region, Hippocampal; Cell Death; Interleukin-1beta; Interleukin-6; Kainic Acid; Male; Maze Learning; Microglia; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Tumor Necrosis Factor-alpha | 2015 |
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Mice; Nitriles; Phenytoin; Pyridones; Quinoxalines; Receptors, AMPA; Seizures; Status Epilepticus | 2015 |
[Effect of licorice flavonoids on kainic acid-induced seizure in mice].
Topics: Animals; Disease Models, Animal; Flavonoids; Glycyrrhiza; Kainic Acid; Male; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Neurogenesis; Seizures; Status Epilepticus | 2015 |
A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury.
Topics: Animals; Behavior, Animal; Brain Edema; Catechin; Cyclooxygenase Inhibitors; Dinoprostone; Drug Combinations; Hippocampus; Kainic Acid; Leukotriene B4; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Malondialdehyde; MAP Kinase Signaling System; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Phosphorylation; Protein Processing, Post-Translational; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures; Tumor Necrosis Factor-alpha | 2015 |
Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Seizures; Social Behavior; Status Epilepticus; Ultrasonography, Interventional | 2015 |
Maternal immune activation increases seizure susceptibility in juvenile rat offspring.
Topics: Animals; Animals, Newborn; Anxiety; Brain Injuries; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures | 2015 |
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Apoptosis; CA3 Region, Hippocampal; Child; Child, Preschool; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Kainic Acid; Kindling, Neurologic; Male; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; RNA Interference; Seizures; Young Adult | 2015 |
Epileptogenesis following Kainic Acid-Induced Status Epilepticus in Cyclin D2 Knock-Out Mice with Diminished Adult Neurogenesis.
Topics: Amygdala; Animals; Cyclin D2; Doublecortin Protein; Electroencephalography; Kainic Acid; Mice; Mice, Knockout; Neurogenesis; Seizures; Status Epilepticus | 2015 |
TLR1 expression in mouse brain was increased in a KA-induced seizure model.
Topics: Animals; Astrocytes; Brain Chemistry; CA1 Region, Hippocampal; Dentate Gyrus; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred C57BL; Microglia; Neurons; Polymerase Chain Reaction; RNA, Messenger; Seizures; Toll-Like Receptor 1; Up-Regulation | 2015 |
Potent anti-seizure effects of D-leucine.
Topics: Animals; Anticonvulsants; Kainic Acid; Leucine; Long-Term Potentiation; Male; Mice; Seizures; Synaptic Transmission; Treatment Outcome | 2015 |
Matrix Metalloproteinase-9 Regulates Neuronal Circuit Development and Excitability.
Topics: Animals; Animals, Newborn; Biomarkers; Cell Death; Dendritic Spines; Female; Hippocampus; Kainic Acid; Male; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Nerve Net; Neurons; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Seizures; Synapses; Synaptic Transmission | 2016 |
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
Topics: Animals; Cyclic N-Oxides; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Kainic Acid; Lipopolysaccharides; Microglia; Nitrobenzenes; Oxidative Stress; Rats; Seizures; Spin Labels; Sulfonamides; Tumor Necrosis Factor-alpha | 2015 |
Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.
Topics: Animals; Autistic Disorder; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Hippocampus; Interleukin-1beta; Interleukin-6; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Pregnancy; Seizures; Status Epilepticus | 2015 |
Cav3.1 T-type calcium channel modulates the epileptogenicity of hippocampal seizures in the kainic acid-induced temporal lobe epilepsy model.
Topics: Animals; Calcium Channels, T-Type; Cerebral Cortex; Delta Rhythm; Disease Models, Animal; Electrocorticography; Electrodes, Implanted; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Seizures; Status Epilepticus; Time Factors | 2015 |
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Neurofeedback; Potassium Channel Blockers; Rats; Seizures | 2015 |
Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.
Topics: Animals; Biomarkers; Cell Death; Cell Line; Cytokines; Disease Models, Animal; Gene Expression; Genetic Predisposition to Disease; Gliosis; Hippocampus; Inflammation Mediators; Kainic Acid; Mice; Mice, Knockout; PrPC Proteins; Seizures; Transfection | 2015 |
[Changes over time of cannabinoid receptor 1 in hippocampus of status epilepticus rats].
Topics: Animals; Cannabinoids; Hippocampus; Kainic Acid; Rats; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus | 2015 |
Glycine transporter 1 is a target for the treatment of epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Dioxoles; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Glycine Plasma Membrane Transport Proteins; Hippocampus; Humans; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Rats, Sprague-Dawley; Seizures | 2015 |
Acute reduction of neuronal RNA binding Elavl2 protein and Gap43 mRNA in mouse hippocampus after kainic acid treatment.
Topics: Animals; CA3 Region, Hippocampal; ELAV-Like Protein 2; Excitatory Amino Acid Agonists; GAP-43 Protein; Gene Expression Regulation; Interneurons; Kainic Acid; Male; Mice; Pyramidal Cells; RNA, Messenger; Seizures | 2015 |
M-current preservation contributes to anticonvulsant effects of valproic acid.
Topics: A Kinase Anchor Proteins; Action Potentials; Animals; Anthracenes; Anticonvulsants; Carbamates; Cells, Cultured; Drug Interactions; Female; Hippocampus; Humans; Kainic Acid; KCNQ2 Potassium Channel; Lipoylation; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Protein Processing, Post-Translational; Rats; Receptor, Muscarinic M1; Recombinant Fusion Proteins; Seizures; Signal Transduction; Superior Cervical Ganglion; Valproic Acid | 2015 |
Houttuyniae Herba Attenuates Kainic Acid-Induced Neurotoxicity via Calcium Response Modulation in the Mouse Hippocampus.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Disease Models, Animal; Hippocampus; Houttuynia; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Seizures | 2015 |
On the anticonvulsant effect of allopregnanolone (a neurosteroid) in neonatal rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Kainic Acid; Male; Pregnanolone; Rats; Rats, Wistar; Seizures; Treatment Outcome | 2015 |
Altered taste preference and loss of limbic-projecting serotonergic neurons in the dorsal raphe nucleus of chronically epileptic rats.
Topics: Anhedonia; Animals; Cell Count; Chronic Disease; Depressive Disorder; Disease Models, Animal; Dorsal Raphe Nucleus; Electrocorticography; Epilepsy; Immunohistochemistry; Kainic Acid; Male; Random Allocation; Rats, Wistar; Seizures; Serotonergic Neurons; Status Epilepticus; Taste Perception | 2016 |
High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death.
Topics: Animals; Cell Death; Diet, High-Fat; Excitatory Amino Acid Agonists; Fatty Liver; Hippocampus; Hypercholesterolemia; In Situ Nick-End Labeling; Inflammation; Insulin Resistance; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Obesity; Oxidative Stress; Seizures | 2015 |
Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.
Topics: Animals; Aspartic Acid; Astrocytes; Benzodiazepines; Biogenic Polyamines; Calcium; Cerebral Cortex; Enzyme Induction; Genetic Predisposition to Disease; Gliosis; Hippocampus; Kainic Acid; Male; Metallothionein; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Neurotoxins; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Receptors, AMPA; Recombinant Fusion Proteins; Seizures; Synaptosomes; Up-Regulation | 2016 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Protein Serine-Threonine Kinases; RNA, Messenger; Seizures; Signal Transduction | 2016 |
Forebrain-independent generation of hyperthermic convulsions in infant rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Denervation; Diazepam; Disease Models, Animal; Excitatory Amino Acid Agonists; Hyperthermia, Induced; Kainic Acid; Male; Prosencephalon; Rats; Rats, Wistar; Seizures; Time Factors | 2016 |
Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase Type II; Seizures | 2015 |
Combined Low-Intensity Exercise and Ascorbic Acid Attenuates Kainic Acid-Induced Seizure and Oxidative Stress in Mice.
Topics: Animals; Ascorbic Acid; Kainic Acid; Male; Mice, Inbred ICR; Oxidative Stress; Physical Conditioning, Animal; Seizures | 2016 |
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Topics: Adenylyl Cyclases; Animals; Cell Death; Convulsants; Disease Models, Animal; Hippocampus; Kainic Acid; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Pilocarpine; Seizures; Status Epilepticus | 2016 |
Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Bumetanide; Diazepam; Disease Progression; Drug Resistant Epilepsy; Electroencephalography; Entorhinal Cortex; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Status Epilepticus | 2016 |
Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure.
Topics: Acute Disease; Animals; Animals, Newborn; Blotting, Western; CA1 Region, Hippocampal; Disease Models, Animal; Excitatory Postsynaptic Potentials; Kainic Acid; Long-Term Potentiation; Male; Patch-Clamp Techniques; Phosphorylation; Pyramidal Cells; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Time; Tissue Culture Techniques | 2016 |
Pre- and post-exposure talampanel (GYKI 53773) against kainic acid seizures in neonatal rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 2016 |
Mechanisms of tau and Aβ-induced excitotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cerebral Cortex; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Neurons; Rats; Reactive Oxygen Species; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Seizures; Superoxides; tau Proteins | 2016 |
Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats.
Topics: Animals; Calcium-Binding Proteins; Cardiovascular Abnormalities; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gamma Rhythm; Kainic Acid; Male; Medulla Oblongata; Microfilament Proteins; Microglia; Minocycline; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures; Splanchnic Nerves; Tyrosine 3-Monooxygenase; Vagotomy | 2016 |
Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid.
Topics: Analysis of Variance; Animals; Brain Waves; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Phosphopyruvate Hydratase; Piperazines; Rats; Rats, Wistar; Ritanserin; Seizures; Serotonin Antagonists | 2016 |
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Seizures; Time Factors; Urate Oxidase; Uric Acid; Video Recording | 2016 |
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures.
Topics: Animals; Astrocytes; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Metabotropic Glutamate 5; Seizures; Status Epilepticus | 2016 |
Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fourier Analysis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures; Time Factors; Treatment Outcome | 2016 |
Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations.
Topics: Animals; Carbamates; Gene Knock-In Techniques; Humans; Ion Channel Gating; Kainic Acid; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Models, Molecular; Mutation; Phenylenediamines; Protein Structure, Tertiary; Seizures | 2016 |
Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Forkhead Transcription Factors; Glucosides; Glutathione; Hippocampus; Kainic Acid; Male; Malondialdehyde; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Oxidative Stress; Phenols; Seizures; Sirtuin 1; Status Epilepticus; Superoxide Dismutase | 2016 |
PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Clonazepam; Excitatory Amino Acid Agonists; GABA Modulators; Grooming; GTPase-Activating Proteins; Jacobsen Distal 11q Deletion Syndrome; Kainic Acid; Mice; Mice, Knockout; Olfactory Perception; Protein Transport; Receptors, GABA-A; Seizures; Social Behavior; Stereotyped Behavior; Vocalization, Animal | 2016 |
Neuroprotective and anti-inflammatory effects of lidocaine in kainic acid-injected rats.
Topics: Animals; Anti-Inflammatory Agents; CA3 Region, Hippocampal; Cell Death; Encephalitis; Kainic Acid; Lidocaine; Male; Microglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2016 |
Leukocyte Infiltration Triggers Seizure Recurrence in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Kainic Acid; Leukocytes; Neurons; Rats; Recurrence; Seizures | 2016 |
Stimulation of Anterior Thalamic Nuclei Protects Against Seizures and Neuronal Apoptosis in Hippocampal CA3 Region of Kainic Acid-induced Epileptic Rats.
Topics: Animals; Anterior Thalamic Nuclei; Apoptosis; Deep Brain Stimulation; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2016 |
Immediate epileptogenesis: Impact on brain in C57BL/6J mouse kainate model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Immunohistochemistry; Kainic Acid; Male; Mice, Inbred C57BL; Seizures; Statistics, Nonparametric; Status Epilepticus | 2016 |
Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; CA1 Region, Hippocampal; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy, Post-Traumatic; Kainic Acid; Levetiracetam; Male; Neurons; Neuroprotective Agents; Piracetam; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Time Factors | 2016 |
Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures.
Topics: Analysis of Variance; Animals; Astrocytes; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Interleukins; Kainic Acid; Mice; Mice, Inbred C57BL; Phosphopyruvate Hydratase; RNA, Messenger; Seizures; Time Factors | 2016 |
Kainic acid-induced albumin leak across the blood-brain barrier facilitates epileptiform hyperexcitability in limbic regions.
Topics: Albumins; Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Guinea Pigs; Interleukin-1beta; Kainic Acid; Limbic System; Microscopy, Confocal; Phosphopyruvate Hydratase; Seizures; Serum Albumin; Spectrum Analysis; Subcellular Fractions | 2016 |
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Mice; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neuroglia; Neurons; Pentylenetetrazole; Seizures | 2016 |
Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats.
Topics: Animals; CD11b Antigen; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Hippocampus; Kainic Acid; Luteolin; Male; Maze Learning; Microscopy, Electron, Transmission; Mitochondria; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2016 |
Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation.
Topics: Acetylation; Animals; Anticonvulsants; Apoptosis; CA1 Region, Hippocampal; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kainic Acid; Male; Microglia; Myeloid Differentiation Factor 88; Neurons; Random Allocation; Rats, Sprague-Dawley; Seizures; Signal Transduction; Toll-Like Receptor 4; Vorinostat | 2016 |
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Topics: Adenosine Triphosphate; Adult; Animals; Apoptosis; CX3C Chemokine Receptor 1; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Leukocyte Common Antigens; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Monocytes; Neurons; Phagocytosis; Receptors, CCR2; Receptors, Chemokine; Seizures | 2016 |
Protective role of miR-23b-3p in kainic acid-induced seizure.
Topics: Animals; Cerebral Cortex; Kainic Acid; Mice, Inbred C57BL; MicroRNAs; Primary Cell Culture; Seizures | 2016 |
Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure.
Topics: Animals; CA1 Region, Hippocampal; Cognitive Dysfunction; Disease Models, Animal; Female; Genistein; Kainic Acid; Long-Term Potentiation; Memory, Short-Term; Neuronal Plasticity; Ovariectomy; Rats; Rats, Wistar; Seizures; Spatial Learning | 2016 |
Apolipoprotein D Overexpression Protects Against Kainate-Induced Neurotoxicity in Mice.
Topics: Animals; Apolipoproteins D; Apoptosis; Astrocytes; Cholesterol; Endocytosis; Hippocampus; Humans; Inflammation; Kainic Acid; Mice, Transgenic; Models, Biological; Neurons; Neuroprotection; Neurotoxins; Plasma Membrane Calcium-Transporting ATPases; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Seizures; Up-Regulation | 2017 |
Involvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity.
Topics: Animals; Kainic Acid; Mice; Neurons; Phosphotyrosine; Seizures; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 3 | 2016 |
A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death.
Topics: Animals; Calcium-Binding Proteins; Cell Death; Cyclooxygenase 2; Disease Models, Animal; Dynamins; Hippocampus; HSP72 Heat-Shock Proteins; Kainic Acid; Male; Mice, Inbred ICR; Microfilament Proteins; Mitochondria; Mitochondrial Dynamics; Mitophagy; Neuroglia; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Quinazolinones; Random Allocation; Seizures; Survival Analysis; Ubiquitin-Protein Ligases | 2016 |
Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Female; Gene Expression; Gene Knockout Techniques; Humans; Kainic Acid; Lithium; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Transgenic; Neurogenesis; Neurons; Phenotype; Phosphorylation; Protein Interaction Domains and Motifs; Receptors, N-Methyl-D-Aspartate; Seizures; tau Proteins | 2016 |
Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model.
Topics: Animals; Anticonvulsants; Combined Modality Therapy; Disease Models, Animal; Kainic Acid; Lorazepam; Rats; Seizures; Status Epilepticus; Transcranial Magnetic Stimulation; Treatment Outcome | 2016 |
Expressions of CCAAT/enhancer-binding Protein Homologous Protein and Calnexin in the Hippocampus of a Mouse Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Calnexin; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Seizures; Transcription Factor CHOP | 2016 |
The ability of anterior thalamic signals to predict seizures in temporal lobe epilepsy in kainate-treated rats.
Topics: Algorithms; Animals; Anterior Thalamic Nuclei; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Time Factors | 2016 |
MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures.
Topics: Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cells, Cultured; Disease Models, Animal; Flurothyl; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Microarray Analysis; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Transcriptome | 2016 |
Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model.
Topics: Acoustic Stimulation; Action Potentials; Angelman Syndrome; Animals; Conditioning, Psychological; Disease Models, Animal; Esters; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Female; Hippocampus; Kainic Acid; Ketones; Male; Maze Learning; Mice; Mice, Transgenic; Neuronal Plasticity; Psychomotor Performance; Seizures; Ubiquitin-Protein Ligases | 2016 |
Dynamic causal modelling of seizure activity in a rat model.
Topics: Animals; Bayes Theorem; Epilepsy; Hippocampus; Kainic Acid; Models, Neurological; Neurons; Rats, Wistar; Seizures; Signal Processing, Computer-Assisted | 2017 |
Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure-Induced Behavioral Abnormalities.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anxiety; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Gene Expression Regulation; Homeodomain Proteins; Kainic Acid; Maze Learning; Mechanistic Target of Rapamycin Complex 1; Mental Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Nestin; Nuclear Proteins; Regulatory-Associated Protein of mTOR; Repressor Proteins; Seizures; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset.
Topics: Animals; Antagomirs; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Neurons; Primary Cell Culture; RNA-Induced Silencing Complex; Seizures; Shal Potassium Channels; Signal Transduction; Status Epilepticus | 2016 |
MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.
Topics: Animals; Body Temperature; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamate Decarboxylase; Glutamic Acid; Hallucinogens; Hippocampus; Kainic Acid; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Up-Regulation | 2016 |
Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Epilepsy; Haploinsufficiency; Kainic Acid; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mutation; Neurons; PTEN Phosphohydrolase; Seizures; Social Behavior; Status Epilepticus | 2016 |
Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model.
Topics: Animals; Brain; Death, Sudden; Disease Models, Animal; Heart Arrest; Hypoxia; Ischemia; Kainic Acid; Laryngeal Nerves; Laryngismus; Male; Movement; Rats, Sprague-Dawley; Seizures; Sleep Apnea, Central; Sleep Apnea, Obstructive; Vocal Cords | 2016 |
Effective G-protein coupling of Y2 receptors along axonal fiber tracts and its relevance for epilepsy.
Topics: Animals; Axons; GTP-Binding Proteins; Hippocampus; Kainic Acid; Male; Nerve Fibers; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Seizures; Synaptophysin; Tubulin | 2017 |
Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Topics: Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Status Epilepticus; Time Factors | 2016 |
Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cells, Cultured; Dendrites; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Neurons; Protein Processing, Post-Translational; Purkinje Cells; Seizures; Tubulin | 2017 |
Effect of tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats.
Topics: Animals; Antioxidants; Brain; Cerebral Cortex; Honey; Humans; Kainic Acid; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures | 2017 |
CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Benzylamines; Chemokine CXCL12; Cognition Disorders; Cyclams; Disease Models, Animal; Epilepsy, Temporal Lobe; Heterocyclic Compounds; Hippocampus; Housing, Animal; Kainic Acid; Male; Neurogenesis; Neurons; Random Allocation; Rats, Wistar; Receptors, CXCR4; Seizures | 2017 |
Everolimus is better than rapamycin in attenuating neuroinflammation in kainic acid-induced seizures.
Topics: Animals; Convulsants; Everolimus; Immunosuppressive Agents; Inflammation; Kainic Acid; Mice; Microglia; Seizures; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Acute and spontaneous seizure onset zones in the intraperitoneal kainic acid model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2017 |
Seizure-associated central apnea in a rat model: Evidence for resetting the respiratory rhythm and activation of the diving reflex.
Topics: Animals; Brain; Disease Models, Animal; Diving Reflex; Electrocardiography; Electroencephalography; Heart Rate; Kainic Acid; Male; Plethysmography; Rats, Sprague-Dawley; Respiration; Seizures; Sleep Apnea, Central | 2017 |
Various modifications of the intrahippocampal kainate model of mesial temporal lobe epilepsy in rats fail to resolve the marked rat-to-mouse differences in type and frequency of spontaneous seizures in this model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Rats; Seizures; Species Specificity; Status Epilepticus | 2017 |
Hippocampal infusion of lipopolysaccharide induces immune responses and results in seizures in rats.
Topics: Animals; Astrocytes; Excitatory Amino Acid Agonists; Hippocampus; Immunity, Innate; Kainic Acid; Lipopolysaccharides; Male; Neurons; Rats, Wistar; Seizures | 2017 |
Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs.
Topics: Amygdala; Animals; Brain; Dentate Gyrus; Endocannabinoids; Guinea Pigs; Hippocampus; Kainic Acid; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Status Epilepticus | 2017 |
Peripheral viral challenge elevates extracellular glutamate in the hippocampus leading to seizure hypersusceptibility.
Topics: Acute-Phase Reaction; Animals; Body Weight; CA1 Region, Hippocampal; Electrodes, Implanted; Excitatory Amino Acid Agonists; Extracellular Space; Female; Glutamates; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Peripheral Nervous System Diseases; Poly I-C; Seizures; Status Epilepticus | 2017 |
Seizure termination by acidosis depends on ASIC1a.
Topics: Acid Sensing Ion Channels; Acidosis; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Carbon Dioxide; Electroencephalography; Female; Hippocampus; Hydrogen-Ion Concentration; Interneurons; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Knockout; Nerve Tissue Proteins; Patch-Clamp Techniques; Pentylenetetrazole; Picrotoxin; Seizures; Sodium Channels; Time Factors | 2008 |
Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death.
Topics: Analysis of Variance; Animals; Benzoquinones; Carbazoles; Cell Death; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Indole Alkaloids; Kainic Acid; Lactams, Macrocyclic; Limbic System; Male; Mossy Fibers, Hippocampal; Nerve Growth Factors; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Rifabutin; Seizures; Statistics, Nonparametric | 2008 |
Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures.
Topics: Animals; Behavior, Animal; Bisbenzimidazole; Cell Line, Transformed; Chromatography, High Pressure Liquid; Fluorescent Antibody Technique, Indirect; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections, Intraperitoneal; Kainic Acid; Male; Motor Activity; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Substantia Nigra | 2008 |
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death.
Topics: Animals; Atorvastatin; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Ectodysplasins; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Kainic Acid; Male; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Tumor Necrosis Factor-alpha | 2008 |
Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brain.
Topics: Animals; Blotting, Western; Brain; Cell Line; Excitatory Amino Acid Agonists; Fibrinolysin; Humans; Kainic Acid; Learning; Memory; Mice; Mice, Knockout; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Seizures | 2008 |
Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures.
Topics: Acetylcholine; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cholinergic Agents; Convulsants; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Memory Disorders; Rats; Rats, Long-Evans; Ribosome Inactivating Proteins, Type 1; Risk Factors; Saporins; Seizures; Spatial Behavior | 2008 |
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.
Topics: Analysis of Variance; Animals; Biophysics; Cell Count; Electric Stimulation; gamma-Aminobutyric Acid; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neural Pathways; Neuronal Plasticity; Neuropilin-2; Patch-Clamp Techniques; Pentylenetetrazole; Receptors, GABA; Seizures; Silver Staining; Synapses | 2009 |
A single early-life seizure impairs short-term memory but does not alter spatial learning, recognition memory, or anxiety.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Conditioning, Classical; Disease Models, Animal; Exploratory Behavior; Fear; Female; Kainic Acid; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Pregnancy; Rats; Recognition, Psychology; Seizures; Space Perception | 2008 |
MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Stability; Excitatory Amino Acid Agonists; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kainic Acid; Membrane Potentials; Mice; Mice, Knockout; Neurons; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Potassium Chloride; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; RNA, Messenger; Seizures; Signal Transduction; Sulfonamides | 2008 |
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Death; Corticotropin-Releasing Hormone; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Indoles; Intermediate Filament Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurotoxicity Syndromes; Plant Lectins; Proteins; Reaction Time; RNA, Untranslated; Seizures | 2008 |
Calpain activity contributes to the control of SNAP-25 levels in neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cells, Cultured; Coumarins; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Protein Isoforms; Rats; Seizures; Synaptosomal-Associated Protein 25; Synaptosomes | 2008 |
Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamate Decarboxylase; Isoniazid; Kainic Acid; Male; Mice; Peptides, Cyclic; Reaction Time; Seizures; Stereotyped Behavior; Taurine | 2008 |
Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice.
Topics: Analysis of Variance; Animals; Enzyme Inhibitors; Fenclonine; Gene Expression Regulation; Hippocampus; Homeodomain Proteins; Kainic Acid; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Otx Transcription Factors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Serotonin; Serotonin Plasma Membrane Transport Proteins; Time Factors | 2008 |
Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats.
Topics: Aging; Animals; Cell Death; Estrogens; Female; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Ovariectomy; Progesterone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures | 2008 |
In vivo seizure induction and pharmacological preconditioning by domoic acid and isodomoic acids A, B and C.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Heptanoic Acids; Hippocampus; Isomerism; Kainic Acid; Male; Marine Toxins; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures | 2008 |
Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A(2A) receptors in rat hippocampus.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Ginsenosides; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Synaptosomes | 2009 |
Protection against kainate neurotoxicity by ginsenosides: attenuation of convulsive behavior, mitochondrial dysfunction, and oxidative stress.
Topics: Animals; Anticonvulsants; Antioxidants; Calcium; Ginsenosides; Glutathione; Hippocampus; Kainic Acid; Lipid Peroxidation; Male; Membrane Potential, Mitochondrial; Mitochondria; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase | 2009 |
Seizures increase importin-beta1 expression in NG2+ cells in the rat hippocampus.
Topics: Animals; Antigens; beta Karyopherins; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Hippocampus; Kainic Acid; Male; Neuroglia; Proteoglycans; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2009 |
NA+, K+-ATPase activity in the brain of the rats with kainic acid-induced seizures: influence of lamotrigine.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Lamotrigine; Rats; Rats, Wistar; Seizures; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Triazines | 2008 |
NMDA-induced seizure intensity is enhanced in COX-2 deficient mice.
Topics: Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fluoresceins; Gas Chromatography-Mass Spectrometry; Hexachlorocyclohexane; Insecticides; Kainic Acid; Male; Mice; Mice, Knockout; N-Methylaspartate; Organic Chemicals; Prostaglandins; Seizures | 2008 |
Dynamics of evoked local field potentials in the hippocampus of epileptic rats with spontaneous seizures.
Topics: Analysis of Variance; Animals; Biophysics; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Male; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2009 |
Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice.
Topics: Aging; Amino Acid Substitution; Animals; Brain; Cell Nucleus; Dementia; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Gene Dosage; Genetic Diseases, Inborn; Humans; Inclusion Bodies; Kainic Acid; Lysosomes; Mice; Mice, Transgenic; Mutation, Missense; Neurons; Neuropeptides; Neuroserpin; Seizures; Serpins; Spinal Cord | 2008 |
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous System Stimulants; Cerebrovascular Circulation; Convulsants; Electroshock; Hypnotics and Sedatives; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Picrotoxin; Rats; Rats, Wistar; Seizures; Sleep; Theophylline; Thyrotropin; Thyrotropin-Releasing Hormone | 2009 |
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.
Topics: Animals; Astrocytes; Ceramides; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Receptors, Interleukin-1; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Signal Transduction; Sphingomyelin Phosphodiesterase; src-Family Kinases | 2008 |
Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the rat.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Kainic Acid; Male; Rats; Rats, Long-Evans; Seizures; Transcranial Magnetic Stimulation | 2008 |
Prevention of epilepsy by taurine treatments in mice experimental model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Calpain; Cell Death; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy; Immunoblotting; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Neuroglia; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Seizures; Taurine | 2009 |
Temporal expression of AMP-activated protein kinase activation during the kainic acid-induced hippocampal cell death.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinase Kinases; Animals; Body Weight; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Caspase 3; Cell Death; Enzyme Activation; Excitatory Amino Acid Agonists; Glucose Transporter Type 1; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Protein Kinases; Seizures; Time Factors | 2009 |
Evaluation of carbamazepine pharmacokinetic profiles in mice with kainic acid-induced acute seizures.
Topics: Acute Disease; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Carbamazepine; Coloring Agents; Data Interpretation, Statistical; Drug Resistance; Excitatory Amino Acid Agonists; Infusions, Intravenous; Intestinal Mucosa; Kainic Acid; Male; Mice; Perfusion; Protein Binding; Reference Standards; Rhodamine 123; Seizures; Solutions | 2008 |
Cardiac sympathetic nerve activity during kainic acid-induced limbic cortical seizures in rats.
Topics: Animals; Blood Pressure; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Heart Rate; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Sympathetic Nervous System | 2009 |
The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 3; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neurotoxicity Syndromes; Phosphopyruvate Hydratase; Proto-Oncogene Proteins; Seizures; Stereotaxic Techniques; Time Factors | 2009 |
Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microglia; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Inbred F344; Seizures; Status Epilepticus; Thalamus | 2008 |
Nitric oxide regulates activity-dependent neuroprotective protein (ADNP) in the dentate gyrus of the rodent model of kainic acid-induced seizure.
Topics: Animals; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Homeodomain Proteins; Kainic Acid; Male; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Seizures; Soluble Guanylyl Cyclase | 2009 |
DDT exposure of zebrafish embryos enhances seizure susceptibility: relationship to fetal p,p'-DDE burden and domoic acid exposure of California sea lions.
Topics: Animals; Body Burden; California; DDT; Dichlorodiphenyl Dichloroethylene; Environmental Exposure; Fetus; Kainic Acid; Sea Lions; Seizures; Zebrafish | 2009 |
Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout mice.
Topics: Animals; Brain; Disease Susceptibility; Excitatory Amino Acid Agonists; Gene Expression Regulation; Homeodomain Proteins; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Parvalbumins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reaction Time; RNA, Messenger; Seizures; Somatostatin; Time Factors | 2009 |
Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis.
Topics: Adenosine; Adenosine Kinase; Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Green Fluorescent Proteins; Hippocampus; Humans; Indoles; Kainic Acid; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; MicroRNAs; Seizures; Tissue Engineering; Transfection | 2009 |
Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blotting, Western; Cell Death; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Wistar; Receptors, Kainic Acid; Resveratrol; Seizures; Stilbenes | 2009 |
Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Cell Death; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Hypoxia; Kainic Acid; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Time Factors | 2009 |
Development of spontaneous recurrent seizures after kainate-induced status epilepticus.
Topics: Action Potentials; Animals; Brain; Chronic Disease; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Signal Processing, Computer-Assisted; Status Epilepticus; Telemetry; Time Factors | 2009 |
Neuroprotection against excitotoxic brain injury in mice after ovarian steroid depletion.
Topics: Administration, Cutaneous; Animals; Brain; Carcinogens; Cell Death; Cyclohexenes; Disease Models, Animal; Estrogens; Excitatory Amino Acid Agonists; Female; Hippocampus; Histology; Injections, Intraperitoneal; Injections, Subcutaneous; Kainic Acid; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Ovarian Follicle; Ovariectomy; Ovary; Seizures; Vinyl Compounds | 2009 |
Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat: possible role of galanin.
Topics: Analysis of Variance; Animals; Autoradiography; Catheterization; Dose-Response Relationship, Drug; Galanin; Hippocampus; In Situ Hybridization; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Motor Activity; Peptide Fragments; Physical Conditioning, Animal; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2009 |
Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Bicuculline; Biophysics; Bumetanide; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agents; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Spectrum Analysis | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors | 2009 |
Effects of low dose neonatal domoic acid administration on behavioural and physiological response to mild stress in adult rats.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Corticosterone; Environment; Female; Immunohistochemistry; Kainic Acid; Male; Maze Learning; Neuromuscular Depolarizing Agents; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Seizures; Stress, Psychological; Swimming | 2009 |
Knockdown and overexpression of NR1 modulates NMDA receptor function.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bromodeoxyuridine; Cell Line, Transformed; Disease Models, Animal; Excitatory Amino Acid Agonists; Fear; Flow Cytometry; Gene Expression; Gene Expression Regulation; Gene Knockdown Techniques; Green Fluorescent Proteins; Hippocampus; Humans; Kainic Acid; Luminescent Proteins; Male; Memory; Microdissection; Neurogenesis; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Seizures; Transfection | 2009 |
Neuro-protective effects of carbamazepine on sleep patterns and head and body shakes in kainic acid-treated rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Calcium Channels, L-Type; Carbamazepine; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Serotonin; Sleep | 2009 |
Ketogenic diet attenuates kainic acid-induced hippocampal cell death by decreasing AMPK/ACC pathway activity and HSP70.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Apoptosis; Blotting, Western; Body Weight; Diet, Ketogenic; Gene Expression; Hippocampus; HSP70 Heat-Shock Proteins; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurotoxins; Phosphorylation; Seizures | 2009 |
Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.
Topics: Aging; Animals; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Cell Line; Cerebellum; Cerebral Cortex; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Oxidative Stress; Rats; Rats, Inbred F344; Seizures; Signal Transduction; Specific Pathogen-Free Organisms | 2009 |
Synchronized gamma oscillations (30-50 Hz) in the amygdalo-hippocampal network in relation with seizure propagation and severity.
Topics: Amygdala; Analysis of Variance; Animals; Cerebral Cortex; Hippocampus; Kainic Acid; Microelectrodes; Neural Pathways; Periodicity; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Time Factors | 2009 |
Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice.
Topics: Animals; Antigens; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Brain Injuries; Cell Nucleus; Cell Proliferation; Cytoplasm; Encephalitis; Female; Glial Fibrillary Acidic Protein; Kainic Acid; Lipopolysaccharides; Male; Mice; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Proteoglycans; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures; Stem Cells | 2009 |
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Fluoresceins; Gene Expression Regulation; Immunosuppressive Agents; In Situ Nick-End Labeling; Kainic Acid; Male; Mossy Fibers, Hippocampal; Organic Chemicals; Protein Kinases; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Video Recording | 2009 |
Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Organoselenium Compounds; Pentylenetetrazole; Pilocarpine; Quinoxalines; Rats; Rats, Wistar; Seizures; Time Factors; Treatment Outcome | 2009 |
Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats.
Topics: Animals; Blotting, Western; Electroencephalography; Electromyography; Electrophoretic Mobility Shift Assay; Indole Alkaloids; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; NF-kappa B; Oxindoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Seizures; Uncaria | 2009 |
Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blotting, Western; Cyclooxygenase 1; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Humans; Injections, Intraperitoneal; Kainic Acid; Mice; Mice, Transgenic; Presenilin-2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Receptors, Prostaglandin E; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2009 |
Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Astrocytes; Benzamides; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytoprotection; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Time Factors | 2009 |
Differential role of gonadal hormones on kainic acid-induced neurodegeneration in medial amygdaloid nucleus of female and male rats.
Topics: Amygdala; Androgens; Animals; Cell Survival; Estrogens; Female; Gonadal Hormones; Kainic Acid; Male; Nerve Degeneration; Neurons; Orchiectomy; Ovariectomy; Rats; Rats, Wistar; Seizures; Sex Factors; Testosterone | 2009 |
The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting.
Topics: Action Potentials; Adult Stem Cells; Analysis of Variance; Animals; Cell Count; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Combined Modality Therapy; Electroencephalography; Erythropoietin; Fluorescent Antibody Technique; Hippocampus; Infusion Pumps, Implantable; Interneurons; Kainic Acid; Male; Neural Inhibition; Neuronal Plasticity; Neurons; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted; Status Epilepticus; Stem Cell Transplantation | 2009 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin | 2010 |
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.
Topics: Adenosine Kinase; Animals; Astrocytes; Brain; Cell Death; Chronic Disease; Epilepsy; Gliosis; Kainic Acid; Male; Mice; Mice, Knockout; Mice, Transgenic; Pyramidal Cells; Recurrence; Seizures; Severity of Illness Index; Status Epilepticus; Time Factors; Tissue Distribution; Transgenes; Up-Regulation | 2008 |
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
Topics: Animals; Apoptosis; Baclofen; Disease Models, Animal; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Kainate Receptor; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; MAP Kinase Kinase Kinases; Membrane Proteins; Mitogen-Activated Protein Kinase 10; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Receptors, Kainic Acid; Seizures | 2010 |
Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats.
Topics: Animals; Apoptosis; Autoantibodies; CA1 Region, Hippocampal; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Erythropoietin; Hematopoiesis; Kainic Acid; Male; Neurons; Neuropeptide Y; Rats; Rats, Inbred F344; Receptors, Neuropeptide Y; Seizures; Severity of Illness Index; Signal Transduction; Up-Regulation | 2009 |
Spectral analysis of electrocorticographic activity during pharmacological preconditioning and seizure induction by intrahippocampal domoic acid.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electroencephalography; Hippocampus; Kainic Acid; Linear Models; Male; Rats; Rats, Sprague-Dawley; Seizures; Spectrum Analysis; Statistics, Nonparametric | 2010 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Lactic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Organ Size; Rats; Rats, Wistar; Seizures; Status Epilepticus; Time Factors | 2009 |
Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebral Hemorrhage; Excitatory Amino Acid Antagonists; Kainic Acid; Male; MicroRNAs; Rats; Rats, Sprague-Dawley; Seizures; Stroke; Up-Regulation | 2010 |
Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain.
Topics: Animals; Brain; Brain Injuries; Cell Count; Ibotenic Acid; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Neurons; Oligodendroglia; Rats; Rats, Wistar; Receptors, Calcium-Sensing; RNA, Messenger; Seizures; Time Factors | 2009 |
Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death.
