Page last updated: 2024-08-21

kainic acid and Brain Ischemia

kainic acid has been researched along with Brain Ischemia in 103 studies

Research

Studies (103)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (5.83)	18.7374
1990's	45 (43.69)	18.2507
2000's	38 (36.89)	29.6817
2010's	13 (12.62)	24.3611
2020's	1 (0.97)	2.80

Authors

Authors	Studies
Gong, SJ; Hu, YY; Li, WB; Sun, YW; Xian, XH; Zhang, JG; Zhang, LY; Zhang, M	1
Alessandri, B; Frauenknecht, K; Heimann, A; Inui, T; Kempski, O; Nishimura, F; Sommer, C	1
Chin, K; Liu, F; Wang, M; Zhai, D	1
Bonova, P; Burda, J; Burda, R; Danielisova, V; Gottlieb, M; Matiasova, M; Morochovic, R; Nemethova, M	1
Li, Y; Sun, P; Wang, L; Zhang, S	1
Hu, YY; Li, L; Li, WB; Wang, D; Xu, J; Zhang, M	1
Cho, IH; Hong, J; Jo, EK; Karin, M; Kim, CH; Kim, DW; Kim, JH; Lee, H; Lee, JE; Lee, KE; Lee, S; Lee, SJ; Suh, EC	1
Clarke, PG; Rummel, C; Vaslin, A	1
Ander, BP; Jickling, G; Liu, DZ; Sharp, FR; Stamova, BS; Tian, Y; Turner, RJ; Xu, H; Zhan, X	1
Giorgi, FS; Hasson, H; Malhotra, S; Moshé, SL; Rosenbaum, DM	1
Iwata, Y; Jonas, RA; Nicole, O; Okamura, T; Zurakowski, D	1
Mishra, V; Raghubir, R; Sasmal, D; Verma, R	1
Li, C; Wu, YP; Yan, H; Zhang, GY; Zhang, J	1
de Almeida, LP; Duarte, CB; Gomes, JR; Inácio, AR; Iwata, N; Lobo, AC; Melo, CV; Saido, TC; Takano, J; Wieloch, T	1
Du, CP; Hou, XY; Xu, Y; Zhu, QJ	1
Cederroth, CR; Kruyer, A; Lowry, ER; Norris, EH; Strickland, S	1
Giffard, RG; Glassford, A; Lee, JE; Xu, L	1
Adams, DS; Boyer-Boiteau, A; Cornell-Bell, A; Fisher, M; Li, F; Shashoua, VE	1
Hashimoto, K; Nakamura, R; Suzuki, Y; Takagi, Y; Umemura, K	1
Chen, WY; Kuo, JS; Tsai, PJ; Yang, CS	1
Mahura, IS	1
Bartiromo, M; Bertolini, A; Ferrari, A; Genedani, S; Ottani, A; Renzo Botticelli, A; Saltini, S; Zaffe, D	1
Boche, D; Cunningham, C; Gauldie, J; Perry, VH	1
Arsenijevic, D; Clavel, S; de Bilbao, F; Giannakopoulos, P; Julien, P; Murthy, MR; Paradis, E; Richard, D; Vallet, P	1
Feustel, PJ; Jin, Y; Kimelberg, HK	1
Gary, D; Mackenzie, A; Mattson, M; Robertson, GS; Thompson, C	1
Bonhomme, N; Goldstein, S; Lestage, P; Lockhart, B; Roger, A	1
Giorgi, FS; Hasson, H; Malhotra, S; Moshé, SL; Rosenbaum, DM; Velísková, J	1
Ampo, K; Kadono, C; Kiryu-Seo, S; Kiyama, H; Konishi, H; Maeda, M; Ohba, N	1
Drago, F; Ignoto, A; Incognito, T; Micale, V; Rampello, L; Spartà, M	1
Anrather, J; Cho, S; Frys, KA; Iadecola, C; Kawano, T; Kunz, A; Orio, M; Park, L; Wang, G; Zhou, P	1
Avramescu, S; Ilie, A; Moldovan, M; Nita, DA; Spulber, S; Zagrean, AM; Zagrean, L	1
Caccia, C; Calabresi, M; Curatolo, L; Faravelli, L; Fariello, RG; Maestroni, S; Maj, R; Salvati, P	1
Geng, JX; Li, QJ; Li, SQ; Li, WB; Qi, J; Sun, XC; Xian, XH; Zhang, M	1
Gonzalez, SV; Hassel, B; Nguyen, NH	1
Koizumi, K; Lazar, J; Orman, R; Saito, T; Sakamoto, K; Salciccioli, L; Stewart, M	1
Brines, M; Cerami, A; Divoux, D; Ghezzi, P; Mengozzi, M; Petit, E; Probert, L; Quackenbush, J; Roberts, ML; Taoufik, E; Tseveleki, V; Valable, S	1
Kawai, N; Masuzawa, T; Nakaima, T; Oguro, K; Tsubokawa, H	1
Cai, Z; Hersey, K; Rhodes, PG; Sigrest, T	1
Albert, A; Bonhomme, V; Collette, J; Hans, P; Moonen, G	1
Gill, R	1
Kawai, N; Masuzawa, T; Oguro, K; Robinson, HP; Tsubokawa, H	1
Hirota, H; Kano, T; Katayama, Y; Kawamata, T; Tsubokawa, T	1
Kinney, HC; Panigrahy, A; Rava, LA; White, WF	1
Castellano, B; Diemer, NH; Finsen, BR; Jensen, MB; Jørgensen, MB; Zimmer, J	1
Yoneda, Y	1
Benicourt, C; Junien, JL; Lockhart, BP; Privat, A; Soulard, P	1
Johnston, MV; McDonald, JW	1
Aoki, H; Jian, Z; Kogure, K; Onodera, H; Yae, T	1
Butman, M; Chen, J; Graham, SH; Haglid, KG; Longo, FM; Sharp, FR; Wang, S	1
Ben-Ari, Y; Héron, A; Khrestchatisky, M; Moreau, J; Pollard, H	1
Diemer, NH; Finsen, BR; Jørgensen, MB; Zimmer, J	1
Heary, RF; Krieger, AJ; Maniker, AH; Sapru, HN	1
Furukawa, S	1
Cordi, AA; Desos, P; Lepagnol, JM; Lestage, P; Morain, P	1
Lei, DL; Liu, HM; Yang, DL	1
Bari, F; Busija, DW; Louis, TM	1
Estrada, A; Ferrer, I; Planas, AM; Sanz, O	1
Fónagy, A; Latzkovits, L; Torday, C	1
Althomsons, SP; Choi, DW; Goldberg, MP; Hyrc, KL; McDonald, JW	1
Bausch, SB; Catterall, WA; Franck, JE; Lin, RC; Noebels, JL; Westenbroek, RE	1
Almli, T; Chen, Q; Lukasiewicz, PD; Olney, JW; Romano, C	1
Durkin, JP; Mealing, GA; Morley, P; Murray, CL; Poulter, MO; Small, DL; Stanimirovic, DB	1
Bernardi, G; Calabresi, P; Centonze, D; Gubellini, P; Marfia, GA; Pisani, A; Sancesario, G	1
Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA	1
Chang, LK; Fink, SL; Ho, DY; Kunis, DM; Onley, D; Patel, MK; Sapolsky, RM; Steinberg, GK; Sun, GH; Yenari, MA	1
Bruce-Keller, AJ; Gary, DS; Kindy, MS; Mattson, MP	1
Feustel, PJ; Keller, RW; Kimelberg, HK; Seki, Y; Tranmer, BI	1
Ben-Ari, Y; Guischard, F; Khrestchatisky, M; Ouaghi, P; Rivera, S; Timsit, S; Tremblay, E	1
Housman, C; Mauger, D; Towfighi, J; Vannucci, RC	1
Que, M; Schiene, K; Witte, OW; Zilles, K	1
Iannotti, F; Pringle, AK; Signorelli, F; Thomas, SJ	1
Chen, Q; Hardy, K; Moulder, K; Olney, JW; Romano, C; Tenkova, T	1
Contestabile, A; Virgili, M	1
Ben-Ari, Y; Congar, P; Crépel, V; Gaïarsa, JL; Popovici, T	1
Blondeau, N; Heurteaux, C; Lauritzen, I; Lazdunski, M; Romey, G; Widmann, C	1
Dawson, LA; Djali, S; Gonzales, C; Vinegra, MA; Zaleska, MM	1
O'Neill, MJ	1
Camandola, S; Chan, SL; Culmsee, C; Greig, NH; Guo, Z; Mattson, MP; Yu, QS; Zhu, X	1
Bonhomme, N; Casara, P; Dorey, G; Lestage, P; Lockhart, B; Roger, A	1
Akaike, A; Ishida, Y; Kakimura, J; Kitamura, Y; Mizutani, H; Shimohama, S; Takata, K; Taniguchi, T	1
Bienemann, A; Henley, JM; Ma, J; Noel, J; Ralph, GS; Tan, HK; Uney, JB	1
