kainic acid has been researched along with Benign Psychomotor Epilepsy, Childhood in 446 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (2.91) | 18.7374 |
1990's | 61 (13.68) | 18.2507 |
2000's | 112 (25.11) | 29.6817 |
2010's | 182 (40.81) | 24.3611 |
2020's | 78 (17.49) | 2.80 |
Authors | Studies |
---|---|
Braine, EL; Casillas-Espinosa, PM; Curl, CL; Delbridge, LM; Gomes, FM; Jones, NC; Liu, Z; Macefield, VG; O'Brien, TJ; Powell, KL; Raaijmakers, AJA; Sharma, P; Sivathamboo, S | 1 |
Chen, Y; Liu, Q; Liu, Y; Tan, C; Wang, Y; Xu, T; Yang, J; Zhang, P | 1 |
Drysdale, ND; Matthews, E; McNamara, JO; Pan, E; Schuetz, E | 1 |
Adeyemi, OO; Afolayan, O; Ben-Azu, B; Ishola, IO; James, AB; Ojo, ES | 1 |
Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS | 1 |
Li, L; Liu, X; Ma, L; Wang, L; Wang, T | 1 |
Lisgaras, CP; Scharfman, HE | 1 |
Fernandez, AM; Grogan, DP; Gross, RE; Gutekunst, CA; Pedersen, NP | 1 |
Liu, SY; Shen, KF; Wang, J; Wang, ZK; Wu, KF; Wu, ZF; Yang, H; Yang, XL; Yue, J; Zhang, CQ; Zhu, G | 1 |
Audinat, E; Blaquiere, M; Canet, G; deBock, F; Desrumaux, C; Garcia, V; Givalois, L; Hernandez, C; Marchi, N; Moreno-Montano, M; Planel, E; Vitalis, M; Zub, E; Zussy, C | 1 |
Haftcheshmeh, SM; Khamse, S; Momtazi-Borojeni, AA; Roghani, M; Sadr, SS; Suha, AJ | 1 |
Gao, DS; Hu, JM; Xi, W; Yin, L; Zhong, C | 1 |
Baluchnejadmojarad, T; Hashemi, P; Nazari-Serenjeh, M; Ramazi, S; Roghani, M; Tashakori-Miyanroudi, M | 1 |
Delandre, C; Fujimoto, S; Haginoya, K; Hamano, SI; Hirose, S; Inoue, Y; Ishii, A; Kaneko, S; Miyamoto, H; Moore, AW; Morimoto, M; Oguni, H; Ohmori, I; Osaka, H; Osawa, M; Pai, YJ; Raveau, M; Shimohata, A; Sudo, G; Suzuki, T; Takahashi, Y; Tatsukawa, T; Uematsu, M; Yamakawa, K | 1 |
Christian-Hinman, CA; Cutia, CA; Ge, X; Leverton, LK; Raetzman, LT; Youssef, R | 1 |
Beck, J; Bock, HH; Freiman, TM; Jabbarli, R; Kleemann, T; Puhahn-Schmeiser, B | 1 |
Huang, L; Lin, A; Lü, Y; Qin, Z; Song, J; Yang, W; Yu, W; Zhang, W; Zhong, F | 1 |
Dong, D; Guo, L; Wang, F; Wu, B; Wu, Z; Zhang, T | 1 |
Baluchnejadmojarad, T; Fahanik-Babaei, J; Mohamadi-Zarch, SM; Ramazi, S; Roghani, M | 1 |
Ding, J; Li, Y; Liu, L; Wang, Q; Wang, X; Xia, L; Zhang, Y | 1 |
Duveau, V; Evrard, A; Gurrell, R; Iredale, P; Roucard, C; Ruggiero, C | 1 |
Becker, AJ; Cases-Cunillera, S; Hamed, M; Müller, P; Opitz, T; Pitsch, J; Pohlentz, MS; Schoch, S; Surges, R; Vatter, H | 1 |
Behzadi, G; Davoudi, S; Hosseinmardi, N; Janahmadi, M; Khatibi, VA; Mirnajafi-Zadeh, J; Mohammadi, M; Nazari, M; Rahdar, M; Raoufy, MR; Rezaei, M | 1 |
Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H | 1 |
Antony, H; Audinat, E; Bedner, P; Breuer, A; Brosseron, F; Heneka, MT; Henning, L; Müller, J; Seifert, G; Singh, P; Steinhäuser, C | 1 |
Barheier, N; Häussler, U; Kilias, A; Ruther, P; Tulke, S | 1 |
Babae, JF; Jogataei, MT; Mohammadi, E; Nikbakht, F; Vazifekhah, S | 1 |
Babaei, JF; Hashemi, P; Nikbakht, F; Vazifekhah, S | 1 |
Krook-Magnuson, E; Smith, MM; Stieve, BJ | 1 |
Hu, D; Liu, J; Ma, Y; Tang, F; Yan, Y; Zhang, Z | 1 |
Dahal, A; Govindarajan, K; Kar, S | 1 |
Li, J; Sha, L; Xu, Q | 1 |
Ahmadi, S; Hashemi, P | 1 |
Hashemi, P; Izadpanah, E; Moloudi, MR; Vahabzadeh, Z | 1 |
Biagini, G; Costa, AM; Gol, M; Lucchi, C | 1 |
Bedner, P; Henning, L; Khan, D; Lülsberg, F; Muhammad, S; Müller, J; Prinz, M; Steinhäuser, C | 1 |
Chen, B; Guo, Y; Jiang, L; Lin, A; Lin, P; Tao, K; Xu, D; Zhang, H | 1 |
Chen, C; Dong, X; Fan, J; Gong, L; Huang, X; Jiang, J; Lin, D; Shen, W; Tang, Y; Wang, X; Xie, Y; Xu, A; Zeng, L; Zhang, X | 1 |
Crotty, KM; Harbin, NH; Hepler, JR; Hurst, C; Lustberg, DJ; Pare, J; Seyfried, NT; Smith, Y; Waters, AL; Weinshenker, D; Yeligar, SM | 1 |
Behzadi, G; Davoudi, S; Dehghan, S; Hosseinmardi, N; Janahmadi, M; Javan, M; Khatibi, VA; Mirnajafi-Zadeh, J; Nazari, M; Rahdar, M; Raoufy, MR; Rezaei, M; Salimi, M | 1 |
Christian-Hinman, CA; Cutia, CA; Leverton, LK | 1 |
Du, TT; Gao, Y; Han, CL; Li, RP; Liang, K; Liu, C; Meng, FG; Shi, L; Wang, HZ; Wang, Q; Xue, T; Zhang, JG; Zhang, LW; Zhang, MX; Zhao, XM; Zhou, SY | 1 |
Kovac, S; Saadi, A; Sandouka, S; Shekh-Ahmad, T; Taiwo, RO | 1 |
Cao, Q; Guo, Y; He, J; Lin, A; Xu, D; Yang, X | 1 |
Avoli, M; Fisher, TAJ; Kennedy, TE; Lévesque, M; Wang, S | 1 |
Lieb, A; Mutti, A; Schwarzer, C; Widmann, M | 1 |
Bukovac, A; Drexel, M; Matulewicz, P; Rahimi, S; Ramos-Prats, A; Salami, P; Schmuck, A; Tasan, RO | 1 |
Boon, P; Carrette, E; Christiaen, E; Craey, E; Descamps, B; Goossens, MG; Larsen, LE; Raedt, R; Vanhove, C; Vonck, K | 1 |
Auer, T; Erker, T; Schreppel, P; Schwarzer, C | 1 |
Chetkovich, DM; Foote, KM; Han, Y; Heuermann, RJ; Lyman, KA; Mandikian, D; Michailidis, IE; Swanson, GT; Trimmer, JS | 1 |
Gupta, K; Schnell, E | 1 |
Baekelandt, V; Boon, P; Carrette, E; De Bundel, D; Delbeke, J; Desloovere, J; Goossens, MG; Larsen, LE; Merckx, C; Meurs, A; Raedt, R; Van den Haute, C; Vonck, K; Wadman, W | 1 |
Anjum, M; Brandt, C; Gericke, B; Hillmann, P; Kaczmarek, E; Löscher, W; Schidlitzki, A; Theilmann, W; Twele, F; Welzel, L | 1 |
Chen, Y; Deng, J; Liu, X; Liu, Y; Ou, S; Tan, C; Wang, T; Xu, T; Yang, J; Yu, X; Yuan, J | 1 |
Biagini, G; Lukoyanov, NV; Rosal Lustosa, Í; Soares, JI | 1 |
Anjum, M; Löscher, W; Schidlitzki, A; Twele, F; Welzel, L | 1 |
Berger, TC; Etholm, L; Heuser, K; Hjorthaug, HS; Nome, CG; Selmer, KK; Taubøll, E; Vigeland, MD | 1 |
Chen, J; Chen, W; Li, L; Ma, Z; Wang, H; Yao, G | 1 |
Hong, J; Jung, UJ; Kim, SR; Lee, JM; Yoon, D | 1 |
Clarkson, C; Hasenoehrl, MG; Rubio, ME; Smeal, RM; White, JA; Wilcox, KS | 1 |
Ampig, K; Bui, AD; Ciernia, AV; Felong, S; Gschwind, T; Kim, HK; Nguyen, TM; Soltesz, I; Suh, D; Wood, MA | 1 |
Boon, P; Christiaen, E; Descamps, B; Goossens, MG; Larsen, LE; Raedt, R; Vanhove, C | 1 |
Inoue, T; Sada, N; Suto, S; Suzuki, M; Usui, S | 1 |
Bahri, MA; Becker, G; Germonpré, C; Giacomelli, F; Lemaire, C; Luxen, A; Mievis, F; Plenevaux, A; Raedt, R; Rogister, B; Salmon, E; Seret, A; Serrano, ME | 1 |
Biagini, G; Costa, AM; Lucchi, C; Rosal Lustosa, Í; Simonini, C | 1 |
Baluchnejadmojarad, T; Fahanik-Babaei, J; Mohamadi-Zarch, SM; Nazari-Serenjeh, M; Nourabadi, D; Ramazi, S; Roghani, M; Tashakori-Miyanroudi, M | 1 |