Topics: Action Potentials; Analysis of Variance; Animals; Cell Count; Cell Death; Electrophysiology; Excitatory Amino Acid Agonists; Fluoresceins; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Membrane Potentials; Mice; Mice, Transgenic; Neurons; Organic Chemicals; Oscillometry; Periodicity; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Processing, Computer-Assisted; Staining and Labeling | 2009 |
Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Time Factors | 2010 |
Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Electrophysiology; Electroshock; Ganglia, Spinal; Kainic Acid; Male; Mice; Motor Activity; Neurons; Pentylenetetrazole; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Thyrotropin-Releasing Hormone | 2009 |
Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Glutamic Acid; Isoquinolines; Kainic Acid; Male; Mice; Mice, Transgenic; Models, Genetic; Neural Inhibition; Oncogene Proteins v-fos; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Seizures | 2010 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines | 2010 |
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 2009 |
Status epilepticus affects the gigantocellular network of the pontine reticular formation.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cell Shape; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Male; Muscarinic Agonists; Nerve Net; Neurons; Pilocarpine; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Reticular Formation; Seizures; Signal Processing, Computer-Assisted; Silver Staining; Status Epilepticus | 2009 |
Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo.
Topics: Animals; Blotting, Western; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cholesterol; Drug Carriers; Drug Compounding; Fatty Acids, Monounsaturated; Gene Silencing; Glutamic Acid; Humans; Immunohistochemistry; Kainic Acid; Liposomes; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Protein Transport; Proto-Oncogene Proteins c-jun; Quaternary Ammonium Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Seizures; Transferrin | 2010 |
Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice.
Topics: Amygdala; Animals; Cell Death; Cytoprotection; Electrodes, Implanted; Hippocampus; Kainic Acid; Mice; Microinjections; Neurons; Neuroprotective Agents; Sclerosis; Seizures; Status Epilepticus | 2010 |
A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Intercellular Signaling Peptides and Proteins; Kainic Acid; Male; Metallothionein; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Peptides; Rats; Rats, Wistar; Seizures | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.
Topics: Animals; Cerebral Cortex; Convulsants; Crosses, Genetic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Kainic Acid; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pentylenetetrazole; Reaction Time; Seizures; Selection, Genetic | 2010 |
Effects of early postnatal caffeine exposure on seizure susceptibility of rats are age- and model-dependent.
Topics: Age Factors; Analysis of Variance; Animals; Caffeine; Convulsants; Disease Susceptibility; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors | 2010 |
Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).
Topics: Animals; Blood-Brain Barrier; Capsid; Cell Line; Cell Survival; Dependovirus; Directed Molecular Evolution; DNA; Female; Genetic Therapy; Green Fluorescent Proteins; Humans; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Neurons; Rats; Seizures | 2010 |
Sanjoinine A isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions.
Topics: Administration, Oral; Alkaloids; Animals; Anticonvulsants; Apoptosis; Calcium; Cells, Cultured; Chlorides; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Seizures; Ziziphus | 2009 |
Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo.
Topics: Animals; Cortical Synchronization; Electroencephalography; Electrooculography; Epilepsy; Interneurons; Kainic Acid; Male; Nerve Net; Pilocarpine; Rats; Rats, Wistar; Seizures | 2010 |
Neuroprotective activity of Vitis thunbergii var. taiwaniana extracts in vitro and in vivo.
Topics: Animals; Antioxidants; Cell Death; Cell Line; Hippocampus; Hydrogen Peroxide; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Leaves; Plant Stems; Rats; Rats, Sprague-Dawley; Seizures; Vitis | 2010 |
Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; CA3 Region, Hippocampal; Disease Models, Animal; DNA; Kainic Acid; Male; Neurons; NF-kappa B; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Status Epilepticus; Time Factors; Transcription Factor RelA; Transcription, Genetic; Up-Regulation | 2010 |
Increased binding of inhibitory neuronal receptors in the hippocampus in kainate-treated rats with spontaneous limbic seizures.
Topics: Analysis of Variance; Animals; Autoradiography; Hippocampus; Kainic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, GABA-A; Seizures | 2010 |
Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus.
Topics: Actins; Animals; Dependovirus; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Hippocampus; Immunity, Humoral; Kainic Acid; Learning; Male; Memory; Motor Activity; Neuropeptide Y; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Seizures; Transduction, Genetic | 2010 |
An electron spin resonance study for real-time detection of ascorbyl free radicals after addition of dimethyl sulfoxide in murine hippocampus or plasma during kainic acid-induced seizures.
Topics: Animals; Ascorbic Acid; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Free Radicals; Hippocampus; Kainic Acid; Male; Mice; Seizures; Specimen Handling | 2010 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; HMGB1 Protein; Humans; Interleukin-1beta; Kainic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Toll-Like Receptor 4 | 2010 |
Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.
Topics: Animals; Apoptosis; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Ghrelin; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Microglia; Neurons; Seizures; Tumor Necrosis Factor-alpha | 2010 |
Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain.
Topics: Age Factors; Analysis of Variance; Animals; Brain; Cell Count; Cell Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Quinoxalines; Seizures; Severity of Illness Index; Species Specificity | 2010 |
Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice.
Topics: Animals; Animals, Newborn; Brain; Cell Count; Chi-Square Distribution; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Fluoresceins; Histamine H1 Antagonists; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Organic Chemicals; Receptors, Histamine H1; Seizures; Triprolidine | 2010 |
Zebrafish seizure model identifies p,p -DDE as the dominant contaminant of fetal California sea lions that accounts for synergistic activity with domoic acid.
Topics: Animals; Dichlorodiphenyl Dichloroethylene; Disease Models, Animal; Environmental Pollutants; Fetus; Halogenated Diphenyl Ethers; Hexachlorocyclohexane; Kainic Acid; Polychlorinated Biphenyls; Seizures; Zebrafish | 2010 |
Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice.
Topics: Aging; Animals; Brain; Excitatory Amino Acid Agonists; Female; Flow Cytometry; Immunohistochemistry; Interleukin-10; Interleukin-18; Interleukin-6; Kainic Acid; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Motor Activity; Neurodegenerative Diseases; Seizures; Tumor Necrosis Factor-alpha | 2010 |
Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.
Topics: Animals; Behavior, Animal; Blotting, Western; Female; Hippocampus; Hypothyroidism; Immunohistochemistry; Kainic Acid; Polymerase Chain Reaction; Rats; Receptors, Kainic Acid; Seizures | 2010 |
In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; GluK2 Kainate Receptor; Hippocampus; Isomerism; Kainic Acid; Male; Models, Molecular; Molecular Conformation; Neuromuscular Depolarizing Agents; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Synaptosomes; Tritium | 2010 |
Cholinergic regulation of striatal Nova mRNAs.
Topics: Animals; Antigens, Neoplasm; Corpus Striatum; Excitatory Amino Acid Agonists; Kainic Acid; Lithium Chloride; Male; Muscarinic Agonists; Muscarinic Antagonists; Nerve Tissue Proteins; Neuro-Oncological Ventral Antigen; Pilocarpine; Rats; Rats, Wistar; RNA-Binding Proteins; RNA, Messenger; Scopolamine; Seizures | 2010 |
Seizure tests distinguish intermittent fasting from the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Blood Glucose; Caloric Restriction; Diet, Ketogenic; Electroshock; Fasting; Kainic Acid; Male; Mice; Pentylenetetrazole; Seizures | 2010 |
Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Antimetabolites; Blood Glucose; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Kainic Acid; Kindling, Neurologic; Male; Mice; Movement Disorders; Pentylenetetrazole; Rats; Seizures; Time Factors | 2010 |
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure.
Topics: Aggrecans; Analysis of Variance; Animals; Cell Count; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Male; Parvalbumins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2010 |
The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Doublecortin Protein; Enzyme Inhibitors; Kainic Acid; Male; Neurogenesis; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Seizures; Stem Cells | 2010 |
Epileptic focus stimulation and seizure control in the rat model of kainic acid-induced limbic seizures.
Topics: Amygdala; Animals; Deep Brain Stimulation; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Linear Models; Male; Neural Pathways; Rats; Rats, Wistar; Seizures; Status Epilepticus; Stereotaxic Techniques; Thalamus | 2010 |
Efferent and afferent vagal actions on cortical blood flow and kainic acid-induced seizure activity in urethane anesthetized rats.
Topics: Animals; Blood Flow Velocity; Cerebral Cortex; Cerebrovascular Circulation; Kainic Acid; Male; Neurons, Afferent; Neurons, Efferent; Rats; Rats, Wistar; Seizures; Urethane; Vagus Nerve | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kainic Acid; Male; Mice; Motor Activity; Pentanones; Pentylenetetrazole; Seizures | 2010 |
Prolactin reduces the damaging effects of excitotoxicity in the dorsal hippocampus of the female rat independently of ovarian hormones.
Topics: Animals; Cell Count; Female; Gonadal Hormones; Hippocampus; Kainic Acid; Ovariectomy; Prolactin; Rats; Rats, Wistar; Seizures | 2010 |
BACE1 deficiency causes altered neuronal activity and neurodegeneration.
Topics: Action Potentials; Aging; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Axons; Brain; Cell Membrane; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Phenotype; Seizures; Sodium Channels | 2010 |
The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.
Topics: Adrenergic beta-3 Receptor Agonists; Animals; Anti-Inflammatory Agents; Apoptosis; Brain-Derived Neurotrophic Factor; Caspase 3; Clenbuterol; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Nerve Growth Factors; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2010 |
Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Homeodomain Proteins; Immunohistochemistry; Kainic Acid; Levetiracetam; Neurons; Nootropic Agents; Piracetam; Rats; Seizures; Status Epilepticus; Tetanus Toxin; Time Factors; Tumor Suppressor Proteins | 2010 |
YB-1 binds to GluR2 mRNA and CaM1 mRNA in the brain and regulates their translational levels in an activity-dependent manner.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Calmodulin; Carbachol; Cell Line; Cholinergic Agonists; Excitatory Amino Acid Agonists; Gene Expression Regulation; Kainic Acid; Mice; Nicotine; Nicotinic Agonists; Norepinephrine; Protein Isoforms; Rats; Receptors, AMPA; Recombinant Fusion Proteins; RNA, Messenger; RNA, Small Interfering; Seizures; Transcription Factors; Y-Box-Binding Protein 1 | 2010 |
Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Enzyme Activation; Excitatory Amino Acid Agonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Nerve Degeneration; Proto-Oncogene Proteins c-akt; Receptors, Dopamine D2; Seizures; Signal Transduction | 2010 |
Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis.
Topics: Animals; Blotting, Western; Brain; Cyclophilin A; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Epilepsy; Gene Expression; Kainic Acid; Macrophage Migration-Inhibitory Factors; Male; Phytotherapy; Plant Extracts; Proteomics; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Uncaria; Up-Regulation | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rotarod Performance Test; Seizures | 2010 |
Domoic acid induced seizures progress to a chronic state of epilepsy in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Epilepsy; Kainic Acid; Male; Marine Toxins; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures; Videotape Recording | 2011 |
Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electric Stimulation; Genetic Therapy; Genetic Vectors; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Protein Binding; Radiography; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neuropeptide Y; Seizures; Sulfur Isotopes; Transcription, Genetic | 2010 |
Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Disease Models, Animal; Estrous Cycle; Female; Incidence; Kainic Acid; Male; Methamphetamine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reaction Time; Seizures; Sex Factors | 2010 |
A hardware-algorithm co-design approach to optimize seizure detection algorithms for implantable applications.
Topics: Algorithms; Animals; Brain; Electroencephalography; Equipment Design; Female; Kainic Acid; Neural Prostheses; Rats; Rats, Long-Evans; Seizures; Signal Processing, Computer-Assisted | 2010 |
Congenic strains provide evidence that a mapped locus on chromosome 15 influences excitotoxic cell death.
Topics: Animals; Behavior, Animal; Cell Count; Cell Death; Chromosome Mapping; Chromosomes, Mammalian; DNA; Epilepsy, Temporal Lobe; Genotype; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Mice, Congenic; Mice, Inbred C57BL; Microsatellite Repeats; Neurons; Phenotype; Seizures | 2011 |
Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Animals; bcl-Associated Death Protein; Caspase 3; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Protein Kinase C-delta; Seizures; Serine | 2010 |
Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice.
Topics: Amygdala; Animals; CA3 Region, Hippocampal; Cell Count; Cell Death; Cytoprotection; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Neurons; Neuropeptide Y; Seizures; Status Epilepticus; Synapses; Time Factors | 2010 |
Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Neurons; Neurosurgical Procedures; Seizures | 2011 |
Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage.
Topics: Animals; Blood-Brain Barrier; Brain; Chemokine CCL3; Chemokine CCL5; Female; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Ligands; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, CCR5; Regeneration; RNA Interference; Seizures | 2011 |
Gene expression analysis of the emergence of epileptiform activity after focal injection of kainic acid into mouse hippocampus.
Topics: Animals; Cell Death; Gene Expression; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Neurons; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2010 |
Glutamatergic and morphological alterations associated with early life seizure-induced preconditioning in young rats.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; CA1 Region, Hippocampal; Calcium; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Kainic Acid; Neurons; Pregnancy; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Status Epilepticus | 2010 |
A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Hippocampus; Kainic Acid; Phenyl Ethers; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Seizures; Tissue Culture Techniques | 2011 |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
Topics: Aminopeptidases; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Lectins, C-Type; Male; Neurotoxins; Pancreatitis-Associated Proteins; Rats; Rats, Wistar; Seizures; Temporal Lobe | 2011 |
Proliferation changes in dentate gyrus of hippocampus during the first week following kainic acid-induced seizures.
Topics: Animals; Antibodies; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neuronal Plasticity; Neuropeptides; Seizures; Staining and Labeling; Time Factors | 2010 |
Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice.
Topics: Animals; Blotting, Southern; Blotting, Western; Cytoskeletal Proteins; DNA Primers; Gene Expression Profiling; Genotype; Immunohistochemistry; Kainic Acid; Luminescent Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuronal Plasticity; Seizures; Visual Cortex | 2011 |
[Effect of no mediator on kainic acid induced behavioral seizures in rats].
Topics: Animals; Arginine; Kainic Acid; Male; Nitric Oxide; Nitroarginine; Rats; Rats, Wistar; Seizures | 2003 |
Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.
Topics: Animals; CA1 Region, Hippocampal; Cation Transport Proteins; Cell Death; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Fluoresceins; Gene Expression Regulation, Viral; Green Fluorescent Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Organic Chemicals; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Seizures; Video Recording; Zinc | 2011 |
Myelin-associated glycoprotein protects neurons from excitotoxicity.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Vitro Techniques; Integrin beta Chains; Kainic Acid; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Proteins; Myelin-Associated Glycoprotein; N-Methylaspartate; Neurons; Peptide Fragments; Phosphoinositide Phospholipase C; Receptors, Cell Surface; Seizures; Signal Transduction; Tubulin | 2011 |
Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cell Death; Convulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diet; Dose-Response Relationship, Drug; Eating; Extinction, Psychological; Food-Drug Interactions; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Lactones; Male; Mice; Pentylenetetrazole; Seizures; Sulfones | 2011 |
Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats.
Topics: Animals; Benzothiadiazines; Convulsants; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Peripheral immune challenge with dsRNA enhances kainic acid-induced status epilepticus.
Topics: Animals; Brain; Disease Models, Animal; Female; Kainic Acid; Mice; Mice, Inbred C57BL; Poly I-C; RNA, Double-Stranded; Seizures; Status Epilepticus | 2011 |
Nucleoside triphosphate diphosphohydrolases role in the pathophysiology of cognitive impairment induced by seizure in early age.
Topics: Adenosine Triphosphate; Animals; Antigens, CD; Apyrase; Blotting, Western; Chromatography, High Pressure Liquid; Cognition Disorders; Convulsants; Gene Expression; Gene Expression Profiling; Hippocampus; Kainic Acid; Male; Maze Learning; Nucleoside-Triphosphatase; Pyrophosphatases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2011 |
Excitotoxicity by kainate-induced seizure causes diacylglycerol kinase ζ to shuttle from the nucleus to the cytoplasm in hippocampal neurons.
Topics: Animals; Apoptosis; Cell Nucleus; Convulsants; Cytoplasm; Diacylglycerol Kinase; Hippocampus; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; Neurons; Protein Transport; Rats; Rats, Wistar; Seizures | 2011 |
Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus.
Topics: Animals; Apoptosis; CA3 Region, Hippocampal; Electroencephalography; Kainic Acid; Mice; Mice, Knockout; Neurons; Neuropeptide Y; Phenotype; Seizures; Status Epilepticus; Tumor Suppressor Protein p53 | 2010 |
Kainate administered to adult zebrafish causes seizures similar to those in rodent models.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Quinoxalines; Rats; Receptors, Glutamate; Seizures; Zebrafish | 2011 |
Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CA1 Region, Hippocampal; Enkephalins; Guanidines; Humans; Interneurons; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Neurodegenerative Diseases; Protein Precursors; Pyramidal Cells; Receptors, Opioid, kappa; Seizures | 2011 |
Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Disease Susceptibility; Kainic Acid; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Seizures; Transcription Factor RelA | 2011 |
Sustained downregulation of YY1-associated protein-related protein gene expression in rat hippocampus induced by repeated electroconvulsive shock.
Topics: Age Factors; Animals; Blotting, Northern; Down-Regulation; Electroshock; Gene Expression; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Neurogenesis; Rats; Rats, Wistar; RNA, Messenger; Seizures; Transcription Factors | 2011 |
Prenatal corticosteroid exposure alters early developmental seizures and behavior.
Topics: Animals; Anxiety; Betamethasone; Canrenoic Acid; Convulsants; Disease Susceptibility; Exploratory Behavior; Female; Flurothyl; Hydrocortisone; Kainic Acid; Male; Maze Learning; Mineralocorticoid Receptor Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Seizures; Status Epilepticus; Weight Gain | 2011 |
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice.
Topics: 4-Aminobenzoic Acid; Animals; Anticonvulsants; Convulsants; Dipeptides; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred C57BL; para-Aminobenzoates; Seizures | 2011 |
Effect of stimulus parameters in the treatment of seizures by electrical stimulation in the kainate animal model.
Topics: Animals; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Kainic Acid; Models, Animal; Rats; Rats, Long-Evans; Seizures | 2011 |
Visualization of spatiotemporal energy dynamics of hippocampal neurons by mass spectrometry during a kainate-induced seizure.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Hippocampus; Kainic Acid; Mice; Neurons; Seizures; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Repeated citalopram administration counteracts kainic acid-induced spreading of PSA-NCAM-immunoreactive cells and loss of reelin in the adult mouse hippocampus.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Cell Count; Citalopram; Down-Regulation; Extracellular Matrix Proteins; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Neural Cell Adhesion Molecule L1; Neuronal Plasticity; Neurotoxins; Phenotype; Reelin Protein; RNA, Messenger; Seizures; Serine Endopeptidases; Sialic Acids | 2011 |
Isolated seizures in rats do not cause neuronal injury.
Topics: Animals; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Male; Neurons; Organ Size; Rats; Rats, Sprague-Dawley; Seizures | 2012 |
Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures.
Topics: Animals; Calbindin 2; Entorhinal Cortex; Hippocampus; Interneurons; Kainic Acid; Male; Nerve Fibers; Parvalbumins; Rats; RNA, Messenger; S100 Calcium Binding Protein G; Seizures; Thalamic Nuclei | 2011 |
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain.
Topics: Alternative Splicing; Animals; Apoptosis; Biomarkers; Blotting, Western; Brain; Cell Proliferation; Electrophysiology; Female; Gene Expression Profiling; Gene Expression Regulation; Immunoenzyme Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing Factors; RNA-Binding Proteins; RNA, Messenger; Seizures; Synaptic Transmission | 2011 |
Selective blockade of A(2A) receptor protects against neurotoxicity induced by kainic acid in young rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Catalase; Glutathione Peroxidase; Glutathione Transferase; Kainic Acid; Male; Neurotoxicity Syndromes; Oxidative Stress; Pyrimidines; Rats; Reactive Oxygen Species; Seizures; Triazoles | 2012 |
Ischemic cardiomyopathy following seizure induction by domoic Acid.
Topics: Animals; Behavior, Animal; Cardiomyopathies; Cytokines; Disease Models, Animal; Kainic Acid; Male; Mitochondria; Myocardial Ischemia; Neuromuscular Depolarizing Agents; Rats; Rats, Sprague-Dawley; Respiration; Seizures; Ventricular Dysfunction, Left | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Seizures; Spider Venoms; Synaptosomes; Tritium | 2011 |
Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dopamine; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Kainic Acid; Male; Oxcarbazepine; Rats; Rats, Wistar; Seizures; Serotonin; Sleep Stages | 2011 |
Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Fructose; Humans; Kainic Acid; Lipid Peroxidation; Male; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Seizures; Topiramate | 2011 |
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Topics: Animals; Antidepressive Agents; Biophysical Phenomena; Blood Glucose; Brain Infarction; CD8 Antigens; Cell Line, Transformed; Chlorocebus aethiops; Convulsants; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Eating; Electric Stimulation; Green Fluorescent Proteins; Hindlimb Suspension; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Potassium Channels; Potassium Channels, Tandem Pore Domain; Seizures; Swimming; Transfection | 2012 |
Protective effect of 2,2'-dithienyl diselenide on kainic acid-induced neurotoxicity in rat hippocampus.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Glutathione Peroxidase; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Reaction Time; Seizures; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Thiophenes; Thymidine; Trityl Compounds | 2011 |
Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Disease Susceptibility; Female; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures | 2011 |
Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Interleukin-1beta; Kainic Acid; Lactones; Mice; Mice, Knockout; Pentylenetetrazole; Receptors, Interleukin-1; Seizures; Sulfones | 2012 |
Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures.
Topics: Animals; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Neurons; Neuropeptide Y; Rats; Rats, Transgenic; Rats, Wistar; Receptors, Neuropeptide Y; Seizures | 2012 |
Brief seizures cause dendritic injury.
Topics: Animals; Cerebral Cortex; Dendrites; Dendritic Spines; Kainic Acid; Mice; Neurons; Seizures; Status Epilepticus; Time Factors | 2012 |
Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus.
Topics: Animals; Disease Models, Animal; Ghrelin; Kainic Acid; Male; Oligopeptides; Peptides; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2011 |
Targeting pannexin1 improves seizure outcome.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Behavior, Animal; Blotting, Western; Brain; Cells, Cultured; Connexins; Epilepsy; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Potassium; Seizures; Status Epilepticus | 2011 |
Hypothermia reduces brain edema, spontaneous recurrent seizure attack, and learning memory deficits in the kainic acid treated rats.
Topics: Animals; Brain Edema; Hypothermia, Induced; Kainic Acid; Learning; Memory Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Secondary Prevention; Seizures | 2011 |
Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Eicosanoids; Epilepsy, Temporal Lobe; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Plant Lectins; RNA, Messenger; Seizures; Signal Transduction; Time Factors | 2011 |
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Caspase 8; Cell Death; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Gene Deletion; Gliosis; Inflammation; Kainic Acid; Memory; Mice; Neurons; Neurotoxins; Seizures; Tumor Necrosis Factor-alpha | 2011 |
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
Topics: Adenosine; Adenosine Kinase; Amygdala; Animals; Disease Models, Animal; Electroencephalography; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Seizures; Time Factors | 2012 |
Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity.
Topics: Adiponectin; Adipose Tissue; Animals; Blood Glucose; Hippocampus; Kainic Acid; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; Seizures; Severity of Illness Index | 2011 |
Upregulation of arginine vasopressin synthesis in the rat hypothalamus after kainic acid-induced seizures.
Topics: Animals; Arginine Vasopressin; Convulsants; Gene Expression; Hypothalamus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Rats; Rats, Transgenic; Seizures; Up-Regulation | 2011 |
Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Kainic Acid; Male; Morpholines; Naphthalenes; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Seizures; Severity of Illness Index; Status Epilepticus | 2012 |
Induction of arginine vasopressin-enhanced green fluorescent protein expression in the locus coeruleus following kainic acid-induced seizures in rats.
Topics: Animals; Animals, Genetically Modified; Arginine Vasopressin; Dizocilpine Maleate; Female; Green Fluorescent Proteins; Kainic Acid; Locus Coeruleus; Male; Rats; Rats, Wistar; Recombinant Fusion Proteins; Seizures; Tyrosine 3-Monooxygenase; Up-Regulation | 2012 |
Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration.
Topics: Analysis of Variance; Animals; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Astrocytes; CD11b Antigen; Cytokines; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Exploratory Behavior; Flow Cytometry; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Seizures; Statistics, Nonparametric | 2012 |
Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.
Topics: Animals; Arachidonic Acids; Cannabinoids; Carrier Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; GTP-Binding Proteins; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Seizures | 2012 |
A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Food, Formulated; Kainic Acid; Male; Pharmaceutical Preparations; Rats; Seizures; Status Epilepticus; Time Factors; Treatment Outcome | 2012 |
Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation.
Topics: Animals; Brain; Gene Expression Profiling; Hippocampus; Kainic Acid; MicroRNAs; Post-Synaptic Density; Prosencephalon; Rats; Seizures; Synapses | 2012 |
Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Interleukin-1beta; Kainic Acid; Lorazepam; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neurons; Neuroprotective Agents; Purinergic P2X Receptor Agonists; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7; Seizures; Status Epilepticus | 2012 |
Stress and corticosteroid modulation of seizures and synaptic inhibition in the hippocampus.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biophysics; Disease Models, Animal; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Inhibition; Patch-Clamp Techniques; Rats; Rats, Wistar; Reaction Time; Seizures; Spironolactone; Stress, Psychological; Synapses; Time Factors | 2012 |
Epileptic seizure detection with the local field potential of anterior thalamic of rats aiming at real time application.
Topics: Algorithms; Animals; Deep Brain Stimulation; Disease Models, Animal; Electric Power Supplies; Electrodes; Electroencephalography; Epilepsy, Temporal Lobe; Equipment and Supplies; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures; Thalamus | 2011 |
Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cricetinae; Cricetulus; Disease Models, Animal; Electroencephalography; Fluoresceins; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Models, Biological; Nerve Tissue Proteins; Organic Chemicals; Phenylisopropyladenosine; Receptor, Adenosine A1; RGS Proteins; Seizures; Signal Transduction; Sulfonamides; Time Factors; Transfection; Xanthines | 2012 |
Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis.
Topics: Animals; Aquaporin 4; Astrocytes; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Neurons; Seizures; Status Epilepticus | 2012 |
Low-dose neonatal domoic acid causes persistent changes in behavioural and molecular indicators of stress response in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Female; Kainic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Corticotropin-Releasing Hormone; Receptors, Dopamine D2; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Steroid; Seizures; Sex Factors; Stress, Psychological | 2012 |
Synchrony dynamics across brain structures in limbic epilepsy vary between initiation and termination phases of seizures.
Topics: Animals; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Models, Neurological; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted | 2013 |
The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy.
Topics: Animals; Antidepressive Agents; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Kainic Acid; Male; Morpholines; Rats; Rats, Sprague-Dawley; Reboxetine; Seizures; Status Epilepticus; Time Factors; Treatment Outcome; Video Recording | 2012 |
MicroRNA-34a upregulation during seizure-induced neuronal death.
Topics: Animals; Apoptosis; Argonaute Proteins; Benzothiazoles; Hippocampus; Immunoprecipitation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Protein Binding; Seizures; Toluene; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish.
Topics: Aging; Animals; Docosahexaenoic Acids; Embryo, Nonmammalian; Female; Kainic Acid; Male; Seizures; Zebrafish | 2012 |
The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway.
Topics: Animals; Behavior, Animal; Blotting, Western; Epilepsy; Immunohistochemistry; Kainic Acid; Locomotion; Male; Rats; Seizures; TOR Serine-Threonine Kinases | 2012 |
Differential patterns of synaptotagmin7 mRNA expression in rats with kainate- and pilocarpine-induced seizures.
Topics: Animals; Kainic Acid; Male; Muscarinic Agonists; Muscarinic Antagonists; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger; Seizures; Synaptotagmins | 2012 |
Immunohistochemical demonstration of increased prostaglandin F₂α levels in the rat hippocampus following kainic acid-induced seizures.
Topics: Animals; CA3 Region, Hippocampal; Convulsants; Dinoprost; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Immunohistochemistry; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, Prostaglandin; Seizures; Staining and Labeling | 2012 |
Acute, but reversible, kainic acid-induced DNA damage in hippocampal CA1 pyramidal cells of p53-deficient mice.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cell Count; Cell Survival; DNA Breaks, Double-Stranded; DNA Damage; Excitatory Amino Acid Agonists; Female; Kainic Acid; Male; Mice; Mice, Knockout; Perfusion; Pregnancy; Pyramidal Cells; Seizures; Tumor Suppressor Protein p53 | 2012 |
Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures.
Topics: Animals; Apoptosis; Baclofen; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Caspase 3; Caspase Inhibitors; Convulsants; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Fas Ligand Protein; fas Receptor; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Kainic Acid; Male; Muscimol; Neuroprotective Agents; Neurotoxins; Nitrosation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, GABA; Seizures; Sulfhydryl Compounds; Thioredoxin-Disulfide Reductase | 2012 |
Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms.
Topics: A Kinase Anchor Proteins; Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dendrites; Dendritic Spines; Endosomes; Female; Gene Knockdown Techniques; Hippocampus; Kainic Acid; Lipoylation; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Neuronal Plasticity; Protein Transport; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, AMPA; Seizures | 2012 |
Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cells, Cultured; Choroid Plexus; Gene Expression; Hippocampus; Humans; Kainic Acid; L-Lactate Dehydrogenase; Male; Neurons; Primary Cell Culture; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agonists; Kainic Acid; Lithium; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2012 |
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.
Topics: Adult; Animals; CA3 Region, Hippocampal; Cell Death; Dendritic Spines; Epilepsy, Temporal Lobe; Gene Silencing; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Neurons; Neuroprotective Agents; Pyramidal Cells; Real-Time Polymerase Chain Reaction; Recurrence; Seizures; Status Epilepticus; Up-Regulation | 2012 |
Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures.
Topics: Action Potentials; Animals; Brain; Brain Mapping; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Magnetic Resonance Imaging; Male; Oxygen; Rats; Rats, Wistar; Seizures; Wakefulness | 2012 |
Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy.
Topics: Adult; Animals; Astrocytes; Case-Control Studies; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Immunoenzyme Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Middle Aged; Neurons; Sclerosis; Seizures; Signal Transduction; TOR Serine-Threonine Kinases; Young Adult | 2012 |
Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death.
Topics: Animals; Blotting, Western; Cell Death; Convulsants; Electroencephalography; Epilepsy; Gene Expression Profiling; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Up-Regulation | 2012 |
Protective effect of carbamazepine on kainic acid-induced neuronal cell death through activation of signal transducer and activator of transcription-3.
Topics: Animals; Apoptosis; CA3 Region, Hippocampal; Carbamazepine; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Phosphorylation; Seizures; STAT3 Transcription Factor; Transcription, Genetic; Up-Regulation | 2013 |
Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus.
Topics: Acupuncture Therapy; Animals; Apoptosis; Cytokines; Disease Models, Animal; Encephalitis; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Seizures | 2012 |
IL-1β induction and IL-6 suppression are associated with aggravated neuronal damage in a lipopolysaccharide-pretreated kainic acid-induced rat pup seizure model.
Topics: Animals; Animals, Newborn; Body Temperature; Brain Injuries; Cytokines; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hippocampus; Interleukin-1beta; Interleukin-6; Kainic Acid; Lipopolysaccharides; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Statistics, Nonparametric; Status Epilepticus; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
The Rho-kinase (ROCK) inhibitor Y-27632 protects against excitotoxicity-induced neuronal death in vivo and in vitro.
Topics: Amides; Animals; Anticonvulsants; Astrocytes; Cell Death; Cells, Cultured; Convulsants; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Myosin Light Chains; Nerve Tissue Proteins; Neurites; Neurons; Neurotoxins; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Seizures; Single-Blind Method | 2013 |
The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats.
Topics: Animals; Caspase 3; Gene Expression Regulation; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kainic Acid; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Seizures; Simvastatin; Status Epilepticus | 2012 |
Neurogenesis response of middle-aged hippocampus to acute seizure activity.
Topics: Age Factors; Animals; Bromodeoxyuridine; Doublecortin Protein; Hippocampus; Kainic Acid; Neurogenesis; Rats; Rats, Sprague-Dawley; Seizures | 2012 |
Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.
Topics: Animals; Cholesterol; Hippocampus; Kainic Acid; Lovastatin; Mice; Neurons; Seizures; Status Epilepticus | 2012 |
N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
Topics: Animals; Arginine; Brain Waves; Dentate Gyrus; Diazepam; Disease Models, Animal; Gliosis; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fos; Seizures; Status Epilepticus; Synapses; Synaptophysin; Telemetry | 2012 |
Protection of apigenin against kainate-induced excitotoxicity by anti-oxidative effects.
Topics: Animals; Antioxidants; Apigenin; Carduus; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Glutathione; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Seizures | 2012 |
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Cyclosporine; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Recurrence; Seizures | 2012 |
The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Topics: 3-Hydroxybutyric Acid; Acute Disease; Animals; Anticonvulsants; Blood Glucose; Blotting, Western; Cerebral Cortex; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Immunosuppressive Agents; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Pentylenetetrazole; Phosphorylation; Ribosomal Protein S6; Seizures; Sirolimus; Time Factors; TOR Serine-Threonine Kinases | 2012 |
The synergic effect of regular exercise and resveratrol on kainate-induced oxidative stress and seizure activity in mice.
Topics: Anaerobic Threshold; Animals; Antioxidants; Body Weight; Catalase; Kainic Acid; Lactic Acid; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Physical Conditioning, Animal; Resveratrol; Seizures; Stilbenes; Superoxide Dismutase; Swimming | 2013 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; Ethosuximide; Hyperkinesis; Kainic Acid; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nimodipine; Seizures; Synaptosomal-Associated Protein 25; Valproic Acid | 2014 |
Effect of different mild hypoxia manipulations on kainic acid-induced seizures in the hippocampus of rats.
Topics: Animals; Apoptosis; Behavior, Animal; Blotting, Western; Cognition; DNA Fragmentation; Excitatory Amino Acid Agonists; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Ischemic Postconditioning; Ischemic Preconditioning; Kainic Acid; Male; Maze Learning; Microinjections; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques; Up-Regulation | 2013 |
Antiepileptic effects of levetiracetam in a rodent neonatal seizure model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Blotting, Western; Brain; Immunohistochemistry; Kainic Acid; Levetiracetam; Membrane Glycoproteins; Nerve Tissue Proteins; Piracetam; Rats; Seizures | 2013 |
The metastasis-promoting S100A4 protein confers neuroprotection in brain injury.
Topics: Amino Acid Motifs; Animals; Brain Injuries; Cell Death; Cytoprotection; Female; Gene Deletion; HEK293 Cells; Humans; Janus Kinases; Kainic Acid; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Peptides; Rats; Receptors, Interleukin-10; S100 Calcium-Binding Protein A4; S100 Proteins; Seizures; STAT Transcription Factors; Up-Regulation | 2012 |
Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; beta Catenin; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dishevelled Proteins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Dopamine D2; Seizures; Serine; Transcription, Genetic; Wnt Signaling Pathway | 2013 |
Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
Topics: Amino Acids; Animals; Anxiety; Behavior, Animal; Benzylamines; Excitatory Amino Acid Antagonists; Female; GABA-A Receptor Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Munc18 Proteins; Phosphinic Acids; Pregnancy; Prenatal Exposure Delayed Effects; R-SNARE Proteins; rab3A GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Seizures; Stress, Psychological; Synapsins; Synaptic Transmission; Synaptophysin; Syntaxin 1; Xanthenes | 2012 |
Manganese-enhanced MRI reflects seizure outcome in a model for mesial temporal lobe epilepsy.
Topics: Animals; Contrast Media; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Image Interpretation, Computer-Assisted; Kainic Acid; Magnetic Resonance Imaging; Male; Manganese; Rats; Rats, Wistar; Seizures | 2013 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks Large Homolog 4 Protein; Excitatory Postsynaptic Potentials; Gene Knock-In Techniques; Guanylate Kinases; Hippocampus; Humans; Hypoxia; Kainic Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Phosphorylation; Receptors, AMPA; Seizures; Serine | 2012 |
Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Waves; Disease Models, Animal; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Hippocampus; Kainic Acid; Methyl-CpG-Binding Protein 2; Mice; Nerve Net; Neurons; Potassium Channel Blockers; Rett Syndrome; Seizures | 2013 |
Kainic acid-induced seizure activity alters the mRNA expression and G-protein activation of the opioid/nociceptin receptors in the rat brain cortex.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation; GTP-Binding Proteins; Kainic Acid; Male; Nociceptin Receptor; Opioid Peptides; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Seizures | 2013 |
Neonatal immune challenge exacerbates seizure-induced hippocampus-dependent memory impairment in adult rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Cytokines; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Maze Learning; Memory Disorders; Minocycline; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors; Up-Regulation | 2013 |
Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy.
Topics: Animals; Aquaporin 4; Astrocytes; Cell Polarity; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2013 |
Involvement of the neuropeptide orphanin FQ/nociceptin in kainate and kindling seizures and epileptogenesis.
Topics: Animals; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Nociceptin; Nociceptin Receptor; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Seizures | 2002 |
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Topics: Amygdala; Animals; Apoptosis; Caspase 6; Caspase 7; Caspases; Convulsants; Diazepam; Electroencephalography; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; GABA Agonists; Glioma; HeLa Cells; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Jurkat Cells; Kainic Acid; Lamin Type A; Lamins; Male; Microinjections; Nerve Tissue Proteins; Nuclear Proteins; Rats; Rats, Sprague-Dawley; Seizures; Staurosporine; Tumor Cells, Cultured | 2002 |
Osteopontin in kainic acid-induced microglial reactions in the rat brain.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Brain; In Situ Hybridization; Kainic Acid; Kinetics; Male; Membrane Glycoproteins; Microglia; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sialoglycoproteins; Tissue Distribution | 2002 |
Pharmacology of celecoxib in rat brain after kainate administration.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Brain; Brain Chemistry; Celecoxib; Cyclooxygenase Inhibitors; Dexamethasone; DNA Primers; Excitatory Amino Acid Agonists; Kainic Acid; Male; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Spinal Cord; Sulfonamides | 2002 |
Nitric oxide synthase inhibition suppresses wet dog shakes and augments convulsions in rats.
