kainic acid has been researched along with Disease Models, Animal in 1104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (5.25) | 18.7374 |
| 1990's | 86 (7.79) | 18.2507 |
| 2000's | 358 (32.43) | 29.6817 |
| 2010's | 504 (45.65) | 24.3611 |
| 2020's | 98 (8.88) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Braine, EL; Casillas-Espinosa, PM; Curl, CL; Delbridge, LM; Gomes, FM; Jones, NC; Liu, Z; Macefield, VG; O'Brien, TJ; Powell, KL; Raaijmakers, AJA; Sharma, P; Sivathamboo, S | 1 |
| Barker-Haliski, M; Knox, KM; White, HS; Zierath, DK | 1 |
| Cui, ZQ; He, RJ; Hou, GL; Luo, Y; Wang, YF; Yi, YL; Zhang, HY; Zhang, Y | 1 |
| Chen, Y; Liu, Q; Liu, Y; Tan, C; Wang, Y; Xu, T; Yang, J; Zhang, P | 1 |
| Drysdale, ND; Matthews, E; McNamara, JO; Pan, E; Schuetz, E | 1 |
| Boon, P; Carrette, E; Delbeke, J; Desloovere, J; Goossens, MG; Larsen, LE; Raedt, R; Vonck, K; Wadman, W | 1 |
| Adeyemi, OO; Afolayan, O; Ben-Azu, B; Ishola, IO; James, AB; Ojo, ES | 1 |
| Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS | 1 |
| Andersson, M; Gonzalez-Ramos, A; Kokaia, M; Kudláček, J; Ledri, M; Mikroulis, A; Waloschková, E | 1 |
| Li, L; Liu, X; Ma, L; Wang, L; Wang, T | 1 |
| Bleich, A; Buchecker, V; Koska, I; Pace, C; Palme, R; Potschka, H; Talbot, SR | 1 |
| Fernandez, AM; Grogan, DP; Gross, RE; Gutekunst, CA; Pedersen, NP | 1 |
| Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L | 1 |
| Liu, SY; Shen, KF; Wang, J; Wang, ZK; Wu, KF; Wu, ZF; Yang, H; Yang, XL; Yue, J; Zhang, CQ; Zhu, G | 1 |
| Audinat, E; Blaquiere, M; Canet, G; deBock, F; Desrumaux, C; Garcia, V; Givalois, L; Hernandez, C; Marchi, N; Moreno-Montano, M; Planel, E; Vitalis, M; Zub, E; Zussy, C | 1 |
| Haftcheshmeh, SM; Khamse, S; Momtazi-Borojeni, AA; Roghani, M; Sadr, SS; Suha, AJ | 1 |
| Baluchnejadmojarad, T; Hashemi, P; Nazari-Serenjeh, M; Ramazi, S; Roghani, M; Tashakori-Miyanroudi, M | 1 |
| Christian-Hinman, CA; Cutia, CA; Ge, X; Leverton, LK; Raetzman, LT; Youssef, R | 1 |
| Beck, J; Bock, HH; Freiman, TM; Jabbarli, R; Kleemann, T; Puhahn-Schmeiser, B | 1 |
| Baluchnejadmojarad, T; Fahanik-Babaei, J; Mohamadi-Zarch, SM; Ramazi, S; Roghani, M | 1 |
| Castillo, PE; Frechou, MA; Gonçalves, JT; Nasrallah, K; Persaud, S; Yoon, YJ | 1 |
| Duveau, V; Evrard, A; Gurrell, R; Iredale, P; Roucard, C; Ruggiero, C | 1 |
| Becker, AJ; Cases-Cunillera, S; Hamed, M; Müller, P; Opitz, T; Pitsch, J; Pohlentz, MS; Schoch, S; Surges, R; Vatter, H | 1 |
| Boitet, M; Eun, H; Grailhe, R; Kim, J; Lee, T | 1 |
| Behzadi, G; Davoudi, S; Hosseinmardi, N; Janahmadi, M; Khatibi, VA; Mirnajafi-Zadeh, J; Mohammadi, M; Nazari, M; Rahdar, M; Raoufy, MR; Rezaei, M | 1 |
| Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H | 1 |
| Antony, H; Audinat, E; Bedner, P; Breuer, A; Brosseron, F; Heneka, MT; Henning, L; Müller, J; Seifert, G; Singh, P; Steinhäuser, C | 1 |
| Anjum, A; Athi Kumar, RK; Cheah, YJ; Daud, MF; Idris, J; Ismail, OH; Lokanathan, Y; Mahadi, MK; Naicker, AS; Ng, MH; Tan, GC; Wong, YP; Yazid, MD | 1 |
| Babae, JF; Jogataei, MT; Mohammadi, E; Nikbakht, F; Vazifekhah, S | 1 |
| Babaei, JF; Hashemi, P; Nikbakht, F; Vazifekhah, S | 1 |
| Krook-Magnuson, E; Smith, MM; Stieve, BJ | 1 |
| Hu, D; Liu, J; Ma, Y; Tang, F; Yan, Y; Zhang, Z | 1 |
| Dahal, A; Govindarajan, K; Kar, S | 1 |
| Ahmadi, S; Hashemi, P | 1 |
| Hashemi, P; Izadpanah, E; Moloudi, MR; Vahabzadeh, Z | 1 |
| Chu, PC; Fisher, RS; Huang, CS; Ing, SZ; Liu, HL; Yu, HY | 1 |
| Chen, C; Dong, X; Fan, J; Gong, L; Huang, X; Jiang, J; Lin, D; Shen, W; Tang, Y; Wang, X; Xie, Y; Xu, A; Zeng, L; Zhang, X | 1 |
| Chen, Z; Cho, WS; Dai, SJ; Li, ZS; Nishibori, M; Park, SB; Qiu, XY; Shao, YY; Shi, JY; Sun, JY; Wang, Y; Xu, CL; Yan, MQ; Yi, S; Zheng, Y | 1 |
| Bowers, EK; Burbacher, T; Hendrix, AM; Lefebvre, KA; Marcinek, DJ; Stuppard, R | 1 |
| Fu, T; Kong, H; Wang, Y; Zhuo, Z | 1 |
| Geng, C; Li, A; Li, J; Liu, C; Liu, P; Wu, J; Zhu, Q | 1 |
| Kovac, S; Saadi, A; Sandouka, S; Shekh-Ahmad, T; Taiwo, RO | 1 |
| Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R | 1 |
| Avoli, M; Fisher, TAJ; Kennedy, TE; Lévesque, M; Wang, S | 1 |
| Lieb, A; Mutti, A; Schwarzer, C; Widmann, M | 1 |
| Boon, P; Carrette, E; Christiaen, E; Craey, E; Descamps, B; Goossens, MG; Larsen, LE; Raedt, R; Vanhove, C; Vonck, K | 1 |
| Auer, T; Erker, T; Schreppel, P; Schwarzer, C | 1 |
| Chetkovich, DM; Foote, KM; Han, Y; Heuermann, RJ; Lyman, KA; Mandikian, D; Michailidis, IE; Swanson, GT; Trimmer, JS | 1 |
| Binder, MS; Hodges, SL; Huebschman, JL; Lugo, JN; Nolan, SO; Okoh, JT; Reynolds, CD | 1 |
| Gupta, K; Schnell, E | 1 |
| Anjum, M; Brandt, C; Gericke, B; Hillmann, P; Kaczmarek, E; Löscher, W; Schidlitzki, A; Theilmann, W; Twele, F; Welzel, L | 1 |
| Gao, X; Li, S; Liu, Y; Pan, X; Sun, H; Wang, C; Wang, Q; Zhang, M; Zhang, X; Zhang, Y; Zhu, W | 1 |
| Chen, Y; Deng, J; Liu, X; Liu, Y; Ou, S; Tan, C; Wang, T; Xu, T; Yang, J; Yu, X; Yuan, J | 1 |
| Cui, Y; Gao, X; Pan, X; Sun, H; Wang, Q; Yu, J; Zhang, J; Zhang, M; Zhang, Y; Zhu, W | 1 |
| Deng, L; Liu, G; Lu, J; Yang, P; Zhou, N | 1 |
| Ba-M'hamed, S; Bennis, M; Bouchatta, O; Manouze, H; Sokar, Z | 1 |
| Biagini, G; Lukoyanov, NV; Rosal Lustosa, Í; Soares, JI | 1 |
| Anjum, M; Löscher, W; Schidlitzki, A; Twele, F; Welzel, L | 1 |
| He, Q; Kuang, S; Lan, H; Sun, J; Weng, N; Xue, H; Yang, H; Zhang, L | 1 |
| Berger, TC; Etholm, L; Heuser, K; Hjorthaug, HS; Nome, CG; Selmer, KK; Taubøll, E; Vigeland, MD | 1 |
| Chen, J; Chen, W; Li, L; Ma, Z; Wang, H; Yao, G | 1 |
| Ampig, K; Bui, AD; Ciernia, AV; Felong, S; Gschwind, T; Kim, HK; Nguyen, TM; Soltesz, I; Suh, D; Wood, MA | 1 |
| Dib, L; Fontana, A; Fritschy, JM; Gschwind, T; Lafourcade, C; Paterna, JC; Rambousek, L | 1 |
| Anderson, AE; Born, HA; Dao, AT; Lai, YC; Landstrom, AP; Larson, S; Lee, WL; Levine, AT; Wehrens, XH | 1 |
| Feria-Romero, I; Gallardo, JM; Guerra-Araiza, C; Guevara-Guzmán, R; Neri-Gomez, T; Orozco-Suarez, S; Rocha, L; Suárez-Santiago, JE; Vega-García, A | 1 |
| Inoue, T; Sada, N; Suto, S; Suzuki, M; Usui, S | 1 |
| Bahri, MA; Becker, G; Germonpré, C; Giacomelli, F; Lemaire, C; Luxen, A; Mievis, F; Plenevaux, A; Raedt, R; Rogister, B; Salmon, E; Seret, A; Serrano, ME | 1 |
| Dong, L; Hao, L; Shen, W; Wei, X; Yu, Q | 1 |
| Fox, P; Koh, S; Mithal, DS; Sanchez, RM; Somogyi, JR; Vien, AC | 1 |
| Cao, J; Gao, M; Rui, Y; Tang, C; Wang, L; Wang, Y; Xu, B; Yan, BC; Zhang, J | 1 |
| Biagini, G; Costa, AM; Lucchi, C; Rosal Lustosa, Í; Simonini, C | 1 |
| Baluchnejadmojarad, T; Fahanik-Babaei, J; Mohamadi-Zarch, SM; Nazari-Serenjeh, M; Nourabadi, D; Ramazi, S; Roghani, M; Tashakori-Miyanroudi, M | 1 |
| Chen, H; Cheng, L; Han, W; Jiang, L; Li, T; Liu, B; Liu, J; Song, X; Sun, H; Xie, L; Yang, C; Yang, J; Zhao, W | 1 |
| Alberch, J; Delgado-García, JM; Fernández-García, S; Giralt, A; Gruart, A; Hervé, D; Longueville, S; Sancho-Balsells, A | 1 |
| Bosco, DB; Li, Y; Richardson, JR; Wei, Y; Wu, LJ; Wu, W; Xie, M; Zhao, MG | 1 |
| Ali, MK; Alireza, MS; Babae, JF; Hashemi, P; Nikbakht, F; Vazifehkhah, S | 1 |
| Khanizadeh, AM; Mojarad, TB; Nikbakht, F; Vazifehkhah, S | 1 |
| Dong, X; Fan, M; Hao, X; Huang, X; Jiang, P; Wang, X; Xie, Y; Xu, P; Zeng, L | 1 |
| Chen, W; Dong, W; Guan, F; Ma, Y; Zhang, L; Zhang, X | 1 |
| Abou Jaoude, M; Azmi, A; Cash, SS; Coughlin, BF; Ebrahim, S; Fumeaux, NF; Kadambi, A; Kimchi, EY; Metcalf, CS; Moraes, MFD; Nagaraj, SB; Newell, TG; Thomson, KE; Wilcox, KS; Xu, JX | 1 |
| Fei, SJ; Miao, B; Su, Z; Xu, MQ; Yang, MJ; Zhang, JF | 1 |
| Batool, A; Bauer, S; Brennan, GP; Brindley, E; Connolly, NMC; Costard, LS; Del Gallo, F; Delanty, N; El-Naggar, H; Engel, T; Fabene, P; Heiland, M; Henshall, DC; Hill, TDM; Jimenez-Mateos, EM; Mamad, O; Mooney, C; Neubert, V; Norwood, B; Prehn, JHM; Raoof, R; Reschke, CR; Rosenow, F; Salvetti, B; Sanz-Rodriguez, A | 1 |
| Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH | 1 |
| He, H; Huang, Y; Lin, L; Pan, X; Wang, L; Wu, Y; Zhang, Y; Zhao, Y | 1 |
| Baluchnejadmojarad, T; Barati, H; Goudarzi, M; Jamali-Raeufy, N; Roghani, M | 1 |
| Anagnostou, I; Morales, T; Muñoz-Mayorga, D | 1 |
| Alalqam, R; Alves, M; Beamer, E; Conte, G; De Diego-Garcia, L; Engel, T; Henshall, DC; Lucas, JJ; Mendez, R; Ocampo, A; Ollà, I; Parras, A | 1 |
| Alves, M; Conte, G; Deussing, JM; Durner, A; Engel, T; Koch-Nolte, F; Kopp, R; Magnus, T; Nicke, A; Plesnila, N; Ramírez-Fernández, A; Rissiek, B; Scalbert, N; Urbina-Treviño, L; Zhang, J | 1 |
| Barbier, EL; Bretagnolle, L; Depaulis, A; Fauvelle, F; Guo, J; Hamelin, S; Labriji, W; Liu, C; Mazière, L; Parrot, S; Stupar, V | 1 |
| Bulska, E; Kaczmarek, L; Khomiak, D; Konopka, A; Pijet, B; Pikul, S; Rejmak, E; Stefaniuk, M | 1 |
| Aronica, E; Cattalini, A; de Curtis, M; Gnatkovsky, V; Pereira, MF; Testa, G; van Vliet, EA; Vila Verde, D; Zimmer, T | 1 |
| Kavaye Kandeda, A; Mbomo Ayissi, RE; Ngo Bum, E; Ojong, L; Okomolo Moto, FC; Omam Omam, JP | 1 |
| Baram, TZ; Chen, KD; Daglian, J; Garcia-Curran, MM; Hall, AM; Luo, R; Sanchez, GA | 1 |
| Gailus, B; Gericke, B; Hampel, P; Johne, M; Kaila, K; Käufer, C; Löscher, W; Römermann, K; Schidlitzki, A; Theilmann, W; Töllner, K; Vogel, A | 1 |
| Bergonzi, MC; Buonvicino, D; Landucci, E; Mazzantini, C; Pellegrini-Giampietro, DE | 1 |
| de Oliveira, DL; Dos Santos, TG; Linazzi, AM; Moro, L; Rech, G | 1 |
| Clement, EM; Greenfield, LJ; Kang, YJ; Lee, SH; Park, IH; Smith, BN | 1 |
| Bie, B; Chen, Y; Li, H; Li, J; Sheng, L; Wang, Z; Ye, J; You, H; Zhang, Q | 1 |
| Che, NW; Luan, ZL; Sun, XW; Wang, GY; Yan, DB; Yin, J; Zhang, C | 1 |
| Barker-Haliski, M; Knox, KM; Koneval, Z; Mizuno, S; White, HS; Zierath, DK | 1 |
| Guan, L; Li, H; Li, S; Li, X; Li, Y; Lin, J; Shi, Y; Yang, C; Zhang, Y | 1 |
| Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D | 1 |
| Carlson, S; Gregory-Flores, A; Hinojo-Perez, A; Olson, A; Sharma, S; Thippeswamy, T | 1 |
| Audinat, E; Bacigaluppi, M; Cerovic, M; Di Nunzio, M; Di Sapia, R; Gullotta, GS; Kebede, V; Marchi, N; Ravizza, T; Sorrentino, D; Vezzani, A | 1 |
| Binder, DK; Cullion, K; Garcia, TA; Pedapati, EV; Peterson, AR; Tiwari-Woodruff, SK | 1 |
| Beyeler, A; Dubanet, O; Ferreira Gomes Da Silva, A; Frick, A; Hirase, H; Leinekugel, X | 1 |
| Corinne, R; Venceslas, D | 1 |
| Andreev, GG; Georgiev, NG; Georgieva, KN; Hadjieva, MS; Shishmanova-Doseva, MS; Tchekalarova, JD; Terzieva, DD | 1 |
| Glauser, TA; Modi, AC; Rausch, JR; Steve White, H; Thomson, KE | 1 |
| Adongo, DW; Mante, PK; Woode, E | 1 |
| Andrade, PA; Lukoyanov, NV; Maia, GH; Soares, JI; Valente, MC | 1 |
| Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ | 1 |
| Chalif, JI; Drobac, E; Fletcher, EV; Mentis, GZ; Pagiazitis, JG; Simon, CM; Vukojicic, A; Wang, X | 1 |
| Bayat, A; Connell, P; Jahan, S; Joshi, S; Koubeissi, MZ; Mukharesh, L; Siddu, M; Skopin, MD; Tsuchiya, K; Younes, N | 1 |
| Guo, D; Wong, M; Zou, J | 1 |
| Anderson, AE; Davanger, S; Dosa, ZJ; Egbenya, DL; Hussain, S; Lai, YC; Sørensen, JB | 1 |
| Asahara, H; Fukaya, M; Hagiwara, M; Kobayashi, S; Komano-Inoue, S; Manabe, H; Manabe, T; Mizuguchi, M; Murakami, T; Ogonuki, N; Ogura, A; Okuda, K; Sakagami, H; Sato, T; Tanaka, T; Ueno, H; Watanabe, A; Yamaguchi, M | 1 |
| Brazete, CS; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI | 1 |
| Badia, A; Camps, P; Muñoz-Torrero, D; Pérez, B; Relat, J; Victòria Clos, M | 1 |
| Chen, L; Dong, J; Kai, J; Wang, Q; Wu, M; Zeng, LH; Zhu, F | 1 |
| Becker, A; Bedner, P; Deshpande, T; Henneberger, C; Herde, MK; Li, T; Schwarz, MK; Steinhäuser, C; Vatter, H | 1 |
| Gu, Q; Kanungo, J; Paule, MG; Raymick, J; Sarkar, S; Smani, D | 1 |
| Chi, Y; Guan, J; Guo, Y; Li, X; Lu, Z; Rao, J; Wu, B; Xiao, K; Xu, Q; Xu, Y; Xue, S | 1 |
| Davanger, S; Egbenya, DL; Hammer, J; Lorgen, JØ | 1 |
| Bordiga, P; Cassel, R; Chabbert, C; Hautefort, C; Pericat, D; Tighilet, B | 1 |
| Chen, YC; Du, TT; Jiang, Y; Liu, DF; Liu, YY; Shi, L; Wang, X; Zhang, JG; Zhang, X; Zhu, GY | 1 |
| Bankstahl, M; Brandt, C; Bröer, S; Gerhauser, I; Klee, R; Li, D; Löscher, W; Meller, S; Rankovic, V; Römermann, K; Schidlitzki, A; Töllner, K; Twele, F; Waltl, I | 1 |
| Baculis, BC; Chung, HJ; Jeong, HG; Lee, JH; Liu, DC; Pang, W; Tsai, NP; Weiss, AC | 1 |
| Kitchigina, VF; Matveeva, N; Mikheeva, IB; Pavlik, LL; Shubina, L | 1 |
| Arámburo, C; Ávila-Mendoza, J; Carranza, M; Fleming, T; Harvey, S; Luna, M; Martinez-Moreno, CG | 1 |
| Qi, X; Qiao, Z; Qu, Z; Su, F; Sun, J; Wang, H; Zhao, H; Zhu, Y | 1 |
| Tang, R; Tang, X; Yang, X; Yu, H | 1 |
| Li, Y; Lu, S; Lu, X; Ma, Y; Tian, X; Wang, W; Wang, X; Xu, D; Xu, X; Yang, Y; Zhang, Y; Zheng, F | 1 |
| Ji, Y; Jiang, N; Kuang, P; Lao, W; Lin, W; Wang, Z; Yin, T; Zhao, Y; Zhu, H | 1 |
| Acosta, ML; Kalloniatis, M; Khoo, P; Nivison-Smith, L | 1 |
| Li, Y; Liu, F; Lu, S; Tian, X; Wang, X; Xu, X; Yang, Q; Yang, Y; Zhang, Y; Zheng, F | 1 |
| Hartman, AL; Holden, K | 1 |
| Bertaso, F; deBock, F; Espallergues, J; Fayd'Herbe De Maudave, A; Ghosh, C; Girard, B; Guérineau, NC; Marchi, N; Milman, A; Pascussi, JM; Runtz, L; Toussenot, M | 1 |
| Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR | 1 |
| Bonnot, A; Cohen, I; Eugène, E; Sieu, LA | 1 |
| Bindila, L; Ellis, SR; Heeren, RMA; Lerner, R; Lutz, B; Post, JM; Vos, DRN | 1 |
| Atanasova, D; Atanassova, N; Ivanova, N; Lazarov, N; Nenchovska, Z; Pavlova, E; Tchekalarova, J | 1 |
| Huang, H; Lu, X; Luo, Z; Qiu, X; Tang, S; Xu, Z; Zhang, Y | 1 |
| Bragin, A; Engel, J; Kriukova, K; Li, L | 1 |
| Bankstahl, JP; Bankstahl, M; Bascuñana, P; Bengel, FM; Brackhan, M; Ross, TL | 1 |
| Naderali, E; Nikbakht, F; Ofogh, SN; Rasoolijazi, H | 1 |
| Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galati, C; Galli, F; Lattanzi, D; Minelli, A; Olivieri, F; Palma, E; Ruffolo, G; Saccomanno, S; Savelli, D; Torquato, P | 1 |
| Egert, U; Froriep, UP; Haas, CA; Häussler, U; Heining, K; Kilias, A | 1 |
| Chang, Y; Chen, YJ; Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Afonso, AR; Lukoyanov, NV; Maia, GH; Soares, JI | 1 |
| Abramov, AY; Dayalan Naidu, S; Dinkova-Kostova, AT; Eckel, R; Higgins, M; Kovac, S; Shekh-Ahmad, T; Walker, MC; Yamamoto, M | 1 |
| da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R | 1 |
| Cao, B; Chen, M; Dang, X; Han, S; Jia, C; Jiao, H; Liu, Y; Niu, Q; Wei, L | 1 |
| Chester, SJ; Goodkin, HP; Hawk, KM; Joshi, S; Rajasekaran, K | 1 |
| Ali, AB; Khalil, A; Khan, AA; Shekh-Ahmad, T; Walker, MC | 1 |
| Jia, YJ; Li, TR; Lv, RJ; Ma, C; Qiu, WY; Shao, XQ; Wang, Q | 1 |
| Chen, N; Ge, M; Han, CL; Hu, W; Li, L; Liu, YP; Meng, FG; Meng, WJ; Wang, KL; Zhang, JG; Zhao, XM | 1 |
| Banerjee, M; Hariharakrishnan, J; Kar, S; Kodam, A; Maulik, M; Ourdev, D; Wang, Y | 1 |
| Iqbal, R; Jain, GK; Siraj, F; Vohora, D | 1 |
| Boisgard, R; Bouilleret, V; Buvat, I; Caillé, F; Jego, B; Nguyen, DL; Pottier, G; Truillet, C; Wimberley, C | 1 |
| Chen, W; Dolce, A; Hartman, AL; Hoke, A; Santos, P | 1 |
| Gu, Y; Han, Z; Jiang, Z; Lin, Z; Lu, D; Ma, W; Meng, Y; Na, M; Song, Y; Tang, C; Wang, H; Wang, Y; Wu, H | 1 |
| Kaur, J; Nistri, A; Rauti, R | 1 |
| Fritz, KS; Gano, LB; Gomez, J; Liang, LP; Michel, CR; Patel, M; Reisdorph, N; Ryan, K; Vassilopoulos, A | 1 |
| Dong, D; Guo, SJ; Ruan, Y; Shen, DH; Wang, X; Zheng, XY; Zhu, J | 1 |
| Chen, GH; Chen, XY; Ma, YL; Shi, JH; Song, LF; Suo, JF; Wang, L | 1 |
| Blauwblomme, T; Capelle, L; Chever, O; Couillin, I; Dossi, E; Guinard, E; Huberfeld, G; Le Bert, M; Moulard, J; Pallud, J; Rouach, N; Vasile, F | 1 |
| Fritschy, JM; Gfeller, T; Gschwind, T; Knuesel, I; Lafourcade, C; Rambousek, L; Zaichuk, M | 1 |
| Dhir, A | 1 |
| Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H | 1 |
| Boylan, GB; Henshall, DC; Jimenez-Mateos, EM; Madden, SF; Molloy, EJ; Quinlan, SMM; Rodriguez-Alvarez, N | 1 |
| Jia, YJ; Li, TR; Lv, RJ; Shao, XQ; Wang, Q; Zhang, P | 1 |
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| Giordano, M; Hagenmeyer-Houser, SH; Sanberg, PR | 1 |
| Mares, P; Velísek, L; Velísková, J | 1 |
| Ashwood, TJ; Lancaster, B; Wheal, HV | 1 |
| Nauta, HJ; Pisharodi, M | 1 |
| Olney, JW | 1 |
| Kondo, S; Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Tanaka, S; Tanaka, T; Yonemasu, Y | 1 |
| Bartkowski, HM; Germano, IM; Meldrum, BS; Pitts, LH; Simon, RP | 1 |
| Hashizume, A; Lerner-Natoli, M; Rondouin, G | 1 |
| Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Makul'kin, RF; Rozhkov, VS; Shandra, AA | 1 |
| Björklund, A; Isacson, O; Sofroniew, MV | 1 |
| Onofrj, M; Pacifici, L; Pola, P; Ramacci, MT; Rossi, GF; Scerrati, M | 1 |
31 review(s) available for kainic acid and Disease Models, Animal
| Article | Year |
|---|---|
A Mesiotemporal Lobe Epilepsy Mouse Model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Sex Factors; Species Specificity | 2017 |
Curcumin in epilepsy disorders.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Brain; Curcuma; Curcumin; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Rats; Seizures | 2018 |
The kainic acid model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Humans; Kainic Acid | 2013 |
Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Nerve Net; Pilocarpine; Temporal Lobe | 2016 |
Chemically-induced TLE models: Topical application.
Topics: Administration, Topical; Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Nerve Net; Pilocarpine; Temporal Lobe | 2016 |
Perinatal Domoic Acid as a Neuroteratogen.
Topics: Animals; Brain; Disease Models, Animal; Humans; Kainic Acid; Neuromuscular Depolarizing Agents; Rats; Teratogens | 2016 |
Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 10; Nerve Degeneration | 2017 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds | 2010 |
Kainic acid-induced neurodegenerative model: potentials and limitations.
Topics: Animals; Disease Models, Animal; Kainic Acid; Neurodegenerative Diseases; Receptors, Kainic Acid; Signal Transduction | 2011 |
Neurological disease rises from ocean to bring model for human epilepsy to life.
Topics: Animals; DDT; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Marine Toxins; Neurotoxins; Pesticides; Water Pollutants, Chemical | 2010 |
Neuronal apoptosis after brief and prolonged seizures.
Topics: Animals; Apoptosis; Brain Damage, Chronic; Dentate Gyrus; Disease Models, Animal; Kainic Acid; Neurons; Pilocarpine; Rats; Seizures | 2002 |
Complications associated with genetic background effects in models of experimental epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Humans; Kainic Acid; Phenotype; Seizures; Species Specificity | 2002 |
Epilepsy-based changes in hippocampal excitability: causes and effects.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Nerve Net; Seizures; Synapses | 2006 |
Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsy.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Nerve Degeneration; Nerve Net; Neural Inhibition; Pyramidal Cells; Synapses | 2006 |
Histone modifications in status epilepticus induced by kainate.
Topics: Acetylation; Animals; Chromatin Assembly and Disassembly; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Histones; Humans; Kainic Acid; Phosphorylation; Receptors, Kainic Acid; Status Epilepticus; Transcription, Genetic | 2006 |
Safinamide: from molecular targets to a new anti-Parkinson drug.
Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbillinae; Humans; Kainic Acid; Levodopa; Mice; MPTP Poisoning; Neurons; Rats; Veratridine | 2006 |
Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures.
Topics: Animals; Animals, Newborn; Brain; Chlorides; Disease Models, Animal; Fluoresceins; Hippocampus; Homeostasis; K Cl- Cotransporters; Kainic Acid; Neurons; Organic Chemicals; Rats; Receptors, GABA-A; RNA, Messenger; Seizures; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Status Epilepticus; Symporters | 2007 |
Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis.
Topics: Animals; Biomarkers; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Humans; Kainic Acid; Models, Neurological; Monitoring, Physiologic; Rats; Seizures; Status Epilepticus; Telemetry; Time Factors; Videotape Recording | 2007 |
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Fever; Hippocampus; Hypoxia; Kainic Acid; Kindling, Neurologic; Pilocarpine; Rats; Recurrence; Seizures; Tetanus Toxin | 2007 |
[Animal models to develop surgery of focal epilepsies?].
Topics: Animals; Brain; Disease Models, Animal; Epilepsies, Partial; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Mice; Nerve Net; Neurosurgical Procedures | 2008 |
[Changes in spontaneous epileptic activity after selective intrahippocampal transection in a model of chronic mesial temporal lobe epilepsy].
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Kindling, Neurologic; Mice; Neuronal Plasticity; Neurosurgical Procedures | 2008 |
Neurotoxins as tools in neurobiology.
Topics: Animals; Brain; Disease Models, Animal; Elapid Venoms; Glutamates; Glutamic Acid; Humans; Hydroxydopamines; Kainic Acid; Nervous System Diseases; Neurons; Neurotoxins; Organ Specificity; Rats; Receptors, Neurotransmitter; Tetrodotoxin | 1981 |
[Toxic action of kainic acid as a model of Huntington chorea and epilepsy (review)].
Topics: Animals; Anticonvulsants; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Drug Interactions; gamma-Aminobutyric Acid; Hippocampus; Humans; Huntington Disease; Kainic Acid; Pyrrolidines; Rats; Seizures; Substantia Nigra | 1983 |
The relationships of aging changes in the basal ganglia to manifestations of Huntington's chorea.
Topics: Adenylyl Cyclases; Aging; Animals; Basal Ganglia; Cell Survival; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kainic Acid; Mice; Mice, Inbred CBA; Rats; Receptors, Dopamine; Species Specificity; Substantia Nigra | 1980 |
Epileptogenic effects of status epilepticus.
Topics: Animals; Brain; Brain Damage, Chronic; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Humans; Kainic Acid; Rats; Status Epilepticus | 1993 |
Kainate, a double agent that generates seizures: two decades of progress.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Neural Inhibition; Presynaptic Terminals; Pyramidal Cells; Receptors, Kainic Acid; Seizures; Synapses | 2000 |
Review: avian models for experimental myopia.
Topics: Animals; Chickens; Disease Models, Animal; Eyelids; Glaucoma; Hydrophthalmos; Kainic Acid; Light; Myopia; Quisqualic Acid; Retina; Vision, Ocular | 1991 |
[Model of choreic movement in monkey--contribution for understanding the mechanism of chorea in Huntington's disease].
Topics: Animals; Disease Models, Animal; Dopamine; Haplorhini; Huntington Disease; Kainic Acid; Levodopa | 1990 |
Neuropathology of excitatory neurotoxins: the domoic acid model.
Topics: Animals; Central Nervous System; Disease Models, Animal; Kainic Acid; Nervous System Diseases; Nervous System Neoplasms; Neuromuscular Depolarizing Agents; Neurotoxins | 1990 |
Experimental models of temporal lobe epilepsy: new insights from the study of kindling and synaptic reorganization.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Limbic System; Models, Neurological; Neural Pathways; Neuronal Plasticity; Sclerosis | 1990 |
Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.
Topics: Animals; Binding Sites; Brain; Calcium; Disease Models, Animal; Drug Interactions; Epilepsy, Temporal Lobe; Glucose; Glutamates; Glutamic Acid; Humans; Kainic Acid; Limbic System; Pyrrolidines; Status Epilepticus; Zinc | 1985 |
1 trial(s) available for kainic acid and Disease Models, Animal
| Article | Year |
|---|---|
Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: dose-dependent effects in the human photosensitivity model.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electroshock; Epilepsy, Reflex; Excitatory Amino Acid Agonists; Female; Humans; Kainic Acid; Male; Mice; Piperidines; Time Factors; Young Adult | 2013 |
1072 other study(ies) available for kainic acid and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Diastole; Disease Models, Animal; Echocardiography; Electrocardiography; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fibrosis; Heart Rate; Kainic Acid; Mitral Valve; Myocardium; Rats; Status Epilepticus; Sudden Unexpected Death in Epilepsy; Ventricular Dysfunction; Ventricular Remodeling; Video Recording | 2021 |
Continuous seizure emergency evoked in mice with pharmacological, electrographic, and pathological features distinct from status epilepticus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Emergencies; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Mice; Pentylenetetrazole; Seizures; Status Epilepticus | 2021 |
Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model.
Topics: Amygdala; Animals; Antioxidants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Methylene Blue; Mice; Neuroprotective Agents; Oxidative Stress; Status Epilepticus | 2021 |
G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Mice; Receptors, Metabotropic Glutamate | 2022 |
Intravenous kainic acid induces status epilepticus and late onset seizures in mice.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus | 2021 |
Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model.
Topics: Animals; Clozapine; Disease Models, Animal; Kainic Acid; Levetiracetam; Ligands; Mice; Seizures | 2022 |
Topics: Animals; Connaraceae; Disease Models, Animal; Epilepsy, Temporal Lobe; Genes, Immediate-Early; Humans; Kainic Acid; Mice; Plant Extracts | 2021 |
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microinjections; Seizures; Status Epilepticus | 2022 |
Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures.
Topics: Animals; Cells, Cultured; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Humans; Interneurons; Kainic Acid; Male; Rats; Recurrence; Seizures; Status Epilepticus; Stem Cell Transplantation; Stem Cells | 2021 |
Effects of perampanel on cognitive behavior and GluR1 expression in immature mice of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Morris Water Maze Test; Neurons; Nitriles; Pyridones; Receptors, AMPA; Transcription Factor AP-1 | 2022 |
Toward Evidence-Based Severity Assessment in Mouse Models with Repeated Seizures: (II.) Impact of Surgery and Intrahippocampal Kainate.
Topics: Animals; Corticosterone; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Seizures; Status Epilepticus | 2023 |
Loss of efferent projections of the hippocampal formation in the mouse intrahippocampal kainic acid model.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures | 2022 |
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.
Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory Disorders; Rats; Rats, Wistar; Seizures; Vitamin B Complex | 2022 |
Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fibroblast Growth Factors; Hippocampus; Kainic Acid; Mice; Seizures | 2022 |
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus | 2022 |
Ferulic Acid Attenuates Kainate-induced Neurodegeneration in a Rat Poststatus Epilepticus Model.
Topics: Animals; Coumaric Acids; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Nitrites; Rats; Rats, Wistar; Status Epilepticus | 2023 |
Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy.
Topics: Acetylcarnitine; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Rats; Seizures; Status Epilepticus | 2022 |
Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Phenotype; Seizures | 2022 |
Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Mice, Neurologic Mutants; Neurons | 2022 |
Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy.
Topics: Acetophenones; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice | 2022 |
Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy; Kainic Acid; Long-Term Potentiation; Mice; Mossy Fibers, Hippocampal; Seizures | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Seizures | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interleukin-1beta; Kainic Acid; Mice; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Pilocarpine; Seizures; Status Epilepticus | 2022 |
Non-invasive In Vivo Brain Astrogenesis and Astrogliosis Quantification Using a Far-red E2-Crimson Transgenic Reporter Mouse.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Longitudinal Studies; Mice; Mice, Transgenic | 2022 |
The Glycolysis Inhibitor 2-Deoxy-D-Glucose Exerts Different Neuronal Effects at Circuit and Cellular Levels, Partially Reverses Behavioral Alterations and does not Prevent NADPH Diaphorase Activity Reduction in the Intrahippocampal Kainic Acid Model of Te
Topics: Animals; Deoxyglucose; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Glucose; Glycolysis; Hippocampus; Kainic Acid; NADP; NADPH Dehydrogenase; Neurons | 2023 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2022 |
Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mice, Knockout; Microglia; Seizures; Status Epilepticus; Tumor Necrosis Factor-alpha | 2023 |
Protocol paper: kainic acid excitotoxicity-induced spinal cord injury paraplegia in Sprague-Dawley rats.