Alberch, J; Delgado-García, JM; Fernández-García, S; Giralt, A; Gruart, A; Hervé, D; Longueville, S; Sancho-Balsells, A | 1 |
Ali, MK; Alireza, MS; Babae, JF; Hashemi, P; Nikbakht, F; Vazifehkhah, S | 1 |
Khanizadeh, AM; Mojarad, TB; Nikbakht, F; Vazifehkhah, S | 1 |
Dong, X; Fan, M; Hao, X; Huang, X; Jiang, P; Wang, X; Xie, Y; Xu, P; Zeng, L | 1 |
Batool, A; Bauer, S; Brennan, GP; Brindley, E; Connolly, NMC; Costard, LS; Del Gallo, F; Delanty, N; El-Naggar, H; Engel, T; Fabene, P; Heiland, M; Henshall, DC; Hill, TDM; Jimenez-Mateos, EM; Mamad, O; Mooney, C; Neubert, V; Norwood, B; Prehn, JHM; Raoof, R; Reschke, CR; Rosenow, F; Salvetti, B; Sanz-Rodriguez, A | 1 |
He, H; Huang, Y; Lin, L; Pan, X; Wang, L; Wu, Y; Zhang, Y; Zhao, Y | 1 |
Alalqam, R; Alves, M; Beamer, E; Conte, G; De Diego-Garcia, L; Engel, T; Henshall, DC; Lucas, JJ; Mendez, R; Ocampo, A; Ollà, I; Parras, A | 1 |
Barbier, EL; Bretagnolle, L; Depaulis, A; Fauvelle, F; Guo, J; Hamelin, S; Labriji, W; Liu, C; Mazière, L; Parrot, S; Stupar, V | 1 |
Kavaye Kandeda, A; Mbomo Ayissi, RE; Ngo Bum, E; Ojong, L; Okomolo Moto, FC; Omam Omam, JP | 1 |
Cai, X; Chen, C; Chen, Z; Cheng, H; Fan, X; Liu, J; Shen, Y; Tan, B; Tan, N; Wang, S; Wang, Y; Wu, X; Yu, J | 1 |
Gailus, B; Gericke, B; Hampel, P; Johne, M; Kaila, K; Käufer, C; Löscher, W; Römermann, K; Schidlitzki, A; Theilmann, W; Töllner, K; Vogel, A | 1 |
Beck, J; Brandt, A; Doostkam, S; Freiman, TM; Haas, CA; Häussler, U; Puhahn-Schmeiser, B; Scheiwe, C; Zentner, J | 1 |
Metcalf, CS; Thomson, KE; West, PJ; Wilcox, KS | 1 |
Clement, EM; Greenfield, LJ; Kang, YJ; Lee, SH; Park, IH; Smith, BN | 1 |
Che, NW; Luan, ZL; Sun, XW; Wang, GY; Yan, DB; Yin, J; Zhang, C | 1 |
Barker-Haliski, M; Knox, KM; Koneval, Z; Mizuno, S; White, HS; Zierath, DK | 1 |
Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D | 1 |
Carlson, S; Gregory-Flores, A; Hinojo-Perez, A; Olson, A; Sharma, S; Thippeswamy, T | 1 |
Binder, DK; Cullion, K; Garcia, TA; Pedapati, EV; Peterson, AR; Tiwari-Woodruff, SK | 1 |
Corinne, R; Venceslas, D | 1 |
Kanamori, K | 1 |
Adongo, DW; Mante, PK; Woode, E | 1 |
Anderson, AE; Davanger, S; Dosa, ZJ; Egbenya, DL; Hussain, S; Lai, YC; Sørensen, JB | 1 |
Chen, L; Dong, J; Kai, J; Wang, Q; Wu, M; Zeng, LH; Zhu, F | 1 |
Becker, A; Bedner, P; Deshpande, T; Henneberger, C; Herde, MK; Li, T; Schwarz, MK; Steinhäuser, C; Vatter, H | 1 |
Chi, Y; Guan, J; Guo, Y; Li, X; Lu, Z; Rao, J; Wu, B; Xiao, K; Xu, Q; Xu, Y; Xue, S | 1 |
Qi, X; Qiao, Z; Qu, Z; Su, F; Sun, J; Wang, H; Zhao, H; Zhu, Y | 1 |
Li, Y; Lu, S; Lu, X; Ma, Y; Tian, X; Wang, W; Wang, X; Xu, D; Xu, X; Yang, Y; Zhang, Y; Zheng, F | 1 |
Ji, Y; Jiang, N; Kuang, P; Lao, W; Lin, W; Wang, Z; Yin, T; Zhao, Y; Zhu, H | 1 |
Bankstahl, JP; Bankstahl, M; Bascuñana, P; Bengel, FM; Brackhan, M; Ross, TL | 1 |
Naderali, E; Nikbakht, F; Ofogh, SN; Rasoolijazi, H | 1 |
Egert, U; Froriep, UP; Haas, CA; Häussler, U; Heining, K; Kilias, A | 1 |
Birot, G; Contestabile, A; Kiss, JZ; Michel, CM; Quairiaux, C; Schaller, K; Seeck, M; Sheybani, L | 1 |
Cao, B; Chen, M; Dang, X; Han, S; Jia, C; Jiao, H; Liu, Y; Niu, Q; Wei, L | 1 |
Ali, AB; Khalil, A; Khan, AA; Shekh-Ahmad, T; Walker, MC | 1 |
Jia, YJ; Li, TR; Lv, RJ; Ma, C; Qiu, WY; Shao, XQ; Wang, Q | 1 |
Abrams, E; Buckmaster, PS; Clark, K; Demars, F; Wyeth, MS | 1 |
Chen, N; Ge, M; Han, CL; Hu, W; Li, L; Liu, YP; Meng, FG; Meng, WJ; Wang, KL; Zhang, JG; Zhao, XM | 1 |
Banerjee, M; Hariharakrishnan, J; Kar, S; Kodam, A; Maulik, M; Ourdev, D; Wang, Y | 1 |
Boisgard, R; Bouilleret, V; Buvat, I; Caillé, F; Jego, B; Nguyen, DL; Pottier, G; Truillet, C; Wimberley, C | 1 |
Fritz, KS; Gano, LB; Gomez, J; Liang, LP; Michel, CR; Patel, M; Reisdorph, N; Ryan, K; Vassilopoulos, A | 1 |
Blauwblomme, T; Capelle, L; Chever, O; Couillin, I; Dossi, E; Guinard, E; Huberfeld, G; Le Bert, M; Moulard, J; Pallud, J; Rouach, N; Vasile, F | 1 |
Fritschy, JM; Gfeller, T; Gschwind, T; Knuesel, I; Lafourcade, C; Rambousek, L; Zaichuk, M | 1 |
Dhir, A | 1 |
Becker, AJ; de Curtis, M; Elger, CE; Gnatkovsky, V; Kuehn, JC; Müller, JA; Pitsch, J; Schoch, S; van Loo, KMJ; Vatter, H | 1 |
Jia, YJ; Li, TR; Lv, RJ; Shao, XQ; Wang, Q; Zhang, P | 1 |
Chen, Y; Du, T; Jiang, Y; Liu, D; Liu, Y; Meng, D; Shi, L; Zhang, J; Zhang, X; Zhu, G | 1 |
Anderson, AE; Davanger, S; Egbenya, DL; Hussain, S; Lai, YC; Xia, J | 1 |
Gams Massi, D; Kpadonou, C; Ndiaye, M; Ouedraogo, M; Samb, A; Sow, AD; Toffa, DH | 1 |
Albertini, G; Buckinx, A; De Bundel, D; Denewet, L; Smolders, I; Van Den Herrewegen, Y; Van Eeckhaut, A | 1 |
Bernard, H; Depaulis, A; Greenberg, D; Kalozoumi, G; Kel-Margoulis, O; Sanoudou, D; Soreq, H; Vafiadaki, E | 1 |
Chang, JH; Hong, J; Jeon, MT; Jung, UJ; Kim, DW; Kim, S; Kim, SR; Kwon, JY; Moon, GJ; Shin, M | 1 |
Burman, RJ; Parrish, RR | 1 |
Audinat, E; Nikolic, L; Nobili, P; Shen, W; Ulmann, L; Virenque, A | 1 |
Chen, T; Deng, Y; Sha, L; Shen, Y; Xu, Q | 1 |
Chen, N; Ge, M; Han, CL; Hu, W; Liu, YP; Meng, FG; Wang, KL; Zhang, JG; Zhao, XM | 1 |
Jiang, Z; Ping, A; Wang, Y; Xu, K; Zhang, F; Zheng, Y; Zhu, J; Zhu, W | 1 |
Atanasova, D; Galchev, T; Kortenska, L; Lazarov, N; Marinov, P; Shishmanova-Doseva, M; Tchekalarova, J | 1 |
Becker, AJ; Bikbaev, AF; Blaess, S; Dietrich, D; Heine, M; Martinez-Chavez, E; Müller, JA; Pitsch, J; Rummel, CK; Schoch, S; van Loo, KMJ | 1 |
Cheng, B; Cheng, Y; Fu, H; Huang, W; Li, X; Li, Y; Lu, P; Luo, H; Qi, Z; Rong, Z; Wang, X; Yao, Y; Ye, X; Zhang, YW; Zheng, H; Zheng, W | 1 |
Chen, Y; Du, T; Liu, D; Liu, Y; Shi, L; Yuan, T; Zhang, J; Zhang, X; Zhu, G | 1 |
Chen, Q; Huang, Z; Li, MH; Ma, WN; Sun, ZM; Zhao, XY | 1 |
Li, X; Wang, X; Yan, J; Yang, H; Yuan, Y | 1 |
Binder, DK; Peterson, AR | 1 |
Belali, R; Mohammad Khanizadeh, A; Nikbakht, F; Rasoolijazi, H | 1 |
Almeida, SG; Baptista, HX; Brazete, CS; Leite, JM; Lukoyanov, NV; Lukoyanova, AN; Maia, GH; Soares, JI | 1 |
Carron, S; Dezsi, G; Jones, NC; Nithianantharajah, J; Ozturk, E | 1 |
Al Hamda, MH; Dong, J; Xu, K; Yao, Y; Zhang, A; Zhu, M; Zhu, X | 1 |
Hong, Z; Sun, W; Wang, Y; Wu, X; Xu, L; Zhang, L; Zhu, G | 1 |