Topics: Animals; Brain; Dogs; Excitatory Amino Acid Agonists; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Seizures; Water | 2002 |
Perirhinal cortical lesion suppresses the secondary generalization in kainic acid-induced limbic seizure.
Topics: Animals; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Limbic System; Male; Motor Activity; Rats; Rats, Wistar; Seizures | 2002 |
Activity-dependent regulation of genes implicated in X-linked non-specific mental retardation.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Connexins; Excitatory Amino Acid Agonists; Eye Proteins; Gap Junction delta-2 Protein; Gene Expression Regulation; Genetic Linkage; Hippocampus; Intellectual Disability; Interleukin-1 Receptor Accessory Protein; Kainic Acid; Long-Term Potentiation; Mice; Organ Culture Techniques; p21-Activated Kinases; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Serine-Threonine Kinases; Receptors, Interleukin-1; RNA, Messenger; Seizures; Small-Conductance Calcium-Activated Potassium Channels; Up-Regulation; X Chromosome | 2002 |
Proconvulsant-induced seizures in alpha(4) nicotinic acetylcholine receptor subunit knockout mice.
Topics: 4-Aminopyridine; Animals; Bicuculline; Binding, Competitive; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; GABA Antagonists; Genotype; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Potassium Channel Blockers; Receptors, GABA-A; Receptors, Nicotinic; Seizures; Strychnine | 2002 |
Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cerebellum; Dioxoles; Excitatory Amino Acid Antagonists; Isoxazoles; Kainic Acid; Male; Mice; Mice, Inbred DBA; Models, Molecular; Motor Activity; Neurons; Patch-Clamp Techniques; Phenylacetates; Propionates; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Semicarbazones; Structure-Activity Relationship | 2002 |
Seizure induced dentate neurogenesis does not diminish with age in rats.
Topics: Aging; Animals; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures | 2002 |
Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Active Transport, Cell Nucleus; Amygdala; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Cell Death; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Microinjections; Mitochondria; Neurons; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Tyrosine 3-Monooxygenase | 2002 |
Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Astrocytes; Brain; Cell Communication; Connexins; Excitatory Amino Acid Agonists; Gene Expression; Immunohistochemistry; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; RNA, Messenger; Seizures; Status Epilepticus; Up-Regulation | 2002 |
C-fos-deficient mouse hippocampal CA3 pyramidal neurons exhibit both enhanced basal and kainic acid-induced excitability.
Topics: Animals; Electroencephalography; Evoked Potentials; Excitatory Amino Acid Agonists; Genes, fos; Kainic Acid; Male; Mice; Mice, Neurologic Mutants; Organ Culture Techniques; Pyramidal Cells; Seizures | 2002 |
Kainic acid induces leukemia inhibitory factor mRNA expression in the rat brain: differences in the time course of mRNA expression between the dentate gyrus and hippocampal CA1/CA3 subfields.
Topics: Animals; Cell Differentiation; Cell Division; Cell Movement; Dentate Gyrus; Excitatory Amino Acid Agonists; Gene Expression Regulation; Growth Inhibitors; Hippocampus; Interleukin-6; Kainic Acid; Leukemia Inhibitory Factor; Lymphokines; Male; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors; Up-Regulation | 2002 |
Differential changes of calcium binding proteins in the rat striatum after kainic acid-induced seizure.
Topics: Animals; Calbindin 1; Calbindin 2; Calbindins; Calcium-Binding Proteins; Corpus Striatum; Densitometry; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Neurons; Parvalbumins; Rats; Rats, Inbred F344; S100 Calcium Binding Protein G; Seizures | 2002 |
AIDA, a class I metabotropic glutamate-receptor antagonist limits kainate-induced hippocampal dysfunction.
Topics: Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; Indans; Kainic Acid; Male; Maze Learning; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Severity of Illness Index; Swimming | 2002 |
The effect of octreotide on kainate-induced wet dog shakes and seizure activity in male and female rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Female; Hormones; Kainic Acid; Male; Octreotide; Rats; Rats, Sprague-Dawley; Seizures; Sex Factors; Time Factors | 2002 |
Neuropilin-2 is overexpressed in the rat brain after limbic seizures.
Topics: Actins; Animals; Blotting, Northern; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Neuronal Plasticity; Neuropilin-2; Prosencephalon; Rats; Rats, Wistar; RNA, Messenger; Seizures; Time Factors | 2002 |
Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures.
Topics: Animals; Benzimidazoles; Binding, Competitive; Brain; Cell Membrane; Disease Models, Animal; Hippocampus; Homozygote; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Organ Specificity; Piperidines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Seizures; Thalamus | 2002 |
L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat.
Topics: Animals; Brain; Excitatory Amino Acid Antagonists; Kainic Acid; Kynurenine; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Seizures | 2002 |
Effect of kainic acid-induced seizures on sleep patterns.
Topics: Animals; Arousal; Behavior, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Limbic System; Male; Motor Activity; Polysomnography; Rats; Rats, Wistar; Seizures; Sleep; Sleep, REM | 2002 |
Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist.
Topics: Animals; Anticonvulsants; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Histological Techniques; Indans; Kainic Acid; Lamotrigine; Male; Mice; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Seizures; Triazines | 2002 |
Glial-neuronal interactions following kainate injection in rats.
Topics: Acetates; Acetyl Coenzyme A; Amino Acids; Animals; Astrocytes; Carbon Isotopes; Chromatography, High Pressure Liquid; Citric Acid Cycle; Convulsants; Glucose; Kainic Acid; Limbic System; Male; Neuroglia; Neurons; Nuclear Magnetic Resonance, Biomolecular; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley; Seizures | 2003 |
Structural and functional asymmetry in the normal and epileptic rat dentate gyrus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Electrophysiology; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Neuropeptide Y; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Synapses | 2002 |
Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Receptors, AMPA; RNA, Messenger; Seizures; Synapses | 2002 |
GnRH-immunoreactive fiber changes with unilateral amygdala-kindled seizures.
Topics: Amygdala; Animals; Disease Models, Animal; Female; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2002 |
Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice.
Topics: Animals; Anticonvulsants; Dextromethorphan; Dextrorphan; DNA; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred DBA; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Opioid, delta; Seizures; Transcription Factor AP-1 | 2003 |
Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Size; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neuroglia; Neuroprotective Agents; Rats; Rats, Inbred F344; Seizures; Transforming Growth Factor beta; Transforming Growth Factor beta3 | 2002 |
Seizure-mediated neuronal activation induces DREAM gene expression in the mouse brain.
Topics: Animals; Calcium-Binding Proteins; Convulsants; Cycloheximide; Dizocilpine Maleate; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Kv Channel-Interacting Proteins; Male; Mice; Neurons; Neuroprotective Agents; Pentylenetetrazole; Protein Synthesis Inhibitors; Repressor Proteins; RNA, Messenger; Seizures; Time Factors | 2002 |
Differential effects of dihydropyridine calcium channel blockers in kainic acid-induced experimental seizures in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Rats; Rats, Wistar; Seizures | 2003 |
Zinc chelation during non-lesioning overexcitation results in neuronal death in the mouse hippocampus.
Topics: Animals; Cell Death; Chelating Agents; Ditiocarb; Hippocampus; Kainic Acid; Male; Mice; Neurons; Seizures; Zinc | 2003 |
The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice.
Topics: Animals; Behavior, Animal; Caspase 3; Caspases; Cell Death; Diet; Fatty Acids, Unsaturated; Health; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Ketone Bodies; Male; Mice; Mice, Inbred ICR; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Weight Gain | 2003 |
Abnormal kainic acid receptor density and reduced seizure susceptibility in dystrophin-deficient mdx mice.
Topics: Animals; Dystrophin; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Receptors, Kainic Acid; Seizures | 2003 |
Increased mu-opioid receptor labeling is found on inner molecular layer terminals of the dentate gyrus following seizures.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Enkephalins; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Seizures | 2003 |
Blood genomic expression profile for neuronal injury.
Topics: Animals; Blood Physiological Phenomena; Brain Diseases; Down-Regulation; Gene Expression Profiling; Genome; Ischemic Attack, Transient; Kainic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Monocytes; Neuropeptides; Oligonucleotide Array Sequence Analysis; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death.
Topics: Animals; Behavior, Animal; Caspase 3; Caspases; Cell Death; Enzyme Activation; Heat-Shock Proteins; Hippocampus; In Situ Hybridization; Kainic Acid; Mice; Mice, Transgenic; Molecular Chaperones; Neoplasm Proteins; Neuroprotective Agents; Seizures | 2003 |
Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Extracellular Space; Female; Glucose; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Lactic Acid; Microdialysis; Phosphocreatine; Rats; Seizures; Telencephalon; Time Factors | 2002 |
Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients.
Topics: Animals; Brain; Calcium-Binding Proteins; Down-Regulation; Epilepsy; Gene Expression Regulation; Humans; Kainic Acid; Kv Channel-Interacting Proteins; Male; Mice; Mice, Inbred C57BL; Patients; Repressor Proteins; Seizures | 2003 |
Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.
Topics: Animals; Behavior, Animal; Cues; Excitatory Amino Acid Agonists; GABA Modulators; Kainic Acid; Learning; Male; Maze Learning; Memory; Phenobarbital; Rats; Rats, Long-Evans; Seizures | 2000 |
Age dependence of seizure-induced oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitate Hydratase; Aging; Animals; Cerebral Cortex; Deoxyguanosine; DNA Damage; Excitatory Amino Acid Agonists; Fumarate Hydratase; Hippocampus; Immunoblotting; Kainic Acid; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase; Superoxides | 2003 |
Convulsive and postural effects of lesioning the mid-substantia nigra pars reticulata in naïve and 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cortical Synchronization; Disease Models, Animal; Dopamine Agonists; Female; Functional Laterality; Kainic Acid; Motor Activity; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Posture; Rats; Rats, Sprague-Dawley; Rotation; Seizures; Substantia Nigra | 2003 |
Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Modulators; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; GABA Antagonists; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Limbic System; Mice; Mice, Knockout; Neurons; Neurotoxins; Polyunsaturated Alkamides; Seizures | 2003 |
Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Kainic Acid; Ketoglutaric Acids; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Oxaloacetic Acid; Seizures | 2003 |
Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Agonists; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Ketanserin; Male; Methiothepin; Rats; Rats, Wistar; Seizures; Serotonin; Serotonin Antagonists | 2003 |
The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals.
Topics: Animals; Ataxia; Behavior, Animal; Catalepsy; Diamines; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Memantine; Mice; Mice, Inbred Strains; N-Methylaspartate; Quaternary Ammonium Compounds; Seizures; Structure-Activity Relationship; Time Factors | 2003 |
Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Carrier Proteins; Cell Death; Hippocampus; Immunohistochemistry; Ion Channels; Kainic Acid; Limbic System; Membrane Proteins; Membrane Transport Proteins; Mitochondrial Proteins; Neurons; Neurotoxins; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Uncoupling Protein 1; Uncoupling Protein 2 | 2003 |
Susceptibility to kainate-induced seizures under dietary zinc deficiency.
Topics: Animals; Brain; Brain Chemistry; Deficiency Diseases; Disease Susceptibility; Dose-Response Relationship, Drug; Extracellular Space; Food, Formulated; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strains; Microdialysis; Neurotransmitter Agents; Rats; Rats, Wistar; Seizures; Synaptic Vesicles; Zinc | 2003 |
In vivo modulation of hippocampal epileptiform activity with radial electric fields.
Topics: Amplifiers, Electronic; Animals; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; Electrodes, Implanted; Electronics, Medical; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; Membrane Potentials; Microelectrodes; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques | 2003 |
Increased hippocampal CA3 vulnerability to low-level kainic acid following lateral fluid percussion injury.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Cell Count; Excitatory Amino Acid Agonists; Functional Laterality; Glucose; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2003 |
Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment.
Topics: Animals; Biomarkers; Cell Count; Cell Death; Disease Models, Animal; Drug Implants; Estradiol; Female; Hippocampus; Kainic Acid; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Survival Rate | 2003 |
Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6.
Topics: Animals; Astrocytes; Brain; Cholinergic Agonists; Excitatory Amino Acid Agents; Glial Fibrillary Acidic Protein; Interleukin-6; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Seizures; Tumor Necrosis Factor-alpha | 2003 |
Zinc movement in the brain under kainate-induced seizures.
Topics: Animals; Brain; Kainic Acid; Male; Mice; Movement; Rats; Rats, Wistar; Seizures; Zinc | 2003 |
Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion.
Topics: Animals; Cell Death; Dependovirus; Electroencephalography; Excitatory Amino Acid Agonists; Galanin; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Hippocampus; Humans; Kainic Acid; Luminescent Proteins; Male; Microinjections; Neurons; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Seizures | 2003 |
Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures.
Topics: Adult; Animals; Antibody Specificity; Blotting, Northern; Cells, Cultured; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Kainic Acid; Limbic System; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Neurons; Phosphate Transport Proteins; Rats; RNA, Messenger; Seizures | 2003 |
Interaction of 14-3-3 with Bid during seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Amygdala; Animals; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Casein Kinases; Cytochrome c Group; Disease Models, Animal; Hippocampus; Kainic Acid; Male; Mitochondria; Neurons; Protein Binding; Protein Kinases; Rats; Seizures; Tyrosine 3-Monooxygenase | 2003 |
Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Chelating Agents; Edetic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Seizures; Zinc | 2003 |
Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Amygdala; Animals; Antigens, CD; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Count; Cerebral Cortex; Death-Associated Protein Kinases; Disease Models, Animal; Electroencephalography; Enzyme Activation; Fas-Associated Death Domain Protein; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Seizures; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2003 |
Diffusion-weighted imaging in kainic acid-induced complex partial status epilepticus in dogs.
Topics: Algorithms; Animals; Dogs; Excitatory Amino Acid Agonists; Image Processing, Computer-Assisted; Kainic Acid; Seizures; Status Epilepticus; Stereotaxic Techniques; Time Factors | 2003 |
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection.
Topics: Administration, Intranasal; Amino Acid Sequence; Animals; Apoptosis; Behavior, Animal; Cognition; Gene Expression; Gene Transfer Techniques; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hippocampus; Kainic Acid; Learning; Male; Mice; Mice, Knockout; Molecular Sequence Data; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Seizures; Sequence Homology, Amino Acid; Signal Transduction | 2003 |
7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure.
Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Indazoles; Kainic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Rats; Rats, Wistar; Seizures; Time Factors | 2003 |
Genetic basis of kainate-induced excitotoxicity in mice: phenotypic modulation of seizure-induced cell death.
Topics: Animals; Cell Count; Cell Death; Chimera; Excitatory Amino Acid Agonists; Female; Fluoresceins; Fluorescent Dyes; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurons; Organic Chemicals; Phenotype; Seizures; Species Specificity; Staining and Labeling; Time Factors | 2003 |
Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Blood Vessels; Cell Count; Cell Death; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; GABA Modulators; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Membrane Glycoproteins; Neuroglia; Neurons; Organ Culture Techniques; Phenanthrolines; Phenylmercury Compounds; Protease Inhibitors; Rats; Rats, Wistar; Seizures; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2003 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures | 2003 |
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
Topics: Animals; Apoptosis; Brain Infarction; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; HSP70 Heat-Shock Proteins; Ischemic Attack, Transient; Kainic Acid; Male; Mice; Mice, Transgenic; Neurons; Rats; Seizures | 2003 |
Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology.
Topics: Animals; Cell Death; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Seizures; Species Specificity | 2003 |
Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Autoradiography; Brain; Connexins; Densitometry; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Time Factors; Tubulin | 2003 |
Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development.
Topics: Animals; Cell Line; Dependovirus; Electroencephalography; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Functional Laterality; Galanin; Genetic Therapy; Genetic Vectors; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Kidney; Male; Organic Chemicals; Rats; Seizures; Time Factors; Transfection | 2003 |
Androgens modulate neuronal vulnerability to kainate lesion.
Topics: Androgens; Animals; Behavior, Animal; Cell Count; Cell Survival; Dihydrotestosterone; Drug Interactions; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Orchiectomy; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Androgen; Seizures; Septum of Brain | 2003 |
[Responses of neurons and astrocytes in rat hippocampus to kainic acid-induced seizures].
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures | 2003 |
Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Behavior, Animal; Chondroitin Sulfate Proteoglycans; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Immunoblotting; Immunoglobulin G; Kainic Acid; Lectins, C-Type; Limbic System; Male; Microscopy, Confocal; Microscopy, Fluorescence; Nerve Degeneration; Nerve Net; Nerve Tissue Proteins; Neurocan; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Seizures | 2003 |
Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury.
Topics: Animals; Cell Count; Cell Death; Chelating Agents; Edetic Acid; Excitatory Amino Acid Agonists; Genotype; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Kainic Acid; Male; Metallothionein 3; Mice; Mice, Knockout; Nerve Tissue Proteins; Nitric Oxide Donors; Nitroprusside; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Thalamus; Zinc | 2003 |
Adult-born hippocampal neurons mature into activity-dependent responsiveness.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cellular Senescence; Female; Gene Expression; Genes, Immediate-Early; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Pentylenetetrazole; Phosphopyruvate Hydratase; Seizures | 2003 |
Seizures preferentially stimulate proliferation of radial glia-like astrocytes in the adult dentate gyrus: functional and immunocytochemical analysis.
Topics: Animals; Animals, Newborn; Astrocytes; Bromodeoxyuridine; Cell Count; Cell Differentiation; Dentate Gyrus; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Luminescent Proteins; Membrane Potentials; Mice; Mice, Transgenic; Microscopy, Confocal; Nerve Tissue Proteins; Neural Cell Adhesion Molecule L1; Neurons; Patch-Clamp Techniques; Phenotype; S100 Proteins; Seizures; Sialic Acids | 2003 |
The dual response of protein kinase Fyn to neural trauma: early induction in neurons and delayed induction in reactive astrocytes.
Topics: Animals; Astrocytes; Blotting, Western; Brain Damage, Chronic; Cell Death; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Enzyme Induction; Kainic Acid; Male; Mice; Neurons; Organ Specificity; Perforant Pathway; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; RNA Probes; RNA, Messenger; Seizures | 2004 |
Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Female; Gene Expression Regulation; Hippocampus; Kainic Acid; Limbic System; Neurons; Rats; Rats, Wistar; Seizures | 2004 |
Translamellar disinhibition in the rat hippocampal dentate gyrus after seizure-induced degeneration of vulnerable hilar neurons.
Topics: Animals; Axonal Transport; Cell Survival; Dentate Gyrus; Diffusion; Electric Stimulation; Fluorescent Dyes; GABA Antagonists; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neural Inhibition; Neurons; Perforant Pathway; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Stilbamidines | 2004 |
A role of glial fibrillary acidic protein in hippocampal degeneration after cerebral trauma or kainate-induced seizure.
Topics: Animals; Brain Injuries; Cell Survival; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Seizures; Wounds, Nonpenetrating | 2003 |
Characteristic phosphorylation of the extracellular signal-regulated kinase pathway after kainate-induced seizures in the rat hippocampus.
Topics: Animals; Astrocytes; Blotting, Western; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Seizures; Staining and Labeling | 2003 |
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis.
Topics: Animals; B-Lymphocyte Subsets; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Neurotoxins; Seizures; T-Lymphocyte Subsets | 2004 |
Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Boron Compounds; Calpain; Caspase 3; Caspases; Deoxyribonucleases; Disease Models, Animal; DNA Fragmentation; Kainic Acid; Male; Necrosis; Nerve Degeneration; Proteins; Rats; Rats, Sprague-Dawley; Seizures; Spectrin; Status Epilepticus; Time | 2004 |
Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.
Topics: Aconitate Hydratase; Amino Acid Transport System X-AG; Animals; Deoxyadenosines; Epilepsy; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Mice; Mice, Knockout; Mitochondria; Neurodegenerative Diseases; Neurotoxins; Oxidative Stress; Oxygen; Seizures; Superoxide Dismutase; Superoxides | 2004 |
The three sorCS genes are differentially expressed and regulated by synaptic activity.
Topics: Animals; Animals, Newborn; Brain; DNA, Complementary; Gene Expression Regulation, Developmental; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Protein Synthesis Inhibitors; Receptors, Cell Surface; Seizures; Synaptic Transmission | 2004 |
Hypothermia during kainic acid-induced seizures reduces hippocampal lesions and cerebral nitric oxide production in immature rabbits.
Topics: Animals; Blood Pressure; Brain Chemistry; Cerebrovascular Circulation; Electroencephalography; Excitatory Amino Acid Agonists; Female; Hippocampus; Hypothermia, Induced; Kainic Acid; Nitric Oxide; Pyramidal Cells; Rabbits; Seizures | 2004 |
Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat.
Topics: 14-3-3 Proteins; Animals; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carrier Proteins; Caspase 8; Caspases; Cell Death; Cytoplasm; Functional Laterality; Hippocampus; Kainic Acid; Male; Microsomes; Mitochondria; Neurons; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Seizures; Subcellular Fractions; Tyrosine 3-Monooxygenase | 2004 |
Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.
Topics: Animals; Dependovirus; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome | 2004 |
Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Celecoxib; Cell Survival; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Escape Reaction; Exploratory Behavior; Hippocampus; Kainic Acid; Male; Maze Learning; Motor Activity; Neurodegenerative Diseases; Neurons; Psychomotor Performance; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Recovery of Function; Seizures; Sulfonamides; Time Factors | 2004 |
Elimination of zinc-65 from the brain under kainate-induced seizures.
Topics: Animals; Brain; Chlorides; Excitatory Amino Acid Agonists; Kainic Acid; Male; Metalloproteins; Mice; Organ Specificity; Radiography; Seizures; Zinc Compounds; Zinc Radioisotopes | 2004 |
Response to kainic acid injections: changes in staining for zinc, FOS, cell death and glial response in the rat forebrain.
Topics: Animals; Cell Compartmentation; Cell Death; Cytoplasm; Fluoresceins; Fluorescent Dyes; Gliosis; Glutamic Acid; Kainic Acid; Male; Nerve Degeneration; Neurotoxins; Organic Chemicals; Presynaptic Terminals; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission; Synaptic Vesicles; Zinc | 2004 |
Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fructose; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Kainic Acid; Seizures; Topiramate | 2004 |
Comparison of the anticonvulsive activities of organic mono- and dications with their abilities to inhibit NMDA and AMPA glutamate receptors.
Topics: Adamantane; Animals; Anticonvulsants; Brain; Cations, Divalent; Cations, Monovalent; Convulsants; Diamines; Kainic Acid; Male; Mice; N-Methylaspartate; Neurons; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures | 2004 |
[The expression of Smac and XIAP in rat hippocampus following limbic seizure induced by kainic acid injection into amygdaloid nucleus].
Topics: Amygdala; Animals; Caspase 9; Caspases; Complement Membrane Attack Complex; Complement System Proteins; Glycoproteins; Hippocampus; Kainic Acid; Limbic System; Male; Microinjections; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Seizures; X-Linked Inhibitor of Apoptosis Protein | 2004 |
Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cell Nucleus; Death-Associated Protein Kinases; Denervation; Disease Models, Animal; Functional Laterality; Hippocampus; Immunity, Innate; Kainic Acid; Male; Nerve Degeneration; Neurons; Nuclear Proteins; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Seizures; Tumor Suppressor Protein p53 | 2004 |
Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Temperature; Electrocardiography; Electroencephalography; Female; Glial Fibrillary Acidic Protein; Hyperthermia, Induced; Hypoxia; Hypoxia, Brain; Ischemia; Kainic Acid; Rats; Rats, Wistar; Seizures; Time Factors | 2004 |
NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA Fragmentation; Fructose; Hippocampus; Hypoxia, Brain; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Topiramate | 2004 |
Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury.
Topics: Animals; Behavior, Animal; Benzofurans; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Glutathione; Hippocampus; Interleukin-1; Kainic Acid; Lipid Peroxidation; Male; Malondialdehyde; Nerve Degeneration; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2004 |
Regulation of ion channel localization and phosphorylation by neuronal activity.
Topics: Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcimycin; Calcium Channel Blockers; Cell Count; Cells, Cultured; Cyclosporine; Delayed Rectifier Potassium Channels; Dendrites; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ion Channel Gating; Ionophores; Kainic Acid; Membrane Potentials; Neuronal Plasticity; Nitrendipine; Nitriles; Okadaic Acid; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyramidal Cells; Pyrethrins; Rats; Seizures; Shab Potassium Channels; Time Factors; Translocation, Genetic | 2004 |
Role of endonuclease G in neuronal excitotoxicity in mice.
Topics: Animals; Apoptosis; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Mice; Neurons; Protein Transport; Seizures | 2004 |
Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; In Situ Hybridization, Fluorescence; Kainic Acid; Male; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Receptor, trkB; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Status Epilepticus | 2004 |
Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants.
Topics: Aconitate Hydratase; Adenosine Triphosphate; Animals; Astrocytes; Cerebral Cortex; Citrates; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hippocampus; Isocitrates; Kainic Acid; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Vimentin | 2004 |
Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis.
Topics: Animals; Behavior, Animal; Cell Count; Cell Death; Chromosome Mapping; Crosses, Genetic; Excitatory Amino Acid Agonists; Female; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Hippocampus; Histocytochemistry; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurons; Phenotype; Quantitative Trait Loci; Seizures | 2004 |
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
Topics: Animals; Biological Transport; Brain-Derived Neurotrophic Factor; Cell Compartmentation; Convulsants; Dendrites; Dizocilpine Maleate; Electroshock; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Pilocarpine; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Status Epilepticus; Synapses | 2004 |
High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis.
Topics: Animals; Cortical Synchronization; Dentate Gyrus; Electrodes, Implanted; Electroencephalography; Epilepsy; Evoked Potentials; Functional Laterality; Hippocampus; Interneurons; Kainic Acid; Microelectrodes; Rats; Rats, Wistar; Reaction Time; Recurrence; Seizures; Status Epilepticus; Time Factors | 2004 |
Differential expression of phospholipase D isozymes in the hippocampus following kainic acid-induced seizures.
Topics: Amino Acid Sequence; Animals; Female; Gene Expression Regulation, Enzymologic; Hippocampus; Humans; Isoenzymes; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phospholipase D; Rats; Rats, Sprague-Dawley; Seizures | 2004 |
A single oral dose of geranylgeranylacetone attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cell Death; Convulsants; Diterpenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2004 |
[Neurogenesis of dentate granule cells following kainic acid induced seizures in immature rats].
Topics: Animals; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Mossy Fibers, Hippocampal; Neurogenesis; Rats; Seizures | 2004 |
Zac1 is up-regulated in neural cells of the limbic system of mouse brain following seizures that provoke strong cell activation.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Convulsants; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Gene Expression; Genes, Tumor Suppressor; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred ICR; Neurons; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Tissue Distribution; Transcription Factors; Zinc Fingers | 2004 |
Neuropathology of seizures in the immature rabbit.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Fever; Hypotension; Kainic Acid; Muscarinic Agonists; Nerve Degeneration; Neurons; Pilocarpine; Prosencephalon; Rabbits; Seizures | 2004 |
Convulsant and anticonvulsant effects of bupropion in mice.
Topics: Animals; Anticonvulsants; Bupropion; Convulsants; Dose-Response Relationship, Drug; Electroshock; Kainic Acid; Male; Mice; Pentylenetetrazole; Seizures; Survival Rate | 2004 |
Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study.
Topics: Animals; Brain Chemistry; Electroencephalography; Hippocampus; Kainic Acid; Male; Microdialysis; Nociceptin; Opioid Peptides; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Seizures; Statistics, Nonparametric; Thalamus; Time Factors | 2004 |
nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility.
Topics: Animals; Axons; Cell Movement; Cell Survival; Disease Susceptibility; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Pyramidal Cells; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Receptors, Thyroid Hormone; Seizures; Transcription Factors | 2004 |
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.
Topics: Analysis of Variance; Animals; Bicuculline; Blotting, Western; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Electroencephalography; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; In Vitro Techniques; Ion Channels; Kainic Acid; Male; Membrane Potentials; Muscle Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Seizures; Valine | 2004 |
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Differential Threshold; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Female; Hippocampus; Kainic Acid; Kindling, Neurologic; Nervous System Diseases; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures; Time Factors; Video Recording | 2004 |
Anticonvulsant activity of ginseng on seizures induced by chemical convulsants.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Ginsenosides; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; N-Methylscopolamine; Neurons; Panax; Pentylenetetrazole; Phytotherapy; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures | 2005 |
Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.
Topics: Acute Disease; Aggression; Animals; Anticonvulsants; Creatine; Creatinine; Dietary Supplements; Emotions; Hippocampus; Kainic Acid; Learning Disabilities; Male; Neuroprotective Agents; Phenobarbital; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 2004 |
Effects of rapid rewarming on cerebral nitric oxide production and cerebral hemodynamics after hypothermia therapy for kainic acid-induced seizures in immature rabbits.
Topics: Animals; Blood Pressure; Brain; Cerebrovascular Circulation; Electroencephalography; Female; Hippocampus; Hypothermia, Induced; Kainic Acid; Nitric Oxide; Rabbits; Rewarming; Seizures | 2005 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Benzodiazepines; Benzothiadiazines; Camptothecin; Caspase Inhibitors; Cells, Cultured; Cerebellum; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Drug Resistance; Flavoproteins; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Mice, Mutant Strains; N-Methylaspartate; Neurons; Neurotoxins; Proteins; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Seizures | 2005 |
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
Topics: Animals; Dextromethorphan; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Morphinans; Rats; Rats, Sprague-Dawley; Receptors, sigma; Seizures | 2005 |
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy.
Topics: Animals; Blotting, Western; Caspase 6; Caspases; Electrodes, Implanted; Electroencephalography; Enzyme Activation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Kinetics; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2005 |
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables.
Topics: Acetone; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Fixatives; Formaldehyde; Freeze Drying; Frozen Sections; Hydrogen-Ion Concentration; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Polymers; Rats; Rats, Wistar; Seizures; Staining and Labeling; Tissue Fixation | 2005 |
Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.
Topics: Animal Nutritional Physiological Phenomena; Animals; Apoptosis; Cell Death; Clusterin; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Glycoproteins; Hippocampus; Kainic Acid; Ketone Bodies; Ketosis; Male; Mice; Mice, Inbred ICR; Molecular Chaperones; Seizures | 2005 |
Induction of DNA repair proteins, Ref-1 and XRCC1, in adult rat brain following kainic acid-induced seizures.
Topics: Animals; Brain; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Kainic Acid; Male; Rats; Seizures; X-ray Repair Cross Complementing Protein 1 | 2005 |
Differential GABA(A) subunit expression following status epilepticus in seizure-prone and seizure-resistant rats: a putative mechanism for refractory drug response.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Agonists; Gene Expression; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Peptide Fragments; Polymerase Chain Reaction; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Seizures; Species Specificity; Status Epilepticus; Transcription, Genetic | 2005 |
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.
Topics: Amygdala; Animals; Blotting, Western; Cerebral Cortex; Down-Regulation; Electric Stimulation; Kainic Acid; Kindling, Neurologic; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Purinergic P1; Seizures; Time; Up-Regulation; Xanthines | 2005 |
5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Complex Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Kainic Acid; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Seizures; Serotonin Receptor Agonists; Status Epilepticus | 2005 |
Neuroprotection by extract of Petasites japonicus leaves, a traditional vegetable, against oxidative stress in brain of mice challenged with kainic acid.
Topics: Administration, Oral; Animals; Brain; Excitatory Amino Acid Agonists; Glutathione; Humans; Kainic Acid; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Oxidative Stress; Petasites; Plant Extracts; Plant Leaves; Random Allocation; Reactive Oxygen Species; Seizures; Thiobarbituric Acid Reactive Substances | 2006 |
Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.
Topics: Animals; Calbindin 1; Calbindins; Food, Formulated; Hippocampus; Immunohistochemistry; Kainic Acid; Ketone Bodies; Male; Mice; Mice, Inbred ICR; S100 Calcium Binding Protein G; Seizures | 2005 |
Anticonvulsant and neuroprotective effects of the novel nootropic agent nefiracetam on kainic acid-induced seizures in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Kainic Acid; Male; Neuroprotective Agents; Pyrrolidinones; Rats; Rats, Wistar; Seizures; Statistics as Topic; Time Factors | 2005 |
Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats.
Topics: Animals; Blotting, Western; Brain Chemistry; Excitatory Amino Acid Agonists; Female; Glutathione; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Kainic Acid; Lipid Peroxidation; Male; Oxidative Stress; Phenols; Rats; Rats, Wistar; Seizures | 2006 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Epilepsy, Temporal Lobe; Kainic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Substance Withdrawal Syndrome | 2005 |
Gene profiling the response to kainic acid induced seizures.
Topics: Animals; Excitatory Amino Acid Agonists; Extracellular Matrix; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2005 |
Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Calbindin 2; Cell Count; Cell Division; Cell Movement; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Intermediate Filament Proteins; Kainic Acid; Ki-67 Antigen; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Models, Biological; Nerve Tissue Proteins; Nestin; Neuropeptides; Phosphopyruvate Hydratase; S100 Calcium Binding Protein G; Seizures; Stem Cells; Time Factors | 2005 |
The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors.
Topics: Animals; Anticonvulsants; Arginine; Autoradiography; Benzazepines; Electric Stimulation; Electroencephalography; Electrophysiology; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptide Y; Rats; Receptors, Neuropeptide Y; Seizures; Synapses | 2005 |
Analysis of chronic seizure onsets after intrahippocampal kainic acid injection in freely moving rats.
Topics: Animals; Behavior, Animal; Chronic Disease; Cortical Synchronization; Dentate Gyrus; Electrodes, Implanted; Electroencephalography; Entorhinal Cortex; Functional Laterality; Hippocampus; Kainic Acid; Microinjections; Motor Activity; Rats; Rats, Wistar; Seizures; Synaptic Transmission | 2005 |
The seizure-related phenotype of brain-derived neurotrophic factor knockdown mice.
Topics: Alleles; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Convulsants; Electric Stimulation; Electrodes, Implanted; Epilepsy, Tonic-Clonic; Kainic Acid; Kindling, Neurologic; Mice; Mice, Knockout; Pentylenetetrazole; Phenotype; Pilocarpine; Seizures | 2005 |
Previous exposure to (+/-) 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility.
Topics: Animals; Biogenic Monoamines; Brain; Disease Susceptibility; Electroencephalography; Glucose; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Seizures | 2005 |
DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.
Topics: Animals; Benzothiazoles; Cell Death; Cells, Cultured; DNA Damage; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; Entorhinal Cortex; Excitatory Amino Acid Agonists; Heterozygote; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mitochondria; Nerve Degeneration; Neurons; Nuclear Proteins; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2005 |
Congenital brain dysplasias of different genesis can differently affect susceptibility to pilocarpine- or kainic acid-induced seizures in the rat.
Topics: Animals; Behavior, Animal; Brain Diseases; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Female; Gamma Rays; Kainic Acid; Pilocarpine; Pregnancy; Radiation Injuries, Experimental; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2005 |
NKCC1 transporter facilitates seizures in the developing brain.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Cerebral Cortex; Diuretics; Electroencephalography; Gene Expression Regulation, Developmental; Hippocampus; Humans; Immunohistochemistry; Infant; Kainic Acid; Membrane Potentials; Phenobarbital; Rats; Rats, Long-Evans; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2 | 2005 |
Occurrence of bicuculline-, NMDA- and kainic acid-induced seizures in prenatally methamphetamine-exposed adult male rats.
Topics: Animals; Bicuculline; Central Nervous System Stimulants; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Kainic Acid; Male; Methamphetamine; N-Methylaspartate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures | 2005 |
[Expression of multidrug resistance gene and topiramate affect expression of multidrug resistance gene in the hippocampus of spontaneous epileptic rats].
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Fructose; Hippocampus; Kainic Acid; Rats; RNA, Messenger; Seizures; Status Epilepticus; Topiramate | 2005 |
A novel role of circadian transcription factor DBP in hippocampal plasticity.
Topics: Animals; Biological Clocks; Circadian Rhythm; Dependovirus; DNA-Binding Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Glucagon-Like Peptide-1 Receptor; Hippocampus; Kainic Acid; Learning; Memory; Motor Activity; Neuronal Plasticity; Neurons; Rats; Receptors, Glucagon; Seizures; Signal Transduction; Transcription Factors; Transcription, Genetic | 2006 |
Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cell Survival; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Male; Mice; Neurons; Phosphopyruvate Hydratase; Seizures; Time Factors | 2005 |
Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat.
Topics: Animals; Cell Death; Cyclooxygenase 2 Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Lactones; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Seizures; Sulfones | 2005 |
Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin.
Topics: Animals; Apoptosis; Arginine; Curcumin; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Manganese; Neurons; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Seizures | 2006 |
The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors.
Topics: Animals; Base Sequence; Cytoskeletal Proteins; Early Growth Response Protein 1; Early Growth Response Protein 3; Gene Expression Regulation; Hippocampus; Humans; Kainic Acid; Mice; Mice, Knockout; Molecular Sequence Data; Nerve Tissue Proteins; Neuronal Plasticity; Promoter Regions, Genetic; Response Elements; Seizures; Sequence Alignment; Sequence Homology, Nucleic Acid; Synapses; Transcription, Genetic | 2005 |
In vivo evaluation of the effect of zonisamide on the hippocampal redox state during kainic acid-induced seizure status in rats.
Topics: Animals; Anticonvulsants; Electron Spin Resonance Spectroscopy; Hippocampus; Isoxazoles; Kainic Acid; Male; Microdialysis; Nitrogen Oxides; Oxidation-Reduction; Rats; Rats, Wistar; Seizures; Zonisamide | 2005 |
Electron spin resonance assay of ascorbyl radical generation in mouse hippocampal slices during and after kainate-induced seizures.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; Free Radicals; Hippocampus; Isoxazoles; Kainic Acid; Male; Manganese Compounds; Mice; Oxides; Seizures; Zonisamide | 2005 |
Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.