Topics: Animals; Disease Models, Animal; Humans; Kainic Acid; Paraplegia; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Spinal Injuries | 2022 |
Evaluation the cognition-improvement effects of N-acetyl cysteine in experimental temporal lobe epilepsy in rat.
Topics: Acetylcysteine; Animals; Cognition; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Maze Learning; Memory Disorders; Rats; TOR Serine-Threonine Kinases | 2023 |
Investigating the mechanism of antiepileptogenic effect of apigenin in kainate temporal lobe epilepsy: possible role of mTOR.
Topics: Animals; Apigenin; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mossy Fibers, Hippocampal; TOR Serine-Threonine Kinases | 2023 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Mice; Seizures | 2023 |
TMT-based proteomics profile reveals changes of the entorhinal cortex in a kainic acid model of epilepsy in mice.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Proteomics; Seizures; Tandem Mass Spectrometry | 2023 |
Administration of Kainic Acid Differentially Alters Astrocyte Markers and Transiently Enhanced Phospho-tau Level in Adult Rat Hippocampus.
Topics: Adult; Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Rats; Seizures; tau Proteins | 2023 |
Alpha-Pinene Exerts Antiseizure Effects by Preventing Oxidative Stress and Apoptosis in the Hippocampus in a Rat Model of Temporal Lobe Epilepsy Induced by Kainate.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Oxidative Stress; Rats; Rats, Wistar; Seizures | 2023 |
Anticonvulsant Effects of Royal Jelly in Kainic Acid-Induced Animal Model of Temporal Lobe Epilepsy Through Antioxidant Activity.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 2023 |
Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2023 |
Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Microglia; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2023 |
Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; HMGB Proteins; HMGB1 Protein; Kainic Acid; Mice | 2023 |
Age and Sex as Determinants of Acute Domoic Acid Toxicity in a Mouse Model.
Topics: Animals; Disease Models, Animal; Female; Kainic Acid; Male; Marine Toxins; Mice; Neurotoxins; Seizures | 2023 |
GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures.
Topics: Animals; Carrier Proteins; Cytokines; Disease Models, Animal; Epilepsy; Inflammasomes; Kainic Acid; Kruppel-Like Factor 4; Lipopolysaccharides; Mice; Microglia; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Seizures; Thioredoxins; Transcription Factors | 2023 |
Principal neurons in the olfactory cortex mediate bidirectional modulation of seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Neurons; Piriform Cortex; Seizures | 2023 |
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Neurons; Oxidative Stress; Rats; Reactive Oxygen Species; Seizures; Sestrins; Status Epilepticus; Transcription Factors | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizures; Zebrafish | 2023 |
CA3 principal cell activation triggers hypersynchronous-onset seizures in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Seizures; Status Epilepticus | 2023 |
Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Solvents | 2023 |
Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neural Pathways; Rats, Sprague-Dawley; Seizures | 2019 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2 | 2020 |
Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.
Topics: Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; HEK293 Cells; Humans; Ion Channel Gating; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Peroxins; Phosphorylation; Phosphoserine; Protein Subunits; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Conditioning, Classical; Disease Models, Animal; Fragile X Mental Retardation Protein; Kainic Acid; Male; Mice; Mice, Knockout; Motor Activity; Seizures; Social Behavior; Status Epilepticus | 2019 |
Neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Hippocampus; Humans; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Net; Wnt Proteins; Wnt Signaling Pathway | 2019 |
Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model.
Topics: Animals; Anxiety; Azabicyclo Compounds; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Seizures; Signal Transduction; Status Epilepticus; Triazines | 2020 |
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus.
Topics: Animals; Chondroitin Sulfates; Disease Models, Animal; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Imidazoles; Isoquinolines; Kainic Acid; Male; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Smad3 Protein; Status Epilepticus; Thrombospondin 1; Transforming Growth Factor beta1 | 2020 |
CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; MAP Kinase Signaling System; Mice; Neurons; Receptors, CXCR; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses | 2019 |
Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Mitochondria; Mitophagy; Pilocarpine; Rats; Reactive Oxygen Species; Status Epilepticus; Succinate Dehydrogenase; Succinic Acid | 2020 |
MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies.
Topics: Animals; Apoptosis; Cell Survival; Disease Models, Animal; Down-Regulation; Epilepsy; Gene Expression Regulation; HEK293 Cells; Hippocampus; Humans; Inflammation; Kainic Acid; Male; MAP Kinase Kinase 4; MicroRNAs; Neurons; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2019 |
Anticonvulsive and neuroprotective effects of aqueous and methanolic extracts of Anacyclus pyrethrum root in kainic acid-induced-status epilepticus in mice.
Topics: Animals; Anticonvulsants; Chrysanthemum cinerariifolium; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Methanol; Mice; Neuroprotective Agents; Plant Extracts | 2019 |
Neuroplasticity in Cholinergic Projections from the Basal Forebrain to the Basolateral Nucleus of the Amygdala in the Kainic Acid Model of Temporal Lobe Epilepsy.
Topics: Acetylcholine; Amygdala; Animals; Basal Forebrain; Cholinergic Neurons; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Neuronal Plasticity; Rats, Wistar; Vesicular Acetylcholine Transport Proteins | 2019 |
A face-to-face comparison of the intra-amygdala and intrahippocampal kainate mouse models of mesial temporal lobe epilepsy and their utility for testing novel therapies.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice | 2020 |
MicroRNA-451 Aggravates Kainic Acid-induced Seizure and Neuronal Apoptosis by Targeting GDNF.
Topics: Animals; Apoptosis; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; HEK293 Cells; Hippocampus; Humans; Kainic Acid; Mice; Mice, Knockout; MicroRNAs; Neurons; Seizures | 2020 |
Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis.
Topics: Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epilepsy, Temporal Lobe; Galanin; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genetic Predisposition to Disease; Histone Deacetylases; Kainic Acid; Male; Mice; Neuroglia; Neurons; Osteopontin; Receptors, Dopamine D1; Sequence Analysis, DNA; Sequence Analysis, RNA | 2019 |
LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway.
Topics: Animals; Astrocytes; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Genetic Vectors; Hippocampus; Janus Kinase 1; Kainic Acid; Male; Memory; Morris Water Maze Test; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Signal Transduction; STAT3 Transcription Factor | 2020 |
Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy.
Topics: Animals; Channelrhodopsins; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Interneurons; Kainic Acid; Mice; Optogenetics; Parvalbumins; Spatial Learning; Spatial Memory; Video Recording | 2020 |
Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Dentate Gyrus; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Kainic Acid; Male; Mice | 2020 |
Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.
Topics: Animals; Arrhythmias, Cardiac; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Mice; Status Epilepticus | 2020 |
Magnolia officinalis Reduces Inflammation and Damage Induced by Recurrent Status Epilepticus in Immature Rats.
Topics: Animals; Disease Models, Animal; Hippocampus; Inflammation; Kainic Acid; Magnolia; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2020 |
Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.
Topics: Animals; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intraventricular; Kainic Acid; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred ICR; Seizures; Up-Regulation | 2020 |
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Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Magnetic Resonance Imaging; Membrane Glycoproteins; Nerve Tissue Proteins; Positron-Emission Tomography; Pyridines; Pyrrolidinones; Rats, Sprague-Dawley | 2020 |
Edaravone inhibits procaspase-3 denitrosylation and activation through FasL-Trx2 pathway in KA-induced seizure.
Topics: Animals; Caspase 3; Disease Models, Animal; Edaravone; Fas Ligand Protein; Kainic Acid; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Specific Pathogen-Free Organisms | 2020 |
Dexamethasone after early-life seizures attenuates increased susceptibility to seizures, seizure-induced microglia activation and neuronal injury later in life.
Topics: Animals; Dexamethasone; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Macrophage Activation; Male; Microglia; Neurons; Rats, Long-Evans; Seizures | 2020 |
Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy.
Topics: Animals; Antioxidants; Autophagosomes; Autophagy; Autophagy-Related Proteins; CA3 Region, Hippocampal; Disease Models, Animal; DNA-Binding Proteins; Kainic Acid; Male; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Quercetin; Seizures; Signal Transduction | 2020 |
Status Epilepticus Dynamics Predicts Latency to Spontaneous Seizures in the Kainic Acid Model.
Topics: Animals; Brain; Cell Death; Cell Survival; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Gamma Rhythm; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Theta Rhythm | 2020 |
Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy: Involvement of oxidative stress, inflammation and pyroptosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Male; Morphinans; Neuroprotective Agents; Oxidative Stress; Pyroptosis; Rats; Reactive Oxygen Species | 2020 |
Dynamic alteration of dendrites and dendritic spines in the hippocampus and microglia in mouse brain tissues after kainate-induced status epilepticus.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Dendrites; Dendritic Spines; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Mice; Microglia; Pyramidal Cells; Status Epilepticus | 2021 |
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Deletion; Hippocampus; Kainic Acid; Lithium; Locomotion; Mice, Inbred C57BL; Neurons; Neuroprotection; Phenotype; Pilocarpine; Receptor, trkB; Severity of Illness Index; Spatial Learning | 2020 |
Microglial depletion aggravates the severity of acute and chronic seizures in mice.
Topics: Animals; Disease Models, Animal; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; Microglia; Seizures; Status Epilepticus | 2020 |
Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Metformin; Neurons; Rats; Rats, Wistar | 2020 |
The possible role of progranulin on anti-inflammatory effects of metformin in temporal lobe epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Kainic Acid; Metformin; Progranulins; Rats | 2020 |
RNA sequencing analysis of cortex and hippocampus in a kainic acid rat model of temporal lobe epilepsy to identify mechanisms and therapeutic targets related to inflammation, immunity and cognition.
Topics: Animals; Cerebral Cortex; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Immunity; Inflammation; Kainic Acid; Male; Rats, Sprague-Dawley; Sequence Analysis, RNA; Transcriptome | 2020 |
Ablation of C9orf72 together with excitotoxicity induces ALS in rats.
Topics: Amyotrophic Lateral Sclerosis; Animals; C9orf72 Protein; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation; Gene-Environment Interaction; Golgi Apparatus; Humans; Kainic Acid; Male; Motor Neurons; Nerve Tissue Proteins; Neurogenesis; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Spleen; Transport Vesicles | 2021 |
Accurate detection of spontaneous seizures using a generalized linear model with external validation.
Topics: Animals; Area Under Curve; Disease Models, Animal; Electrocorticography; Electroencephalography; Epilepsies, Partial; Excitatory Amino Acid Agonists; Kainic Acid; Linear Models; Machine Learning; Rats; Reproducibility of Results; ROC Curve; Seizures; Signal Processing, Computer-Assisted | 2020 |
Protective effect of microinjection of glutamate into hypothalamus paraventricular nucleus on chronic visceral hypersensitivity in rats.
Topics: Animals; Arginine Vasopressin; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Kainic Acid; Male; Microinjections; Pain Threshold; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Vagus Nerve; Visceral Pain | 2020 |
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Circulating MicroRNA; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Muscarinic Agonists; Perforant Pathway; Pilocarpine; Rats | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flurothyl; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenotype; Quantitative Trait Loci; Seizures; Sudden Unexpected Death in Epilepsy; Whole Genome Sequencing | 2020 |
Adipose-derived stem cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Learning; Male; Maze Learning; Memory; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nerve Growth Factors; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
Combination therapy with dipeptidyl peptidase-4 and P2X7 purinoceptor inhibitors gives rise to antiepileptic effects in rats.
Topics: Animals; Anticonvulsants; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; DNA Fragmentation; Drug Therapy, Combination; Electroencephalography; Epilepsy; Gliosis; Hippocampus; Kainic Acid; Linagliptin; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Rosaniline Dyes; Seizures; Treatment Outcome | 2020 |
Prolactin neuroprotective action against excitotoxic insult in the hippocampus of male mice.
Topics: Animals; Brain Injuries; Cell Death; Disease Models, Animal; Hippocampus; Humans; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Neurotoxins; Prolactin; Rats | 2021 |
High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Status Epilepticus; Transcriptome | 2020 |
Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model.
Topics: Animals; Chromosomes, Artificial, Bacterial; Disease Models, Animal; Female; Genes, Reporter; Green Fluorescent Proteins; Kainic Acid; Male; Mice; Mice, Transgenic; Neurons; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Status Epilepticus | 2020 |
In vivo γ-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrophoresis, Capillary; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolomics; Mice; Multivariate Analysis; Proton Magnetic Resonance Spectroscopy; Sclerosis | 2021 |
The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Drug Evaluation, Preclinical; Hydroxamic Acids; Kainic Acid; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice, Inbred C57BL; Nectins; Status Epilepticus | 2020 |
Seizure activity and brain damage in a model of focal non-convulsive status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Guinea Pigs; Kainic Acid; Seizures; Status Epilepticus | 2021 |
Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Cameroon; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice | 2021 |
Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Agonists; Female; Hippocampus; Hot Temperature; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures, Febrile; Status Epilepticus; Translational Research, Biomedical | 2021 |
Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Solute Carrier Family 12, Member 2 | 2021 |
Neuroprotective Effects of Thymoquinone by the Modulation of ER Stress and Apoptotic Pathway in In Vitro Model of Excitotoxicity.
Topics: Animals; Apoptosis; Benzoquinones; CA3 Region, Hippocampal; Disease Models, Animal; Disks Large Homolog 4 Protein; Endoplasmic Reticulum Stress; Epilepsy; Excitatory Amino Acid Agonists; Female; In Vitro Techniques; Kainic Acid; Male; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar | 2021 |
An optimized method for adult zebrafish brain-tissue dissociation that allows access mitochondrial function under healthy and epileptic conditions.
Topics: Animals; Brain; Cell Respiration; Disease Models, Animal; Energy Metabolism; Epilepsy; Female; Histocytological Preparation Techniques; Kainic Acid; Male; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Pentylenetetrazole; Tissue Preservation; Zebrafish | 2021 |
Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABAergic Neurons; Gene Expression; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2021 |
Vagus nerve stimulation affects inflammatory response and anti-apoptosis reactions via regulating miR-210 in epilepsy rat model.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Male; MicroRNAs; Rats; Rats, Sprague-Dawley; Vagus Nerve Stimulation | 2021 |
Inhibition of microRNA-129-2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; MicroRNAs; Rats; Receptors, GABA-A; Seizures | 2021 |
Diurnal burden of spontaneous seizures in early epileptogenesis in the post-kainic acid rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
Abnormal neuronal damage and inflammation in the hippocampus of kainic acid-induced epilepsy mice.
Topics: Animals; Disease Models, Animal; Doublecortin Protein; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons | 2021 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Compounding; Drug Discovery; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Temporal Lobe; Everolimus; High-Throughput Screening Assays; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Seizures; Translational Research, Biomedical | 2021 |
Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy.
Topics: Animals; Benzodioxoles; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Inflammation Mediators; Kainic Acid; Male; Proto-Oncogene Proteins c-fyn; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Telemetry | 2021 |
Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kainic Acid; Male; Mice; Microglia; Seizures; Status Epilepticus | 2021 |
Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Gene Knock-In Techniques; Hippocampus; Kainic Acid; Mice; Seizures; Up-Regulation | 2021 |
Probing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo.
Topics: Action Potentials; Acute Disease; Animals; CA3 Region, Hippocampal; Disease Models, Animal; GABAergic Neurons; Gene Silencing; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Male; Mice; Optogenetics; Parvalbumins; Pyramidal Cells; Seizures; Synaptic Transmission; Time Factors | 2021 |
Effect of Training at Lactate Threshold Intensity on Maximal Time to Exhaustion, Depression and Anxiety Behaviour of Spontaneously Hypertensive Rats after Kainate-Induced Status Epilepticus.
Topics: Animals; Anxiety; Behavior, Animal; Comorbidity; Depression; Disease Models, Animal; Essential Hypertension; Excitatory Amino Acid Agonists; Fatigue; Heart Rate; Hypertension; Impulsive Behavior; Kainic Acid; Lactic Acid; Male; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Status Epilepticus; Time Factors | 2017 |
The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Medication Adherence; Rats; Rats, Sprague-Dawley | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nifedipine; Pentylenetetrazole; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley | 2017 |
Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy.
Topics: Analysis of Variance; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Septum of Brain; Vesicular Acetylcholine Transport Proteins | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Injections, Intraventricular; Kainic Acid; Mice, Inbred C57BL; Pentylenetetrazole; Pilocarpine; Pyramidal Cells; Severity of Illness Index; Triterpenes; Zebrafish | 2017 |
Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.
Topics: Action Potentials; Animals; Cell Survival; Disease Models, Animal; Kainic Acid; Metalloendopeptidases; Mice; Mice, Transgenic; Motor Neurons; Muscular Atrophy, Spinal; Neuromuscular Junction; Proprioception; Reflex, Righting; Shab Potassium Channels; Survival of Motor Neuron 1 Protein; Survival of Motor Neuron 2 Protein; Synapses; Tetanus Toxin | 2017 |
Effects of low-frequency electrical stimulation of the anterior piriform cortex on kainate-induced seizures in rats.
Topics: Animals; Deep Brain Stimulation; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Male; Piriform Cortex; Rats; Rats, Sprague-Dawley; Seizures | 2017 |
Rapamycin Attenuates Acute Seizure-induced Astrocyte Injury in Mice in Vivo.
Topics: Animals; Astrocytes; Disease Models, Animal; Kainic Acid; Mice; Seizures; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Vacuoles | 2017 |
The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines.
Topics: Animals; Cells, Cultured; Chronic Disease; Cytoplasmic Vesicles; Dendritic Spines; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice, Knockout; Microscopy, Electron; Post-Synaptic Density; Presynaptic Terminals; Rats, Sprague-Dawley; Rats, Wistar; Synaptotagmin I | 2017 |
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Antagonists; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Piperidines; Post-Synaptic Density; Protein Serine-Threonine Kinases; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Tissue Culture Techniques | 2017 |
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Fenclonine; Hippocampus; Kainic Acid; Male; Maze Learning; Memory Disorders; Neurons; Rats, Wistar; Seizures; Serotonin; Spatial Memory | 2017 |
Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation.
Topics: Aminoquinolines; Animals; Apoptosis; Biomarkers; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Encephalitis; Heterocyclic Compounds, 4 or More Rings; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neuronal Plasticity; Neuroprotective Agents; Neurotoxicity Syndromes | 2018 |
Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Neurons; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2018 |
Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy.
Topics: Animals; Antigens; Astrocytes; Cell Membrane; Connexin 30; Connexin 43; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Kainic Acid; Male; Mice; Mice, Transgenic; Platelet Endothelial Cell Adhesion Molecule-1; Proteoglycans; S100 Calcium Binding Protein beta Subunit; Subcellular Fractions; Up-Regulation | 2017 |
Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model.
Topics: 14-3-3 Proteins; Animals; Disease Models, Animal; Down-Regulation; Frontal Lobe; Kainic Acid; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley | 2018 |
Establishment of a rhesus monkey model of chronic temporal lobe epilepsy using repetitive unilateral intra-amygdala kainic acid injections.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Gliosis; Infusion Pumps, Implantable; Kainic Acid; Macaca mulatta; Male; Neurosurgical Procedures; Pyramidal Cells; Seizures; Temporal Lobe | 2017 |
PICK1 facilitates lasting reduction in GluA2 concentration in the hippocampus during chronic epilepsy.
Topics: Animals; Blotting, Western; Carrier Proteins; Chronic Disease; Cytoskeletal Proteins; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Kainic Acid; Male; Multivariate Analysis; Neurons; Nuclear Proteins; Rats, Wistar; Receptors, AMPA; Regression Analysis; Tubulin | 2017 |
New mouse model for inducing and evaluating unilateral vestibular deafferentation syndrome.
Topics: Animals; Disease Models, Animal; Female; Functional Laterality; Kainic Acid; Male; Mice, Inbred C57BL; Motor Activity; Postural Balance; Vestibular Diseases; Vestibule, Labyrinth | 2018 |
Anterior thalamic nuclei deep brain stimulation reduces disruption of the blood-brain barrier, albumin extravasation, inflammation and apoptosis in kainic acid-induced epileptic rats.
Topics: Albumins; Animals; Anterior Thalamic Nuclei; Apoptosis; Blood-Brain Barrier; Capillary Permeability; Deep Brain Stimulation; Disease Models, Animal; Epilepsy; Inflammation; Kainic Acid; Male; Random Allocation; Rats, Sprague-Dawley | 2017 |
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Mice; Neurons; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors; Treatment Outcome | 2017 |
Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
Topics: Animals; Atrophy; Caspase 3; Cells, Cultured; Disease Models, Animal; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hippocampus; Humans; Kainic Acid; Male; Neurons; Potassium Channels, Inwardly Rectifying; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2017 |
Fatty acid amide hydrolase inhibitor URB597 may protect against kainic acid-induced damage to hippocampal neurons: Dependence on the degree of injury.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Cell Death; Cell Nucleus; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum; Enzyme Inhibitors; Hippocampus; Kainic Acid; Microscopy, Electron; Mitochondria; Neurons; Neuroprotective Agents; Rats, Wistar; Severity of Illness Index; Status Epilepticus | 2017 |
Growth hormone protects against kainate excitotoxicity and induces BDNF and NT3 expression in chicken neuroretinal cells.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Chickens; Disease Models, Animal; Excitatory Amino Acid Agonists; Growth Hormone; Kainic Acid; Neuroprotection; Neuroprotective Agents; Neurotrophin 3; Retina; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Wnt/β-catenin signalling pathway mediated aberrant hippocampal neurogenesis in kainic acid-induced epilepsy.
Topics: Animals; beta Catenin; Cyclin D1; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Up-Regulation; Wnt Signaling Pathway; Wnt3A Protein | 2017 |
Effects of spontaneous recurrent seizures on cognitive function via modulation of SNAREs expression.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Escape Reaction; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Locomotion; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Seizures; SNARE Proteins; Synapses; Synaptosomal-Associated Protein 25; Synaptotagmin I; Valproic Acid; Vesicle-Associated Membrane Protein 2 | 2018 |
POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Gene Knockdown Techniques; Hippocampus; Humans; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Ubiquitin-Protein Ligases; Young Adult | 2017 |
Anticonvulsant effect of gentamicin on the seizures induced by kainic acid.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gentamicins; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Valproic Acid | 2018 |
Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia.
Topics: Animals; Calbindin 2; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Ischemia; Kainic Acid; Neuroprotective Agents; Parvalbumins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Neurons; Retinal Vessels; Vinca Alkaloids | 2018 |
CD36 Deficiency Suppresses Epileptic Seizures.
Topics: Action Potentials; Analysis of Variance; Animals; CD36 Antigens; Convulsants; Disease Models, Animal; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Seizures | 2017 |
d-Leucine: Evaluation in an epilepsy model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Leucine; Male; Mice; Photoperiod; Status Epilepticus | 2018 |
Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
Topics: Animals; Calcium-Binding Proteins; Constitutive Androstane Receptor; Corticosterone; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Routes; Excitatory Amino Acid Agonists; Functional Laterality; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microsomes, Liver; Receptors, Cytoplasmic and Nuclear; Recurrence; RNA, Messenger; Statistics, Nonparametric; Status Epilepticus; Time Factors | 2018 |
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Topics: Animals; Brain; Brain Waves; Carbamates; Cognition Disorders; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Electroencephalography; Excitatory Amino Acid Agonists; Fluoresceins; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monoacylglycerol Lipases; Neurons; Piperidines; Random Allocation; Receptor, Cannabinoid, CB1; Recognition, Psychology; Status Epilepticus; Sulfonamides; Time Factors | 2018 |
Disrupted Co-activation of Interneurons and Hippocampal Network after Focal Kainate Lesion.
Topics: Action Potentials; Animals; Cell Count; Cell Membrane; Cell Size; Disease Models, Animal; Electric Capacitance; Electric Impedance; Epilepsy; Green Fluorescent Proteins; Hippocampus; Interneurons; Kainic Acid; Male; Mice, Transgenic; Neural Pathways; Patch-Clamp Techniques; Tissue Culture Techniques | 2017 |
Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls.
Topics: Acute Disease; Animals; Brain; Disease Models, Animal; Gene Expression Profiling; Kainic Acid; Lipids; Mice; Seizures | 2018 |
Losartan suppresses the kainate-induced changes of angiotensin AT
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Blood Pressure; Comorbidity; Disease Models, Animal; Epilepsy; Gene Expression; Hippocampus; Hypertension; Kainic Acid; Limbic System; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2018 |
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy.
Topics: Adult; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Growth Hormone-Releasing Hormone; Hippocampus; Humans; Kainic Acid; Male; Mice; Middle Aged; Neurons; Pentylenetetrazole; Receptors, GABA-A; Synapses; Young Adult | 2017 |
Seizure development in the acute intrahippocampal epileptic focus.
Topics: Animals; Disease Models, Animal; Electrophysiological Phenomena; Hippocampus; Humans; Kainic Acid; Male; Rats; Seizures | 2018 |
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Topics: Animals; Carbazoles; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorine Radioisotopes; Hippocampus; Kainic Acid; Male; Mice; Positron-Emission Tomography | 2018 |
The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Hippocampus; Kainic Acid; Learning Disabilities; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Plant Extracts; Rats; Rats, Wistar; Rosmarinus; Time Factors | 2018 |
Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Tocopherol; Animals; Blood-Brain Barrier; Disease Models, Animal; Gene Expression Regulation; Inflammation; Kainic Acid; Male; MicroRNAs; Nerve Degeneration; Oocytes; Oxidative Stress; Rats, Sprague-Dawley; Receptors, GABA; Seizures; Status Epilepticus; Xenopus | 2018 |
Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Theta Rhythm | 2018 |
Astaxanthin protects against kainic acid-induced seizures and pathological consequences.
Topics: Animals; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Seizures; Xanthophylls | 2018 |
The pedunculopontine and laterodorsal tegmental nuclei in the kainate model of epilepsy.
Topics: Animals; Cell Count; Cholinergic Fibers; Cholinergic Neurons; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Neural Pathways; Pedunculopontine Tegmental Nucleus; Rats; Rats, Wistar; Tegmentum Mesencephali | 2018 |
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutathione; Kainic Acid; Kelch-Like ECH-Associated Protein 1; Male; Membrane Potential, Mitochondrial; Mice, Transgenic; Mutation; Neuroglia; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Triterpenes | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Kainic Acid; Male; Malondialdehyde; Maze Learning; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Phenytoin; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Seizures; Sesquiterpenes; Status Epilepticus | 2018 |
Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; CA3 Region, Hippocampal; Camphanes; Carbamazepine; Cognition; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy, Combination; Drugs, Chinese Herbal; Epilepsy, Temporal Lobe; Escape Reaction; Glial Cell Line-Derived Neurotrophic Factor; Kainic Acid; Male; Maze Learning; Panax notoginseng; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Reaction Time; Salvia miltiorrhiza; Time Factors | 2018 |
Status epilepticus: Role for etiology in determining response to benzodiazepines.
Topics: Animals; Benzodiazepines; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; Gene Expression Regulation; Hippocampus; Kainic Acid; Lipoproteins; Lithium Chloride; Male; Phosphorylation; Pilocarpine; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Shal Potassium Channels; Statistics, Nonparametric; Status Epilepticus; Time Factors | 2018 |
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model.
Topics: Administration, Oral; Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 2018 |
The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.
Topics: Animals; Case-Control Studies; Cell Line; Chronic Disease; Complement Factor H; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Gene Knockdown Techniques; Hippocampus; Humans; Inflammation; Interleukin-1beta; Kainic Acid; Male; MicroRNAs; Rats, Sprague-Dawley; Up-Regulation | 2018 |
LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy.
Topics: Animals; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Janus Kinases; Kainic Acid; Male; Neuroglia; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Signal Transduction; STAT Transcription Factors; Transduction, Genetic | 2018 |
A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2019 |
Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice.
Topics: Animals; Anticonvulsants; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Hippocampus; Kainic Acid; Letrozole; Male; Mice; Random Allocation; Seizures; Testosterone | 2018 |
Longitudinal positron emission tomography imaging of glial cell activation in a mouse model of mesial temporal lobe epilepsy: Toward identification of optimal treatment windows.
Topics: Animals; Autoradiography; CD11b Antigen; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluorodeoxyglucose F18; Glial Fibrillary Acidic Protein; In Vitro Techniques; Kainic Acid; Longitudinal Studies; Male; Mice; Mice, Inbred C57BL; Neuroglia; Platelet Endothelial Cell Adhesion Molecule-1; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Receptors, GABA; Statistics, Nonparametric; Time Factors; Tomography Scanners, X-Ray Computed | 2018 |
Different ketogenesis strategies lead to disparate seizure outcomes.
Topics: Animals; Blood Glucose; Body Weight; Brain; Diet, Ketogenic; Disease Models, Animal; Electric Stimulation; Fasting; Kainic Acid; Ketosis; Male; Mice; Mitochondria; Random Allocation; Seizures; Treatment Outcome | 2018 |
Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR.
Topics: Animals; Antagomirs; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Maze Learning; MicroRNAs; PTEN Phosphohydrolase; Rats; Rats, Wistar; Statistics, Nonparametric; Status Epilepticus; Time Factors; TOR Serine-Threonine Kinases | 2018 |
Nicotine-mediated neuroprotection of rat spinal networks against excitotoxicity.
Topics: Animals; Central Pattern Generators; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Motor Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Reflex; Spinal Cord; Spinal Injuries | 2018 |
Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.
Topics: Acetylation; Animals; Disease Models, Animal; Energy Metabolism; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mitochondria; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Sirtuins | 2018 |
Kainic Acid Impairs the Memory Behavior of APP23 Mice by Increasing Brain Amyloid Load through a Tumor Necrosis Factor-α-Dependent Mechanism.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation; Kainic Acid; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Oligopeptides; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
MiR-181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Epilepsy; Female; Hippocampus; Kainic Acid; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; MicroRNAs; Neuroprotection; p38 Mitogen-Activated Protein Kinases; Random Allocation; Rats, Wistar; Toll-Like Receptor 4 | 2019 |
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mefloquine; Mice; Nerve Tissue Proteins; Probenecid; Seizures; Signal Transduction | 2018 |
Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; Neuronal Plasticity; Seizures; Status Epilepticus | 2018 |
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; Kainic Acid; Male; Mice; Pilocarpine; Seizures | 2019 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Seizures | 2018 |
Correlation between tumor necrosis factor alpha mRNA and microRNA-155 expression in rat models and patients with temporal lobe epilepsy.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Gene Expression; Hippocampus; Humans; Kainic Acid; Male; MicroRNAs; Middle Aged; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Specific Pathogen-Free Organisms; Status Epilepticus; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mice, Inbred C57BL; Neurons; Seizures | 2018 |
Anterior nucleus of thalamus stimulation inhibited abnormal mossy fiber sprouting in kainic acid-induced epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cell Nucleus; Deep Brain Stimulation; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Seizures; Semaphorin-3A | 2018 |
Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Curcumin; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; Hippocampus; Inflammation; Interleukin-1beta; Kainic Acid; Male; Maze Learning; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley | 2018 |
Topics: Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Kainic Acid; Magnesium; Male; Memory Disorders; Mice; Mice, Inbred BALB C; Nerve Net; Prognosis; Random Allocation; Severity of Illness Index; Temporal Lobe; Treatment Outcome | 2018 |
The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Maze Learning; Mice, Inbred C57BL; Space Perception; Spatial Learning; Spatial Memory | 2019 |
Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets.
Topics: Animals; Anticonvulsants; Cell Death; Computational Biology; Computer Simulation; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; MicroRNAs; Neuroglia; Status Epilepticus | 2018 |
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Administration, Oral; Animals; Anticonvulsants; Citrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fruit; Hesperidin; Kainic Acid; Male; Mice; Phytotherapy | 2018 |
Lacosamide modulates collapsin response mediator protein 2 and inhibits mossy fiber sprouting after kainic acid-induced status epilepticus.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Fluoresceins; Intercellular Signaling Peptides and Proteins; Kainic Acid; Lacosamide; Male; Mice; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Rats, Wistar; Status Epilepticus; Time Factors | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epilepsy; Humans; Kainic Acid; Mice; Pentylenetetrazole; Pilocarpine; Saccharomyces cerevisiae | 2018 |
Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.
Topics: Animals; Brain; Cistanche; Cytokines; Disease Models, Animal; Epilepsy; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Glycosides; Inflammation; Kainic Acid; Male; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2018 |
RASgrf1, a Potential Methylatic Mediator of Anti-epileptogenesis?
Topics: Animals; Disease Models, Animal; DNA Methylation; Electroencephalography; Gene Expression; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Phthalimides; Promoter Regions, Genetic; ras-GRF1; Status Epilepticus; Tryptophan | 2018 |
Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Reaction Time; Receptor, Galanin, Type 2; Receptor, Galanin, Type 3; Seizures | 2018 |
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis.
Topics: Animals; Anticonvulsants; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; CD11b Antigen; Cytokines; Dinoprostone; Disease Models, Animal; Docosahexaenoic Acids; Encephalitis; Epilepsy; Gene Expression Regulation; Hippocampus; Kainic Acid; Leukotriene B4; Lipid Metabolism; Lipoxins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2018 |
Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin | 2018 |
Acid reflux induced laryngospasm as a potential mechanism of sudden death in epilepsy.
Topics: Animals; Death, Sudden; Disease Models, Animal; Epilepsy; Esophagus; Female; Gastroesophageal Reflux; Hydrogen-Ion Concentration; Kainic Acid; Laryngismus; Rats, Long-Evans; Respiration; Seizures | 2018 |
Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis.
Topics: Animals; Astrocytes; Connexin 30; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Female; Kainic Acid; Luminescent Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Receptors, Purinergic P2Y1; Signal Transduction; Sodium Channel Blockers; Synapses; Tetrodotoxin; Tumor Necrosis Factor-alpha | 2018 |
A predictive epilepsy index based on probabilistic classification of interictal spike waveforms.
Topics: Action Potentials; Animals; Automation; Diagnosis, Computer-Assisted; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Models, Statistical; Neurophysiological Monitoring; Normal Distribution; Principal Component Analysis; Wavelet Analysis | 2018 |
[Induction of Epileptic Seizures in Mouse Models of Chronic Restraint Stress].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Random Allocation; Restraint, Physical; Seizures; Stress, Psychological | 2018 |
A cynomolgus monkey model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Macaca fascicularis; Male; Seizures; Temporal Lobe | 2019 |
GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Child; Child, Preschool; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Glycogen Synthase Kinase 3 beta; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Kainic Acid; Male; Mice; Mice, Transgenic; Middle Aged; Muscle Proteins; Phosphorylation; Potassium Channels; Receptors, AMPA; Signal Transduction; Synaptic Transmission; Video Recording | 2019 |
Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Convulsants; Disease Models, Animal; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Neuroprotective Agents; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Vitamin D | 2019 |
Lidocaine protects neurons of the spinal cord in an excitotoxicity model.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Lidocaine; Male; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2019 |
Differences in Neurodegeneration Between Kainic Acid-Injected GAERS and Wistar Rats.
Topics: Amygdala; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agonists; Kainic Acid; Male; Neurodegenerative Diseases; Rats; Rats, Wistar; Species Specificity | 2019 |
Protective effects of lycopene on kainic acid-induced seizures.
Topics: Animals; Antioxidants; Blinking; Disease Models, Animal; Drug Administration Schedule; Excitatory Amino Acid Agonists; Gene Expression; Glutathione; Hippocampus; Kainic Acid; Lycopene; Malondialdehyde; Mice; Receptors, GABA; RNA, Messenger; Seizures; Stereotyped Behavior; Superoxide Dismutase; Time Factors | 2019 |
Insulin-like growth factor 1 promotes cochlear synapse regeneration after excitotoxic trauma in vitro.