Adeyemi, OO; Afolayan, OO; Ajayi, AM; Ben-Azu, B; Ishola, IO; James, AB; Ojo, ES; Umukoro, S | 1 |
Kouroupi, G; Koutsoudaki, PN; Matsas, R; Miltiadous, P; Stamatakis, A; Stylianopoulou, F | 1 |
Haas, CA; Ringwald, J; Tinnes, S | 1 |
Agresti, A; Antonelli, A; Aronica, E; Bianchi, ME; Carli, M; Iori, V; Iyer, AM; Maroso, M; Ravizza, T; Rizzi, M; Vertemara, R; Vezzani, A | 1 |
Lin, KC; Wang, CC; Wang, SJ | 1 |
Gu, B; He, XP; Joshi, RB; Liu, G; McNamara, JO; Rodriguiz, RM; Wackerle, HD; Wetsel, WC | 1 |
Albertson, AJ; Buckingham, SC; Davis Haselden, W; Hablitz, JJ; Lubin, FD; Mascia, KL; Ryley Parrish, R | 1 |
Börgers, C; Dugladze, T; Gloveli, T; Gurgenidze, S; Haas, CA; Häussler, U; Kopell, NJ; Maziashvili, N; Meier, JC; Vida, I; Winkelmann, A | 1 |
Chen, N; Ge, Y; Hu, W; Liu, C; Meng, FG; Yan, N; Zhang, JG | 1 |
Dou, W; Feng, J; Jin, L; Li, W; Sha, L; Sha, Z; Shen, Y; Wang, J; Wang, N; Wang, X; Wen, B; Wu, L; Wu, X; Xing, X; Xu, Q; Yao, Y | 1 |
Baluchnejadmojarad, T; Khalili, M; Kiasalari, Z; Rahmati, B; Roghani, M | 1 |
Avoli, M; Lévesque, M | 1 |
Brotons-Mas, JR; Cid, E; de la Prida, LM; Inostroza, M; Laurent, F | 1 |
Matthews, SA; Samson, KK; Simeone, KA; Simeone, TA | 1 |
Liang, LP; Patel, M; Rivard, C; Ryan, K | 1 |
Sha, LZ; Sha, ZQ; Shen, Y; Wu, XF; Xu, Q | 1 |
Atanasova, D; Kortenska, L; Lazarov, N; Lozanov, V; Markova, P; Mitreva, R; Moyanova, S; Pechlivanova, D; Petkova, Z; Popov, D; Stoynev, A; Tchekalarova, J | 1 |
Buckmaster, PS; Gulland, FM; Toyoda, I; Van Bonn, W; Wen, X | 1 |
Gulland, FM; Ramsdell, JS | 1 |
Rosania, K | 1 |
Chabrol, T; David, O; Depaulis, A; Francis, F; Hamelin, S; Khalaf-Nazzal, R; Pouyatos, B | 1 |
Elbrønd-Bek, H; Gøtzsche, CR; Olling, JD; Waterfield, A; Woldbye, DP; Wörtwein, G | 1 |
Hsieh, CL; Hsu, HC; Lin, WJ; Lin, YW; Liu, CH; Liu, HJ | 1 |
Bhowmik, M; Pottoo, FH; Vohora, D | 1 |
Dragunow, M; During, MJ; Fong, DM; Glass, M; Lawlor, PA; McRae, M; Mouravlev, A; Wu, A; Young, D | 1 |
Choi, BY; Choi, HC; Kim, JH; Lee, DW; Lee, SH; Sohn, M; Song, HK; Suh, SW | 1 |
Atanasova, D; Ivanova, NM; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Pechlivanova, DM; Stoynev, A; Tchekalarova, JD | 1 |
Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W | 1 |
Bankstahl, M; Klein, S; Löscher, W | 1 |
Grande, V; Manassero, G; Vercelli, A | 1 |
Day, B; Fulton, R; Liang, LP; Patel, M; Rowley, S; Shimizu, T | 1 |
Depaulis, A; Laharie, AM; Nitta, N; Nozaki, K; Shima, A; Suzuki, F | 1 |
Avoli, M; Bernard, C; Lévesque, M | 1 |
Bankstahl, M; Klein, S; Löscher, W; Römermann, K; Twele, F | 1 |
Hasanzadeh, G; Khamse, S; Mohammadian, M; Roghani, M; Sadr, SS | 1 |
Chu, K; Hakimova, H; Jeon, D; Jeong, B; Kim, S; Lee, SK | 1 |
Bedner, P; Jefferys, J; Steinhäuser, C | 1 |
Chen, X; Chen, Y; Cheng, L; Deng, W; Li, J; Li, Y; Lü, Y; Mi, X; Wang, N; Wang, X; Wang, Z; Xu, X; Zhang, Y | 1 |
Chen, B; Chen, X; Liu, SY; Lu, LX; Shu, HF; Wang, FX; Xiong, XY; Yang, H; Yang, QW; Zheng, X | 1 |
Chan, JY; Chang, AY; Chao, YM; Ho, YH; Lin, YT; Wu, CW | 1 |
de Lanerolle, NC; Hitchens, TK; Pan, JW; Pearce, PS; Rapuano, A; Wu, Y | 1 |
Kim, CH | 1 |
Genov, R; Kassiri, H; Perez Velazquez, JL; Salam, MT | 1 |
Aronica, E; Baayen, JC; Bertollini, C; Cifelli, P; Di Castro, MA; Limatola, C; Palma, E; Roseti, C; Ruffolo, G; van Vliet, EA; Vezzani, A | 1 |
Jeong, KH; Kim, SR; Lee, DS | 1 |
Kitagawa, H; Yutsudo, N | 1 |
Drexel, M; Jagirdar, R; Kirchmair, E; Sperk, G; Tasan, RO | 1 |
Aronica, E; Boison, D; Bright, KA; Gorter, J; Hanthorn, M; Lytle, NK; Shen, HY; van Vliet, EA | 1 |
Boon, P; Carrette, E; Dauwe, I; Delbeke, J; Gadeyne, S; Raedt, R; Sprengers, M; Van Nieuwenhuyse, B; Vonck, K; Wadman, WJ | 1 |
Ge, H; Guo, M; Hou, X; Jiang, Z; LaChaud, G; Lin, Z; Liu, L; Long, Y; Mu, L; Park, SH; Pu, S; Shen, H; Shen, J; Shi, C; Song, Y; Sun, J; Wang, H; Wang, X; Xie, C; Yao, L; Zarringhalam, A; Zhu, M | 1 |
Egert, U; Haas, CA; Häussler, U; Kilias, A; Rinas, K | 1 |
Barth, AM; Jones, RT; Mody, I; Ormiston, LD | 1 |
Christiansen, SH; Cifra, A; Gøtzsche, CR; Kokaia, M; Ledri, LN; Melin, E; Woldbye, DP | 1 |
Armstrong, C; Bezaire, MJ; Broderick, J; Lee, SH; Soltesz, I; Wang, J; Yeun Lee, S | 1 |
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19 review(s) available for kainic acid and Benign Psychomotor Epilepsy, Childhood
Article | Year |
---|---|
A Mesiotemporal Lobe Epilepsy Mouse Model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Sex Factors; Species Specificity | 2017 |
Curcumin in epilepsy disorders.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Brain; Curcuma; Curcumin; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Rats; Seizures | 2018 |
The kainic acid model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Humans; Kainic Acid | 2013 |
Domoic acid epileptic disease.
Topics: Aged; Aged, 80 and over; Aging; Amnesia; Animal Diseases; Animals; Behavior, Animal; Bivalvia; Epilepsy; Epilepsy, Temporal Lobe; Female; Food Contamination; Hippocampus; Humans; Kainic Acid; Male; Marine Toxins; Middle Aged; Neuromuscular Depolarizing Agents; Neurotoxins; Olfactory Pathways; Rats; Recurrence; Sea Lions; Seizures; Shellfish Poisoning | 2014 |
Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Nerve Net; Pilocarpine; Temporal Lobe | 2016 |
Chemically-induced TLE models: Topical application.
Topics: Administration, Topical; Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Nerve Net; Pilocarpine; Temporal Lobe | 2016 |
Basic science and epilepsy: experimental epilepsy surgery.
Topics: Amygdala; Animals; Anticonvulsants; Cats; Combined Modality Therapy; Corpus Callosum; Drug Evaluation; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Models, Animal; Neurosurgical Procedures; Nootropic Agents; Pyrrolidinones; Rats; Seizures; Stereotaxic Techniques | 2001 |
Epilepsy-based changes in hippocampal excitability: causes and effects.
Topics: Action Potentials; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Nerve Net; Seizures; Synapses | 2006 |
Selective degeneration and synaptic reorganization of hippocampal interneurons in a chronic model of temporal lobe epilepsy.