Topics: Animals; Apoptosis; Brain; Disease Susceptibility; G(M1) Ganglioside; Gangliosides; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylgalactosaminyltransferases; Neurons; Neuroprotective Agents; Oligosaccharides; Seizures; Sodium-Calcium Exchanger; Sphingosine; Status Epilepticus; Time Factors | 2005 |
Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.
Topics: Animals; Axons; Cell Death; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Learning; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Memory; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neurons; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Tissue Inhibitor of Metalloproteinase-1 | 2005 |
In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures.
Topics: Animals; Behavior, Animal; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Count; Cell Death; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Docosahexaenoic Acids; Enzyme Activation; Excitatory Amino Acid Agonists; Functional Laterality; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Seizures; Transduction, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury.
Topics: Algorithms; Animals; Artifacts; Brain Injuries; Electroencephalography; Hippocampus; Kainic Acid; Models, Statistical; Predictive Value of Tests; Rats; Seizures; Telemetry | 2006 |
Modulation of neuropeptide Y expression in adult mice does not affect feeding.
Topics: Aging; Alleles; Animals; Appetite; Body Weight; Brain; Feeding Behavior; Gene Expression Regulation; Half-Life; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropeptide Y; RNA, Messenger; Seizures | 2005 |
CA3 axonal sprouting in kainate-induced chronic epilepsy.
Topics: Animals; Axons; Cell Count; Chronic Disease; Coloring Agents; Dentate Gyrus; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Horseradish Peroxidase; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Phytohemagglutinins; Rats; Rats, Sprague-Dawley; Seizures | 2005 |
Site-specific phosphorylation of SCG10 in neuronal plasticity: role of Ser73 phosphorylation by N-methyl D-aspartic acid receptor activation in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Male; Membrane Proteins; Microtubule Proteins; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nerve Growth Factors; Neurons; Pentylenetetrazole; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Time Factors | 2006 |
Cell type-specific changes in spontaneous and minimally evoked excitatory synaptic activity in hippocampal CA1 interneurons of kainate-treated rats.
Topics: Animals; Convulsants; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; Interneurons; Kainic Acid; Kindling, Neurologic; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2006 |
Expression and induction of secretory phospholipase A2 group IB in brain.
Topics: Animals; Antibody Specificity; Brain; Cells, Cultured; Chlorocebus aethiops; COS Cells; Electroshock; Enzyme Induction; Group IB Phospholipases A2; Humans; Kainic Acid; Male; Neurons; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Seizures | 2005 |
Febrile convulsions induced by the combination of lipopolysaccharide and low-dose kainic acid enhance seizure susceptibility, not epileptogenesis, in rats.
Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Body Temperature; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Lipopolysaccharides; Male; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile | 2005 |
Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice.
Topics: Aging; Animals; Brain; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Histocytochemistry; Immunoglobulin G; Immunohistochemistry; Kainic Acid; Lectins; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Seizures; Staining and Labeling | 2006 |
Seizure-induced changes in mitochondrial redox status.
Topics: Animals; Coenzyme A; Cysteine; Disease Models, Animal; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Hippocampus; Kainic Acid; Male; Mitochondria; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Time Factors | 2006 |
Chronic bilateral stimulation of the anterior thalamus of kainate-treated rats increases seizure frequency.
Topics: Acute Disease; Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Disease Models, Animal; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Functional Laterality; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Status Epilepticus; Videotape Recording | 2006 |
Environmental enrichment reverses the impaired exploratory behavior and altered gene expression induced by early-life seizures.
Topics: Animals; Disease Models, Animal; Environment; Epilepsy; Excitatory Amino Acid Agonists; Exploratory Behavior; Gene Expression Regulation, Developmental; Kainic Acid; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2005 |
Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Calcium; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Circular Dichroism; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Conformation; Prosencephalon; Radioligand Assay; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism | 2006 |
Activation of Rho after traumatic brain injury and seizure in rats.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Diazepam; Disease Models, Animal; Drug Interactions; Enzyme Activation; Gene Expression Regulation, Enzymologic; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Seizures | 2006 |
Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice.
Topics: 3-Hydroxybutyric Acid; Animal Feed; Animals; Anticonvulsants; Diet; Immunohistochemistry; Kainic Acid; Ketone Bodies; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Seizures | 2006 |
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Fluoresceins; Forelimb; Functional Laterality; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neuropeptide Y; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344; Seizures; Silver Staining; Time Factors | 2006 |
Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice.
Topics: Administration, Intranasal; Animals; Chlorocebus aethiops; Genetic Therapy; Genetic Vectors; Herpesvirus 2, Human; Hippocampus; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Organ Culture Techniques; PC12 Cells; Rats; Rats, Sprague-Dawley; Seizures; Sequence Deletion; Treatment Outcome; Vero Cells | 2006 |
Repeatable focal seizure suppression: a rat preparation to study consequences of seizure activity based on urethane anesthesia and reversible carotid artery occlusion.
Topics: Anesthetics, Intravenous; Animals; Arterial Occlusive Diseases; Blood Pressure; Carotid Artery Diseases; Disease Models, Animal; Electroencephalography; Electromyography; Functional Laterality; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Urethane | 2006 |
Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage.
Topics: Animals; Blotting, Western; Calcium; Cell Count; Excitatory Amino Acid Agonists; Gene Expression; Genotype; Guanosine Triphosphate; Hippocampus; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Phosphopyruvate Hydratase; Phosphorus Isotopes; Photobleaching; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Staining and Labeling; Time Factors; Transglutaminases | 2006 |
Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2.
Topics: Animals; Arachidonic Acids; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Eicosanoids; Hippocampus; Kainic Acid; Male; Models, Biological; Nitrobenzenes; Rats; Rats, Wistar; Seizures; Sulfonamides | 2006 |
Alterations of taurine in the brain of chronic kainic acid epilepsy model.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures; Taurine | 2006 |
Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways.
Topics: Animals; Cell Nucleus; Drug Design; Fas Ligand Protein; Gene Products, tat; GluK2 Kainate Receptor; Hippocampus; Kainic Acid; Male; MAP Kinase Kinase 4; Membrane Glycoproteins; Neurons; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Tumor Necrosis Factors | 2006 |
Delayed ischemic electrocortical suppression during rapid repeated cerebral ischemia and kainate-induced seizures in rat.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Electrodes; Electroencephalography; Evoked Potentials, Visual; Kainic Acid; Male; Rats; Rats, Wistar; Reperfusion; Seizures; Time Factors | 2006 |
Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice.
Topics: Animals; Dependovirus; DNA, Recombinant; Genetic Vectors; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptide Y; Receptors, Neuropeptide Y; Seizures | 2006 |
Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.
Topics: Animals; Cell Line, Transformed; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Isoenzymes; Kainic Acid; Male; Neostriatum; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Transgenes | 2006 |
Neuroprotection of adenoviral-vector-mediated GDNF expression against kainic-acid-induced excitotoxicity in the rat hippocampus.
Topics: Animals; Blotting, Western; Cell Death; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Gene Expression; Gene Expression Regulation; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2006 |
Role of endothelial nitric oxide synthase in cerebral blood flow changes during kainate seizures: a genetic approach using knockout mice.
Topics: Animals; Brain; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Injections, Intraventricular; Kainic Acid; Mice; Mice, Knockout; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Seizures | 2006 |
Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo.
Topics: Animals; Cerebral Cortex; Dependovirus; Electroencephalography; Fibronectins; Galanin; Gene Expression; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; Infusion Pumps; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2006 |
Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Hormonal; Drug Interactions; Estrogens; Excitatory Amino Acid Agonists; Female; Hippocampus; Immunohistochemistry; Kainic Acid; Medroxyprogesterone Acetate; Ovariectomy; Phosphopyruvate Hydratase; Rats; Seizures | 2006 |
Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures.
Topics: Animals; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kainic Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Seizures; Time Factors; Up-Regulation | 2006 |
Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models.
Topics: Animals; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epilepsy; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Gene Expression Regulation; Genes, Reporter; Hippocampus; Kainic Acid; Male; Microscopy, Confocal; Neuropeptides; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Status Epilepticus; Transcription Factors | 2006 |
Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Neurons; Nitrobenzenes; Rats; Rats, Wistar; Seizures; Sulfonamides | 2006 |
Distinct regulation of metabotropic glutamate receptor (mGluR1 alpha) in the developing limbic system following multiple early-life seizures.
Topics: Age Factors; Animals; Animals, Newborn; Blotting, Western; Drug Administration Schedule; Gene Expression Regulation, Developmental; Immunohistochemistry; Kainic Acid; Limbic System; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Time Factors | 2006 |
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.
Topics: Animals; Anticonvulsants; Azepines; Brain; Caspase 1; Caspase Inhibitors; Disease Models, Animal; Hippocampus; Interleukin-1; Isoquinolines; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prodrugs; Protease Inhibitors; Pyridazines; Rats; Seizures; Tissue Culture Techniques | 2006 |
Responsiveness to kainate in young rats after 2-week zinc deprivation.
Topics: Animals; Calcium; Calcium Signaling; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures; Synapses; Zinc | 2006 |
Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element.
Topics: Animals; Antioxidants; Disease Susceptibility; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Knockout; Mice, Transgenic; Microglia; Nerve Degeneration; Neurons; Neurotoxins; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Response Elements; Seizures | 2006 |
Development- and activity-dependent regulation of SNAP-25 phosphorylation in rat brain.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Female; Hippocampus; Kainic Acid; Male; Neurons; Phosphorylation; Rats; Rats, Wistar; Seizures; Serine; Synaptosomal-Associated Protein 25 | 2006 |
Beneficial effects of FK506 for experimental temporal lobe epilepsy.
Topics: Aggression; Animals; Anticonvulsants; Cell Survival; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Immunosuppressive Agents; In Situ Nick-End Labeling; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Tacrolimus; Trimethyltin Compounds | 2006 |
Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains.
Topics: Animals; Cell Count; Dentate Gyrus; Drug Resistance; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Hybridization, Genetic; Kainic Acid; Male; Mice; Mice, Inbred Strains; Mossy Fibers, Hippocampal; Nerve Degeneration; Organic Chemicals; Phenotype; Quinolinic Acid; Seizures; Species Specificity | 2006 |
Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice.
Topics: Animals; Astrocytes; Brain Injuries; Cell Communication; Cell Survival; Cytoprotection; Disease Models, Animal; Drug Resistance; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Recovery of Function; Seizures; Up-Regulation | 2006 |
Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Blotting, Southern; Blotting, Western; Conditioning, Classical; Cytoskeletal Proteins; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Maze Learning; Memory; Mice; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Seizures; Spatial Behavior; Synapses; Time Factors | 2006 |
Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation.
Topics: Age Factors; Animals; Astrocytes; Behavior, Animal; Blotting, Western; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cell Survival; Dendrites; Doublecortin Domain Proteins; Doublecortin Protein; Female; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neurons; Neuropeptides; Organogenesis; Physical Conditioning, Animal; Seizures | 2006 |
Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Dihydro-beta-Erythroidine; DNA; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Mecamylamine; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Seizures; Transcription Factor AP-1 | 2007 |
Depressive behavior and selective down-regulation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Depressive Disorder; Down-Regulation; Environment; Kainic Acid; Microarray Analysis; Rats; Rats, Long-Evans; Receptors, Serotonin; Seizures; Swimming | 2007 |
Gene expression changes after seizure preconditioning in the three major hippocampal cell layers.
Topics: Animals; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Amplification; Gene Expression; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Muscarinic Agonists; Oligonucleotide Array Sequence Analysis; Organic Chemicals; Pilocarpine; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA; Seizures | 2007 |
Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10.
Topics: Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Erythropoietin; Excitatory Amino Acid Agonists; Hippocampus; Humans; Hypoxia; Hypoxia, Brain; Kainic Acid; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptors.
Topics: Animals; Apoptosis; Disease Susceptibility; Fluoresceins; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Organ Culture Techniques; Organic Chemicals; Prion Proteins; Prions; Receptors, AMPA; RNA, Small Interfering; Seizures; Transfection | 2007 |
A single episode of neonatal seizures permanently alters glutamatergic synapses.
Topics: Animals; Animals, Newborn; Blotting, Western; Cross-Linking Reagents; Dendrites; Disks Large Homolog 4 Protein; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kainic Acid; Maze Learning; Membrane Proteins; Memory; Mental Recall; Mossy Fibers, Hippocampal; Neuronal Plasticity; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Subcellular Fractions; Synapses | 2007 |
Impact of S100B on local field potential patterns in anesthetized and kainic acid-induced seizure conditions in vivo.
Topics: Animals; Electroencephalography; Evoked Potentials; Glial Fibrillary Acidic Protein; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factors; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Seizures; Time Factors | 2007 |
Hippocampal seizure resistance and reduced neuronal excitotoxicity in mice lacking the Cav2.3 E/R-type voltage-gated calcium channel.
Topics: Animals; Calcium Channels, R-Type; Cation Transport Proteins; Electroencephalography; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Seizures | 2007 |
Rats bred for susceptibility to depression-like phenotypes have higher kainic acid-induced seizure mortality than their depression-resistant counterparts.
Topics: Animals; Convulsants; Depression; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Flurothyl; Kainic Acid; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures; Stress, Psychological | 2007 |
BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.
Topics: Animals; Apoptosis; Botulinum Toxins; Caspase 3; Disease Models, Animal; Drug Interactions; Enzyme Activation; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
A quantitative trait locus on chromosome 18 is a critical determinant of excitotoxic cell death susceptibility.
Topics: Animals; Brain; Cell Death; Chromosomes, Mammalian; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Humans; Kainic Acid; Male; Mice; Mice, Congenic; Neurons; Phenotype; Quantitative Trait Loci; Seizures | 2007 |
BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.
Topics: Animals; Apoptosis; Botulinum Toxins; Caspase 3; Disease Models, Animal; Drug Interactions; Enzyme Activation; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Anti-convulsant effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal limbic seizure in rats.
Topics: Animals; Anterior Thalamic Nuclei; Antimetabolites; Autoradiography; Brain Chemistry; Deoxyglucose; Electric Stimulation Therapy; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Agonists; Glucose; Kainic Acid; Limbic System; Male; Neurosurgical Procedures; Rats; Rats, Wistar; Seizures; Stereotaxic Techniques | 2007 |
Differences in two mice strains on kainic acid-induced amygdalar seizures.
Topics: Amygdala; Animals; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures; Species Specificity | 2007 |
Upregulation of synaptotagmin IV protein in kainate-induced seizures.
Topics: Animals; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Synaptotagmins; Up-Regulation | 2007 |
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Convulsants; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Hippocampus; Humans; Kainic Acid; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Phosphorylation; Seizures; tau Proteins | 2007 |
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.
Topics: Age Factors; Amino Acid Transport System X-AG; Animals; Astrocytes; Blotting, Western; Clusterin; Complement Factor H; Cytokines; Disease Models, Animal; Disease Susceptibility; Fluorescent Antibody Technique; Hippocampus; Immunohistochemistry; Inflammation; Kainic Acid; Male; Microglia; Neuroglia; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Up-Regulation | 2007 |
Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Endocannabinoids; Hippocampus; Kainic Acid; MAP Kinase Signaling System; Neuroprotective Agents; Palmitates; Polyunsaturated Alkamides; Rats; Seizures | 2007 |
NPY mediates basal and seizure-induced proliferation in the subcallosal zone.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Hippocampus; Kainic Acid; Male; Mice; Mice, Knockout; Neurons; Neuropeptide Y; Organogenesis; Seizures | 2007 |
Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity.
Topics: Animals; Blotting, Western; Cytoplasmic Granules; Dentate Gyrus; Doublecortin Protein; ELAV Proteins; ELAV-Like Protein 4; Excitatory Amino Acid Agonists; GAP-43 Protein; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Knockout; Neuronal Plasticity; Rats; RNA, Messenger; Seizures | 2007 |
Kainate-induced seizures, oxidative stress and neuronal loss in aging rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Behavior, Animal; Cell Death; Deoxyguanosine; Dose-Response Relationship, Drug; Kainic Acid; Male; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Time Factors | 2007 |
Involvement of p38alpha in kainate-induced seizure and neuronal cell damage.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Electroencephalography; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 14; Mossy Fibers, Hippocampal; Neurons; Phosphorylation; Seizures; Time Factors | 2007 |
Corticotropin-releasing hormone heterogeneous nuclear RNA (hnRNA) and immunoreactivity are induced in extrahypothalamic brain sites by kainic-acid-induced seizures and are modulated by estrogen.
Topics: Animals; Arginine Vasopressin; Brain; Convulsants; Corticotropin-Releasing Hormone; Estradiol; Estrogens; Female; Heterogeneous-Nuclear Ribonucleoproteins; Hypothalamo-Hypophyseal System; Hypothalamus; Immunohistochemistry; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Transcriptional Activation; Up-Regulation | 2007 |
Bcl-w protects hippocampus during experimental status epilepticus.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 7; Caspase 9; Cytochromes c; DNA Fragmentation; Electroencephalography; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Humans; Kainic Acid; Membrane Proteins; Mice; Mice, Mutant Strains; Mitochondria; Neurons; Proteins; Proto-Oncogene Proteins; Seizures; Status Epilepticus | 2007 |
Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.
Topics: Administration, Oral; Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Epilepsy; Food, Fortified; Injections, Intraperitoneal; Kainic Acid; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo.
Topics: Animals; Dependovirus; Gene Expression; Genetic Therapy; Genetic Vectors; Hippocampus; Kainic Acid; Models, Animal; Neuropeptide Y; Peptide Fragments; Rats; Receptors, Neuropeptide Y; Seizures; Time Factors; Transduction, Genetic | 2007 |
Domoic acid preconditioning and seizure induction in young and aged rats.
Topics: Aging; Animals; Kainic Acid; Male; Motor Activity; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation.
Topics: Animals; Convulsants; Kainic Acid; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Transcription, Genetic | 2007 |
Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling.
Topics: Animals; Behavior, Animal; Cell Proliferation; Dendritic Spines; Doublecortin Domain Proteins; Female; Genetic Vectors; Green Fluorescent Proteins; Hippocampus; Kainic Acid; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neurons; Neuropeptides; Organogenesis; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred F344; Retroviridae; Seizures; Time Factors | 2007 |
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Death; Curcumin; Cyclooxygenase 2; Excitatory Amino Acid Agonists; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; Manganese; Neurons; Neurotoxicity Syndromes; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2007 |
Protective effect of topiramate on kainic acid-induced cell death in mice hippocampus.
Topics: Animals; Apoptosis; Benzoxazines; Blotting, Western; Caspase 3; Cell Death; Cell Survival; Disease Models, Animal; Fructose; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Kainic Acid; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Oxazines; Seizures; Topiramate | 2008 |
Time-dependent changes in distribution of basic fibroblast growth factor immunoreactive cells in hippocampus after kainic acid injection in rat pups.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Count; Cell Death; Disease Progression; Down-Regulation; Fibroblast Growth Factor 2; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Time Factors | 2007 |
Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kainic Acid; KATP Channels; Male; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2007 |
Behavioral perseveration and impairment of long-term memory in rats after intrahippocampal injection of kainic acid in subconvulsive dose.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Electroencephalography; Excitatory Amino Acid Agonists; Extinction, Psychological; Hippocampus; Injections; Kainic Acid; Male; Memory Disorders; Rats; Rats, Wistar; Seizures | 2008 |
Region-specific differentiation of embryonic stem cell-derived neural progenitor transplants into the adult mouse hippocampus following seizures.
Topics: Animals; Astrocytes; Biomarkers; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Cellular Senescence; Convulsants; Dentate Gyrus; Embryonic Stem Cells; Excitatory Amino Acid Agonists; Fornix, Brain; Hippocampus; Kainic Acid; Mice; Mice, SCID; Nerve Degeneration; Neurons; Oligodendroglia; Sclerosis; Seizures; Stem Cell Transplantation | 2008 |
Seizure-induced formation of isofurans: novel products of lipid peroxidation whose formation is positively modulated by oxygen tension.
Topics: Aconitum; Animals; Behavior, Animal; Electron Spin Resonance Spectroscopy; F2-Isoprostanes; Furans; Hippocampus; Indoles; Isoprostanes; Kainic Acid; Lipid Peroxidation; Male; Mitochondria; Organometallic Compounds; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2008 |
Kainate seizures cause acute dendritic injury and actin depolymerization in vivo.
Topics: Actins; Animals; Cytoskeleton; Dendrites; Dendritic Spines; Destrin; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Seizures | 2007 |
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Situ Nick-End Labeling; In Vitro Techniques; Ion Channels; Kainic Acid; Potassium Channels; Rats; Rats, Sprague-Dawley; Seizures | 2008 |
Developmental emergence of transient and persistent hippocampal events and oscillations and their association with infant seizure susceptibility.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Cortical Synchronization; Disease Susceptibility; Electrodes, Implanted; Electroencephalography; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Spectrum Analysis | 2007 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Fructosediphosphates; Kainic Acid; Male; Meperidine; Models, Chemical; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2007 |
Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation.
Topics: Animals; Animals, Newborn; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Glycosylation; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunoprecipitation; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Seizures; Tunicamycin | 2008 |
Novel symptomatology and changing epidemiology of domoic acid toxicosis in California sea lions (Zalophus californianus): an increasing risk to marine mammal health.
Topics: Animals; California; Diatoms; Female; Hippocampus; Kainic Acid; Male; Marine Toxins; Neurotoxins; Parahippocampal Gyrus; Poisoning; Sea Lions; Seizures; Time Factors | 2008 |
Embryonic exposure to domoic Acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole.
Topics: Animals; Behavior, Animal; Convulsants; Embryo, Nonmammalian; Female; Kainic Acid; Larva; Male; Microinjections; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Seizures; Swimming; Zebrafish | 2007 |
Effect of myo-inositol on convulsions induced by pentylenetetrazole and kainic acid in rats.
Topics: Animals; Anticonvulsants; Convulsants; Inositol; Kainic Acid; Pentylenetetrazole; Rats; Seizures | 2007 |
Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; bcl-Associated Death Protein; Caspase 3; Cell Death; Cerebral Cortex; Cyclooxygenase 2; Encephalitis; Enzyme Induction; Hippocampus; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2008 |
Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration.
Topics: Animals; Blotting, Western; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p27; DNA; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Seizures | 2007 |
Effects of topiramate on seizure susceptibility in kainate-kindled rats: involvement of peripheral-type benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Excitatory Amino Acid Agonists; Fructose; Hippocampus; Indicators and Reagents; Isoquinolines; Kainic Acid; Kindling, Neurologic; Male; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Synaptosomes; Topiramate | 2008 |
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.
Topics: Adenosine Kinase; Animals; Astrocytes; Brain; Epilepsies, Partial; Kainic Acid; Male; Mice; Mice, Transgenic; Prognosis; Seizures | 2008 |
Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors.
Topics: Analysis of Variance; Animals; Cell Survival; Cyclooxygenase Inhibitors; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Kainic Acid; Male; Mice; Mice, Inbred ICR; Receptors, Prostaglandin; Seizures | 2008 |
TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice.
Topics: Animals; Behavior, Animal; Brain Injuries; Case-Control Studies; CD11b Antigen; Exploratory Behavior; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Motor Activity; Neurodegenerative Diseases; Receptors, Tumor Necrosis Factor, Type I; Seizures | 2008 |
Effects of the ketogenic diet on neurogenesis after kainic acid-induced seizures in mice.
Topics: 3-Hydroxybutyric Acid; Animals; Antimetabolites; Bromodeoxyuridine; Cell Proliferation; Convulsants; Dentate Gyrus; DNA-Binding Proteins; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Seizures; Tissue Fixation | 2008 |
Combined blockade of alpha3beta4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures.
Topics: Animals; Kainic Acid; Male; Nicotinic Antagonists; Rats; Receptors, AMPA; Receptors, Nicotinic; Seizures | 2007 |
Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Movement; Cell Proliferation; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Intermediate Filament Proteins; Kainic Acid; Male; Nerve Tissue Proteins; Nestin; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Semaphorin-3A; Stem Cells | 2008 |
Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice.
Topics: Aging, Premature; Animals; Caspase 3; Cytochromes c; Disease Models, Animal; Enzyme Activation; Glutathione; Glutathione Disulfide; Hippocampus; Ion Channels; Kainic Acid; Lipid Peroxidation; Lipofuscin; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria; Mitochondrial Proteins; Nerve Degeneration; Neurons; Oxidation-Reduction; Oxidative Stress; Proteins; Proto-Oncogene Proteins c-fos; Seizures; Superoxide Dismutase; Time Factors; Uncoupling Protein 2 | 2008 |
Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors.
Topics: Animals; Animals, Newborn; Bicuculline; Electroencephalography; Female; Kainic Acid; Male; Mother-Child Relations; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recurrence; Seizures; Sex Characteristics; Sex Factors; Signal Transduction | 2008 |
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Indoles; Kainic Acid; Leucine; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Neurons; Plant Lectins; Seizures; Stress, Physiological; Valine | 2008 |
Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.
Topics: Animals; Cell Death; Ceramides; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Humans; In Situ Nick-End Labeling; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2008 |
Expression of Kir2.1 channels in astrocytes under pathophysiological conditions.
Topics: Animals; Astrocytes; Excitatory Amino Acid Agonists; Hippocampus; Homeostasis; Kainic Acid; Male; Mice; Mice, Inbred DBA; Patch-Clamp Techniques; Potassium; Potassium Channels, Inwardly Rectifying; Protein Subunits; Seizures | 2008 |
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus.
Topics: Algorithms; Animals; Blood-Brain Barrier; Chlorides; Chronic Disease; Contrast Media; Data Interpretation, Statistical; Dentate Gyrus; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gadolinium; Gliosis; Kainic Acid; Magnetic Resonance Imaging; Male; Manganese Compounds; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2008 |
Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.
Topics: Acetylcholine; Acetylcholinesterase; Alternative Splicing; Animals; Chronic Disease; Convulsants; Electrophysiology; Entorhinal Cortex; Epilepsy; Gene Expression; Kainic Acid; Microelectrodes; Muscarinic Antagonists; Nicotinic Antagonists; Organ Culture Techniques; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2008 |
Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice.
Topics: Aging; Animals; Astrocytes; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Degeneration; Nerve Growth Factors; Seizures; Sex Characteristics | 2008 |
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Topics: Analysis of Variance; Animals; Autoradiography; Celecoxib; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme-Linked Immunosorbent Assay; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Seizures; Statistics, Nonparametric; Sulfonamides; Synaptic Transmission | 2008 |
Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure.
Topics: Animals; Cyclic GMP; Hippocampus; Homeodomain Proteins; Kainic Acid; Male; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Seizures; Signal Transduction | 2008 |
Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Mutation; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Reaction Time; Receptors, Somatostatin; Seizures | 2008 |
Chemoconvulsant model of chronic spontaneous seizures.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroshock; Excitatory Amino Acid Agonists; Kainic Acid; Male; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2005 |
Effect of age on kainate-induced seizure severity and cell death.
Topics: Aging; Animals; Cell Count; Cell Death; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Seizures; Species Specificity | 2008 |
Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures.
Topics: 14-3-3 Proteins; Animals; Biomarkers; Hippocampus; Kainic Acid; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Seizures | 2008 |
A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamates; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Fructose; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Topiramate; Video Recording | 2008 |
Differential 24 h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures.
Topics: Animals; Bromodeoxyuridine; Cell Lineage; Cell Survival; Dentate Gyrus; Environment; Excitatory Amino Acid Agonists; Female; Hippocampus; Homeodomain Proteins; Immunohistochemistry; Kainic Acid; Mice; Mice, Transgenic; Motor Activity; Neurons; Seizures; Stem Cells; Tumor Suppressor Proteins | 2008 |
Atropine reversal of kainic acid-induced decrease in the leptazol convulsive threshold.
Topics: Animals; Atropine; Kainic Acid; Male; Mice; Parasympathetic Nervous System; Pentylenetetrazole; Pyrrolidines; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1981 |
Intrahippocampal bethanechol in rats: behavioural, electroencephalographic and neuropathological correlates.
Topics: Acetylcholine; Animals; Automatism; Behavior, Animal; Bethanechol; Bethanechol Compounds; Electroencephalography; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Seizures | 1983 |
Changes in hippocampal immunoreactive dynorphin and neoendorphin content following intra-amygdalar kainic acid-induced seizures.
Topics: Amygdala; Animals; Dynorphins; Endorphins; Kainic Acid; Kinetics; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Seizures | 1983 |
Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Septal Nuclei; Synaptic Transmission | 1983 |
Kainic acid induced seizures: neurochemical and histopathological changes.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Cerebral Cortex; Corpus Striatum; Hippocampus; Kainic Acid; Limbic System; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neurotransmitter Agents; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1983 |
Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid.
Topics: Allylglycine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Male; Neurotransmitter Agents; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Taurine | 1984 |
Kainate and glutamate neurotoxicity in dependence on the postnatal development with special reference to hippocampal neurons.
Topics: Age Factors; Animals; Glutamates; Glutamic Acid; Hippocampus; Injections, Intraventricular; Kainic Acid; Movement Disorders; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1984 |
Recurrent convulsions and hippocampal [Met5]-enkephalin content.
Topics: Animals; Electroshock; Endorphins; Enkephalin, Methionine; Enkephalins; Hippocampus; Injections; Kainic Acid; Male; Neurons; Rats; Recurrence; Seizures; Substance P; Time Factors | 1980 |
The role of the substantia nigra in the control of amygdaloid paroxysmal activity.
Topics: Amygdala; Animals; Cats; Caudate Nucleus; Electroshock; Kainic Acid; Seizures; Substantia Nigra | 1981 |
Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Recurrence; Seizures; Species Specificity; Time Factors | 1982 |
Positron emission tomography in a case of experimental focal epilepsy in the baboon.
Topics: Animals; Brain; Deoxy Sugars; Deoxyglucose; Epilepsies, Partial; Fluorodeoxyglucose F18; Kainic Acid; Models, Biological; Papio; Seizures; Status Epilepticus; Tomography, Emission-Computed | 1982 |
Intracortical and intrahippocampal injections of kainic acid in developing rats: an electrographic study.
Topics: Animals; Cerebral Cortex; Electroencephalography; Hippocampus; Injections; Kainic Acid; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures | 1983 |
Sustained limbic seizures induced by intraamygdaloid kainic acid in the baboon: Symptomatology and neuropathological consequences.
Topics: Amygdala; Animals; Cerebral Cortex; Electroencephalography; Evoked Potentials; Kainic Acid; Limbic System; Nerve Degeneration; Papio; Pyrrolidines; Seizures; Synaptic Transmission | 1980 |
Evidence from lesion studies for epileptogenic and non-epileptogenic neurotoxic interactions between kainic acid and excitatory innervation.
Topics: Afferent Pathways; Animals; Denervation; Hippocampus; Kainic Acid; Limbic System; Nerve Fibers; Neurons; Pyrrolidines; Rats; Seizures; Synaptic Transmission | 1981 |
Proconvulsant effects in baboons of beta-carboline, a putative endogenous ligand for benzodiazepine receptors.
Topics: Amygdala; Animals; Benzodiazepines; Carbolines; Indoles; Kainic Acid; Ligands; Light; Papio; Receptors, Drug; Receptors, GABA-A; Seizures | 1981 |
Naloxone blocks morphine enhancement of kainic acid neurotoxicity.
Topics: Animals; Brain; Kainic Acid; Male; Morphine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1982 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Seizures | 1982 |
A comparative histological and electrophysiological study of some neurotoxins in the rat hippocampus.
Topics: Afferent Pathways; Animals; Cycloleucine; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1982 |
Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity.
Topics: Animals; Electric Conductivity; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Pyrrolidines; Rats; Seizures; Synapses; Synaptic Transmission | 1983 |
Kainic acid seizure syndrome and binding sites in developing rats.
Topics: Amygdala; Animals; Binding Sites; Hippocampus; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Syndrome | 1984 |
Kainic acid derivatives with anticonvulsant activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Female; Kainic Acid; Male; Mice; Mice, Inbred DBA; Pyrrolidines; Seizures | 1984 |
Are convulsant and toxic properties of folates of the kainate type?
Topics: Amygdala; Animals; Behavior, Animal; Convulsants; Folic Acid; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures | 1983 |
Increased cerebrovascular permeability to protein during systemic kainic acid seizures.
Topics: Animals; Blood Proteins; Blood-Brain Barrier; Female; Horseradish Peroxidase; Kainic Acid; Nerve Tissue Proteins; Pyrrolidines; Rats; Seizures | 1984 |
Seizure activity and lesions after intrahippocampal quinolinic acid injection.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Epilepsy; Hippocampus; Injections; Kainic Acid; Male; Pyridines; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1984 |
Regional brain glucose metabolism in chemically-induced seizures in the rat.
Topics: Allylglycine; Animals; Bicuculline; Blood Glucose; Brain; Convulsants; Deoxyglucose; Energy Metabolism; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Kainic-acid-induced seizures: a developmental study.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid | 1981 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Phenytoin; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1981 |
Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ethosuximide; Guinea Pigs; Hippocampus; Kainic Acid; Phenobarbital; Phenytoin; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1982 |
Blood-brain barrier changes with kainic acid-induced limbic seizures.
Topics: Aminoisobutyric Acids; Animals; Autoradiography; Blood-Brain Barrier; Carbon Radioisotopes; Kainic Acid; Male; Permeability; Rats; Rats, Inbred Strains; Seizures | 1983 |
GABAergic and cholinergic indices in various regions of rat brain after intracerebral injections of folic acid.
Topics: 4-Aminobutyrate Transaminase; Amygdala; Animals; Brain; Carboxy-Lyases; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Folic Acid; Frontal Lobe; Glutamate Decarboxylase; Kainic Acid; Limbic System; Male; Neurons; Rats; Rats, Inbred Strains; Seizures; Thalamus; Transaminases | 1983 |
Amygdaloid lesion increases the toxicity of intrahippocampal kainic acid injection and reduces the late occurrence of spontaneous recurrent seizures in rats.
Topics: Amygdala; Animals; Dominance, Cerebral; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Hippocampus; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Recurrence; Seizures | 1983 |
Intra-amygdaloid injections of kainic acid: regional metabolic changes and their relation to the pathological alterations.
Topics: Amygdala; Animals; Autoradiography; Blood Glucose; Brain Mapping; Deoxyglucose; Energy Metabolism; Evoked Potentials; Kainic Acid; Limbic System; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures | 1983 |
Different neuropathological effects of intrahippocampal injections of kainic acid and tetanus toxin.
Topics: Animals; Hippocampus; Kainic Acid; Male; Neurotoxins; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Tetanus Toxin | 1983 |
Development of epileptic activity and its correlation with GABAergic and glutamergic systems during brain maturation in the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Brain; Diazepam; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Kainic Acid; Rats; Seizures; Strychnine; Urethane | 1983 |
Behavioral and electrographic patterns induced by systemic administration of kainic acid in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain; Cerebral Cortex; Electroencephalography; Female; Hippocampus; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures | 1983 |
Limbic epilepsy produced by intra-amygdaloid kainic acid microinjections in cats.
Topics: Amygdala; Animals; Anticonvulsants; Cats; Electric Stimulation; Female; Kainic Acid; Limbic System; Male; Microinjections; Pyrrolidines; Seizures | 1983 |
Epidural kainate, but not ibotenate, produces lesions in local and distant regions of the brain. A comparison of the intracerebral actions of kainic acid and ibotenic acid.
Topics: Animals; Brain; Brain Mapping; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Ibotenic Acid; Kainic Acid; Neurons; Oxazoles; Pyrrolidines; Rats; Seizures | 1982 |
Sparing of rhythmic slow activity (RSA or theta) in two hippocampal generators after kainic acid CA3 and CA4 lesions.
Topics: Animals; Atropine; Dominance, Cerebral; Electroencephalography; Evoked Potentials; Hippocampus; Kainic Acid; Male; Muridae; Nerve Fibers; Neural Pathways; Neurons; Pyrrolidines; Seizures; Theta Rhythm | 1982 |
Excitatory amino acid analogues: neurotoxicity and seizures.
Topics: Amino Acids; Animals; Choline O-Acetyltransferase; Corpus Striatum; Electroencephalography; Glutamate Decarboxylase; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Rats; Rats, Inbred Strains; Seizures | 1982 |
Anticonvulsant action of phenobarbital, diazepam, carbamazepine, and diphenylhydantoin in the electroshock test in mice after lesion of hippocampal pyramidal cells with intracerebroventricular kainic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Electroshock; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Pyrrolidines; Rats; Seizures | 1982 |
Relationship between the striatal system and amygdaloid paroxysmal activity.
Topics: Amygdala; Animals; Cats; Caudate Nucleus; Corpus Striatum; Electric Stimulation; Kainic Acid; Seizures; Substantia Nigra | 1982 |
Dipiperidinoethane neurotoxicity clarified.
Topics: Amygdala; Animals; Biotransformation; Convulsants; Kainic Acid; Oxotremorine; Piperidines; Rats; Receptors, Cholinergic; Seizures; Structure-Activity Relationship | 1982 |
Intrahippocampal kainic acid, seizures and local neuronal degeneration: relationships assessed in unanesthetized rats.
Topics: Animals; Brain Diseases; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures | 1982 |
Kainic acid-induced limbic seizures: electrophysiologic studies.
Topics: Animals; Electroencephalography; Electrophysiology; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; Rats; Seizures | 1981 |
Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.
Topics: Animals; Anticonvulsants; Brain; Caudate Nucleus; Electroencephalography; Evoked Potentials; Kainic Acid; Male; Muscimol; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Taurine | 1982 |
Antagonism of intrastriatal and intravenous kainic acid by 1-nuciferine: comparison with various anticonvulsants and GABAmimetics.
Topics: Animals; Aporphines; Baclofen; Behavior, Animal; Choline O-Acetyltransferase; Corpus Striatum; Diazepam; Excitatory Amino Acid Antagonists; Haloperidol; Injections; Kainic Acid; Male; Phenobarbital; Pyrrolidines; Rats; Seizures | 1980 |
Kainic acid neurotoxicity and seizures.