Topics: Animals; Cochlea; Disease Models, Animal; Hair Cells, Auditory, Inner; Hearing Loss, Sensorineural; Humans; In Vitro Techniques; Insulin-Like Growth Factor I; Kainic Acid; Mice; Mice, Inbred ICR; N-Methylaspartate; Nerve Regeneration; Ototoxicity; Receptor, IGF Type 1; Spiral Ganglion; Synapses | 2019 |
Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar.
Topics: Acoustic Stimulation; Animals; Audiometry, Pure-Tone; Auditory Perception; Auditory Threshold; Behavior, Animal; Cochlear Nerve; Conditioning, Operant; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Female; Humans; Kainic Acid; Male; Melopsittacus; Otoacoustic Emissions, Spontaneous; Ototoxicity; Psychoacoustics | 2019 |
Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.
Topics: Acetamides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lacosamide; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Signal Transduction; Status Epilepticus | 2019 |
Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cytokines; Dinoprostone; Disease Models, Animal; Gliosis; Hippocampus; Indoles; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Receptors, Prostaglandin E, EP2 Subtype; Seizures; Signal Transduction; Status Epilepticus | 2019 |
Histoarchitecture restoration of cerebellar sub-layers as a response to estradiol treatment following Kainic acid-induced spinal cord injury.
Topics: Animals; Astrocytes; Disease Models, Animal; Estradiol; Kainic Acid; Male; Microglia; Purkinje Cells; Rats; Rats, Wistar; Recovery of Function; Spinal Cord Injuries | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Mice; Nerve Net; Pilocarpine; Seizures; Status Epilepticus | 2019 |
Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Recurrence; Seizures | 2019 |
Network pharmacology for antiepileptogenesis: Tolerability and neuroprotective effects of novel multitargeted combination treatments in nonepileptic vs. post-status epilepticus mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Neuroprotective Agents; Psychomotor Disorders; Status Epilepticus | 2019 |
ALG13 Deficiency Associated with Increased Seizure Susceptibility and Severity.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mice; Mice, Knockout; N-Acetylglucosaminyltransferases; Neurons; Seizures; Severity of Illness Index; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Gyrus Cinguli; Hippocampus; Kainic Acid; Macaca mulatta; Magnetic Resonance Imaging; Male; Neurons; Neurosurgical Procedures; Robotic Surgical Procedures; Robotics; Seizures; Temporal Lobe | 2019 |
Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Female; Hippocampus; Kainic Acid; Magnolia; Male; Neurons; Neuroprotective Agents; Plant Extracts; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2019 |
[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures | 2019 |
Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Hippocampus; Kainic Acid; Mice; Seizures; Synaptosomes | 2019 |
Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus.
Topics: Animals; Calcium-Binding Proteins; Cell Death; Cell Proliferation; CX3C Chemokine Receptor 1; Disease Models, Animal; Gliosis; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Monocytes; Neurons; Receptor, Macrophage Colony-Stimulating Factor; Receptors, CCR2; Status Epilepticus; Tissue Culture Techniques | 2019 |
2-Deoxyglucose protects hippocampal neurons against kainate-induced temporal lobe epilepsy by modulating monocyte-derived macrophages (mo-MΦ) and progranulin production in the hippocampus.
Topics: Animals; Deoxyglucose; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Macrophages; Male; Neurons; Neuroprotective Agents; Progranulins; Rats, Wistar | 2019 |
Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Female; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Microglia; Neurons; Seizures; Sex Factors | 2019 |
Altered serotonin innervation in the rat epileptic brain.
Topics: Animals; Brain Stem; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Prosencephalon; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2019 |
Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools.
Topics: Animals; Cognitive Dysfunction; Discrimination Learning; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Maze Learning; Rats; Rats, Wistar; Recognition, Psychology; Reversal Learning; Spatial Memory | 2019 |
MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model of temporal lobe epilepsy.
Topics: Animals; Antagomirs; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Memory Disorders; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Spatial Memory; Status Epilepticus; Temporal Lobe | 2019 |
The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pentylenetetrazole; Seizures | 2019 |
Chronic subconvulsive activity during early postnatal life produces autistic behavior in the absence of neurotoxicity in the juvenile weanling period.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Glutamic Acid; Interpersonal Relations; Kainic Acid; Male; Phenotype; Rats; Sex Factors; Social Behavior; Social Environment | 2019 |
Subventricular zone-derived neural stem cell grafts protect against hippocampal degeneration and restore cognitive function in the mouse following intrahippocampal kainic acid administration.
Topics: Animals; Astrocytes; Behavior, Animal; Cell Movement; Cell Proliferation; Cell Survival; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Insulin-Like Growth Factor I; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Neural Stem Cells; Neurogenesis; Neurons; Spheroids, Cellular; Time Factors; Transduction, Genetic | 2013 |
Increased excitability in tat-transgenic mice: role of tat in HIV-related neurological disorders.
Topics: Analysis of Variance; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Products, tat; Kainic Acid; Male; Mice; Mice, Transgenic; Nervous System Diseases; Neurotransmitter Agents; Seizures; Statistics, Nonparametric; tat Gene Products, Human Immunodeficiency Virus; Vesicular Glutamate Transport Proteins | 2013 |
Persistent neurological damage associated with spontaneous recurrent seizures and atypical aggressive behavior of domoic acid epileptic disease.
Topics: Aggression; Animals; Brain; Cell Count; Disease Models, Animal; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 2013 |
Epilepsy-induced motility of differentiated neurons.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Cell Body; Cell Movement; Dendrites; Disease Models, Animal; Epilepsy; Extracellular Matrix Proteins; Green Fluorescent Proteins; Immunohistochemistry; In Situ Hybridization; Interneurons; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Neurogenesis; Neurons; Patch-Clamp Techniques; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Tissue Culture Techniques | 2014 |
Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures.
Topics: Animals; Cell Death; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; HMGB1 Protein; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neuropeptides; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Seizures; Toll-Like Receptor 4; Up-Regulation | 2013 |
The effect of kainic acid on hippocampal dendritic spine motility at the early and late stages of brain development.
Topics: Animals; Brain; CA1 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Epilepsy; Kainic Acid; Locomotion; Mice; Mice, Transgenic; Time-Lapse Imaging | 2013 |
Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Epilepsy; Excitatory Amino Acid Agonists; GABAergic Neurons; Gene Expression Regulation; Glutamate Decarboxylase; Kainic Acid; Nerve Tissue Proteins; Neurogenesis; Parvalbumins; Rats; Receptors, GABA-A | 2013 |
Possible protecting role of TNF-α in kainic acid-induced neurotoxicity via down-regulation of NFκB signaling pathway.
Topics: Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Knockout; Neurodegenerative Diseases; NF-kappa B; Seizures; Signal Transduction; Tumor Necrosis Factor-alpha | 2013 |
Glucocorticoid signaling in myeloid cells worsens acute CNS injury and inflammation.
Topics: Analysis of Variance; Animals; Brain Infarction; Brain Injuries; Brain-Derived Neurotrophic Factor; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corticosterone; Cytokines; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Green Fluorescent Proteins; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Myeloid Cells; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Receptors, Glucocorticoid; Signal Transduction | 2013 |
EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability.
Topics: Animals; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Glutamic Acid; Guanine Nucleotide Exchange Factors; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kainic Acid; KATP Channels; Male; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Probability; Protein Binding; Quinoxalines; Synaptosomes; Transduction, Genetic | 2013 |
Kainate-induced calcium overload of cortical neurons in vitro: Dependence on expression of AMPAR GluA2-subunit and down-regulation by subnanomolar ouabain.
Topics: Adamantane; Animals; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Female; In Vitro Techniques; Kainic Acid; Nerve Degeneration; Neurons; Ouabain; Patch-Clamp Techniques; Piperidines; Pregnancy; Rats; Rats, Wistar; Receptors, AMPA | 2013 |
Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in an animal seizure model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Neuronal Plasticity; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Synapses; Systemic Inflammatory Response Syndrome | 2013 |
Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Motor Activity; Neurons; Receptor, trkB; Signal Transduction; Status Epilepticus | 2013 |
Bradykinin B₂ receptors increase hippocampal excitability and susceptibility to seizures in mice.
Topics: Animals; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Disease Susceptibility; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Piriform Cortex; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Seizures | 2013 |
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fragile X Mental Retardation Protein; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Synaptic Depression; Phosphorylation; Pregnancy; Protein Phosphatase 2; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ribosomal Protein S6 Kinases, 70-kDa; Seizures; Signal Transduction; Subcellular Fractions; Thiazoles | 2013 |
Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus.
Topics: Aging; Animals; Antibodies; Cytokines; Disease Models, Animal; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2013 |
Prenatal transport stress, postnatal maternal behavior, and offspring sex differentially affect seizure susceptibility in young rats.
Topics: Animals; Animals, Newborn; Brain; Corticosterone; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Female; Kainic Acid; Lipopolysaccharides; Male; Maternal Behavior; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stress, Psychological; Time Factors | 2013 |
Effect of intra-cisternal application of kainic acid on the spinal cord and locomotor activity in rats.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Motor Activity; Neurons; Rats; Rats, Wistar; Spinal Cord | 2013 |
Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Carrier Proteins; Cells, Cultured; Disease Models, Animal; Epilepsy; Fluorine Radioisotopes; Immunoenzyme Techniques; Inflammation; Kainic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Stroke | 2013 |
Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Brain; Disease Models, Animal; DNA Fragmentation; Exploratory Behavior; Kainic Acid; Male; Maze Learning; Mental Disorders; Motor Activity; Rats; Rats, Long-Evans; Rotarod Performance Test; Seizures | 2013 |
GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice.
Topics: Animals; Autoreceptors; Baclofen; CA3 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA-B Receptor Agonists; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Models, Neurological; Nerve Net; Receptors, GABA-B | 2013 |
A macaque model of mesial temporal lobe epilepsy induced by unilateral intrahippocampal injection of kainic Acid.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Macaca; Magnetic Resonance Imaging; Male; Microscopy, Electron | 2013 |
Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Curcumin; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Nitrites; Oxidative Stress; Rats; Rats, Wistar | 2013 |
Effects of brain IKKβ gene silencing by small interfering RNA on P-glycoprotein expression and brain damage in the rat kainic acid-induced seizure model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Gene Expression; I-kappa B Kinase; Kainic Acid; Male; Neurons; NF-kappa B; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Seizures; Transcription, Genetic | 2014 |
Certain secondary antiepileptic drugs can rescue hippocampal injury following a critical growth period despite poor anticonvulsant activity and cognitive deficits.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Body Weight; Brain Injuries; Cell Count; Cognition Disorders; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Kainic Acid; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome | 2013 |
Specific impairment of "what-where-when" episodic-like memory in experimental models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Memory; Memory Disorders; Memory, Episodic; Rats; Rats, Wistar | 2013 |
High-frequency stimulation of the hippocampus protects against seizure activity and hippocampal neuronal apoptosis induced by kainic acid administration in macaques.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Biophysics; Caspase 3; Disease Models, Animal; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Macaca; Magnetic Resonance Imaging; Male; Neurons; Seizures | 2014 |
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
Topics: Adenosine Triphosphate; alpha-Tocopherol; Animals; Ascorbic Acid; Disease Models, Animal; Electric Stimulation; Electroencephalography; Electron Transport Complex I; Epilepsy, Temporal Lobe; Hippocampus; Hydrogen Peroxide; In Vitro Techniques; Kainic Acid; Kv1.1 Potassium Channel; Mice; Mice, Knockout; Mitochondria; Pyruvic Acid; Reactive Oxygen Species; Respiration; Seizures | 2014 |
Systemic administration of fluoro-gold for the histological assessment of vascular structure, integrity and damage.
Topics: Animals; Blood Vessels; Brain; Calcium-Binding Proteins; Cell Adhesion Molecules; Choroid Plexus; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microfilament Proteins; Propidium; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stilbamidines; Time Factors; Wounds, Penetrating | 2014 |
[Expression of growth-associated protein 43 in the hippocampus of mesial temporal lobe epilepsy mouse model].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Mice; Seizures | 2013 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Pilocarpine | 2013 |
Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epile
Topics: Animals; Antioxidants; Behavior, Animal; Blood Pressure; Body Weight; Brain; Circadian Rhythm; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Food Preferences; Kainic Acid; Male; Maze Learning; Melatonin; Rats; Rats, Inbred SHR; Serotonin; Swimming; Time Factors | 2014 |
Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease.
Topics: Animals; Autophagy; Biomarkers; Disease Models, Animal; Dual-Specificity Phosphatases; Electrical Synapses; Epilepsy; Glycogen; Glycogen Synthase; Hippocampus; Humans; Inclusion Bodies; Kainic Acid; Lafora Disease; Mice; Mice, Knockout; Mutation; Protein Tyrosine Phosphatases, Non-Receptor; Ubiquitin-Protein Ligases | 2014 |
Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.
Topics: Action Potentials; Aminopyridines; Analysis of Variance; Animals; Bacterial Proteins; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; GABA Agents; GABA Antagonists; Halorhodopsins; In Vitro Techniques; Kainic Acid; Luminescent Proteins; Membrane Potentials; Mice; Neurons; Optogenetics; Patch-Clamp Techniques; Picrotoxin; Status Epilepticus; Transduction, Genetic | 2014 |
Decreased interaction between FoxO3a and Akt correlates with seizure-induced neuronal death.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 3; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-gamma; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Neurons; Oncogene Protein v-akt; Phosphopyruvate Hydratase; Phosphorylation; Proto-Oncogene Proteins; Seizures; Subcellular Fractions; Time Factors | 2014 |
Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; CD11b Antigen; Cell Death; Disease Models, Animal; Epilepsy; Ganglia, Spinal; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Ligation; Male; Microtubule-Associated Proteins; Neuralgia; Neurotoxins; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tetanus Toxin | 2014 |
Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage.
Topics: Animals; Brain Ischemia; Cell Death; Cell Nucleus; Cytoprotection; Disease Models, Animal; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; HEK293 Cells; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Neurons; Neuroprotective Agents; Nuclear Proteins; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Fusion Proteins; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2014 |
Involvement of autophagy in hypoxic-excitotoxic neuronal death.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Autophagy; Cell Death; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Hypoxia; Hypoxia-Ischemia, Brain; Kainic Acid; Male; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley | 2014 |
Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Calcium-Binding Proteins; Cell Death; Corpus Striatum; CX3C Chemokine Receptor 1; Disease Models, Animal; Kainic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; Microinjections; Monocytes; Neurons; Neuroprotection; Nuclear Receptor Subfamily 4, Group A, Member 1; Receptors, Chemokine | 2015 |
Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures.
Topics: Action Potentials; Animals; Arginine; Brain; Cell Line; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Kidney; Male; Mass Spectrometry; Methylation; NAV1.2 Voltage-Gated Sodium Channel; Phosphorylation; Proteomics; Rats | 2014 |
Increased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injury.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cyclohexylamines; Disease Models, Animal; Ganglia, Spinal; Glutamic Acid; Kainic Acid; Male; Neurons; Peripheral Nerve Injuries; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Sciatic Nerve | 2014 |
P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage.
Topics: Amygdala; Animals; Animals, Newborn; Bumetanide; Cell Death; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Male; Purinergic P2X Receptor Antagonists; Pyridines; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Potassium Chloride Symporter Inhibitors; Status Epilepticus; Tetrazoles | 2014 |
Unexpected epilepsy model found in sea lions.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Sea Lions; Temporal Lobe; Water Pollutants, Chemical | 2014 |
Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures.
Topics: Animals; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Kainic Acid; Long-Term Synaptic Depression; MAP Kinase Signaling System; Membrane Potentials; Proteasome Endopeptidase Complex; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ribosomal Protein S6 Kinases; Seizures; Signal Transduction; Synapses; Tissue Culture Techniques; TOR Serine-Threonine Kinases | 2014 |
Advantages of repeated low dose against single high dose of kainate in C57BL/6J mouse model of status epilepticus: behavioral and electroencephalographic studies.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Status Epilepticus | 2014 |
A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo.
Topics: Animals; Astrocytes; Brain; Citric Acid Cycle; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Glutamine; Kainic Acid; Lactates; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL | 2014 |
Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Exploratory Behavior; Kainic Acid; Male; Maze Learning; Memory, Short-Term; Motor Activity; Neuropsychological Tests; Pilocarpine; Random Allocation; Rats, Sprague-Dawley; Recognition, Psychology; Spatial Memory; Status Epilepticus | 2014 |
Long-term modifications of epileptogenesis and hippocampal rhythms after prolonged hyperthermic seizures in the mouse.
Topics: Animals; Delta Rhythm; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electroencephalography; Epilepsy, Temporal Lobe; Female; Gamma Rhythm; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neuropeptides; Seizures, Febrile; Theta Rhythm | 2014 |
The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions.
Topics: Animals; Astrocytes; Cell Proliferation; Central Nervous System Agents; Disease Models, Animal; Hedgehog Proteins; Hippocampus; Kainic Acid; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Neurogenesis; Neurons; Seizures; Severity of Illness Index; Signal Transduction; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2014 |
Glycyrrhizin suppresses HMGB1 inductions in the hippocampus and subsequent accumulation in serum of a kainic acid-induced seizure mouse model.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Models, Animal; Endothelial Cells; Glycyrrhizic Acid; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Mice, Inbred BALB C; Neuroglia; Neurons; Protein Transport; Seizures | 2014 |
Neonatal domoic acid abolishes latent inhibition in male but not female rats and has differential interactions with social isolation.
Topics: Age Factors; Animals; Animals, Newborn; Attention; Conditioning, Psychological; Disease Models, Animal; Female; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Schizophrenia; Social Isolation | 2014 |
Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice.
Topics: Animals; Autoradiography; Disease Models, Animal; Epilepsy, Temporal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kainic Acid; Male; Mice; Neocortex; Neuropeptide Y; Peptide YY; Receptors, Neuropeptide Y; RNA, Messenger; Seizures; Time Factors | 2014 |
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Biophysics; Carbamazepine; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Membrane Potentials; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Sodium Channels | 2014 |
[The impact and mechanism of glutamate transporter 1-mediated visceral nociception and hyperalgesia following exposure to post-traumatic stress disorder-like stress in spinal cord of rats].
Topics: Amino Acid Transport System X-AG; Animals; Ceftriaxone; Disease Models, Animal; Glutamates; Hyperalgesia; Kainic Acid; Nociception; Rats; Spinal Cord; Stress Disorders, Post-Traumatic; Up-Regulation | 2014 |
Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
Topics: Animals; Biological Transport; Dark Adaptation; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 5; Glutamates; Immunohistochemistry; Intravitreal Injections; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Photoreceptor Cells; Retina; Retinal Bipolar Cells; Synaptic Transmission | 2014 |
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.
Topics: Age Factors; Amines; Animals; Animals, Newborn; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Freezing; Gabapentin; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamic Acid; In Vitro Techniques; Kainic Acid; Malformations of Cortical Development; Mice; Mice, Inbred C57BL; Neuroimaging; Patch-Clamp Techniques; Somatosensory Cortex; Thrombospondins | 2014 |
Neuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Apolipoproteins E; Cell Death; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Ocular Hypertension; Optic Nerve Injuries; Receptors, Kainic Acid; Retinal Degeneration; Retinal Ganglion Cells; Signal Transduction; Stilbamidines | 2014 |
Protein kinase C is essential for kainate-induced anxiety-related behavior and glutamatergic synapse upregulation in prelimbic cortex.
Topics: Animals; Anxiety; Bacterial Proteins; Benzophenanthridines; Dendritic Spines; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; Luminescent Proteins; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prefrontal Cortex; Protein Kinase C; Synapses; Up-Regulation | 2014 |
Loss of SIRT4 decreases GLT-1-dependent glutamate uptake and increases sensitivity to kainic acid.
Topics: Animals; Biotinylation; Brain; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Female; Gene Expression Regulation; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Knockout; Mitochondrial Proteins; Neurons; Seizures; Sirtuins; Synaptosomes | 2014 |
Synthesis, anticonvulsant properties, and SAR analysis of differently substituted pyrrolidine-2,5-diones and piperidine-2,6-diones.
Topics: Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Drug Design; Electric Stimulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Molecular Structure; Neuroprotective Agents; Pentylenetetrazole; Piperidones; Seizures; Structure-Activity Relationship; Succinimides; Time Factors | 2014 |
Raloxifene protects against seizures and neurodegeneration in a mouse model mimicking epilepsy in postmenopausal woman.
Topics: Animals; Bone Density; Cyclohexenes; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Neurodegenerative Diseases; Neurons; Postmenopause; Raloxifene Hydrochloride; Seizures; Transforming Growth Factor beta3; Vinyl Compounds | 2014 |
BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain-Derived Neurotrophic Factor; Calpain; Chlorides; Disease Models, Animal; Hippocampus; K Cl- Cotransporters; Kainic Acid; Mice, Knockout; Neurons; Seizures; Status Epilepticus; Symporters; Tissue Culture Techniques; Up-Regulation | 2015 |
Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis.
Topics: Action Potentials; Animals; Disease Models, Animal; ELAV Proteins; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Kainic Acid; Kv1.1 Potassium Channel; Male; MicroRNAs; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sirolimus; Status Epilepticus; Synaptic Transmission; Time Factors; TOR Serine-Threonine Kinases | 2015 |
Nanoencapsulation of the sasanquasaponin from Camellia oleifera, its photo responsiveness and neuroprotective effects.
Topics: Animals; Behavior, Animal; Brain; Camellia; Chlorophyll; Cytokines; Disease Models, Animal; Kainic Acid; Light; Male; Mice; Mice, Inbred C57BL; Nanocapsules; Neurodegenerative Diseases; Neuroprotective Agents; Particle Size; Photosensitizing Agents; Saponins; Tyrosine 3-Monooxygenase | 2014 |
p75NTR, but not proNGF, is upregulated following status epilepticus in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Fluoresceins; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; Muscarinic Agonists; Nerve Growth Factor; Nerve Tissue Proteins; Pilocarpine; Protein Precursors; Receptor, Nerve Growth Factor; Status Epilepticus; Time Factors; Up-Regulation | 2014 |
Susceptibility to seizure-induced excitotoxic cell death is regulated by an epistatic interaction between Chr 18 (Sicd1) and Chr 15 (Sicd2) loci in mice.
Topics: Animals; Behavior, Animal; Cell Death; Chromosomes, Mammalian; Disease Models, Animal; Epistasis, Genetic; Genetic Loci; Genotype; Hippocampus; Kainic Acid; Mice; Microsatellite Repeats; Neurons; Phenotype; Physical Chromosome Mapping; Quantitative Trait Loci; Seizures | 2014 |
Variable electrobehavioral patterns during focal nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid.
Topics: Animals; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Functional Laterality; Guinea Pigs; Hippocampus; Kainic Acid; Male; Status Epilepticus; Time Factors; Video Recording | 2014 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Synergism; Electric Stimulation; Kainic Acid; Lithium; Male; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2015 |
Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death.
Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Death; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Hippocampus; Kainic Acid; Male; Microglia; Neurons; Nootropic Agents; Pilocarpine; Rats; Rats, Sprague-Dawley | 2015 |
Changes and overlapping distribution in the expression of CB1/OX1-GPCRs in rat hippocampus by kainic acid-induced status epilepticus.
Topics: Animals; Antigens, Nuclear; Cell Membrane; Disease Models, Animal; Disease Progression; Fluorescent Antibody Technique; Hippocampus; Immunohistochemistry; Indoles; Kainic Acid; Male; Nerve Tissue Proteins; Orexin Receptors; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Status Epilepticus | 2015 |
Activation of AKT/GSK3β pathway by TDZD-8 attenuates kainic acid induced neurodegeneration but not seizures in mice.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain; Caspase 3; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Kainic Acid; Male; Mice; Neurodegenerative Diseases; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; Seizures; Signal Transduction; Thiadiazoles | 2015 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Ethanol; Female; Kainic Acid; Mice; Nordazepam; Oxazepam; Seizures; Solvents; Temazepam; Water | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Levetiracetam; Mice; Phenobarbital; Phenytoin; Piracetam; Seizures; Valproic Acid | 2015 |
Suppression of adult neurogenesis increases the acute effects of kainic acid.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Electroencephalography; Ethosuximide; Excitatory Amino Acid Agonists; Ganciclovir; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuropeptides; Seizures; Thymidine Kinase; Valganciclovir; X-Rays | 2015 |
Neuroprotective and anti-inflammatory roles of the phosphatase and tensin homolog deleted on chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; Anti-Inflammatory Agents; CA3 Region, Hippocampal; Cell Death; Disease Models, Animal; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Phosphoproteins; Protein Transport; PTEN Phosphohydrolase; Signal Transduction | 2014 |
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.
Topics: Acute Disease; Animals; Bumetanide; Chronic Disease; Corticosterone; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; K Cl- Cotransporters; Kainic Acid; Male; Membrane Potentials; Mice, Inbred C57BL; Phosphorylation; Pyramidal Cells; Restraint, Physical; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2; Stress, Psychological; Symporters | 2015 |
The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Kainic Acid; Male; Rabbits; Retinal Diseases; Retinal Photoreceptor Cell Outer Segment; Retinal Pigment Epithelium; Time Factors; Tomography, Optical Coherence | 2014 |
Age-dependent long-term structural and functional effects of early-life seizures: evidence for a hippocampal critical period influencing plasticity in adulthood.
Topics: Animals; Animals, Newborn; Atrophy; Corpus Callosum; Diffusion Tensor Imaging; Disease Models, Animal; Female; Hippocampus; Hyperthermia, Induced; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Neural Pathways; Pentylenetetrazole; Rats, Sprague-Dawley; Seizures | 2015 |
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.
Topics: Action Potentials; Animals; Animals, Newborn; Disease Models, Animal; Edetic Acid; Excitatory Amino Acid Agonists; Fluoresceins; Gamma Rhythm; Gene Expression Regulation; Hippocampus; Homeostasis; In Vitro Techniques; K Cl- Cotransporters; Kainic Acid; Mice; Mice, Transgenic; Protein Transport; Receptors, G-Protein-Coupled; Seizures; Statistics, Nonparametric; Symporters; Zinc | 2015 |
Cholesterol metabolite cholestane-3β,5α,6β-triol suppresses epileptic seizures by negative modulation of voltage-gated sodium channels.
Topics: Animals; Anticonvulsants; Cholestanols; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2015 |
Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms.
Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Conditioning, Psychological; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Transporter 2; Fear; Kainic Acid; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Self Administration | 2015 |
Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy.
Topics: Acute Disease; Animals; Antioxidants; Cell Respiration; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Glycolysis; Hippocampus; Kainic Acid; Male; Mice, Knockout; Mitochondria; Oxygen; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2015 |
Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Midazolam; Neural Inhibition; Neurons; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Brain; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Humans; Kainic Acid; Male; Malondialdehyde; Mice, Knockout; Mice, Transgenic; Oxidative Stress; Pentylenetetrazole; Presenilin-1; Seizures; Sodium-Coupled Vitamin C Transporters | 2015 |
Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype.
Topics: Age Factors; Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures; Social Behavior | 2015 |
Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats.
Topics: Animals; Disease Models, Animal; Electroencephalography; Glutamic Acid; Hippocampus; Housing, Animal; Kainic Acid; Male; Random Allocation; Rats, Sprague-Dawley; Running; Seizures; Telemetry | 2015 |
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Knockout; Microglia; Neurons; Peptides, Cyclic; Pilocarpine; Receptor, Anaphylatoxin C5a; Seizures; Tumor Necrosis Factor-alpha | 2015 |
Age-dependent changes in intrinsic neuronal excitability in subiculum after status epilepticus.
Topics: Age Factors; Animals; Disease Models, Animal; Hippocampus; Kainic Acid; Neurons; Rats; Status Epilepticus | 2015 |
Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus.
Topics: Amygdala; Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Rats; Rats, Wistar; Spectrin | 2015 |
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Mice; Nitriles; Phenytoin; Pyridones; Quinoxalines; Receptors, AMPA; Seizures; Status Epilepticus | 2015 |
Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.
Topics: Analysis of Variance; Animals; Arginase; beta-N-Acetylhexosaminidases; Convulsants; Cytokines; Disease Models, Animal; Epilepsy; Flow Cytometry; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Lectins; Male; Mice; Microglia; Pilocarpine; Time Factors | 2015 |
[Effect of licorice flavonoids on kainic acid-induced seizure in mice].
Topics: Animals; Disease Models, Animal; Flavonoids; Glycyrrhiza; Kainic Acid; Male; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Neurogenesis; Seizures; Status Epilepticus | 2015 |
Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Menstrual Cycle; Pilocarpine; Rats, Sprague-Dawley; Sex Factors; Status Epilepticus | 2015 |
Predicting and treating stress-induced vulnerability to epilepsy and depression.
Topics: Allostasis; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Depression; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flavones; Hypothalamo-Hypophyseal System; Kainic Acid; Male; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Social Environment; Status Epilepticus; Stress, Psychological | 2015 |
Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.
Topics: Animals; Astrocytes; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Homeostasis; Kainic Acid; Locomotion; Mice; Mice, Inbred C57BL; Mice, Transgenic; Psychomotor Disorders; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Time Factors; Triazoles | 2015 |
Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: Underlying mechanisms.
Topics: Animals; Antioxidants; Cinnamates; Depsides; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Rosmarinic Acid | 2015 |
Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Dopamine; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Naphthyridines; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Status Epilepticus | 2015 |
Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Seizures; Social Behavior; Status Epilepticus; Ultrasonography, Interventional | 2015 |
FTY720 attenuates excitotoxicity and neuroinflammation.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Brain Diseases; Cell Death; Cells, Cultured; Cerebellum; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fingolimod Hydrochloride; In Vitro Techniques; Kainic Acid; L-Lactate Dehydrogenase (Cytochrome); Male; N-Methylaspartate; Neurons; Organ Culture Techniques; Phosphorylation; Rats; Rats, Sprague-Dawley; Time Factors | 2015 |
Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.
Topics: Adult; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Psychomotor Agitation | 2015 |
Continuous monitoring of highly reactive oxygen radicals during in vivo microdialysis.
Topics: Analysis of Variance; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescence; Kainic Acid; Male; Microdialysis; Neostriatum; Neurotoxicity Syndromes; Online Systems; Phthalic Acids; Rats; Rats, Wistar; Reactive Oxygen Species; Taurine; Time Factors | 2015 |
Maternal immune activation increases seizure susceptibility in juvenile rat offspring.
Topics: Animals; Animals, Newborn; Anxiety; Brain Injuries; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures | 2015 |
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Apoptosis; CA3 Region, Hippocampal; Child; Child, Preschool; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Kainic Acid; Kindling, Neurologic; Male; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; RNA Interference; Seizures; Young Adult | 2015 |
Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; Ceftriaxone; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Excitatory Amino Acid Transporter 2; Extracellular Space; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Microdialysis; Nucleus Accumbens; Rats | 2015 |
Functional and histopathological changes induced by intraparenchymal injection of kainic acid in the rat cervical spinal cord.
Topics: Analysis of Variance; Animals; Body Weight; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Functional Laterality; Kainic Acid; Male; Motor Activity; Neurotoxicity Syndromes; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reflex; Sensory Thresholds; Spinal Cord; Time Factors | 2015 |
Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1).
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Behavior, Animal; Brain; Brain Waves; Cyclooxygenase 2; Disease Models, Animal; Electroencephalography; Emodin; Epilepsy; Female; Kainic Acid; Microscopy, Confocal; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2015 |
Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.
Topics: Animals; Autistic Disorder; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Hippocampus; Interleukin-1beta; Interleukin-6; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Pregnancy; Seizures; Status Epilepticus | 2015 |
Cav3.1 T-type calcium channel modulates the epileptogenicity of hippocampal seizures in the kainic acid-induced temporal lobe epilepsy model.
Topics: Animals; Calcium Channels, T-Type; Cerebral Cortex; Delta Rhythm; Disease Models, Animal; Electrocorticography; Electrodes, Implanted; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Seizures; Status Epilepticus; Time Factors | 2015 |
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Neurofeedback; Potassium Channel Blockers; Rats; Seizures | 2015 |
Enhanced nonsynaptic epileptiform activity in the dentate gyrus after kainate-induced status epilepticus.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Cell Count; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agonists; K Cl- Cotransporters; Kainic Acid; Male; Microglia; Pyramidal Cells; Rats, Wistar; Solute Carrier Family 12, Member 2; Status Epilepticus; Symporters | 2015 |
Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.
Topics: Animals; Biomarkers; Cell Death; Cell Line; Cytokines; Disease Models, Animal; Gene Expression; Genetic Predisposition to Disease; Gliosis; Hippocampus; Inflammation Mediators; Kainic Acid; Mice; Mice, Knockout; PrPC Proteins; Seizures; Transfection | 2015 |
Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Injections, Intraperitoneal; Kainic Acid; Male; Mice, Inbred C57BL; Monitoring, Physiologic; Severity of Illness Index; Status Epilepticus; Telemetry; Time Factors; Video Recording | 2015 |
GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA Agents; Hippocampus; Humans; Interleukin-1beta; Kainic Acid; Male; Middle Aged; Oocytes; Patch-Clamp Techniques; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Culture Techniques; Transplantation, Heterologous; Xenopus; Young Adult | 2015 |
Activating mitochondrial function and haemoglobin expression with EH-201, an inducer of erythropoietin in neuronal cells, reverses memory impairment.
Topics: Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Erythropoietin; Female; Glucosides; Hemoglobins; Hydrogen Peroxide; Kainic Acid; Male; Memory Disorders; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; PC12 Cells; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Reactive Oxygen Species; Stilbenes; Succinate Dehydrogenase; Transcription Factors | 2015 |
Effect of sparteine on status epilepticus induced in rats by pentylenetetrazole, pilocarpine and kainic acid.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Disease Models, Animal; Electroencephalography; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Wistar; Sparteine; Status Epilepticus | 2015 |
Effects of eugenol on granule cell dispersion in a mouse model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; Eugenol; Hippocampus; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Multiprotein Complexes; Neurons; TOR Serine-Threonine Kinases | 2015 |
Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
Topics: Animals; Carbohydrate Sulfotransferases; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neurons; Parvalbumins; Plant Lectins; Receptors, N-Acetylglucosamine; Semaphorin-3A; Sulfotransferases; Time Factors | 2015 |
Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression Regulation; Histone Deacetylase 1; Histone Deacetylases; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Pilocarpine; Telemetry; Time Factors; Video Recording | 2015 |
Expression level and distribution of HMGB1 in Sombati's cell model and kainic acid-induced epilepsy model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Mice; Neurons; Rats; Rats, Sprague-Dawley | 2015 |
Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral changes.
Topics: Angiotensin II; Animals; Anticonvulsants; Behavior, Animal; CA1 Region, Hippocampal; Circadian Rhythm; Disease Models, Animal; Infusions, Intraventricular; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Spatial Memory; Status Epilepticus | 2015 |
Exposure to prenatal stress has deleterious effects on hippocampal function in a febrile seizure rat model.
Topics: Animals; Anxiety; Apoptosis; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Mitochondria; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Seizures, Febrile; Sex Characteristics; Spatial Navigation; Stress, Psychological | 2015 |
Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Hippocampus; Kainic Acid; Lorazepam; Male; Mice; Mice, Inbred C57BL; Midazolam; Status Epilepticus; Treatment Outcome | 2015 |
Glycine transporter 1 is a target for the treatment of epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Dioxoles; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Glycine Plasma Membrane Transport Proteins; Hippocampus; Humans; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Rats, Sprague-Dawley; Seizures | 2015 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Tyrosine | 2015 |
Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Dark Adaptation; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Agonists; Exercise Test; Exploratory Behavior; Food Preferences; Kainic Acid; Male; Maze Learning; Mood Disorders; Neurons; Physical Endurance; Rats; Rats, Inbred SHR; Recognition, Psychology; Serotonin; Status Epilepticus | 2015 |
Contrasting features of ERK1/2 activity and synapsin I phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo.