Brines, ML; Cerami, A; Cerami, CJ; Ghezzi, P	1
Blondeau, N; Heurteaux, C; Lazdunski, M; Widmann, C	1
Chang, SY; Choi, JS; Chung, JM; Gwag, BJ; Joo, CK; Oh, S; Ryoo, IJ; Seo, SY; Yoo, ID; Yun, BS	1
Iadecola, C; Kazama, K; Niwa, K; Ross, ME; Sugimoto, K	1
Brines, M; Cerami, A; Cerami, C; Ghezzi, P; Itri, LM	1
Jiang, XF; Kamichi, S; Maeno, H; Nagata, I; Namura, S; Takami, S; Wada, K	1
Borgers, M; Van Deuren, B; Van Reempts, J	1
Diemer, NH; Johansen, FF; Jørgensen, MB	1
Kirino, T; Sano, K	1
Diemer, NH; Jensen, CV; Jørgensen, MB	1
Birch, PJ; Hayes, AG; Rogers, H	1
Brown, IR	1
Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ	1
Benavides, J; Capdeville, C; Dauphin, F; Dubois, A; Duverger, D; Fage, D; Gotti, B; MacKenzie, ET; Scatton, B	1
Franck, JE; Roberts, DL	1
Beaudoin, M; Ben-Ari, Y; Crepel, V; Represa, A	1
Benveniste, H; Christensen, T; Diemer, NH; Hagberg, H; Jørgensen, MB; Sandberg, M	1
Bénavidès, J; Dubois, A; Duverger, D; Fage, D; Gotti, B; MacKenzie, ET; Peny, B; Scatton, B	1
Ben-Ari, Y; Crepel, V; Represa, A	1
Kogure, K; Onodera, H; Sato, G	1
Korf, J; Postema, F	1

Reviews

10 review(s) available for kainic acid and Brain Ischemia

Article	Year
[Cerebral ischemia-hypoxia and biophysical mechanisms of neurodegeneration and neuroprotection effects]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2003, Volume: 49, Issue:2 Topics: Animals; Brain Ischemia; Calcium; Calcium Channels; Excitatory Amino Acid Antagonists; Humans; Hypoxia, Brain; Ion Channels; Kainic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxygen; Reactive Oxygen Species; Receptors, Glutamate; Reperfusion Injury; Sodium; Sodium Channel Blockers; Sodium Channels	2003
Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology, 2006, Oct-10, Volume: 67, Issue:7 Suppl 2 Topics: Alanine; Animals; Antiparkinson Agents; Benzylamines; Brain Ischemia; Disease Models, Animal; Gerbillinae; Humans; Kainic Acid; Levodopa; Mice; MPTP Poisoning; Neurons; Rats; Veratridine	2006
The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia. Cerebrovascular and brain metabolism reviews, 1994,Fall, Volume: 6, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Humans; Kainic Acid	1994
[Receptive mechanisms of excitatory amino acid signals]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1993, Volume: 113, Issue:7 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Epilepsy; Ibotenic Acid; Kainic Acid; Ligands; N-Methylaspartate; Receptors, Amino Acid; Signal Transduction; Transcription Factors	1993
Excitatory amino acid neurotoxicity in the developing brain. NIDA research monograph, 1993, Volume: 133 Topics: Animals; Brain; Brain Ischemia; Dizocilpine Maleate; Humans; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate	1993
[Expression of neurotrophin proteins in the brain, and its physiological significance]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1995, Volume: 15, Issue:5 Topics: Animals; Brain; Brain Ischemia; Cell Death; Humans; Kainic Acid; Nerve Growth Factors; Neurons	1995
Effects of epoetin alfa on the central nervous system. Seminars in oncology, 2001, Volume: 28, Issue:2 Suppl 8 Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Central Nervous System; Encephalomyelitis; Epoetin Alfa; Erythropoietin; Humans; Kainic Acid; Mice; Models, Animal; Neuroprotective Agents; Receptors, Erythropoietin; Recombinant Proteins; Seizures	2001
Neuroprotective properties of epoetin alfa. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17 Suppl 1 Topics: Acute Disease; Animals; Autoimmune Diseases; Brain; Brain Ischemia; Cerebral Cortex; Encephalitis; Epoetin Alfa; Erythropoietin; Humans; Kainic Acid; Neuroprotective Agents; Recombinant Proteins; Stroke; Wounds, Nonpenetrating	2002
Ammon's horn sclerosis: its pathogenesis and clinical significance. The Tohoku journal of experimental medicine, 1990, Volume: 161 Suppl Topics: Animals; Brain Ischemia; Cell Survival; Epilepsy, Temporal Lobe; Gerbillinae; Glutamates; Glutamic Acid; Hippocampus; Humans; Hypoxia; Kainic Acid; Models, Neurological; Neurons; Sclerosis; Status Epilepticus; Synaptic Transmission; Temporal Lobe; Terminology as Topic	1990
Induction of heat shock (stress) genes in the mammalian brain by hyperthermia and other traumatic events: a current perspective. Journal of neuroscience research, 1990, Volume: 27, Issue:3 Topics: Animals; Brain Chemistry; Brain Injuries; Brain Ischemia; Fever; Gene Expression Regulation; Heat-Shock Proteins; Humans; Infections; Kainic Acid; Mammals; Multigene Family; Nerve Tissue Proteins; Rabbits; Rats; Seizures	1990

Other Studies

93 other study(ies) available for kainic acid and Brain Ischemia

Article	Year
The p38 MAPK/NF-κB pathway mediates GLT-1 up-regulation during cerebral ischemic preconditioning-induced brain ischemic tolerance in rats. Brain research bulletin, 2021, Volume: 175 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Excitatory Amino Acid Transporter 2; Imidazoles; Ischemic Preconditioning; Kainic Acid; Male; MAP Kinase Signaling System; Neuroprotection; NF-kappa B; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Sulfones; Transcription Factor RelA	2021
Neuroprotective effect of ceftriaxone on the penumbra in a rat venous ischemia model. Neuroscience, 2013, Jul-09, Volume: 242 Topics: Animals; Anti-Bacterial Agents; Brain Ischemia; Ceftriaxone; Cerebral Infarction; Cortical Spreading Depression; Drug Interactions; Excitatory Amino Acid Transporter 2; Kainic Acid; Male; Neuroprotective Agents; Potassium Chloride; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate	2013
Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage. Molecular brain, 2014, Mar-27, Volume: 7 Topics: Animals; Brain Ischemia; Cell Death; Cell Nucleus; Cytoprotection; Disease Models, Animal; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; HEK293 Cells; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Neurons; Neuroprotective Agents; Nuclear Proteins; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Fusion Proteins; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases	2014
Delayed remote ischemic postconditioning protects against transient cerebral ischemia/reperfusion as well as kainate-induced injury in rats. Acta histochemica, 2014, Volume: 116, Issue:6 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Female; Ischemic Postconditioning; Kainic Acid; Male; Maze Learning; Memory Disorders; Rats, Wistar; Reperfusion Injury	2014
Harmine mediated neuroprotection via evaluation of glutamate transporter 1 in a rat model of global cerebral ischemia. Neuroscience letters, 2014, Nov-07, Volume: 583 Topics: Animals; Astrocytes; Brain Infarction; Brain Ischemia; Cell Survival; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Female; Harmine; Injections, Intraperitoneal; Kainic Acid; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; RNA, Messenger	2014
Ceftriaxone modulates uptake activity of glial glutamate transporter-1 against global brain ischemia in rats. Journal of neurochemistry, 2015, Volume: 132, Issue:2 Topics: Animals; Biological Transport; Brain Ischemia; CA1 Region, Hippocampal; Ceftriaxone; Drug Evaluation, Preclinical; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Kainic Acid; Male; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Pyramidal Cells; Random Allocation; Rats; Rats, Wistar; Up-Regulation	2015
Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain : a journal of neurology, 2008, Volume: 131, Issue:Pt 11 Topics: Animals; Brain Ischemia; Cell Death; Cells, Cultured; Gene Deletion; Gene Expression Regulation; Hippocampus; I-kappa B Kinase; Inflammation Mediators; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Knockout; Microglia; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha	2008
Unconjugated TAT carrier peptide protects against excitotoxicity. Neurotoxicity research, 2009, Volume: 15, Issue:2 Topics: Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; tat Gene Products, Human Immunodeficiency Virus; Time Factors	2009
Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:1 Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebral Hemorrhage; Excitatory Amino Acid Antagonists; Kainic Acid; Male; MicroRNAs; Rats; Rats, Sprague-Dawley; Seizures; Stroke; Up-Regulation	2010
Harmful effect of kainic acid on brain ischemic damage is not related to duration of status epilepticus. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2010, Volume: 31, Issue:1 Topics: Animals; Anticonvulsants; Brain; Brain Ischemia; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Time Factors	2010
Ibuprofen for neuroprotection after cerebral ischemia. The Journal of thoracic and cardiovascular surgery, 2010, Volume: 139, Issue:2 Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Ibuprofen; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Neuroprotective Agents	2010
Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury. European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3 Topics: Animals; Brain; Brain Ischemia; Ceftriaxone; Cerebral Infarction; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Neuroglia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation	2010
Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment. The Journal of biological chemistry, 2011, Mar-04, Volume: 286, Issue:9 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Caspase 3; Cell Line, Tumor; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Humans; Kainic Acid; Male; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Ubiquitin	2011
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Mar-23, Volume: 31, Issue:12 Topics: Animals; Blotting, Western; Brain Ischemia; Calpain; DNA; Excitatory Amino Acid Agonists; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Infarction, Middle Cerebral Artery; Kainic Acid; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Neurotoxins; PC12 Cells; Phosphoric Monoester Hydrolases; Plasmids; Pregnancy; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Status Epilepticus; Synapses; Synaptic Transmission; Transfection; Vesicular Glutamate Transport Proteins	2011
SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation. FEBS letters, 2012, May-07, Volume: 586, Issue:9 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Activation; GluK2 Kainate Receptor; Humans; Kainic Acid; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase Kinase Kinase 11; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Sumoylation	2012
The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration. Neuroscience, 2013, Apr-03, Volume: 235 Topics: Affect; Animals; Blotting, Western; Brain Ischemia; CA3 Region, Hippocampal; Cell Death; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Agonists; Hippocampus; Hypoxia, Brain; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Maze Learning; Memory; Mice; Mice, Knockout; Microinjections; Motor Activity; Neurodegenerative Diseases; Neurons; Receptors, Kainic Acid; Reflex, Startle; Stereotaxic Techniques; Stroke	2013