Topics: Animals; Corpus Striatum; Electroencephalography; Glutamate Decarboxylase; Hippocampus; Injections; Kainic Acid; Male; Nervous System Diseases; Pyrrolidines; Rats; Seizures | 1981 |
Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy.
Topics: Animals; Bicuculline; Brain; Deoxy Sugars; Deoxyglucose; Electric Conductivity; Glucose; Kainic Acid; Male; Organ Specificity; Pentylenetetrazole; Pyrrolidines; Rats; Seizures | 1981 |
Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates.
Topics: Animals; Brain; Deoxyglucose; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Kainic Acid; Limbic System; Motor Activity; Pyrrolidines; Rats; Seizures | 1981 |
Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid.
Topics: Animals; Corpus Striatum; Folic Acid; Kainic Acid; Male; Pyrrolidines; Rats; Seizures | 1981 |
The effect of epileptiform discharges evoked by intrahippocampal injection of kainic acid on cholinergic and catecholaminergic hippocampal afferents.
Topics: Acetylcholinesterase; Afferent Pathways; Animals; Catecholamines; Cholinergic Fibers; Evoked Potentials; Hippocampus; Kainic Acid; Locus Coeruleus; Microscopy, Fluorescence; Monoamine Oxidase; Norepinephrine; Pyrrolidines; Rabbits; Seizures; Septal Nuclei | 1981 |
[A new model of epilepsy--a small epileptic focus by microinjection of kainic acid into the unilateral hippocampus in cats (author's transl)].
Topics: Animals; Cats; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Microinjections; Pyrrolidines; Seizures | 1981 |
Circling behavior following unilateral kainic acid injections into rat striatum.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Female; Glutamates; Haloperidol; Hydroxydopamines; Kainic Acid; Motor Activity; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Rotation; Seizures; Substantia Nigra | 1981 |
Changes of hippocampal Met-enkephalin content after recurrent motor seizures.
Topics: Animals; Endorphins; Enkephalins; Functional Laterality; Hippocampus; Kainic Acid; Male; Phenobarbital; Pyrrolidines; Rats; Seizures; Time Factors | 1980 |
The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid.
Topics: Afferent Pathways; Amygdala; Animals; Brain; Brain Mapping; Corpus Striatum; Diazepam; Dominance, Cerebral; Electroencephalography; Evoked Potentials; Glutamates; Hippocampus; Injections, Intraventricular; Kainic Acid; Neurons; Pyrrolidines; Rats; Seizures; Septum Pellucidum | 1980 |
Locomotor activity, exploration and spatial alternation learning in rats with striatal injections of kainic acid.
Topics: Animals; Conditioning, Operant; Corpus Striatum; Dextroamphetamine; Discrimination Learning; Exploratory Behavior; Kainic Acid; Male; Motor Activity; Neurons; Pyrrolidines; Rats; Seizures; Space Perception | 1980 |
Effects of anticonvulsants and glutamate antagonists on the convulsive action of kainic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bemegride; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Pentylenetetrazole; Picrotoxin; Pyrrolidines; Seizures | 1980 |
Effects of sustained seizures produced by intrahippocampal injection of kainic acid on noradrenergic neurons: evidence for local control of norepinephrine release.
Topics: Animals; Barbiturates; Behavior, Animal; Brain Chemistry; Electroencephalography; gamma-Aminobutyric Acid; Hippocampus; Injections; Kainic Acid; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Pyrrolidines; Rats; Seizures | 1980 |
Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study.
Topics: Amygdala; Animals; Brain; Histocytochemistry; Kainic Acid; Neurons; Organ Specificity; Pyrrolidines; Rats; Seizures; Time Factors | 1980 |
Systemic dipiperidinoethane mimics the convulsant and neurotoxic actions of kainic acid.
Topics: Animals; Behavior, Animal; Diazepam; Hippocampus; Kainic Acid; Male; Piperidines; Pyrrolidines; Rats; Seizures | 1980 |
Spontaneously recurrent seizures after intracerebral injections of kainic acid in rat: a possible model of human temporal lobe epilepsy.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Male; Pyrrolidines; Rats; Seizures; Stereotyped Behavior; Temporal Lobe | 1980 |
Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus.
Topics: Animals; Behavior, Animal; Dentate Gyrus; DNA; Enkephalins; Gene Expression Regulation; Genes, fos; Genes, jun; Kainic Acid; Male; Opioid Peptides; Pentylenetetrazole; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Seizures; Transcription Factor AP-1; Transcription Factors | 1995 |
Seizure-induced activation of enkephalin- and somatostatin-synthesizing neurons.
Topics: Animals; Brain; Enkephalins; Gene Expression Regulation; Kainic Acid; Male; Neurons; Organ Specificity; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Seizures; Somatostatin | 1995 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Seizures | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; Drug Synergism; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Receptors, Glutamate; Seizures | 1993 |
aFGF, bFGF and flg mRNAs show distinct patterns of induction in the hippocampus following kainate-induced seizures.
Topics: Animals; Base Sequence; Diazepam; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Hippocampus; In Situ Hybridization; Kainic Acid; Molecular Sequence Data; Neurons; Oligonucleotide Probes; Polymerase Chain Reaction; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; RNA-Directed DNA Polymerase; RNA, Messenger; Seizures; Sulfur Radioisotopes; Up-Regulation | 1994 |
The role of nitric oxide in the kainate-induced seizures in mice.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Dose-Response Relationship, Drug; Kainic Acid; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Seizures | 1994 |
Phosphorylation and activation of mitogen-activated protein kinase by kainic acid-induced seizure in rat hippocampus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Hippocampus; Immunoblotting; Immunosorbent Techniques; Kainic Acid; Kinetics; Male; Phosphorylation; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Seizures; Tyrosine | 1994 |
Attenuation of hippocampal kainic acid-induced seizures by substance P treatment.
Topics: Animals; Fetal Tissue Transplantation; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Substance P | 1994 |
Changes in glutamate receptor and proenkephalin gene expression after kindled seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Blotting, Northern; Brain; Cerebellum; DNA Probes; Electric Stimulation; Enkephalins; Frontal Lobe; Gene Expression; Hippocampus; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Macromolecular Substances; Male; Organ Specificity; Parietal Lobe; Protein Precursors; Rats; Receptors, GABA; Receptors, Glutamate; RNA, Messenger; Seizures; Transcription, Genetic | 1994 |
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhibitors; Indazoles; Kainic Acid; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
NBQX prevents contralateral but not ipsilateral seizure-induced cytotoxicity of kainate but not AMPA-reversal at high doses of NBQX.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures | 1994 |
Neuroprotective effect of acidic fibroblast growth factor on seizure-associated brain damage.
Topics: Animals; Brain; Brain Damage, Chronic; Fibroblast Growth Factor 1; Hippocampus; Kainic Acid; Nerve Degeneration; Organ Specificity; Rats; Rats, Wistar; Recombinant Proteins; Seizures | 1994 |
Nitric oxide promotes seizure activity in kainate-treated rats.
Topics: Amino Acid Oxidoreductases; Animals; Diazepam; Ditiocarb; Indazoles; Iron; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Seizures | 1994 |
Lack of involvement of nitric oxide in the mechanisms of seizures and hippocampal damage produced by kainate and ouabain in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Brain Damage, Chronic; Hippocampus; Kainic Acid; Lithium Chloride; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ouabain; Rats; Rats, Wistar; Seizures; Tacrine | 1995 |
Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Drug Synergism; Injections, Intraperitoneal; Kainic Acid; Male; Nitric Oxide Synthase; Nitroarginine; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
Effects of kainic acid induced seizures on immediate early gene expression in mice with a targeted mutation of the CREB gene.
Topics: Activating Transcription Factor 2; Animals; Cyclic AMP Response Element-Binding Protein; Gene Expression; Genes, fos; Genes, Immediate-Early; Genes, jun; Immunohistochemistry; Kainic Acid; Limbic System; Mice; Mutagenesis, Site-Directed; RNA; Seizures; Transcription Factors | 1995 |
Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat.
Topics: Adrenergic Fibers; Amygdala; Animals; Cell Count; Chick Embryo; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Nerve Growth Factors; Nerve Tissue Proteins; Rats; Rats, Inbred F344; Recombinant Proteins; Seizures; Thalamus | 1995 |
Effect of kainate-induced seizure activity on the polyamine interconversion pathway in juvenile rat brain.
Topics: Acetylation; Age Factors; Animals; Cerebral Cortex; Epilepsy; Hippocampus; Kainic Acid; Polyamines; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
Zonisamide: electrophysiological and metabolic changes in kainic acid-induced limbic seizures in rats.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Electroencephalography; Glucose; Isoxazoles; Kainic Acid; Limbic System; Rats; Rats, Wistar; Seizures; Status Epilepticus; Zonisamide | 1995 |
Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.
Topics: Animals; Drug Resistance; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Nerve Degeneration; Seizures; Tissue Plasminogen Activator | 1995 |
Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration.
Topics: Animals; Blotting, Northern; Brain; Cathepsin D; Cerebral Cortex; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Wistar; RNA, Messenger; Seizures; Time Factors | 1995 |
Seizure susceptibility in immature rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate.
Topics: Age Factors; Animals; Bicuculline; Body Weight; Brain; Disease Models, Animal; Female; Humans; Infant, Newborn; Kainic Acid; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Wistar; Seizures | 1995 |
Kainic acid-induced seizures and brain damage in the rat: role of calcium homeostasis.
Topics: Animals; Behavior, Animal; Body Temperature; Brain Diseases; Calcium; Calcium Channels; Dantrolene; Homeostasis; Ion Channel Gating; Kainic Acid; Male; Nimodipine; Pyramidal Cells; Rats; Rats, Wistar; Seizures | 1995 |
Effect of inhibiting NO synthesis on hippocampal extracellular glutamate concentration in seizures induced by kainic acid.
Topics: Animals; Arginine; Blood Glucose; Disease Models, Animal; Electrophysiology; Glutamic Acid; Hippocampus; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Seizures; Time Factors | 1995 |
Differential susceptibility to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Seizures; Species Specificity | 1995 |
Functional effects of D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2 and differential changes in somatostatin receptor messenger RNAs, binding sites and somatostatin release in kainic acid-treated rats.
Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding Sites; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; RNA, Messenger; Seizures; Somatostatin | 1995 |
Oxygen free radicals in rat limbic structures after kainate-induced seizures.
Topics: Animals; Catalase; Cerebral Cortex; Female; Free Radicals; Glutathione Peroxidase; Hippocampus; Kainic Acid; Limbic System; Lipid Peroxidation; Male; Malondialdehyde; Nerve Tissue Proteins; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Superoxide Dismutase | 1995 |
Neonatal caffeine exposure and seizure susceptibility in adult rats.
Topics: Animals; Animals, Newborn; Bicuculline; Brain; Caffeine; Female; Kainic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Receptors, Purinergic P1; Seizures; Sex Factors; Strychnine | 1995 |
Seizures induced by homocysteine in rats during ontogenesis.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acids; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Seizures | 1995 |
Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss.
Topics: Animals; Chlorocebus aethiops; Gene Expression; Gene Transfer Techniques; Genetic Vectors; Glucose Transporter Type 1; Hippocampus; Hypoglycemia; In Vitro Techniques; Kainic Acid; Male; Monosaccharide Transport Proteins; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Simplexvirus; Vero Cells | 1995 |
The cardiac glycoside ouabain potentiates excitotoxic injury of adult neurons in rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Hippocampus; Kainic Acid; Limbic System; Nerve Degeneration; Neurons; Ouabain; Rats; Seizures; Sodium-Potassium-Exchanging ATPase | 1995 |
Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate.
Topics: Animals; Autoradiography; Brain-Derived Neurotrophic Factor; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Nerve Growth Factors; Nerve Tissue Proteins; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; RNA, Complementary; RNA, Messenger; Seizures | 1995 |
Temporalspatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizures.
Topics: Animals; Base Sequence; Gene Expression; Genes, fos; Heme Oxygenase (Decyclizing); HSP70 Heat-Shock Proteins; Interleukin-1; Kainic Acid; Male; Metallothionein; Molecular Sequence Data; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Seizures | 1995 |
Neurochemical characterization of preprotachykinin B(50-79) immunoreactivity in the rat.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Kainic Acid; Male; Molecular Sequence Data; Neurokinin B; Organ Specificity; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Binding, Competitive; Brain; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Naltrexone; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model.
Topics: Animals; Electroencephalography; Hippocampus; Kainic Acid; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Seizures; Synapses; Time Factors | 1993 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
Regional and temporal profiles of calcium accumulation and glial fibrillary acidic protein levels in rat brain after systemic injection of kainic acid.
Topics: Animals; Astrocytes; Autoradiography; Biomarkers; Brain; Calcium; Calcium Isotopes; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Neurotoxins; Rats; Rats, Wistar; Seizures; Time Factors | 1994 |
Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor.
Topics: Animals; Brain-Derived Neurotrophic Factor; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nerve Growth Factors; Nerve Tissue Proteins; Neuronal Plasticity; Neurotrophin 3; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, trkA; Receptor, trkC; Receptors, Nerve Growth Factor; RNA, Messenger; Seizures; Time Factors | 1995 |
Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Sequence; Animals; Antibodies; Binding Sites; Cell Line; Cells, Cultured; Electric Conductivity; Embryo, Mammalian; Humans; Immunoglobulin G; Kainic Acid; Kidney; Mice; Molecular Sequence Data; Neurons; Peptide Fragments; Receptors, Glutamate; Seizures; Transfection | 1995 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Early and transient increase of rat hippocampal blood-brain barrier permeability to amino acids during kainic acid-induced seizures.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Disease Models, Animal; Hippocampus; Kainic Acid; Male; Permeability; Rats; Rats, Wistar; Seizures | 1995 |
Rat strain and age differences in kainic acid induced seizures.
Topics: Aging; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Kainic Acid; Male; Rats; Rats, Inbred F344; Rats, Inbred WF; Rats, Sprague-Dawley; Seizures; Species Specificity; Status Epilepticus | 1995 |
Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.
Topics: Animals; Blotting, Western; Disease Models, Animal; Epilepsy; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Stress, Physiological; Temporal Lobe | 1995 |
Kainic acid-induced heat shock protein-70, mRNA and protein expression is inhibited by MK-801 in certain rat brain regions.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Brain Mapping; Dizocilpine Maleate; HSP70 Heat-Shock Proteins; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1995 |
Depletion of cortical cholecystokinin levels after excitotoxin injection into the nucleus basalis: sensitivity to MK-801.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Frontal Lobe; Hippocampus; Immunoblotting; Kainic Acid; Male; Nucleus Accumbens; Potassium; Radioimmunoassay; Rats; RNA, Messenger; Seizures; Temporal Bone | 1995 |
Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Electric Stimulation; Homovanillic Acid; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures | 1994 |
Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats.
Topics: Animals; Antibodies; Chronic Disease; Disease Susceptibility; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurons; Neuropeptide Y; Pentylenetetrazole; Potassium Chloride; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
The pattern of neuronal injury following seizures induced by intranigral kainic acid.
Topics: Animals; Behavior, Animal; Cell Death; Electroencephalography; Histocytochemistry; HSP70 Heat-Shock Proteins; Injections; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1994 |
Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells.
Topics: Animals; Astrocytes; Cell Division; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Nerve Tissue Proteins; Neuroglia; Neurons; Oligodendroglia; Rats; Rats, Wistar; Seizures | 1994 |
Sensitivity of the circadian rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor binding.
Topics: Animals; Circadian Rhythm; Corticosterone; Hippocampus; Kainic Acid; Male; Mice; Mineralocorticoid Receptor Antagonists; Receptors, Mineralocorticoid; Seizures; Spironolactone; Time Factors | 1994 |
Deep prepiriform cortex modulates kainate-induced hippocampal injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Electroencephalography; Excitatory Amino Acids; GABA Antagonists; Hippocampus; Kainic Acid; Male; Neural Pathways; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission | 1994 |
Dynamic changes in the composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death.
Topics: Animals; Brain; Cell Death; DNA-Binding Proteins; Kainic Acid; Nerve Tissue Proteins; Rats; Rats, Wistar; Seizures; Transcription Factor AP-1 | 1994 |
Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal.
Topics: 4-Aminopyridine; Aminophylline; Animals; Ethanol; Kainic Acid; Male; Mice; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1995 |
Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements.
Topics: Animals; beta-Galactosidase; Binding Sites; Cloning, Molecular; Embryo, Mammalian; Gene Expression; Gene Expression Regulation; Genes, fos; Glial Fibrillary Acidic Protein; Kainic Acid; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mutagenesis, Site-Directed; Neurons; Point Mutation; Polymerase Chain Reaction; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Seizures; Telencephalon; Transcription Factor AP-1; Transcription, Genetic | 1995 |
Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro.
Topics: Animals; Astrocytes; Cell Death; Clusterin; Complement C1q; Complement C4; Gene Expression Regulation; Glutamic Acid; Glycoproteins; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Chaperones; Nerve Tissue Proteins; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1994 |
Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection.
Topics: Animals; Gene Expression; Hippocampus; In Situ Hybridization; Interneurons; Kainic Acid; Kinetics; Male; Neuropeptide Y; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1994 |
Kainic acid inhibits protein amino acid incorporation in select rat brain regions.
Topics: Amino Acids; Animals; Autoradiography; Brain; Kainic Acid; Male; Methionine; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution | 1994 |
Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Base Sequence; Brain; Calcium-Binding Proteins; Cell Line; Colforsin; DNA Primers; Gene Expression; Gene Library; Genes, Immediate-Early; Hippocampus; Kainic Acid; Male; Membrane Glycoproteins; Membrane Potentials; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Oligonucleotide Probes; Organ Specificity; PC12 Cells; Pheochromocytoma; Polymerase Chain Reaction; Potassium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sequence Homology, Amino Acid; Synaptotagmins; Tetradecanoylphorbol Acetate | 1995 |
Kainic acid induced seizures cause a marked increase in the expression of neurokinin-3 receptor mRNA in the rat cerebellum.
Topics: Animals; Brain; Cerebellum; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; RNA, Messenger; Seizures; Time Factors; Tissue Distribution | 1994 |
N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Interactions; Female; Glutamates; Glutamic Acid; Guanidines; Kainic Acid; Ketamine; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Succinates | 1993 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
[Electrophysiological and behavioral features of septal seizures in cats--experimental sham-rage seizures induced by injection of kainic acid].
Topics: Animals; Behavior, Animal; Brain; Cats; Disease Models, Animal; Electroencephalography; Humans; Kainic Acid; Monitoring, Physiologic; Seizures | 1994 |
The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam.
Topics: Animals; Behavior, Animal; Cycloserine; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kainic Acid; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures; Strychnine | 1994 |
Neural tropomodulin: developmental expression and effect of seizure activity.
Topics: Animals; Base Sequence; Blotting, Northern; Blotting, Western; Brain; Brain Chemistry; Carrier Proteins; Electrophoresis, Polyacrylamide Gel; Hippocampus; In Situ Hybridization; Kainic Acid; Microfilament Proteins; Molecular Sequence Data; Myocardium; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Tropomodulin | 1994 |
Differential effects of dexamethasone on the induction of c-fos, zif-268 and ornithine decarboxylase by excitotoxin.
Topics: Cerebral Cortex; Dexamethasone; DNA-Binding Proteins; Enzyme Induction; Genes, fos; Kainic Acid; Ornithine Decarboxylase; RNA, Messenger; Seizures; Transcription Factors | 1994 |
Seizure-induced expression of G proteins in the rat hippocampus.
Topics: Animals; Autoradiography; Gene Expression; GTP-Binding Proteins; Hippocampus; In Situ Hybridization; Kainic Acid; Macromolecular Substances; Male; Neurons; Oligonucleotide Probes; Rats; Rats, Wistar; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1994 |
Dapsone attenuates kainic acid-induced seizures in rats.
Topics: Animals; Dapsone; Dose-Response Relationship, Drug; Electroencephalography; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Stereotyped Behavior | 1994 |
Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats.
Topics: Animals; Behavior, Animal; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Sclerosis; Seizures | 1994 |
Blockade of nitric oxide synthesis inhibits hippocampal hyperemia in kainic acid-induced seizures.
Topics: Animals; Arginine; Behavior, Animal; Body Temperature; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Hippocampus; Hyperemia; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Seizures | 1994 |
Expression of GAP-43 in the granule cells of rat hippocampus after seizure-induced sprouting of mossy fibres: in situ hybridization and immunocytochemical studies.
Topics: Animals; GAP-43 Protein; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Membrane Glycoproteins; Nerve Fibers; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reference Values; Seizures; Time Factors | 1994 |
Protective effect of glutathione on kainic acid-induced neuropathological changes in the rat brain.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases; Glucose; Glutathione; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Water | 1994 |
Hypoxia protects against the neurotoxicity of kainic acid.
Topics: Animals; Behavior, Animal; Cell Death; Cerebral Cortex; Hippocampus; Hypoxia; Kainic Acid; Male; Nerve Fibers; Nervous System Diseases; Rats; Rats, Wistar; Seizures; Zinc | 1994 |
p53 induction is associated with neuronal damage in the central nervous system.
Topics: Animals; Apoptosis; Biomarkers; Brain; Cycloheximide; DNA Damage; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neurons; Pyramidal Cells; Rats; Seizures; Tissue Distribution; Tumor Suppressor Protein p53 | 1994 |
Seizures-evoked activation of transcription factors.
Topics: Animals; Brain; DNA; Kainic Acid; Pentylenetetrazole; Protein Binding; Proto-Oncogene Proteins c-jun; Rats; Seizures; Transcription Factors | 1994 |
Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation.
Topics: Animals; Base Sequence; Dizocilpine Maleate; Dopamine; Female; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Kainic Acid; Male; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1994 |
The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoles; Brain; Choline O-Acetyltransferase; Cyclooxygenase Inhibitors; Glutamate Decarboxylase; Ibuprofen; Indomethacin; Isoindoles; Kainic Acid; Lipoxygenase Inhibitors; Male; Organ Specificity; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Mineralocorticoid receptors mediate the enhancing effects of corticosterone on convulsion susceptibility in mice.
Topics: Animals; Corticosterone; Disease Susceptibility; Kainic Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Receptors, Mineralocorticoid; Seizures; Strychnine | 1994 |
Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Brain; Cerebral Cortex; Epilepsy; Fibroblast Growth Factor 2; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Reference Values; Seizures; Time Factors | 1994 |
Phenobarbital modifies seizure-related brain injury in the developing brain.
Topics: Aging; Analysis of Variance; Animals; Brain Diseases; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 1994 |
Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain.
Topics: Acetylation; Acetyltransferases; Animals; Biogenic Polyamines; Brain; Brain Chemistry; Kainic Acid; Male; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Rats; Rats, Sprague-Dawley; Seizures; Spermidine; Spermine | 1994 |
High induction threshold for transcription factor KROX-20 in the rat brain: partial co-expression with heat shock protein 70 following limbic seizures.
Topics: Animals; Brain; DNA-Binding Proteins; Early Growth Response Protein 2; Gene Expression; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Male; Neurons; Organ Specificity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Transcription Factors; Zinc Fingers | 1994 |
Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid.
Topics: Aging; Analysis of Variance; Animals; Brain; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Neurons; Neurotoxins; Pregnancy; Pyramidal Tracts; Receptors, Kainic Acid; Seizures | 1993 |
Kainic acid-induced seizures and brain damage in the rat: different effects of NMDA- and AMPA receptor antagonists.
Topics: Animals; Behavior, Animal; Brain; Dizocilpine Maleate; Drug Synergism; Kainic Acid; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Survival Rate | 1993 |
Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Arousal; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Handling, Psychological; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Propagation of hippocampal seizure activity arising from the hippocampus: a local cerebral blood flow study.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Cerebrovascular Circulation; Electroencephalography; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Kainic acid and 4-aminopyridine seizure models in mice: evaluation of efficacy of anti-epileptic agents and calcium antagonists.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium Channel Blockers; Dizocilpine Maleate; Ion Channel Gating; Kainic Acid; Male; Mice; Seizures | 1994 |
Experimental seizures in the frog (Rana pipiens).
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Cisplatin; Convulsants; Electroencephalography; Kainic Acid; Pentylenetetrazole; Rana pipiens; Seizures; Strychnine | 1994 |
Short- and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection.
Topics: Animals; Brain; Fibroblast Growth Factor 2; Gene Expression; Glial Fibrillary Acidic Protein; In Situ Hybridization; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors | 1994 |
Effects of kainate-induced seizures on cerebral metabolism: a combined 1H and 31P NMR study in rat.
Topics: Acidosis; Adenosine Triphosphate; Animals; Blood Pressure; Brain; Carbon Dioxide; Energy Metabolism; Fourier Analysis; Glycolysis; Homeostasis; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Lactates; Magnetic Resonance Spectroscopy; Oxygen; Partial Pressure; Phosphocreatine; Phosphorus; Rats; Seizures; Time Factors | 1994 |
Suppression of domoic acid induced seizures by 8-(OH)-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Fourier Analysis; Kainic Acid; Male; Microinjections; Neuromuscular Depolarizing Agents; Rats; Rats, Sprague-Dawley; Seizures; Spiro Compounds | 1993 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; Dominance, Cerebral; Dose-Response Relationship, Drug; Drug Combinations; Epilepsy, Temporal Lobe; Ether; Hippocampus; Injections; Injections, Intraperitoneal; Kainic Acid; Magnesium Sulfate; Male; Necrosis; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Neurons; Pentobarbital; Pyramidal Cells; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Seizures | 1993 |
Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization.
Topics: Animals; Chickens; Ciliary Neurotrophic Factor; Ganglia, Parasympathetic; Ganglia, Spinal; Hippocampus; Histocytochemistry; Kainic Acid; Male; Nerve Fibers; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Synapses | 1993 |
cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain.
Topics: Animals; Base Sequence; Blotting, Northern; Brain; Brain Chemistry; DNA, Complementary; Gene Expression; Heat-Shock Proteins; Humans; Ischemic Attack, Transient; Kainic Acid; Molecular Sequence Data; Polymerase Chain Reaction; Rats; RNA, Messenger; Seizures; Sequence Homology, Amino Acid; Stress, Physiological | 1993 |
Experimental seizure-induced brain damage: electrophysiological, metabolic and pathological correlation.
Topics: Amygdala; Animals; Autoradiography; Blood Glucose; Blood-Brain Barrier; Brain Damage, Chronic; Brain Mapping; Calcium; Cats; Dominance, Cerebral; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Limbic System; Rats; Receptors, GABA-A; Seizures | 1993 |
Changes of extracellular GABA concentrations in the ventral hippocampus during kainate-induced seizures in rats.
Topics: Animals; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Microdialysis; Neural Inhibition; Rats; Rats, Wistar; Seizures; Synaptic Transmission | 1993 |
Kainic acid seizures cause enhanced expression of cholecystokinin-octapeptide in the cortex and hippocampus of the rat.
Topics: Amygdala; Animals; Cerebral Cortex; Gene Expression; Hippocampus; Immunoenzyme Techniques; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Neurons; Parietal Lobe; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sincalide | 1993 |
Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia.
Topics: Animals; Base Sequence; Brain; Brain Ischemia; Carrier Proteins; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Kainic Acid; Male; Molecular Chaperones; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors | 1993 |
Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage.
Topics: Animals; Double-Blind Method; Fibroblast Growth Factor 2; Hippocampus; Infusion Pumps, Implantable; Kainic Acid; Male; Neurons; Pilot Projects; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Cell Death; Cycloheximide; Gene Expression; Genes, fos; In Situ Hybridization; Kainic Acid; Male; Neurons; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1993 |
Ontogeny of kainate-induced gene expression in rat hippocampus.
Topics: Animals; Animals, Newborn; Base Sequence; DNA-Binding Proteins; Endorphins; Gene Expression; Hippocampus; Kainic Acid; Male; Molecular Probes; Molecular Sequence Data; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred F344; RNA, Messenger; Seizures; Transcription Factors | 1994 |
Changes in neurofilament protein NF-L and NF-H immunoreactivity following kainic acid-induced seizures.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Male; Neurofilament Proteins; Osmolar Concentration; Phosphorylation; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Seizures | 1994 |
Effect of temperature on kainic acid-induced seizures.
Topics: Animals; Body Temperature; Brain Damage, Chronic; Electroencephalography; Hippocampus; Hyperthermia, Induced; Hypothermia, Induced; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1993 |
Fast and widespread increase of basic fibroblast growth factor messenger RNA and protein in the forebrain after kainate-induced seizures.
Topics: Animals; Fibroblast Growth Factors; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1993 |
Kainic acid seizures in the rat: differential expression of chromogranin A, carboxypeptidase H and peptidylglycine alpha-amidating monooxigenase in subfields of the hippocampal formation.
Topics: Animals; Autoradiography; Carboxypeptidase H; Carboxypeptidases; Chromogranin A; Chromogranins; Gene Expression; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Mixed Function Oxygenases; Multienzyme Complexes; Neurotoxins; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1993 |
Regional and temporal variations in the accumulation of unesterified fatty acids and diacylglycerols in the rat brain during kainic acid induced limbic seizures.
Topics: Animals; Brain; Chromatography, Gas; Diglycerides; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Kainic Acid; Limbic System; Male; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 1993 |
Chronic ethanol intoxication induces differential effects on GABAA and NMDA receptor function in the rat brain.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Convulsants; Dizocilpine Maleate; Ethanol; Isoniazid; Kainic Acid; Male; Membrane Proteins; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Synaptic Transmission | 1993 |
Transcriptional activation of ornithine decarboxylase in adult and neonatal hippocampal slices.
Topics: Aging; Animals; Animals, Newborn; Asparagine; Blotting, Northern; Dactinomycin; Enzyme Activation; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Ornithine Decarboxylase; Polyamines; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Transcription, Genetic | 1993 |
Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of alpha-tubulin.
Topics: Amygdala; Animals; Epilepsy; Hippocampus; Kainic Acid; Limbic System; Male; Nerve Fibers; Rats; Rats, Wistar; RNA, Messenger; Seizures; Time Factors; Tubulin | 1993 |
Kainate-induced changes in opioid peptide genes and AP-1 protein expression in the rat hippocampus.
Topics: Animals; Anticonvulsants; Base Sequence; DNA; Dose-Response Relationship, Drug; Electroencephalography; Endorphins; Gene Expression Regulation; Genes; Hippocampus; Kainic Acid; Male; Molecular Probes; Molecular Sequence Data; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred F344; Seizures; Transcription Factors | 1993 |
L-arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex.
Topics: Animals; Arginine; Brain; Drug Synergism; Electroencephalography; Kainic Acid; Male; Microinjections; N-Methylaspartate; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Seizures; Stereoisomerism | 1993 |
MK801 pretreatment reduces kainic acid-induced spontaneous seizures in prepubescent rats.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Electroencephalography; Epilepsy, Tonic-Clonic; Flurothyl; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1993 |
Influence of ZnCl2 pretreatment on behavioral and histological responses to kainic acid in rats.
Topics: Animals; Chlorides; Drug Administration Schedule; Hippocampus; Kainic Acid; Male; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior; Time Factors; Zinc; Zinc Compounds | 1993 |
High-dose ketamine does not induce c-Fos protein expression in rat hippocampus.
Topics: Amygdala; Animals; Behavior, Animal; Cerebral Cortex; Hippocampus; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Ketamine; Male; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Thalamus | 1993 |
TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration.
Topics: Afferent Pathways; Animals; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Limbic System; Macrophages; Male; Mesoderm; Nerve Degeneration; Rats; Rats, Inbred F344; RNA, Messenger; Seizures; Temporal Lobe; Transforming Growth Factor beta | 1993 |
Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants.
Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Drug Administration Routes; Isoxazoles; Kainic Acid; Male; Mice; N-Methylaspartate; Propionates; Receptors, Glutamate; Seizures | 1993 |
Seizure activity causes a rapid increase in sulfated glycoprotein-2 messenger RNA in the adult but not the neonatal rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Clusterin; Glycoproteins; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Molecular Chaperones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1993 |
Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility.
Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Behavior, Animal; Disease Susceptibility; Electric Stimulation; Flurothyl; Handling, Psychological; Kainic Acid; Kindling, Neurologic; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
Effect of nootropic Solcoseryl on kainic acid-induced excitotoxic brain injury.
Topics: Actihaemyl; Animals; Behavior, Animal; Brain; Brain Chemistry; Glucose; Kainic Acid; Male; Motor Activity; Pons; Psychotropic Drugs; Rats; Rats, Wistar; Reticular Formation; Seizures | 1993 |
Seizures increase trkC mRNA expression in the dentate gyrus of rat hippocampus. Role of glutamate receptor activation.
Topics: Animals; Behavior, Animal; Bicuculline; Cells, Cultured; Dentate Gyrus; Excitatory Amino Acid Agonists; Fetus; GABA-A Receptor Antagonists; Gene Expression; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, trkC; Receptors, Nerve Growth Factor; Ribonucleases; RNA, Messenger; Seizures | 1995 |
Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.
Topics: Aging; Animals; Brain Diseases; Excitatory Amino Acids; Inositol Phosphates; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1995 |
Phosphorylated and non-phosphorylated neurofilament proteins: distribution in the rat hippocampus and early changes after kainic acid induced seizures.
Topics: Animals; Antibodies, Monoclonal; Excitatory Amino Acid Agonists; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Male; Neurofilament Proteins; Neuronal Plasticity; Phosphorylation; Plastic Embedding; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Tissue Fixation | 1995 |
Nicotine blocks kainic acid-induced wet dog shakes in rats.
Topics: Animals; Kainic Acid; Male; Nicotine; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
Systemic administration of kainate induces marked increases of endogenous kynurenic acid in various brain regions and plasma of rats.
Topics: Animals; Anticonvulsants; Brain; Excitatory Amino Acid Agonists; Female; Kainic Acid; Kynurenic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
In vivo microdialysis monitoring for extracellular glutamate and GABA in the ventral hippocampus of the awake rat during kainate-induced seizures.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Microdialysis; Rats; Rats, Wistar; Seizures | 1995 |
Increase in activin beta A mRNA in rat hippocampus during long-term potentiation.
Topics: Activins; Animals; Base Sequence; Convulsants; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Inhibins; Kainic Acid; Long-Term Potentiation; Male; Molecular Sequence Data; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures | 1996 |
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Behavior, Animal; Brain; Brain Diseases, Metabolic; Endopeptidases; Excitatory Amino Acid Agonists; Hyperkinesis; Kainic Acid; Mice; Mice, Transgenic; Mutation; N-Methylaspartate; Neurons; Protein Processing, Post-Translational; Seizures | 1996 |
Limbic seizures originating in the olfactory bulb: an electro-behavioral and glucose metabolism study.
Topics: Animals; Autoradiography; Deoxyglucose; Electroencephalography; Glucose; Kainic Acid; Limbic System; Male; Microinjections; Neurotoxins; Olfactory Bulb; Rats; Rats, Wistar; Seizures | 1995 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Histocytochemistry; Imidazoles; Kainic Acid; Male; Medetomidine; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Seizures; Status Epilepticus; Vigabatrin | 1995 |
Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carboxylic Acids; Cerebral Cortex; Electroshock; Isoquinolines; Kainic Acid; Mice; Models, Molecular; Molecular Structure; Pipecolic Acids; Rats; Receptors, AMPA; Seizures; Stereoisomerism; Structure-Activity Relationship | 1996 |
Nuclear accumulation of p53 protein following kainic acid-induced seizures.
Topics: Animals; Apoptosis; Cell Nucleus; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Tumor Suppressor Protein p53 | 1996 |
Corticotropin-releasing factor induction in rat piriform cortex following kainate-elicited seizures.
Topics: Animals; Corticotropin-Releasing Hormone; Cross Reactions; Immunohistochemistry; Kainic Acid; Male; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; Central Nervous System; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Ethanol; Excitatory Amino Acid Agonists; Kainic Acid; Male; Medicine, African Traditional; Mice; Pentylenetetrazole; Plant Extracts; Plant Leaves; Plants, Medicinal; Poisoning; Rats; Rats, Wistar; Seizures | 1996 |
Kainic acid activates transient expression of tenascin-C in the adult rat hippocampus.
Topics: Animals; Blotting, Western; Hippocampus; Immunohistochemistry; In Situ Hybridization; Interneurons; Kainic Acid; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Tenascin; Time Factors; Transcription, Genetic | 1996 |
Antiepileptic effects of acidic fibroblast growth factor examined in kainic acid-mediated seizures in the rat.
Topics: Analysis of Variance; Animals; Epilepsy; Fibroblast Growth Factors; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Kainic acid-induced seizures enhance dentate gyrus inhibition by downregulation of GABA(B) receptors.
Topics: Animals; Dentate Gyrus; Down-Regulation; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Male; Neural Inhibition; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Seizures; Status Epilepticus; Synaptic Transmission | 1996 |
Studies of Qingyangshen (II): modulatory effect of co-treatment with qingyangshen and diphenylhydantoin sodium on rat hippocampal c-fos expression during seizures.
Topics: Animals; Anticonvulsants; Drugs, Chinese Herbal; Gene Expression Regulation; Genes, fos; Hippocampus; Kainic Acid; Male; Phenytoin; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures | 1996 |
Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain.
Topics: Animals; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Seizures | 1996 |
Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists.
Topics: Alkaloids; Animals; Anticonvulsants; Benzodioxoles; Excitatory Amino Acid Agonists; Female; Injections, Intraventricular; Kainic Acid; Male; Mice; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Seizures; Spinal Cord | 1996 |
Modification of kainate-induced behavioral and electrographic seizures following inhibition of nitric oxide synthase in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Seizures | 1996 |
Factors determining proconvulsant and anticonvulsant effects of inhibitors of nitric oxide synthase in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Kainic Acid; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Species Specificity | 1996 |
Kainic acid-induced focal cortical seizure is associated with an increase of synaptophysin immunoreactivity in the cortex.
Topics: Animals; Cerebral Cortex; Electroencephalography; Immunohistochemistry; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Synaptophysin; Time Factors | 1996 |
Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist.