Topics: Afferent Pathways; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Nerve Degeneration; Nerve Net; Neural Inhibition; Pyramidal Cells; Synapses | 2006 |
Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Fever; Hippocampus; Hypoxia; Kainic Acid; Kindling, Neurologic; Pilocarpine; Rats; Recurrence; Seizures; Tetanus Toxin | 2007 |
[Changes in spontaneous epileptic activity after selective intrahippocampal transection in a model of chronic mesial temporal lobe epilepsy].
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Kindling, Neurologic; Mice; Neuronal Plasticity; Neurosurgical Procedures | 2008 |
Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Survival; Central Nervous System; Electrophysiology; Epilepsy; Epilepsy, Temporal Lobe; Injections; Kainic Acid; Limbic System; Neurons; Pyrrolidines; Rats | 1981 |
Axonal sprouting and synaptogenesis in temporal lobe epilepsy: possible pathogenetic and therapeutic roles of neurite growth inhibitory factors.
Topics: Alzheimer Disease; Animals; Axons; Brain; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Nerve Growth Factors; Neuronal Plasticity; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Synapses | 1995 |
Kainate, a double agent that generates seizures: two decades of progress.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Neural Inhibition; Presynaptic Terminals; Pyramidal Cells; Receptors, Kainic Acid; Seizures; Synapses | 2000 |
Cell death and synaptic reorganizations produced by seizures.
Topics: Animals; Cell Death; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Neuronal Plasticity; Rats; Seizures; Status Epilepticus; Synaptic Transmission | 2001 |
Developmental differences in the neurobiology of epileptic brain damage.
Topics: Age Factors; Animals; Brain Damage, Chronic; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Seizures | 1992 |
Ammon's horn sclerosis: its pathogenesis and clinical significance.
Topics: Animals; Brain Ischemia; Cell Survival; Epilepsy, Temporal Lobe; Gerbillinae; Glutamates; Glutamic Acid; Hippocampus; Humans; Hypoxia; Kainic Acid; Models, Neurological; Neurons; Sclerosis; Status Epilepticus; Synaptic Transmission; Temporal Lobe; Terminology as Topic | 1990 |
Experimental models of temporal lobe epilepsy: new insights from the study of kindling and synaptic reorganization.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Limbic System; Models, Neurological; Neural Pathways; Neuronal Plasticity; Sclerosis | 1990 |
Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.
Topics: Animals; Binding Sites; Brain; Calcium; Disease Models, Animal; Drug Interactions; Epilepsy, Temporal Lobe; Glucose; Glutamates; Glutamic Acid; Humans; Kainic Acid; Limbic System; Pyrrolidines; Status Epilepticus; Zinc | 1985 |
427 other study(ies) available for kainic acid and Benign Psychomotor Epilepsy, Childhood
Article | Year |
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Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Diastole; Disease Models, Animal; Echocardiography; Electrocardiography; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fibrosis; Heart Rate; Kainic Acid; Mitral Valve; Myocardium; Rats; Status Epilepticus; Sudden Unexpected Death in Epilepsy; Ventricular Dysfunction; Ventricular Remodeling; Video Recording | 2021 |
G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Mice; Receptors, Metabotropic Glutamate | 2022 |
Intravenous kainic acid induces status epilepticus and late onset seizures in mice.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus | 2021 |
Topics: Animals; Connaraceae; Disease Models, Animal; Epilepsy, Temporal Lobe; Genes, Immediate-Early; Humans; Kainic Acid; Mice; Plant Extracts | 2021 |
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microinjections; Seizures; Status Epilepticus | 2022 |
Effects of perampanel on cognitive behavior and GluR1 expression in immature mice of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Morris Water Maze Test; Neurons; Nitriles; Pyridones; Receptors, AMPA; Transcription Factor AP-1 | 2022 |
Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice.
Topics: Animals; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Rats; Seizures | 2022 |
Loss of efferent projections of the hippocampal formation in the mouse intrahippocampal kainic acid model.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures | 2022 |
Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Fibroblast Growth Factors; Hippocampus; Kainic Acid; Mice; Seizures | 2022 |
Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus | 2022 |
Ferulic Acid Attenuates Kainate-induced Neurodegeneration in a Rat Poststatus Epilepticus Model.
Topics: Animals; Coumaric Acids; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Nitrites; Rats; Rats, Wistar; Status Epilepticus | 2023 |
Long-term development of dynamic changes in neurovascular coupling after acute temporal lobe epilepsy.
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Neurovascular Coupling | 2022 |
Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy.
Topics: Acetylcarnitine; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Rats; Seizures; Status Epilepticus | 2022 |
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Genome-Wide Association Study; Hippocampus; Homeodomain Proteins; Humans; Kainic Acid; Mice; Seizures; Synaptic Transmission | 2022 |
Phenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Phenotype; Seizures | 2022 |
Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution.
Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Mice, Neurologic Mutants; Neurons | 2022 |
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Topics: Animals; Caspases; Epilepsy; Epilepsy, Temporal Lobe; Humans; Inflammasomes; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, G-Protein-Coupled; Status Epilepticus | 2022 |
The Clock gene regulates kainic acid-induced seizures through inhibiting ferroptosis in mice.
Topics: Animals; CLOCK Proteins; Epilepsy, Temporal Lobe; Ferroptosis; Kainic Acid; Mice; Mice, Knockout; PPAR gamma; Seizures | 2022 |
Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy.
Topics: Acetophenones; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice | 2022 |
Inhibiting SRC activity attenuates kainic-acid induced mouse epilepsy via reducing NR2B phosphorylation and full-length NR2B expression.
Topics: Animals; Calpain; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Phosphorylation; Seizures | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Seizures | 2022 |
Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammasomes; Interleukin-1beta; Kainic Acid; Mice; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Pilocarpine; Seizures; Status Epilepticus | 2022 |
The Glycolysis Inhibitor 2-Deoxy-D-Glucose Exerts Different Neuronal Effects at Circuit and Cellular Levels, Partially Reverses Behavioral Alterations and does not Prevent NADPH Diaphorase Activity Reduction in the Intrahippocampal Kainic Acid Model of Te
Topics: Animals; Deoxyglucose; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Glucose; Glycolysis; Hippocampus; Kainic Acid; NADP; NADPH Dehydrogenase; Neurons | 2023 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2022 |
Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mice, Knockout; Microglia; Seizures; Status Epilepticus; Tumor Necrosis Factor-alpha | 2023 |
Integration of the CA2 region in the hippocampal network during epileptogenesis.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Seizures | 2023 |
Evaluation the cognition-improvement effects of N-acetyl cysteine in experimental temporal lobe epilepsy in rat.
Topics: Acetylcysteine; Animals; Cognition; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Maze Learning; Memory Disorders; Rats; TOR Serine-Threonine Kinases | 2023 |
Investigating the mechanism of antiepileptogenic effect of apigenin in kainate temporal lobe epilepsy: possible role of mTOR.
Topics: Animals; Apigenin; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mossy Fibers, Hippocampal; TOR Serine-Threonine Kinases | 2023 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Mice; Seizures | 2023 |
TMT-based proteomics profile reveals changes of the entorhinal cortex in a kainic acid model of epilepsy in mice.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Proteomics; Seizures; Tandem Mass Spectrometry | 2023 |
Administration of Kainic Acid Differentially Alters Astrocyte Markers and Transiently Enhanced Phospho-tau Level in Adult Rat Hippocampus.
Topics: Adult; Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Rats; Seizures; tau Proteins | 2023 |
Long-term outcomes of classic and novel anti-seizure medication in a kainate-induced model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Valproic Acid | 2023 |
Alpha-Pinene Exerts Antiseizure Effects by Preventing Oxidative Stress and Apoptosis in the Hippocampus in a Rat Model of Temporal Lobe Epilepsy Induced by Kainate.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Oxidative Stress; Rats; Rats, Wistar; Seizures | 2023 |
Anticonvulsant Effects of Royal Jelly in Kainic Acid-Induced Animal Model of Temporal Lobe Epilepsy Through Antioxidant Activity.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 2023 |
Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Kainic Acid; Neurosteroids; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2023 |
TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; MAP Kinase Kinase Kinases; Mice; Mice, Transgenic; Microglia; Transforming Growth Factor beta | 2023 |
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
Topics: Animals; Apoptosis; Caspase 1; Caspase 3; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Seizures | 2023 |
Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Microglia; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2023 |
RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Oxidative Stress; Pyramidal Cells; RGS Proteins; Seizures; Status Epilepticus | 2023 |
Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior.
Topics: Animals; Anxiety; Basolateral Nuclear Complex; Epilepsy; Epilepsy, Temporal Lobe; Glycolysis; Hippocampus; Kainic Acid | 2023 |
Sex and Estrous Cycle Stage Shape Left-Right Asymmetry in Chronic Hippocampal Seizures in Mice.
Topics: Animals; Epilepsy, Temporal Lobe; Estrous Cycle; Female; Hippocampus; Kainic Acid; Male; Mice; Seizures; Temporal Lobe | 2023 |
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Neuroinflammatory Diseases; NF-kappa B; Ryanodine Receptor Calcium Release Channel; Seizures; Serpins; Signal Transduction | 2023 |
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Neurons; Oxidative Stress; Rats; Reactive Oxygen Species; Seizures; Sestrins; Status Epilepticus; Transcription Factors | 2023 |
GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice.
Topics: Animals; Epilepsy, Temporal Lobe; Kainic Acid; Lipopolysaccharides; Mice; Microglia; Seizures | 2023 |
CA3 principal cell activation triggers hypersynchronous-onset seizures in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Seizures; Status Epilepticus | 2023 |
Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Solvents | 2023 |
The role of subicular VIP-expressing interneurons on seizure dynamics in the intrahippocampal kainic acid model of temporal lobe epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Seizures; Vasoactive Intestinal Peptide | 2023 |
Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study.
Topics: Animals; Brain; Brain Mapping; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neural Pathways; Rats, Sprague-Dawley; Seizures | 2019 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2 | 2020 |
Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.