Topics: Animals; Brain; Disease Models, Animal; Enzyme Activation; Excitatory Amino Acid Agonists; Kainic Acid; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Phosphorylation; Rats; Rats, Wistar; Status Epilepticus; Synapsins | 2015 |
Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats.
Topics: 4-Aminopyridine; Animals; Calcium; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hesperidin; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neuroprotective Agents; Neurotoxicity Syndromes; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptosomes; Tetrodotoxin | 2015 |
Houttuyniae Herba Attenuates Kainic Acid-Induced Neurotoxicity via Calcium Response Modulation in the Mouse Hippocampus.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Disease Models, Animal; Hippocampus; Houttuynia; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Seizures | 2015 |
The systemic kainic acid rat model of temporal lobe epilepsy: Long-term EEG monitoring.
Topics: Analysis of Variance; Animals; Brain; Brain Waves; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley | 2015 |
Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis.
Topics: Animals; Autoradiography; Brain; Carrier Proteins; Chronic Disease; Disease Models, Animal; Disease Progression; Electrocorticography; Encephalitis; Epilepsy; Follow-Up Studies; Immunohistochemistry; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nerve Degeneration; Neuroglia; Neurons; Positron-Emission Tomography; Rats, Wistar; Receptors, GABA-A | 2015 |
Protection against cognitive impairment and modification of epileptogenesis with curcumin in a post-status epilepticus model of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cognition Disorders; Curcumin; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Rats; Rats, Wistar; Status Epilepticus; Tumor Necrosis Factor-alpha | 2015 |
The anti-inflammatory activity of duloxetine, a serotonin/norepinephrine reuptake inhibitor, prevents kainic acid-induced hippocampal neuronal death in mice.
Topics: Animals; Astrocytes; CA3 Region, Hippocampal; Cell Death; Disease Models, Animal; Duloxetine Hydrochloride; Excitatory Amino Acid Agonists; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred ICR; Microglia; Neuroprotection; Serotonin and Noradrenaline Reuptake Inhibitors; Tumor Necrosis Factor-alpha | 2015 |
Altered taste preference and loss of limbic-projecting serotonergic neurons in the dorsal raphe nucleus of chronically epileptic rats.
Topics: Anhedonia; Animals; Cell Count; Chronic Disease; Depressive Disorder; Disease Models, Animal; Dorsal Raphe Nucleus; Electrocorticography; Epilepsy; Immunohistochemistry; Kainic Acid; Male; Random Allocation; Rats, Wistar; Seizures; Serotonergic Neurons; Status Epilepticus; Taste Perception | 2016 |
Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Functional Laterality; Green Fluorescent Proteins; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Pyramidal Cells; RGS Proteins; Synaptophysin; Time Factors | 2016 |
HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Epilepsy; HMGB1 Protein; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Receptor for Advanced Glycation End Products; Toll-Like Receptor 4 | 2015 |
Role of HSP70 in motoneuron survival after excitotoxic stress in a rat spinal cord injury model in vitro.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Benzoquinones; Cell Death; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Kainic Acid; Lactams, Macrocyclic; Locomotion; Lumbar Vertebrae; Male; Microelectrodes; Motor Neurons; Purine Nucleosides; Rats, Wistar; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae | 2015 |
Evolution of temporal and spectral dynamics of pathologic high-frequency oscillations (pHFOs) during epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Convulsants; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Status Epilepticus | 2015 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Protein Serine-Threonine Kinases; RNA, Messenger; Seizures; Signal Transduction | 2016 |
Forebrain-independent generation of hyperthermic convulsions in infant rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Denervation; Diazepam; Disease Models, Animal; Excitatory Amino Acid Agonists; Hyperthermia, Induced; Kainic Acid; Male; Prosencephalon; Rats; Rats, Wistar; Seizures; Time Factors | 2016 |
Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuropeptides; Nitric Oxide; Nitric Oxide Synthase Type II; Seizures | 2015 |
Alterations to prepulse inhibition magnitude and latency in adult rats following neonatal treatment with domoic acid and social isolation rearing.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Male; Prefrontal Cortex; Prepulse Inhibition; Random Allocation; Rats, Sprague-Dawley; Reflex, Startle; Social Isolation | 2016 |
Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Female; Kainic Acid; Male; Mice; Muscarinic Agonists; Pilocarpine; Sex Factors; Status Epilepticus; Time Factors | 2015 |
A reduced susceptibility to chemoconvulsant stimulation in adenylyl cyclase 8 knockout mice.
Topics: Adenylyl Cyclases; Animals; Cell Death; Convulsants; Disease Models, Animal; Hippocampus; Kainic Acid; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Pilocarpine; Seizures; Status Epilepticus | 2016 |
Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals.
Topics: Animals; Calbindins; Cell Adhesion Molecules, Neuronal; Cholecystokinin; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Extracellular Matrix Proteins; Female; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Male; Miniature Postsynaptic Potentials; Nerve Tissue Proteins; Neural Pathways; Parvalbumins; Presynaptic Terminals; Rats, Wistar; Reelin Protein; Serine Endopeptidases; Tissue Culture Techniques | 2016 |
Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Vessels; Blood-Brain Barrier; Brain; Disease Models, Animal; Electric Impedance; Excitatory Amino Acid Agonists; Gliosis; Immunosuppressive Agents; Kainic Acid; Lectins; Macrophages; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Sirolimus; Status Epilepticus; Tumor Necrosis Factor-alpha | 2016 |
Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Capillary Permeability; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Follow-Up Studies; Kainic Acid; Magnetic Resonance Imaging; Male; Phospholipids; Rats; Rats, Sprague-Dawley; Sirolimus; Status Epilepticus; Sulfur Hexafluoride; Time Factors; Video Recording | 2016 |
The Glt1 glutamate receptor mediates the establishment and perpetuation of chronic visceral pain in an animal model of stress-induced bladder hyperalgesia.
Topics: Animals; Behavior, Animal; Ceftriaxone; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Female; Gastrointestinal Motility; Hyperalgesia; Kainic Acid; Rats; Rats, Inbred WKY; Spinal Cord; Stress, Physiological; Urinary Bladder; Visceral Pain | 2016 |
Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure.
Topics: Acute Disease; Animals; Animals, Newborn; Blotting, Western; CA1 Region, Hippocampal; Disease Models, Animal; Excitatory Postsynaptic Potentials; Kainic Acid; Long-Term Potentiation; Male; Patch-Clamp Techniques; Phosphorylation; Pyramidal Cells; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Time; Tissue Culture Techniques | 2016 |
Inhibiting HIF-1α Decreases Expression of TNF-α and Caspase-3 in Specific Brain Regions Exposed Kainic Acid-Induced Status Epilepticus.
Topics: 2-Methoxyestradiol; Amygdala; Animals; Brain; Caspase 3; Disease Models, Animal; Estradiol; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Kainic Acid; Male; Parietal Lobe; Rats; Rats, Wistar; Status Epilepticus; Tumor Necrosis Factor-alpha; Up-Regulation | 2016 |
Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats.
Topics: Animals; Calcium-Binding Proteins; Cardiovascular Abnormalities; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gamma Rhythm; Kainic Acid; Male; Medulla Oblongata; Microfilament Proteins; Microglia; Minocycline; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures; Splanchnic Nerves; Tyrosine 3-Monooxygenase; Vagotomy | 2016 |
Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects.
Topics: Animals; Asia, Eastern; Caspase 3; Cell Survival; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Memory, Short-Term; Mice; Neuroprotective Agents; Nootropic Agents; Plant Extracts; Plants, Medicinal; Spatial Memory | 2016 |
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Seizures; Time Factors; Urate Oxidase; Uric Acid; Video Recording | 2016 |
Fetal domoic acid exposure affects lateral amygdala neurons, diminishes social investigation and alters sensory-motor gating.
Topics: Acoustic Stimulation; Age Factors; Amygdala; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; Female; Interpersonal Relations; Kainic Acid; Male; Mice; Neurons; Neurotoxins; Parvalbumins; Phosphopyruvate Hydratase; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Psychoacoustics; Sensory Gating; Sex Factors; Vocalization, Animal | 2016 |
A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers.
Topics: Animals; CX3C Chemokine Receptor 1; Disease Models, Animal; Disease Susceptibility; Green Fluorescent Proteins; Hippocampus; Hot Temperature; Interleukin-1beta; Kainic Acid; Lipopolysaccharides; Mice, Transgenic; Microglia; Neuroimmunomodulation; Nitric Oxide Synthase Type II; Receptors, Chemokine; RNA, Messenger; Seizures, Febrile; Status Epilepticus; Tumor Necrosis Factor-alpha | 2015 |
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures.
Topics: Animals; Astrocytes; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Metabotropic Glutamate 5; Seizures; Status Epilepticus | 2016 |
Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fourier Analysis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures; Time Factors; Treatment Outcome | 2016 |
Evidence for Status Epilepticus and Pro-Inflammatory Changes after Intranasal Kainic Acid Administration in Mice.
Topics: Administration, Intranasal; Animals; Astrocytes; Behavior, Animal; Disease Models, Animal; Electroencephalography; Inflammation; Kainic Acid; Mice; Mice, Transgenic; Microglia; Status Epilepticus | 2016 |
The role of the insular cortex in naloxone-induced conditioned place aversion in morphine-dependent mice.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Kainic Acid; Male; Mental Disorders; Mice; Morphine; Naloxone; Narcotics; Proto-Oncogene Proteins c-fos; Random Allocation; Substance Withdrawal Syndrome | 2016 |
Functional characterization of a mouse model for central post-stroke pain.
Topics: Animals; Collagenases; Disease Models, Animal; Hyperalgesia; Kainic Acid; Lidocaine; Mice, Inbred C57BL; Microinjections; Nerve Fibers, Unmyelinated; Pain; Sensation; Spinal Cord; Stroke; Thalamus; TRPV Cation Channels; Ventral Thalamic Nuclei | 2016 |
The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation.
Topics: Animals; Antibodies; Benzoxazines; Chemokine CCL2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Indazoles; Inflammation; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Piperidines; Propionates; Receptors, CCR2; RNA, Messenger; Signal Transduction; Up-Regulation | 2016 |
Leukocyte Infiltration Triggers Seizure Recurrence in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Kainic Acid; Leukocytes; Neurons; Rats; Recurrence; Seizures | 2016 |
Comparative power spectrum analysis of EEG activity in spontaneously hypertensive and Wistar rats in kainate model of temporal model of epilepsy.
Topics: Animals; Blood Pressure; Brain Mapping; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Spectrum Analysis | 2016 |
Naringin attenuates granule cell dispersion in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Carrier Proteins; Cell Cycle Proteins; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Eukaryotic Initiation Factors; Flavanones; Flavonoids; Humans; Injections, Intraperitoneal; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Neurons; Phosphoproteins | 2016 |
High-Throughput LC-MS/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; High-Throughput Screening Assays; Kainic Acid; Mice; Microglia; Neurodegenerative Diseases; Proteome; Proteomics; Synaptic Transmission; Tandem Mass Spectrometry; Time Factors | 2016 |
Synaptic Remodeling of Entorhinal Input Contributes to an Aberrant Hippocampal Network in Temporal Lobe Epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neuronal Plasticity; Synapses; Tissue Culture Techniques | 2017 |
Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model.
Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Hippocampus; Inhibition, Psychological; Kainic Acid; Neurotransmitter Agents; Rats; Status Epilepticus; Treatment Outcome | 2016 |
Immediate epileptogenesis: Impact on brain in C57BL/6J mouse kainate model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Immunohistochemistry; Kainic Acid; Male; Mice, Inbred C57BL; Seizures; Statistics, Nonparametric; Status Epilepticus | 2016 |
Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; CA1 Region, Hippocampal; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy, Post-Traumatic; Kainic Acid; Levetiracetam; Male; Neurons; Neuroprotective Agents; Piracetam; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Time Factors | 2016 |
Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures.
Topics: Analysis of Variance; Animals; Astrocytes; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Interleukins; Kainic Acid; Mice; Mice, Inbred C57BL; Phosphopyruvate Hydratase; RNA, Messenger; Seizures; Time Factors | 2016 |
Post-treatment with prolactin protects hippocampal CA1 neurons of the ovariectomized female rat against kainic acid-induced neurodegeneration.
Topics: Animals; Antigens, Nuclear; Astrocytes; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Female; Gliosis; Kainic Acid; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurogenesis; Neurons; Neuroprotective Agents; Ovariectomy; Prolactin; Random Allocation; Rats; Time Factors | 2016 |
Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Hippocampus; Interleukin-1beta; Kainic Acid; Mice, Inbred C57BL; Mice, Knockout; Random Allocation; Receptors, Interleukin-1 Type I; Recombinant Proteins; Status Epilepticus | 2016 |
Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy.
Topics: Analysis of Variance; Animals; Aquaporin 4; Astrocytes; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; RNA, Messenger; Time Factors | 2016 |
Non-parametric directionality analysis - Extension for removal of a single common predictor and application to time series.
Topics: Action Potentials; Algorithms; Animals; Cerebral Cortex; Computer Simulation; Data Interpretation, Statistical; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Models, Neurological; Multivariate Analysis; Neurons; Rats; Signal Processing, Computer-Assisted; Software; Time Factors | 2016 |
Kainic acid-induced albumin leak across the blood-brain barrier facilitates epileptiform hyperexcitability in limbic regions.
Topics: Albumins; Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Guinea Pigs; Interleukin-1beta; Kainic Acid; Limbic System; Microscopy, Confocal; Phosphopyruvate Hydratase; Seizures; Serum Albumin; Spectrum Analysis; Subcellular Fractions | 2016 |
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Topics: Age Factors; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Mice; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neuroglia; Neurons; Pentylenetetrazole; Seizures | 2016 |
Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats.
Topics: Animals; CD11b Antigen; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Fluoresceins; Glutamic Acid; Hippocampus; Kainic Acid; Luteolin; Male; Maze Learning; Microscopy, Electron, Transmission; Mitochondria; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2016 |
Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation.
Topics: Acetylation; Animals; Anticonvulsants; Apoptosis; CA1 Region, Hippocampal; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kainic Acid; Male; Microglia; Myeloid Differentiation Factor 88; Neurons; Random Allocation; Rats, Sprague-Dawley; Seizures; Signal Transduction; Toll-Like Receptor 4; Vorinostat | 2016 |
Effects of genistein on cognitive dysfunction and hippocampal synaptic plasticity impairment in an ovariectomized rat kainic acid model of seizure.
Topics: Animals; CA1 Region, Hippocampal; Cognitive Dysfunction; Disease Models, Animal; Female; Genistein; Kainic Acid; Long-Term Potentiation; Memory, Short-Term; Neuronal Plasticity; Ovariectomy; Rats; Rats, Wistar; Seizures; Spatial Learning | 2016 |
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Topics: Animals; Anxiety; Benzazepines; Brain; Calcium-Binding Proteins; Constitutive Androstane Receptor; Disease Models, Animal; Exploratory Behavior; Kainic Acid; Locomotion; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microvessels; Neuroglia; Neurons; Receptors, Cytoplasmic and Nuclear; Recognition, Psychology; Tight Junctions; Zonula Occludens Proteins | 2016 |
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Disease Susceptibility; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Kainic Acid; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1 Type I; Receptors, N-Methyl-D-Aspartate; Seizures, Febrile | 2016 |
A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death.
Topics: Animals; Calcium-Binding Proteins; Cell Death; Cyclooxygenase 2; Disease Models, Animal; Dynamins; Hippocampus; HSP72 Heat-Shock Proteins; Kainic Acid; Male; Mice, Inbred ICR; Microfilament Proteins; Mitochondria; Mitochondrial Dynamics; Mitophagy; Neuroglia; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Quinazolinones; Random Allocation; Seizures; Survival Analysis; Ubiquitin-Protein Ligases | 2016 |
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; Selenic Acid; tau Proteins | 2016 |
The effect of early life status epilepticus on ultrasonic vocalizations in mice.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Kainic Acid; Male; Mice; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Sex Characteristics; Signal Transduction; Status Epilepticus; TOR Serine-Threonine Kinases; Vocalization, Animal | 2016 |
A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Endocannabinoids; Glycerides; Kainic Acid; Locomotion; Motor Neurons; Neural Pathways; Neuroprotection; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Spinal Cord; Spinal Cord Injuries; Tissue Culture Techniques | 2016 |
Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Female; Gene Expression; Gene Knockout Techniques; Humans; Kainic Acid; Lithium; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Transgenic; Neurogenesis; Neurons; Phenotype; Phosphorylation; Protein Interaction Domains and Motifs; Receptors, N-Methyl-D-Aspartate; Seizures; tau Proteins | 2016 |
Bursts of high-frequency repetitive transcranial magnetic stimulation (rTMS), together with lorazepam, suppress seizures in a rat kainate status epilepticus model.
Topics: Animals; Anticonvulsants; Combined Modality Therapy; Disease Models, Animal; Kainic Acid; Lorazepam; Rats; Seizures; Status Epilepticus; Transcranial Magnetic Stimulation; Treatment Outcome | 2016 |
Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord in vitro.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Kainic Acid; Locomotion; Motor Neurons; Neuroprotective Agents; Periodicity; Propofol; Rats; Spinal Cord; Spinal Cord Injuries | 2016 |
Expressions of CCAAT/enhancer-binding Protein Homologous Protein and Calnexin in the Hippocampus of a Mouse Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Calnexin; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Seizures; Transcription Factor CHOP | 2016 |
The ability of anterior thalamic signals to predict seizures in temporal lobe epilepsy in kainate-treated rats.
Topics: Algorithms; Animals; Anterior Thalamic Nuclei; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Time Factors | 2016 |
Correlation between afferent rearrangements and behavioral deficits after local excitotoxic insult in the mammalian vestibule: a rat model of vertigo symptoms.
Topics: Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Ear, Middle; Epithelium; Female; Hair Cells, Vestibular; Injections; Kainic Acid; Models, Biological; Neurons, Afferent; Neurotoxins; Rats, Wistar; Synaptic Vesicles; Synaptophysin; Time Factors; Vertigo; Vestibule, Labyrinth | 2016 |
MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures.
Topics: Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cells, Cultured; Disease Models, Animal; Flurothyl; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Microarray Analysis; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Transcriptome | 2016 |
Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis.
Topics: Animals; Biomarkers; Calcifediol; Chromatography, Liquid; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mass Spectrometry; Metabolomics; Pilot Projects; Plasma; Rats | 2016 |
Selective inhibition of metabotropic glutamate type 1 alpha receptor (mGluR1α) reduces cell proliferation and migration following status epilepticus in early development.
Topics: Age Factors; Animals; Animals, Newborn; Benzoates; Brain; Cell Cycle; Cell Movement; Cell Proliferation; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kainic Acid; Lateral Ventricles; Male; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Rhodamines; Status Epilepticus; Time Factors | 2016 |
Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.
Topics: Animals; Calcium; Calcium Channel Agonists; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Male; Mice; Mice, Knockout; Mitochondria; Neurons; Nitric Oxide; Pyramidal Cells; Ryanodine Receptor Calcium Release Channel | 2016 |
Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model.
Topics: Acoustic Stimulation; Action Potentials; Angelman Syndrome; Animals; Conditioning, Psychological; Disease Models, Animal; Esters; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Female; Hippocampus; Kainic Acid; Ketones; Male; Maze Learning; Mice; Mice, Transgenic; Neuronal Plasticity; Psychomotor Performance; Seizures; Ubiquitin-Protein Ligases | 2016 |
Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.
Topics: Acute Disease; Amino Acids; Animals; Autoradiography; Chronic Disease; Cross-Sectional Studies; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Parietal Lobe; Radiopharmaceuticals; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus; Time Factors; Tritium; Xanthenes | 2016 |
Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Dynamins; Excitatory Amino Acid Agonists; Functional Laterality; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mitochondrial Dynamics; NAD; Neurons; Phosphopyruvate Hydratase; Quinazolinones; Rats; Rats, Sprague-Dawley; Serine; Status Epilepticus | 2016 |
Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticonvulsants; Carrier Proteins; Cell Cycle Proteins; Cytokines; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Eukaryotic Initiation Factors; Excitatory Amino Acid Agonists; Flavanones; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Phosphoproteins | 2016 |
Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure-Induced Behavioral Abnormalities.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anxiety; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Gene Expression Regulation; Homeodomain Proteins; Kainic Acid; Maze Learning; Mechanistic Target of Rapamycin Complex 1; Mental Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Nestin; Nuclear Proteins; Regulatory-Associated Protein of mTOR; Repressor Proteins; Seizures; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Distinct behavioral and epileptic phenotype differences in 129/P mice compared to C57BL/6 mice subject to intraamygdala kainic acid-induced status epilepticus.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Status Epilepticus | 2016 |
Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Electrocorticography; Epilepsy, Temporal Lobe; Female; Inflammation; Isoflurane; Kainic Acid; Magnetic Resonance Imaging; Male; Neuroimaging; Neurons; Paraoxon; Positron-Emission Tomography; Rats | 2016 |
MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.
Topics: Animals; Body Temperature; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamate Decarboxylase; Glutamic Acid; Hallucinogens; Hippocampus; Kainic Acid; Male; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Up-Regulation | 2016 |
Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model.
Topics: Animals; Brain; Death, Sudden; Disease Models, Animal; Heart Arrest; Hypoxia; Ischemia; Kainic Acid; Laryngeal Nerves; Laryngismus; Male; Movement; Rats, Sprague-Dawley; Seizures; Sleep Apnea, Central; Sleep Apnea, Obstructive; Vocal Cords | 2016 |
Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Topics: Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Status Epilepticus; Time Factors | 2016 |
Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Topics: Aldehydes; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Ketones; Male; Memory Disorders; Neuroprotective Agents; Pilocarpine; Random Allocation; Rats, Sprague-Dawley; Salicylanilides; Status Epilepticus | 2017 |
Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carbamazepine; Cyanobacteria; Dipeptides; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Mice, Inbred C57BL; MicroRNAs; Oligonucleotides; para-Aminobenzoates; Random Allocation; Receptors, Interleukin-1 Type I; Time Factors; Toll-Like Receptor 4 | 2017 |
Introducing Euro-Glo, a rare earth metal chelate with numerous applications for the fluorescent localization of myelin and amyloid plaques in brain tissue sections.
Topics: Alzheimer Disease; Animals; Brain; Chelating Agents; Coordination Complexes; Disease Models, Animal; Fluoresceins; Fluorescent Dyes; Kainic Acid; Mice, Transgenic; Myelin Sheath; Phenanthrolines; Phosphates; Plaque, Amyloid; Rats, Sprague-Dawley; Staining and Labeling | 2017 |
Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy.
Topics: Animals; Cerebral Cortex; Connectome; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Limbic System; Male; Nerve Net; Rats; Rats, Long-Evans | 2017 |
Metabolic injury in a variable rat model of post-status epilepticus.
Topics: Animals; Aspartic Acid; Cluster Analysis; Creatine; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolic Diseases; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2016 |
ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Animals; Cell Death; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Indoles; Kainic Acid; Mice; Neuroglia; Neurons; Protons; RNA, Messenger; Spinal Cord; Spinal Cord Injuries; Synaptic Transmission; Tissue Culture Techniques | 2017 |
Deep brain stimulation of the anterior nucleus of the thalamus reverses the gene expression of cytokines and their receptors as well as neuronal degeneration in epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cytokines; Deep Brain Stimulation; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression; Kainic Acid; Male; Microscopy, Electron, Transmission; Neurodegenerative Diseases; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytokine | 2017 |
CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Benzylamines; Chemokine CXCL12; Cognition Disorders; Cyclams; Disease Models, Animal; Epilepsy, Temporal Lobe; Heterocyclic Compounds; Hippocampus; Housing, Animal; Kainic Acid; Male; Neurogenesis; Neurons; Random Allocation; Rats, Wistar; Receptors, CXCR4; Seizures | 2017 |
Acute and spontaneous seizure onset zones in the intraperitoneal kainic acid model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2017 |
Seizure-associated central apnea in a rat model: Evidence for resetting the respiratory rhythm and activation of the diving reflex.
Topics: Animals; Brain; Disease Models, Animal; Diving Reflex; Electrocardiography; Electroencephalography; Heart Rate; Kainic Acid; Male; Plethysmography; Rats, Sprague-Dawley; Respiration; Seizures; Sleep Apnea, Central | 2017 |
A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Humans; Kainic Acid; Lorazepam; Male; Mossy Fibers, Hippocampal; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley; Sclerosis; Video Recording | 2017 |
Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Kainic Acid; Resveratrol; Stilbenes; Up-Regulation | 2017 |
Various modifications of the intrahippocampal kainate model of mesial temporal lobe epilepsy in rats fail to resolve the marked rat-to-mouse differences in type and frequency of spontaneous seizures in this model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Rats; Seizures; Species Specificity; Status Epilepticus | 2017 |
Quercetin attenuates domoic acid-induced cognitive deficits in mice.
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Oxidative Stress; Quercetin; Reactive Oxygen Species | 2018 |
Neuronal inhibition and seizure suppression by acetoacetate and its analog, 2-phenylbutyrate.
Topics: Acetoacetates; Animals; Calcium Channels; Diet, Ketogenic; Disease Models, Animal; Electroencephalography; Female; Hippocampus; In Vitro Techniques; Injections; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neural Inhibition; Organ Culture Techniques; Phenylbutyrates; Pyramidal Cells | 2017 |
Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na,K-ATPase in the rat.
Topics: Adenosine Triphosphate; Age Factors; Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Chlorides; Cholinergic Fibers; Disease Models, Animal; Erythrocyte Membrane; Injections, Intraventricular; Kainic Acid; Male; Potassium; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase; Substrate Specificity | 2008 |
Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions.
Topics: Animals; Cell Death; Cell Line, Transformed; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Female; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Inbred C57BL; Movement Disorders; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Severity of Illness Index; Signal Transduction; Spinal Cord Injuries; Tetrazolium Salts; Thiazoles | 2008 |
Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum.
Topics: Animals; Cerebrum; Citrulline; Dendrites; Disease Models, Animal; Drug Interactions; Female; Functional Laterality; Isoprostanes; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase; Oxidative Stress | 2008 |
Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Disease Progression; Embryo, Mammalian; Epilepsy, Temporal Lobe; Fibroblast Growth Factor 2; Hippocampus; Kainic Acid; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Rats; Rats, Inbred F344; Status Epilepticus; Stem Cell Transplantation; Stem Cells; Time Factors | 2008 |
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death.
Topics: Animals; Atorvastatin; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Ectodysplasins; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Inflammation; Interleukin-1beta; Kainic Acid; Male; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Tumor Necrosis Factor-alpha | 2008 |
Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate.
Topics: Animals; Convulsants; Dentate Gyrus; Depressive Disorder; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Learning Disabilities; Maze Learning; Memory Disorders; Mental Disorders; Mice; Mood Disorders; Nerve Degeneration; Neurocognitive Disorders; Neuropsychological Tests; Status Epilepticus | 2008 |
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.
Topics: Adult; Animals; Apoptosis; Convulsants; Cyclin D1; Disease Models, Animal; Epilepsy; Female; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2008 |
Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Cell Death; Ceramides; Diazepam; Disease Models, Animal; Gene Expression Regulation; In Situ Nick-End Labeling; Kainic Acid; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sphingomyelin Phosphodiesterase; Status Epilepticus; Time Factors | 2008 |
The effect of the ketogenic diet on hippocampal GluR5 and Glu(6 mRNA expression and Q/R site editing in the kainate-induced epilepsy model.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Base Sequence; Behavior, Animal; Body Weight; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression; GluK2 Kainate Receptor; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA Editing; RNA, Messenger | 2008 |
Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice.
Topics: Acetylation; Aging; Analysis of Variance; Animals; Association Learning; Blinking; Conditioning, Classical; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kainic Acid; Male; Memory; Mice; Mice, Mutant Strains; Neurodegenerative Diseases; Pattern Recognition, Visual; Time Factors | 2008 |
Experimental petit mal-like seizure induced by microinjection of kainic acid into the unilateral mediodorsal nucleus of the thalamus.
Topics: Amygdala; Animals; Awareness; Blood Glucose; Disease Models, Animal; Dominance, Cerebral; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Frontal Lobe; Hippocampus; Kainic Acid; Male; Mediodorsal Thalamic Nucleus; Motor Activity; Motor Cortex; Motor Skills; Rats; Rats, Wistar; Somatosensory Cortex; Stereotyped Behavior | 2008 |
The basal ganglia and cerebellum interact in the expression of dystonic movement.
Topics: Animals; Basal Ganglia; Caffeine; Cerebellum; Corpus Striatum; Disability Evaluation; Disease Models, Animal; Dopamine; Dystonic Disorders; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Microdialysis; Neural Pathways | 2008 |
Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Malformations of Cortical Development; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2008 |
A single early-life seizure impairs short-term memory but does not alter spatial learning, recognition memory, or anxiety.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Conditioning, Classical; Disease Models, Animal; Exploratory Behavior; Fear; Female; Kainic Acid; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Pregnancy; Rats; Recognition, Psychology; Seizures; Space Perception | 2008 |
Thalamic pathology in sudden cardiac death in epilepsy: a shed light on mysterious event.
Topics: Animals; Brain; Death, Sudden, Cardiac; Disease Models, Animal; Epilepsy, Temporal Lobe; Heart Arrest; Humans; Ibotenic Acid; Kainic Acid; Magnetic Resonance Imaging; Oxygen Consumption; Pilocarpine; Rats; Thalamic Nuclei | 2008 |
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Death; Corticotropin-Releasing Hormone; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Indoles; Intermediate Filament Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurotoxicity Syndromes; Plant Lectins; Proteins; Reaction Time; RNA, Untranslated; Seizures | 2008 |
Long-term functional restoration by neural progenitor cell transplantation in rat model of cognitive dysfunction: co-transplantation with olfactory ensheathing cells for neurotrophic factor support.
Topics: Acetylcholine; Animals; Cells, Cultured; Coculture Techniques; Cognition Disorders; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Male; Nerve Growth Factors; Nerve Regeneration; Neuroglia; Neurotoxins; Olfactory Bulb; Rats; Rats, Wistar; Recovery of Function; Stem Cell Transplantation; Stem Cells; Treatment Outcome | 2009 |
Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Movement; Cell Proliferation; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Electroencephalography; Fluoresceins; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Organic Chemicals; Patch-Clamp Techniques; Purines; Receptors, Chemokine; Receptors, Purinergic; RNA, Messenger; Signal Transduction; Status Epilepticus; Thionucleotides; Time Factors; Up-Regulation | 2008 |
In vivo seizure induction and pharmacological preconditioning by domoic acid and isodomoic acids A, B and C.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Heptanoic Acids; Hippocampus; Isomerism; Kainic Acid; Male; Marine Toxins; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures | 2008 |
NA+, K+-ATPase activity in the brain of the rats with kainic acid-induced seizures: influence of lamotrigine.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Lamotrigine; Rats; Rats, Wistar; Seizures; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Triazines | 2008 |
NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Synaptic Depression; Male; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Wakefulness | 2009 |
Changes in oscillatory activity of neurons in the medial septal area in animals with a model of chronic temporal epilepsy.
Topics: Action Potentials; Animals; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Neurons; Periodicity; Septum of Brain; Time Factors | 2008 |
Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the rat.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Kainic Acid; Male; Rats; Rats, Long-Evans; Seizures; Transcranial Magnetic Stimulation | 2008 |
Chelation of mitochondrial iron prevents seizure-induced mitochondrial dysfunction and neuronal injury.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bleomycin; Chelating Agents; Colorimetry; Disease Models, Animal; DNA, Mitochondrial; Edetic Acid; Fluoresceins; Glutathione; Glutathione Disulfide; Hippocampus; Iron; Kainic Acid; Male; Mitochondrial Diseases; Organic Chemicals; Rats; Rats, Sprague-Dawley; Status Epilepticus; Subcellular Fractions; Time Factors | 2008 |
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cell Line, Transformed; Cell Transplantation; Central Nervous System; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurotoxicity Syndromes; Oxidopamine; Phenyl Ethers; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, GABA-A; tau Proteins | 2008 |
Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Embryo, Mammalian; Gene Expression Regulation; Glucose; Homeodomain Proteins; Hypoglycemic Agents; Immunoprecipitation; Infarction, Middle Cerebral Artery; Kainic Acid; LIM Domain Proteins; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oxygen; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR gamma; Rosiglitazone; Signal Transduction; Superoxide Dismutase; Thiazolidinediones; Trans-Activators; Transcription Factors | 2008 |
Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Ceftriaxone; Colon; Disease Models, Animal; Ethanol; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Humans; Hyperalgesia; Kainic Acid; Mice; Mice, Transgenic; Pain; Pain Measurement; Pain Threshold; Pressure; Up-Regulation | 2009 |
Prevention of epilepsy by taurine treatments in mice experimental model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Calpain; Cell Death; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy; Immunoblotting; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Neuroglia; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Seizures; Taurine | 2009 |
Cardiac sympathetic nerve activity during kainic acid-induced limbic cortical seizures in rats.
Topics: Animals; Blood Pressure; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Heart Rate; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Sympathetic Nervous System | 2009 |
The proapoptotic BCL-2 homology domain 3-only protein Bim is not critical for acute excitotoxic cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 3; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neurotoxicity Syndromes; Phosphopyruvate Hydratase; Proto-Oncogene Proteins; Seizures; Stereotaxic Techniques; Time Factors | 2009 |
The levels of glutathione and nitrite-nitrate and the expression of Bcl-2 mRNA in ovariectomized rats treated by raloxifene against kainic acid.
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Glutathione; Kainic Acid; Nerve Degeneration; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitrites; Ovariectomy; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger; Selective Estrogen Receptor Modulators; Treatment Outcome; Up-Regulation | 2009 |
Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microglia; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Inbred F344; Seizures; Status Epilepticus; Thalamus | 2008 |
Molecular imaging of retinal gliosis in transgenic mice induced by kainic acid neurotoxicity.
Topics: Animals; Brain Diseases; Diagnostic Imaging; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescence; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Mice; Mice, Transgenic; Neurotoxicity Syndromes; Ophthalmoscopes; Optic Nerve; Retinal Diseases | 2009 |
Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Anti-Dyskinesia Agents; Botulinum Toxins; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2009 |
Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Electron Transport Complex III; Enzyme Activation; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mitochondria; NAD; Nitric Oxide; Peroxynitrous Acid; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Ubiquinone | 2009 |
Exogenous reelin prevents granule cell dispersion in experimental epilepsy.
Topics: Adaptor Protein Complex 1; Analysis of Variance; Animals; Cell Adhesion Molecules, Neuronal; Cell Count; Cell Movement; Dentate Gyrus; Disease Models, Animal; Drug Delivery Systems; Epilepsy; Excitatory Amino Acid Agonists; Extracellular Matrix Proteins; Gene Expression Regulation; Kainic Acid; LDL-Receptor Related Proteins; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neural Inhibition; Neurons; Neuroprotective Agents; Receptors, LDL; Receptors, Lipoprotein; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Time Factors | 2009 |
Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis.
Topics: Adenosine; Adenosine Kinase; Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Green Fluorescent Proteins; Hippocampus; Humans; Indoles; Kainic Acid; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; MicroRNAs; Seizures; Tissue Engineering; Transfection | 2009 |
Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Cell Death; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Hypoxia; Kainic Acid; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Time Factors | 2009 |
Development of spontaneous recurrent seizures after kainate-induced status epilepticus.
Topics: Action Potentials; Animals; Brain; Chronic Disease; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Signal Processing, Computer-Assisted; Status Epilepticus; Telemetry; Time Factors | 2009 |
Neuroprotection against excitotoxic brain injury in mice after ovarian steroid depletion.
Topics: Administration, Cutaneous; Animals; Brain; Carcinogens; Cell Death; Cyclohexenes; Disease Models, Animal; Estrogens; Excitatory Amino Acid Agonists; Female; Hippocampus; Histology; Injections, Intraperitoneal; Injections, Subcutaneous; Kainic Acid; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Ovarian Follicle; Ovariectomy; Ovary; Seizures; Vinyl Compounds | 2009 |
The complement factor C5a receptor is upregulated in NFL-/- mouse motor neurons.
