kainic acid has been researched along with Degenerative Diseases, Central Nervous System in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.39) | 18.2507 |
| 2000's | 32 (44.44) | 29.6817 |
| 2010's | 37 (51.39) | 24.3611 |
| 2020's | 2 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Akkulak, A; Donmez Yalcin, G; Yalcin, A; Yeşilören, E | 1 |
| Cho, E; Choi, Y; Hwang, H; Jang, J; Kim, S; Koh, HY; Lee, AR; Lee, J; Park, M; Seo, J; Sohn, H | 1 |
| Liu, H; Wang, J; Zhang, M; Zhao, Y | 1 |
| Gu, Q; Kanungo, J; Paule, MG; Raymick, J; Sarkar, S; Smani, D | 1 |
| Baharvand, H; Ghasemi-Kasman, M; Javan, M | 1 |
| Banerjee, M; Hariharakrishnan, J; Kar, S; Kodam, A; Maulik, M; Ourdev, D; Wang, Y | 1 |
| Chiu, KM; Lee, MY; Lin, TY; Lu, CW; Wang, MJ; Wang, SJ | 1 |
| Kirazli, O; Onat, F; Sakalli, E; Sehirli, US; Tezcan, K | 1 |
| Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galli, F; Lattanzi, D; Marinelli, R; Minelli, A; Torquato, P | 1 |
| Adem, A; Amir, N; Azimullah, S; Hasan, MY; Ruan, Y; Sharkawi, SS; Zhang, XM; Zheng, XY; Zhu, J | 1 |
| Kuruba, R; Reddy, DS | 1 |
| Christensen, A; Hattersley, G; Jayaraman, A; Miller, CP; Moser, VA; Pike, CJ; Vest, RS | 1 |
| Amankulor, N; Feng, X; Ghosal, K; Hambardzumyan, D; Holland, EC; Pitter, KL; Tamagno, I | 1 |
| Bhowmik, M; Saini, N; Vohora, D | 1 |
| Bhowmik, M; Pottoo, FH; Vohora, D | 1 |
| Li, Y; Xing, H; Ye, Y | 1 |
| Govindasamy, C; Mustapha, Z; Sirajudeen, KN; Suhaili, D; Swamy, M | 1 |
| Bhowmik, M; Khanam, R; Saini, N; Vohora, D | 1 |
| Alberi, L; Brai, E; Kaczarowski, M; Liu, S; Marathe, S | 1 |
| Arthur, JM; Bell, PD; Gulland, FM; Janech, MG; Kindy, M; Neely, BA; Soper, JL | 1 |
| Bitsika, V; Depaulis, A; Duveau, V; Makridakis, M; Mermelekas, G; Mullen, W; Roucard, C; Savvopoulos, P; Simon-Areces, J; Vlahou, A | 1 |
| Morales, T; Reyes-Mendoza, J | 1 |
| García-Sevilla, JA; Keller, B | 1 |
| Chen, YC; Jiang, Y; Shi, L; Wang, X; Zhang, JG; Zhang, X; Zhu, GY | 1 |
| Bauer, S; Costard, L; Kienzler-Norwood, F; Müller, P; Neubert, V; Norwood, BA; Rosenow, F; Sadangi, C | 1 |
| Carrión, AM; Delgado-García, JM; Fontán-Lozano, A; Múnera, A; Romero-Granados, R; Troncoso, J | 1 |
| Cho, GJ; Cho, YW; Choi, WS; Jeon, BT; Jeong, EA; Kang, SS; Kim, HJ; Kim, JS; Lee, DH; Roh, GS | 1 |
| Jin, T; Mix, E; Quezada, HC; Winblad, B; Zhang, XM; Zhu, J | 1 |
| Branshaw, S; Brown-Borg, HM; Haselton, J; Rakoczy, S; Sharma, S | 1 |
| Camins, A; Canudas, AM; Crespo-Biel, N; Pallàs, M | 1 |
| Cross, CA; Ryan, JC; Van Dolah, FM | 1 |
| Luo, Q; Zhang, HL; Zheng, XY; Zhu, J | 1 |
| Aigner, C; Herzog, H; Schunk, E; Schwarzer, C; Stefanova, N; Wenning, G | 1 |
| Adem, A; Mao, XJ; Mix, E; Pham, T; Winblad, B; Zhang, HL; Zhang, XM; Zheng, XY; Zhu, J | 1 |
| Cheng, W; Hu, B; Lu, J; Wu, DM; Zhang, ZF; Zheng, YL | 1 |