Topics: Amino Acid Sequence; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; HEK293 Cells; Humans; Ion Channel Gating; Kainic Acid; Membrane Proteins; Mice, Inbred C57BL; Peroxins; Phosphorylation; Phosphoserine; Protein Subunits; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
Neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy.
Topics: Animals; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Hippocampus; Humans; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; Mice, Transgenic; Nerve Net; Wnt Proteins; Wnt Signaling Pathway | 2019 |
Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Clozapine; Electroencephalography; Epilepsy, Temporal Lobe; Genetic Vectors; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures | 2019 |
Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model.
Topics: Animals; Anxiety; Azabicyclo Compounds; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Seizures; Signal Transduction; Status Epilepticus; Triazines | 2020 |
CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; MAP Kinase Signaling System; Mice; Neurons; Receptors, CXCR; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses | 2019 |
Neuroplasticity in Cholinergic Projections from the Basal Forebrain to the Basolateral Nucleus of the Amygdala in the Kainic Acid Model of Temporal Lobe Epilepsy.
Topics: Acetylcholine; Amygdala; Animals; Basal Forebrain; Cholinergic Neurons; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Neuronal Plasticity; Rats, Wistar; Vesicular Acetylcholine Transport Proteins | 2019 |
A face-to-face comparison of the intra-amygdala and intrahippocampal kainate mouse models of mesial temporal lobe epilepsy and their utility for testing novel therapies.
Topics: Amygdala; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice | 2020 |
Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis.
Topics: Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epilepsy, Temporal Lobe; Galanin; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genetic Predisposition to Disease; Histone Deacetylases; Kainic Acid; Male; Mice; Neuroglia; Neurons; Osteopontin; Receptors, Dopamine D1; Sequence Analysis, DNA; Sequence Analysis, RNA | 2019 |
LncRNA-UCA1 inhibits the astrocyte activation in the temporal lobe epilepsy via regulating the JAK/STAT signaling pathway.
Topics: Animals; Astrocytes; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Genetic Vectors; Hippocampus; Janus Kinase 1; Kainic Acid; Male; Memory; Morris Water Maze Test; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Signal Transduction; STAT3 Transcription Factor | 2020 |
No Synergistic Effect of Silibinin and Morin in a Kainic Acid-Induced Epileptic Mouse Model.
Topics: Animals; Dentate Gyrus; Drug Synergism; Epilepsy, Temporal Lobe; Flavonoids; Kainic Acid; Mice; Seizures; Silybin | 2020 |
Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy.
Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus; Synapses | 2020 |
Optogenetic intervention of seizures improves spatial memory in a mouse model of chronic temporal lobe epilepsy.
Topics: Animals; Channelrhodopsins; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Interneurons; Kainic Acid; Mice; Optogenetics; Parvalbumins; Spatial Learning; Spatial Memory; Video Recording | 2020 |
Dynamic functional connectivity and graph theory metrics in a rat model of temporal lobe epilepsy reveal a preference for brain states with a lower functional connectivity, segregation and integration.
Topics: Animals; Brain; Brain Mapping; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Models, Animal; Nerve Net; Neural Pathways; Rats; Seizures | 2020 |
Upregulation of lactate dehydrogenase A in a chronic model of temporal lobe epilepsy.
Topics: Animals; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intraventricular; Kainic Acid; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred ICR; Seizures; Up-Regulation | 2020 |
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Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Magnetic Resonance Imaging; Membrane Glycoproteins; Nerve Tissue Proteins; Positron-Emission Tomography; Pyridines; Pyrrolidinones; Rats, Sprague-Dawley | 2020 |
Status Epilepticus Dynamics Predicts Latency to Spontaneous Seizures in the Kainic Acid Model.
Topics: Animals; Brain; Cell Death; Cell Survival; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Gamma Rhythm; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Theta Rhythm | 2020 |
Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy: Involvement of oxidative stress, inflammation and pyroptosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Male; Morphinans; Neuroprotective Agents; Oxidative Stress; Pyroptosis; Rats; Reactive Oxygen Species | 2020 |
Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Deletion; Hippocampus; Kainic Acid; Lithium; Locomotion; Mice, Inbred C57BL; Neurons; Neuroprotection; Phenotype; Pilocarpine; Receptor, trkB; Severity of Illness Index; Spatial Learning | 2020 |
Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats.
Topics: Administration, Oral; Animals; Anticonvulsants; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Metformin; Neurons; Rats; Rats, Wistar | 2020 |
The possible role of progranulin on anti-inflammatory effects of metformin in temporal lobe epilepsy.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Kainic Acid; Metformin; Progranulins; Rats | 2020 |
RNA sequencing analysis of cortex and hippocampus in a kainic acid rat model of temporal lobe epilepsy to identify mechanisms and therapeutic targets related to inflammation, immunity and cognition.
Topics: Animals; Cerebral Cortex; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Immunity; Inflammation; Kainic Acid; Male; Rats, Sprague-Dawley; Sequence Analysis, RNA; Transcriptome | 2020 |
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Circulating MicroRNA; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Muscarinic Agonists; Perforant Pathway; Pilocarpine; Rats | 2020 |
Adipose-derived stem cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Learning; Male; Maze Learning; Memory; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nerve Growth Factors; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Gene Expression; Hippocampus; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Status Epilepticus; Transcriptome | 2020 |
In vivo γ-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrophoresis, Capillary; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Metabolomics; Mice; Multivariate Analysis; Proton Magnetic Resonance Spectroscopy; Sclerosis | 2021 |
Pergularia daemia alters epileptogenesis and attenuates cognitive impairment in kainate-treated mice: Insight into anti-inflammatory mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Cameroon; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice | 2021 |
Deep brain stimulation in the medial septum attenuates temporal lobe epilepsy via entrainment of hippocampal theta rhythm.
Topics: Animals; Cognition; Deep Brain Stimulation; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Kindling, Neurologic; Learning; Memory; Mice; Mice, Inbred C57BL; Psychomotor Performance; Seizures; Septum of Brain; Theta Rhythm | 2021 |
Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Solute Carrier Family 12, Member 2 | 2021 |
Mossy fiber sprouting into the hippocampal region CA2 in patients with temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; CA2 Region, Hippocampal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mossy Fibers, Hippocampal; RGS Proteins | 2021 |
Response: Usefulness of the post-kainate spontaneous recurrent seizure model for screening for antiseizure and for neuroprotective effects.
Topics: Epilepsy, Generalized; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Neuroprotective Agents; Seizures | 2021 |
Vulnerability of cholecystokinin-expressing GABAergic interneurons in the unilateral intrahippocampal kainate mouse model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABAergic Neurons; Gene Expression; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2021 |
Inhibition of microRNA-129-2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; MicroRNAs; Rats; Receptors, GABA-A; Seizures | 2021 |
Diurnal burden of spontaneous seizures in early epileptogenesis in the post-kainic acid rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Compounding; Drug Discovery; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Temporal Lobe; Everolimus; High-Throughput Screening Assays; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Seizures; Translational Research, Biomedical | 2021 |
Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy.
Topics: Animals; Benzodioxoles; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Inflammation Mediators; Kainic Acid; Male; Proto-Oncogene Proteins c-fyn; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Telemetry | 2021 |
Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy.
Topics: Animals; Astrocytes; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Gene Knock-In Techniques; Hippocampus; Kainic Acid; Mice; Seizures; Up-Regulation | 2021 |
Faster flux of neurotransmitter glutamate during seizure - Evidence from 13C-enrichment of extracellular glutamate in kainate rat model.
Topics: Animals; Carbon Isotopes; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neurotransmitter Agents; Rats, Wistar; Seizures | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Nifedipine; Pentylenetetrazole; Pilocarpine; Plant Extracts; Rats; Rats, Sprague-Dawley | 2017 |
The calcium sensor synaptotagmin 1 is expressed and regulated in hippocampal postsynaptic spines.
Topics: Animals; Cells, Cultured; Chronic Disease; Cytoplasmic Vesicles; Dendritic Spines; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice, Knockout; Microscopy, Electron; Post-Synaptic Density; Presynaptic Terminals; Rats, Sprague-Dawley; Rats, Wistar; Synaptotagmin I | 2017 |
Akt Inhibitor Perifosine Prevents Epileptogenesis in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Neurons; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2018 |
Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy.
Topics: Animals; Antigens; Astrocytes; Cell Membrane; Connexin 30; Connexin 43; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Kainic Acid; Male; Mice; Mice, Transgenic; Platelet Endothelial Cell Adhesion Molecule-1; Proteoglycans; S100 Calcium Binding Protein beta Subunit; Subcellular Fractions; Up-Regulation | 2017 |
Establishment of a rhesus monkey model of chronic temporal lobe epilepsy using repetitive unilateral intra-amygdala kainic acid injections.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Gliosis; Infusion Pumps, Implantable; Kainic Acid; Macaca mulatta; Male; Neurosurgical Procedures; Pyramidal Cells; Seizures; Temporal Lobe | 2017 |
Wnt/β-catenin signalling pathway mediated aberrant hippocampal neurogenesis in kainic acid-induced epilepsy.
Topics: Animals; beta Catenin; Cyclin D1; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Up-Regulation; Wnt Signaling Pathway; Wnt3A Protein | 2017 |
POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Gene Knockdown Techniques; Hippocampus; Humans; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Ubiquitin-Protein Ligases; Young Adult | 2017 |
Anticonvulsant effect of gentamicin on the seizures induced by kainic acid.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gentamicins; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Valproic Acid | 2018 |
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Topics: Animals; Carbazoles; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorine Radioisotopes; Hippocampus; Kainic Acid; Male; Mice; Positron-Emission Tomography | 2018 |
The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Hippocampus; Kainic Acid; Learning Disabilities; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Plant Extracts; Rats; Rats, Wistar; Rosmarinus; Time Factors | 2018 |
Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Theta Rhythm | 2018 |
Electrophysiological Evidence for the Development of a Self-Sustained Large-Scale Epileptic Network in the Kainate Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; Cortical Excitability; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2018 |
Protective effect of compound Danshen (Salvia miltiorrhiza) dripping pills alone and in combination with carbamazepine on kainic acid-induced temporal lobe epilepsy and cognitive impairment in rats.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; CA3 Region, Hippocampal; Camphanes; Carbamazepine; Cognition; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy, Combination; Drugs, Chinese Herbal; Epilepsy, Temporal Lobe; Escape Reaction; Glial Cell Line-Derived Neurotrophic Factor; Kainic Acid; Male; Maze Learning; Panax notoginseng; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Reaction Time; Salvia miltiorrhiza; Time Factors | 2018 |
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model.