Topics: Amyotrophic Lateral Sclerosis; Animals; Complement C5a; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Neuron Disease; Motor Neurons; Nerve Degeneration; Neurofilament Proteins; Neurotoxins; Receptor, Anaphylatoxin C5a; Up-Regulation | 2009 |
Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cell Differentiation; Cell Survival; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Microglia; Neurogenesis; Neurons; Oligodendroglia; Rats; Rats, Inbred F344; Stem Cell Niche; Stem Cells; Time Factors | 2010 |
A role for the parafascicular thalamic nucleus in the development of morphine dependence and withdrawal.
Topics: Animals; Cell Nucleus; Denervation; Disease Models, Animal; Electrophysiology; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Microscopy, Electron, Transmission; Morphine; Morphine Dependence; Narcotics; Nerve Degeneration; Neurons; Neurotoxins; Organelles; Rats; Rats, Wistar; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance Withdrawal Syndrome | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors | 2009 |
Preservation of mitochondrial integrity and energy metabolism during experimental status epilepticus leads to neuronal apoptotic cell death in the hippocampus of the rat.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Apoptosis; Caspase 3; Disease Models, Animal; DNA Fragmentation; Energy Metabolism; Excitatory Amino Acid Agonists; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2009 |
Unconjugated TAT carrier peptide protects against excitotoxicity.
Topics: Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; tat Gene Products, Human Immunodeficiency Virus; Time Factors | 2009 |
Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat.
Topics: Animals; Cerebral Cortex; Circadian Rhythm; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors; Video Recording | 2009 |
Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Hypnotics and Sedatives; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Microdialysis; Midazolam; Mossy Fibers, Hippocampal; Synapsins; Time Factors; Vesicular Glutamate Transport Protein 1; Zinc | 2009 |
Knockdown and overexpression of NR1 modulates NMDA receptor function.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bromodeoxyuridine; Cell Line, Transformed; Disease Models, Animal; Excitatory Amino Acid Agonists; Fear; Flow Cytometry; Gene Expression; Gene Expression Regulation; Gene Knockdown Techniques; Green Fluorescent Proteins; Hippocampus; Humans; Kainic Acid; Luminescent Proteins; Male; Memory; Microdissection; Neurogenesis; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Seizures; Transfection | 2009 |
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation.
Topics: Animals; Animals, Newborn; Arginine; Biophysical Phenomena; Cells, Cultured; Chromosomes, Artificial, Bacterial; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Generalized; Histidine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; RNA, Messenger; Seizures, Febrile; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2009 |
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Fluoresceins; Gene Expression Regulation; Immunosuppressive Agents; In Situ Nick-End Labeling; Kainic Acid; Male; Mossy Fibers, Hippocampal; Organic Chemicals; Protein Kinases; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Video Recording | 2009 |
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Topics: Amygdala; Animals; Anticonvulsants; Binding Sites; Brain; Disease Models, Animal; Electroshock; Epilepsy; Kainic Acid; Kindling, Neurologic; Levetiracetam; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Pentylenetetrazole; Pharmacogenetics; Phenotype; Piracetam | 2009 |
Calcineurin-mediated GABA(A) receptor dephosphorylation in rats after kainic acid-induced status epilepticus.
Topics: Animals; Behavior, Animal; Calcineurin; Disease Models, Animal; Gene Expression Regulation; Immunosuppressive Agents; Kainic Acid; Male; Phosphorylation; Rats; Rats, Wistar; Receptors, GABA-A; Sirolimus; Status Epilepticus; Tacrolimus; Time Factors | 2009 |
Early-life experience alters response of developing brain to seizures.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Brain; Convulsants; Disease Models, Animal; Encephalitis; Environmental Exposure; Epilepsy; Exploratory Behavior; Female; Gliosis; Hippocampus; Kainic Acid; Male; Maternal Deprivation; Microglia; Nerve Degeneration; Physical Stimulation; Rats; Time | 2009 |
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.
Topics: Animals; Blotting, Western; Cell Count; Cell Culture Techniques; Cell Death; Computational Biology; Disease Models, Animal; Drosophila; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Fluorescence; Forkhead Box Protein O3; Forkhead Transcription Factors; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred C57BL; Motor Neuron Disease; Motor Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tyrosine | 2009 |
[An animal model of Huntington's disease: the development of histopathological changes within the neurotoxic lesions of the striatum in long-term surviving rats].
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Ibotenic Acid; Kainic Acid; Neurotoxins; Rats; Rats, Long-Evans | 2002 |
Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: possible involvement of an impaired synaptic transmission to the 5-HT(2A) receptor.
Topics: Animals; Behavior, Animal; Cytoskeletal Proteins; Disease Models, Animal; Epilepsy; Kainic Acid; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Ritanserin; Synaptic Transmission | 2009 |
Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.
Topics: Animals; Calcium Signaling; Chick Embryo; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Malonates; Mitochondria; Motor Neuron Disease; Motor Neurons; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Organ Culture Techniques; Propionates; Riluzole; Spinal Cord | 2009 |
Protective effects of naloxone in two-hit seizure model.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Behavior, Animal; Cytokines; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Hippocampus; In Situ Nick-End Labeling; Interleukin-1beta; Kainic Acid; Maze Learning; Microglia; Naloxone; Neurons; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2010 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin | 2010 |
Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blood Pressure; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Electrodes, Implanted; Electroencephalography; Frontal Lobe; Kainic Acid; Male; Mice; Receptors, AMPA; Status Epilepticus | 2010 |
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
Topics: Animals; Apoptosis; Baclofen; Disease Models, Animal; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Kainate Receptor; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; MAP Kinase Kinase Kinases; Membrane Proteins; Mitogen-Activated Protein Kinase 10; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Receptors, Kainic Acid; Seizures | 2010 |
Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the dentate gyrus and upregulation of neuropeptide Y in seizure model of rats.
Topics: Animals; Apoptosis; Autoantibodies; CA1 Region, Hippocampal; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Erythropoietin; Hematopoiesis; Kainic Acid; Male; Neurons; Neuropeptide Y; Rats; Rats, Inbred F344; Receptors, Neuropeptide Y; Seizures; Severity of Illness Index; Signal Transduction; Up-Regulation | 2009 |
Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways.
Topics: Animals; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Histocytochemistry; Inflammation; Kainic Acid; Male; Nerve Degeneration; Neuronal Plasticity; Rats; Rats, Inbred F344; Reproducibility of Results; Signal Transduction; Toxicogenetics | 2009 |
Spectral analysis of electrocorticographic activity during pharmacological preconditioning and seizure induction by intrahippocampal domoic acid.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electroencephalography; Hippocampus; Kainic Acid; Linear Models; Male; Rats; Rats, Sprague-Dawley; Seizures; Spectrum Analysis; Statistics, Nonparametric | 2010 |
Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat.
Topics: Animals; Biomarkers; Cell Death; Cytoprotection; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluoresceins; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; HSP72 Heat-Shock Proteins; Insulin-Like Growth Factor I; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organic Chemicals; Rats; Rats, Wistar; Staining and Labeling; Stress, Physiological | 2010 |
Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain.
Topics: Animals; bcl-2-Associated X Protein; Behavior, Animal; Brain; Cell Death; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Vitamin B Complex | 2010 |
The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Drug Interactions; Electroencephalography; Epilepsy; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Microtubules; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Oligopeptides; Rats; Rats, Sprague-Dawley | 2009 |
Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Brain; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Glutamic Acid; Isoquinolines; Kainic Acid; Male; Mice; Mice, Transgenic; Models, Genetic; Neural Inhibition; Oncogene Proteins v-fos; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Seizures | 2010 |
EEG spike activity precedes epilepsy after kainate-induced status epilepticus.
Topics: Action Potentials; Animals; Biomarkers; Brain Injuries; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley; Recurrence; Signal Processing, Computer-Assisted; Status Epilepticus; Telemetry; Time Factors; Video Recording | 2010 |
Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.
Topics: Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Kainic Acid; Memory Disorders; Neurotoxicity Syndromes; Phosphodiesterase Inhibitors; Purines; Pyrimidines; Qa-SNARE Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Triazoles; Tritium; Xanthines | 2010 |
Neuroprotection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cell Survival; Disease Models, Animal; Drug Therapy, Combination; Efferent Pathways; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Locomotion; Motor Neurons; Nerve Fibers, Myelinated; Neurons; Neuroprotective Agents; Posterior Horn Cells; Rats; Rats, Wistar; Spinal Cord Injuries; Time Factors | 2010 |
Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Fluorescence; Fundus Oculi; Glaucoma; Green Fluorescent Proteins; Intraocular Pressure; Kainic Acid; Mice; Molecular Imaging; N-Methylaspartate; Neurotoxins; Retinal Ganglion Cells; Thy-1 Antigens; Time Factors | 2010 |
A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Intercellular Signaling Peptides and Proteins; Kainic Acid; Male; Metallothionein; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Peptides; Rats; Rats, Wistar; Seizures | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Diurnal rhythms of spontaneous recurrent seizures and behavioral alterations of Wistar and spontaneously hypertensive rats in the kainate model of epilepsy.
Topics: Adaptation, Ocular; Animals; Behavioral Symptoms; Blood Pressure; Circadian Rhythm; Disease Models, Animal; Exploratory Behavior; Heart Rate; Hippocampus; Kainic Acid; Male; Maze Learning; Pyramidal Cells; Rats; Rats, Inbred SHR; Rats, Wistar; Reaction Time; Recurrence; Statistics, Nonparametric; Status Epilepticus | 2010 |
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.
Topics: Animals; Cerebral Cortex; Convulsants; Crosses, Genetic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Kainic Acid; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pentylenetetrazole; Reaction Time; Seizures; Selection, Genetic | 2010 |
Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus.
Topics: Animals; Cell Movement; Cerebral Arteries; Cytoprotection; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neovascularization, Pathologic; Nerve Degeneration; Neurogenesis; Neuropeptides; Neurotoxins; Pyramidal Cells; Status Epilepticus; Stem Cells; Urokinase-Type Plasminogen Activator | 2010 |
Sanjoinine A isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions.
Topics: Administration, Oral; Alkaloids; Animals; Anticonvulsants; Apoptosis; Calcium; Cells, Cultured; Chlorides; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Seizures; Ziziphus | 2009 |
Timed changes of synaptic zinc, synaptophysin and MAP2 in medial extended amygdala of epileptic animals are suggestive of reactive neuroplasticity.
Topics: Amygdala; Animals; Biomarkers; Convulsants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Growth Cones; Histocytochemistry; Immunohistochemistry; Kainic Acid; Male; Microtubule-Associated Proteins; Neuronal Plasticity; Presynaptic Terminals; Rats; Rats, Wistar; Septal Nuclei; Staining and Labeling; Synaptophysin; Zinc | 2010 |
Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; CA3 Region, Hippocampal; Disease Models, Animal; DNA; Kainic Acid; Male; Neurons; NF-kappa B; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Status Epilepticus; Time Factors; Transcription Factor RelA; Transcription, Genetic; Up-Regulation | 2010 |
Sex-dependent behavioral effects and morphological changes in the hippocampus after prenatal invasive interventions in rats: implications for animal models of schizophrenia.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Maze Learning; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Schizophrenia; Sex Factors; Social Behavior | 2010 |
Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Male; Neuromuscular Depolarizing Agents; Neurons; Rats; Rats, Sprague-Dawley; Sex Characteristics; Somatostatin | 2010 |
c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Cell Count; Cell Death; Disease Models, Animal; Enzyme Inhibitors; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; Microtubule-Associated Proteins; Neurons; Organic Chemicals; Rats; Rats, Sprague-Dawley; Signal Transduction; Status Epilepticus; Time Factors | 2010 |
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Injections, Intraventricular; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Midkine; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Pyramidal Cells | 2010 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; HMGB1 Protein; Humans; Interleukin-1beta; Kainic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Toll-Like Receptor 4 | 2010 |
Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.
Topics: Animals; Apoptosis; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Ghrelin; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Matrix Metalloproteinase 3; Mice; Mice, Inbred C57BL; Microglia; Neurons; Seizures; Tumor Necrosis Factor-alpha | 2010 |
Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice.
Topics: Animals; Animals, Newborn; Brain; Cell Count; Chi-Square Distribution; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Fluoresceins; Histamine H1 Antagonists; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Organic Chemicals; Receptors, Histamine H1; Seizures; Triprolidine | 2010 |
Zebrafish seizure model identifies p,p -DDE as the dominant contaminant of fetal California sea lions that accounts for synergistic activity with domoic acid.
Topics: Animals; Dichlorodiphenyl Dichloroethylene; Disease Models, Animal; Environmental Pollutants; Fetus; Halogenated Diphenyl Ethers; Hexachlorocyclohexane; Kainic Acid; Polychlorinated Biphenyls; Seizures; Zebrafish | 2010 |
In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; GluK2 Kainate Receptor; Hippocampus; Isomerism; Kainic Acid; Male; Models, Molecular; Molecular Conformation; Neuromuscular Depolarizing Agents; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Synaptosomes; Tritium | 2010 |
Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury.
Topics: Animals; Brain; Brain Ischemia; Ceftriaxone; Cerebral Infarction; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Neuroglia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation | 2010 |
The control of kainic acid-induced status epilepticus.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Excitatory Amino Acid Antagonists; Kainic Acid; Ketamine; Male; Rats; Rats, Wistar; Status Epilepticus | 2010 |
Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Escape Reaction; Homocysteine; Kainic Acid; Male; Molsidomine; Panic Disorder; Periaqueductal Gray; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2010 |
Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Anticonvulsants; Antimetabolites; Blood Glucose; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Kainic Acid; Kindling, Neurologic; Male; Mice; Movement Disorders; Pentylenetetrazole; Rats; Seizures; Time Factors | 2010 |
Epileptic focus stimulation and seizure control in the rat model of kainic acid-induced limbic seizures.
Topics: Amygdala; Animals; Deep Brain Stimulation; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Linear Models; Male; Neural Pathways; Rats; Rats, Wistar; Seizures; Status Epilepticus; Stereotaxic Techniques; Thalamus | 2010 |
Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory.
Topics: Animals; Astrocytes; Brain; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Kainic Acid; Male; Maze Learning; Memory Disorders; Mood Disorders; Motor Activity; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Self Administration | 2010 |
In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis.
Topics: Animals; Astrocytes; Autoimmune Diseases of the Nervous System; Brain; Brain Injuries; Disease Models, Animal; Encephalitis; Epilepsy; Female; Globins; Immunohistochemistry; Kainic Acid; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroglobin; Neurons | 2010 |
Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models.
Topics: Acetone; Animals; Anticonvulsants; Butanones; Carbolines; Disease Models, Animal; Electroshock; Kainic Acid; Male; Mice; Motor Activity; Pentanones; Pentylenetetrazole; Seizures | 2010 |
PSA-NCAM-dependent GDNF signaling limits neurodegeneration and epileptogenesis in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Focal Adhesion Protein-Tyrosine Kinases; Glial Cell Line-Derived Neurotrophic Factor; Glycoside Hydrolases; Hippocampus; Kainic Acid; Male; Mice; Nerve Degeneration; Neural Cell Adhesion Molecule L1; Neuroprotective Agents; Sialic Acids; Signal Transduction | 2010 |
Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Homeodomain Proteins; Immunohistochemistry; Kainic Acid; Levetiracetam; Neurons; Nootropic Agents; Piracetam; Rats; Seizures; Status Epilepticus; Tetanus Toxin; Time Factors; Tumor Suppressor Proteins | 2010 |
Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats.
Topics: Action Potentials; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 2010 |
The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.
Topics: Age Factors; Animals; Brain; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Recurrence; Rimonabant; Status Epilepticus | 2010 |
Kainic acid-induced seizures activate GSK-3β in the hippocampus of D2R-/- mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Enzyme Activation; Excitatory Amino Acid Agonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Nerve Degeneration; Proto-Oncogene Proteins c-akt; Receptors, Dopamine D2; Seizures; Signal Transduction | 2010 |
Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis.
Topics: Animals; Blotting, Western; Brain; Cyclophilin A; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Epilepsy; Gene Expression; Kainic Acid; Macrophage Migration-Inhibitory Factors; Male; Phytotherapy; Plant Extracts; Proteomics; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Uncaria; Up-Regulation | 2010 |
Kainate-induced toxicity in the hippocampus: potential role of lithium.
Topics: Animals; Calcium; Calpain; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glycogen Synthase Kinases; Hippocampus; Kainic Acid; Lithium Chloride; Male; Mice; Mice, Inbred Strains; Neurodegenerative Diseases; Neuroprotective Agents; Phosphorylation; tau Proteins | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Kainic Acid; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rotarod Performance Test; Seizures | 2010 |
Domoic acid induced seizures progress to a chronic state of epilepsy in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Epilepsy; Kainic Acid; Male; Marine Toxins; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures; Videotape Recording | 2011 |
Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electric Stimulation; Genetic Therapy; Genetic Vectors; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Protein Binding; Radiography; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neuropeptide Y; Seizures; Sulfur Isotopes; Transcription, Genetic | 2010 |
Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Disease Models, Animal; Estrous Cycle; Female; Incidence; Kainic Acid; Male; Methamphetamine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reaction Time; Seizures; Sex Factors | 2010 |
Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures.
Topics: Adenosine; Animals; Anticonvulsants; Catheterization; Disease Models, Animal; Drug Delivery Systems; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 2010 |
Protein kinase Cdelta is associated with 14-3-3 phosphorylation in seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Animals; bcl-Associated Death Protein; Caspase 3; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Phosphopyruvate Hydratase; Phosphorylation; Protein Kinase C-delta; Seizures; Serine | 2010 |
Changes in hippocampal GABAA/cBZR density during limbic epileptogenesis: relationship to cell loss and mossy fibre sprouting.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Neuronal Plasticity; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Recovery of Function; Status Epilepticus | 2011 |
Neuroprotective effects of leptin following kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Drug Interactions; Hippocampus; Kainic Acid; Leptin; Male; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2010 |
Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy.
Topics: Animals; Botulinum Toxins; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calbindin 2; Cell Adhesion Molecules, Neuronal; Cell Count; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Extracellular Matrix Proteins; Hippocampus; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Tissue Proteins; Receptor, trkB; Reelin Protein; S100 Calcium Binding Protein G; Serine Endopeptidases; Synaptic Transmission | 2011 |
Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Neurons; Neurosurgical Procedures; Seizures | 2011 |
Effect of sex differences and gonadal hormones on kainic acid-induced neurodegeneration in the bed nucleus of the stria terminalis of the rat.
Topics: Animals; Behavior, Animal; Castration; Diestrus; Disease Models, Animal; Estrogens; Excitatory Amino Acid Agonists; Female; Gonadal Hormones; Injections, Intraperitoneal; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Septal Nuclei; Sex Factors; Status Epilepticus; Testosterone | 2012 |
Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid.
Topics: Animals; Aspirin; Cell Survival; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Administration Schedule; Hippocampus; Indans; Kainic Acid; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neurons; Neurotoxins | 2011 |
Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model.
Topics: Animals; Antioxidants; Arginase; Argininosuccinate Lyase; Argininosuccinate Synthase; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Citrulline; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2011 |
BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Protein; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Inbred F344 | 2011 |
Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation.
Topics: Animals; Brain Mapping; Deep Brain Stimulation; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Poisson Distribution; Rats; Rats, Wistar; Signal Processing, Computer-Assisted; Status Epilepticus | 2010 |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
Topics: Aminopeptidases; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Lectins, C-Type; Male; Neurotoxins; Pancreatitis-Associated Proteins; Rats; Rats, Wistar; Seizures; Temporal Lobe | 2011 |
Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Computer Simulation; Disease Models, Animal; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Models, Biological; Time Factors | 2010 |
Altered social interaction in adult rats following neonatal treatment with domoic acid.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Critical Period, Psychological; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Schizophrenia; Social Behavior | 2011 |
Chronic electrographic seizure reduces glutamine and elevates glutamate in the extracellular fluid of rat brain.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Extracellular Fluid; Glutamic Acid; Glutamine; Hippocampus; Intracellular Fluid; Kainic Acid; Male; Microdialysis; Neurotoxins; Rats; Rats, Wistar; Synaptic Vesicles | 2011 |
Proliferation changes in dentate gyrus of hippocampus during the first week following kainic acid-induced seizures.
Topics: Animals; Antibodies; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neuronal Plasticity; Neuropeptides; Seizures; Staining and Labeling; Time Factors | 2010 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Agonists; Hippocampus; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Muscimol; N-Methylaspartate; Neurons; Statistics, Nonparametric; Time Factors; Wakefulness | 2010 |
Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Caspase 3; Cell Line, Tumor; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Humans; Kainic Acid; Male; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Ubiquitin | 2011 |
Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration.
Topics: Animals; CA1 Region, Hippocampal; Cation Transport Proteins; Cell Death; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Fluoresceins; Gene Expression Regulation, Viral; Green Fluorescent Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Organic Chemicals; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Seizures; Video Recording; Zinc | 2011 |
Myelin-associated glycoprotein protects neurons from excitotoxicity.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Disease Susceptibility; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Vitro Techniques; Integrin beta Chains; Kainic Acid; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin Proteins; Myelin-Associated Glycoprotein; N-Methylaspartate; Neurons; Peptide Fragments; Phosphoinositide Phospholipase C; Receptors, Cell Surface; Seizures; Signal Transduction; Tubulin | 2011 |
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Inflammation; Kainic Acid; Male; Nicotinic Acids; Pain; Phosphoserine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2011 |
Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Topics: Animals; Anticonvulsants; Bicuculline; Chi-Square Distribution; Disease Models, Animal; Dose-Response Relationship, Drug; Fabaceae; Flowers; Heterocyclic Compounds, 4 or More Rings; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Reaction Time; Seizures | 2011 |
Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Catecholamines; Chromatography, High Pressure Liquid; Chronobiology Disorders; Circadian Rhythm; Depression; Disease Models, Animal; Epilepsy, Temporal Lobe; Escape Reaction; Hippocampus; Kainic Acid; Male; Maze Learning; Rats; Rats, Inbred SHR; Rats, Wistar; Statistics, Nonparametric; Sucrose; Swimming; Time Factors | 2011 |
Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biotinylation; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Freund's Adjuvant; In Vitro Techniques; Inflammation; Kainic Acid; Male; Microscopy, Immunoelectron; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Receptors, AMPA; Spinal Cord | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Hypertension; Kainic Acid; Muscimol; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred SHR; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate | 2011 |
Peripheral immune challenge with dsRNA enhances kainic acid-induced status epilepticus.
Topics: Animals; Brain; Disease Models, Animal; Female; Kainic Acid; Mice; Mice, Inbred C57BL; Poly I-C; RNA, Double-Stranded; Seizures; Status Epilepticus | 2011 |
Kainate administered to adult zebrafish causes seizures similar to those in rodent models.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Quinoxalines; Rats; Receptors, Glutamate; Seizures; Zebrafish | 2011 |
Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats.
Topics: Administration, Oral; Animals; Blotting, Western; Cell Death; Cell Proliferation; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Growth Factors; Neuroglia; Plant Extracts; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Uncaria | 2011 |
Nuclear factor-kappa B activity regulates brain expression of P-glycoprotein in the kainic acid-induced seizure rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Disease Susceptibility; Kainic Acid; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Seizures; Transcription Factor RelA | 2011 |
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.
Topics: Adaptive Immunity; Analysis of Variance; Animals; Biomarkers; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Immunity, Innate; Immunohistochemistry; Intercellular Adhesion Molecule-1; Kainic Acid; Leukocyte Common Antigens; Leukocyte Count; Leukocytes; Male; Mice; Mice, Knockout; Microglia; Neurons; Sclerosis | 2011 |
Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Caffeic Acids; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Galantamine; Glutathione; Hippocampus; Kainic Acid; Lactones; Lipid Peroxidation; Maze Learning; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Nootropic Agents; Rats; Rats, Wistar; Succinate Dehydrogenase; Sulfones; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2011 |
Decrease of calbindin-d28k, calretinin, and parvalbumin by taurine treatment does not induce a major susceptibility to kainic acid.
Topics: Animals; Calbindin 1; Calbindin 2; Calbindins; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; Down-Regulation; Drug Resistance; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurotoxins; Parvalbumins; S100 Calcium Binding Protein G; Taurine | 2011 |
Increased expression of acyl-coenzyme A: cholesterol acyltransferase-1 and elevated cholesteryl esters in the hippocampus after excitotoxic injury.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cell Line, Transformed; Cholesterol; Cholesterol Esters; Disease Models, Animal; Excitatory Amino Acid Agonists; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Neurotoxicity Syndromes; Oligodendroglia; Rats; Rats, Wistar; RNA, Messenger; Sterol O-Acyltransferase | 2011 |
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Functional Laterality; Hippocampus; Kainic Acid; Luminescent Proteins; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; Neurogenesis; Neuropeptides; Patch-Clamp Techniques; Picrotoxin | 2012 |
Effect of neuronal excitotoxicity on Munc18-1 distribution in nuclei of rat hippocampal neuron and primary cultured neuron.
Topics: Animals; Cell Nucleus; Cells, Cultured; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred Strains; Munc18 Proteins; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley | 2011 |
Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.
Topics: Animals; Calbindin 2; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Functional Laterality; Gene Expression Regulation; Hippocampus; Indoles; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphotransferases; Receptors, AMPA; S100 Calcium Binding Protein G; Stereotaxic Techniques; Synaptophysin | 2011 |
Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury.
Topics: Acute Disease; Animals; Cell Death; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Neurotoxins; Oxidative Stress; Proteomics; Rats; Rats, Wistar; Status Epilepticus | 2011 |
Ischemic cardiomyopathy following seizure induction by domoic Acid.
Topics: Animals; Behavior, Animal; Cardiomyopathies; Cytokines; Disease Models, Animal; Kainic Acid; Male; Mitochondria; Myocardial Ischemia; Neuromuscular Depolarizing Agents; Rats; Rats, Sprague-Dawley; Respiration; Seizures; Ventricular Dysfunction, Left | 2011 |
Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention.
Topics: Alcohols; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Behavior, Animal; Biomarkers; Brain; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Injections, Intraperitoneal; Kainic Acid; Male; Neuroprotective Agents; Oxidative Stress; Phyllanthus emblica; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Reaction Time; Solvents; Status Epilepticus; Time Factors | 2011 |
IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Insulin-Like Growth Factor I; Kainic Acid; Male; Maze Learning; Memory; Mice; Nerve Degeneration; Neurogenesis; Neurons | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Reaction Time; Seizures; Spider Venoms; Synaptosomes; Tritium | 2011 |
Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dopamine; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Kainic Acid; Male; Oxcarbazepine; Rats; Rats, Wistar; Seizures; Serotonin; Sleep Stages | 2011 |
Nicotine reversal of anticonvulsant action of topiramate in kainic acid-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Fructose; Humans; Kainic Acid; Lipid Peroxidation; Male; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic; Seizures; Topiramate | 2011 |
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Therapy, Combination; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Hyperalgesia; Kainic Acid; Pain Threshold; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Riluzole; Spinal Cord; Up-Regulation; Valproic Acid | 2011 |
Spadin as a new antidepressant: absence of TREK-1-related side effects.
Topics: Animals; Antidepressive Agents; Biophysical Phenomena; Blood Glucose; Brain Infarction; CD8 Antigens; Cell Line, Transformed; Chlorocebus aethiops; Convulsants; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Eating; Electric Stimulation; Green Fluorescent Proteins; Hindlimb Suspension; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Potassium Channels; Potassium Channels, Tandem Pore Domain; Seizures; Swimming; Transfection | 2012 |
Protective effect of 2,2'-dithienyl diselenide on kainic acid-induced neurotoxicity in rat hippocampus.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Glutathione Peroxidase; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Organoselenium Compounds; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Reaction Time; Seizures; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Thiophenes; Thymidine; Trityl Compounds | 2011 |
Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Learning; Magnetic Resonance Imaging; Male; Maze Learning; Memory Disorders; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spatial Behavior | 2011 |
Domoic acid induced status epilepticus promotes aggressive behavior in rats.
Topics: Aggression; Animals; Disease Models, Animal; Emotions; Kainic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Status Epilepticus; Stress, Psychological; Time Factors | 2012 |
Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus.
Topics: Animals; Disease Models, Animal; Ghrelin; Kainic Acid; Male; Oligopeptides; Peptides; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2011 |
Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals.
Topics: Acetylcholine; Alzheimer Disease; Animals; Astrocytes; CA3 Region, Hippocampal; Choline O-Acetyltransferase; Cognition Disorders; Disease Models, Animal; Humans; Kainic Acid; Learning; Male; Memory Disorders; Neural Stem Cells; Neurogenesis; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2012 |
Functional changes in the septal GABAergic system of animals with a model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Kainic Acid; Models, Biological; Neurons; Oscillometry; Receptors, GABA-A; Receptors, GABA-B | 2011 |
Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Eicosanoids; Epilepsy, Temporal Lobe; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Plant Lectins; RNA, Messenger; Seizures; Signal Transduction; Time Factors | 2011 |
Automatic detection of epileptic seizures on the intra-cranial electroencephalogram of rats using reservoir computing.
Topics: Algorithms; Animals; Automation; Brain; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Neural Networks, Computer; Pattern Recognition, Automated; Predictive Value of Tests; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Time Factors | 2011 |
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
Topics: Adenosine; Adenosine Kinase; Amygdala; Animals; Disease Models, Animal; Electroencephalography; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Seizures; Time Factors | 2012 |
Aquaporin-4-dependent edema clearance following status epilepticus.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Mapping; Cerebral Cortex; Disease Models, Animal; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Status Epilepticus; Time Factors; Water | 2012 |
A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Food, Formulated; Kainic Acid; Male; Pharmaceutical Preparations; Rats; Seizures; Status Epilepticus; Time Factors; Treatment Outcome | 2012 |
Habenula regulates cardiovascular activities in the insula cortex in a rat model of epilepsy.
Topics: Animals; Behavior, Animal; Blood Pressure; Cerebral Cortex; Disease Models, Animal; Epilepsy; Habenula; Heart Rate; Kainic Acid; Norepinephrine; Rats; Rats, Wistar | 2012 |
Stress and corticosteroid modulation of seizures and synaptic inhibition in the hippocampus.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biophysics; Disease Models, Animal; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Male; Mifepristone; Mineralocorticoid Receptor Antagonists; Neural Inhibition; Patch-Clamp Techniques; Rats; Rats, Wistar; Reaction Time; Seizures; Spironolactone; Stress, Psychological; Synapses; Time Factors | 2012 |
Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Matrix Metalloproteinase 7; Nerve Degeneration; Nerve Growth Factors; Neuroprotective Agents; Organ Culture Techniques; Protein Precursors; Rats; Rats, Sprague-Dawley | 2012 |
Epileptic seizure detection with the local field potential of anterior thalamic of rats aiming at real time application.
Topics: Algorithms; Animals; Deep Brain Stimulation; Disease Models, Animal; Electric Power Supplies; Electrodes; Electroencephalography; Epilepsy, Temporal Lobe; Equipment and Supplies; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures; Thalamus | 2011 |
Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cricetinae; Cricetulus; Disease Models, Animal; Electroencephalography; Fluoresceins; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Models, Biological; Nerve Tissue Proteins; Organic Chemicals; Phenylisopropyladenosine; Receptor, Adenosine A1; RGS Proteins; Seizures; Signal Transduction; Sulfonamides; Time Factors; Transfection; Xanthines | 2012 |
Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia.
Topics: Amygdala; Animals; Bipolar Disorder; Brain Mapping; CA2 Region, Hippocampal; Disease Models, Animal; Electrophysiology; Hippocampus; Interneurons; Kainic Acid; Male; Oscillometry; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Schizophrenia; Signal Transduction | 2012 |
The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy.
Topics: Animals; Antidepressive Agents; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Kainic Acid; Male; Morpholines; Rats; Rats, Sprague-Dawley; Reboxetine; Seizures; Status Epilepticus; Time Factors; Treatment Outcome; Video Recording | 2012 |
Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Cerebral Arteries; Disease Models, Animal; Disease Progression; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Laminin; Male; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Time Factors; Up-Regulation | 2012 |
Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Axons; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Kainic Acid; Long-Term Potentiation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mossy Fibers, Hippocampal; Neurons; Neuropsychological Tests; Patch-Clamp Techniques; Post-Synaptic Density; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Recognition, Psychology; Silver Staining; Status Epilepticus | 2012 |
Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis.
Topics: Animals; Bacterial Proteins; Calbindin 2; Carrier Proteins; Cation Transport Proteins; Cell Count; Dendrites; Disease Models, Animal; Epilepsy; Functional Laterality; Hippocampus; Kainic Acid; Ki-67 Antigen; Luminescent Proteins; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Mossy Fibers, Hippocampal; Neurons; Phosphopyruvate Hydratase; S100 Calcium Binding Protein G | 2012 |
Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function.
Topics: Animals; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Female; Glutamic Acid; Kainic Acid; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Pregnancy | 2012 |
Prolonged generalized dystonia after chronic cerebellar application of kainic acid.
Topics: Animals; Brain; Cerebellum; Disease Models, Animal; Dystonia; Enkephalins; HSP72 Heat-Shock Proteins; Kainic Acid; Neurons; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats | 2012 |
Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions.
Topics: Acoustic Stimulation; Action Potentials; Animals; Audiometry, Evoked Response; Cochlea; Cochlear Nerve; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Male; Organ of Corti; Perfusion; Perilymph; Rats; Rats, Long-Evans; Reaction Time | 2012 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agonists; Kainic Acid; Lithium; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2012 |
Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE.
Topics: Analysis of Variance; Animals; Atrophy; Brain Mapping; CA1 Region, Hippocampal; Disease Models, Animal; Disease Progression; Electroencephalography; Electron Transport Complex IV; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluorodeoxyglucose F18; Glial Fibrillary Acidic Protein; Glucose Metabolism Disorders; Glucose Transporter Type 1; Kainic Acid; Limbic System; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Pyramidal Cells; Rats; Rats, Wistar; Synaptophysin; Time Factors | 2012 |
Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures.
Topics: Action Potentials; Animals; Brain; Brain Mapping; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Magnetic Resonance Imaging; Male; Oxygen; Rats; Rats, Wistar; Seizures; Wakefulness | 2012 |
Changes in interictal spike features precede the onset of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Brain Mapping; Brain Waves; Disease Models, Animal; Electrodes; Electroencephalography; Kainic Acid; Male; Nonlinear Dynamics; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Time Factors | 2012 |
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.
Topics: Animals; Anticonvulsants; Astrocytes; Diazepam; Disease Models, Animal; Drug Resistance; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Marine Toxins; Microglia; Nerve Degeneration; Neurogenesis; Neurons; Organ Specificity; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Status Epilepticus; Time Factors | 2012 |
Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia.
Topics: Analysis of Variance; Anhedonia; Animals; Astrocytes; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Electromyography; Excitatory Amino Acid Agonists; Food Preferences; Glutamic Acid; Kainic Acid; Male; Prefrontal Cortex; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Self Stimulation; Sucrose | 2012 |
Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy.
Topics: Adult; Animals; Astrocytes; Case-Control Studies; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Immunoenzyme Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Middle Aged; Neurons; Sclerosis; Seizures; Signal Transduction; TOR Serine-Threonine Kinases; Young Adult | 2012 |
Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus.
Topics: Acupuncture Therapy; Animals; Apoptosis; Cytokines; Disease Models, Animal; Encephalitis; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Seizures | 2012 |
Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Male; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Spectrin; Ubiquitin Thiolesterase; Up-Regulation | 2012 |
Ketogenic diet reduces Smac/Diablo and cytochrome c release and attenuates neuronal death in a mouse model of limbic epilepsy.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Carrier Proteins; Caspase 3; Caspase 9; Cell Death; Cytochromes c; Diet, Ketogenic; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Neurons | 2012 |
IL-1β induction and IL-6 suppression are associated with aggravated neuronal damage in a lipopolysaccharide-pretreated kainic acid-induced rat pup seizure model.
Topics: Animals; Animals, Newborn; Body Temperature; Brain Injuries; Cytokines; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Hippocampus; Interleukin-1beta; Interleukin-6; Kainic Acid; Lipopolysaccharides; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Statistics, Nonparametric; Status Epilepticus; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
A cupric silver histochemical analysis of domoic acid damage to olfactory pathways following status epilepticus in a rat model for chronic recurrent spontaneous seizures and aggressive behavior.