| Charbord, P; Delorme, B; Diem, R; Evangelidou, M; Fairless, R; Karamita, M; Kyrargyri, V; Probert, L; Tseveleki, V; Voulgari-Kokota, A | 1 |
| Hattiangady, B; Shetty, AK | 1 |
| Alabsi, H; Britschgi, M; Ding, Z; Elwood, F; Fainberg, N; Gambhir, SS; Getachew, R; James, ML; Luo, J; Narasimhan, R; Pollard, JW; Relton, J; Villeda, S; Wabl, R; Wong, G; Wyss-Coray, T; Zhang, H; Zhu, L | 1 |
| Cederroth, CR; Kruyer, A; Lowry, ER; Norris, EH; Strickland, S | 1 |
| Uccelli, A | 1 |
| Benkovic, SA; Miller, DB; O'Callaghan, JP; Sriram, K | 1 |
| Bladin, C; Liberatore, GT; Medcalf, RL; Samson, A; Schleuning, WD | 1 |
| Dawson, TM; Dike, S; Fannjiang, Y; Griffin, DE; Hardwick, JM; Huganir, RL; Jonas, EA; Kaczmarek, LK; Kerr, DA; Kim, CH; Larsen, T; Lindsten, T; Mandir, AS; Mito, T; Sappington, AL; Thompson, CB; Traystman, RJ; Zou, S | 1 |
| Fernandez, SR; Siao, CJ; Tsirka, SE | 1 |
| Ananth, C; Gopalakrishnakone, P; Kaur, C | 1 |
| Bakhiet, M; Chen, Z; Winblad, B; Yu, S; Zhu, J | 1 |
| Shetty, AK; Zaman, V | 1 |
| Cano, J; Machado, A; Rite, I; Tomás-Camardiel, M; Venero, JL | 1 |
| Chen, Z; Concha, HQ; Ljunggren, HG; Mix, E; Winblad, B; Yu, S; Zhu, J; Zhu, Y | 1 |
| Liang, LP; Patel, M | 1 |
| Farooqui, AA; Horrocks, LA; Ong, WY | 1 |
| Gobbo, OL; O'Mara, SM | 1 |
| Gides, JJ; Kalehua, AN; Kusiak, JW; Nagel, JE; Pyle, RS; Smith, RJ; Taub, DD; Whelchel, LM | 1 |
| Carrasco, J; Florit, S; Giralt, M; Hidalgo, J; Molinero, A; Penkowa, M; Quintana, A | 1 |
| Higuchi, M; Itohara, S; Iwata, N; Maki, M; Masumoto, H; Saido, TC; Shirotani, K; Takano, J; Tomioka, M | 1 |
| Simonyi, A; Sun, AY; Sun, GY; Wang, Q; Yu, S | 1 |
| Coyle, JT | 1 |
| Agostino, A; Dell'agnello, C; Leo, S; Prelle, A; Rizzuto, R; Roubertoux, P; Szabadkai, G; Tiveron, C; Zeviani, M; Zulian, A | 1 |
| Bogenhagen, DF; Gravanis, I; Rogove, AD; Sheehan, JJ; Tsirka, SE; Wu, YP; Zhou, C | 1 |
| Adem, A; Jin, T; Lu, MO; Mix, E; Quezada, HC; Zhang, XM; Zhu, J | 1 |
| Baudry, M; Musleh, W; Pasinetti, GM; Sakhi, S; Schreiber, SS; Tocco, G | 1 |
| Chase, TN; Nakai, M; Qin, Z; Wang, Y | 1 |
| Bouilleret, V; Celio, MR; Fritschy, JM; Schurmans, S; Schwaller, B | 1 |
| de Kloet, ER; Grootendorst, J; Haasdijk, E; Jaarsma, D; Mulder, M | 1 |
| Nijjar, MS; Nijjar, SS | 1 |
| Czyrak, A; Fijał, K; Maćkowiak, M; Wedzony, K; Zajaczkowski, W | 1 |
| Hirai, H; Kurokawa, K; Matsuda, M; Onteniente, B; Riban, V; Suzuki, F | 1 |
| Levid, J; Schreiber, SS; Tan, Z | 1 |
| Busiguina, S; Carro, E; Torres-Aleman, I; Trejo, JL | 1 |
| Ekstrand, M; Larsson, NG; Lindqvist, E; Olson, L; Rustin, P; Silva, JP; Sörensen, L; Xu, B | 1 |
| Jin, S; Lee, WL; Ng, YK; Wong, PT; Zhu, X | 1 |
| Bogdanovic, N; Chen, Z; Ljunggren, HG; Nennesmo, I; Winblad, B; Zhu, J | 1 |
7 review(s) available for kainic acid and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.