Caspase inhibitors reduce the apoptotic but not necrotic component of kainate injury in primary murine cortical neuronal cultures. Neurological research, 2002, Volume: 24, Issue:8 Topics: Animals; Apoptosis; Brain Ischemia; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetus; Kainic Acid; Mice; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins	2002
Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia. Brain research, 2003, Feb-14, Volume: 963, Issue:1-2 Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Calmodulin; Cells, Cultured; Cerebrovascular Circulation; Glutamic Acid; In Vitro Techniques; Injections, Intravenous; Kainic Acid; Male; Middle Cerebral Artery; Nerve Tissue Proteins; Neuroprotective Agents; Peptide Fragments; Rats; Stroke; Transcription Factor AP-1	2003
Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats. Brain research, 2003, Feb-21, Volume: 964, Issue:1 Topics: Aging; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Telencephalon	2003
Ionotropic glutamate receptors are involved in malondialdehyde production in anesthetized rat brain cortex: a microdialysis study. Redox report : communications in free radical research, 2003, Volume: 8, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Brain; Brain Ischemia; Cerebral Cortex; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Excitatory Amino Acid Agonists; HeLa Cells; Humans; Kainic Acid; Malondialdehyde; Perfusion; Pyrrolidines; Rats; Receptors, Glutamate; Time Factors	2003
Effect of gamma-hydroxybutyrate in two rat models of focal cerebral damage. Brain research, 2003, Oct-03, Volume: 986, Issue:1-2 Topics: Animals; Apomorphine; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Kainic Acid; Learning; Male; Memory Disorders; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Sodium Oxybate	2003
Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:10 Topics: Adenoviridae; Animals; Brain Ischemia; Cytokines; Excitatory Amino Acid Agonists; Female; Gene Expression; Gene Transfer Techniques; Ischemic Preconditioning; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Neurotoxins; Transforming Growth Factor beta; Transforming Growth Factor beta1	2003
Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia. Neurobiology of disease, 2004, Volume: 15, Issue:2 Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hippocampus; Infarction, Middle Cerebral Artery; Kainic Acid; Lipase; Lipoprotein Lipase; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Reaction Time; RNA, Messenger; Up-Regulation	2004
Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra. Stroke, 2004, Volume: 35, Issue:5 Topics: Amino Acid Transport System X-AG; Animals; Anion Transport Proteins; Aspartic Acid; Astrocytes; Brain Ischemia; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Microdialysis; Neurons; Rats; Receptors, Glutamate; Tamoxifen; Taurine	2004
Kainic acid-induced naip expression in the hippocampus is blocked in mice lacking TNF receptors. Brain research. Molecular brain research, 2004, Apr-07, Volume: 123, Issue:1-2 Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Nerve Degeneration; Nerve Tissue Proteins; Neuronal Apoptosis-Inhibitory Protein; Neuroprotective Agents; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tumor Necrosis Factor-alpha	2004
In vivo neuroprotective effects of the novel imidazolyl nitrone free-radical scavenger (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176). European journal of pharmacology, 2005, Mar-28, Volume: 511, Issue:2-3 Topics: Animals; Brain Ischemia; Cell Survival; Corpus Striatum; Dopamine; Free Radical Scavengers; Hippocampus; Imidazoles; Kainic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Nitrogen Oxides; Quinoxalines; Rats; Rats, Wistar	2005
Effects of status epilepticus early in life on susceptibility to ischemic injury in adulthood. Epilepsia, 2005, Volume: 46, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Disease Susceptibility; Electroencephalography; Flurothyl; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Monitoring, Physiologic; Neocortex; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stroke	2005
The p53-independent nuclear translocation of cyclin G1 in degenerating neurons by ischemic and traumatic insults. Experimental neurology, 2005, Volume: 193, Issue:2 Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Cells, Cultured; Cyclin G; Cyclin G1; Cyclins; Cycloheximide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Gerbillinae; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Knockout; Microscopy, Immunoelectron; N-Methylaspartate; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Time Factors; Tumor Suppressor Protein p53	2005
Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:3 Topics: Amnesia; Animals; Antioxidants; Behavior, Animal; Brain Diseases; Brain Ischemia; Dopamine Agents; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Glutathione; Hypoxia, Brain; Injections, Intraventricular; Injections, Subcutaneous; Kainic Acid; Male; Motor Activity; Oxidation-Reduction; Rats; Rats, Sprague-Dawley	2006
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nature medicine, 2006, Volume: 12, Issue:2 Topics: Animals; Brain; Brain Ischemia; Calcium; Cell Death; Cyclooxygenase 2; Dinoprostone; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype	2006
Delayed ischemic electrocortical suppression during rapid repeated cerebral ischemia and kainate-induced seizures in rat. The European journal of neuroscience, 2006, Volume: 23, Issue:8 Topics: Animals; Brain Ischemia; Cerebral Cortex; Electrodes; Electroencephalography; Evoked Potentials, Visual; Kainic Acid; Male; Rats; Rats, Wistar; Reperfusion; Seizures; Time Factors	2006