Topics: Administration, Oral; Animals; Anticonvulsants; Cannabidiol; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 2018 |
The role of the microRNA-146a/complement factor H/interleukin-1β-mediated inflammatory loop circuit in the perpetuate inflammation of chronic temporal lobe epilepsy.
Topics: Animals; Case-Control Studies; Cell Line; Chronic Disease; Complement Factor H; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Gene Knockdown Techniques; Hippocampus; Humans; Inflammation; Interleukin-1beta; Kainic Acid; Male; MicroRNAs; Rats, Sprague-Dawley; Up-Regulation | 2018 |
A single subconvulsant dose of domoic acid at mid-gestation does not cause temporal lobe epilepsy in mice.
Topics: Animals; Epilepsy, Temporal Lobe; Female; Gestational Age; Hippocampus; Kainic Acid; Marine Toxins; Mice; Pregnancy; Prenatal Exposure Delayed Effects | 2018 |
LncRNA H19 contributes to hippocampal glial cell activation via JAK/STAT signaling in a rat model of temporal lobe epilepsy.
Topics: Animals; Cytokines; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Janus Kinases; Kainic Acid; Male; Neuroglia; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Signal Transduction; STAT Transcription Factors; Transduction, Genetic | 2018 |
A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2019 |
Longitudinal positron emission tomography imaging of glial cell activation in a mouse model of mesial temporal lobe epilepsy: Toward identification of optimal treatment windows.
Topics: Animals; Autoradiography; CD11b Antigen; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluorodeoxyglucose F18; Glial Fibrillary Acidic Protein; In Vitro Techniques; Kainic Acid; Longitudinal Studies; Male; Mice; Mice, Inbred C57BL; Neuroglia; Platelet Endothelial Cell Adhesion Molecule-1; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Receptors, GABA; Statistics, Nonparametric; Time Factors; Tomography Scanners, X-Ray Computed | 2018 |
Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.
Topics: Acetylation; Animals; Disease Models, Animal; Energy Metabolism; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mitochondria; Mitochondrial Proteins; Rats; Rats, Sprague-Dawley; Sirtuins | 2018 |
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mefloquine; Mice; Nerve Tissue Proteins; Probenecid; Seizures; Signal Transduction | 2018 |
Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; Neuronal Plasticity; Seizures; Status Epilepticus | 2018 |
Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Fingolimod Hydrochloride; Kainic Acid; Male; Mice; Pilocarpine; Seizures | 2019 |
Correlation between tumor necrosis factor alpha mRNA and microRNA-155 expression in rat models and patients with temporal lobe epilepsy.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Gene Expression; Hippocampus; Humans; Kainic Acid; Male; MicroRNAs; Middle Aged; Random Allocation; Rats, Sprague-Dawley; RNA, Messenger; Specific Pathogen-Free Organisms; Status Epilepticus; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
Anterior nucleus of thalamus stimulation inhibited abnormal mossy fiber sprouting in kainic acid-induced epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cell Nucleus; Deep Brain Stimulation; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Seizures; Semaphorin-3A | 2018 |
Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses | 2018 |
Topics: Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Kainic Acid; Magnesium; Male; Memory Disorders; Mice; Mice, Inbred BALB C; Nerve Net; Prognosis; Random Allocation; Severity of Illness Index; Temporal Lobe; Treatment Outcome | 2018 |
The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Maze Learning; Mice, Inbred C57BL; Space Perception; Spatial Learning; Spatial Memory | 2019 |
Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets.
Topics: Animals; Anticonvulsants; Cell Death; Computational Biology; Computer Simulation; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; MicroRNAs; Neuroglia; Status Epilepticus | 2018 |
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Administration, Oral; Animals; Anticonvulsants; Citrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fruit; Hesperidin; Kainic Acid; Male; Mice; Phytotherapy | 2018 |
The Widespread Network Effects of Focal Epilepsy.
Topics: Animals; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Mice | 2018 |
Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis.
Topics: Animals; Astrocytes; Connexin 30; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Female; Kainic Acid; Luminescent Proteins; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Receptors, Purinergic P2Y1; Signal Transduction; Sodium Channel Blockers; Synapses; Tetrodotoxin; Tumor Necrosis Factor-alpha | 2018 |
A cynomolgus monkey model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Macaca fascicularis; Male; Seizures; Temporal Lobe | 2019 |
Gene Expression Profiling of Two Epilepsy Models Reveals the ECM/Integrin signaling Pathway is Involved in Epiletogenesis.
Topics: Animals; Databases, Genetic; Epilepsy, Temporal Lobe; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Regulatory Networks; Hippocampus; Humans; Integrins; Kainic Acid; Male; Meta-Analysis as Topic; Mice; Microarray Analysis; Pilocarpine; Rats; Signal Transduction | 2019 |
Acute Seizure Control Efficacy of Multi-Site Closed-Loop Stimulation in a Temporal Lobe Seizure Model.
Topics: Acute Disease; Algorithms; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Deep Brain Stimulation; Electric Stimulation; Epilepsy, Generalized; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Models, Neurological; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2019 |
Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.
Topics: Acetamides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lacosamide; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Signal Transduction; Status Epilepticus | 2019 |
Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.
Topics: Animals; Calcium Channels; Disease Models, Animal; Early Growth Response Protein 1; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Mice; Nerve Net; Pilocarpine; Seizures; Status Epilepticus | 2019 |
Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation.
Topics: Adult; Animals; Convulsants; Epilepsy, Temporal Lobe; Female; Humans; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; MicroRNAs; Seizures | 2019 |
Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Gyrus Cinguli; Hippocampus; Kainic Acid; Macaca mulatta; Magnetic Resonance Imaging; Male; Neurons; Neurosurgical Procedures; Robotic Surgical Procedures; Robotics; Seizures; Temporal Lobe | 2019 |
[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures | 2019 |
Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy.
Topics: Animals; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Random Allocation; Seizures; Ultrasonic Therapy | 2019 |
Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Hippocampus; Kainic Acid; Mice; Seizures; Synaptosomes | 2019 |
2-Deoxyglucose protects hippocampal neurons against kainate-induced temporal lobe epilepsy by modulating monocyte-derived macrophages (mo-MΦ) and progranulin production in the hippocampus.
Topics: Animals; Deoxyglucose; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Macrophages; Male; Neurons; Neuroprotective Agents; Progranulins; Rats, Wistar | 2019 |
Altered serotonin innervation in the rat epileptic brain.
Topics: Animals; Brain Stem; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Prosencephalon; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2019 |
Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools.
Topics: Animals; Cognitive Dysfunction; Discrimination Learning; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Maze Learning; Rats; Rats, Wistar; Recognition, Psychology; Reversal Learning; Spatial Memory | 2019 |
MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model of temporal lobe epilepsy.
Topics: Animals; Antagomirs; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Memory Disorders; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Spatial Memory; Status Epilepticus; Temporal Lobe | 2019 |
The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Pentylenetetrazole; Seizures | 2019 |
Ameliorative influence of Cnestis ferruginea vahl ex DC (Connaraceae) root extract on kainic acid-induced temporal lobe epilepsy in mice: Role of oxidative stress and neuroinflammation.
Topics: Animals; Anticonvulsants; Connaraceae; Cyclooxygenase 2; Epilepsy, Temporal Lobe; Hippocampus; Inflammation; Kainic Acid; Male; Medicine, African Traditional; Mice; NF-kappa B; Oxidative Stress; Plant Extracts; Plant Roots; Seizures | 2019 |
Subventricular zone-derived neural stem cell grafts protect against hippocampal degeneration and restore cognitive function in the mouse following intrahippocampal kainic acid administration.
Topics: Animals; Astrocytes; Behavior, Animal; Cell Movement; Cell Proliferation; Cell Survival; Cognition; Disease Models, Animal; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Insulin-Like Growth Factor I; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Neural Stem Cells; Neurogenesis; Neurons; Spheroids, Cellular; Time Factors; Transduction, Genetic | 2013 |
TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Adhesion Molecules, Neuronal; Dentate Gyrus; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Extracellular Matrix Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Matrix Metalloproteinases; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Proteolysis; Rats; Rats, Wistar; Recombinant Proteins; Reelin Protein; Serine Endopeptidases; Tissue Inhibitor of Metalloproteinase-1 | 2013 |
Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures.
Topics: Animals; Cell Death; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; HMGB1 Protein; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Neuropeptides; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Seizures; Toll-Like Receptor 4; Up-Regulation | 2013 |
Bupropion attenuates kainic acid-induced seizures and neuronal cell death in rat hippocampus.
Topics: Animals; Anticonvulsants; Bupropion; CA3 Region, Hippocampal; Cell Death; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Kainic Acid; Male; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Degeneration; Neurons; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Seizures | 2013 |
Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Motor Activity; Neurons; Receptor, trkB; Signal Transduction; Status Epilepticus | 2013 |
Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Receptors, N-Methyl-D-Aspartate; Seizures; Status Epilepticus; Transcription Factor AP-2 | 2013 |
GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice.