Topics: Animals; DNA-Binding Proteins; Early Growth Response Protein 1; Electric Stimulation; Enzyme Induction; Hippocampus; Immediate-Early Proteins; Kainic Acid; Male; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Seizures; Transcription Factors; Transcription, Genetic | 1996 |
Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures.
Topics: Animals; Autoradiography; Binding Sites; Hippocampus; Kainic Acid; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Seizures | 1996 |
The effects of dextromethorphan on kainic acid-induced seizures in the rat.
Topics: Animals; Blotting, Western; Dextromethorphan; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred F344; Seizures; Transcription Factor AP-1 | 1996 |
Two synaptotagmin genes, Syt1 and Syt4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures.
Topics: Animals; Animals, Newborn; Brain; Calcium-Binding Proteins; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Seizures; Synaptotagmin I; Synaptotagmins | 1996 |
Plasticity of granule cell-mossy fiber system following kainic acid induced seizures: an immunocytochemical study on neurofilament proteins.
Topics: Animals; Antibodies, Monoclonal; Cell Size; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurofilament Proteins; Neuronal Plasticity; Phosphorylation; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
NG-nitro-L-arginine differentially affects glutamate- or kainate-induced seizures.
Topics: Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nitroarginine; Seizures | 1996 |
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system.
Topics: Animals; Antineoplastic Agents, Phytogenic; Hippocampus; Immunotoxins; Kainic Acid; Male; N-Glycosyl Hydrolases; Plant Proteins; Rats; Rats, Wistar; Ribosome Inactivating Proteins, Type 1; Saporins; Seizures | 1996 |
Seizures induce tenascin-C mRNA expression in neurons.
Topics: Animals; Autoradiography; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Microtubule-Associated Proteins; Neuroglia; Neurons; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Seizures; Tenascin | 1996 |
Stimulation of 5-HT1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Electroencephalography; Hippocampus; Kainic Acid; Male; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Serotonin Antagonists; Serotonin Receptor Agonists | 1996 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; Diazepam; Electroencephalography; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Male; Microdialysis; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Status Epilepticus | 1996 |
Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.
Topics: Animals; Brain; Cerebrovascular Disorders; Kainic Acid; Male; Melatonin; Neuroprotective Agents; Pineal Gland; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Decreased severity of ethanol withdrawal behaviors in kainic acid-treated rats.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Cold Temperature; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1996 |
Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats.
Topics: Animals; Anticonvulsants; Blood Glucose; Convulsants; Drug Evaluation, Preclinical; Glucose; Hypoglycemic Agents; Insulin; Kainic Acid; Male; Ouabain; Penicillins; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Seizures | 1996 |
Chronic seizures increase glucose transporter abundance in rat brain.
Topics: Animals; Brain; Chronic Disease; Glucose Transporter Type 1; Glucose Transporter Type 3; Immunoblotting; Immunohistochemistry; Kainic Acid; Male; Monosaccharide Transport Proteins; Nerve Tissue Proteins; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Reference Values; Seizures; Time Factors | 1996 |
Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate.
Topics: Animals; Cerebrovascular Circulation; Kainic Acid; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase; Parietal Lobe; Rats; Rats, Wistar; Regional Blood Flow; Seizures | 1997 |
Long-term expression of Fos-related antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum.
Topics: Animals; Behavior, Animal; Blotting, Northern; Blotting, Western; Corpus Striatum; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Polymerase Chain Reaction; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred F344; Seizures; Time Factors | 1997 |
Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Isoquinolines; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Tetrazoles | 1996 |
Effects of generalized convulsive seizures on corticotropin-releasing factor neuronal systems.
Topics: Animals; Corticotropin-Releasing Hormone; Gene Expression; Genes, fos; Immunohistochemistry; Kainic Acid; Male; Membrane Potentials; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuropeptides; Protons; Rats; Rats, Sprague-Dawley; Seizures; Temporal Lobe | 1997 |
Basic fibroblast growth factor is highly neuroprotective against seizure-induced long-term behavioural deficits.
Topics: Aging; Animals; Behavior, Animal; Cognition Disorders; Excitatory Amino Acid Agonists; Fibroblast Growth Factor 2; Flurothyl; Handling, Psychological; Kainic Acid; Learning Disabilities; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 1997 |
Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corticotropin-Releasing Hormone; Hippocampus; Kainic Acid; Male; Microinjections; Neurons; Neuroprotective Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Effect of seizures and diuretics on the osmolality of the cerebrospinal fluid.
Topics: Anesthesia; Animals; Cerebrospinal Fluid; Diuretics; Diuretics, Osmotic; Excitatory Amino Acid Agonists; Furosemide; Kainic Acid; Male; Mannitol; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Relationship between GAP-43 expression in the dentate gyrus and synaptic reorganization of hippocampal mossy fibres in rats treated with kainic acid.
Topics: Animals; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GAP-43 Protein; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Membrane Glycoproteins; Nerve Fibers; Nerve Tissue Proteins; Neurofilament Proteins; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Silver Staining; Synapses | 1997 |
Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 1997 |
Oxytocin and vasopressin mRNA expression in rat hypothalamus following kainic acid-induced seizures.
Topics: Animals; Gene Expression; Hypothalamus; Image Processing, Computer-Assisted; In Situ Hybridization; Kainic Acid; Male; Oxytocin; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Supraoptic Nucleus; Up-Regulation; Vasopressins | 1996 |
Effect of pH on domoic acid toxicity in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Kainic Acid; Mice; Mice, Inbred Strains; Neuromuscular Depolarizing Agents; Seizures; Solutions; Time | 1997 |
Increase in mRNAs encoding neonatal II and III sodium channel alpha-isoforms during kainate-induced seizures in adult rat hippocampus.
Topics: Animals; Animals, Newborn; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Genetic Code; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Neuroprotective Agents; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Seizures; Sodium Channels; Transcription, Genetic | 1997 |
Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain.
Topics: Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Kainic Acid; Lithium; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger; Seizures | 1997 |
A new non-NMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Anticonvulsants; Brain; Dizocilpine Maleate; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats.
Topics: Animals; Extracellular Space; Free Radicals; Hippocampus; Kainic Acid; Lipid Metabolism; Male; Rats; Rats, Wistar; Seizures | 1997 |
Acute effects of MK801 on kainic acid-induced seizures in neonatal rats.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Time Factors | 1997 |
Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion' method.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Glutamic Acid; Hippocampus; Kainic Acid; Male; Microdialysis; Rats; Rats, Wistar; Seizures | 1997 |
DNA fragmentation and Prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase.
Topics: Animals; Apoptosis; Brain; Copper; DNA Fragmentation; Excitatory Amino Acid Agonists; Free Radicals; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; HSP70 Heat-Shock Proteins; Humans; Immediate-Early Proteins; In Situ Hybridization; Kainic Acid; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Oxidative Stress; Phagocytosis; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Seizures; Superoxide Dismutase; Superoxides; Zinc | 1997 |
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Desoxycorticosterone; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Isomerism; Kainic Acid; Male; Mice; Muscarinic Agonists; N-Methylaspartate; Pilocarpine; Progesterone; Seizures; Status Epilepticus; Steroids | 1996 |
A novel seizure-induced synaptotagmin gene identified by differential display.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; Calcium-Binding Proteins; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Parietal Lobe; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sequence Homology, Amino Acid; Skates, Fish; Synaptotagmins; Transcription, Genetic | 1997 |
The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine.
Topics: Animals; Behavior, Animal; Brain; Coloring Agents; Electroencephalography; Evans Blue; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Limbic System; Male; Microdialysis; Pilocarpine; Rats; Rats, Wistar; Seizures | 1997 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding Sites; Cerebral Cortex; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Synaptic Membranes; Tritium | 1997 |
Sequelae of parenteral domoic acid administration in rats: comparison of effects on different metabolic markers in brain.
Topics: Animals; Arachidonic Acid; Autoradiography; Biomarkers; Brain; Carbon Radioisotopes; Deoxyglucose; Glial Fibrillary Acidic Protein; Glucose; Infusions, Parenteral; Kainic Acid; Male; Neurotoxins; Organ Specificity; Palmitic Acid; Rats; Rats, Inbred F344; Seizures; Tritium | 1997 |
Seizure-induced alterations of plasma membrane calcium ATPase isoforms 1, 2 and 3 mRNA and protein in rat hippocampus.
Topics: Animals; Calcium-Transporting ATPases; Cell Membrane; Hippocampus; Isoenzymes; Kainic Acid; Male; Nerve Degeneration; Prosencephalon; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Transcription, Genetic | 1997 |
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is differentially induced in neurons and astrocytes after seizures: evidence for developmental, immediate early gene, and lesion response.
Topics: Age Factors; Animals; Antibody Specificity; Astrocytes; Biomarkers; Cell Death; Cycloheximide; Excitatory Amino Acid Agonists; Extracellular Matrix; Gene Expression Regulation, Developmental; Genes, Immediate-Early; Glycoproteins; Hippocampus; Humans; Kainic Acid; Male; Neurons; Protease Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Seizures; Tissue Inhibitor of Metalloproteinases | 1997 |
Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70.
Topics: Adult; Animals; Epilepsy, Temporal Lobe; Hippocampus; HSP70 Heat-Shock Proteins; Humans; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Motor Activity; Rats; Rats, Wistar; Seizures; Stereotyped Behavior | 1997 |
Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amygdala; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Hippocampus; Isoenzymes; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Organ Specificity; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1997 |
Is cell death necessary for hippocampal mossy fiber sprouting?
Topics: Animals; Cell Death; Cerebral Cortex; Dentate Gyrus; DNA Damage; Electric Stimulation; Excitatory Amino Acid Agonists; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; Nerve Fibers; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Effects of pilocarpine and kainate-induced seizures on N-methyl-D-aspartate receptor gene expression in the rat hippocampus.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Hippocampus; Kainic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures | 1997 |
Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid.
Topics: Animals; Dextromethorphan; Enkephalins; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Neurotoxins; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Seizures; Transcription, Genetic | 1997 |
Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection.
Topics: Animals; Antibody Specificity; Cell Count; Cell Death; Denervation; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures; Somatostatin | 1997 |
Seizure-related changes in the glutamate R2 and R5 receptor genes expression in the rat hippocampal formation.
Topics: Animals; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; RNA, Messenger; Seizures | 1997 |
Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kainic Acid; Male; Neuropeptide Y; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Seizures | 1997 |
Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers.
Topics: Animals; Biological Transport, Active; Blotting, Western; Brain-Derived Neurotrophic Factor; Electroshock; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Topics: Aging; Animals; Brain Chemistry; Electroencephalography; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Polarization anatomy of a kainic acid seizure.
Topics: Adjuvants, Anesthesia; Animals; Brain; Electroencephalography; Excitatory Amino Acid Agonists; Fluorescence Polarization; Injections, Intraperitoneal; Kainic Acid; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
A low dose of streptozotocin prevents kainic acid-induced seizures and lethal effects in the rat.
Topics: Animals; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Nitric Oxide; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Streptozocin | 1997 |
Delayed decrease of calbindin immunoreactivity in the granule cell-mossy fibers after kainic acid-induced seizures.
Topics: Animals; Calbindins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley; Recurrence; S100 Calcium Binding Protein G; Seizures | 1997 |
vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Carrier Proteins; Cell Adhesion Molecules; Gene Expression; Gene Expression Regulation; Hippocampus; Homer Scaffolding Proteins; Kainic Acid; Long-Term Potentiation; Male; Microfilament Proteins; Molecular Sequence Data; Neuropeptides; Phosphoproteins; Rats; Rats, Wistar; RNA, Messenger; Seizures; Synapses; Tissue Distribution | 1997 |
GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Humans; Immunohistochemistry; Interneurons; Kainic Acid; Macromolecular Substances; Male; Nerve Degeneration; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Time Factors | 1997 |
Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus.
Topics: Afferent Pathways; Animals; Antibodies, Monoclonal; Cholinergic Agents; Excitatory Amino Acid Agonists; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Immunotoxins; Kainic Acid; Male; N-Glycosyl Hydrolases; Neurons, Afferent; Norepinephrine; Parasympathectomy; Rats; Rats, Wistar; Ribosome Inactivating Proteins, Type 1; Saporins; Seizures; Serotonin; Somatostatin | 1997 |
Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene.
Topics: Animals; Dentate Gyrus; Hippocampus; In Situ Hybridization; Kainic Acid; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; RNA, Complementary; Seizures; Shal Potassium Channels; Time Factors | 1997 |
The relationship between seizures and damage in the maturing brain.
Topics: Age Factors; Amygdala; Animals; Brain; Brain Damage, Chronic; Brain Mapping; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Kindling, Neurologic; Neurons; Rats; Seizures; Status Epilepticus | 1996 |
A new nonNMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Autoradiography; Brain; Deoxyglucose; Excitatory Amino Acid Antagonists; Glucose; Hippocampus; Kainic Acid; Male; Nerve Net; Neuroprotective Agents; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Developmental changes in calpain activity, GluR1 receptors and in the effect of kainic acid treatment in rat brain.
Topics: Animals; Brain; Brain Chemistry; Calpain; Cell Count; Cerebral Cortex; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures; Spectrin | 1997 |
The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons.
Topics: Actins; Animals; Calcium; Calcium Channels; Cells, Cultured; Cytoskeleton; Drug Resistance; Feedback; Gelsolin; Glutamic Acid; Hippocampus; Injections; Ion Transport; Kainic Acid; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Neurotoxins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Stimulation, Chemical | 1997 |
The distribution of beta-amyloid precursor protein in rat cortex after systemic kainate-induced seizures.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain Chemistry; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Microglia; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission | 1997 |
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
Topics: Animals; Apoptosis; Drug Resistance; Excitatory Amino Acid Agonists; Gene Expression; Gene Targeting; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Seizures; Signal Transduction; Transcription Factor AP-1 | 1997 |
Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.
Topics: Action Potentials; Animals; Convulsants; Electroencephalography; Epilepsy; Gene Expression Regulation; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Neuropeptide Y; Perforant Pathway; Seizures; Synaptic Transmission | 1997 |
Changes in the mRNAs encoding subtypes I, II and III sodium channel alpha subunits following kainate-induced seizures in rat brain.
Topics: Animals; Brain; Cerebellar Cortex; Cerebellum; Dentate Gyrus; Digoxigenin; Hippocampus; In Situ Hybridization; Kainic Acid; Medulla Oblongata; Rats; Rats, Wistar; RNA Probes; RNA, Messenger; Seizures; Sodium Channels | 1997 |
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice.
Topics: Animals; Behavior, Animal; Disease Susceptibility; Kainic Acid; Ligands; Mice; Mice, Knockout; Muscarinic Antagonists; Pilocarpine; Receptors, Muscarinic; Seizures | 1997 |
Characterization of the long-lasting activator protein-1 complex induced by kainic acid treatment.
Topics: Animals; Antibody Specificity; Blotting, Western; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Peptide Fragments; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred F344; Seizures; Time Factors; Transcription Factor AP-1 | 1997 |
Selective up-regulation of protein kinase C epsilon in granule cells after kainic acid-induced seizures in rat.
Topics: Amygdala; Animals; Axons; Caudate Nucleus; Dentate Gyrus; Gene Expression Regulation, Enzymologic; Hippocampus; In Situ Hybridization; Isoenzymes; Kainic Acid; Male; Neuroglia; Neurons; Olfactory Bulb; Organ Specificity; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Putamen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors; Transcription, Genetic | 1997 |
Repeated independent exposures to domoic acid do not enhance symptomatic toxicity in outbred or seizure-sensitive inbred mice.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Female; Kainic Acid; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Nervous System Diseases; Neurotoxins; Seizures; Species Specificity | 1997 |
Effects of a subconvulsant dose of kainic acid on afterdischarges elicited by cortical stimulation in rats.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Electroencephalography; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 1997 |
Limbic seizures induce neuropeptide and chromogranin mRNA expression in rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Chromogranin A; Chromogranins; Enkephalins; Epinephrine; Gene Expression Regulation; Kainic Acid; Kinetics; Limbic System; Male; Neuropeptide Y; Norepinephrine; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Thiopental; Transcription, Genetic | 1997 |
Anticonvulsive effect of dapsone: interaction with phenytoin in the kainic acid model of seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Dapsone; Drug Interactions; Injections, Intravenous; Kainic Acid; Phenytoin; Rats; Seizures | 1997 |
BDNF restores the expression of Jun and Fos inducible transcription factors in the rat brain following repetitive electroconvulsive seizures.
Topics: Animals; Body Weight; Brain; Brain-Derived Neurotrophic Factor; Electroshock; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; Seizures; Transcription Factors | 1998 |
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Eye Proteins; Gene Expression; Gene Expression Regulation; Homeodomain Proteins; Kainic Acid; Male; Molecular Sequence Data; Neurons; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA, Messenger; Seizures; Transcription Factors; Xenopus Proteins; Zinc Fingers | 1998 |
The anticonvulsant properties of antisense c-fos oligodeoxynucleotides in kainic acid-induced seizures.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Neuroprotective Agents; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Tissue Fixation | 1997 |
Fos induction following systemic kainic acid: early expression in hippocampus and later widespread expression correlated with seizure.
Topics: Animals; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Hypnotics and Sedatives; Immunohistochemistry; Kainic Acid; Male; Pentobarbital; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Social Isolation | 1997 |
The messenger RNA encoding VGF, a neuronal peptide precursor, is rapidly regulated in the rat central nervous system by neuronal activity, seizure and lesion.
Topics: Animals; Central Nervous System; Cerebral Cortex; Excitatory Amino Acid Antagonists; Eye; Geniculate Bodies; Image Processing, Computer-Assisted; In Situ Hybridization; Injections; Kainic Acid; Male; Neurons; Neuropeptides; Protein Biosynthesis; Proteins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA Probes; RNA, Messenger; Seizures; Tetrodotoxin | 1998 |
[Corticostriatal relations in the waking-sleep cycle of normal rats and in pathology].
Topics: Acoustic Stimulation; Animals; Catalepsy; Caudate Nucleus; Cerebral Cortex; Disease Susceptibility; Dopamine Antagonists; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Sleep; Time Factors; Wakefulness | 1997 |
Endogenous BDNF protein is increased in adult rat hippocampus after a kainic acid induced excitotoxic insult but exogenous BDNF is not neuroprotective.
Topics: Animals; Brain-Derived Neurotrophic Factor; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Kainic Acid; Kinetics; Male; Nerve Growth Factors; Neuroprotective Agents; Neurotoxins; Neurotrophin 3; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, Nerve Growth Factor; RNA, Messenger; Seizures; Time Factors; Transcription, Genetic | 1998 |
Increased corticotropin-releasing factor immunoreactivity in select brain sites following kainate elicited seizures.
Topics: Animals; Brain Chemistry; Brain Mapping; Corticotropin-Releasing Hormone; Immunohistochemistry; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Extracellular levels of neuropeptide Y are markedly increased in the dorsal hippocampus of freely moving rats during kainic acid-induced seizures.
Topics: Animals; Hippocampus; Kainic Acid; Male; Microdialysis; Movement; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures.
Topics: Animals; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; Mice; Mice, Inbred Strains; RNA, Messenger; Seizures | 1998 |
Evidence for Fos involvement in the regulation of proenkephalin and prodynorphin gene expression in the rat hippocampus.
Topics: Animals; Enkephalins; Gene Expression Regulation; Genes, fos; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Oligonucleotides, Antisense; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Transcriptional Activation | 1998 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Melatonin; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Pentylenetetrazole; Quinolinic Acid; Seizures | 1998 |
MRS metabolic markers of seizures and seizure-induced neuronal damage.
Topics: Animals; Aspartic Acid; Biomarkers; Brain; Cell Count; Choline; Creatine; Cycloheximide; Hippocampus; Kainic Acid; Lactates; Magnetic Resonance Spectroscopy; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1998 |
Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures.
Topics: Animals; Behavior, Animal; Cerebrovascular Circulation; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Hyperemia; Kainic Acid; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen Consumption; Rats; Rats, Wistar; Seizures; Status Epilepticus | 1998 |
Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory.
Topics: Animals; Animals, Newborn; Brain; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Kainic Acid; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Seizures; Spatial Behavior | 1997 |
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice.
Topics: Animals; Cell Line; Excitatory Postsynaptic Potentials; Female; GluK2 Kainate Receptor; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Mutagenesis; Neurons; Psychomotor Performance; Receptors, Kainic Acid; Seizures; Synapses | 1998 |
Chlormethiazole anticonvulsive efficacy diminished by N-methyl-D-aspartate but not kainate in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Chlormethiazole; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
Synaptic reorganization following kainic acid-induced seizures during development.
Topics: Aging; Animals; Dentate Gyrus; Excitatory Amino Acid Agonists; GAP-43 Protein; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Synapses | 1998 |
Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting.
Topics: Animals; Behavior, Animal; Cell Count; Excitatory Amino Acid Agonists; Hippocampus; Histocytochemistry; Hypoxia, Brain; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1998 |
Seizures in rats treated with kainic acid induce Fos-like immunoreactivity in locus coeruleus.
Topics: Animals; Dopamine beta-Hydroxylase; Immunohistochemistry; Kainic Acid; Locus Coeruleus; Motor Activity; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Convulsants; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Limbic System; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors | 1998 |
Change in cerebral glucose metabolism during limbic seizures elicited from lateral septal nucleus.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Excitatory Amino Acid Agonists; Glucose; Kainic Acid; Limbic System; Rats; Rats, Wistar; Seizures; Septal Nuclei | 1998 |
Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid.
Topics: Amygdala; Animals; Brain; Cell Death; Chelating Agents; Chlorides; Excitatory Amino Acid Agonists; Hippocampus; Injections; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures; Zinc; Zinc Compounds | 1998 |
mRNA coding for voltage-gated sodium channel beta2 subunit in rat central nervous system: cellular distribution and changes following kainate-induced seizures.
Topics: Animals; Brain; Calcium Channels; Calcium Channels, L-Type; Central Nervous System; Excitatory Amino Acid Agonists; In Situ Hybridization; Ion Channel Gating; Kainic Acid; Kinetics; Male; Rats; Rats, Wistar; RNA, Complementary; RNA, Messenger; Seizures; Spinal Cord | 1998 |
Kainic acid causes redox changes in cerebral cortex extracellular fluid: NMDA receptor activity increases ascorbic acid whereas seizure activity increases uric acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Cerebral Cortex; Excitatory Amino Acid Agonists; Extracellular Space; Kainic Acid; Male; Microdialysis; Midazolam; Oxidation-Reduction; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Uric Acid | 1998 |
Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid.
Topics: Analysis of Variance; Animals; Diazepam; Enzyme Induction; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; In Situ Hybridization; Kainic Acid; Kinetics; Male; Microdialysis; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors; Transcription, Genetic | 1998 |
An immunosuppressant, FK506, protects against neuronal dysfunction and death but has no effect on electrographic and behavioral activities induced by systemic kainate.
Topics: Afferent Pathways; Amygdala; Animals; Brain; Cell Death; Cerebral Cortex; Electroencephalography; Hippocampus; Immunosuppressive Agents; Kainic Acid; Male; Nerve Fibers; Neurons; Rats; Rats, Wistar; Regression Analysis; Seizures; Tacrolimus; Time Factors | 1998 |
Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Female; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Time Factors | 1998 |
The effects of kainic acid in rats with spontaneous recurrent seizures.
Topics: Animals; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 1998 |
Seizure activity induces PIM-1 expression in brain.
Topics: Animals; Brain; Colforsin; Cycloheximide; Female; Gene Expression Regulation; Kainic Acid; Male; Nerve Growth Factors; Organ Specificity; PC12 Cells; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Proto-Oncogenes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sequence Homology, Amino Acid; Transcription, Genetic | 1998 |
Rapid effects of kainate administration on alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor properties in rat hippocampus.
Topics: Analysis of Variance; Animals; Autoradiography; Blotting, Western; Cycloheximide; Hippocampus; Kainic Acid; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Seizures; Subcellular Fractions; Time Factors | 1998 |
Bilateral intranigral NMDA infusion suppresses neuronal injury without affecting the duration of kainic acid-induced seizures in rats.
Topics: Animals; Blood Pressure; Functional Laterality; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Infusions, Parenteral; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra | 1998 |
Effect of a subconvulsant dose of kainic acid on thresholds for phenomena elicited by electrical stimulation of sensorimotor cortex in rats.
Topics: Animals; Electric Stimulation; Excitatory Amino Acid Agonists; Kainic Acid; Male; Motor Cortex; Rats; Rats, Wistar; Seizures; Somatosensory Cortex; Time Factors | 1998 |
Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures.
Topics: Animals; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Seizures | 1998 |
Deficient sensorimotor gating following seizures in amygdala-kindled rats.
Topics: Acoustic Stimulation; Amygdala; Analysis of Variance; Animals; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Inhibition, Psychological; Kainic Acid; Kindling, Neurologic; Pentylenetetrazole; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Seizures | 1998 |
ESR spectroscopy for analysis of hippocampal elimination of a nitroxide radical during kainic acid-induced seizure in rats.
Topics: Animals; Antioxidants; Electron Spin Resonance Spectroscopy; Free Radicals; Hippocampus; Kainic Acid; Male; Nitrogen Oxides; Rats; Rats, Wistar; Seizures | 1998 |
Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain.
Topics: Animals; Brain; Catheterization; Cell Count; Hippocampus; Immunohistochemistry; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Neurons; Neuropeptides; Rats; Rats, Wistar; Receptors, Somatostatin; Seizures | 1998 |
[The effect of hippocampal dentate granule cell lesions upon the limbic seizure model of rats].
Topics: Amygdala; Animals; Colchicine; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Microinjections; Rats; Rats, Wistar; Seizures | 1998 |
Postnatal expression of H1-receptor mRNA in the rat brain: correlation to L-histidine decarboxylase expression and local upregulation in limbic seizures.
Topics: Animals; Animals, Newborn; Brain; Histamine; Histidine Decarboxylase; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Receptors, Histamine H1; RNA, Messenger; Seizures; Tissue Distribution | 1998 |
Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid.
Topics: Animals; Behavior, Animal; Body Temperature; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2; Excitatory Amino Acid Agonists; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; In Situ Hybridization; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Neurons; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1998 |
A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity.
Topics: Animals; Cell Survival; Corpus Striatum; Hippocampus; Kainic Acid; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Substance P; Tachykinins; Time Factors; Transcription, Genetic | 1998 |
Expression of GABA(A) receptor subunits in the hippocampus of the rat after kainic acid-induced seizures.
Topics: Animals; In Situ Hybridization; Kainic Acid; Macromolecular Substances; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Status Epilepticus; Transcription, Genetic | 1998 |
Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat.
Topics: Animals; Cycloheximide; Disease Models, Animal; Electroencephalography; Epilepsy; Evoked Potentials; GAP-43 Protein; Hippocampus; Kainic Acid; Nerve Fibers; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Transcription, Genetic | 1998 |
Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice.
Topics: Animals; Body Weight; Convulsants; Ethanol; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C3H; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome | 1998 |
Regulation of class I MHC gene expression in the developing and mature CNS by neural activity.
Topics: Aging; Animals; Brain; Cats; Cell Communication; Embryonic and Fetal Development; Fetus; Gene Expression Regulation; Gene Expression Regulation, Developmental; Genes, MHC Class I; Histocompatibility Antigens Class I; Kainic Acid; Neurons; Organ Specificity; Polymerase Chain Reaction; Rats; RNA, Messenger; Seizures; Synapses; Tetrodotoxin; Transcription, Genetic | 1998 |
Seizure activity is increased in endocrine states characterized by decline in endogenous levels of the neurosteroid 3 alpha,5 alpha-THP.
Topics: Animals; Brain; Brain Chemistry; Corpus Luteum; Endocrine System; Estrus; Female; Finasteride; Injections, Subcutaneous; Isomerism; Kainic Acid; Postpartum Period; Pregnancy; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Seizures; Time Factors | 1998 |
The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation.
Topics: Aging; Animals; Animals, Newborn; Corticotropin-Releasing Hormone; Differential Threshold; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hormone Antagonists; Kainic Acid; Kindling, Neurologic; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 1998 |
A short episode of seizure activity protects from status epilepticus-induced neuronal damage in rat brain.
Topics: Animals; Brain; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1998 |
[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Electric Stimulation; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pyridines; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile; Strychnine; Time Factors; Weaning | 1999 |
Immunocytochemical evidence for a distinct GFAP-negative subpopulation of astrocytes in the adult rat hippocampus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 1998 |
Heparin-binding epidermal growth factor-like growth factor in hippocampus: modulation of expression by seizures and anti-excitotoxic action.
Topics: Animals; Epidermal Growth Factor; Female; Heparin; Heparin-binding EGF-like Growth Factor; Hippocampus; Intercellular Signaling Peptides and Proteins; Kainic Acid; Male; Nerve Degeneration; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1999 |
Kainic acid may enhance hippocampal NO generation of awake rats in a seizure stage-related fashion.
Topics: Animals; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Extracellular Space; Hippocampus; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Regulated expression of dual specificity protein phosphatases in rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Cell Cycle Proteins; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Dual-Specificity Phosphatases; Immediate-Early Proteins; In Situ Hybridization; Kainic Acid; Male; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; RNA, Messenger; Seizures; Time Factors; Tissue Distribution | 1998 |
Hippocampal and entorhinal cortex high-frequency oscillations (100--500 Hz) in human epileptic brain and in kainic acid--treated rats with chronic seizures.
Topics: Action Potentials; Animals; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electrophysiology; Entorhinal Cortex; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Interneurons; Kainic Acid; Kindling, Neurologic; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
Cyclic withdrawal from endogenous and exogenous progesterone increases kainic acid and perforant pathway induced seizures.
Topics: Animals; Estradiol; Estrus; Female; Kainic Acid; Ovariectomy; Perforant Pathway; Proestrus; Progesterone; Rats; Rats, Long-Evans; Seizures; Substance Withdrawal Syndrome | 1999 |
Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation.
Topics: Animals; Animals, Newborn; Apoptosis; Base Sequence; Cell Division; Excitatory Amino Acid Agonists; Fibroblasts; GABA Antagonists; Gene Expression Regulation, Developmental; Hippocampus; Homozygote; Kainic Acid; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagens; Mutation; Neurons; Pentylenetetrazole; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-jun; Seizures; Stress, Physiological; Ultraviolet Rays | 1999 |
Effect of hypothermia on kainic acid-induced limbic seizures: an electroencephalographic and 14C-deoxyglucose autoradiographic study.
Topics: Amygdala; Animals; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Functional Laterality; Hypothermia; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Seizures | 1999 |
Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus.
Topics: Animals; Atrophy; Catalysis; Fibrinolysin; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neural Cell Adhesion Molecules; Peptide Hydrolases; Seizures; Tissue Plasminogen Activator | 1999 |
Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cell Adhesion Molecules, Neuronal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Energy Metabolism; Epilepsy, Temporal Lobe; Fetal Proteins; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glucose; Hippocampus; Hypertrophy; Injections; Kainic Acid; Male; Mice; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neurons; Protein Isoforms; Sclerosis; Seizures; Silver Staining; Synapses | 1999 |
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Environment; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Nerve Growth Factors; Nerve Tissue Proteins; Phosphorylation; Rats; Rats, Wistar; RNA, Messenger; Seizures | 1999 |
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice.
Topics: Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytarabine; Death; Exons; Homozygote; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Neurons; Proto-Oncogene Proteins c-fos; Seizures | 1998 |
Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Corticosterone; Female; gamma-Aminobutyric Acid; Hippocampus; Immobilization; Kainic Acid; Male; Maze Learning; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Rats; Rats, Long-Evans; Seizures; Sex Characteristics; Stress, Psychological | 1999 |
Limbic seizures increase pronociceptin mRNA levels in the thalamic reticular nucleus.
Topics: Animals; Blotting, Northern; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Seizures; Thalamic Nuclei | 1999 |
Picrotoxin-, kainic acid- and seizure-induced Fos in brainstem, with special reference to catecholamine cell groups.
Topics: Animals; Brain Stem; Gene Expression Regulation; Genes, fos; Kainic Acid; Male; Neurons; Neurotoxins; Organ Specificity; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1999 |
Kainate-elicited seizures induce mRNA encoding a CaMK-related peptide: a putative modulator of kinase activity in rat hippocampus.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cloning, Molecular; Consensus Sequence; DNA, Complementary; Doublecortin Domain Proteins; Doublecortin Protein; Gene Expression Regulation; Hippocampus; Humans; Kainic Acid; Male; Microtubule-Associated Proteins; Molecular Sequence Data; Neuropeptides; Phosphoproteins; Rats; Rats, Wistar; Recombinant Proteins; Seizures; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic | 1999 |
Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cytoprotection; Fibrinolysin; Hippocampus; Humans; Kainic Acid; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Seizures; Tissue Plasminogen Activator; Zinc | 1999 |
Time course of transient expression of GDNF protein in rat granule cells of the bilateral dentate gyri after unilateral intrahippocampal kainic acid injection.
Topics: Animals; Dentate Gyrus; Functional Laterality; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Kainic Acid; Male; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 1999 |
Spontaneous motor seizures of rats with kainate-induced epilepsy: effect of time of day and activity state.
Topics: Animals; Behavior, Animal; Darkness; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Light; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Videotape Recording | 1999 |
Kainic acid (KA)-induced seizures in Sprague-Dawley rats and the effect of dietary taurine (TAU) supplementation or deficiency.
Topics: Amino Acids; Animals; Anticonvulsants; Body Weight; Brain Chemistry; Catecholamines; Diet; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Taurine; Time Factors | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Isoquinolines; Kainic Acid; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pipecolic Acids; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stereoisomerism; Tetrahydroisoquinolines | 1999 |
Immunohistochemical evidence of seizure-induced activation of trk receptors in the mossy fiber pathway of adult rat hippocampus.
Topics: Animals; Cells, Cultured; Electric Stimulation; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Male; Mossy Fibers, Hippocampal; Neural Pathways; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Seizures; Status Epilepticus | 1999 |
Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Genes, jun; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
Autoregressive modeling of the EEG in systemic kainic acid-induced epileptogenesis.
Topics: Animals; Electroencephalography; Epilepsy, Generalized; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Multivariate Analysis; Neocortex; Rats; Seizures | 1999 |
Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model.
Topics: Animals; Dietary Fats; Disease Models, Animal; Kainic Acid; Ketosis; Male; Mossy Fibers, Hippocampal; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Recurrence; Seizures | 1999 |
Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Drug Resistance; Enzyme Activation; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Neurons; Seizures | 1999 |
Responses of heat shock proteins hsp27, alphaB-crystallin, and hsp70 in rat brain after kainic acid-induced seizure activity.
Topics: Animals; Blotting, Northern; Brain; Calbindins; Cerebellum; Crystallins; Entorhinal Cortex; Excitatory Amino Acid Agonists; Female; Heat-Shock Proteins; Hippocampus; HSP70 Heat-Shock Proteins; Kainic Acid; Male; Oxidation-Reduction; Parvalbumins; Rats; Rats, Sprague-Dawley; RNA, Messenger; S100 Calcium Binding Protein G; S100 Proteins; Seizures | 1999 |
Effects of nitric oxide synthase inhibition on the cerebral circulation and brain damage during kainic acid-induced seizures in newborn rabbits.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Cerebral Cortex; Cerebrovascular Circulation; Electroencephalography; Female; Hemoglobins; Hippocampus; Kainic Acid; Laser-Doppler Flowmetry; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxygen; Rabbits; Seizures; Spectroscopy, Near-Infrared | 1999 |
Kainic acid-induced seizure upregulates Na(+)/myo-inositol cotransporter mRNA in rat brain.
Topics: Animals; Brain; Carrier Proteins; Gene Expression Regulation; Heat-Shock Proteins; In Situ Hybridization; Kainic Acid; Kinetics; Male; Membrane Proteins; Neurons; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Symporters; Time Factors; Transcription, Genetic | 1999 |
Differential seizure-induced and developmental changes of neurexin expression.
Topics: Aging; Animals; Animals, Newborn; Gene Expression; Isomerism; Kainic Acid; Male; Nerve Tissue Proteins; Pentylenetetrazole; Rats; Rats, Wistar; RNA Splicing; Seizures | 1999 |
Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain.
Topics: Amygdala; Animals; Base Sequence; Brain; Corpus Striatum; Dentate Gyrus; Frontal Lobe; Gene Expression Regulation; Hypothalamus; Kainic Acid; Male; Molecular Sequence Data; Occipital Lobe; Organ Specificity; Pilocarpine; Protein Precursors; Radioligand Assay; Rats; Rats, Wistar; Receptors, Thyrotropin-Releasing Hormone; RNA, Messenger; Seizures; Thyrotropin-Releasing Hormone; Time Factors; Transcription, Genetic | 1999 |
Anticonvulsant effect of Uncaria rhynchophylla (Miq) Jack. in rats with kainic acid-induced epileptic seizure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Kainic Acid; Lipid Peroxidation; Male; Medicine, Chinese Traditional; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
Kainic acid seizure suppression by neuropeptide Y is not correlated to immediate early gene mRNA levels in rats.
Topics: Animals; Dentate Gyrus; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Hippocampus; Kainic Acid; Male; Neuropeptide Y; Rats; Rats, Wistar; RNA, Messenger; Seizures; Transcription, Genetic; Transcriptional Activation | 1999 |
Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2.
Topics: Animals; Blotting, Northern; Brain; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; DNA-Binding Proteins; Early Growth Response Protein 1; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression; Glutamic Acid; Humans; Immediate-Early Proteins; Isoenzymes; Kainic Acid; Membrane Proteins; Mice; Mice, Transgenic; Neurons; Organ Specificity; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Transcription Factors | 1999 |
Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood.
Topics: Age Distribution; Animals; DNA Fragmentation; Hippocampus; Kainic Acid; Learning; Memory; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 1999 |
Relationship between seizure-induced transcription of the DNA damage-inducible gene GADD45, DNA fragmentation, and neuronal death in focally evoked limbic epilepsy.