The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007, Volume: 27, Issue:7 Topics: Animals; Astrocytes; Blotting, Western; Brain Ischemia; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Ischemic Preconditioning; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Up-Regulation	2007
Formation of glycerol from glucose in rat brain and cultured brain cells. Augmentation with kainate or ischemia. Journal of neurochemistry, 2007, Volume: 101, Issue:6 Topics: Animals; Astrocytes; Brain; Brain Ischemia; Carbon Isotopes; Cells, Cultured; Cerebellum; Glucose; Glycerol; Glycerophosphates; Kainic Acid; Male; Metabolic Networks and Pathways; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Rats; Rats, Wistar	2007
Autonomic consequences of kainic acid-induced limbic cortical seizures in rats: peripheral autonomic nerve activity, acute cardiovascular changes, and death. Epilepsia, 2008, Volume: 49, Issue:6 Topics: Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Brain Ischemia; Cardiac Output, Low; Cerebral Cortex; Echocardiography; Electrocardiography; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Heart; Heart Rate; Hypothalamus; Kainic Acid; Limbic System; Male; Medulla Oblongata; Nitroprusside; Peripheral Nerves; Phenylephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System	2008
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury. Proceedings of the National Academy of Sciences of the United States of America, 2008, Apr-22, Volume: 105, Issue:16 Topics: Animals; Brain Ischemia; Cell Death; Cytoprotection; Erythropoietin; Excitatory Amino Acid Agonists; Gene Expression Profiling; Kainic Acid; Male; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Oligonucleotide Array Sequence Analysis; Receptors, Erythropoietin; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A	2008
Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia. Journal of neurophysiology, 1995, Volume: 74, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Electrophysiology; Excitatory Amino Acid Agonists; Gerbillinae; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Neurons; Neurotoxins; Patch-Clamp Techniques; Spider Venoms; Synapses	1995
Intrauterine hypoxia-ischemia increases N-methyl-D-aspartate-induced cGMP formation and glutamate accumulation in cultured rat cerebellar granule cells. Pediatric research, 1995, Volume: 38, Issue:1 Topics: Animals; Arginine; Brain Ischemia; Cells, Cultured; Cerebellar Diseases; Chronic Disease; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetal Hypoxia; Gestational Age; Glutamic Acid; Hypoxia, Brain; Kainic Acid; N-Methylaspartate; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley	1995
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity. Journal of neurosurgical anesthesiology, 1994, Volume: 6, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurons; Phosphopyruvate Hydratase; Propofol; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors	1994
Single glutamate channels in CA1 pyramidal neurones after transient ischaemia. Neuroreport, 1995, Feb-15, Volume: 6, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Gerbillinae; Kainic Acid; N-Methylaspartate; Patch-Clamp Techniques; Pyramidal Cells; Receptors, Glutamate; Time Factors	1995
Inhibition of the high-affinity glutamate uptake system facilitates the massive potassium flux during cerebral ischaemia in vivo. Neurological research, 1995, Volume: 17, Issue:2 Topics: Animals; Brain Ischemia; Female; Glutamic Acid; Ion Channel Gating; Kainic Acid; Microdialysis; Potassium; Rats; Rats, Sprague-Dawley	1995
Developmental changes in [3H]kainate binding in human brainstem sites vulnerable to perinatal hypoxia-ischemia. Neuroscience, 1995, Volume: 67, Issue:2 Topics: Aged; Autoradiography; Brain Ischemia; Brain Stem; Child, Preschool; Female; Gestational Age; Humans; Hypoxia, Brain; Kainic Acid; Middle Aged; Pregnancy; Receptors, Kainic Acid	1995
Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus. Experimental neurology, 1993, Volume: 120, Issue:1 Topics: Acid Anhydride Hydrolases; Animals; Astrocytes; Brain Diseases; Brain Ischemia; Hippocampus; Immunoglobulin G; Immunohistochemistry; Intermediate Filament Proteins; Kainic Acid; Macrophage-1 Antigen; Male; Neuroglia; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Staining and Labeling	1993
Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies. Brain research, 1995, Mar-27, Volume: 675, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzofurans; Brain Ischemia; Cell Death; Cells, Cultured; Dizocilpine Maleate; Hypoxia; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma	1995
Neural grafting to ischemic CA1 lesions in the rat hippocampus: an autoradiographic study. Neuroscience, 1993, Volume: 56, Issue:2 Topics: Acetylcholinesterase; Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Fetal Tissue Transplantation; Hippocampus; Kainic Acid; Ligands; Male; Muscimol; Naloxone; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Puromycin; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Neurotransmitter; Spiperone; Stereotaxic Techniques; Up-Regulation	1993
Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia. Neurochemistry international, 1993, Volume: 23, Issue:6 Topics: Animals; Base Sequence; Brain; Brain Ischemia; Carrier Proteins; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Kainic Acid; Male; Molecular Chaperones; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Time Factors	1993
Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia. Neuroscience, 1993, Volume: 57, Issue:3 Topics: Animals; Base Sequence; Brain Ischemia; Disease Susceptibility; Epilepsy; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; Neurons; Oligonucleotide Probes; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Tissue Distribution	1993
Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus. Glia, 1993, Volume: 7, Issue:1 Topics: Animals; Brain Diseases; Brain Ischemia; Hippocampus; Histocompatibility Antigens; Kainic Acid; Leukocyte Common Antigens; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Wistar	1993
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area. Journal of neurosurgery, 1993, Volume: 78, Issue:6 Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pressure; Brain Ischemia; Dose-Response Relationship, Drug; Glutamates; Heart Rate; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Muscimol; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Vasopressin; Vasopressins	1993
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties. Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gerbillinae; Kainic Acid; Mice; Molecular Structure; N-Methylaspartate; Neuroprotective Agents; Organophosphonates; Quinolones; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Xenopus	1996
Kainate-induced brain lesion: similar local and remote histopathological and molecular changes as in ischemic brain infarct. Journal of neuropathology and experimental neurology, 1996, Volume: 55, Issue:7 Topics: Animals; Brain; Brain Diseases; Brain Ischemia; Cerebral Infarction; Kainic Acid; Male; Microinjections; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Staining and Labeling; Time Factors	1996
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets. Stroke, 1997, Volume: 28, Issue:6 Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Indomethacin; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Reperfusion Injury; Swine; Theophylline; Vasodilator Agents	1997
Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience, 1997, Volume: 80, Issue:1 Topics: Animals; Brain; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; HSP70 Heat-Shock Proteins; Immunohistochemistry; Isoenzymes; Kainic Acid; Male; Peroxidases; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley	1997
Intracellular free Ca2+ elevations in cultured astroglia induced by neuroligands playing a role in cerebral ischemia. Acta chirurgica Hungarica, 1997, Volume: 36, Issue:1-4 Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Calcium; Cells, Cultured; Cytoplasm; Excitatory Amino Acid Agonists; Extracellular Space; Fluorescent Dyes; Fura-2; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Quisqualic Acid; Rats; Receptors, Glutamate; Serotonin; Spectrometry, Fluorescence; Vasoconstrictor Agents; Vasopressins	1997
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nature medicine, 1998, Volume: 4, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Brain Ischemia; Cell Death; Cells, Cultured; Glutamic Acid; Growth Substances; Hypoxia; Kainic Acid; Male; Mice; Microinjections; Oligodendroglia; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Signal Transduction; Time Factors	1998
Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Apr-01, Volume: 18, Issue:7 Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Astrocytes; Brain Injuries; Brain Ischemia; Calcium Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gerbillinae; Glial Fibrillary Acidic Protein; Gliosis; Homeostasis; Hot Temperature; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Neurologic Mutants; Myelin Sheath; Rats; Up-Regulation; Wounds, Stab	1998
Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina. Neuroscience letters, 1998, Feb-20, Volume: 242, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flufenamic Acid; Glucose; Kainic Acid; Meclofenamic Acid; Mefenamic Acid; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; ortho-Aminobenzoates; Oxygen; Patch-Clamp Techniques; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells	1998
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillaries; Cattle; Cells, Cultured; Cerebrovascular Circulation; Colforsin; Cyclic AMP; Cycloleucine; Endothelin-1; Endothelium, Vascular; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate; Kainic Acid; Mice; N-Methylaspartate; Neurons; Polymerase Chain Reaction; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Second Messenger Systems	1998
Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease. Annals of neurology, 1998, Volume: 43, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Corpus Striatum; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Huntington Disease; Interneurons; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	1998
Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones. Free radical research, 1998, Volume: 28, Issue:2 Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cerebellar Cortex; Dithiothreitol; Egtazic Acid; Glutamic Acid; Ion Transport; Kainic Acid; Membrane Proteins; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Sodium; Sulfhydryl Compounds; Superoxides; Tetrodotoxin	1998
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Annals of neurology, 1998, Volume: 44, Issue:4 Topics: Animals; beta-Galactosidase; Brain Ischemia; Cell Survival; Cerebrovascular Disorders; Epilepsy; Genetic Therapy; Genetic Vectors; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Reference Values; Simplexvirus; Time Factors	1998
Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:12 Topics: Animals; Antigens, CD; Brain; Brain Ischemia; Cerebral Infarction; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reperfusion Injury	1998
Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker. Stroke, 1999, Volume: 30, Issue:2 Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Therapy, Combination; Glutamic Acid; Ion Pumps; Kainic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Stilbenes	1999
Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death? The European journal of neuroscience, 1999, Volume: 11, Issue:1 Topics: Amygdala; Animals; Apoptosis; Biomarkers; Brain Ischemia; Cell Cycle; Cell Nucleus; Cyclin D1; Cyclin D2; Cyclin D3; Cyclins; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxins; Prosencephalon; Rats; Rats, Wistar; RNA, Messenger; Time Factors	1999
Effect of seizures on cerebral hypoxic-ischemic lesions in immature rats. Brain research. Developmental brain research, 1999, Mar-12, Volume: 113, Issue:1-2 Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Ischemia; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Female; Flurothyl; Hippocampus; Hypoxia, Brain; Kainic Acid; Pregnancy; Rats; Rats, Wistar	1999
Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain. Neuroscience letters, 1999, Oct-01, Volume: 273, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Intracranial Thrombosis; Kainic Acid; Light; Male; Radiation Injuries, Experimental; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors; Up-Regulation	1999
Ischaemic pre-conditioning in organotypic hippocampal slice cultures is inversely correlated to the induction of the 72 kDa heat shock protein (HSP72). Brain research, 1999, Oct-23, Volume: 845, Issue:2 Topics: Animals; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamic Acid; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Ischemic Preconditioning; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1999
Excitotoxic cell death dependent on inhibitory receptor activation. Experimental neurology, 1999, Volume: 160, Issue:1 Topics: Action Potentials; Animals; Bicuculline; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cerebellar Cortex; Chick Embryo; Chloride Channels; Chlorides; Excitatory Amino Acid Agonists; GABA Antagonists; Glycine; Ion Channel Gating; Ion Transport; Kainic Acid; Neuroprotective Agents; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glycine; Retina; Strychnine	1999
Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats. Neuroscience letters, 2000, Mar-10, Volume: 281, Issue:2-3 Topics: Animals; Antioxidants; Brain; Brain Ischemia; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neuroprotective Agents; Olfactory Pathways; Rats; Rats, Wistar; Resveratrol; Stilbenes; Wine	2000
Permanent reduction of seizure threshold in post-ischemic CA3 pyramidal neurons. Journal of neurophysiology, 2000, Volume: 83, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Patch-Clamp Techniques; Periodicity; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Stimulation, Chemical; Synapses; Time Factors	2000
Polyunsaturated fatty acids are potent neuroprotectors. The EMBO journal, 2000, Apr-17, Volume: 19, Issue:8 Topics: alpha-Linolenic Acid; Animals; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Fatty Acids, Unsaturated; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Magnesium; Mice; Mice, Inbred BALB C; Neurons; Palmitic Acid; Potassium Channels; Seizures; Synapsins; Time Factors	2000
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats. Brain research bulletin, 2000, Volume: 53, Issue:6 Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Rats; Rats, Inbred SHR; Reperfusion Injury; Tetrodotoxin; Time Factors	2000
Pharmacology and neuroprotective actions of mGlu receptor ligands. Developmental medicine and child neurology. Supplement, 2001, Volume: 86 Topics: Amino Acids; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Glycine; Hippocampus; Humans; Kainic Acid; Ligands; Nerve Degeneration; Neuroprotective Agents; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate	2001
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. Journal of neurochemistry, 2001, Volume: 77, Issue:1 Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53	2001
Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2-dihydroquinoline (S 33113) in models of cerebral neurodegeneration. European journal of pharmacology, 2001, Mar-23, Volume: 416, Issue:1-2 Topics: Alloxan; Animals; Antioxidants; Body Temperature; Brain Ischemia; Cell Survival; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Hyperglycemia; Injections, Intraventricular; Kainic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Nerve Degeneration; Neurons; Quinolines; Rats; Rats, Wistar; Rectum; Survival Rate; tert-Butylhydroperoxide	2001
Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain research, 2001, Apr-13, Volume: 898, Issue:1 Topics: alpha-Synuclein; Animals; Brain; Brain Ischemia; Cell Death; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Rats; Rats, Wistar; Synucleins; Time Factors	2001
Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress. Molecular and cellular neurosciences, 2001, Volume: 17, Issue:4 Topics: Animals; Brain Ischemia; Calcium; Carrier Proteins; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Gene Expression; Glucose; Hippocampus; Kainic Acid; N-Ethylmaleimide-Sensitive Proteins; Nerve Degeneration; Neurons; Receptors, AMPA; Recombinant Proteins; Transfection; Vesicular Transport Proteins	2001
Activation of the nuclear factor-kappaB is a key event in brain tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jul-01, Volume: 21, Issue:13 Topics: Active Transport, Cell Nucleus; alpha-Linolenic Acid; Animals; Blotting, Western; Brain; Brain Ischemia; Ditiocarb; DNA; DNA-Binding Proteins; Epilepsy; Hippocampus; I-kappa B Proteins; Immunohistochemistry; Ischemic Preconditioning; Kainic Acid; Male; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Subunits; Rats; Rats, Wistar; Signal Transduction	2001
Complestatin is a noncompetitive peptide antagonist of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors: secure blockade of ischemic neuronal death. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:1 Topics: Animals; Apoptosis; Brain Ischemia; Calcium; Cell Death; Chlorophenols; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Oligopeptides; Oxidative Stress; Oxygen; Patch-Clamp Techniques; Peptides, Cyclic; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retinal Vessels	2001
Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:12 Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclooxygenase 1; Disease Susceptibility; Excitatory Amino Acid Agonists; Female; Infarction, Middle Cerebral Artery; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurotoxins; Parietal Lobe; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Stroke	2001
Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice. Neuroscience letters, 2002, May-17, Volume: 324, Issue:2 Topics: Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acid Transporter 2; Extracellular Space; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Neurotoxins; Neurotransmitter Uptake Inhibitors; Reperfusion Injury; Water-Electrolyte Balance	2002
Microwave-enhanced silver staining of degenerating neuronal processes. Acta neuropathologica, 1992, Volume: 84, Issue:2 Topics: Animals; Animals, Newborn; Axons; Brain; Brain Ischemia; Histocytochemistry; Kainic Acid; Microscopy, Electron; Microwaves; Nerve Degeneration; Nerve Endings; Neurons; Rats; Silver Staining	1992
Post-ischemic and kainic acid-induced c-fos protein expression in the rat hippocampus. Acta neurologica Scandinavica, 1991, Volume: 84, Issue:4 Topics: Animals; Brain Ischemia; Gene Expression Regulation; Hippocampus; Immunoenzyme Techniques; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; RNA, Messenger	1991
Modification of [3H]inositoltrisphosphate binding in kainic acid-lesioned and postischemic rat hippocampus. Brain research, 1991, Jan-11, Volume: 538, Issue:2 Topics: Animals; Autoradiography; Brain Ischemia; Calcium; Hippocampus; Inosine Triphosphate; Kainic Acid; Male; Pyramidal Tracts; Rats; Rats, Inbred Strains	1991
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro. Naunyn-Schmiedeberg's archives of pharmacology, 1990, Volume: 342, Issue:5 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Hypoglycemia; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate	1990
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science (New York, N.Y.), 1990, Feb-02, Volume: 247, Issue:4942 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter	1990
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration. Brain research, 1990, Jul-09, Volume: 522, Issue:2 Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Isoquinolines; Kainic Acid; Male; Mice; Nerve Degeneration; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A	1990
Combined kainate and ischemia produces 'mesial temporal sclerosis'. Neuroscience letters, 1990, Oct-16, Volume: 118, Issue:2 Topics: Animals; Brain Ischemia; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Sclerosis; Temporal Lobe	1990
Hippocampal damage induced by ischemia and intra-amygdaloid kainate injection: effect on N-methyl-D-aspartate, N-(1-[2-thienyl]cyclohexyl)piperidine and glycine binding sites. Neuroscience, 1989, Volume: 31, Issue:3 Topics: Amygdala; Animals; Brain Ischemia; Hippocampus; Kainic Acid; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine	1989
Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1989, Volume: 9, Issue:5 Topics: Amino Acids; Animals; Brain; Brain Ischemia; Cell Survival; Dialysis; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neural Pathways; Osmolar Concentration; Rats; Rats, Inbred Strains	1989
Imaging of primary and remote ischaemic and excitotoxic brain lesions. An autoradiographic study of peripheral type benzodiazepine binding sites in the rat and cat. Brain research, 1988, Mar-29, Volume: 445, Issue:1 Topics: Animals; Autoradiography; Benzazepines; Brain; Brain Ischemia; Cerebral Arteries; Dopamine Antagonists; Isoquinolines; Kainic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, GABA-A; Tritium	1988
Effect of ischemia and intra-amygdaloid kainate injection on the density of NMDA binding sites in the hippocampal CA1 region. European journal of pharmacology, 1988, Jul-07, Volume: 151, Issue:2 Topics: Amygdala; Animals; Brain Ischemia; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1988
Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells. Neuroscience letters, 1986, Jul-24, Volume: 68, Issue:2 Topics: Animals; Binding Sites; Brain Ischemia; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neural Pathways; Rats; Rats, Inbred Strains	1986
Rapid shrinkage of rat striatal extracellular space after local kainate application and ischemia as recorded by impedance. Journal of neuroscience research, 1988, Volume: 19, Issue:4 Topics: Animals; Brain Ischemia; Corpus Striatum; Electric Stimulation; Extracellular Space; Female; Kainic Acid; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Tetrodotoxin	1988