Topics: Animals; Antioxidants; Brain; Epilepsy; Humans; Inflammation; Kainic Acid; Neurodegenerative Diseases; Oxidative Stress; Vitamin E | 2019 |
Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions.
Topics: Animals; Convulsants; Electric Stimulation Therapy; Flurothyl; Humans; Kainic Acid; Neurodegenerative Diseases; Perforant Pathway; Pilocarpine; Status Epilepticus | 2013 |
Kainic acid-induced neurodegenerative model: potentials and limitations.
Topics: Animals; Disease Models, Animal; Kainic Acid; Neurodegenerative Diseases; Receptors, Kainic Acid; Signal Transduction | 2011 |
Neuroprotection abilities of cytosolic phospholipase A2 inhibitors in kainic acid-induced neurodegeneration.
Topics: Animals; Blood Proteins; Cytosol; Humans; Kainic Acid; Neurodegenerative Diseases; Neuroprotective Agents; Phospholipases A; Phospholipases A2 | 2004 |
Kainic acid-mediated excitotoxicity as a model for neurodegeneration.
Topics: Animals; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Models, Biological; Neurodegenerative Diseases; Oxidative Stress | 2005 |
Glial metabolites of tryptophan and excitotoxicity: coming unglued.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Humans; Kainic Acid; Kynurenine; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuroglia; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2006 |
Domoic acid-induced neurodegeneration resulting in memory loss is mediated by Ca2+ overload and inhibition of Ca2+ + calmodulin-stimulated adenylate cyclase in rat brain (review).
Topics: Adenylyl Cyclases; Animals; Brain; Calcium; Calmodulin; Kainic Acid; Memory; Memory Disorders; Neurodegenerative Diseases; Neurotoxins; Rats | 2000 |
65 other study(ies) available for kainic acid and Degenerative Diseases, Central Nervous System
| Article | Year |
|---|---|
Kainic Acid-Induced Excitotoxicity Leads to the Activation of Heat Shock Response.
Topics: DNA-Binding Proteins; Glutamic Acid; Heat Shock Transcription Factors; Heat-Shock Response; Humans; Kainic Acid; Neurodegenerative Diseases; Transcription Factors | 2023 |
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Topics: Animals; Brain Chemistry; Cells, Cultured; Computational Biology; Cyclins; Epilepsy; Excitatory Amino Acid Agonists; Female; Genotype; Hippocampus; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Reelin Protein; RNA-Seq | 2020 |
Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration.
Topics: Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type I; Growth Differentiation Factor 5; Hippocampus; Kainic Acid; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Recombinant Proteins; RNA, Messenger; Signal Transduction | 2017 |
Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model.
Topics: 14-3-3 Proteins; Animals; Disease Models, Animal; Down-Regulation; Frontal Lobe; Kainic Acid; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley | 2018 |
Enhanced neurogenesis in degenerated hippocampi following pretreatment with miR-302/367 expressing lentiviral vector in mice.
Topics: Animals; Hippocampus; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Neurodegenerative Diseases; Neurogenesis; Neurons; Valproic Acid | 2017 |
A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2019 |
Ropivacaine Protects against Memory Impairment and Hippocampal Damage in a Rat Neurodegeneration Model.
Topics: Animals; Apoptosis; Caspase 3; Cell Death; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Memory Disorders; Mitogen-Activated Protein Kinases; Neurodegenerative Diseases; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Ropivacaine; Spatial Memory | 2018 |
Differences in Neurodegeneration Between Kainic Acid-Injected GAERS and Wistar Rats.
Topics: Amygdala; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agonists; Kainic Acid; Male; Neurodegenerative Diseases; Rats; Rats, Wistar; Species Specificity | 2019 |
Possible protecting role of TNF-α in kainic acid-induced neurotoxicity via down-regulation of NFκB signaling pathway.