Topics: Aggression; Animals; Brain; Copper; Disease Models, Animal; Histocytochemistry; Kainic Acid; Male; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Silver Compounds; Silver Staining; Status Epilepticus | 2013 |
The effects of glycemic control on seizures and seizure-induced excitotoxic cell death.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Fasting; Glucose; Hippocampus; Hyperglycemia; Hypoglycemia; Insulin; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxins; Phosphopyruvate Hydratase; Status Epilepticus; Streptozocin | 2012 |
Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis.
Topics: Analysis of Variance; Animals; Arginine; Biotinylation; Brain; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex IV; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mitochondria; Models, Molecular; Molecular Weight; Oxidative Stress; Peptide Mapping; Protein Carbonylation; Protein Processing, Post-Translational; Protein Subunits; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Status Epilepticus; Synaptosomes; Time Factors | 2012 |
Stimulation of the anterior nucleus of the thalamus induces changes in amino acids in the hippocampi of epileptic rats.
Topics: Amino Acids; Analysis of Variance; Animals; Anterior Thalamic Nuclei; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Functional Laterality; Hippocampus; Kainic Acid; Male; Microdialysis; Neural Pathways; Rats; Rats, Wistar; Time Factors | 2012 |
TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury.
Topics: Age Factors; Animals; Calcium; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agents; Female; Isoquinolines; Kainic Acid; Motor Neurons; Neurofilament Proteins; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spinal Cord; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
Topics: Animals; Arginine; Brain Waves; Dentate Gyrus; Diazepam; Disease Models, Animal; Gliosis; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fos; Seizures; Status Epilepticus; Synapses; Synaptophysin; Telemetry | 2012 |
Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus.
Topics: Animals; Antigens, CD; Disease Models, Animal; Encephalitis; Excitatory Amino Acid Agonists; Hippocampus; Interleukin-4; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred Strains; Microglia; Nerve Degeneration; Primary Cell Culture; Rats; Rats, Sprague-Dawley | 2012 |
Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus.
Topics: Adult Stem Cells; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression; Genes, Reporter; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Notch1; Repressor Proteins; Signal Transduction; SOXB1 Transcription Factors; Status Epilepticus; Stem Cell Niche | 2012 |
Neonatal domoic acid treatment produces alterations to prepulse inhibition and latent inhibition in adult rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Schizophrenia | 2012 |
The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Green Fluorescent Proteins; Immunohistochemistry; Kainic Acid; Limbic System; Long-Term Potentiation; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pilocarpine; Protein-Tyrosine Kinases; Pyramidal Cells; Status Epilepticus; Synapses | 2013 |
A guinea pig model of mesial temporal lobe epilepsy following nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Guinea Pigs; Hippocampus; Kainic Acid; Male; Status Epilepticus | 2012 |
Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Malondialdehyde; Mossy Fibers, Hippocampal; Neuroprotective Agents; Nitrites; Oxidative Stress; Rats; Status Epilepticus; Ubiquinone; Vitamins | 2013 |
Aquaporin-4 deficiency attenuates opioid dependence through suppressing glutamate transporter-1 down-regulation and maintaining glutamate homeostasis.
Topics: Animals; Aquaporin 4; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Homeostasis; Kainic Acid; Mice; Mice, Knockout; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Tritium | 2013 |
Insulin growth factor-I promotes functional recovery after a focal lesion in the dentate gyrus.
Topics: Animals; Astrocytes; Behavior, Animal; Brain Damage, Chronic; Dendrites; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Fear; Glial Fibrillary Acidic Protein; Infusions, Intraventricular; Insulin-Like Growth Factor I; Kainic Acid; Male; Memory Disorders; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurogenesis; Neuronal Plasticity; Neurons; Neuropeptides; Nootropic Agents; Rats; Rats, Wistar | 2012 |
Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage.
Topics: Administration, Topical; Animals; Antimycin A; Apoptosis; Caspase 3; Caspase 7; Cell Count; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Cornea; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Ophthalmic Solutions; Rabbits; Rats; Rats, Wistar; Retina; Retinal Diseases; Retinal Ganglion Cells; Time Factors; Ubiquinone; Vitamins | 2012 |
Lack of resveratrol neuroprotection in developing rats treated with kainic acid.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Brain Waves; Cell Count; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Developmental; Hippocampus; Kainic Acid; Lipid Peroxidation; Male; Malondialdehyde; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Resveratrol; Status Epilepticus; Stilbenes | 2013 |
The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Hyperkinesis; Kainic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2013 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
Depletion of polysialic acid from neural cell adhesion molecule (PSA-NCAM) increases CA3 dendritic arborization and increases vulnerability to excitotoxicity.
Topics: Analysis of Variance; Animals; Body Mass Index; CA3 Region, Hippocampal; Dendrites; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Gene Expression Regulation; Kainic Acid; Male; Metalloendopeptidases; Nerve Degeneration; Neural Cell Adhesion Molecules; Organic Chemicals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sialic Acids; Silver Staining; Stress, Psychological | 2013 |
Manganese-enhanced MRI reflects seizure outcome in a model for mesial temporal lobe epilepsy.
Topics: Animals; Contrast Media; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Image Interpretation, Computer-Assisted; Kainic Acid; Magnetic Resonance Imaging; Male; Manganese; Rats; Rats, Wistar; Seizures | 2013 |
Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Disease Susceptibility; Disks Large Homolog 4 Protein; Excitatory Postsynaptic Potentials; Gene Knock-In Techniques; Guanylate Kinases; Hippocampus; Humans; Hypoxia; Kainic Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Phosphorylation; Receptors, AMPA; Seizures; Serine | 2012 |
Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Waves; Disease Models, Animal; Excitatory Amino Acid Agonists; GABA-A Receptor Antagonists; Hippocampus; Kainic Acid; Methyl-CpG-Binding Protein 2; Mice; Nerve Net; Neurons; Potassium Channel Blockers; Rett Syndrome; Seizures | 2013 |
Urokinase-type plasminogen activator receptor modulates epileptogenesis in mouse model of temporal lobe epilepsy.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Body Temperature; Cell Movement; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Epilepsy, Temporal Lobe; Genotype; Inflammation; Kainic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mossy Fibers, Hippocampal; Nerve Degeneration; Neurogenesis; Neuropeptides; Receptors, Urokinase Plasminogen Activator; Status Epilepticus; Survival Analysis; T-Lymphocytes | 2013 |
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.
Topics: Amyloid beta-Protein Precursor; Animals; Base Sequence; Cell Survival; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Humans; Interleukins; Kainic Acid; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Phosphorylation; Prosencephalon; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction | 2013 |
fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Depression; Disease Models, Animal; Doublecortin Domain Proteins; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microarray Analysis; Microtubule-Associated Proteins; Mutation; Neurogenesis; Neuropeptides; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos | 2013 |
Neonatal immune challenge exacerbates seizure-induced hippocampus-dependent memory impairment in adult rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Cytokines; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Maze Learning; Memory Disorders; Minocycline; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors; Up-Regulation | 2013 |
Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy.
Topics: Animals; Aquaporin 4; Astrocytes; Cell Polarity; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2013 |
Relations between brain pathology and temporal lobe epilepsy.
Topics: Animals; Brain; Cell Death; Cell Survival; Chronic Disease; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Kainic Acid; Limbic System; Male; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Rats; Rats, Inbred F344; Rats, Wistar; Reaction Time; Recurrence; Survival Rate | 2002 |
Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Ibotenic Acid; Injections; Kainic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Abnormal cerebellar signaling induces dystonia in mice.
Topics: Action Potentials; Animals; Behavior, Animal; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microinjections; Organ Specificity; Posture; Proto-Oncogene Proteins c-fos; Purkinje Cells; Reproducibility of Results; RNA, Messenger; Severity of Illness Index; Synaptic Transmission | 2002 |
Cerebral distribution of polyamines in kainic acid-induced models of status epilepticus and ataxia in rats. Overproduction of putrescine and histological damage.
Topics: Analysis of Variance; Animals; Ataxia; Biogenic Polyamines; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Motor Activity; Putrescine; Rats; Rats, Wistar; Spermidine; Spermine; Status Epilepticus | 2002 |
Glial expression of estrogen and androgen receptors after rat brain injury.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Disease Models, Animal; Estrogen Receptor alpha; Estrogen Receptor beta; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Lectins; Male; Microglia; Nerve Degeneration; Nerve Regeneration; Neuroglia; Plant Lectins; Rats; Rats, Wistar; Receptors, Androgen; Receptors, Estrogen; Vimentin | 2002 |
Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Death; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Laser-Doppler Flowmetry; Limbic System; Male; Mice; Mice, Inbred C57BL; Neurons | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus | 2002 |
Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Active Transport, Cell Nucleus; Amygdala; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Cell Death; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Microinjections; Mitochondria; Neurons; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Tyrosine 3-Monooxygenase | 2002 |
Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy.
Topics: Animals; Bromodeoxyuridine; Cell Death; Cell Division; Disease Models, Animal; DNA Fragmentation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Injections, Intraperitoneal; Kainic Acid; Kindling, Neurologic; Male; Microglia; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Stem Cells; Time Factors | 2002 |
Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Disease Models, Animal; Endothelium, Vascular; Epilepsy, Temporal Lobe; Female; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Rats; Time Factors | 2002 |
Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases of the Nervous System; Biomarkers; Brain Chemistry; Citrulline; Disease Models, Animal; Docosahexaenoic Acids; F2-Isoprostanes; Immunity, Innate; Isoprostanes; Kainic Acid; Lipid Peroxidation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oxidation-Reduction; Oxidative Stress; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype | 2002 |
Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures.
Topics: Animals; Benzimidazoles; Binding, Competitive; Brain; Cell Membrane; Disease Models, Animal; Hippocampus; Homozygote; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Organ Specificity; Piperidines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Seizures; Thalamus | 2002 |
Synaptotagmin I hypothalamic knockdown prevents amygdaloid seizure-induced damage of hippocampal neurons but not of entorhinal neurons.
Topics: Amygdala; Animals; Calcium-Binding Proteins; Disease Models, Animal; Down-Regulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Hypothalamus; Kainic Acid; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Neural Pathways; Neurons; Oligonucleotides, Antisense; Rats; Rats, Wistar; Synaptic Transmission; Synaptotagmin I; Synaptotagmins | 2002 |
Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain.
Topics: Adenosine Triphosphate; Animals; Brain; Cell Death; Citrulline; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Kainic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitrogen Oxides; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Status Epilepticus; Up-Regulation; Vitamin E | 2002 |
Obesity exacerbates chemically induced neurodegeneration.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Dopamine; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Ion Channels; Kainic Acid; Membrane Transport Proteins; Methamphetamine; Mice; Mice, Obese; Microtubule-Associated Proteins; Mitochondrial Proteins; Neostriatum; Neurodegenerative Diseases; Neurons; Neurotoxicity Syndromes; Neurotoxins; Obesity; Presynaptic Terminals; Proteins; Uncoupling Protein 2 | 2002 |
Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Proto-Oncogene Proteins c-fos; Rats; Rats, Mutant Strains; Receptors, AMPA; RNA, Messenger; Seizures; Synapses | 2002 |
GnRH-immunoreactive fiber changes with unilateral amygdala-kindled seizures.
Topics: Amygdala; Animals; Disease Models, Animal; Female; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2002 |
Neuroprotective effect of GMP in hippocampal slices submitted to an in vitro model of ischemia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Survival; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guanosine Monophosphate; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Glutamate; Synaptic Transmission | 2002 |
Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunction.
Topics: Acute Disease; Animals; Calcium; Calcium-Transporting ATPases; Cation Transport Proteins; Culture Techniques; Disease Models, Animal; Electron Transport Complex IV; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; In Situ Hybridization; Kainic Acid; Multiple Sclerosis; Oligonucleotide Array Sequence Analysis; Plasma Membrane Calcium-Transporting ATPases; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Channels; Spinal Cord | 2003 |
Increased dendritic excitability in hippocampal ca1 in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis.
Topics: Action Potentials; Animals; Bicuculline; Dendrites; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Kainic Acid; Male; Neural Inhibition; Neural Pathways; Perforant Pathway; Rats; Rats, Long-Evans; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2003 |
Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats.
Topics: Aging; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Telencephalon | 2003 |
Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration.
Topics: Animals; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolytic Agents; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Plasminogen Activators; Tissue Plasminogen Activator | 2003 |
Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.
Topics: Age Factors; Animals; Apoptosis; Ceramides; Disease Models, Animal; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sphingosine; Status Epilepticus | 2003 |
Increased mu-opioid receptor labeling is found on inner molecular layer terminals of the dentate gyrus following seizures.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Enkephalins; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Seizures | 2003 |
Vagal afferents are necessary for the establishment but not the maintenance of kainic acid-induced hyperalgesia in mice.
Topics: Animals; Brain; Cell Count; Cell Death; Chronic Disease; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Neurons, Afferent; Nodose Ganglion; Oncogene Proteins v-fos; Pain Measurement; Spinal Cord; Vagotomy; Vagus Nerve | 2003 |
Lead can inhibit NMDA-, K(+)-, QA/KA-induced increases in intracellular free Ca2+ in cultured rat hippocampal neurons.
Topics: Animals; Calcium; Cognition Disorders; Disease Models, Animal; Hippocampus; Kainic Acid; Lead; Learning Disabilities; Microscopy, Confocal; N-Methylaspartate; Neurons; Potassium; Quisqualic Acid; Rats; Rats, Wistar | 2002 |
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Epilepsy; Genetic Vectors; Heat-Shock Proteins; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Simplexvirus; Stress, Physiological; Treatment Outcome | 2003 |
Activity-induced and developmental downregulation of the Nogo receptor.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Ganglia, Spinal; GPI-Linked Proteins; Higher Nervous Activity; Hippocampus; Kainic Acid; Learning; Male; Motor Activity; Myelin Proteins; Neuronal Plasticity; Nogo Proteins; Nogo Receptor 1; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Peptide; RNA, Messenger; Spinal Cord; Spinal Cord Injuries | 2003 |
Differences in ionotropic glutamate receptor subunit expression are not responsible for strain-dependent susceptibility to excitotoxin-induced injury.
Topics: Animals; Cell Death; Disease Models, Animal; Drug Resistance; Epilepsy; Genetic Predisposition to Disease; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurotoxins; Protein Subunits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Species Specificity; Synaptic Transmission | 2003 |
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Central Nervous System; Central Nervous System Diseases; Central Nervous System Viral Diseases; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Genetic Vectors; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neurons; Neurotoxins; Protein Structure, Tertiary; Sindbis Virus; Stroke; Synaptic Transmission | 2003 |
Down-regulation of GABA-transporter function by hippocampal translation products: its possible role in epilepsy.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mice; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; RNA, Complementary; RNA, Messenger; Tritium; Xenopus laevis | 2003 |
N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy.
Topics: Animals; Cell Death; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; DNA Fragmentation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Limbic System; Mediodorsal Thalamic Nucleus; Nerve Degeneration; Neurons; Neuroprotective Agents; Olfactory Pathways; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Treatment Outcome | 2003 |
Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures.
Topics: Animals; Animals, Newborn; Cell Death; Cell Division; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Membrane Potentials; Mossy Fibers, Hippocampal; Neural Pathways; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Seizures, Febrile; Synaptic Transmission | 2003 |
Convulsive and postural effects of lesioning the mid-substantia nigra pars reticulata in naïve and 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cortical Synchronization; Disease Models, Animal; Dopamine Agonists; Female; Functional Laterality; Kainic Acid; Motor Activity; Oxidopamine; Parkinsonian Disorders; Perceptual Disorders; Posture; Rats; Rats, Sprague-Dawley; Rotation; Seizures; Substantia Nigra | 2003 |
Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Modulators; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; GABA Antagonists; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Limbic System; Mice; Mice, Knockout; Neurons; Neurotoxins; Polyunsaturated Alkamides; Seizures | 2003 |
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Behavior, Animal; Calcium; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Forelimb; Glycine; Hand Strength; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Psychomotor Performance; Quinoxalines; Receptors, AMPA | 2003 |
The ability of new non-competitive glutamate receptor blockers to weaken motor disorders in animals.
Topics: Animals; Ataxia; Behavior, Animal; Catalepsy; Diamines; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Kainic Acid; Memantine; Mice; Mice, Inbred Strains; N-Methylaspartate; Quaternary Ammonium Compounds; Seizures; Structure-Activity Relationship; Time Factors | 2003 |
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.
Topics: Animals; Atropine; Basal Ganglia; Basal Ganglia Diseases; Bicuculline; Brain Stem; Cats; Choline O-Acetyltransferase; Disease Models, Animal; Efferent Pathways; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Excitatory Amino Acid Agonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Locomotion; Muscarinic Antagonists; Muscimol; Muscle Tonus; N-Methylaspartate; Neural Inhibition; Picrotoxin; Stimulation, Chemical | 2003 |
In vivo modulation of hippocampal epileptiform activity with radial electric fields.
Topics: Amplifiers, Electronic; Animals; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; Electrodes, Implanted; Electronics, Medical; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; Membrane Potentials; Microelectrodes; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques | 2003 |
[Effects of basic fibroblast growth factor on rat models of Alzheimer disease].
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Disease Models, Animal; Fibroblast Growth Factor 2; Kainic Acid; Learning; Male; Memory; Rats; Rats, Sprague-Dawley | 2003 |
GAP-43 mRNA and protein expression in the hippocampal and parahippocampal region during the course of epileptogenesis in rats.
Topics: Animals; Disease Models, Animal; Drosophila Proteins; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; GAP-43 Protein; Gene Expression Regulation; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Ligases; Male; Nerve Tissue Proteins; Parahippocampal Gyrus; Rats; Rats, Sprague-Dawley; RNA, Messenger; Silver Staining; Status Epilepticus; Time Factors; Ubiquitin-Protein Ligases | 2003 |
Ovarian steroid modulation of seizure severity and hippocampal cell death after kainic acid treatment.
Topics: Animals; Biomarkers; Cell Count; Cell Death; Disease Models, Animal; Drug Implants; Estradiol; Female; Hippocampus; Kainic Acid; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Survival Rate | 2003 |
Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Injections; Kainic Acid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Temporal Lobe | 2003 |
Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.
Topics: Action Potentials; Animals; Diffusion Chambers, Culture; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Male; Neural Inhibition; Patch-Clamp Techniques; Pentobarbital; Perfusion; Periodicity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2003 |
Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Progression; Down-Regulation; Dynorphins; Enkephalins; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Opioid Peptides; Rats; Rats, Wistar; Reaction Time; Status Epilepticus | 2003 |
Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures.
Topics: Adult; Animals; Antibody Specificity; Blotting, Northern; Cells, Cultured; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Kainic Acid; Limbic System; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Neurons; Phosphate Transport Proteins; Rats; RNA, Messenger; Seizures | 2003 |
Interaction of 14-3-3 with Bid during seizure-induced neuronal death.
Topics: 14-3-3 Proteins; Amygdala; Animals; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Casein Kinases; Cytochrome c Group; Disease Models, Animal; Hippocampus; Kainic Acid; Male; Mitochondria; Neurons; Protein Binding; Protein Kinases; Rats; Seizures; Tyrosine 3-Monooxygenase | 2003 |
Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.
Topics: Amino Acid Transport System X-AG; Animals; Cell Line; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kainic Acid; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Symporters | 2003 |
Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures.
Topics: 14-3-3 Proteins; Adaptor Proteins, Signal Transducing; Amygdala; Animals; Antigens, CD; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Count; Cerebral Cortex; Death-Associated Protein Kinases; Disease Models, Animal; Electroencephalography; Enzyme Activation; Fas-Associated Death Domain Protein; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Seizures; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2003 |
Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor-2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Division; Disease Models, Animal; Epilepsy, Temporal Lobe; Fetus; Fibroblast Growth Factor 2; Graft Survival; Hippocampus; Kainic Acid; Male; Memory Disorders; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Phenotype; Rats; Rats, Inbred F344; Stem Cells | 2003 |
Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat.
Topics: Adrenergic Agents; Anesthetics, Local; Animals; Cold Temperature; Disease Models, Animal; Electricity; Excitatory Amino Acid Agonists; Female; Hindlimb; Hot Temperature; Hyperalgesia; Kainic Acid; Lidocaine; Mononeuropathies; Nerve Block; Oxidopamine; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reference Values; Somatosensory Cortex | 2003 |
Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.
Topics: Animals; Brain; Calcium-Binding Proteins; Densitometry; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Immunoblotting; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Protein Isoforms; Rats; Rats, Wistar; Synapses; Synaptic Membranes | 2003 |
Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Epilepsy; Ethacrynic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Injections, Intraventricular; Kainic Acid; Male; Mice; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-fos; Up-Regulation | 2003 |
Kainic acid lesion-induced nigral neuronal death.
Topics: Animals; Biopterins; Cell Death; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Functional Laterality; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Kainic Acid; Male; Neurons; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2003 |
Effect of gamma-hydroxybutyrate in two rat models of focal cerebral damage.
Topics: Animals; Apomorphine; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Kainic Acid; Learning; Male; Memory Disorders; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Sodium Oxybate | 2003 |
Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Growth Factor; Nerve Growth Factors; Neurotrophin 3; Rats; Rats, Inbred F344 | 2003 |
In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures.
Topics: Animals; Animals, Newborn; Chloride Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neural Pathways; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2003 |
Expression and activation of caspase 3 following status epilepticus in the rat.
Topics: Animals; Blotting, Western; Brain; Caspase 3; Caspases; Cell Count; Cell Death; Disease Models, Animal; Electric Stimulation; Enzyme Activation; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Neuroglia; Organic Chemicals; Peptide Fragments; Peptide Hydrolases; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2003 |
Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Blood Vessels; Cell Count; Cell Death; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Encephalitis; Excitatory Amino Acid Agonists; GABA Modulators; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Membrane Glycoproteins; Neuroglia; Neurons; Organ Culture Techniques; Phenanthrolines; Phenylmercury Compounds; Protease Inhibitors; Rats; Rats, Wistar; Seizures; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2003 |
Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Carrier Proteins; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; Genetic Predisposition to Disease; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nipecotic Acids; Pentylenetetrazole; Picrotoxin; Seizures | 2003 |
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
Topics: Animals; Apoptosis; Brain Infarction; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; HSP70 Heat-Shock Proteins; Ischemic Attack, Transient; Kainic Acid; Male; Mice; Mice, Transgenic; Neurons; Rats; Seizures | 2003 |
Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures.
Topics: Animals; Antigens, CD; Cytokine Receptor gp130; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; STAT1 Transcription Factor; STAT3 Transcription Factor; Status Epilepticus; Trans-Activators; Up-Regulation | 2003 |
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Topics: Animals; Carrier Proteins; Cell Membrane; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mossy Fibers, Hippocampal; Neurons; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2003 |
Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Neuropeptide Y; Receptors, GABA-B; Somatostatin; Time; Time Factors | 2003 |
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Gliosis; Hippocampus; Inflammation Mediators; Interleukin 1 Receptor Antagonist Protein; Kainic Acid; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Status Epilepticus; Up-Regulation | 2003 |
Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice.
Topics: Action Potentials; Animals; Causality; Cell Membrane; Disease Models, Animal; Disease Susceptibility; Electric Impedance; Encephalitis, Herpes Simplex; Epilepsy; Epilepsy, Temporal Lobe; Herpesvirus 1, Human; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Neural Pathways; Organ Culture Techniques; Pyramidal Cells; Viral Proteins | 2003 |
The dual response of protein kinase Fyn to neural trauma: early induction in neurons and delayed induction in reactive astrocytes.
Topics: Animals; Astrocytes; Blotting, Western; Brain Damage, Chronic; Cell Death; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Enzyme Induction; Kainic Acid; Male; Mice; Neurons; Organ Specificity; Perforant Pathway; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; RNA Probes; RNA, Messenger; Seizures | 2004 |
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Brain; Disease Models, Animal; Disease Progression; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Neurons; Tubercidin; Xanthines | 2004 |
Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters.
Topics: Animals; Biopsy; Brain; Disease Models, Animal; Electrophysiology; Epilepsy; Functional Laterality; Hippocampus; Kainic Acid; Male; Microelectrodes; Neurons; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA | 2004 |
Expression of B/K protein in the hippocampus of kainate-induced rat seizure model.
Topics: Animals; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Epilepsy; Excitatory Amino Acid Agonists; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microscopy, Electron; Molecular Chaperones; Nerve Tissue Proteins; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Stress, Physiological; Synaptotagmins; Up-Regulation | 2004 |
Latency to onset of status epilepticus determines molecular mechanisms of seizure-induced cell death.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Boron Compounds; Calpain; Caspase 3; Caspases; Deoxyribonucleases; Disease Models, Animal; DNA Fragmentation; Kainic Acid; Male; Necrosis; Nerve Degeneration; Proteins; Rats; Rats, Sprague-Dawley; Seizures; Spectrin; Status Epilepticus; Time | 2004 |
Anti-excitotoxic activity of trimetazidine in the retina.
Topics: Administration, Oral; Animals; Cell Line; Disease Models, Animal; Electroretinography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Guinea Pigs; Ischemia; Kainic Acid; Rats; Rats, Wistar; Retina; Retinal Diseases; Trimetazidine | 2004 |
Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hippocampus; Infarction, Middle Cerebral Artery; Kainic Acid; Lipase; Lipoprotein Lipase; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Reaction Time; RNA, Messenger; Up-Regulation | 2004 |
Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Burns; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Injections, Spinal; Kainic Acid; Motor Cortex; Pain; Pain Threshold; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spider Venoms | 2004 |
Enhancement of central dopaminergic activity in the kainate model of temporal lobe epilepsy: implication for the mechanism of epileptic psychosis.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electrochemistry; Epilepsy, Temporal Lobe; Haloperidol; In Vitro Techniques; Kainic Acid; Male; Methamphetamine; Microdialysis; Motor Activity; Psychotic Disorders; Rats; Rats, Sprague-Dawley | 2004 |
Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.
Topics: Animals; Dependovirus; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome | 2004 |
Kainic acid-induced naip expression in the hippocampus is blocked in mice lacking TNF receptors.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Nerve Degeneration; Nerve Tissue Proteins; Neuronal Apoptosis-Inhibitory Protein; Neuroprotective Agents; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tumor Necrosis Factor-alpha | 2004 |
Nutritional iron deprivation attenuates kainate-induced neurotoxicity in rats: implications for involvement of iron in neurodegeneration.
Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Behavior, Animal; Blood Glucose; Blood Proteins; Body Weight; Brain; Brain Chemistry; Cell Count; Dietary Supplements; Disease Models, Animal; Hematocrit; Immunohistochemistry; Iron; Iron Deficiencies; Kainic Acid; Male; Membrane Glycoproteins; Microglia; Nerve Degeneration; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Silver Staining; Zinc | 2004 |
Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate.
Topics: Animals; Calcium; Cell Death; Cell Differentiation; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fructose; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Kainic Acid; Leukomalacia, Periventricular; Movement Disorders; Neuroprotective Agents; Oligodendroglia; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Topiramate; Treatment Outcome | 2004 |
Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Death; Cell Nucleus; Death-Associated Protein Kinases; Denervation; Disease Models, Animal; Functional Laterality; Hippocampus; Immunity, Innate; Kainic Acid; Male; Nerve Degeneration; Neurons; Nuclear Proteins; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Seizures; Tumor Suppressor Protein p53 | 2004 |
Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus.
Topics: Aging; Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Disease Models, Animal; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Mossy Fibers, Hippocampal; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Status Epilepticus; Up-Regulation | 2004 |
NBQX or topiramate treatment after perinatal hypoxia-induced seizures prevents later increases in seizure-induced neuronal injury.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Disease Models, Animal; DNA Fragmentation; Fructose; Hippocampus; Hypoxia, Brain; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Topiramate | 2004 |
Clinical and experimental studies of epilepsy associated with focal cortical dysplasia.
Topics: Animals; Animals, Newborn; Blood Vessels; Brain; Brain Neoplasms; Cerebrovascular Circulation; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Motor Cortex; Neoplasms, Neuroepithelial; Rats; Rats, Wistar; Somatosensory Cortex | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Antagonists; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapses | 2004 |
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; GAP-43 Protein; Growth Cones; Hyaluronan Receptors; Immunohistochemistry; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Nerve Degeneration; Neuronal Plasticity; Neuropeptide Y; Pilocarpine; Status Epilepticus; Up-Regulation | 2004 |
Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury.
Topics: Animals; Behavior, Animal; Benzofurans; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Gene Expression Regulation; Glutathione; Hippocampus; Interleukin-1; Kainic Acid; Lipid Peroxidation; Male; Malondialdehyde; Nerve Degeneration; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2004 |
Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration.
Topics: Animals; Apoptosis; Astrocytes; Cell Line, Transformed; Cell Survival; Chemokine CCL2; Chemokine CXCL2; Culture Media, Conditioned; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Fibroblast Growth Factor 2; Hippocampus; Kainic Acid; Macrophages; Male; Monokines; Nerve Degeneration; Nerve Regeneration; Neurodegenerative Diseases; Neurons; Neurotoxins; Rats; Rats, Inbred F344; Up-Regulation | 2004 |
Regulation of ion channel localization and phosphorylation by neuronal activity.
Topics: Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcimycin; Calcium Channel Blockers; Cell Count; Cells, Cultured; Cyclosporine; Delayed Rectifier Potassium Channels; Dendrites; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ion Channel Gating; Ionophores; Kainic Acid; Membrane Potentials; Neuronal Plasticity; Nitrendipine; Nitriles; Okadaic Acid; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyramidal Cells; Pyrethrins; Rats; Seizures; Shab Potassium Channels; Time Factors; Translocation, Genetic | 2004 |
Spatio-temporal changes in neurofilament proteins immunoreactivity following kainate-induced cerebellar lesion in rats.
Topics: Animals; Brain Injuries; Cerebellum; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Nerve Fibers, Myelinated; Nerve Regeneration; Neurofilament Proteins; Neuronal Plasticity; Neurons; Neurotoxins; Purkinje Cells; Rats; Rats, Wistar; Reaction Time; Synaptophysin; Up-Regulation | 2004 |
Hippocampal neurotransplantation evaluated in the rat kainic acid epilepsy model.
Topics: Animals; Cytotoxins; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Maze Learning; Neurons; Rats; Rats, Sprague-Dawley | 2004 |
Circadian rhythms in the retina of rats with photoreceptor degeneration.
Topics: Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Melatonin; Photoreceptor Cells, Vertebrate; Rats; Retina; Retinal Degeneration; RNA, Messenger | 2004 |
[Neurogenesis of dentate granule cells following kainic acid induced seizures in immature rats].
Topics: Animals; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Mossy Fibers, Hippocampal; Neurogenesis; Rats; Seizures | 2004 |
Neuropathology of seizures in the immature rabbit.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Fever; Hypotension; Kainic Acid; Muscarinic Agonists; Nerve Degeneration; Neurons; Pilocarpine; Prosencephalon; Rabbits; Seizures | 2004 |
[Neuronal damage in the hippocampus of inbred mouse strains in the models of epilepsy induced by kainic acid and pilocarpine].
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neurons; Pilocarpine; Species Specificity | 2004 |
Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat.
Topics: Animals; Disease Models, Animal; Electroencephalography; Electron Transport Complex I; Electron Transport Complex III; Electron Transport Complex IV; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mitochondria; Mitochondrial Diseases; Neurons; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2004 |
Aging alters electroencephalographic and clinical manifestations of kainate-induced status epilepticus.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred F344; Reaction Time; Status Epilepticus | 2004 |
Lipopolysaccharide-induced febrile convulsions in the rat: short-term sequelae.
Topics: Animals; Animals, Newborn; Body Temperature; Brain; Cell Death; Disease Models, Animal; Female; Fever; Humans; Immunohistochemistry; Kainic Acid; Lipopolysaccharides; Lithium; Pentylenetetrazole; Pilocarpine; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures, Febrile | 2004 |
Altered vulnerability to kainate excitotoxicity of transgenic-Cu/Zn SOD1 neurones.
Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Asparagine; Calcium Channel Blockers; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; Cobalt; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Transgenic; Motor Neurons; Neurotoxins; Nifedipine; Phosphopyruvate Hydratase; Sodium Channel Blockers; Spinal Cord; Superoxide Dismutase; Tetrodotoxin; Time Factors | 2004 |
Delayed onset of prepulse inhibition deficits following kainic acid treatment on postnatal day 7 in rats.
Topics: Acoustic Stimulation; Age Factors; Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Exploratory Behavior; Female; Hippocampus; Inhibition, Psychological; Kainic Acid; Limbic System; Male; Maze Learning; Motor Activity; Pregnancy; Rats; Rats, Long-Evans; Reaction Time; Reflex, Startle; Schizophrenia | 2004 |
Resistance of neurofilaments to degradation, and lack of neuronal death and mossy fiber sprouting after kainic acid-induced status epilepticus in the developing rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Hippocampus; Intermediate Filaments; Kainic Acid; Neurofilament Proteins; Neurons; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2004 |
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Differential Threshold; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Female; Hippocampus; Kainic Acid; Kindling, Neurologic; Nervous System Diseases; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures; Time Factors; Video Recording | 2004 |
Kinetics of glutamate and gamma-aminobutyric acid in cerebrospinal fluid in a canine model of complex partial status epilepticus induced by kainic acid.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dogs; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Kinetics; Microinjections; Status Epilepticus; Time Factors | 2004 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Fructose; Injections, Intraperitoneal; Kainic Acid; Pilocarpine; Rats; Rats, Sprague-Dawley; Research Design; Sodium Chloride; Status Epilepticus; Topiramate | 2005 |
Evidence for a role of the parafascicular nucleus of the thalamus in the control of epileptic seizures by the superior colliculus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agonists; Extracellular Fluid; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Microdialysis; Microinjections; Neural Pathways; Picrotoxin; Rats; Rats, Inbred Strains; Substantia Nigra; Superior Colliculi | 2005 |
Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Benzodiazepines; Cell Count; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; GABA Modulators; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Midazolam; Mossy Fibers, Hippocampal; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2005 |
Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches.
Topics: Animals; Antipyrine; Brain; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Laterality; Hippocampus; Indazoles; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Status Epilepticus | 2005 |
Up-regulation of peripherin is associated with alterations in synaptic plasticity in CA1 and CA3 regions of hippocampus.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Down-Regulation; Epilepsy; Fluorescent Antibody Technique; Gene Expression; Genetic Predisposition to Disease; Hippocampus; Intermediate Filament Proteins; Kainic Acid; Long-Term Potentiation; Membrane Glycoproteins; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neuronal Plasticity; Organ Culture Techniques; Peripherins; Promoter Regions, Genetic; Synaptic Transmission; Synaptophysin; Thalamus; Up-Regulation | 2005 |
Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Glutathione Disulfide; Glutathione Peroxidase; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2005 |
Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Epilepsy; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neuropeptide Y; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation | 2005 |
Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion.
Topics: Action Potentials; Animals; Behavior, Animal; Carbazoles; Cell Count; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Epilepsy; Hippocampus; Immunohistochemistry; Indole Alkaloids; Kainic Acid; Mice; Neurons; Neuropeptide Y; Perforant Pathway; Staining and Labeling; Time Factors | 2005 |
Effects of status epilepticus early in life on susceptibility to ischemic injury in adulthood.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Disease Susceptibility; Electroencephalography; Flurothyl; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Monitoring, Physiologic; Neocortex; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stroke | 2005 |
Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.
Topics: Animal Nutritional Physiological Phenomena; Animals; Apoptosis; Cell Death; Clusterin; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Glycoproteins; Hippocampus; Kainic Acid; Ketone Bodies; Ketosis; Male; Mice; Mice, Inbred ICR; Molecular Chaperones; Seizures | 2005 |
Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Quinolones; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Thiazoles | 2005 |
Postural changes after lesions of the substantia nigra pars reticulata in hemiparkinsonian monkeys.
Topics: Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Callithrix; Cell Count; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Female; Functional Laterality; Immunohistochemistry; Kainic Acid; Male; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Posture; Psychomotor Performance; Reaction Time; Substantia Nigra; Tyrosine 3-Monooxygenase | 2005 |
The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cells, Cultured; Cyclin G; Cyclin G1; Cyclins; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Gerbillinae; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Protein p53 | 2005 |
Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum.
Topics: Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Kainic Acid; Male; Neurotoxicity Syndromes; Oxidopamine; Phencyclidine; Rats; Rats, Sprague-Dawley; Reaction Time; Reinforcement Schedule | 2005 |
Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus.
Topics: Action Potentials; Animals; Brain Chemistry; Calbindins; Chronic Disease; Disease Models, Animal; Down-Regulation; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Galanin; Hippocampus; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Nerve Degeneration; Neural Pathways; Neuropeptide Y; Neurotoxins; Pyramidal Cells; S100 Calcium Binding Protein G; Sincalide; Status Epilepticus; Theta Rhythm; Up-Regulation | 2005 |
Clinical application of experimental cortical dysplasia in rats.
Topics: Adolescent; Animals; Animals, Newborn; Cerebral Cortex; Child; Child, Preschool; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Female; Humans; Infant; Kainic Acid; Male; Rats; Rats, Wistar; Retrospective Studies | 2005 |
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Topics: Adenosine Kinase; Animals; Astrocytes; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Locomotion; Male; Mice; Mice, Transgenic; Neurons; Transgenes; Tubercidin; Up-Regulation | 2005 |
Short-term effects of kainic acid on CA1 hippocampal interneurons differentially vulnerable to excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; In Vitro Techniques; Interneurons; Kainic Acid; Male; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Somatostatin; Tetrodotoxin | 2005 |
ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.
Topics: ADAM Proteins; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Convulsants; Dentate Gyrus; Disease Models, Animal; Disintegrins; Endopeptidases; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Membrane Proteins; Metalloendopeptidases; Metalloproteases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Status Epilepticus; Up-Regulation | 2005 |
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors.
Topics: Animals; Cells, Cultured; Convulsants; Cyclohexanes; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurons; Neuropeptide Y; Organ Culture Techniques; Receptors, Neuropeptide Y; Synaptic Transmission; Xanthenes | 2005 |
Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Hippocampus; Kainic Acid; Male; Neurons; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley | 2005 |
Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus.
Topics: Animals; Calcium; Cell Death; Chromatography, High Pressure Liquid; Disease Models, Animal; DNA, Single-Stranded; Dose-Response Relationship, Drug; Electrochemistry; Extracellular Space; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Mice; Neurons; Neurotransmitter Agents; Potassium; Proto-Oncogene Proteins c-fos; Ruthenium Red; Ryanodine; Ryanodine Receptor Calcium Release Channel; Status Epilepticus; Time Factors | 2005 |
Differential GABA(A) subunit expression following status epilepticus in seizure-prone and seizure-resistant rats: a putative mechanism for refractory drug response.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Agonists; Gene Expression; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Peptide Fragments; Polymerase Chain Reaction; Rats; Rats, Long-Evans; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Seizures; Species Specificity; Status Epilepticus; Transcription, Genetic | 2005 |
Physiological changes in chronic epileptic rats are prominent in superficial layers of the medial entorhinal area.
Topics: Animals; Cell Count; Cell Death; Chronic Disease; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley | 2005 |
Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Kainic Acid; Male; Models, Neurological; Mossy Fibers, Hippocampal; Neural Pathways; Patch-Clamp Techniques; Photolysis; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Status Epilepticus; Synaptic Transmission | 2005 |
Inflammatory response and glia activation in developing rat hippocampus after status epilepticus.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Western; Cytokines; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-6; Kainic Acid; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Status Epilepticus; Tumor Necrosis Factor-alpha | 2005 |
Behavioral and histopathological analysis of domoic Acid administration in marmosets.
Topics: Animals; Behavior, Animal; Brain; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Female; Follow-Up Studies; Injections, Intraperitoneal; Kainic Acid; Male; Motor Activity; Neurotoxicity Syndromes; Status Epilepticus | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Iodine Radioisotopes; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Neocortex; Rats; Receptors, GABA-A; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon | 2005 |
Proechimys guyannensis: an animal model of resistance to epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Immunity, Innate; Kainic Acid; Kindling, Neurologic; Male; Pilocarpine; Rats; Rats, Wistar; Rodentia; Species Specificity; Status Epilepticus | 2005 |
Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Atrophy; Basal Nucleus of Meynert; Brain Damage, Chronic; Cholinergic Agents; Convulsants; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Female; Immunotoxins; Injections, Intraventricular; Kainic Acid; Male; N-Glycosyl Hydrolases; Nerve Degeneration; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Ribosome Inactivating Proteins, Type 1; Saporins | 2005 |
Simultaneous glutamate and GABA(A) receptor agonist administration increases calbindin levels and prevents hippocampal damage induced by either agent alone in a model of perinatal brain injury.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain Injuries; Calbindins; Cells, Cultured; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; GABA Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Muscimol; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; S100 Calcium Binding Protein G | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Epilepsy, Temporal Lobe; Kainic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Substance Withdrawal Syndrome | 2005 |
Pentoxifylline and insulin-like growth factor-I (IGF-I) abrogate kainic acid-induced cognitive impairment in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fluoresceins; Free Radical Scavengers; Hippocampus; Insulin-Like Growth Factor Binding Protein 1; Kainic Acid; Male; Mice; Mice, Inbred ICR; Motor Activity; Nerve Degeneration; Neurons; Organic Chemicals; Pentoxifylline | 2005 |
Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neuronal Plasticity; Pyramidal Cells; Rats; Rats, Inbred F344; Transplantation, Homologous | 2005 |
Time course changes of estrogen receptor alpha expression in the adult rat hippocampus after kainic acid-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Estrogen Receptor alpha; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Status Epilepticus; Time Factors | 2005 |
Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Calbindin 2; Cell Count; Cell Division; Cell Movement; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Intermediate Filament Proteins; Kainic Acid; Ki-67 Antigen; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Models, Biological; Nerve Tissue Proteins; Nestin; Neuropeptides; Phosphopyruvate Hydratase; S100 Calcium Binding Protein G; Seizures; Stem Cells; Time Factors | 2005 |
Increase in hippocampal cell death after treatment with kainate in zinc deficiency.
Topics: Animals; Cell Death; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Extracellular Fluid; Food, Formulated; Hippocampus; In Situ Nick-End Labeling; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Up-Regulation; Zinc | 2005 |
Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cell Survival; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Male; Mice; Neurons; Phosphopyruvate Hydratase; Seizures; Time Factors | 2005 |
In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures.
Topics: Animals; Behavior, Animal; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Count; Cell Death; Chlorocebus aethiops; COS Cells; Disease Models, Animal; Docosahexaenoic Acids; Enzyme Activation; Excitatory Amino Acid Agonists; Functional Laterality; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Seizures; Transduction, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Studies of damage to hippocampal neurons in inbred mouse lines in models of epilepsy using kainic acid and pilocarpine.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; HSP70 Heat-Shock Proteins; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurons; Pilocarpine; Species Specificity | 2005 |
Cell type-specific changes in spontaneous and minimally evoked excitatory synaptic activity in hippocampal CA1 interneurons of kainate-treated rats.
Topics: Animals; Convulsants; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hippocampus; Interneurons; Kainic Acid; Kindling, Neurologic; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2006 |
Protective effects of betaxolol in eyes with kainic acid-induced neuronal death.
Topics: Analysis of Variance; Animals; Betaxolol; Cell Count; Cell Death; Choline O-Acetyltransferase; Disease Models, Animal; Drug Administration Routes; Drug Administration Schedule; Immunohistochemistry; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Febrile convulsions induced by the combination of lipopolysaccharide and low-dose kainic acid enhance seizure susceptibility, not epileptogenesis, in rats.
Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Body Temperature; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Lipopolysaccharides; Male; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile | 2005 |
Seizure-induced changes in mitochondrial redox status.
Topics: Animals; Coenzyme A; Cysteine; Disease Models, Animal; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Hippocampus; Kainic Acid; Male; Mitochondria; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Time Factors | 2006 |
Chronic bilateral stimulation of the anterior thalamus of kainate-treated rats increases seizure frequency.
Topics: Acute Disease; Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Disease Models, Animal; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Functional Laterality; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Status Epilepticus; Videotape Recording | 2006 |
Environmental enrichment reverses the impaired exploratory behavior and altered gene expression induced by early-life seizures.
Topics: Animals; Disease Models, Animal; Environment; Epilepsy; Excitatory Amino Acid Agonists; Exploratory Behavior; Gene Expression Regulation, Developmental; Kainic Acid; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2005 |
Activation of Rho after traumatic brain injury and seizure in rats.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Diazepam; Disease Models, Animal; Drug Interactions; Enzyme Activation; Gene Expression Regulation, Enzymologic; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Seizures | 2006 |
Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspases; Cytochromes c; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Minocycline; Neuroprotective Agents | 2006 |
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Fluoresceins; Forelimb; Functional Laterality; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neuropeptide Y; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344; Seizures; Silver Staining; Time Factors | 2006 |
Repeatable focal seizure suppression: a rat preparation to study consequences of seizure activity based on urethane anesthesia and reversible carotid artery occlusion.
Topics: Anesthetics, Intravenous; Animals; Arterial Occlusive Diseases; Blood Pressure; Carotid Artery Diseases; Disease Models, Animal; Electroencephalography; Electromyography; Functional Laterality; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Urethane | 2006 |
Neuroprotective effects of olanzapine in a rat model of neurodevelopmental injury.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Disease Models, Animal; Female; Injections, Intraventricular; Kainic Acid; Neuroprotective Agents; Olanzapine; Rats; Rats, Sprague-Dawley | 2006 |
Region-specific reduction in entorhinal gamma oscillations and parvalbumin-immunoreactive neurons in animal models of psychiatric illness.
Topics: Animals; Disease Models, Animal; Entorhinal Cortex; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Ketamine; Male; Mental Disorders; Mice; Mice, Knockout; Neural Inhibition; Neurons; Oscillometry; Parvalbumins; TNF Receptor-Associated Factor 3 | 2006 |
The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy.
Topics: Action Potentials; Animals; Behavior, Animal; Brain; Cerebral Cortex; Convulsants; Cost-Benefit Analysis; Disease Models, Animal; Electroencephalography; Electronics, Medical; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Microelectrodes; Neurons; Neurophysiology; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Status Epilepticus; Telemetry; Time Factors | 2006 |
Alterations of taurine in the brain of chronic kainic acid epilepsy model.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures; Taurine | 2006 |
[Effect of ketogenic diet on hippocampus synaptic reorganization and GluR5 expression in kainic acid induced rat model of epilepsy].
Topics: Animals; Blotting, Western; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Chromosome Pairing; Dentate Gyrus; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Pyramidal Cells; Rats; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Impairment of dentate gyrus neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Differentiation; Disease Models, Animal; Doublecortin Domain Proteins; Epilepsy, Temporal Lobe; Functional Laterality; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Microtubule-Associated Proteins; Neurons; Neuropeptides; Proliferating Cell Nuclear Antigen; Stem Cells; Time Factors | 2006 |
A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo.
Topics: Animals; Brain; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Convulsants; Disease Models, Animal; Enzyme Activation; Epilepsy; Kainic Acid; Male; Membrane Potentials; Neurons; Phosphorylation; Rats; Rats, Wistar; Recovery of Function; Solubility; Status Epilepticus; Threonine | 2006 |
P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain.
Topics: Animals; Astrocytes; Biomarkers; Brain; Calcium-Binding Proteins; Convulsants; Cyclooxygenase 1; Disease Models, Animal; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Male; Membrane Proteins; Microfilament Proteins; Microglia; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2006 |
Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures.
Topics: Animals; Biomarkers; Convulsants; Cyclooxygenase 2; Disease Models, Animal; Encephalitis; Epilepsy; Gliosis; Glutamic Acid; Immunohistochemistry; Kainic Acid; Limbic System; Male; Microglia; Olfactory Pathways; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Up-Regulation | 2006 |
Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Conditioning, Classical; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy; Epilepsy, Temporal Lobe; Fear; Freezing Reaction, Cataleptic; Kainic Acid; Male; Motor Activity; Rats; Rats, Wistar; Status Epilepticus; Videotape Recording | 2006 |
Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation.
Topics: Animals; Benzodiazepines; Cell Death; Chelating Agents; Disease Models, Animal; Ditiocarb; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Hippocampus; HSP72 Heat-Shock Proteins; Kainic Acid; Male; Mice; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Zinc | 2006 |
Adenosine A1 receptors are crucial in keeping an epileptic focus localized.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy; Female; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A1; Status Epilepticus | 2006 |
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Immunohistochemistry; In Situ Hybridization; Isoenzymes; Kainic Acid; Neurons; Olfactory Pathways; Pilocarpine; Protein Isoforms; Rats; Rats, Wistar; RNA, Messenger; Status Epilepticus | 2006 |
Behavioral and hippocampal changes after prenatal invasive interventions with possible relevance to schizophrenia.
Topics: Age Factors; Analysis of Variance; Animals; Cell Size; Discrimination Learning; Disease Models, Animal; Exploratory Behavior; Female; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Reaction Time; Risk Factors; Schizophrenia; Social Behavior | 2006 |
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.
Topics: Animals; Anticonvulsants; Azepines; Brain; Caspase 1; Caspase Inhibitors; Disease Models, Animal; Hippocampus; Interleukin-1; Isoquinolines; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prodrugs; Protease Inhibitors; Pyridazines; Rats; Seizures; Tissue Culture Techniques | 2006 |
The combined use of non-radioactive in situ hybridization and real-time RT-PCR to assess gene expression in cryosections.
Topics: Animals; Cell Communication; Cell Count; Connexin 43; Convulsants; Disease Models, Animal; Epilepsy; Gap Junctions; Gene Expression; Hippocampus; Image Cytometry; In Situ Hybridization; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Gender-based changes in cognition and emotionality in a new rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Emotions; Epilepsy; Female; Hippocampus; Kainic Acid; Male; Maze Learning; Neuromuscular Depolarizing Agents; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2007 |
Synaptic reorganization in subiculum and CA3 after early-life status epilepticus in the kainic acid rat model.
Topics: Animals; Disease Models, Animal; Female; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Mossy Fibers, Hippocampal; Neuronal Plasticity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Selenite; Status Epilepticus; Synapses | 2007 |
Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice.
Topics: Animals; Astrocytes; Brain Injuries; Cell Communication; Cell Survival; Cytoprotection; Disease Models, Animal; Drug Resistance; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Recovery of Function; Seizures; Up-Regulation | 2006 |
Effect of ketogenic diet on hippocampus mossy fiber sprouting and GluR5 expression in kainic acid induced rat model.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Ketone Bodies; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA, Messenger | 2006 |
Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains.
Topics: Animals; Chimera; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Genetic Predisposition to Disease; Huntington Disease; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred ICR; Nerve Degeneration; Neurons; Neurotoxins; Phenotype; Quinolinic Acid; Species Specificity | 2006 |
Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis.
Topics: Acute Disease; Animals; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Inhibitory Postsynaptic Potentials; Kainic Acid; Mice; Mice, Inbred C57BL; Neural Inhibition; Organ Culture Techniques; Ouabain; Psychoses, Substance-Induced; Pyramidal Cells; Schizophrenia; Sodium-Potassium-Exchanging ATPase | 2007 |
A pathogenetic hypothesis of Unverricht-Lundborg disease onset and progression.
Topics: Animals; Cystatin B; Cystatins; Disease Models, Animal; Disease Progression; Electrophysiology; Epilepsies, Myoclonic; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Nerve Degeneration; Neurons; Organ Culture Techniques; Unverricht-Lundborg Syndrome | 2007 |
Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Functional Laterality; Injections, Intraventricular; Kainic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Receptors, Glutamate; Videotape Recording | 2007 |
Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10.
Topics: Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Erythropoietin; Excitatory Amino Acid Agonists; Hippocampus; Humans; Hypoxia; Hypoxia, Brain; Kainic Acid; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Hippocampus; Kainic Acid; Male; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus; Tetrahydroisoquinolines; Video Recording | 2007 |
Mechanisms of the blockade of glutamate channel receptors: significance for structural and physiological investigations.
Topics: Animals; Animals, Newborn; Arecoline; Diamines; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Ion Channel Gating; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, Glutamate; Tremor | 2007 |
The effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal cortical seizure status in rats.
Topics: Animals; Anterior Thalamic Nuclei; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; Electrodes, Implanted; Electroencephalography; Epilepsies, Partial; Functional Laterality; Glucose; Kainic Acid; Male; Rats; Rats, Wistar; Status Epilepticus; Stereotaxic Techniques; Tissue Distribution | 2007 |
Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance.
Topics: Alexander Disease; Animals; Astrocytes; Central Nervous System; Disease Models, Animal; Drug Resistance; Glial Fibrillary Acidic Protein; Humans; Inclusion Bodies; Intermediate Filament Proteins; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Nervous System Malformations; Nestin; Promoter Regions, Genetic; Survival Rate; Transgenes | 2007 |
Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Interneurons; Isoenzymes; Kainic Acid; Male; Neural Inhibition; Neural Pathways; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2007 |
Status epilepticus alters zolpidem sensitivity of [3H]flunitrazepam binding in the developing rat brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; GABA Agonists; GABA Modulators; Kainic Acid; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Zolpidem | 2007 |
Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex.
Topics: Animals; Cerebral Cortex; Dendritic Spines; Disease Models, Animal; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptor, trkB; Silver Staining; Statistics, Nonparametric; Status Epilepticus; Time Factors | 2007 |
BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.
Topics: Animals; Apoptosis; Botulinum Toxins; Caspase 3; Disease Models, Animal; Drug Interactions; Enzyme Activation; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kainic Acid; Lithium Compounds; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Sclerosis; Wnt Proteins | 2007 |
A quantitative trait locus on chromosome 18 is a critical determinant of excitotoxic cell death susceptibility.
Topics: Animals; Brain; Cell Death; Chromosomes, Mammalian; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Humans; Kainic Acid; Male; Mice; Mice, Congenic; Neurons; Phenotype; Quantitative Trait Loci; Seizures | 2007 |
BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.
Topics: Animals; Apoptosis; Botulinum Toxins; Caspase 3; Disease Models, Animal; Drug Interactions; Enzyme Activation; Hippocampus; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Flumazenil; Injections, Intraperitoneal; Kainic Acid; Midazolam; Rats; Receptors, GABA-A; Status Epilepticus; Treatment Outcome; Tritium | 2007 |
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Convulsants; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Hippocampus; Humans; Kainic Acid; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Phosphorylation; Seizures; tau Proteins | 2007 |
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.
Topics: Age Factors; Amino Acid Transport System X-AG; Animals; Astrocytes; Blotting, Western; Clusterin; Complement Factor H; Cytokines; Disease Models, Animal; Disease Susceptibility; Fluorescent Antibody Technique; Hippocampus; Immunohistochemistry; Inflammation; Kainic Acid; Male; Microglia; Neuroglia; Random Allocation; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Up-Regulation | 2007 |
Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy.
Topics: Animals; Calbindins; Cell Count; Disease Models, Animal; Embryo, Mammalian; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Inbred F344; S100 Calcium Binding Protein G | 2007 |
Effect of oxcarbazepine pretreatment on convulsive activity and brain damage induced by kainic acid administration in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Oxcarbazepine; Rats; Rats, Wistar | 2008 |
Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.
Topics: Administration, Oral; Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Epilepsy; Food, Fortified; Injections, Intraperitoneal; Kainic Acid; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Neuroprotective effects of resident microglia following acute brain injury.
Topics: Animals; Bone Marrow Transplantation; Brain Injuries; Disease Models, Animal; Glucocorticoids; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myeloid Differentiation Factor 88; NF-kappa B; Nitroprusside; Stilbamidines; Thymidine Kinase; Time Factors | 2007 |
Multiparametric MRI evaluation of kainic acid-induced neuronal activation in rat hippocampus.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Mapping; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gadolinium DTPA; Hippocampus; Kainic Acid; Magnesium; Magnetic Resonance Imaging; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
Protective effect of topiramate on kainic acid-induced cell death in mice hippocampus.
Topics: Animals; Apoptosis; Benzoxazines; Blotting, Western; Caspase 3; Cell Death; Cell Survival; Disease Models, Animal; Fructose; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraventricular; Kainic Acid; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Oxazines; Seizures; Topiramate | 2008 |
IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Hippocampus; Insulin-Like Growth Factor II; Kainic Acid; Limbic System; Mice; Mice, Knockout; Nerve Degeneration; Neural Pathways; Neurotoxins; Organ Culture Techniques | 2007 |
Synaptic localization of seizure-induced matrix metalloproteinase-9 mRNA.
Topics: Animals; Dendrites; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Immunoelectron; Oncogene Proteins v-fos; Rats; Rats, Wistar; RNA, Messenger; S100 Proteins; Status Epilepticus; Synapses; Synaptosomes; Time Factors | 2007 |
Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning.
Topics: Animals; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Gene Expression Profiling; Hippocampus; Ischemic Preconditioning; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Status Epilepticus; Treatment Outcome; Up-Regulation | 2007 |
Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats.
Topics: 4-Aminopyridine; Animals; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Entorhinal Cortex; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2008 |
Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus.
Topics: Analysis of Variance; Animals; CD11b Antigen; Chemokine CCL2; Disease Models, Animal; Evans Blue; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2007 |
Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice | 2007 |
In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats.
Topics: Animals; Antineoplastic Agents; Autoradiography; Binding, Competitive; Brain; Carbon Radioisotopes; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Isoquinolines; Kainic Acid; Ligands; Male; Neurotoxins; Positron-Emission Tomography; Purines; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A | 2007 |
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Situ Nick-End Labeling; In Vitro Techniques; Ion Channels; Kainic Acid; Potassium Channels; Rats; Rats, Sprague-Dawley; Seizures | 2008 |
Altered pre-pulse inhibition in adult rats treated neonatally with domoic acid.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; Glutamic Acid; Humans; Kainic Acid; Male; Neuromuscular Depolarizing Agents; Rats; Reflex, Acoustic; Reflex, Startle; Schizophrenia; Sex Factors; Time Factors | 2008 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Fructosediphosphates; Kainic Acid; Male; Meperidine; Models, Chemical; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2007 |
nNOS-dependent reactivity of cerebral arterioles in Type 1 diabetes.
Topics: Animals; Cerebral Arteries; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxides | 2007 |
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
Topics: Animals; Astrocytes; Cathepsins; Coloring Agents; Disease Models, Animal; Enzyme Activation; Epilepsy; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Kainic Acid; Lysosomes; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurotoxins; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Pyramidal Cells; Up-Regulation | 2007 |
Time-dependent changes in distribution of basic fibroblast growth factor immunoreactive cells in rat hippocampus after status epilepticus.
Topics: Animals; Astrocytes; Behavior, Animal; Cell Count; Cell Size; Disease Models, Animal; Electroencephalography; Fibroblast Growth Factor 2; Hippocampus; Kainic Acid; Pyramidal Cells; Rats; Rats, Wistar; Reaction Time; Status Epilepticus; Time Factors | 2007 |
Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus.
Topics: Animals; Calpain; Caspases; Convulsants; Dipeptides; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Epilepsy; Fluoresceins; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Organic Chemicals; Rats; Rats, Wistar; Spectrin; Status Epilepticus; Time Factors | 2008 |
Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Anti-Dyskinesia Agents; Botulinum Toxins; Cell Count; Disease Models, Animal; Drug Interactions; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Neuropeptide Y; Reelin Protein; Synaptosomal-Associated Protein 25 | 2008 |
Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors.
Topics: Analysis of Variance; Animals; Cell Survival; Cyclooxygenase Inhibitors; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Kainic Acid; Male; Mice; Mice, Inbred ICR; Receptors, Prostaglandin; Seizures | 2008 |
Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo.
Topics: Animals; Apoptosis; bcl-X Protein; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Gene Products, tat; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 2008 |
Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice.
Topics: Aging, Premature; Animals; Caspase 3; Cytochromes c; Disease Models, Animal; Enzyme Activation; Glutathione; Glutathione Disulfide; Hippocampus; Ion Channels; Kainic Acid; Lipid Peroxidation; Lipofuscin; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria; Mitochondrial Proteins; Nerve Degeneration; Neurons; Oxidation-Reduction; Oxidative Stress; Proteins; Proto-Oncogene Proteins c-fos; Seizures; Superoxide Dismutase; Time Factors; Uncoupling Protein 2 | 2008 |
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
Topics: Animals; Carrier Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Entorhinal Cortex; Evoked Potentials; GABA Agonists; GABA Plasma Membrane Transport Proteins; In Vitro Techniques; Isoxazoles; Kainic Acid; Male; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Status Epilepticus; Tiagabine | 2008 |
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Indoles; Kainic Acid; Leucine; Membrane Proteins; Mice; Mice, Transgenic; Mutation; Neurons; Plant Lectins; Seizures; Stress, Physiological; Valine | 2008 |
Mitochondrial DNA damage and impaired base excision repair during epileptogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitum; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Deoxyglucose; Deoxyguanosine; Disease Models, Animal; DNA Glycosylases; DNA Repair; DNA, Mitochondrial; Epilepsy, Temporal Lobe; Fumarate Hydratase; Gene Expression Regulation; Hydrogen Peroxide; Kainic Acid; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.
Topics: Animals; Cell Death; Ceramides; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Humans; In Situ Nick-End Labeling; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2008 |
Inflammation modifies status epilepticus-induced hippocampal injury during development.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Hippocampus; Inflammation; Kainic Acid; Lipopolysaccharides; Lithium Chloride; Neurons; Pilocarpine; Rats; Status Epilepticus | 2007 |
The role of mitochondria in status epilepticus.
Topics: Animals; Caspases; Cats; Cell Death; Disease Models, Animal; Free Radicals; Hippocampus; Humans; Kainic Acid; Mitochondria; Mitochondrial Diseases; Neurons; Oxidative Stress; Rats; Status Epilepticus | 2007 |
Effective treatments of prolonged status epilepticus in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Kainic Acid; Male; Pentobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors | 2008 |
Loss of astrocytic domain organization in the epileptic brain.
Topics: Amino Acids; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Behavior, Animal; Brain; Dendrites; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Kainic Acid; Luminescent Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Time Factors; Valproic Acid | 2008 |
Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 2; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Hippocampus; Kainic Acid; Male; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Membrane Proteins; Mice; Mice, Knockout; Mutation; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Reaction Time; Receptors, Somatostatin; Seizures | 2008 |
Granule cell dispersion develops without neurogenesis and does not fully depend on astroglial cell generation in a mouse model of temporal lobe epilepsy.
Topics: Age Factors; Analysis of Variance; Animals; Astrocytes; Bromodeoxyuridine; Cell Count; Cell Death; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphopyruvate Hydratase; Radiation; Statistics, Nonparametric; Time Factors | 2008 |
Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats.
Topics: Amygdala; Analysis of Variance; Animals; Cell Death; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Down-Regulation; Electroencephalography; Electroshock; Entorhinal Cortex; Female; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Kainic Acid; Kindling, Neurologic; Phosphopyruvate Hydratase; Potassium Channels; Rats; Rats, Wistar; RNA, Messenger; Status Epilepticus; Time Factors | 2008 |
Edaravone prevents kainic acid-induced neuronal death.
Topics: Aldehydes; Animals; Antipyrine; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Edaravone; Epilepsy; Free Radical Scavengers; Glutathione; Kainic Acid; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Status Epilepticus; Treatment Outcome | 2008 |
Chemoconvulsant model of chronic spontaneous seizures.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroshock; Excitatory Amino Acid Agonists; Kainic Acid; Male; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2005 |
Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice.
Topics: Amygdala; Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Functional Laterality; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microinjections; Nerve Tissue Proteins; Reaction Time; Statistics, Nonparametric; Time Factors | 2008 |
A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamates; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Fructose; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Topiramate; Video Recording | 2008 |
GABA and benzodiazepine receptors in basal ganglia function.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Huntington Disease; Kainic Acid; Neural Inhibition; Neural Pathways; Putamen; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Opioid; Substantia Nigra; Synaptic Transmission | 1984 |
Experimental central neurogenic hypertension from brainstem dysfunction: evidence for a central neural imbalance hypothesis of hypertension.
Topics: Animals; Autonomic Fibers, Preganglionic; Blood Pressure; Blood Vessels; Brain Stem; Carotid Sinus; Cats; Disease Models, Animal; Dogs; Electric Stimulation; Glutamates; Heart Rate; Hypertension; Kainic Acid; Neurons, Afferent; Neurotransmitter Agents; Pressoreceptors; Rats; Synaptic Transmission | 1981 |
Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Male; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Recurrence; Seizures; Species Specificity; Time Factors | 1982 |
Limbic status epilepticus: behaviour and sleep alterations after intra-amygdaloid kainic acid microinjections in Papio Papio baboons.
Topics: Aggression; Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Humans; Kainic Acid; Limbic System; Microinjections; Papio; Sleep Stages; Sleep Wake Disorders; Status Epilepticus; Wakefulness | 1982 |
Reversal of long-term locomotor abnormalities in the kainic acid model of Huntington's disease by day 18 fetal striatal implants.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Female; Fetus; Huntington Disease; Kainic Acid; Locomotion; Pregnancy; Rats; Rats, Inbred Strains | 1983 |
L-pyroglutamate: an alternate neurotoxin for a rodent model of Huntington's disease.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Corpus Striatum; Disease Models, Animal; Huntington Disease; Kainic Acid; Male; Mice; Microscopy, Electron; Pyrrolidinones; Pyrrolidonecarboxylic Acid | 1984 |
[Activity of dopaminergic neurons of the substantia nigra following lesions of the neostriatum by kainic acid].
Topics: Action Potentials; Animals; Caudate Nucleus; Disease Models, Animal; Dopamine; Electrophysiology; Huntington Disease; Kainic Acid; Male; Neurons; Putamen; Pyrrolidines; Rats; Rats, Inbred Strains; Substantia Nigra | 1984 |
Enhanced behavioral response to nicotine in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Dextroamphetamine; Disease Models, Animal; Humans; Kainic Acid; Male; Motor Activity; Nicotine; Rats | 1983 |
Status epilepticus and brain maturation.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Female; Kainic Acid; Limbic System; Male; Pentylenetetrazole; Pyrrolidines; Rats; Status Epilepticus | 1984 |
Anterograde and transsynaptic degeneration 'en cascade' in basal ganglia induced by intrastriatal injection of kainic acid: an animal analogue of Huntington's disease.
Topics: Acetylcholinesterase; Animals; Basal Ganglia; Corpus Striatum; Disease Models, Animal; Female; Globus Pallidus; Huntington Disease; Kainic Acid; Male; Nerve Degeneration; Neurons; Pyrrolidines; Rats; Substantia Nigra; Synapses | 1980 |
Metabolic alterations in an animal model of Huntington's disease using the 14C-deoxyglucose method.
Topics: Animals; Autoradiography; Deoxy Sugars; Deoxyglucose; Disease Models, Animal; Huntington Disease; Kainic Acid; Male; Rats | 1980 |
Striatal ganglioside levels in the rat following kainic acid lesions: comparison with Huntington's disease.
Topics: Animals; Brain Chemistry; Corpus Striatum; Disease Models, Animal; Gangliosides; Humans; Huntington Disease; Kainic Acid; Male; Pyrrolidines; Rats; Tissue Distribution | 1981 |
Infantile status epilepticus and future seizure susceptibility in the rat.
Topics: Age Factors; Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Kainic Acid; Limbic System; Male; Rats; Rats, Inbred Strains; Recurrence; Status Epilepticus | 1984 |
Usefulness of parenteral kainic acid as a model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Brain Damage, Chronic; Disease Models, Animal; Epilepsy, Temporal Lobe; Glucose; Hippocampus; Kainic Acid; Pyrrolidines; Rats; Syndrome | 1984 |
Kainic-acid-induced seizures: a developmental study.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1984 |
[A new model of epilepsy--a small epileptic focus by microinjection of kainic acid into the unilateral hippocampus in cats (author's transl)].
Topics: Animals; Cats; Disease Models, Animal; Electroencephalography; Hippocampus; Kainic Acid; Microinjections; Pyrrolidines; Seizures | 1981 |
Intrastriatal kainic acid- a possible model for antidyskinetic/antichoreic agents?
Topics: Animals; Behavior, Animal; Chorea; Corpus Striatum; Disease Models, Animal; Guinea Pigs; Injections; Kainic Acid; Movement Disorders; Pyrrolidines | 1980 |
Spontaneously recurrent seizures after intracerebral injections of kainic acid in rat: a possible model of human temporal lobe epilepsy.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Male; Pyrrolidines; Rats; Seizures; Stereotyped Behavior; Temporal Lobe | 1980 |
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Kainic Acid; Nerve Degeneration; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Plasticity of AMPA and NMDA receptor-mediated epileptiform activity in a chronic model of temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetany | 1995 |
Seizure susceptibility in immature rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate.
Topics: Age Factors; Animals; Bicuculline; Body Weight; Brain; Disease Models, Animal; Female; Humans; Infant, Newborn; Kainic Acid; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Wistar; Seizures | 1995 |
Effect of inhibiting NO synthesis on hippocampal extracellular glutamate concentration in seizures induced by kainic acid.
Topics: Animals; Arginine; Blood Glucose; Disease Models, Animal; Electrophysiology; Glutamic Acid; Hippocampus; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Seizures; Time Factors | 1995 |
Differential susceptibility to seizures induced by systemic kainic acid treatment in mature DBA/2J and C57BL/6J mice.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Seizures; Species Specificity | 1995 |
Delayed cell death in the contralateral hippocampus following kainate injection into the CA3 subfield.
Topics: Animals; Calbindin 2; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Pyramidal Cells; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Silver Staining; Time Factors | 1995 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Kainic Acid; Male; Mice; Pentylenetetrazole; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1993 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Fentanyl; Kainic Acid; Meperidine; Mice; Mice, Inbred Strains; Morphine; N-Methylaspartate; Propofol; Seizures | 1995 |
Early and transient increase of rat hippocampal blood-brain barrier permeability to amino acids during kainic acid-induced seizures.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Disease Models, Animal; Hippocampus; Kainic Acid; Male; Permeability; Rats; Rats, Wistar; Seizures | 1995 |
Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.
Topics: Animals; Blotting, Western; Disease Models, Animal; Epilepsy; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Stress, Physiological; Temporal Lobe | 1995 |
[Jacksonian seizure model induced by a kainic acid microinjection into unilateral sensori-motor cortex].
Topics: Animals; Cats; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Glucose; Kainic Acid; Microinjections; Motor Cortex; Rats; Rats, Wistar | 1995 |
The activity of opioid analgesics in seizure models utilizing N-methyl-DL-aspartic acid, kainic acid, bicuculline and pentylenetetrazole.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Bicuculline; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Mice; N-Methylaspartate; Naloxone; Pentylenetetrazole; Seizures | 1994 |
[Electrophysiological and behavioral features of septal seizures in cats--experimental sham-rage seizures induced by injection of kainic acid].
Topics: Animals; Behavior, Animal; Brain; Cats; Disease Models, Animal; Electroencephalography; Humans; Kainic Acid; Monitoring, Physiologic; Seizures | 1994 |
Roles of dopamine and its receptors in generation of choreic movements.
Topics: Afferent Pathways; Animals; Brain Mapping; Cerebral Cortex; Choline O-Acetyltransferase; Chorea; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Levodopa; Macaca; Neurons; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Substantia Nigra; Synapses; Tyrosine 3-Monooxygenase | 1993 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; Dominance, Cerebral; Dose-Response Relationship, Drug; Drug Combinations; Epilepsy, Temporal Lobe; Ether; Hippocampus; Injections; Injections, Intraperitoneal; Kainic Acid; Magnesium Sulfate; Male; Necrosis; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Neurons; Pentobarbital; Pyramidal Cells; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Seizures | 1993 |
Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: an animal model of schizophrenia.
Topics: Animals; Brain Mapping; Caudate Nucleus; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Motor Activity; Nerve Degeneration; Neural Pathways; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Schizophrenia; Spiperone; Temporal Lobe; Up-Regulation | 1995 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Histocytochemistry; Imidazoles; Kainic Acid; Male; Medetomidine; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Seizures; Status Epilepticus; Vigabatrin | 1995 |
Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Time Factors | 1996 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; Central Nervous System; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Ethanol; Excitatory Amino Acid Agonists; Kainic Acid; Male; Medicine, African Traditional; Mice; Pentylenetetrazole; Plant Extracts; Plant Leaves; Plants, Medicinal; Poisoning; Rats; Rats, Wistar; Seizures | 1996 |
Postictal alteration of sodium content and apparent diffusion coefficient in epileptic rat brain induced by kainic acid.
Topics: Amygdala; Animals; Brain; Brain Chemistry; Disease Models, Animal; Epilepsy, Temporal Lobe; Extracellular Space; Hippocampus; Humans; Intracellular Fluid; Kainic Acid; Magnetic Resonance Imaging; Olfactory Pathways; Putamen; Rats; Rats, Sprague-Dawley; Sodium; Sodium Isotopes | 1996 |
Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain.
Topics: Animals; Brain Chemistry; Calpain; Disease Models, Animal; Enzyme Activation; Epilepsy, Temporal Lobe; Humans; Immunohistochemistry; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Spectrin | 1996 |
A role for synaptic and network plasticity in controlling epileptiform activity in CA1 in the kainic acid-lesioned rat hippocampus in vitro.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
NG-nitro-L-arginine differentially affects glutamate- or kainate-induced seizures.
Topics: Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nitroarginine; Seizures | 1996 |
Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats.
Topics: Age Factors; Animals; Cell Count; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Kainic Acid; Male; Nerve Regeneration; Neurofibrils; Rats; Rats, Sprague-Dawley | 1996 |
Enhanced NMDAR-dependent epileptiform activity is controlled by oxidizing agents in a chronic model of temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dithionitrobenzoic Acid; Electric Stimulation; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Male; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuropeptides; Protons; Rats; Rats, Sprague-Dawley; Seizures; Temporal Lobe | 1997 |
Acute effects of MK801 on kainic acid-induced seizures in neonatal rats.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Time Factors | 1997 |
Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion' method.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Glutamic Acid; Hippocampus; Kainic Acid; Male; Microdialysis; Rats; Rats, Wistar; Seizures | 1997 |
Enhanced population responses in the basolateral amygdala of kainate-treated, epileptic rats in vitro.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; In Vitro Techniques; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 1997 |
Isolation of the gene encoding lamp-1, a lysosomal membrane protein, by differential screening in an animal model of status epilepticus.
Topics: Animals; Antigens, CD; Cycloheximide; Disease Models, Animal; Hippocampus; Kainic Acid; Limbic System; Lysosomal Membrane Proteins; Lysosomes; Male; Membrane Glycoproteins; Organ Specificity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Status Epilepticus; Transcription, Genetic | 1997 |
Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization.
Topics: Animals; Axons; Brain Mapping; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Kainic Acid; Male; Nerve Degeneration; Nerve Net; Nerve Regeneration; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kainic Acid; Male; Neuropeptide Y; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Seizures | 1997 |
Reversible model of magnesium depletion induced by systemic kainic acid injection in magnesium-deficient rats: I--Comparative study of various magnesium salts.
Topics: Administration, Oral; Animals; Disease Models, Animal; Food, Fortified; Injections, Intraperitoneal; Kainic Acid; Magnesium; Magnesium Deficiency; Male; Rats; Rats, Sprague-Dawley; Taurine | 1996 |
Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid.
Topics: Animals; Brain; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; HSP70 Heat-Shock Proteins; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; Peroxidases; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1997 |
[Experimental bilateral focus model of complex partial seizure: clinical, electrophysiological and pathological studies].
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Electrophysiology; Epilepsy, Complex Partial; Humans; Injections; Kainic Acid; Male; Rats; Rats, Wistar | 1997 |
Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat m1 and m3 muscarinic acetylcholine receptor genes.
Topics: Animals; Disease Models, Animal; Epilepsy, Generalized; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Receptors, Muscarinic | 1997 |
Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Behavior, Animal; Binding, Competitive; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamic Acid; In Situ Hybridization; Iodine Radioisotopes; Kainic Acid; Kinetics; Male; Mossy Fibers, Hippocampal; Peptide Fragments; Peptide YY; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; RNA, Messenger; Up-Regulation | 1998 |
Kainic acid lesions in adult rats as a model of schizophrenia: changes in auditory information processing.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Auditory Perception; Disease Models, Animal; Electrodes, Implanted; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Agonists; Haloperidol; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenia; Schizophrenic Psychology | 1998 |
Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Astrocytes; Brain Injuries; Brain Ischemia; Calcium Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gerbillinae; Glial Fibrillary Acidic Protein; Gliosis; Homeostasis; Hot Temperature; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Neurologic Mutants; Myelin Sheath; Rats; Up-Regulation; Wounds, Stab | 1998 |
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Maze Learning; Phenobarbital; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stress, Physiological; Valproic Acid | 1998 |
High-frequency stimulation of the subthalamic nucleus suppresses absence seizures in the rat: comparison with neurotoxic lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Kainic Acid; Male; Microinjections; Neurotoxins; Organ Specificity; Rats; Rats, Wistar; Thalamic Nuclei | 1998 |
Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Female; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Time Factors | 1998 |
Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Death; Demyelinating Diseases; Disease Models, Animal; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Optic Nerve; Optic Nerve Injuries; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Kainic Acid | 1998 |
Deficient sensorimotor gating following seizures in amygdala-kindled rats.
Topics: Acoustic Stimulation; Amygdala; Analysis of Variance; Animals; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Inhibition, Psychological; Kainic Acid; Kindling, Neurologic; Pentylenetetrazole; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Seizures | 1998 |
Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat.
Topics: Animals; Cycloheximide; Disease Models, Animal; Electroencephalography; Epilepsy; Evoked Potentials; GAP-43 Protein; Hippocampus; Kainic Acid; Nerve Fibers; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Transcription, Genetic | 1998 |
Hippocampal damage after injection of kainic acid into the rat entorhinal cortex.
Topics: Animals; Convulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microinjections; NADPH Dehydrogenase; Rats; Rats, Wistar; Somatostatin | 1998 |
Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cell Adhesion Molecules, Neuronal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Energy Metabolism; Epilepsy, Temporal Lobe; Fetal Proteins; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glucose; Hippocampus; Hypertrophy; Injections; Kainic Acid; Male; Mice; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neurons; Protein Isoforms; Sclerosis; Seizures; Silver Staining; Synapses | 1999 |
Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats.
Topics: Animals; Benzimidazoles; Calcium; Chelating Agents; Coloring Agents; Disease Models, Animal; Egtazic Acid; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mitochondria; NADP; Neurons; Organ Culture Techniques; Oxidative Phosphorylation; Oxygen Consumption; Potassium Chloride; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sodium-Potassium-Exchanging ATPase; Uncoupling Agents | 1999 |
Spontaneous motor seizures of rats with kainate-induced epilepsy: effect of time of day and activity state.
Topics: Animals; Behavior, Animal; Darkness; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Light; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Videotape Recording | 1999 |
Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Brain; Cyclooxygenase 2; Disease Models, Animal; Enzyme Induction; Ethanol; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; N-Methylaspartate; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1999 |
Long-term increase of Sp-1 transcription factors in the hippocampus after kainic acid treatment.
Topics: Animals; Antibodies; Brain Chemistry; Disease Models, Animal; DNA Primers; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Protein Binding; Rats; Rats, Inbred F344; Sp1 Transcription Factor | 1999 |
Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model.
Topics: Animals; Dietary Fats; Disease Models, Animal; Kainic Acid; Ketosis; Male; Mossy Fibers, Hippocampal; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Recurrence; Seizures | 1999 |
Consequences of cortical dysplasia during development in rats.
Topics: Amygdala; Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Epilepsy; Freezing; Functional Laterality; Hippocampus; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Mossy Fibers, Hippocampal; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 1999 |
Pharmacological evaluation of an in vivo model of vestibular dysfunction in the rat.
Topics: Animals; Betahistine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Histamine; Histamine Agonists; Histamine Antagonists; Imidazoles; Kainic Acid; Male; Microinjections; Rats; Rats, Long-Evans; Vestibular Diseases; Vestibular Nuclei | 1999 |
Regulation of calcium channel alpha(1A) subunit splice variant mRNAs in kainate-induced temporal lobe epilepsy.
Topics: Alternative Splicing; Animals; Brain; Calcium Channels; Calcium Channels, N-Type; Cerebellum; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Neocortex; Nerve Tissue Proteins; Protein Isoforms; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 1999 |
Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Functional Laterality; Hippocampus; Humans; Kainic Acid; Limbic System; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Telemetry | 1999 |
Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2.
Topics: Animals; Blotting, Northern; Brain; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; DNA-Binding Proteins; Early Growth Response Protein 1; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression; Glutamic Acid; Humans; Immediate-Early Proteins; Isoenzymes; Kainic Acid; Membrane Proteins; Mice; Mice, Transgenic; Neurons; Organ Specificity; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Transcription Factors | 1999 |
Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats.
Topics: Animals; Axonal Transport; Axons; Biomarkers; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Glutamate Decarboxylase; Interneurons; Kainic Acid; Male; Nerve Net; Neurons; Rats; Rats, Sprague-Dawley; Somatostatin; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1999 |
Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus.
Topics: Adenosine; Animals; Apoptosis; Disease Models, Animal; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Histocompatibility Antigens Class II; Injections, Intraventricular; Kainic Acid; Macrophage-1 Antigen; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neuroglia; Neurons; Phosphorylation; Proto-Oncogene Proteins c-jun; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Mice; N-Methylaspartate; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1999 |
A global hypoxia preconditioning model: neuroprotection against seizure-induced specific gravity changes (edema) and brain damage in rats.
Topics: Animals; Brain Edema; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hypoxia, Brain; Ischemic Preconditioning; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Wistar; Specific Gravity | 1999 |
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-End Labeling; Ischemic Attack, Transient; Ischemic Preconditioning; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenylisopropyladenosine; Potassium Channels; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Purinergic P1; Time Factors; Xanthines | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; PrPC Proteins; Seizures | 1999 |
Mapping of the progressive metabolic changes occurring during the development of hippocampal sclerosis in a model of mesial temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Energy Metabolism; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Kainic Acid; Male; Mice; Microinjections; Nerve Degeneration; Sclerosis | 2000 |
Amino acid neurotransmitter metabolism in neurones and glia following kainate injection in rats.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Neuroglia; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2000 |
Spatio-temporal profile of DNA fragmentation and its relationship to patterns of epileptiform activity following focally evoked limbic seizures.
Topics: Animals; Cell Death; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Functional Laterality; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 2000 |
Anti-seizure effects of progesterone and 3alpha,5alpha-THP in kainic acid and perforant pathway models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Epilepsy; Female; Kainic Acid; Ovariectomy; Perforant Pathway; Pregnanolone; Progesterone; Rats; Rats, Long-Evans | 2000 |
Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients.
Topics: Adult; Animals; Antibodies; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Up-Regulation | 2000 |
Reduction of A1 adenosine receptors in rat hippocampus after kainic acid-induced limbic seizures.
Topics: Adenosine; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Somatosensory Cortex | 2000 |
Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin.
Topics: Animals; Calbindin 2; Calbindins; Calcium-Binding Proteins; Carrier Proteins; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA Plasma Membrane Transport Proteins; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuropeptide Y; Organic Anion Transporters; Parvalbumins; Receptors, GABA-A; S100 Calcium Binding Protein G; Seizures; Somatostatin | 2000 |
Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain.
Topics: Amygdala; Animals; Basal Ganglia; Coloring Agents; Denervation; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; Fluorescent Dyes; Glutamic Acid; Hippocampus; Hypothalamus; Kainic Acid; Myelin Sheath; Nerve Degeneration; Neurons; Neurotoxins; Olfactory Pathways; Parietal Lobe; Phosphates; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Status Epilepticus; Thalamus; Time Factors | 2000 |
[Deficits of Morris water maze learning in rats with striatal kainic acid lesions].
Topics: Animals; Corpus Striatum; Disease Models, Animal; Female; Kainic Acid; Learning Disabilities; Maze Learning; Rats; Rats, Wistar | 2000 |
Estradiol facilitates kainic acid-induced, but not flurothyl-induced, behavioral seizure activity in adult female rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Estradiol; Female; Flurothyl; Hippocampus; Humans; Kainic Acid; Limbic System; Male; Neural Pathways; Progesterone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
Brain distribution and efficacy of carbamazepine in kainic acid induced seizure in rats.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Rats; Seizures; Time Factors | 2000 |
Magnetic resonance imaging follow-up of progressive hippocampal changes in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Diseases; Disease Models, Animal; Epilepsy, Temporal Lobe; Follow-Up Studies; Functional Laterality; Gadolinium; Hippocampus; Image Enhancement; Kainic Acid; Magnetic Resonance Imaging; Mice; Microinjections; Nerve Degeneration; Sclerosis; Seizures; Status Epilepticus | 2000 |
Recovery of kainic acid excitotoxicity in chinchilla cochlea.
Topics: Action Potentials; Animals; Chinchilla; Cochlear Nerve; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Agonists; Female; Hair Cells, Auditory, Inner; Kainic Acid; Male | 1999 |
Effects of hypoxia preconditioning on expression of metallothionein-1,2 and heme oxygenase-1 before and after kainic acid-induced seizures.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hippocampus; Hypoxia; Kainic Acid; Male; Metallothionein; Rats; Rats, Wistar; Seizures; Time Factors | 2000 |
Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats.
Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; In Vitro Techniques; Kainic Acid; Lysine; Male; Membrane Potentials; Microscopy, Electron; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2000 |
Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Calbindin 1; Calbindin 2; Calbindins; Carrier Proteins; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Functional Laterality; GABA Plasma Membrane Transport Proteins; Immunohistochemistry; Interneurons; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Organic Anion Transporters; Parvalbumins; Receptors, GABA-A; S100 Calcium Binding Protein G; Time Factors | 2000 |
Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures.
Topics: Animals; Brain; Cell Death; Disease Models, Animal; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Antagonists; Glutathione Peroxidase; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred Strains; Mice, Knockout; Neurons; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Compounds | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Lipid Peroxidation; Oxidative Stress; Pilocarpine; Rats; Rats, Wistar; Reactive Oxygen Species; Status Epilepticus; Thiobarbituric Acid Reactive Substances | 2000 |
Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration.
Topics: Age Factors; Animals; Autoradiography; Brain; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Flunitrazepam; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, GABA-A; Status Epilepticus; Tritium | 2000 |
Chromogranins in temporal lobe epilepsy.
Topics: Animals; Biomarkers; Chromogranins; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Mossy Fibers, Hippocampal; Neuropeptides; Rats; Secretogranin II | 2000 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Drug Design; Humans; Kainic Acid; Male; Mice; Molecular Structure; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Retina; Seizures; Structure-Activity Relationship | 2000 |
In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Hippocampus; Image Enhancement; Kainic Acid; Male; Oxidative Stress; Phantoms, Imaging; Pyrrolidines; Rats; Rats, Wistar; Reference Values; Seizures; Sensitivity and Specificity | 2000 |
[An animal model of non-hereditary Alzheimer's disease and its behavioral and pathologic changes].
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Basal Nucleus of Meynert; Disease Models, Animal; Kainic Acid; Prefrontal Cortex; Rats | 1997 |
Long-term increase of GluR2 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit in the dispersed dentate gyrus after intrahippocampal kainate injection in the mouse.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Time Factors | 2000 |
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Presenilin-1 | 2000 |
Effect of theophylline and trimethobenzamide when given during kainate-induced status epilepticus: an improved histopathologic rat model of human hippocampal sclerosis.
Topics: Animals; Benzamides; Brain Diseases; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Hypertension; Kainic Acid; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Sclerosis; Status Epilepticus; Theophylline | 2000 |
Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Cell Count; Cell Size; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Glutamate Decarboxylase; Graft Survival; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Interneurons; Isoenzymes; Kainic Acid; Male; Rats; Rats, Inbred F344 | 2000 |
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.
Topics: 3T3 Cells; Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Colchicine; Corpus Striatum; Disease Models, Animal; Fibroblasts; Fluorescent Dyes; Hippocampus; Huntington Disease; In Situ Hybridization; Kainic Acid; Male; Mice; Microinjections; Neural Pathways; Neurons; Nitro Compounds; Propionates; Quinolinic Acid; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger; Stilbamidines; Up-Regulation | 2001 |
Short- and long-term changes in CA1 network excitability after kainate treatment in rats.
Topics: Animals; Axons; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Time | 2001 |
Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains.
Topics: Animals; Brain; Cerebral Cortex; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Seizures | 2001 |
Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration.
Topics: Animals; Biomarkers; Citrulline; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hydrolases; Imines; Kainic Acid; Microtubule-Associated Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Rats; Rats, Wistar; Telencephalon | 2001 |
Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Laterality; Hippocampus; Indazoles; Injections, Intraperitoneal; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2001 |
Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities.
Topics: Animals; Cytoskeleton; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; SAP90-PSD95 Associated Proteins; Seizures; Subcellular Fractions; Synaptic Membranes; Tyrosine | 2001 |
Excitatory synaptic input to granule cells increases with time after kainate treatment.
Topics: Action Potentials; Animals; Bicuculline; Coloring Agents; Convulsants; Cytoplasmic Granules; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Photic Stimulation; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2001 |
Decreased epileptic susceptibility correlates with neuropeptide Y overexpression in a model of tolerance to excitotoxicity.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Neuropeptide Y; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar | 2001 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2001 |
Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2-dihydroquinoline (S 33113) in models of cerebral neurodegeneration.
Topics: Alloxan; Animals; Antioxidants; Body Temperature; Brain Ischemia; Cell Survival; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Hyperglycemia; Injections, Intraventricular; Kainic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nerve Degeneration; Neurons; Quinolines; Rats; Rats, Wistar; Rectum; Survival Rate; tert-Butylhydroperoxide | 2001 |
Long-lasting induction of brain-derived neurotrophic factor is restricted to resistant cell populations in an animal model of status epilepticus.
Topics: Animals; Apoptosis; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cell Death; Disease Models, Animal; Disease Susceptibility; Excitatory Amino Acid Agonists; Female; Kainic Acid; Neuroglia; Neurons; Rats; Rats, Wistar; RNA, Messenger; Status Epilepticus; Time Factors | 2001 |
Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Axotomy; Disease Models, Animal; Female; Gene Expression Regulation; Kainic Acid; Meninges; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Receptors, Nerve Growth Factor; RNA, Messenger; Schwann Cells; Spinal Cord; Spinal Cord Injuries; Wounds, Nonpenetrating | 2001 |
Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis.
Topics: Animals; Bicuculline; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; GABA Antagonists; Kainic Acid; Male; Membrane Potentials; Mossy Fibers, Hippocampal; Nerve Degeneration; Neural Inhibition; Neuronal Plasticity; Neurons; Perforant Pathway; Rats; Rats, Long-Evans; Synaptic Transmission | 2001 |
Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy.
Topics: Animals; Behavior, Animal; Cell Count; Cerebellar Diseases; Disease Models, Animal; Disease Progression; Glucose; Hippocampus; Immunohistochemistry; Injections, Subcutaneous; Insulin-Like Growth Factor I; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Olivary Nucleus; Physical Conditioning, Animal; Purkinje Cells; Pyridines; Rats; Rats, Wistar; Treatment Outcome | 2001 |
Ibotenate injections into the pre- and parasubiculum provide partial protection against kainate-induced epileptic damage in layer III of rat entorhinal cortex.
Topics: Animals; Convulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Ibotenic Acid; Kainic Acid; Male; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2001 |
Subthalamic nucleus lesions reduce low frequency oscillatory firing of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease.
Topics: Action Potentials; Animals; Biological Clocks; Disease Models, Animal; Excitatory Amino Acid Agonists; Kainic Acid; Male; Nerve Degeneration; Neural Pathways; Neurons; Neurotoxins; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra; Subthalamic Nucleus; Sympatholytics | 2001 |
Topiramate blocks perinatal hypoxia-induced seizures in rat pups.
Topics: Animals; Animals, Suckling; Anticonvulsants; Convulsants; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Fructose; Hippocampus; Hypoxia, Brain; Kainic Acid; Male; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Topiramate | 2001 |
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.
Topics: Animals; Antioxidants; Cell Count; Cell Death; Cerebral Cortex; Disease Models, Animal; DNA-Binding Proteins; DNA, Mitochondrial; Electron Transport; High Mobility Group Proteins; Hippocampus; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Mice, Neurologic Mutants; Mitochondrial Myopathies; Mitochondrial Proteins; Neurodegenerative Diseases; Neurons; Nuclear Proteins; Organ Specificity; Oxidative Phosphorylation; Reactive Oxygen Species; RNA; RNA, Mitochondrial; Transcription Factors | 2001 |
Gender differences in spontaneous and MK-801-induced activity after striatal lesions.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Huntington Disease; Hyperkinesis; Kainic Acid; Male; Motor Activity; Neostriatum; Neurons; Neurotoxins; Rats; Rats, Wistar; Sex Characteristics | 2001 |
A model of 'epileptic tolerance' for investigating neuroprotection, epileptic susceptibility and gene expression-related plastic changes.
Topics: Animals; Cell Death; Cell Survival; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Ischemic Preconditioning; Kainic Acid; Male; Neuronal Plasticity; Neuropeptide Y; Pyramidal Cells; Rats; Rats, Wistar; Status Epilepticus | 2002 |
Local generation of fast ripples in epileptic brain.
Topics: Action Potentials; Animals; Biological Clocks; Brain; Brain Mapping; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Evoked Potentials; Feedback; GABA Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microelectrodes; Neural Inhibition; Perforant Pathway; Rats; Rats, Sprague-Dawley; Reaction Time | 2002 |
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice.
Topics: Administration, Intranasal; Age Factors; Animals; Apoptosis; Behavior, Animal; Body Weight; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Isoenzymes; Kainic Acid; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Prostaglandin-Endoperoxide Synthases; Seizures; Survival Rate | 2002 |
Volumetric structural magnetic resonance imaging (MRI) of the rat hippocampus following kainic acid (KA) treatment.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Astrocytes; Avian Proteins; Basigin; Benzoxazines; Blood Proteins; Brain Mapping; Cell Count; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gyrus Cinguli; Hippocampus; Immunohistochemistry; Kainic Acid; Lateral Ventricles; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Microglia; Nerve Degeneration; Organic Chemicals; Oxazines; Rats; Rats, Sprague-Dawley | 2002 |
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Agonists; Glycoproteins; Hippocampus; Kainic Acid; Limbic System; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptides; Neuroserpin; Neurotoxins; Plasminogen; Plasminogen Activators; Rats; Rats, Sprague-Dawley; Seizures; Serine Proteinase Inhibitors; Serpins; Tissue Plasminogen Activator | 2002 |
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.
Topics: Action Potentials; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electric Stimulation; Electroshock; Epilepsy; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Isoquinolines; Kainic Acid; Limbic System; Male; Mice; Pilocarpine; Rats; Rats, Wistar; Receptors, Kainic Acid; Substrate Specificity; Treatment Outcome | 2002 |
Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes of the rat hippocampus following kainic acid-induced seizure.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Blotting, Western; Carrier Proteins; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Male; Neurons; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley | 2002 |
Sex differences in models of temporal lobe epilepsy: role of testosterone.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Hypothalamo-Hypophyseal System; Kainic Acid; Male; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Sex Characteristics; Testosterone | 2002 |
Amphetamine-induced locomotor activity and stereotypy after kainic acid lesions of the striatum.
Topics: Animals; Behavior; Choline O-Acetyltransferase; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Glutamate Decarboxylase; Humans; Kainic Acid; Male; Motor Activity; Pyrrolidines; Rats; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1978 |
Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntingdon's chorea.
Topics: Animals; Apomorphine; Behavior; Choline O-Acetyltransferase; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Glutamate Decarboxylase; Humans; Huntington Disease; Kainic Acid; Male; Nucleus Accumbens; Pyrrolidines; Rats; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1978 |
Impaired learning and memory after kainic acid lesions of the striatum: a behavioral model of Huntington's disease.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Glutamate Decarboxylase; Huntington Disease; Kainic Acid; Male; Memory; Mental Recall; Motor Activity; Pyrrolidines; Rats; Retention, Psychology; Tyrosine 3-Monooxygenase | 1978 |
Kainic acid lesions of the striatum: behavioural sequalae similar to Huntington's chorea.
Topics: Animals; Apomorphine; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Habituation, Psychophysiologic; Humans; Huntington Disease; Kainic Acid; Male; Motor Activity; Neurons; Nucleus Accumbens; Pyrrolidines; Rats; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1978 |
Intracerebral injections of kainic acid and tetanus toxin: possible models for the signs of chorea and dystonia.
Topics: Animals; Biogenic Amines; Brain Chemistry; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dystonia Musculorum Deformans; Glutamate Decarboxylase; Humans; Huntington Disease; Kainic Acid; Pyrrolidines; Rats; Substantia Nigra; Tetanus Toxin; Thalamus; Tyrosine 3-Monooxygenase | 1978 |
Kainic acid lesions of the striatum in rats mimic the spontaneous motor abnormalities of Huntington's Disease.
Topics: Animals; Behavior, Animal; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Glutamate Decarboxylase; Huntington Disease; Kainic Acid; Male; Motor Activity; Pimozide; Pyrrolidines; Rats; Tyrosine 3-Monooxygenase | 1979 |
An animal model for Huntington's disease.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Huntington Disease; Kainic Acid; Nerve Degeneration; Neural Pathways; Rats; Receptors, Neurotransmitter; Substantia Nigra; Tyrosine 3-Monooxygenase | 1979 |
[Epileptogenic action of intra-amygdaloid injection of kainic acid].
Topics: Amygdala; Animals; Diazepam; Disease Models, Animal; Hippocampus; Injections; Kainic Acid; Male; Pyrrolidines; Rats; Seizures; Status Epilepticus | 1978 |
Regional brain atrophy and reductions in glutamate release and uptake after intrastriatal kainic acid.
Topics: Animals; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Glutamate Decarboxylase; Glutamates; Huntington Disease; Kainic Acid; Male; Pyrrolidines; Rats | 1978 |
Effect of 2-dimethylaminoethanol in kainate-lesioned rat striatum: anomaly in the radioenzymatic assay of acetylcholine.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Chromatography, Gas; Corpus Striatum; Deanol; Disease Models, Animal; Ethanolamines; Huntington Disease; Kainic Acid; Male; Phosphorus Radioisotopes; Pyrrolidines; Rats | 1978 |
Huntington's disease and its animal model: alterations in kainic acid binding.
Topics: Animals; Binding Sites; Caudate Nucleus; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Huntington Disease; Kainic Acid; Kinetics; Male; Putamen; Pyrrolidines; Rats; Synaptic Membranes; Time Factors | 1979 |
Sedative effects of apomorphine in an animal model of Huntington's disease.
Topics: Animals; Apomorphine; Corpus Striatum; Dextroamphetamine; Disease Models, Animal; Humans; Huntington Disease; Kainic Acid; Male; Motor Activity; Rats; Receptors, Dopamine; Stereotyped Behavior | 1979 |
Body weight, feeding, and drinking behaviors in rats with kainic acid-induced lesions of striatal neurons--with a note on body weight symptomatology in Huntington's disease.
Topics: Animals; Body Weight; Brain Diseases; Corpus Striatum; Disease Models, Animal; Drinking Behavior; Feeding Behavior; Huntington Disease; Kainic Acid; Male; Pyrrolidines; Rats | 1979 |
Kainic acid animal model predicts therapeutic agents in Huntington's chorea.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Huntington Disease; Kainic Acid; Male; Pyrrolidines; Rats | 1979 |
Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: correlates with a new animal model.
Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Huntington Disease; Kainic Acid; Pyrrolidines; Rats; Receptors, Cholinergic; Substantia Nigra; Synaptic Transmission | 1977 |
Neuroscientists begin to piece together more parts of Huntington's disease puzzle.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Chemistry; Disease Models, Animal; Fibroblast Growth Factors; Humans; Huntington Disease; Ibotenic Acid; Kainic Acid; Lactates; Lactic Acid; Rats | 1992 |
Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity.
Topics: Animals; Basal Ganglia Diseases; Biogenic Amines; Calbindin 1; Calbindins; Calcium; Cell Survival; Disease Models, Animal; Kainic Acid; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; RNA, Messenger; S100 Calcium Binding Protein G | 1992 |
Seizure circuit analysis with voltage sensitive dye.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Brain; Brain Mapping; Disease Models, Animal; Fluorescent Dyes; Kainic Acid; Limbic System; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Hippocampal CA3 lesion prevents postconcussive metabolic dysfunction in CA1.
Topics: Animals; Brain Concussion; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 1992 |
Kainic acid-induced thalamic seizure in cats--a possible model of petit mal seizure.
Topics: Animals; Cats; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; Kainic Acid; Male; Seizures; Stereotaxic Techniques; Thalamic Nuclei; Thalamus | 1992 |
Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats.
Topics: Action Potentials; Afferent Pathways; Animals; Axons; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Synapses | 1992 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamates; Huntington Disease; Ibotenic Acid; Kainic Acid; Male; Mesencephalon; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Values; Somatostatin; Substance P | 1991 |
Selective reduction of oscillatory potentials and pattern electroretinograms after retinal ganglion cell damage by disease in humans or by kainic acid toxicity in cats.
Topics: Action Potentials; Animals; Cats; Dark Adaptation; Disease Models, Animal; Electroretinography; Glaucoma; Humans; Kainic Acid; Middle Aged; Ocular Hypertension; Optic Nerve Diseases; Oscillometry; Pattern Recognition, Visual; Photic Stimulation; Retinal Ganglion Cells | 1991 |
Selectivity of kainic acid as a neurotoxin within the dorsal lateral geniculate nucleus of the cat: a model for transneuronal retrograde degeneration.
Topics: Animals; Cats; Disease Models, Animal; Geniculate Bodies; Horseradish Peroxidase; Kainic Acid; Microscopy, Electron; Nerve Degeneration; Retina; Visual Pathways | 1991 |
Partial hippocampal pyramidal cell loss alters behavior in rats: implications for an animal model of schizophrenia.
Topics: Analysis of Variance; Animals; Avoidance Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Grooming; Hippocampus; Kainic Acid; Male; Motor Activity; Pyramidal Tracts; Rats; Rats, Inbred Strains; Schizophrenia; Schizophrenic Psychology; Stereotyped Behavior | 1991 |
Sensitive murine model and putative antidotes for behaviorial toxicosis from contaminated mussel extracts.
Topics: Age Factors; Animals; Antidotes; Behavior, Animal; Bivalvia; Disease Models, Animal; Kainic Acid; Male; Marine Toxins; Mice; Nervous System Diseases; Neurotoxins | 1990 |
Some mechanisms of brain edema studied in a kainic acid model.
Topics: Animals; Brain Edema; Disease Models, Animal; Kainic Acid; Limbic System; Neurons; Rats; Seizures | 1990 |
T1 and T2 weighted magnetic resonance imaging of excitotoxin lesions and neural transplants in rat brain in vivo.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Kainic Acid; Magnetic Resonance Imaging; Male; Rats; Rats, Inbred Strains | 1990 |
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Isoquinolines; Kainic Acid; Male; Mice; Nerve Degeneration; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Kainic acid and formoguanamine effects on environmentally-induced eye lesions in chicks.
Topics: Animals; Blindness; Chickens; Cornea; Disease Models, Animal; Glaucoma; Kainic Acid; Light; Myopia; Organ Size; Oxadiazoles; Quisqualic Acid; Retina; Triazines; Vision, Ocular | 1990 |
Combined kainate and ischemia produces 'mesial temporal sclerosis'.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Sclerosis; Temporal Lobe | 1990 |
[Acute effect of penicillin G on feline models of focal epilepsy].
Topics: Amygdala; Animals; Cats; Convulsants; Disease Models, Animal; Epilepsies, Partial; Injections, Intraperitoneal; Kainic Acid; Kindling, Neurologic; Limbic System; Penicillin G; Reaction Time; Seizures | 1989 |
Intraparenchymal striatal transplants required for maintenance of behavioral recovery in an animal model of Huntington's disease.
Topics: Analysis of Variance; Animals; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Electroshock; Huntington Disease; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains | 1989 |
Hippocampal plasticity in the kindling model of epilepsy in rats.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reference Values | 1989 |
Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease.
Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Humans; Huntington Disease; Ibotenic Acid; Immune Sera; Immunoassay; Kainic Acid; Male; Neurons; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin; Tissue Distribution | 1985 |
[Activity of substantia nigra pars reticulata neurons after lesion of the ipsilateral neostriatum by kainic acid in rats].
Topics: Animals; Caudate Nucleus; Disease Models, Animal; Electrophysiology; Huntington Disease; Kainic Acid; Male; Neurons; Putamen; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Neonatal striatal grafts prevent lethal syndrome produced by bilateral intrastriatal injection of kainic acid.
Topics: Animals; Animals, Newborn; Basal Ganglia Diseases; Corpus Striatum; Disease Models, Animal; Female; Huntington Disease; Kainic Acid; Rats; Rats, Inbred Lew | 1986 |
Locomotor hyperactivity: effects of multiple striatal transplants in an animal model of Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fetus; Huntington Disease; Kainic Acid; Male; Rats | 1986 |
Experimental striatal degeneration induced by kainic acid administration: relevance to morphological changes in Huntington's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Kainic Acid; Male; Microinjections; Microscopy, Electron; Nerve Degeneration; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1986 |
Intraparenchymal fetal striatal transplants and recovery in kainic acid lesioned rats.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fetus; Huntington Disease; Kainic Acid; Motor Activity; Rats | 1988 |
Epileptic phenomena produced by kainic acid in laboratory rats during ontogenesis.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains | 1988 |
Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Kainic Acid; Male; Neural Inhibition; Rats; Rats, Inbred Strains; Synaptic Transmission | 1986 |
An animal model for neuron-specific spinal cord lesions by the microinjection of N-methylaspartate, kainic acid, and quisqualic acid.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Forelimb; Ganglia, Spinal; Hindlimb; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission | 1985 |
Inciting excitotoxic cytocide among central neurons.
Topics: Action Potentials; Animals; Brain; Cell Survival; Chick Embryo; Cholinergic Fibers; Disease Models, Animal; Edema; Epilepsies, Partial; Folic Acid; Hippocampus; Hypoxia; Kainic Acid; Ketamine; Microscopy, Electron; Parasympathomimetics; Phencyclidine; Piperidines; Seizures; Synaptic Transmission; Thalamus | 1986 |
Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid.
Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seizures | 1988 |
[Regional cerebral blood flow during development of limbic seizures induced by kainic acid (KA) microinjection into unilateral amygdala in chronic cats].
Topics: Amygdala; Animals; Astrocytes; Cats; Cell Division; Cerebrovascular Circulation; Chronic Disease; Disease Models, Animal; Hippocampus; Hydrogen; Kainic Acid; Limbic System; Microinjections; Seizures | 1988 |
Kynurenate inhibition of cell excitation decreases stroke size and deficits.
Topics: Animals; Blood Pressure; Disease Models, Animal; Ischemic Attack, Transient; Kainic Acid; Male; Rats; Rats, Inbred Strains | 1987 |
Brain damage caused by seizure activity.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Limbic System; Rats; Seizures | 1987 |
Wet dog shakes in limbic versus generalized seizures.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Limbic System; Oxadiazoles; Quisqualic Acid; Rats | 1987 |
[Modelling of the parkinsonian syndrome by the administration of kainic acid into the caudate nucleus].
Topics: Animals; Caudate Nucleus; Disease Models, Animal; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Female; Injections; Kainic Acid; Levodopa; Male; Parkinson Disease, Secondary; Rats; Time Factors; Trihexyphenidyl | 1987 |
Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Disease Models, Animal; Fetus; Glutamate Decarboxylase; Kainic Acid; Rats; Substantia Innominata | 1986 |
Electrocerebral and behavioural analysis of systemic kainic acid-induced epilepsy in the rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Rats; Rats, Inbred Strains | 1986 |