Topics: Amygdala; Animals; Brain; Cerebral Cortex; DNA Damage; DNA Fragmentation; Electroencephalography; Epilepsies, Partial; Functional Laterality; GADD45 Proteins; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Limbic System; Male; Microinjections; Neurons; Proteins; Rats; Rats, Sprague-Dawley; Seizures; Thalamus | 1999 |
Generation and analysis of GluR5(Q636R) kainate receptor mutant mice.
Topics: Animals; Behavior, Animal; Electrophysiology; Ganglia, Spinal; Kainic Acid; Mice; Mice, Mutant Strains; Neurons; Pain; Receptors, Kainic Acid; Recombination, Genetic; Reference Values; Seizures | 1999 |
Cell specific expression of Hsp70 in neurons and glia of the rat hippocampus after hyperthermia and kainic acid-induced seizure activity.
Topics: Animals; Blotting, Northern; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Fever; Hippocampus; HSP70 Heat-Shock Proteins; In Situ Hybridization; Kainic Acid; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Vimentin | 1999 |
Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cerebral Cortex; Cloning, Molecular; Excitatory Amino Acid Agonists; Gene Expression Regulation; Genes; Hippocampus; In Situ Hybridization; Interneurons; Kainic Acid; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Neuropeptides; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Seizures; Somatostatin; Transcription Factors; Transcription, Genetic | 1999 |
Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures.
Topics: Animals; Carrier Proteins; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Agonists; In Situ Hybridization; Kainic Acid; Locus Coeruleus; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Neurotransmitter Agents; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Symporters; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1999 |
Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus.
Topics: Animals; Aspirin; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Hippocampus; Indomethacin; Isoenzymes; Kainic Acid; Male; Mice; Neurons; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seizures; Sulfonamides; Time Factors | 1999 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity.
Topics: Animals; Antibodies, Monoclonal; Brain; Brain-Derived Neurotrophic Factor; Female; Gene Expression Regulation; Immunohistochemistry; Kainic Acid; Kinetics; Male; Nerve Growth Factors; Neurotrophin 3; Organ Specificity; Pituitary Gland; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors; Transcription, Genetic | 1999 |
Role of the Y5 neuropeptide Y receptor in limbic seizures.
Topics: Animals; Humans; In Vitro Techniques; Injections, Intraventricular; Kainic Acid; Limbic System; Mice; Mice, Knockout; Receptors, Neuropeptide Y; Seizures | 1999 |
Effects of neonatal seizures on subsequent seizure-induced brain injury.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Convulsants; Disease Susceptibility; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Flurothyl; Kainic Acid; Male; Perforant Pathway; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1999 |
Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures.
Topics: Animals; Cell Death; Dentate Gyrus; Evoked Potentials; Hippocampus; Kainic Acid; Mossy Fibers, Hippocampal; Neurons; Organ Culture Techniques; Pyramidal Cells; Rats; Seizures | 1999 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Mice; Mollusk Venoms; Oocytes; Pentylenetetrazole; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Seizures; Sound; Xenopus | 2000 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; PrPC Proteins; Seizures | 1999 |
Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Fragmentation; Genetic Techniques; In Situ Nick-End Labeling; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Nitrone spin trapping compound N-tert-butyl-alpha-phenylnitrone prevents seizures induced by anticholinesterases.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Behavior, Animal; Brain; Cholinesterase Inhibitors; Cyclic N-Oxides; Excitatory Amino Acid Agonists; Genes, fos; Genes, jun; In Situ Hybridization; Isoflurophate; Kainic Acid; Male; Muscarinic Agonists; Neuroprotective Agents; Nitrogen Oxides; Physostigmine; Pilocarpine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Spin Labels; Spin Trapping | 1999 |
Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fetus; Kainic Acid; Male; Morphine; N-Methylaspartate; Narcotics; Pregnancy; Rats; Seizures | 2000 |
Concentration- and cell type-specific effects of calbindin D28k on vulnerability of hippocampal neurons to seizure-induced injury.
Topics: Animals; Calbindin 1; Calbindins; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; S100 Calcium Binding Protein G; Seizures | 2000 |
Genetic dissection of the signals that induce synaptic reorganization.
Topics: Animals; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; GAP-43 Protein; Gene Expression; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Nerve Degeneration; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Signal Transduction; Species Specificity; Synapses | 2000 |
Induction by synaptic zinc of heat shock protein-70 in hippocampus after kainate seizures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Gene Expression Regulation; Hippocampus; HSP70 Heat-Shock Proteins; Kainic Acid; Kinetics; Male; Mice; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Synapses; Time Factors; Zinc | 2000 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epilepsy, Absence; Frontal Lobe; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoniazid; Kainic Acid; Limbic System; Male; Parietal Lobe; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Strychnine | 2000 |
Kainic acid-induced seizures cause neuronal death in infant rats pretreated with lipopolysaccharide.
Topics: Animals; Animals, Newborn; Cell Survival; Drug Synergism; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Lipopolysaccharides; Mossy Fibers, Hippocampal; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reference Values; Seizures | 2000 |
The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate.
Topics: Amygdala; Animals; Chondroitin Sulfate Proteoglycans; Fibrinolysin; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers; Neurites; Plasminogen; Receptor-Like Protein Tyrosine Phosphatases, Class 5; Seizures; Tissue Plasminogen Activator | 2000 |
Modulatory role of neuropeptides in seizures induced in rats by stimulation of glutamate receptors.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Kainic Acid; Male; Neuropeptide Y; Neuropeptides; Octreotide; Pentylenetetrazole; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neuropeptide Y; Receptors, Somatostatin; Seizures; Somatostatin | 2000 |
Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients.
Topics: Adult; Animals; Antibodies; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Up-Regulation | 2000 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electroshock; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Magnesium Deficiency; Mice; N-Methylaspartate; Patch-Clamp Techniques; Pentylenetetrazole; Phenytoin; Phthalimides; Rats; Seizures; Sodium Channel Blockers; Structure-Activity Relationship; Synaptosomes; Tumor Cells, Cultured | 2000 |
Permanent reduction of seizure threshold in post-ischemic CA3 pyramidal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Patch-Clamp Techniques; Periodicity; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Stimulation, Chemical; Synapses; Time Factors | 2000 |
Seizures and neuronal damage in mice lacking vesicular zinc.
Topics: Animals; Bicuculline; Carrier Proteins; Cation Transport Proteins; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Flurothyl; Genetic Predisposition to Disease; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Metallothionein 3; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Seizures; Synapses; Synaptic Vesicles; Zinc | 2000 |
Reduction of A1 adenosine receptors in rat hippocampus after kainic acid-induced limbic seizures.
Topics: Adenosine; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Somatosensory Cortex | 2000 |
Antiepileptic effect of nefiracetam on kainic acid-induced limbic seizure in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Electrophysiology; Electroshock; Excitatory Amino Acid Agonists; Glucose; Kainic Acid; Limbic System; Male; Pyrrolidinones; Rats; Rats, Wistar; Seizures | 2000 |
Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin.
Topics: Animals; Calbindin 2; Calbindins; Calcium-Binding Proteins; Carrier Proteins; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA Plasma Membrane Transport Proteins; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuropeptide Y; Organic Anion Transporters; Parvalbumins; Receptors, GABA-A; S100 Calcium Binding Protein G; Seizures; Somatostatin | 2000 |
Polyunsaturated fatty acids are potent neuroprotectors.
Topics: alpha-Linolenic Acid; Animals; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Fatty Acids, Unsaturated; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Magnesium; Mice; Mice, Inbred BALB C; Neurons; Palmitic Acid; Potassium Channels; Seizures; Synapsins; Time Factors | 2000 |
Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity.
Topics: Animals; Brain; Cell Nucleus; Drug Resistance; Hindlimb; Hippocampus; Humans; Huntington Disease; Inclusion Bodies; Kainic Acid; Mice; Mice, Transgenic; Mutation; Neurons; Pyramidal Cells; Seizures; Survival Analysis; Time Factors | 2000 |
rTLE3, a newly identified transducin-like enhancer of split, is induced by depolarization in brain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Dentate Gyrus; Electrophysiology; Gene Expression Regulation; Kainic Acid; Male; Molecular Sequence Data; Nuclear Proteins; PC12 Cells; Peptide Fragments; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Tissue Distribution | 2000 |
Estradiol facilitates kainic acid-induced, but not flurothyl-induced, behavioral seizure activity in adult female rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Estradiol; Female; Flurothyl; Hippocampus; Humans; Kainic Acid; Limbic System; Male; Neural Pathways; Progesterone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Cell Death; Chelating Agents; Edetic Acid; Extracellular Space; Fluorescent Dyes; Hippocampus; In Situ Nick-End Labeling; Injections, Intraventricular; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Neurons; Seizures; Zinc | 2000 |
Kainic acid induces distinct types of epileptiform discharge with differential involvement of hippocampus and neocortex.
Topics: Animals; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Neocortex; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Brain distribution and efficacy of carbamazepine in kainic acid induced seizure in rats.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Rats; Seizures; Time Factors | 2000 |
The salt-inducible kinase, SIK, is induced by depolarization in brain.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Colforsin; Cycloheximide; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Genes, Immediate-Early; Hippocampus; Kainic Acid; Membrane Potentials; Molecular Sequence Data; Neurons; PC12 Cells; Phylogeny; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Salts; Seizures; Sequence Homology, Amino Acid; Serine; src-Family Kinases | 2000 |
Magnetic resonance imaging follow-up of progressive hippocampal changes in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Diseases; Disease Models, Animal; Epilepsy, Temporal Lobe; Follow-Up Studies; Functional Laterality; Gadolinium; Hippocampus; Image Enhancement; Kainic Acid; Magnetic Resonance Imaging; Mice; Microinjections; Nerve Degeneration; Sclerosis; Seizures; Status Epilepticus | 2000 |
Experimentally induced attenuation of neuropeptide-Y gene expression in transgenic mice increases mortality rate following seizures.
Topics: Animals; Female; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; Neurons; Neuropeptide Y; RNA, Messenger; Seizures | 2000 |
Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression.
Topics: Animals; Barium; Bicuculline; Cortical Spreading Depression; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Female; GABA Antagonists; Hippocampus; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Male; Microelectrodes; Neuroglia; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Presence of apolipoprotein E immunoreactivity in degenerating neurones of mice is dependent on the severity of kainic acid-induced lesion.
Topics: Animals; Apolipoproteins E; Behavior, Animal; Brain; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurodegenerative Diseases; Neuroglia; Neurons; Neurotoxins; Seizures | 2000 |
Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms.
Topics: Animals; Apoptosis; Dizocilpine Maleate; DNA Fragmentation; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Microscopy, Electron; Necrosis; Neurons; Nucleosomes; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2000 |
Induction of pituitary adenylate cyclase-activating polypeptide mRNA in the medial parvocellular part of the paraventricular nucleus of rats following kainic-acid-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Immunohistochemistry; Kainic Acid; Male; Neuropeptides; Paraventricular Hypothalamic Nucleus; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2000 |
Effects of hypoxia preconditioning on expression of metallothionein-1,2 and heme oxygenase-1 before and after kainic acid-induced seizures.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hippocampus; Hypoxia; Kainic Acid; Male; Metallothionein; Rats; Rats, Wistar; Seizures; Time Factors | 2000 |
Temporal changes in expression of neuronal nitric oxide synthase mRNA in the rat hippocampus associated with kainate-induced seizures.
Topics: Animals; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Kainic Acid; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2000 |
Activin to the rescue for overexcited neurons.
Topics: Activins; Animals; Fibroblast Growth Factor 2; Inhibins; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Seizures; Transforming Growth Factor beta | 2000 |
Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Kainic Acid; Male; Neuronal Plasticity; Pentylenetetrazole; Physical Stimulation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Somatosensory Cortex; Touch; Vibrissae | 2000 |
Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats.
Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; In Vitro Techniques; Kainic Acid; Lysine; Male; Membrane Potentials; Microscopy, Electron; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2000 |
Kainic acid induction of mossy fiber sprouting: dependence on mouse strain.
Topics: Animals; Axons; Hippocampus; Kainic Acid; Kindling, Neurologic; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Mossy Fibers, Hippocampal; Rats; Seizures; Species Specificity | 2000 |
Neuroprotective potential of a viral vector system induced by a neurological insult.
Topics: Animals; Cells, Cultured; Defective Viruses; Genetic Vectors; Glucocorticoids; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Simplexvirus | 2000 |
Propagation of spontaneous synchronized activity in cortical slice cultures recorded by planar electrode arrays.
Topics: Animals; Bicuculline; Cerebral Cortex; Culture Media; Culture Techniques; Electrodes; Kainic Acid; Rats; Seizures | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
The aspirin metabolite sodium salicylate causes focal cerebral hemorrhage and cell death in rats with kainic acid-induced seizures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Death; Cerebral Hemorrhage; Contraindications; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Microglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Sodium Salicylate | 2000 |
Long-term consequences of early postnatal seizures on hippocampal learning and plasticity.
Topics: Age Factors; Animals; Animals, Newborn; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Kainic Acid; Kindling, Neurologic; Long-Term Potentiation; Male; Maze Learning; Memory; Neural Inhibition; Neuronal Plasticity; Rats; Seizures; Space Perception | 2000 |
Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice.
Topics: Animals; Apoptosis; Astrocytes; Caspase 1; Caspase 3; Caspases; DNA, Single-Stranded; Epilepsy; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Granulocyte-Macrophage Colony-Stimulating Factor; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Malondialdehyde; Metallothionein; Metallothionein 3; Mice; Mice, Inbred Strains; Mice, Knockout; Microglia; Nerve Degeneration; Nerve Tissue Proteins; NF-kappa B; Nitrogen; Oxidative Stress; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Seizures; Superoxide Dismutase; Tyrosine; Zinc | 2000 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; Convulsants; Drug Evaluation, Preclinical; Electroshock; Excitatory Amino Acid Agonists; Isoxazoles; Kainic Acid; Mice; Mice, Inbred DBA; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Phthalazines; Propionates; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Structure-Activity Relationship | 2000 |
Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells.
Topics: Animals; Focal Adhesion Kinase 2; Ischemic Attack, Transient; Kainic Acid; Kinetics; Male; Microglia; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Seizures; Signal Transduction; Time Factors | 2000 |
Anticonvulsive effect of swim stress in mice.
Topics: 5-alpha Reductase Inhibitors; Aminoglutethimide; Animals; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Enzyme Inhibitors; Epilepsies, Myoclonic; Excitatory Amino Acid Agonists; Finasteride; Kainic Acid; Ligands; Male; Membranes; Mice; Mice, Inbred CBA; Nerve Tissue Proteins; Prosencephalon; Receptors, GABA-A; Seizures; Stress, Psychological; Swimming | 2000 |
Identification of a negative regulatory DNA element for neuronal BC1 RNA expression by RNA polymerase III.
Topics: Animals; Base Sequence; Brain; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation; Kainic Acid; Male; Mice; Mice, Inbred ICR; Plasmids; Rats; Rats, Wistar; RNA Polymerase III; RNA, Small Cytoplasmic; Seizures; Transcription, Genetic | 2000 |
Substantia nigra pars reticulata lesion facilitates kainic acid-induced seizures.
Topics: Animals; Cardiotonic Agents; Dopamine; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Substantia Nigra | 2000 |
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.
Topics: Animals; Biotin; Blood-Brain Barrier; Brain Injuries; Erythropoietin; Female; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Neuroprotective Agents; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Erythropoietin; Recombinant Proteins; Seizures | 2000 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Drug Design; Humans; Kainic Acid; Male; Mice; Molecular Structure; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Retina; Seizures; Structure-Activity Relationship | 2000 |
Differential regulation of adult and embryonic glutamate decarboxylases in rat dentate granule cells after kainate-induced limbic seizures.
Topics: Animals; Dentate Gyrus; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2000 |
Melatonin attenuates the changes in polyamine levels induced by systemic kainate administration in rat brains.
Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Hippocampus; Kainic Acid; Male; Melatonin; Polyamines; Putrescine; Rats; Rats, Sprague-Dawley; Seizures; Spermidine; Spermine | 2000 |
In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Hippocampus; Image Enhancement; Kainic Acid; Male; Oxidative Stress; Phantoms, Imaging; Pyrrolidines; Rats; Rats, Wistar; Reference Values; Seizures; Sensitivity and Specificity | 2000 |
Magnesium prevents seizure-induced reduction in excitatory amino acid receptor (kainate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) binding in pregnant rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Female; Kainic Acid; Magnesium Sulfate; Pregnancy; Pregnancy, Animal; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Sodium Chloride; Tissue Distribution | 2000 |
Sensory stimulation increases cortical expression of the fragile X mental retardation protein in vivo.
Topics: Animals; Calcineurin; Fragile X Mental Retardation Protein; Fragile X Syndrome; Intellectual Disability; Kainic Acid; Male; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Seizures; Sensory Thresholds; Somatosensory Cortex | 2000 |
Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization.
Topics: Animals; Calmodulin-Binding Proteins; GAP-43 Protein; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Membrane Proteins; Microglia; Mossy Fibers, Hippocampal; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Neurogranin; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Synapses; Vesicular Transport Proteins | 2000 |
Effects of oxcarbazepine on the behavioral response and neuroanatomical alterations following administration of kainic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Nervous System; Oxcarbazepine; Rats; Rats, Wistar; Seizures | 2000 |
Sparing of neuronal function postseizure with gene therapy.
Topics: Animals; Cells, Cultured; Genetic Therapy; Glucose Transporter Type 1; Hippocampus; Humans; Kainic Acid; Monosaccharide Transport Proteins; Neurons; Proto-Oncogene Proteins c-bcl-2; Rats; Seizures; Task Performance and Analysis | 2000 |
Neuroprotective role of dopamine against hippocampal cell death.
Topics: Animals; Autoradiography; Cell Death; Dopamine; Dose-Response Relationship, Drug; Female; Habenula; Heterozygote; Hippocampus; Homozygote; In Situ Nick-End Labeling; Inbreeding; Kainic Acid; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neuroprotective Agents; Receptors, Dopamine D2; Receptors, Glutamate; Seizures | 2000 |
Anticonvulsant action and long-term effects of gabapentin in the immature brain.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Flurothyl; Gabapentin; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Kainic Acid; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley; Seizures; Space Perception | 2001 |
Regional and age-related expression of gelatinases in the brains of young and old rats after treatment with kainic acid.
Topics: Age Factors; Animals; Brain; Cell Death; Excitatory Amino Acid Agonists; Kainic Acid; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pyramidal Cells; Rats; Rats, Inbred F344; Seizures | 2000 |
Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background.
Topics: Animals; Cell Death; Epilepsy; Hippocampus; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Neurotoxins; Phosphorylation; Proto-Oncogene Proteins c-jun; Seizures; Time Factors | 2000 |
Mitochondrial superoxide production in kainate-induced hippocampal damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitate Hydratase; Animals; Cell Death; Deoxyguanosine; DNA Damage; Epilepsy; Free Radical Scavengers; Hippocampus; Kainic Acid; Male; Metalloporphyrins; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase; Superoxides | 2000 |
Regulation of rat hippocampal neural cadherin in the kainic acid induced seizures.
Topics: Animals; Cadherins; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; RNA, Messenger; Seizures | 2001 |
Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors.
Topics: Animals; Female; Hippocampus; Kainic Acid; Learning; Long-Term Potentiation; Male; Memory; Mice; Mice, Knockout; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Seizures | 2000 |
Protective effects of TRH and its stable analogue, RGH-2202, on kainate-induced seizures and neurotoxicity in rodents.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; L-Lactate Dehydrogenase; Male; Mice; Neurons; Neurotoxins; Seizures; Thyrotropin-Releasing Hormone | 2001 |
Timing of ketogenic diet initiation in an experimental epilepsy model.
Topics: Animals; Brain; Diet, Protein-Restricted; Dietary Carbohydrates; Dietary Fats; Excitatory Amino Acid Antagonists; Kainic Acid; Ketosis; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2000 |
Differential changes in neuropeptide Y and nicotinamide adenine dinucleotide phosphate-diaphorase-positive neurons in rat hippocampus after kainic acid-induced seizure.
Topics: Animals; Excitatory Amino Acid Agonists; Hippocampus; Immunoenzyme Techniques; Kainic Acid; Male; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Rats; Rats, Inbred F344; Seizures | 2001 |
Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Carrier Proteins; Chronic Disease; Dose-Response Relationship, Drug; Down-Regulation; Epilepsy; Extracellular Space; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Potassium; Rats; Rats, Wistar; RNA, Messenger; Seizures | 2001 |
Estrogen differentially alters NMDA- and kainate-induced seizures in prenatally morphine- and saline-exposed adult female rats.
Topics: Analgesics, Opioid; Animals; Estradiol; Excitatory Amino Acid Agonists; Female; Kainic Acid; Morphine; N-Methylaspartate; Ovariectomy; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures; Sodium Chloride; Stereotyped Behavior | 2000 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures | 2001 |
Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.
Topics: Animals; Brain; Cerebral Cortex; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Seizures | 2001 |
The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Hippocampus; In Situ Nick-End Labeling; Isoenzymes; Kainic Acid; Lactones; Male; Prostaglandin-Endoperoxide Synthases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sulfones | 2001 |
The role of RNA editing of kainate receptors in synaptic plasticity and seizures.
Topics: Animals; Binding Sites; Calcium; Cells, Cultured; Dentate Gyrus; Female; GluK2 Kainate Receptor; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; Mice; Mice, Mutant Strains; Neuronal Plasticity; Neurons; Perforant Pathway; Receptors, Kainic Acid; RNA Editing; Seizures; Synapses | 2001 |
Effects of dextromethorphan on the seizures induced by kainate and the calcium channel agonist BAY k-8644: comparison with the effects of dextrorphan.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Calcium Channel Agonists; Dextromethorphan; Dextrorphan; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Mice, Inbred DBA; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Transcription Factor AP-1 | 2001 |
Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Gliosis; Hippocampus; In Situ Nick-End Labeling; Interleukin-6; Kainic Acid; Macrophages; Metallothionein; Mice; Mice, Knockout; Microglia; Nerve Degeneration; Oxidative Stress; Seizures; Superoxide Dismutase | 2001 |
Kainate receptors keep the excitement high.
Topics: Animals; Anticonvulsants; Convulsants; gamma-Aminobutyric Acid; Hippocampus; Humans; Kainic Acid; Pyramidal Cells; Receptors, Kainic Acid; Seizures | 2001 |
Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure.
Topics: Animals; Enzyme Activation; Hippocampus; Kainic Acid; Limbic System; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Rats; Seizures | 2000 |
A spontaneous recurrent seizure-related Rattus NSF gene identified by linker capture subtraction.
Topics: Animals; Base Sequence; Blotting, Northern; Carrier Proteins; Cloning, Molecular; Epilepsy; Excitatory Amino Acid Agonists; Genetic Linkage; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; N-Ethylmaleimide-Sensitive Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Vesicular Transport Proteins | 2001 |
Changes in striatal electroencephalography and neurochemistry induced by kainic acid seizures are modified by dopamine receptor antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Benzazepines; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electroencephalography; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Homovanillic Acid; Kainic Acid; Neurochemistry; Receptors, Dopamine D1; Receptors, Dopamine D2; Seizures; Sulpiride | 2001 |
Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities.
Topics: Animals; Cytoskeleton; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; SAP90-PSD95 Associated Proteins; Seizures; Subcellular Fractions; Synaptic Membranes; Tyrosine | 2001 |
Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death.
Topics: Animals; ATP-Binding Cassette Transporters; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cricetinae; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Gene Expression; Kainic Acid; Mice; Mice, Transgenic; Neurons; Potassium Channels; Potassium Channels, Inwardly Rectifying; Promoter Regions, Genetic; Prosencephalon; Receptors, Drug; Recombinant Fusion Proteins; RNA, Messenger; Seizures; Sulfonylurea Receptors | 2001 |
Effects of glutathione depletion by 2-cyclohexen-1-one on excitatory amino acids-induced enhancement of activator protein-1 DNA binding in murine hippocampus.
Topics: Animals; Binding Sites; Cyclohexanones; Excitatory Amino Acids; Glutathione; Hippocampus; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Oligodeoxyribonucleotides; Posture; Seizures; Time Factors; Transcription Factor AP-1; Tremor | 2001 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2001 |
[The microglial activation and the expression of heat shock protein 27 through the propagation pathway of kainic acid-induced hippocampal seizure in the rat].
Topics: Acute Disease; Animals; Biomarkers; Brain; Heat-Shock Proteins; Hippocampus; Kainic Acid; Male; Microglia; Rats; Rats, Sprague-Dawley; Seizures | 2001 |
Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Brain; Carrier Proteins; Electroencephalography; Excitatory Amino Acid Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Transgenic; Neural Inhibition; Neurons; Organic Anion Transporters; Receptors, GABA-A; Seizures; Synaptosomes; Up-Regulation | 2001 |
Kainic acid-induced dorsal and ventral hippocampal seizures in rats.
Topics: Amygdala; Animals; Electroencephalography; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Microinjections; Motor Cortex; Organ Specificity; Rats; Rats, Wistar; Seizures | 2001 |
Caspase-2 activation is redundant during seizure-induced neuronal death.
Topics: Amygdala; Animals; Apoptosis; Brain; Caspase 2; Caspase Inhibitors; Caspases; Cell Nucleus; Cytoplasm; Diazepam; DNA Fragmentation; Electroencephalography; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Microinjections; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2001 |
Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Behavior, Animal; Brain; Cells, Cultured; Disease Susceptibility; Endosomal Sorting Complexes Required for Transport; Female; Fertility; Gene Expression; Gene Targeting; Hippocampus; Interleukin-2; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phenotype; Phosphoproteins; Seizures; Subcellular Fractions; T-Lymphocytes | 2001 |
AIT-082 is neuroprotective against kainate-induced neuronal injury in rats.
Topics: Aminobenzoates; Analysis of Variance; Animals; Cell Survival; Dentate Gyrus; Diazepam; Electroencephalography; Face; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Hypoxanthines; Kainic Acid; Male; Motor Activity; Mouth; Neurons; Neuroprotective Agents; Purines; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Time Factors | 2001 |
Nimesulide aggravates kainic acid-induced seizures in the rat.
Topics: Animals; Behavior, Animal; Blotting, Northern; Cerebral Cortex; Cyclooxygenase Inhibitors; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Hippocampus; In Situ Hybridization; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Sulfonamides; Time Factors | 2001 |
Increased Bcl-w expression following focally evoked limbic seizures in the rat.
Topics: Amygdala; Animals; Blotting, Western; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Microinjections; Neurons; Olfactory Pathways; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Seizures | 2001 |
Estrone, but not 17 beta-estradiol, attenuates kainate-induced seizures and toxicity in male mice.
Topics: Animals; Estradiol; Estrogen Antagonists; Estrone; Hippocampus; Immunity; Kainic Acid; Male; Mice; Neurons; Seizures; Tamoxifen | 2001 |
A comparative neuroethological study of limbic seizures induced by Parawixia bistriata venom and kainic acid injections in rats.
Topics: Animals; Behavior, Animal; Kainic Acid; Limbic System; Male; Neurons; Rats; Rats, Wistar; Receptors, Kainic Acid; Seizures; Software Design; Spider Venoms | 2001 |
Increased expression of Fas (CD95/APO-1) in adult rat brain after kainate-induced seizures.
Topics: Animals; Brain; Cell Death; Excitatory Amino Acid Agonists; fas Receptor; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Tumor Suppressor Protein p53 | 2001 |
Dna fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell death.
Topics: Animals; Apoptosis Regulatory Proteins; Cell Count; Cell Death; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Resistance; Genes, Immediate-Early; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Macromolecular Substances; Mice; Mice, Mutant Strains; Neurons; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Seizures | 2001 |
Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation.
Topics: Animals; Benzoxazines; Brain; Cells, Cultured; Cyclopentanes; Drug Interactions; Immunohistochemistry; Kainic Acid; Male; Oxazines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Seizures; Sigma-1 Receptor | 2001 |
Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
Topics: Animals; Arginine; Astrocytes; Crystallins; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gliosis; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Indazoles; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Molecular Chaperones; Neoplasm Proteins; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Seizures | 2001 |
Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity.
Topics: Action Potentials; Animals; Behavior, Animal; Cell Line; Electric Stimulation; Excitatory Postsynaptic Potentials; Gene Targeting; Genetic Predisposition to Disease; Hippocampus; In Situ Hybridization; In Vitro Techniques; Kainic Acid; Kallikreins; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Serine Endopeptidases; Stem Cells | 2001 |
Topiramate blocks perinatal hypoxia-induced seizures in rat pups.
Topics: Animals; Animals, Suckling; Anticonvulsants; Convulsants; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Fructose; Hippocampus; Hypoxia, Brain; Kainic Acid; Male; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Topiramate | 2001 |
Genetic comparison of seizure control by norepinephrine and neuropeptide Y.
Topics: Animals; Dopamine beta-Hydroxylase; Exercise Test; Flurothyl; Genetic Predisposition to Disease; Handling, Psychological; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Knockout; Neuropeptide Y; Norepinephrine; Pentylenetetrazole; Phenotype; Seizures | 2001 |
Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration.
Topics: Animals; Autoradiography; Brain Chemistry; Caspase 3; Caspases; Cerebral Cortex; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP70 Heat-Shock Proteins; In Situ Hybridization; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Tissue Proteins; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Thalamus; Time Factors | 2001 |
Domoic acid-induced neuronal damage in the rat hippocampus: changes in apoptosis related genes (bcl-2, bax, caspase-3) and microglial response.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Convulsants; Gene Expression Profiling; Gene Expression Regulation; Genes, bcl-2; Hippocampus; Histocompatibility Antigens Class II; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Macrophage-1 Antigen; Male; Marine Toxins; Microglia; Microscopy, Electron; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Phagocytosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Time Factors; Up-Regulation | 2001 |
Seizure activity results in increased tyrosine phosphorylation of the N-methyl-D-aspartate receptor in the hippocampus.
Topics: Animals; Blotting, Western; Detergents; Electrophoresis, Polyacrylamide Gel; Hippocampus; Kainic Acid; Male; Phosphorylation; Precipitin Tests; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Seizures; Solubility; Tyrosine | 2001 |
Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures.
Topics: Aconitate Hydratase; Animals; Cell Count; Cell Death; Cell Survival; Excitatory Amino Acid Agonists; F2-Isoprostanes; Fumarate Hydratase; Hippocampus; Kainic Acid; Lipid Peroxidation; Male; Mitochondria; Rats; Rats, Sprague-Dawley; Seizures; Superoxides | 2001 |
Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease.
Topics: Animals; Cerebral Hemorrhage; Excitatory Amino Acid Agonists; Gene Expression Profiling; Genetic Markers; Glucose; Humans; Hypoglycemia; Hypoxia; Insulin; Kainic Acid; Leukocytes; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Stroke | 2001 |
[Ability of novel non-competitive glutamate receptor blocking agents to weaken motor disorders in animals].
Topics: Animals; Anticonvulsants; Ataxia; Benzene Derivatives; Catalepsy; Cations; Cyclohexanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Mice; N-Methylaspartate; Parkinsonian Disorders; Seizures; Structure-Activity Relationship | 2001 |
Regional accumulation of 14C-zonisamide in rat brain during kainic acid-induced limbic seizures.
Topics: Animals; Anticonvulsants; Carbon Radioisotopes; Excitatory Amino Acid Agonists; Injections, Intraventricular; Isoxazoles; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Seizures; Zonisamide | 2001 |
Effect of oxcarbazepine on kainic acid-induced seizure.
Topics: Animals; Anticonvulsants; Carbamazepine; Electrodes, Implanted; Electroencephalography; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Oxcarbazepine; Rats; Rats, Wistar; Seizures | 2001 |
Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling.
Topics: Aging; Animals; Animals, Newborn; Cell Count; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Male; Mossy Fibers, Hippocampal; Neural Inhibition; Neuronal Plasticity; Neurons; Perforant Pathway; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2001 |
Matrix metalloproteinase-9 undergoes expression and activation during dendritic remodeling in adult hippocampus.
Topics: Animals; Dendrites; Enzyme Activation; Excitatory Amino Acid Agonists; Extracellular Matrix; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuronal Plasticity; Neurons; Organ Specificity; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2002 |
Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment.
Topics: Aging; Animals; Brain Chemistry; Cell Count; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Lipid Peroxidation; Lipofuscin; Malondialdehyde; Mice; Mice, Inbred Strains; Microscopy, Electron; Nerve Tissue Proteins; Neurotoxicity Syndromes; Oxidative Stress; Seizures | 2002 |
Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Free Radical Scavengers; Hydroxyl Radical; Kainic Acid; Lipid Peroxidation; Male; Melatonin; Mice; Seizures | 2002 |
Comparative study of the epileptogenic effect of kainic acid injected into the cerebral cortex, hippocampus and amygdala in adult cats chronically implanted.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Cats; Cerebral Cortex; Electroencephalography; Electrophysiology; Excitatory Amino Acid Antagonists; Female; GABA Agonists; Hippocampus; Kainic Acid; Male; Microinjections; Muscimol; Seizures | 2002 |
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice.
Topics: Administration, Intranasal; Age Factors; Animals; Apoptosis; Behavior, Animal; Body Weight; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Isoenzymes; Kainic Acid; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Prostaglandin-Endoperoxide Synthases; Seizures; Survival Rate | 2002 |
PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain.
Topics: Animals; Behavior, Animal; Binding, Competitive; Blotting, Western; Hippocampus; Hyperkinesis; Isoquinolines; Kainic Acid; Ligands; Male; Prosencephalon; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2002 |
Nitric oxide donor increases cerebral blood flow and oxygenation during kainic acid-induced seizures in newborn rabbits.
Topics: Animals; Animals, Newborn; Brain; Cerebrovascular Circulation; Electroencephalography; Female; Hemodynamics; Kainic Acid; Models, Animal; Nitric Oxide Donors; Nitroprusside; Rabbits; Regional Blood Flow; Seizures | 2002 |
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Agonists; Glycoproteins; Hippocampus; Kainic Acid; Limbic System; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptides; Neuroserpin; Neurotoxins; Plasminogen; Plasminogen Activators; Rats; Rats, Sprague-Dawley; Seizures; Serine Proteinase Inhibitors; Serpins; Tissue Plasminogen Activator | 2002 |
Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision.
Topics: Animals; Astrocytes; Blotting, Western; Brain Injuries; Chondroitin Sulfate Proteoglycans; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Lectins, C-Type; Membrane Glycoproteins; Membrane Proteins; Nerve Tissue Proteins; Neurocan; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptor-Like Protein Tyrosine Phosphatases, Class 5; RNA, Messenger; Seizures; Syndecan-3; Time Factors | 2002 |
[Epileptogenic action of intra-amygdaloid injection of kainic acid].
Topics: Amygdala; Animals; Diazepam; Disease Models, Animal; Hippocampus; Injections; Kainic Acid; Male; Pyrrolidines; Rats; Seizures; Status Epilepticus | 1978 |
[Primary and secondary cerebral lesions produced by kainic acid injections in the rat].
Topics: Amygdala; Animals; Brain Diseases; Hippocampus; Injections; Kainic Acid; Pyrrolidines; Rats; Seizures; Thalamic Nuclei | 1979 |
Evidence suggesting secondary epileptogenic lesion after kainic acid: pre treatment with diazepam reduces distant but not local brain damage.
Topics: Amygdala; Animals; Diazepam; Hippocampus; Kainic Acid; Nerve Degeneration; Neural Pathways; Premedication; Pyrrolidines; Rats; Seizures | 1979 |
A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Kainic Acid; Male; Models, Neurological; Nerve Degeneration; Pyrrolidines; Rats; Seizures; Status Epilepticus | 1979 |
Effects of morphine or naloxone on kainic acid neurotoxicity.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Kainic Acid; Male; Morphine; Naloxone; Pyrrolidines; Rats; Seizures | 1979 |
Glutamic acid and ethanol dependence.
Topics: Alcoholism; Animals; Brain Chemistry; Ethanol; Excitatory Amino Acid Antagonists; Glutamates; Humans; Kainic Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Substance Withdrawal Syndrome; Time Factors | 1978 |
Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells.
Topics: Animals; Glutamates; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Pyramidal Tracts; Pyrrolidines; Rats; Receptors, Drug; Seizures | 1978 |
Limbic seizures cause pronounced changes in the expression of neurokinin B in the hippocampus of the rat.
Topics: Animals; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Male; Neurokinin B; Nucleic Acid Hybridization; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Substance P; Tachykinins | 1992 |
Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; Pentobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Trypsin Inhibitor, Kunitz Soybean | 1992 |
Antagonism of kainic acid lesions in the mouse hippocampus by U-54494A and U-50488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Image Processing, Computer-Assisted; Injections, Intraventricular; Kainic Acid; Male; Mice; Neuroglia; Neurons; Pyrrolidines; Receptors, Opioid; Seizures; Vacuoles | 1992 |
Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain.
Topics: Animals; Benzodiazepinones; Biogenic Polyamines; Brain; Brain Chemistry; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Female; Hippocampus; Kainic Acid; Neurons; Ornithine Decarboxylase; Pregnancy; Putrescine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Spectrin | 1992 |
Differential regulation of the nerve growth factor and brain-derived neurotrophic factor genes in L929 mouse fibroblasts.
Topics: Animals; Base Sequence; Blotting, Northern; Brain-Derived Neurotrophic Factor; Colforsin; Corticosterone; Cyclic AMP; Fibroblasts; Gene Expression Regulation; Hippocampus; Kainic Acid; L Cells; Male; Mice; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Tetradecanoylphorbol Acetate | 1992 |
Seizure circuit analysis with voltage sensitive dye.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Brain; Brain Mapping; Disease Models, Animal; Fluorescent Dyes; Kainic Acid; Limbic System; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat.