Topics: Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Knockout; Neurodegenerative Diseases; NF-kappa B; Seizures; Signal Transduction; Tumor Necrosis Factor-alpha | 2013 |
Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.
Topics: Acetanilides; Animals; Apoptosis; Cell Survival; Cells, Cultured; Female; Hippocampus; Hormone Antagonists; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Nitriles; Oxadiazoles; Rats; Rats, Sprague-Dawley; Risk; Signal Transduction | 2014 |
The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions.
Topics: Animals; Astrocytes; Cell Proliferation; Central Nervous System Agents; Disease Models, Animal; Hedgehog Proteins; Hippocampus; Kainic Acid; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Neurogenesis; Neurons; Seizures; Severity of Illness Index; Signal Transduction; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2014 |
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice.
Topics: Animals; Anticonvulsants; Benzofurans; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Histamine H3 Antagonists; Kainic Acid; Male; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Protein Kinase Inhibitors; Pyrrolidines; Random Allocation; Seizures; Thiadiazoles; Valproic Acid | 2014 |
Raloxifene protects against seizures and neurodegeneration in a mouse model mimicking epilepsy in postmenopausal woman.
Topics: Animals; Bone Density; Cyclohexenes; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Neurodegenerative Diseases; Neurons; Postmenopause; Raloxifene Hydrochloride; Seizures; Transforming Growth Factor beta3; Vinyl Compounds | 2014 |
Nanoencapsulation of the sasanquasaponin from Camellia oleifera, its photo responsiveness and neuroprotective effects.
Topics: Animals; Behavior, Animal; Brain; Camellia; Chlorophyll; Cytokines; Disease Models, Animal; Kainic Acid; Light; Male; Mice; Mice, Inbred C57BL; Nanocapsules; Neurodegenerative Diseases; Neuroprotective Agents; Particle Size; Photosensitizing Agents; Saponins; Tyrosine 3-Monooxygenase | 2014 |
Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain.
Topics: Animals; Apitherapy; Apoptosis; Brain; Caspase 3; Dietary Supplements; Kainic Acid; Male; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Nitric Oxide Synthase; Propolis; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2014 |
Activation of AKT/GSK3β pathway by TDZD-8 attenuates kainic acid induced neurodegeneration but not seizures in mice.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain; Caspase 3; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Kainic Acid; Male; Mice; Neurodegenerative Diseases; Oncogene Protein v-akt; Proto-Oncogene Proteins c-bcl-2; Seizures; Signal Transduction; Thiadiazoles | 2015 |
Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry.
Topics: Animals; Blotting, Western; Cell Cycle; Cells, Cultured; Cyclin D1; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunohistochemistry; Immunoprecipitation; Kainic Acid; Mice; Neurodegenerative Diseases; Proto-Oncogene Proteins c-akt; Receptors, Notch; Signal Transduction | 2015 |
Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration.
Topics: Animals; Kainic Acid; Neurodegenerative Diseases; Proteomics; Reelin Protein; Sea Lions | 2015 |
High-Throughput LC-MS/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; High-Throughput Screening Assays; Kainic Acid; Mice; Microglia; Neurodegenerative Diseases; Proteome; Proteomics; Synaptic Transmission; Tandem Mass Spectrometry; Time Factors | 2016 |
Post-treatment with prolactin protects hippocampal CA1 neurons of the ovariectomized female rat against kainic acid-induced neurodegeneration.
Topics: Animals; Antigens, Nuclear; Astrocytes; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Female; Gliosis; Kainic Acid; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurogenesis; Neurons; Neuroprotective Agents; Ovariectomy; Prolactin; Random Allocation; Rats; Time Factors | 2016 |
Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice.
Topics: Animals; Benzofurans; Cerebral Cortex; Cyclin-Dependent Kinase 5; Glutamic Acid; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Kainic Acid; Ligands; Male; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Styrenes; Time Factors | 2016 |
Deep brain stimulation of the anterior nucleus of the thalamus reverses the gene expression of cytokines and their receptors as well as neuronal degeneration in epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cytokines; Deep Brain Stimulation; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression; Kainic Acid; Male; Microscopy, Electron, Transmission; Neurodegenerative Diseases; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytokine | 2017 |
A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Humans; Kainic Acid; Lorazepam; Male; Mossy Fibers, Hippocampal; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley; Sclerosis; Video Recording | 2017 |
Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice.