Topics: Animals; Autoreceptors; Baclofen; CA3 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA-B Receptor Agonists; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Models, Neurological; Nerve Net; Receptors, GABA-B | 2013 |
A macaque model of mesial temporal lobe epilepsy induced by unilateral intrahippocampal injection of kainic Acid.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Macaca; Magnetic Resonance Imaging; Male; Microscopy, Electron | 2013 |
Notch signaling activation promotes seizure activity in temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cells, Cultured; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Humans; Kainic Acid; Male; Mice, Inbred C57BL; Organ Culture Techniques; Receptor, Notch1; Seizures; Signal Transduction | 2014 |
Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Curcumin; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; Nitrites; Oxidative Stress; Rats; Rats, Wistar | 2013 |
Specific impairment of "what-where-when" episodic-like memory in experimental models of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Memory; Memory Disorders; Memory, Episodic; Rats; Rats, Wistar | 2013 |
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
Topics: Adenosine Triphosphate; alpha-Tocopherol; Animals; Ascorbic Acid; Disease Models, Animal; Electric Stimulation; Electroencephalography; Electron Transport Complex I; Epilepsy, Temporal Lobe; Hippocampus; Hydrogen Peroxide; In Vitro Techniques; Kainic Acid; Kv1.1 Potassium Channel; Mice; Mice, Knockout; Mitochondria; Pyruvic Acid; Reactive Oxygen Species; Respiration; Seizures | 2014 |
Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Coenzyme A; Epilepsy, Temporal Lobe; Glutathione; Glutathione Disulfide; Hippocampus; Kainic Acid; Male; Mitochondria; Neurons; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Seizures; Severity of Illness Index; Time Factors; Tyrosine | 2014 |
[Expression of growth-associated protein 43 in the hippocampus of mesial temporal lobe epilepsy mouse model].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Mice; Seizures | 2013 |
Treatment with melatonin after status epilepticus attenuates seizure activity and neuronal damage but does not prevent the disturbance in diurnal rhythms and behavioral alterations in spontaneously hypertensive rats in kainate model of temporal lobe epile
Topics: Animals; Antioxidants; Behavior, Animal; Blood Pressure; Body Weight; Brain; Circadian Rhythm; Disease Models, Animal; Epilepsy, Temporal Lobe; Exploratory Behavior; Food Preferences; Kainic Acid; Male; Maze Learning; Melatonin; Rats; Rats, Inbred SHR; Serotonin; Swimming; Time Factors | 2014 |
Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus).
Topics: Age Factors; Animals; Cell Count; Chronic Disease; Epilepsy; Epilepsy, Temporal Lobe; Female; Functional Laterality; Hippocampus; Humans; Kainic Acid; Male; Marine Toxins; Neurons; Organ Size; Sclerosis; Sea Lions; Sex Factors; Somatostatin; Species Specificity | 2014 |
Unexpected epilepsy model found in sea lions.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Sea Lions; Temporal Lobe; Water Pollutants, Chemical | 2014 |
Long-term modifications of epileptogenesis and hippocampal rhythms after prolonged hyperthermic seizures in the mouse.
Topics: Animals; Delta Rhythm; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electroencephalography; Epilepsy, Temporal Lobe; Female; Gamma Rhythm; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neuropeptides; Seizures, Febrile; Theta Rhythm | 2014 |
Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice.
Topics: Animals; Autoradiography; Disease Models, Animal; Epilepsy, Temporal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Kainic Acid; Male; Mice; Neocortex; Neuropeptide Y; Peptide YY; Receptors, Neuropeptide Y; RNA, Messenger; Seizures; Time Factors | 2014 |
Electroacupuncture at ST36-ST37 and at ear ameliorates hippocampal mossy fiber sprouting in kainic acid-induced epileptic seizure rats.
Topics: Acupuncture, Ear; Animals; Electroacupuncture; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mossy Fibers, Hippocampal; Neurons; Rats | 2014 |
Raloxifene protects against seizures and neurodegeneration in a mouse model mimicking epilepsy in postmenopausal woman.
Topics: Animals; Bone Density; Cyclohexenes; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Neurodegenerative Diseases; Neurons; Postmenopause; Raloxifene Hydrochloride; Seizures; Transforming Growth Factor beta3; Vinyl Compounds | 2014 |
Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.
Topics: Adenosine Kinase; Animals; Astrocytes; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Gene Targeting; Genetic Therapy; Genetic Vectors; Glutamate-Ammonia Ligase; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Transgenes | 2014 |
Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death.
Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Death; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Hippocampus; Kainic Acid; Male; Microglia; Neurons; Nootropic Agents; Pilocarpine; Rats; Rats, Sprague-Dawley | 2015 |
Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Epilepsy, Temporal Lobe; Kainic Acid; Losartan; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar; Treatment Outcome | 2014 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; Electroencephalography; Epilepsy, Temporal Lobe; Ethanol; Female; Kainic Acid; Mice; Nordazepam; Oxazepam; Seizures; Solvents; Temazepam; Water | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Levetiracetam; Mice; Phenobarbital; Phenytoin; Piracetam; Seizures; Valproic Acid | 2015 |
Neuroprotective and anti-inflammatory roles of the phosphatase and tensin homolog deleted on chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Animals; Anti-Inflammatory Agents; CA3 Region, Hippocampal; Cell Death; Disease Models, Animal; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Phosphoproteins; Protein Transport; PTEN Phosphohydrolase; Signal Transduction | 2014 |
Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy.
Topics: Acute Disease; Animals; Antioxidants; Cell Respiration; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Glycolysis; Hippocampus; Kainic Acid; Male; Mice, Knockout; Mitochondria; Oxygen; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 2015 |
Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Midazolam; Neural Inhibition; Neurons; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Mice; Nitriles; Phenytoin; Pyridones; Quinoxalines; Receptors, AMPA; Seizures; Status Epilepticus | 2015 |
Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: Underlying mechanisms.
Topics: Animals; Antioxidants; Cinnamates; Depsides; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Rosmarinic Acid | 2015 |
Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Seizures; Social Behavior; Status Epilepticus; Ultrasonography, Interventional | 2015 |
Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Animals; Apoptosis; CA3 Region, Hippocampal; Child; Child, Preschool; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Humans; Kainic Acid; Kindling, Neurologic; Male; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; RNA Interference; Seizures; Young Adult | 2015 |
TLR1 expression in mouse brain was increased in a KA-induced seizure model.
Topics: Animals; Astrocytes; Brain Chemistry; CA1 Region, Hippocampal; Dentate Gyrus; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Mice; Mice, Inbred C57BL; Microglia; Neurons; Polymerase Chain Reaction; RNA, Messenger; Seizures; Toll-Like Receptor 1; Up-Regulation | 2015 |
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
Topics: Animals; Cyclic N-Oxides; Epilepsy, Temporal Lobe; Hippocampus; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Kainic Acid; Lipopolysaccharides; Microglia; Nitrobenzenes; Oxidative Stress; Rats; Seizures; Spin Labels; Sulfonamides; Tumor Necrosis Factor-alpha | 2015 |
Metabolic changes in early poststatus epilepticus measured by MR spectroscopy in rats.
Topics: Animals; Antigens, Nuclear; Aspartic Acid; Brain Chemistry; Creatine; Epilepsy, Temporal Lobe; Glutamine; Inositol; Kainic Acid; Macrophage Activation; Magnetic Resonance Spectroscopy; Male; Nerve Tissue Proteins; Neuroglia; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2015 |
Cav3.1 T-type calcium channel modulates the epileptogenicity of hippocampal seizures in the kainic acid-induced temporal lobe epilepsy model.
Topics: Animals; Calcium Channels, T-Type; Cerebral Cortex; Delta Rhythm; Disease Models, Animal; Electrocorticography; Electrodes, Implanted; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Seizures; Status Epilepticus; Time Factors | 2015 |
Rapid brief feedback intracerebral stimulation based on real-time desynchronization detection preceding seizures stops the generation of convulsive paroxysms.
Topics: 4-Aminopyridine; Animals; CA1 Region, Hippocampal; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Neurofeedback; Potassium Channel Blockers; Rats; Seizures | 2015 |
GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis.
Topics: Adult; Aged; Aged, 80 and over; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA Agents; Hippocampus; Humans; Interleukin-1beta; Kainic Acid; Male; Middle Aged; Oocytes; Patch-Clamp Techniques; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Culture Techniques; Transplantation, Heterologous; Xenopus; Young Adult | 2015 |
Effects of eugenol on granule cell dispersion in a mouse model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; Eugenol; Hippocampus; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred C57BL; Multiprotein Complexes; Neurons; TOR Serine-Threonine Kinases | 2015 |
Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
Topics: Animals; Carbohydrate Sulfotransferases; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Net; Neurons; Parvalbumins; Plant Lectins; Receptors, N-Acetylglucosamine; Semaphorin-3A; Sulfotransferases; Time Factors | 2015 |
Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression Regulation; Histone Deacetylase 1; Histone Deacetylases; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Pilocarpine; Telemetry; Time Factors; Video Recording | 2015 |
Glycine transporter 1 is a target for the treatment of epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Dioxoles; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Glycine Plasma Membrane Transport Proteins; Hippocampus; Humans; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Rats, Sprague-Dawley; Seizures | 2015 |
The systemic kainic acid rat model of temporal lobe epilepsy: Long-term EEG monitoring.
Topics: Analysis of Variance; Animals; Brain; Brain Waves; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley | 2015 |
Protection against cognitive impairment and modification of epileptogenesis with curcumin in a post-status epilepticus model of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cognition Disorders; Curcumin; Disease Models, Animal; Encephalitis; Epilepsy, Temporal Lobe; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Rats; Rats, Wistar; Status Epilepticus; Tumor Necrosis Factor-alpha | 2015 |
Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy.
Topics: Animals; CA2 Region, Hippocampal; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluoresceins; Functional Laterality; Green Fluorescent Proteins; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Pyramidal Cells; RGS Proteins; Synaptophysin; Time Factors | 2016 |
Evolution of temporal and spectral dynamics of pathologic high-frequency oscillations (pHFOs) during epileptogenesis.
Topics: Animals; CA1 Region, Hippocampal; Convulsants; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Status Epilepticus | 2015 |
Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.
Topics: Animals; Cerebral Cortex; Dependovirus; Electroencephalography; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Translational Research, Biomedical | 2016 |
Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals.
Topics: Animals; Calbindins; Cell Adhesion Molecules, Neuronal; Cholecystokinin; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Extracellular Matrix Proteins; Female; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Male; Miniature Postsynaptic Potentials; Nerve Tissue Proteins; Neural Pathways; Parvalbumins; Presynaptic Terminals; Rats, Wistar; Reelin Protein; Serine Endopeptidases; Tissue Culture Techniques | 2016 |
Significant effects of sex, strain, and anesthesia in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Anesthesia; Anesthetics; Animals; Chloral Hydrate; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Isoflurane; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microinjections; Sex Characteristics; Species Specificity; Status Epilepticus | 2016 |
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures.
Topics: Animals; Astrocytes; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Metabotropic Glutamate 5; Seizures; Status Epilepticus | 2016 |
Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fourier Analysis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures; Time Factors; Treatment Outcome | 2016 |
The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation.
Topics: Animals; Antibodies; Benzoxazines; Chemokine CCL2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Indazoles; Inflammation; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Piperidines; Propionates; Receptors, CCR2; RNA, Messenger; Signal Transduction; Up-Regulation | 2016 |
Leukocyte Infiltration Triggers Seizure Recurrence in a Rat Model of Temporal Lobe Epilepsy.
Topics: Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Inflammation; Kainic Acid; Leukocytes; Neurons; Rats; Recurrence; Seizures | 2016 |
Naringin attenuates granule cell dispersion in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Carrier Proteins; Cell Cycle Proteins; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Eukaryotic Initiation Factors; Flavanones; Flavonoids; Humans; Injections, Intraperitoneal; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Neurons; Phosphoproteins | 2016 |
High-Throughput LC-MS/MS Proteomic Analysis of a Mouse Model of Mesiotemporal Lobe Epilepsy Predicts Microglial Activation Underlying Disease Development.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; High-Throughput Screening Assays; Kainic Acid; Mice; Microglia; Neurodegenerative Diseases; Proteome; Proteomics; Synaptic Transmission; Tandem Mass Spectrometry; Time Factors | 2016 |
Synaptic Remodeling of Entorhinal Input Contributes to an Aberrant Hippocampal Network in Temporal Lobe Epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Neuronal Plasticity; Synapses; Tissue Culture Techniques | 2017 |
Confounding effect of EEG implantation surgery: Inadequacy of surgical control in a two hit model of temporal lobe epilepsy.
Topics: Animals; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Hyperthermia, Induced; Inflammation; Kainic Acid; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Transgenic; Microglia | 2016 |
Non-parametric directionality analysis - Extension for removal of a single common predictor and application to time series.
Topics: Action Potentials; Algorithms; Animals; Cerebral Cortex; Computer Simulation; Data Interpretation, Statistical; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Models, Neurological; Multivariate Analysis; Neurons; Rats; Signal Processing, Computer-Assisted; Software; Time Factors | 2016 |
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Topics: Adenosine Triphosphate; Adult; Animals; Apoptosis; CX3C Chemokine Receptor 1; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Leukocyte Common Antigens; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Monocytes; Neurons; Phagocytosis; Receptors, CCR2; Receptors, Chemokine; Seizures | 2016 |
Knockout of P-glycoprotein does not alter antiepileptic drug efficacy in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Action Potentials; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; CA1 Region, Hippocampal; Drug Resistance; Epilepsy, Temporal Lobe; Female; Kainic Acid; Mice; Mice, Knockout; Treatment Outcome | 2016 |
Expressions of CCAAT/enhancer-binding Protein Homologous Protein and Calnexin in the Hippocampus of a Mouse Model of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Calnexin; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Seizures; Transcription Factor CHOP | 2016 |
The ability of anterior thalamic signals to predict seizures in temporal lobe epilepsy in kainate-treated rats.
Topics: Algorithms; Animals; Anterior Thalamic Nuclei; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Wistar; Seizures; Time Factors | 2016 |
Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Status Epilepticus | 2016 |
Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats.
Topics: Acute Disease; Amino Acids; Animals; Autoradiography; Chronic Disease; Cross-Sectional Studies; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Male; Parietal Lobe; Radiopharmaceuticals; Rats, Wistar; Receptors, Metabotropic Glutamate; Thalamus; Time Factors; Tritium; Xanthenes | 2016 |
Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticonvulsants; Carrier Proteins; Cell Cycle Proteins; Cytokines; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Eukaryotic Initiation Factors; Excitatory Amino Acid Agonists; Flavanones; Kainic Acid; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Phosphoproteins | 2016 |
Isoflurane prevents acquired epilepsy in rat models of temporal lobe epilepsy.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Electrocorticography; Epilepsy, Temporal Lobe; Female; Inflammation; Isoflurane; Kainic Acid; Magnetic Resonance Imaging; Male; Neuroimaging; Neurons; Paraoxon; Positron-Emission Tomography; Rats | 2016 |
Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Topics: Animals; Astrocytes; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Status Epilepticus; Time Factors | 2016 |
Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis.
Topics: Aldehydes; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Ketones; Male; Memory Disorders; Neuroprotective Agents; Pilocarpine; Random Allocation; Rats, Sprague-Dawley; Salicylanilides; Status Epilepticus | 2017 |
Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy.
Topics: Animals; Cerebral Cortex; Connectome; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Limbic System; Male; Nerve Net; Rats; Rats, Long-Evans | 2017 |
CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Benzylamines; Chemokine CXCL12; Cognition Disorders; Cyclams; Disease Models, Animal; Epilepsy, Temporal Lobe; Heterocyclic Compounds; Hippocampus; Housing, Animal; Kainic Acid; Male; Neurogenesis; Neurons; Random Allocation; Rats, Wistar; Receptors, CXCR4; Seizures | 2017 |
A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Humans; Kainic Acid; Lorazepam; Male; Mossy Fibers, Hippocampal; Neurodegenerative Diseases; Rats; Rats, Sprague-Dawley; Sclerosis; Video Recording | 2017 |
Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; GluK2 Kainate Receptor; Glutamic Acid; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Kainic Acid; Resveratrol; Stilbenes; Up-Regulation | 2017 |
Various modifications of the intrahippocampal kainate model of mesial temporal lobe epilepsy in rats fail to resolve the marked rat-to-mouse differences in type and frequency of spontaneous seizures in this model.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Rats; Seizures; Species Specificity; Status Epilepticus | 2017 |
Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.
Topics: Animals; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gamma Rhythm; Hippocampus; Interneurons; Kainic Acid; Kallikreins; Long-Term Potentiation; Male; Mice; Mice, Knockout; Neuregulin-1; Parvalbumins; Pyramidal Cells; Receptor, ErbB-4; Signal Transduction; Status Epilepticus | 2017 |
Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death.
Topics: Analysis of Variance; Animals; Benzoquinones; Carbazoles; Cell Death; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Indole Alkaloids; Kainic Acid; Lactams, Macrocyclic; Limbic System; Male; Mossy Fibers, Hippocampal; Nerve Growth Factors; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Rifabutin; Seizures; Statistics, Nonparametric | 2008 |
Grafting of striatal precursor cells into hippocampus shortly after status epilepticus restrains chronic temporal lobe epilepsy.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Disease Progression; Embryo, Mammalian; Epilepsy, Temporal Lobe; Fibroblast Growth Factor 2; Hippocampus; Kainic Acid; Nerve Tissue Proteins; Neurons; Neuropeptide Y; Rats; Rats, Inbred F344; Status Epilepticus; Stem Cell Transplantation; Stem Cells; Time Factors | 2008 |
Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate.
Topics: Animals; Convulsants; Dentate Gyrus; Depressive Disorder; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Learning Disabilities; Maze Learning; Memory Disorders; Mental Disorders; Mice; Mood Disorders; Nerve Degeneration; Neurocognitive Disorders; Neuropsychological Tests; Status Epilepticus | 2008 |
Intra-amygdaloid injection of kainic acid in rats with genetic absence epilepsy: the relationship of typical absence epilepsy and temporal lobe epilepsy.
Topics: Amygdala; Animals; Electroencephalography; Epilepsy, Absence; Epilepsy, Temporal Lobe; Kainic Acid; Male; Rats; Rats, Wistar | 2008 |
Thalamic pathology in sudden cardiac death in epilepsy: a shed light on mysterious event.
Topics: Animals; Brain; Death, Sudden, Cardiac; Disease Models, Animal; Epilepsy, Temporal Lobe; Heart Arrest; Humans; Ibotenic Acid; Kainic Acid; Magnetic Resonance Imaging; Oxygen Consumption; Pilocarpine; Rats; Thalamic Nuclei | 2008 |
Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microglia; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Inbred F344; Seizures; Status Epilepticus; Thalamus | 2008 |
Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Anti-Dyskinesia Agents; Botulinum Toxins; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2009 |
Contribution of nitric oxide, superoxide anion, and peroxynitrite to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus.
Topics: Analysis of Variance; Animals; Apoptosis; Caspase 3; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Electron Transport Complex III; Enzyme Activation; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mitochondria; NAD; Nitric Oxide; Peroxynitrous Acid; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Time Factors; Ubiquinone | 2009 |
Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blotting, Western; Cell Death; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Wistar; Receptors, Kainic Acid; Resveratrol; Seizures; Stilbenes | 2009 |
Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cell Differentiation; Cell Survival; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Microglia; Neurogenesis; Neurons; Oligodendroglia; Rats; Rats, Inbred F344; Stem Cell Niche; