kainic acid has been researched along with Encephalopathy, Toxic in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.96) | 18.2507 |
| 2000's | 23 (45.10) | 29.6817 |
| 2010's | 21 (41.18) | 24.3611 |
| 2020's | 6 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, Y; Hsieh, TY; Wang, SJ | 1 |
| Bouroubi, NEH; Cao, ST; Chen, YX; Liu, HC; Long, XP; Nie, ZY; Xia, JL; Zheng, XF | 1 |
| Baldessari, A; Bammler, TK; Burbacher, TM; Crouthamel, B; English, CN; Grant, KS; Harry, GJ; Isoherranen, N; Jing, J; Li, JL; MacDonald, JW; McKain, N; Petroff, RL; Richards, T; Shum, S; Williams, C | 1 |
| Grattan, LM | 1 |
| Gill, S; Kumara, VMR | 1 |
| Burbacher, TM; Crouthamel, B; Grant, KS; Isoherranen, N; Jing, J; McKain, N; Murias, M; Petroff, R; Shum, S | 1 |
| Aluru, N; Hahn, ME; Panlilio, JM | 1 |
| Badia, A; Camps, P; Muñoz-Torrero, D; Pérez, B; Relat, J; Victòria Clos, M | 1 |
| Lauková, M; Shakarjian, MP; Velíšek, L; Velíšková, J | 1 |
| Hsieh, HL; Hsieh, TY; Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Cynader, M; Fernando, S; Leavitt, BR; Lu, G; Petkau, TL; Zhu, S | 1 |
| Govindasamy, C; Mustapha, Z; Sirajudeen, KN; Suhaili, D; Swamy, M | 1 |
| Doihara, T; Kobayashi, N; Li, C; Matsuda, S; Nabeka, H; Saito, S; Shimokawa, T; Takechi, H; Uematsu, K; Yamamiya, K | 1 |
| Almeida, JS; Arthur, JM; Chaves, JM; Ferrante, JA; Gulland, FM; Janech, MG; Neely, BA; Soper, JL | 1 |
| Bisilimi, K; Colivicchi, MA; Della Corte, L; Freinbichler, W; Linert, W; Misini, B; Tipton, KF | 1 |
| Barbeito, CG; Martínez, A; Nishida, F; Portiansky, EL; Zanuzzi, CN | 1 |
| Chang, CY; Chou, SS; Huang, SK; Lin, TY; Lu, CW; Wang, SJ; Wang, YC | 1 |
| Aschner, M; Gupta, RC; Milatovic, D; Montine, TJ; Zaja-Milatovic, S | 1 |
| Behl, C; Clement, AB; Deussing, JM; Hanstein, R; Holsboer, F; Lu, A; Wurst, W | 1 |
| Ando, K; Higuchi, M; Inaji, M; Ji, B; Lee, VM; Maeda, J; Okauchi, T; Ono, M; Sawada, M; Staufenbiel, M; Suhara, T; Suzuki, K; Trojanowski, JQ; Zhang, MR | 1 |
| Bedner, P; Frank, S; Hüttmann, K; Steinhäuser, C; Theis, M; Theofilas, P | 1 |
| Gao, S; Ho, G; Kng, YL; Kumar, S; Loh, MY; Min, XS; Zhuo, L | 1 |
| Benkovic, SA; Miller, DB; O'Callaghan, JP | 1 |
| Agostinho, PM; Cognato, GP; Cunha, RA; Hockemeyer, J; Müller, CE; Souza, DO | 1 |
| Costa, LG; Faustman, EM; Giordano, G | 1 |
| Connor, TJ; Gleeson, LC; Griffin, EW; Harkin, A; Ryan, KJ | 1 |
| Afonso, A; Azevedo, J; Cervantes, R; Gago-Martinez, A; Lobo-da-Cunha, A; Monteiro, R; Nogueira, I; Rivera, S; Vasconcelos, V | 1 |
| Ee, SM; Farooqui, AA; Jenner, AM; Jittiwat, J; Kim, JH; Ong, ES; Ong, WY | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Wilhelm, EA | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Rambo, LM; Ribeiro, LR; Roman, SS; Royes, LF; Wilhelm, EA | 1 |
| Friedman, LK; Leheste, JR; Rafiuddin, A; Rudenko, V | 1 |
| Denslow, N; Glushakova, OY; Hayes, RL; Jeromin, A; Johnson, D; Martinez, J; Mondello, S; Streeter, J | 1 |
| Baron, AW; Blain, PG; Judge, SJ; Morris, CM; Rens, N; Rushton, SP | 1 |
| Benkovic, SA; Miller, DB; O'Callaghan, JP; Sriram, K | 1 |
| Angehagen, M; Ben-Menachem, E; Hansson, E; Rönnbäck, L | 1 |
| Gudelsky, GA; Mulchahey, JJ; Zemlan, FP | 1 |
| Adamo, EB; Altavilla, D; Calabresi, P; Campo, GM; Costa, C; Esposito, M; Ientile, R; Marini, H; Marini, R; Minutoli, L; Passaniti, M; Pisani, F; Squadrito, F | 1 |
| Shoham, S; Youdim, MB | 1 |
| Yan, T; Zhou, MJ | 1 |
| Behl, C; Conrad, S; Goodenough, S; Skutella, T | 1 |
| Carlson, KM; Wagner, GC | 1 |
| Antoniou, K; Kitraki, E; Papalexi, E | 1 |
| Cinini, SM; Medeiros, MA; Mello, LE; Perez-Mendes, P; Tufik, S | 1 |
| Li, K; Milatovic, D; Montine, KS; Montine, TJ; VanRollins, M | 1 |
| Cho, IH; Han, PL; Kim, JB; Kim, SW; Kim, TK; Lee, JK; Lee, KW | 1 |
| Ho, G; Zhang, C; Zhuo, L | 1 |
| Matsumoto, K; Murakami, Y; Sumanont, Y; Tohda, M; Vajragupta, O; Watanabe, H | 1 |
| Ju, KL; Manley, NC; Sapolsky, RM | 1 |
| Cho, YJ; Jhoo, WK; Kim, HC; Wie, MB | 1 |
| Bing, G; Choi, YS; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, DW; Park, ES; Ryu, JR; Shin, CY; Shin, EJ | 1 |
| Beart, PM; Giardina, SF | 1 |
2 review(s) available for kainic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Biosynthesis and Detection of Domoic Acid from Diatom
Topics: Diatoms; Humans; Kainic Acid; Metabolic Networks and Pathways; Neurotoxicity Syndromes; Shellfish Poisoning | 2023 |
Domoic acid as a developmental neurotoxin.
Topics: Animals; Environmental Exposure; Female; Humans; Kainic Acid; Male; Neurotoxicity Syndromes; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects | 2010 |
49 other study(ies) available for kainic acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway.
Topics: Alkaloids; Animals; Benzodioxoles; Excitatory Amino Acid Agonists; Glycogen Synthase Kinase 3 beta; Hippocampus; Kainic Acid; Nerve Growth Factor; Neuroprotection; Neuroprotective Agents; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats | 2022 |
Prolonged, Low-Level Exposure to the Marine Toxin, Domoic Acid, and Measures of Neurotoxicity in Nonhuman Primates.
Topics: Animals; Cytokines; Female; Kainic Acid; Macaca fascicularis; Marine Toxins; Neurotoxicity Syndromes | 2022 |
Invited Perspective: The Relevance of Animal Models of Domoic Acid Neurotoxicity to Human Health.
Topics: Animals; Humans; Kainic Acid; Models, Animal; Neurotoxicity Syndromes | 2022 |
Detecting Neurodevelopmental Toxicity of Domoic Acid and Ochratoxin A Using Rat Fetal Neural Stem Cells.
Topics: Animals; Astrocytes; Cell Differentiation; Cells, Cultured; Doublecortin Protein; Kainic Acid; Neural Stem Cells; Neurons; Neurotoxicity Syndromes; Neurotoxins; Ochratoxins; Oligodendroglia; Rats; Rats, Sprague-Dawley | 2019 |
Power spectrum analysis of EEG in a translational nonhuman primate model after chronic exposure to low levels of the common marine neurotoxin, domoic acid.
Topics: Animals; Brain; Brain Waves; Electroencephalography; Female; Kainic Acid; Macaca; Neurotoxicity Syndromes; Time Factors; Toxicity Tests, Chronic | 2020 |
Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model.
Topics: Animals; Behavior, Animal; Harmful Algal Bloom; Kainic Acid; Nervous System; Neurotoxicity Syndromes; Water Pollutants, Chemical; Zebrafish | 2020 |
Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation.
Topics: Aminoquinolines; Animals; Apoptosis; Biomarkers; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Encephalitis; Heterocyclic Compounds, 4 or More Rings; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neuronal Plasticity; Neuroprotective Agents; Neurotoxicity Syndromes | 2018 |
Developmental and sex differences in tetramethylenedisulfotetramine (TMDT)-induced syndrome in rats.
Topics: Animals; Brain; Bridged-Ring Compounds; Cell Death; Dose-Response Relationship, Drug; Electroencephalography; Female; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Random Allocation; Rats, Sprague-Dawley; Seizures; Sex Characteristics | 2018 |
Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.
Topics: Animals; Brain; Cistanche; Cytokines; Disease Models, Animal; Epilepsy; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Glycosides; Inflammation; Kainic Acid; Male; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2018 |
Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Topics: Animals; Fluoresceins; Granulins; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; Mice, Knockout; Neurotoxicity Syndromes; Neurotoxins; Nitro Compounds; Progranulins; Propionates; Quinolinic Acid; Seizures | 2013 |
Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain.
Topics: Animals; Apitherapy; Apoptosis; Brain; Caspase 3; Dietary Supplements; Kainic Acid; Male; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Nitric Oxide Synthase; Propolis; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Prosaposin overexpression following kainic acid-induced neurotoxicity.
Topics: Animals; Cerebral Cortex; Choroid Plexus; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Interneurons; Kainic Acid; Lysosomes; Male; Microscopy, Fluorescence; Nerve Degeneration; Neurons; Neurotoxicity Syndromes; Rats; Rats, Wistar; Saposins; Seizures; Up-Regulation | 2014 |
Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis.
Topics: Animals; Apolipoproteins E; Eosinophils; Female; Kainic Acid; Machine Learning; Male; Neuromuscular Depolarizing Agents; Neurotoxicity Syndromes; Proteomics; Retrospective Studies; Sea Lions; Support Vector Machine | 2014 |
Continuous monitoring of highly reactive oxygen radicals during in vivo microdialysis.
Topics: Analysis of Variance; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescence; Kainic Acid; Male; Microdialysis; Neostriatum; Neurotoxicity Syndromes; Online Systems; Phthalic Acids; Rats; Rats, Wistar; Reactive Oxygen Species; Taurine; Time Factors | 2015 |
Functional and histopathological changes induced by intraparenchymal injection of kainic acid in the rat cervical spinal cord.
Topics: Analysis of Variance; Animals; Body Weight; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Functional Laterality; Kainic Acid; Male; Motor Activity; Neurotoxicity Syndromes; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reflex; Sensory Thresholds; Spinal Cord; Time Factors | 2015 |
Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hesperidin; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neuroprotective Agents; Neurotoxicity Syndromes; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptosomes; Tetrodotoxin | 2015 |
Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum.
Topics: Animals; Cerebrum; Citrulline; Dendrites; Disease Models, Animal; Drug Interactions; Female; Functional Laterality; Isoprostanes; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase; Oxidative Stress | 2008 |
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Death; Corticotropin-Releasing Hormone; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Indoles; Intermediate Filament Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurotoxicity Syndromes; Plant Lectins; Proteins; Reaction Time; RNA, Untranslated; Seizures | 2008 |
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cell Line, Transformed; Cell Transplantation; Central Nervous System; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurotoxicity Syndromes; Oxidopamine; Phenyl Ethers; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, GABA-A; tau Proteins | 2008 |
The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 3; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neurotoxicity Syndromes; Phosphopyruvate Hydratase; Proto-Oncogene Proteins; Seizures; Stereotaxic Techniques; Time Factors | 2009 |
Molecular imaging of retinal gliosis in transgenic mice induced by kainic acid neurotoxicity.
Topics: Animals; Brain Diseases; Diagnostic Imaging; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescence; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Mice; Mice, Transgenic; Neurotoxicity Syndromes; Ophthalmoscopes; Optic Nerve; Retinal Diseases | 2009 |
Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Inflammatory Agents; Blood-Brain Barrier; Calcium-Binding Proteins; Corticosterone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Microfilament Proteins; Neurotoxicity Syndromes; Time Factors | 2009 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines | 2010 |
The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity.
Topics: Adrenergic beta-3 Receptor Agonists; Animals; Anti-Inflammatory Agents; Apoptosis; Brain-Derived Neurotrophic Factor; Caspase 3; Clenbuterol; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Nerve Growth Factors; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2010 |
Toxic effects of domoic acid in the seabream Sparus aurata.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fish Diseases; Kainic Acid; Liver; Neurons; Neurotoxicity Syndromes; Receptors, Glutamate; Sea Bream | 2010 |
Increased expression of acyl-coenzyme A: cholesterol acyltransferase-1 and elevated cholesteryl esters in the hippocampus after excitotoxic injury.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cell Line, Transformed; Cholesterol; Cholesterol Esters; Disease Models, Animal; Excitatory Amino Acid Agonists; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Neurotoxicity Syndromes; Oligodendroglia; Rats; Rats, Wistar; RNA, Messenger; Sterol O-Acyltransferase | 2011 |
Selective blockade of A(2A) receptor protects against neurotoxicity induced by kainic acid in young rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Brain; Catalase; Glutathione Peroxidase; Glutathione Transferase; Kainic Acid; Male; Neurotoxicity Syndromes; Oxidative Stress; Pyrimidines; Rats; Reactive Oxygen Species; Seizures; Triazoles | 2012 |
Protective effect of 2,2'-dithienyl diselenide on kainic acid-induced neurotoxicity in rat hippocampus.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Glutathione Peroxidase; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Reaction Time; Seizures; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Thiophenes; Thymidine; Trityl Compounds | 2011 |
Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Kainic Acid; Male; Morpholines; Naphthalenes; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Seizures; Severity of Illness Index; Status Epilepticus | 2012 |
Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Male; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Spectrin; Ubiquitin Thiolesterase; Up-Regulation | 2012 |
Sex differences in effects of low level domoic acid exposure.
Topics: Animals; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Female; Glial Fibrillary Acidic Protein; Grooming; Hippocampus; Humans; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Male; Marine Toxins; Motor Activity; Neurotoxicity Syndromes; Olfactory Bulb; Phosphorylation; Rats; Rats, Sprague-Dawley; Risk Assessment; Severity of Illness Index; Sex Factors; Shellfish Poisoning; Stereotyped Behavior; Time Factors | 2013 |
Obesity exacerbates chemically induced neurodegeneration.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Dopamine; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Ion Channels; Kainic Acid; Membrane Transport Proteins; Methamphetamine; Mice; Mice, Obese; Microtubule-Associated Proteins; Mitochondrial Proteins; Neostriatum; Neurodegenerative Diseases; Neurons; Neurotoxicity Syndromes; Neurotoxins; Obesity; Presynaptic Terminals; Proteins; Uncoupling Protein 2 | 2002 |
Topiramate protects against glutamate- and kainate-induced neurotoxicity in primary neuronal-astroglial cultures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Calcium; Calcium Signaling; Cell Membrane; Cell Survival; Cells, Cultured; Fructose; Glutamic Acid; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Topiramate; Valproic Acid | 2003 |
Quantification and localization of kainic acid-induced neurotoxicity employing a new biomarker of cell death: cleaved microtubule-associated protein-tau (C-tau).
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Cell Death; Cerebrospinal Fluid; Dizocilpine Maleate; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Immunoblotting; Immunohistochemistry; Kainic Acid; Male; Microtubule Proteins; Microtubule-Associated Proteins; Neuregulin-1; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Silver Staining; Subarachnoid Hemorrhage; tau Proteins; Time Factors | 2003 |
Levetiracetam protects against kainic acid-induced toxicity.
Topics: Animals; Behavior, Animal; Brain; Cells, Cultured; Cerebral Cortex; Diencephalon; DNA Primers; Excitatory Amino Acid Agonists; Glutathione; Inflammation; Interleukin-1; Kainic Acid; Levetiracetam; Lipid Peroxidation; Macrophages; Male; Malondialdehyde; Neurons; Neurotoxicity Syndromes; Nootropic Agents; Piracetam; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA | 2004 |
Nutritional iron deprivation attenuates kainate-induced neurotoxicity in rats: implications for involvement of iron in neurodegeneration.
Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Behavior, Animal; Blood Glucose; Blood Proteins; Body Weight; Brain; Brain Chemistry; Cell Count; Dietary Supplements; Disease Models, Animal; Hematocrit; Immunohistochemistry; Iron; Iron Deficiencies; Kainic Acid; Male; Membrane Glycoproteins; Microglia; Nerve Degeneration; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Silver Staining; Zinc | 2004 |
Environmental and health effects associated with Harmful Algal Bloom and marine algal toxins in China.
Topics: Amnesia; Animals; China; Ciguatoxins; Diarrhea; Dinoflagellida; Environment; Eukaryota; Eutrophication; Fisheries; Food Contamination; Foodborne Diseases; Humans; Kainic Acid; Lethal Dose 50; Marine Toxins; Neurotoxicity Syndromes; Okadaic Acid; Oxocins; Paralysis; Seawater; Shellfish Poisoning | 2004 |
Inactivation of glycogen synthase kinase-3beta protects against kainic acid-induced neurotoxicity in vivo.
Topics: Animals; Behavior, Animal; Blotting, Western; Butadienes; Cell Death; Cell Survival; Cerebellum; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Kainic Acid; Lithium Chloride; Male; Mice; Mitogen-Activated Protein Kinase 1; Neurotoxicity Syndromes; Nitriles; Organ Culture Techniques; Phosphorylation; Serine; Tetrazolium Salts; Thiazoles; Time Factors; Tyrosine | 2004 |
Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum.
Topics: Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Kainic Acid; Male; Neurotoxicity Syndromes; Oxidopamine; Phencyclidine; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement Schedule | 2005 |
Estrogens influence behavioral responses in a kainic acid model of neurotoxicity.
Topics: Analysis of Variance; Animals; Brain Injuries; Estradiol; Exploratory Behavior; Female; Hippocampus; Kainic Acid; Maze Learning; Models, Animal; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Ovariectomy; Rats; Rats, Wistar; Recognition, Psychology; Space Perception | 2005 |
Behavioral and histopathological analysis of domoic Acid administration in marmosets.
Topics: Animals; Behavior, Animal; Brain; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Female; Follow-Up Studies; Injections, Intraperitoneal; Kainic Acid; Male; Motor Activity; Neurotoxicity Syndromes; Status Epilepticus | 2005 |
Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol.
Topics: alpha-Tocopherol; Animals; Brain; Docosahexaenoic Acids; F2-Isoprostanes; gamma-Tocopherol; Immunity, Innate; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes | 2005 |
Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.
Topics: Animals; Avoidance Learning; Behavior, Animal; Cell Count; Cell Death; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Pyruvates; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Non-invasive fluorescent imaging of gliosis in transgenic mice for profiling developmental neurotoxicity.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Western; Cerebral Ventricles; Diagnostic Imaging; Excitatory Amino Acid Agonists; Fluorescence; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Mice; Mice, Transgenic; Microscopy, Confocal; Neurotoxicity Syndromes; Neurotoxins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Death; Curcumin; Cyclooxygenase 2; Excitatory Amino Acid Agonists; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; Manganese; Neurons; Neurotoxicity Syndromes; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2007 |
Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-X Protein; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Gene Products, tat; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2008 |
Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glucose; Hydrogen Peroxide; Kainic Acid; Lipoxygenase Inhibitors; Mice; Mice, Inbred Strains; Microscopy, Phase-Contrast; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidants; Oxygen; Pyrazoles | 1999 |
Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment.
Topics: Aging; Animals; Brain Chemistry; Cell Count; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Lipid Peroxidation; Lipofuscin; Malondialdehyde; Mice; Mice, Inbred Strains; Microscopy, Electron; Nerve Tissue Proteins; Neurotoxicity Syndromes; Oxidative Stress; Seizures | 2002 |
Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebellar Cortex; Cyclin-Dependent Kinases; Enzyme Inhibitors; Kainic Acid; Mice; Neurotoxicity Syndromes; Protein Kinase Inhibitors; Receptors, Kainic Acid | 2002 |