Topics: Acetylation; Aging; Analysis of Variance; Animals; Association Learning; Blinking; Conditioning, Classical; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kainic Acid; Male; Memory; Mice; Mice, Mutant Strains; Neurodegenerative Diseases; Pattern Recognition, Visual; Time Factors | 2008 |
Altered expression of sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 in mouse hippocampus after kainic acid treatment.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurodegenerative Diseases; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid | 2010 |
Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice.
Topics: Aging; Animals; Brain; Excitatory Amino Acid Agonists; Female; Flow Cytometry; Immunohistochemistry; Interleukin-10; Interleukin-18; Interleukin-6; Kainic Acid; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Motor Activity; Neurodegenerative Diseases; Seizures; Tumor Necrosis Factor-alpha | 2010 |
Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neurodegeneration.
Topics: Animals; Cognition; Cognition Disorders; Female; Gene Expression; Hippocampus; Insulin-Like Growth Factor I; Kainic Acid; Longevity; Male; Maze Learning; Memory; Mice; Mice, Mutant Strains; Neurodegenerative Diseases | 2010 |
Kainate-induced toxicity in the hippocampus: potential role of lithium.
Topics: Animals; Calcium; Calpain; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase 5; Disease Models, Animal; Glycogen Synthase Kinases; Hippocampus; Kainic Acid; Lithium Chloride; Male; Mice; Mice, Inbred Strains; Neurodegenerative Diseases; Neuroprotective Agents; Phosphorylation; tau Proteins | 2010 |
Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid.
Topics: Animals; Aspirin; Cell Survival; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Administration Schedule; Hippocampus; Indans; Kainic Acid; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Neurodegenerative Diseases; Neurons; Neurotoxins | 2011 |
Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; CA1 Region, Hippocampal; Enkephalins; Guanidines; Humans; Interneurons; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphinans; Neurodegenerative Diseases; Protein Precursors; Pyramidal Cells; Receptors, Opioid, kappa; Seizures | 2011 |
Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration.
Topics: Analysis of Variance; Animals; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Astrocytes; CD11b Antigen; Cytokines; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Exploratory Behavior; Flow Cytometry; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Seizures; Statistics, Nonparametric | 2012 |
Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice.
Topics: Animals; Anthocyanins; Apoptosis; Catalase; Cognition Disorders; Endoplasmic Reticulum Stress; Estrogen Receptor alpha; Hippocampus; Ipomoea batatas; Kainic Acid; Male; Maze Learning; Mice; Mice, Inbred ICR; Mitochondria; NADPH Oxidases; Neurodegenerative Diseases; Neuroprotective Agents; Nuclear Respiratory Factor 1; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Plant Extracts; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Trans-Activators; Transcription Factors; Up-Regulation | 2012 |
Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function.
Topics: Animals; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Female; Glutamic Acid; Kainic Acid; Male; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Neurons; Pregnancy | 2012 |
Neural stem cell grafting counteracts hippocampal injury-mediated impairments in mood, memory, and neurogenesis.
Topics: Animals; Cell Proliferation; Dentate Gyrus; Hippocampus; Intercellular Signaling Peptides and Proteins; Kainic Acid; Male; Memory Disorders; Mood Disorders; Neural Stem Cells; Neurodegenerative Diseases; Neurogenesis; Rats; Rats, Sprague-Dawley; Reelin Protein | 2012 |
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.
Topics: Amyloid beta-Protein Precursor; Animals; Base Sequence; Cell Survival; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Humans; Interleukins; Kainic Acid; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Phosphorylation; Prosencephalon; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction | 2013 |
The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration.
Topics: Affect; Animals; Blotting, Western; Brain Ischemia; CA3 Region, Hippocampal; Cell Death; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Agonists; Hippocampus; Hypoxia, Brain; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Maze Learning; Memory; Mice; Mice, Knockout; Microinjections; Motor Activity; Neurodegenerative Diseases; Neurons; Receptors, Kainic Acid; Reflex, Startle; Stereotaxic Techniques; Stroke | 2013 |
Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration: commentary on: "Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function" by Voulg
Topics: Animals; Female; Kainic Acid; Male; Mesenchymal Stem Cell Transplantation; Neurodegenerative Diseases; Pregnancy | 2013 |
Obesity exacerbates chemically induced neurodegeneration.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Dopamine; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Ion Channels; Kainic Acid; Membrane Transport Proteins; Methamphetamine; Mice; Mice, Obese; Microtubule-Associated Proteins; Mitochondrial Proteins; Neostriatum; Neurodegenerative Diseases; Neurons; Neurotoxicity Syndromes; Neurotoxins; Obesity; Presynaptic Terminals; Proteins; Uncoupling Protein 2 | 2002 |
Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration.