Topics: Animals; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Neurons; Neuropeptide Y; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Somatostatin | 1992 |
Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain Mapping; Chromatography, High Pressure Liquid; Dialysis; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Seizures; Serine; Synaptic Transmission | 1992 |
Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Glycoproteins; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neuronal Plasticity; Phospholipases A; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Section of the corpus callosum in kainic acid induced seizures in rats: behavioral, electroencephalographic and neuropathological study.
Topics: Animals; Behavior, Animal; Corpus Callosum; Electroencephalography; Hippocampus; Kainic Acid; Limbic System; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1992 |
Comparison of regional blood-brain transport kinetics between glucose and fluorodeoxyglucose.
Topics: Animals; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Deoxyglucose; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Image Processing, Computer-Assisted; Kainic Acid; Radionuclide Imaging; Rats; Seizures | 1992 |
[Kainic acid-induced generalized seizures in cats--microinjection into caudate nucleus].
Topics: Animals; Behavior, Animal; Cats; Caudate Nucleus; Electroencephalography; Epilepsies, Partial; Injections; Kainic Acid; Seizures | 1992 |
Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital.
Topics: Animals; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Nerve Degeneration; Nerve Fibers; Phenobarbital; Rats; Rats, Sprague-Dawley; Seizures; Synapses; Time Factors | 1992 |
The prodynorphin system in the rat hippocampus is differentially influenced by kainic acid and pentetrazole.
Topics: Animals; Autoradiography; Enkephalins; Hippocampus; In Situ Hybridization; In Vitro Techniques; Kainic Acid; Male; Pentylenetetrazole; Protein Precursors; Rats; Rats, Wistar; Reference Values; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1992 |
In vivo mapping of drug-induced seizures with voltage-sensitive dye.
Topics: Animals; Autoradiography; Bicuculline; Blood Pressure; Brain; Brain Mapping; Coloring Agents; Deoxyglucose; Electric Stimulation; Kainic Acid; Male; Membrane Potentials; Models, Neurological; Neural Pathways; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Feeding disturbances and EEG activity changes after amygdaloid kainate lesions in the rat.
Topics: Amygdala; Analysis of Variance; Animals; Body Weight; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Feeding Behavior; Hippocampus; Iontophoresis; Kainic Acid; Male; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1992 |
Persistent hyperexcitability in isolated hippocampal CA1 of kainate-lesioned rats.
Topics: Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Evoked Potentials; Hippocampus; In Vitro Techniques; Injections; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Kainic acid-induced thalamic seizure in cats--a possible model of petit mal seizure.
Topics: Animals; Cats; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; Kainic Acid; Male; Seizures; Stereotaxic Techniques; Thalamic Nuclei; Thalamus | 1992 |
Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus.
Topics: Amino Acids; Animals; Extracellular Space; Glucocorticoids; Hippocampus; Kainic Acid; Male; Mannose; Osmolar Concentration; Rats; Rats, Inbred Strains; Seizures | 1992 |
Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures.
Topics: Aging; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Electrodes; Electroencephalography; Flurothyl; Kainic Acid; Male; Myoclonus; Rats; Rats, Inbred Strains; Recurrence; Seizures; Status Epilepticus | 1992 |
Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Injections, Intraventricular; Kainic Acid; Male; Mice; Myoclonus; N-Methylaspartate; Quisqualic Acid; Seizures; Status Epilepticus | 1992 |
Changes in polyamine levels and spectrin degradation following kainate-induced seizure activity: effect of difluoromethylornithine.
Topics: Animals; Eflornithine; Hippocampus; Kainic Acid; Male; Polyamines; Rats; Seizures; Spectrin | 1992 |
BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity.
Topics: Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Hippocampus; Kainic Acid; Nerve Growth Factors; Nerve Tissue Proteins; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures | 1992 |
The anticonvulsant effects of vitamin E: a further evaluation.
Topics: Animals; Anticonvulsants; Electrophysiology; Electroshock; Epilepsy, Complex Partial; Ferrous Compounds; Hyperbaric Oxygenation; Kainic Acid; Kindling, Neurologic; Male; Penicillins; Rats; Seizures; Vitamin E | 1992 |
Absence of c-fos induction in neonatal rat brain after seizures.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain Chemistry; Cerebral Cortex; Disease Susceptibility; Gene Expression Regulation; Genes, fos; Hippocampus; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Seizures; Transcription, Genetic | 1992 |
Blood-brain barrier dysfunctions following systemic injection of kainic acid in the rat.
Topics: Aminoisobutyric Acids; Animals; Blood-Brain Barrier; Brain; Glucose; Injections, Intravenous; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1992 |
Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid.
Topics: Animals; Blotting, Northern; Brain; Brain-Derived Neurotrophic Factor; Female; Hippocampus; Histocytochemistry; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Nucleic Acid Hybridization; Pentobarbital; Rats; Rats, Inbred Strains; RNA Probes; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1992 |
Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models.
Topics: Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Isoniazid; Kainic Acid; Male; Microinjections; Muscimol; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Substantia Nigra; Synaptic Transmission | 1991 |
Dipeptides--analogues of N-acetylaspartylglutamate inhibit convulsive effects of excitatory amino acids in mice.
Topics: Animals; Cerebral Ventricles; Dipeptides; Glutamates; Glutamic Acid; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurotoxins; Pentylenetetrazole; Seizures; Structure-Activity Relationship | 1991 |
Anticonvulsant effect of striatal dopamine D2 receptor stimulation: dependence on cortical circuits?
Topics: Animals; Anticonvulsants; Cerebral Cortex; Corpus Striatum; Dopamine Agents; Ergolines; Female; Kainic Acid; Male; Motor Cortex; Pilocarpine; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Seizures; Stereotaxic Techniques | 1991 |
Differential changes in tachykinins after kainic acid-induced seizures in the rat.
Topics: Animals; Brain; Kainic Acid; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Seizures; Substance P; Tachykinins | 1990 |
Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus.
Topics: Animals; Gene Expression Regulation; Hippocampus; Kainic Acid; Nerve Growth Factors; Nucleic Acid Hybridization; Proto-Oncogenes; Rats; RNA; RNA Probes; RNA, Complementary; RNA, Messenger; Seizures | 1991 |
Resistance of the immature hippocampus to seizure-induced synaptic reorganization.
Topics: Animals; Electrophysiology; Hippocampus; Histocytochemistry; In Vitro Techniques; Kainic Acid; Neurons; Pyramidal Tracts; Rats; Receptors, Kainic Acid; Receptors, Neurotransmitter; Seizures; Staining and Labeling; Synapses; Synaptic Transmission | 1991 |
Propagation of acute seizure activities observed by local cerebral glucose metabolism.
Topics: Animals; Autoradiography; Blood Glucose; Brain Mapping; Cats; Electroencephalography; Energy Metabolism; Epilepsy, Frontal Lobe; Frontal Lobe; Hippocampus; Kainic Acid; Macaca mulatta; Motor Cortex; Neural Pathways; Penicillin G; Rats; Seizures | 1991 |
Strain differences in convulsive response to the excitotoxin kainic acid.
Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Kainic Acid; Neurotoxins; Rats; Rats, Inbred Strains; Rats, Inbred WF; Seizures; Status Epilepticus | 1991 |
Effect of neural transplants on seizure frequency and kindling in immature rats following kainic acid.
Topics: Animals; Animals, Newborn; Brain; Disease Susceptibility; Female; Fetal Tissue Transplantation; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1991 |
Changes in rat brain extracellular glutamate concentration during seizures induced by systemic picrotoxin or focal bicuculline injection: an in vivo dialysis study with on-line enzymatic detection.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicuculline; Brain Chemistry; Cerebral Cortex; Dialysis; Electroencephalography; Electroshock; Extracellular Space; Glutamates; Hippocampus; Injections; Kainic Acid; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1991 |
Effect of kainic acid injected into raphe dorsal nucleus on sleep stages in cats.
Topics: Animals; Cats; Electrodiagnosis; Injections; Kainic Acid; Male; Raphe Nuclei; Seizures; Sleep Stages | 1991 |
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Ibotenic Acid; Indicators and Reagents; Kainic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Tetrazoles | 1991 |
A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus.
Topics: Animals; Atropine; Convulsants; Electroencephalography; Hippocampus; Kainic Acid; Male; Octreotide; Picrotoxin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1991 |
An evaluation of the possible protective effects of neonatal striatal transplants against kainic acid-induced lesions.
Topics: Animals; Animals, Newborn; Body Weight; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Kainic Acid; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Transplantation, Homologous | 1991 |
Magnesium sulphate subcutaneously injected protects against kainate-induced convulsions and neurodegeneration: in vivo study on the rat hippocampus.
Topics: Animals; Convulsants; Hippocampus; In Vitro Techniques; Injections, Subcutaneous; Kainic Acid; Magnesium Sulfate; Male; Nerve Degeneration; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1991 |
Analysis of the convulsant-potentiating effects of lithium in rats.
Topics: Animals; Bicuculline; Chlorides; Convulsants; Drug Synergism; Hippocampus; Kainic Acid; Lithium; Lithium Chloride; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1991 |
Systemic administration of kainic acid differentially regulates the levels of prodynorphin and proenkephalin mRNA and peptides in the rat hippocampus.
Topics: Amino Acid Isomerases; Animals; Carrier Proteins; Endorphins; Enkephalins; Gene Expression Regulation; Hippocampus; Injections, Subcutaneous; Kainic Acid; Male; Peptidylprolyl Isomerase; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Seizures | 1991 |
Differential changes in mRNAs encoding for preprotachykinin A and B after kainic acid-induced seizures in the rat.
Topics: Animals; Blotting, Northern; Brain; Cerebral Cortex; Corpus Striatum; Gene Expression; Hippocampus; Kainic Acid; Male; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Tachykinins; Time Factors | 1991 |
[A decrease in the wet-dog shakes response to the second administration of kainic acid in juvenile rats].
Topics: Age Factors; Animals; Behavior, Animal; Hippocampus; Kainic Acid; Limbic System; Male; Rats; Rats, Inbred Strains; Risk Management; Seizures | 1991 |
Domoic acid induced seizure activity in rats.
Topics: Action Potentials; Animals; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Kainic Acid; Male; Neurotoxins; Rats; Rats, Inbred Strains; Seizures | 1991 |
Systemic administration of acromelic acid induces selective neuron damage in the rat spinal cord.
Topics: Animals; Behavior, Animal; Interneurons; Kainic Acid; Lethal Dose 50; Lumbosacral Region; Male; Muscle Spasticity; Paralysis; Rats; Rats, Inbred Strains; Seizures; Spinal Cord | 1991 |
Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid.
Topics: Action Potentials; Animals; Electric Stimulation; Hippocampus; Injections, Subcutaneous; Kainic Acid; Male; Neural Inhibition; Rats; Rats, Inbred Strains; Recurrence; Seizures; Status Epilepticus; Time Factors | 1991 |
Calcium channel blockers and excitatory amino acids.
Topics: Amino Acids; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Seizures | 1991 |
DNQX blockade of amphetamine behavioral sensitization.
Topics: Amphetamine; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinoxalines; Seizures; Stereotyped Behavior | 1991 |
Pertussis toxin potentiates seizures induced by pilocarpine, kainic acid and N-methyl-D-aspartate.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; GTP-Binding Proteins; Injections, Intraventricular; Kainic Acid; Lithium; Male; N-Methylaspartate; Pertussis Toxin; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques; Virulence Factors, Bordetella | 1991 |
Differential changes in tachykinins in the rat brain after drug-induced seizures.
Topics: Animals; Brain; Kainic Acid; Kindling, Neurologic; Male; Neuropeptides; Organ Specificity; Pentylenetetrazole; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Seizures; Tachykinins | 1991 |
Role of nitric oxide in the genesis of excitatory amino acid-induced seizures from the deep prepiriform cortex.
Topics: Animals; Arginine; Electric Stimulation; Electroencephalography; Kainic Acid; Male; Methylene Blue; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred Strains; Seizures; Temporal Lobe | 1991 |
Hippocampal glutamine synthetase: insensitivity to glucocorticoids and stress.
Topics: Adrenalectomy; Animals; Corticosterone; Glutamate-Ammonia Ligase; Hippocampus; Kainic Acid; Male; Muscles; Rats; Rats, Inbred Strains; Reference Values; Seizures; Stress, Physiological | 1990 |
Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels.
Topics: Animals; Bivalvia; Brain; Disease Outbreaks; Electromyography; Food Contamination; Glucose; Humans; Kainic Acid; Marine Toxins; Memory Disorders; Motor Neurons; Myoclonus; Necrosis; Nervous System Diseases; Neuromuscular Diseases; Neurotransmitter Agents; Prince Edward Island; Seizures; Temporal Lobe; Tomography, Emission-Computed | 1990 |
Effect of anticonvulsant treatment on kainic acid-induced increases in peptide levels.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamate Decarboxylase; Kainic Acid; Male; Neuropeptide Y; Neuropeptides; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Somatostatin | 1990 |
Transmitter release in hippocampal slices from rats with limbic seizures produced by systemic administration of kainic acid.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Limbic System; Male; Potassium; Rats; Rats, Inbred Strains; Seizures; Serotonin | 1990 |
Enhanced rate of expression and biosynthesis of neuropeptide Y after kainic acid-induced seizures.
Topics: Amygdala; Animals; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Frontal Lobe; Gene Expression; Hippocampus; Kainic Acid; Male; Neuropeptide Y; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Tritium; Tyrosine | 1991 |
Systemic kainic acid administration in rats: effects on kynurenic acid production in vitro and in vivo.
Topics: Animals; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Olfactory Pathways; Rats; Rats, Inbred Strains; Seizures; Veratridine | 1991 |
Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage.
Topics: Animals; Body Weight; Brain; Brain Damage, Chronic; Eflornithine; Injections, Intraperitoneal; Kainic Acid; Male; Morbidity; Mortality; Polyamines; Rats; Rats, Inbred Strains; Seizures | 1991 |
Kainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis.
Topics: Age Factors; Animals; Cerebellum; Electroencephalography; Glycine; Hippocampus; Kainic Acid; Nutrition Disorders; Rats; Seizures; Spinal Cord; Valproic Acid | 1990 |
Effect of nifedipine and anticonvulsants on kainic acid-induced seizures in mice.
Topics: Animals; Anticonvulsants; Female; Kainic Acid; Mice; Nifedipine; Reaction Time; Seizures | 1990 |
Differential effects of antiepileptic drugs and beta-carbolines on seizures induced by excitatory amino acids.
Topics: Animals; Anticonvulsants; Carbolines; Convulsants; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Quisqualic Acid; Seizures | 1990 |
Systemic administration of kainic acid produces elevations in TRH in rat central nervous system.
Topics: Animals; Brain Chemistry; Hippocampus; Kainic Acid; Kinetics; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Seizures; Thyrotropin-Releasing Hormone; Time Factors | 1990 |
Audiogenic seizures evoked in DBA/2 mice induce c-fos oncogene expression into subcortical auditory nuclei.
Topics: Acoustic Stimulation; Animals; Brain; Gene Expression Regulation; Kainic Acid; Mice; Mice, Inbred DBA; Organ Specificity; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Seizures | 1990 |
Hypoxia prevents seizures and neuronal damages of the hippocampus induced by kainic acid in rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Carbon Dioxide; Hippocampus; Hydrogen-Ion Concentration; Hypoxia; Kainic Acid; Male; Neurons; Oxygen; Rats; Rats, Inbred Strains; Seizures | 1990 |
Uncoupling of local blood flow and metabolism in the hippocampal CA3 in kainic acid-induced limbic seizure status.
Topics: Animals; Antipyrine; Autoradiography; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Deoxyglucose; Glucose; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Limbic System; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques | 1990 |
Kainic acid induced seizure of thalamic focus.
Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Female; Hippocampus; Kainic Acid; Male; Neural Pathways; Reticular Formation; Seizures; Thalamic Nuclei | 1990 |
Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Brain Chemistry; Immunoenzyme Techniques; Ischemic Attack, Transient; Kainic Acid; Male; Molecular Sequence Data; Nerve Tissue Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Seizures | 1990 |
Some mechanisms of brain edema studied in a kainic acid model.
Topics: Animals; Brain Edema; Disease Models, Animal; Kainic Acid; Limbic System; Neurons; Rats; Seizures | 1990 |
NMDA antagonist properties of gamma-L-glutamyl-L-aspartate demonstrated on chemically induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dipeptides; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid.
Topics: Animals; Azo Compounds; Chelating Agents; Dithizone; Ditiocarb; Kainic Acid; Male; Rats; Rats, Inbred F344; Reaction Time; Seizures; Zinc | 1990 |
Spider toxin (JSTX-3) inhibits the convulsions induced by glutamate agonists.
Topics: Animals; Arthropod Venoms; Dose-Response Relationship, Drug; Injections, Intraventricular; Kainic Acid; Mice; Motor Activity; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures; Spider Venoms | 1990 |
[Neuroexcitotoxic action of db-cAMP: lesioning of neuronal cell bodies while sparing fibers of passage].
Topics: Acetylcholinesterase; Amygdala; Animals; Bucladesine; Cerebral Cortex; Hippocampus; Kainic Acid; Male; Nerve Fibers; Neurons; Rats; Rats, Inbred Strains; Seizures | 1990 |
Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors.
Topics: Animals; Autoradiography; Diazepam; Flunitrazepam; Kainic Acid; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Muscarinic; Seizures; Soman; Tritium; Video Recording | 1990 |
Evidence for a role of glycine in area tempestas for triggering convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Carbachol; Cerebral Cortex; Glycine; Kainic Acid; Kynurenic Acid; Male; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Influence of kynurenine treatment on open-field activity, elevated plus-maze, avoidance behaviors and seizures in rats.
Topics: Animals; Avoidance Learning; Exploratory Behavior; Kainic Acid; Kynurenine; Learning; Male; Rats; Rats, Inbred Strains; Seizures | 1990 |
The release of alpha-neoendorphin from rat hippocampus following kainic acid-induced seizures.
Topics: Animals; Endorphins; Enkephalins; Hippocampus; Kainic Acid; Male; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures | 1990 |
Theophylline reduces cerebral hyperaemia and enhances brain damage induced by seizures.
Topics: Adenosine; Animals; Cerebrovascular Circulation; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures; Theophylline | 1990 |
Granule cells in the ventral, but not dorsal, dentate gyrus are essential for kainic acid-induced wet dog shakes.
Topics: Animals; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred F344; Seizures; Stereotyped Behavior | 1990 |
Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid.
Topics: Animals; Brain; Dinoprost; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; Indomethacin; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures; SRS-A | 1990 |
Anticonvulsant effect of N-ethylcarboxamidoadenosine against kainic acid-induced behavioral seizures in the rat prepiriform cortex.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dilazep; Kainic Acid; Limbic System; Male; Rats; Rats, Inbred Strains; Seizures; Theophylline | 1990 |
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ethanol; Kainic Acid; Male; N-Methylaspartate; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Spontaneous secondarily generalized seizures induced by a single microinjection of kainic acid into unilateral amygdala in cats.
Topics: Amygdala; Animals; Cats; Electroencephalography; Hippocampus; Kainic Acid; Microinjections; Seizures | 1985 |
Kainic acid induced seizures: changes in somatostatin, substance P and neurotensin.
Topics: Amygdala; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Cysteamine; Frontal Lobe; Hippocampus; Kainic Acid; Male; Nerve Tissue Proteins; Neurotensin; Rats; Rats, Inbred Strains; Seizures; Somatostatin; Substance P; Time Factors | 1986 |
[Acute effect of penicillin G on feline models of focal epilepsy].
Topics: Amygdala; Animals; Cats; Convulsants; Disease Models, Animal; Epilepsies, Partial; Injections, Intraperitoneal; Kainic Acid; Kindling, Neurologic; Limbic System; Penicillin G; Reaction Time; Seizures | 1989 |
Influence of clonazepam and valproate on kainate-induced model of psychomotor seizures.
Topics: Animals; Anticonvulsants; Clonazepam; Kainic Acid; Rats; Seizures; Valproic Acid | 1989 |
Pronounced increases in brain levels of calcitonin gene-related peptide after kainic acid induced seizures.
Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Chromatography, High Pressure Liquid; Glutamate Decarboxylase; Kainic Acid; Male; Mannitol; Pentylenetetrazole; Radioimmunoassay; Rats; Rats, Inbred Strains; Seizures | 1989 |
The interaction between kappa-opioid agonist, U-50, 488H, and kainic acid: behavioral and histological assessments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Brain; Kainic Acid; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Seizures | 1989 |
Changes in cholinergic but not in GABAergic markers in amygdala, piriform cortex, and nucleus basalis of the rat brain following systemic administration of kainic acid.
Topics: Amygdala; Animals; Basal Ganglia; Behavior, Animal; Biomarkers; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Limbic System; Male; Olfactory Pathways; Parasympathetic Nervous System; Rats; Receptors, GABA-A; Seizures; Substantia Innominata | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors | 1989 |
Specific lesions of rat spinal interneurons induced by systemic administration of acromelic acid, a new potent kainate analogue.
Topics: Animals; Dose-Response Relationship, Drug; Interneurons; Kainic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures; Spinal Cord | 1989 |
Concentrations of mRNAs encoding for preprosomatostatin and preprocholecystokinin are increased after kainic acid-induced seizures.
Topics: Animals; Cholecystokinin; Kainic Acid; Male; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Somatostatin | 1989 |
Effect of kainate-induced seizures on tissue trace element concentrations in the rat.
Topics: Animals; Brain; Copper; Iron; Kainic Acid; Kidney; Liver; Manganese; Myocardium; Rats; Rats, Inbred Strains; Seizures; Tissue Distribution; Trace Elements; Zinc | 1989 |
Ethosuximide affects both pentylenetetrazole- and kainate-induced clonic seizures but differentiates between tonic-clonic seizures.
Topics: Animals; Anticonvulsants; Ethosuximide; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1989 |
The renal effects of kainic acid.
Topics: Acidosis; Animals; Glomerular Filtration Rate; Inulin; Kainic Acid; Kidney; Male; Rats; Seizures; Sodium | 1989 |
Effects of carbamazepine and phenobarbital on kainic acid-induced model of psychomotor seizures during ontogenesis in the rat.
Topics: Aging; Animals; Carbamazepine; Dose-Response Relationship, Drug; Kainic Acid; Male; Phenobarbital; Rats; Rats, Inbred Strains; Seizures | 1989 |
Homocysteic acid: convulsant action of stereoisomers in mice.
Topics: Animals; Aspartic Acid; Convulsants; Homocysteine; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Seizures; Stereoisomerism | 1989 |
Regional voltage map of the hippocampus during seizures.
Topics: Animals; Bicuculline; Diagnosis, Computer-Assisted; Electroencephalography; Electrophysiology; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures; Trypan Blue | 1989 |
Translocation of zinc may contribute to seizure-induced death of neurons.
Topics: Amygdala; Animals; Cell Survival; Cerebellum; Hippocampus; In Vitro Techniques; Kainic Acid; Nerve Degeneration; Quinolines; Rats; Seizures; Sulfonamides; Toluene; Zinc | 1989 |
Glucocorticoids potentiate kainic acid-induced seizures and wet dog shakes.
Topics: Adrenalectomy; Animals; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Glucocorticoids; Kainic Acid; Male; Rats; Rats, Inbred F344; Seizures | 1989 |
Limbic seizures without brain damage after injection of low doses of kainic acid into the amygdala of freely moving rats.
Topics: Amygdala; Animals; Brain; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Rats; Rats, Inbred Strains; Seizures | 1989 |
Kainic acid-induced seizures: changes in brain extracellular ions as assessed by intracranial microdialysis.
Topics: Animals; Brain; Calcium; Cations; Cerebral Cortex; Dialysis; Hippocampus; Kainic Acid; Male; Potassium; Rats; Rats, Inbred Strains; Seizures; Sodium | 1989 |
Activation of adenosine receptors suppresses behavioral seizures induced by kainic acid in the rat prepiriform cortex.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Kainic Acid; Rats; Receptors, Purinergic; Seizures | 1989 |
Ibotenic acid-induced nigral lesion and limbic seizure in cats.
Topics: Animals; Brain Diseases; Cats; Electroencephalography; Female; Ibotenic Acid; Kainic Acid; Limbic System; Male; Oxazoles; Seizures; Substantia Nigra | 1989 |
Domoic acid poisoning and mussel-associated intoxication: preliminary investigations into the response of mice and rats to toxic mussel extract.
Topics: Animals; Bivalvia; Dose-Response Relationship, Drug; Feces; Female; Hippocampus; Kainic Acid; Male; Mice; Nervous System Diseases; Rats; Retina; Seizures; Tissue Extracts | 1989 |
[Limbic seizure and ibotenic acid-induced lesions of substantia innominata in cats].
Topics: Amygdala; Animals; Basal Ganglia; Cats; Cholinergic Fibers; Ibotenic Acid; Kainic Acid; Limbic System; Oxazoles; Seizures; Substantia Innominata | 1989 |
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Oxadiazoles; Pilocarpine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures | 1988 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism | 1985 |
Regional changes in transmitter amino acids during focal and generalized seizures in rats.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Brain; Glucose; Hippocampus; Kainic Acid; Lactates; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Seizures | 1985 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium | 1985 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1986 |
Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Enkephalins; Hippocampus; Histocytochemistry; Immunochemistry; Kainic Acid; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred F344; RNA, Messenger; Seizures | 1986 |
Limbic seizures induced by systemically applied kainic acid: how much kainic acid reaches the brain?
Topics: Age Factors; Animals; Blood-Brain Barrier; Brain; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; Rats; Seizures | 1986 |
On the role of seizure activity and endogenous excitatory amino acids in mediating seizure-associated hippocampal damage.
Topics: Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Survival; Dendrites; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Kainic Acid; Neurotransmitter Agents; Seizures; Time Factors | 1986 |
Kainic acid as a tool to study the regulation and function of opioid peptides in the hippocampus.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Methionine; Hippocampus; Kainic Acid; Peptide Fragments; Rats; Seizures | 1987 |
Dentate granule cells are essential for kainic acid-induced wet dog shakes but not for seizures.
Topics: Animals; Behavior, Animal; Dynorphins; Enkephalin, Methionine; Granulocytes; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Organ Size; Radioimmunoassay; Rats; Rats, Inbred F344; Seizures | 1988 |
Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1988 |
Seizures induce dramatic and distinctly different changes in enkephalin, dynorphin, and CCK immunoreactivities in mouse hippocampal mossy fibers.
Topics: Animals; Cholecystokinin; Dynorphins; Enkephalins; Hippocampus; Immunochemistry; Kainic Acid; Mice; Nerve Fibers; Seizures | 1988 |
The convulsant effects of kainic acid microinjections into cerebral cortex are concentration but not laminar dependent.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Evoked Potentials, Visual; Kainic Acid; Microinjections; Osmolar Concentration; Seizures; Visual Cortex | 1989 |
Regional calcium accumulation and kainic acid (KA)-induced limbic seizure status in rats.
Topics: Animals; Autoradiography; Brain; Calcium; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1989 |
Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures.
Topics: Animals; Brain Chemistry; Clonidine; Diazepam; Haloperidol; Kainic Acid; Male; Metergoline; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Seizures | 1985 |
GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Baclofen; Benzodiazepinones; Bicuculline; Ethanol; Geniculate Bodies; Inferior Colliculi; Kainic Acid; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stereoisomerism; Substance Withdrawal Syndrome | 1986 |
Effect of seizures induced by intra-amygdaloid kainic acid on kainic acid binding sites in rat hippocampus and amygdala.
Topics: Amygdala; Animals; Cell Membrane; Hippocampus; Kainic Acid; Kinetics; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter; Seizures | 1986 |
Inciting excitotoxic cytocide among central neurons.
Topics: Action Potentials; Animals; Brain; Cell Survival; Chick Embryo; Cholinergic Fibers; Disease Models, Animal; Edema; Epilepsies, Partial; Folic Acid; Hippocampus; Hypoxia; Kainic Acid; Ketamine; Microscopy, Electron; Parasympathomimetics; Phencyclidine; Piperidines; Seizures; Synaptic Transmission; Thalamus | 1986 |
Selective and non-selective seizure related brain damage produced by kainic acid.
Topics: Animals; Brain; Brain Mapping; Deoxyglucose; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Limbic System; Receptors, Kainic Acid; Receptors, Neurotransmitter; Seizures | 1986 |
Modulation of opioid peptide metabolism by seizures: differentiation of opioid subclasses.
Topics: Amygdala; Animals; Electroshock; Endorphins; Gerbillinae; Hippocampus; Kainic Acid; Kindling, Neurologic; Rats; Receptors, Opioid; Seizures; Septal Nuclei | 1986 |
The effect of two novel dipeptide antagonists of excitatory amino acid neurotransmission on the high pressure neurological syndrome in the rat.
Topics: Animals; Aspartic Acid; Central Nervous System Diseases; Glutamates; Glutamine; High Pressure Neurological Syndrome; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1987 |
Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats.
Topics: Animals; Aspartic Acid; Corpus Striatum; Globus Pallidus; Kainic Acid; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1988 |
Role of early edema in the development of regional seizure-related brain damage.
Topics: Animals; Brain; Brain Edema; Hippocampus; Kainic Acid; Male; Mannitol; Necrosis; Parietal Lobe; Rats; Rats, Inbred Strains; Seizures; Specific Gravity; Temporal Lobe; Thalamus | 1987 |
Continuous determination of the cerebrovascular changes induced by bicuculline and kainic acid in unanaesthetized spontaneously breathing rats.
Topics: Action Potentials; Animals; Bicuculline; Blood Pressure; Brain; Carbon Dioxide; Cerebral Cortex; Cerebrovascular Circulation; Evoked Potentials; Hippocampus; Kainic Acid; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Seizures | 1987 |
Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Female; Harmaline; Horseradish Peroxidase; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Kainic Acid; Limbic System; Peroxidases; Rats; Rats, Inbred Strains; Seizures | 1988 |
Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid.
Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1988 |
Protective effects of mossy fiber lesions against kainic acid-induced seizures and neuronal degeneration.
Topics: Animals; Colchicine; Electroencephalography; Functional Laterality; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Reaction Time; Seizures | 1988 |
Chemical adrenalectomy reduces hippocampal damage induced by kainic acid.
Topics: Adrenal Cortex; Animals; Electroencephalography; Glucocorticoids; Hippocampus; Kainic Acid; Male; Metyrapone; Rats; Rats, Inbred Strains; Seizures | 1988 |
Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats.
Topics: Animals; Cerebellar Nuclei; Dendrites; Hippocampus; Kainic Acid; Rats; Rats, Inbred Strains; Seizures | 1988 |
[Regional cerebral blood flow during development of limbic seizures induced by kainic acid (KA) microinjection into unilateral amygdala in chronic cats].
Topics: Amygdala; Animals; Astrocytes; Cats; Cell Division; Cerebrovascular Circulation; Chronic Disease; Disease Models, Animal; Hippocampus; Hydrogen; Kainic Acid; Limbic System; Microinjections; Seizures | 1988 |
Failure of kindling to alter susceptibility to kainic acid.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Reaction Time; Seizures | 1988 |
On the relation between seizures and brain lesions after intracerebroventricular kainic acid.
Topics: Animals; Brain; Electroencephalography; Injections, Intraventricular; Kainic Acid; Limbic System; Male; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains; Seizures | 1988 |
Effects of serial administration of kainic acid on the developing brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Injections, Intraperitoneal; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Seizures | 1988 |
CL 218-872 pretreatment and intervention block kainate-induced convulsions and neuropathology.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Kainic Acid; Male; Organ Specificity; Pyridazines; Rats; Rats, Inbred Strains; Seizures | 1988 |
Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence study.
Topics: Animals; Hippocampus; Kainic Acid; Microscopy, Fluorescence; Rats; Rats, Inbred Strains; Reference Values; Seizures; Zinc | 1988 |
Thalamic control of neocortical activation: a critical re-evaluation.
Topics: Animals; Cerebral Cortex; Electric Conductivity; Kainic Acid; Rats; Reserpine; Scopolamine; Seizures; Somatosensory Cortex; Thalamus | 1988 |
Brain damage caused by seizure activity.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Limbic System; Rats; Seizures | 1987 |
Pregnancy decreases the frequency of spontaneous recurrent seizures in rats with kainic acid lesions of the hippocampus.
Topics: Animals; Female; Hippocampus; Kainic Acid; Lactation; Pregnancy; Pregnancy Complications; Rats; Rats, Inbred Strains; Seizures | 1987 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diazepam; Electroencephalography; Hippocampus; Injections; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
Anterior thalamic mediation of generalized pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Female; Guinea Pigs; Kainic Acid; Microinjections; Muscimol; Pentylenetetrazole; Seizures; Stereotaxic Techniques; Thalamic Nuclei; Vigabatrin | 1986 |
Unusual interactions of excitatory amino acid receptor agonists: alpha- and beta-kainate antagonize motor responses to N-methyl-D-aspartate in rodents.
Topics: Animals; Aspartic Acid; Electromyography; Kainic Acid; Male; Mice; Motor Activity; Muscle Spasticity; Muscle Tonus; N-Methylaspartate; Seizures; Stereoisomerism | 1987 |
Changes in extracellular amino acids during soman- and kainic acid-induced seizures.
Topics: Amino Acids; Animals; Extracellular Space; Kainic Acid; Kinetics; Male; Rats; Rats, Inbred Strains; Seizures; Soman | 1987 |
[Serial changes in evoked potentials in kainic acid (KA)-induced limbic seizures in chronic cats].
Topics: Amygdala; Animals; Cats; Electroencephalography; Evoked Potentials; Hippocampus; Kainic Acid; Limbic System; Microinjections; Reaction Time; Seizures | 1987 |
Histamine H2-receptors participate in the formation of brain edema induced by kainic acid in rat thalamus.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Kainic Acid; Male; Ranitidine; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Seizures; Thalamus | 1987 |
Attenuation of cerebral glucose use in kainic acid-treated rats by diazepam.
Topics: Animals; Autoradiography; Behavior, Animal; Brain; Diazepam; Glucose; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1987 |
Excitotoxic mechanisms of epileptic brain damage.
Topics: Administration, Topical; Amygdala; Animals; Axons; Biomechanical Phenomena; Brain; Choline; Cholinesterase Inhibitors; Convulsants; Corpus Striatum; Epilepsy; Folic Acid; Injections; Kainic Acid; Lithium; Motor Cortex; Neural Pathways; Neurotoxins; Piperidines; Rats; Seizures; Somatosensory Cortex | 1986 |
Increased lipid peroxide formation in the rat forebrain during kainic acid seizures.
Topics: Animals; Kainic Acid; Lipid Peroxides; Male; Malondialdehyde; Rats; Seizures; Telencephalon | 1986 |
Potentiating effect of morphine on seizures induced by kainic acid in rats. An electroencephalographic study.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Kainic Acid; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Seizures | 1986 |
Comparison of seizures and brain lesions produced by intracerebroventricular kainic acid and bicuculline methiodide.
Topics: Animals; Bicuculline; Brain Diseases; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1986 |
Increased brain levels of cholecystokinin octapeptide after kainic acid-induced seizures in the rat.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures; Sincalide | 1986 |
Dietary pyridoxine and the susceptibility to limbic motor seizures in rats.
Topics: Animals; Disease Susceptibility; Female; Kainic Acid; Rats; Seizures; Vitamin B 6 Deficiency | 1986 |
Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.
Topics: Animals; Baclofen; Behavior, Animal; Brain; Electroencephalography; Injections, Intraventricular; Kainic Acid; Limbic System; Male; Phenobarbital; Rats; Rats, Inbred Strains; Seizures; Time Factors | 1986 |
Long term sequelae of parenteral administration of kainic acid.
Topics: Amygdala; Animals; Brain; Cerebral Cortex; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Limbic System; Neuroglia; Rats; Sclerosis; Seizures; Thalamic Nuclei; Time Factors | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; Epilepsy; Kainic Acid; Methionine Sulfoximine; Pentylenetetrazole; Pyridoxine; Rabbits; Seizures | 1986 |
Extravasated protein as a cause of limbic seizure-induced brain damage: an evaluation using kainic acid.
Topics: Amygdala; Animals; Blood Proteins; Blood-Brain Barrier; Brain Mapping; Cell Survival; Female; Hippocampus; Immunoglobulin G; Kainic Acid; Necrosis; Rats; Seizures; Time Factors | 1986 |
Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Hippocampus; Kainic Acid; Limbic System; Male; Nerve Degeneration; Neural Inhibition; Neural Pathways; Phenobarbital; Rats; Seizures; Time Factors | 1986 |
Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Kainic Acid; Mice; Mice, Inbred DBA; Mice, Inbred Strains; N-Methylaspartate; Oxadiazoles; Piperazines; Pyrrolidines; Quinolinic Acids; Quisqualic Acid; Seizures | 1985 |
Effects of dexamethasone on brain edema induced by kainic acid seizures.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Dexamethasone; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1986 |
Distant blood-brain barrier opening in subfields of the rat hippocampus after intrastriatal injections of kainic acid but not ibotenic acid.
Topics: Animals; Blood-Brain Barrier; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Oxazoles; Pinocytosis; Rats; Rats, Inbred Strains; Seizures | 1986 |
Long-term effects of febrile convulsion on seizure susceptibility in P77PMC rat--resistant to acoustic stimuli but susceptible to kainate-induced seizures.
Topics: Acoustic Stimulation; Aging; Animals; Disease Susceptibility; Female; Fever; Immunity, Innate; Kainic Acid; Male; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Time Factors | 1985 |
Kainic acid-induced seizures: dose-relationship of behavioural, neurochemical and histopathological changes.
Topics: Animals; Biogenic Amines; Brain; Brain Edema; Kainic Acid; Male; Necrosis; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures | 1985 |
Accumulation of calcium in the rat hippocampus during kainic acid seizures.
Topics: Animals; Calcium; Dendrites; Hippocampus; Histocytochemistry; Kainic Acid; Male; Microscopy, Electron; Mitochondria; Rats; Seizures; Synapses | 1985 |