Topics: Animals; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Fibrinolytic Agents; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Plasminogen Activators; Tissue Plasminogen Activator | 2003 |
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Central Nervous System; Central Nervous System Diseases; Central Nervous System Viral Diseases; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Genetic Vectors; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neurons; Neurotoxins; Protein Structure, Tertiary; Sindbis Virus; Stroke; Synaptic Transmission | 2003 |
Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury.
Topics: Animals; Cell Count; Cells, Cultured; Disease Progression; Gene Expression; Genes, fms; Genetic Predisposition to Disease; Kainic Acid; Mice; Mice, Knockout; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Neurofilament Proteins; Neurons; Neurotoxins; Organ Specificity; Promoter Regions, Genetic; Tissue Plasminogen Activator | 2003 |
Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Astrocytes; Avian Proteins; Basigin; Blood Proteins; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Melatonin; Membrane Glycoproteins; Microglia; Microscopy, Electron; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; RNA, Messenger | 2003 |
The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3.
Topics: Animals; Cell Survival; Cells, Cultured; Disease Progression; Excitatory Amino Acid Agonists; Hippocampus; Inflammation Mediators; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Neurons; Receptors, CCR2; Receptors, CCR3; Receptors, CCR5; Receptors, Chemokine; RNA, Messenger | 2003 |
Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor-2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Division; Disease Models, Animal; Epilepsy, Temporal Lobe; Fetus; Fibroblast Growth Factor 2; Graft Survival; Hippocampus; Kainic Acid; Male; Memory Disorders; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Phenotype; Rats; Rats, Inbred F344; Stem Cells | 2003 |
Expression of BDNF mRNA in substantia nigra is dependent on target integrity and independent of neuronal activation.
Topics: Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Colchicine; Female; Kainic Acid; Medial Forebrain Bundle; Neurodegenerative Diseases; Neurons; Neurotoxins; Quinolinic Acid; Rats; Rats, Wistar; Receptor, trkB; RNA, Messenger; Substantia Nigra; Subthalamic Nucleus; Up-Regulation | 2003 |
Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis.
Topics: Animals; B-Lymphocyte Subsets; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Neurotoxins; Seizures; T-Lymphocyte Subsets | 2004 |
Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.
Topics: Aconitate Hydratase; Amino Acid Transport System X-AG; Animals; Deoxyadenosines; Epilepsy; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Mice; Mice, Knockout; Mitochondria; Neurodegenerative Diseases; Neurotoxins; Oxidative Stress; Oxygen; Seizures; Superoxide Dismutase; Superoxides | 2004 |
Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Celecoxib; Cell Survival; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Escape Reaction; Exploratory Behavior; Hippocampus; Kainic Acid; Male; Maze Learning; Motor Activity; Neurodegenerative Diseases; Neurons; Psychomotor Performance; Pyrazoles; Rats; Rats, Wistar; Reaction Time; Recovery of Function; Seizures; Sulfonamides; Time Factors | 2004 |
Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration.
Topics: Animals; Apoptosis; Astrocytes; Cell Line, Transformed; Cell Survival; Chemokine CCL2; Chemokine CXCL2; Culture Media, Conditioned; Disease Models, Animal; Encephalitis; Enzyme Inhibitors; Fibroblast Growth Factor 2; Hippocampus; Kainic Acid; Macrophages; Male; Monokines; Nerve Degeneration; Nerve Regeneration; Neurodegenerative Diseases; Neurons; Neurotoxins; Rats; Rats, Inbred F344; Up-Regulation | 2004 |
Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Astrocytes; Cell Count; Cell Death; Central Nervous System Diseases; Epilepsy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Growth Substances; Guanine; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Interleukins; Kainic Acid; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Neurofibrillary Tangles; Staining and Labeling; Tyrosine | 2005 |
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Calpain; Caspases; Cytoskeleton; Enzyme Activation; Hippocampus; Humans; Immunohistochemistry; Ischemia; Kainic Acid; Mice; Mice, Transgenic; Microscopy, Fluorescence; Models, Biological; Neurodegenerative Diseases; Neurons; Transgenes | 2005 |
Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice.
Topics: Animals; Animals, Newborn; Calcium; Calcium Signaling; Cells, Cultured; Female; Glutamic Acid; Kainic Acid; Longevity; Male; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mitochondrial Proteins; Neurodegenerative Diseases; Phenotype | 2007 |
Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice.
Topics: Analysis of Variance; Animals; Antigens, Differentiation; Blotting, Western; Cell Line; Cell Movement; Chemokine CCL2; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Fibrinolysin; Fibrinolytic Agents; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neurodegenerative Diseases; Time Factors; Transfection | 2007 |
TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice.
Topics: Animals; Behavior, Animal; Brain Injuries; Case-Control Studies; CD11b Antigen; Exploratory Behavior; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Motor Activity; Neurodegenerative Diseases; Receptors, Tumor Necrosis Factor, Type I; Seizures | 2008 |
Complement and glutamate neurotoxicity. Genotypic influences of C5 in a mouse model of hippocampal neurodegeneration.
Topics: Animals; Autoradiography; Calcium; Cell Survival; Complement C5; Excitatory Amino Acid Agonists; Genotype; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neurodegenerative Diseases; Receptors, AMPA | 1997 |
NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Central Nervous System Depressants; Corpus Striatum; Cysteine Proteinase Inhibitors; DNA Fragmentation; Ethanol; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Indans; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; NF-kappa B; Oligopeptides; Piperazines; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transcription Factor AP-1 | 2000 |
Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin.
Topics: Animals; Calbindin 2; Calbindins; Calcium-Binding Proteins; Carrier Proteins; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA Plasma Membrane Transport Proteins; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuropeptide Y; Organic Anion Transporters; Parvalbumins; Receptors, GABA-A; S100 Calcium Binding Protein G; Seizures; Somatostatin | 2000 |
Presence of apolipoprotein E immunoreactivity in degenerating neurones of mice is dependent on the severity of kainic acid-induced lesion.
Topics: Animals; Apolipoproteins E; Behavior, Animal; Brain; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurodegenerative Diseases; Neuroglia; Neurons; Neurotoxins; Seizures | 2000 |
Metyrapone, an inhibitor of corticosterone synthesis, blocks the kainic acid-induced expression of HSP 70.
Topics: Animals; Brain; Corticosterone; Excitatory Amino Acid Agonists; HSP70 Heat-Shock Proteins; Kainic Acid; Male; Metyrapone; Neurodegenerative Diseases; Rats; Rats, Wistar | 2000 |
Long-term increase of GluR2 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit in the dispersed dentate gyrus after intrahippocampal kainate injection in the mouse.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Time Factors | 2000 |
Increased expression of Fas (CD95/APO-1) in adult rat brain after kainate-induced seizures.
Topics: Animals; Brain; Cell Death; Excitatory Amino Acid Agonists; fas Receptor; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Tumor Suppressor Protein p53 | 2001 |
Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy.
Topics: Animals; Behavior, Animal; Cell Count; Cerebellar Diseases; Disease Models, Animal; Disease Progression; Glucose; Hippocampus; Immunohistochemistry; Injections, Subcutaneous; Insulin-Like Growth Factor I; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Olivary Nucleus; Physical Conditioning, Animal; Purkinje Cells; Pyridines; Rats; Rats, Wistar; Treatment Outcome | 2001 |
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.
Topics: Animals; Antioxidants; Cell Count; Cell Death; Cerebral Cortex; Disease Models, Animal; DNA-Binding Proteins; DNA, Mitochondrial; Electron Transport; High Mobility Group Proteins; Hippocampus; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Mice, Neurologic Mutants; Mitochondrial Myopathies; Mitochondrial Proteins; Neurodegenerative Diseases; Neurons; Nuclear Proteins; Organ Specificity; Oxidative Phosphorylation; Reactive Oxygen Species; RNA; RNA, Mitochondrial; Transcription Factors | 2001 |
Positive and negative modulation by AMPA- and kainate-receptors of striatal kainate injection-induced neuronal loss in rat forebrain.
Topics: Animals; Cell Death; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Neostriatum; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice.
Topics: Administration, Intranasal; Age Factors; Animals; Apoptosis; Behavior, Animal; Body Weight; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Isoenzymes; Kainic Acid; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Prostaglandin-Endoperoxide Synthases; Seizures; Survival Rate | 2002 |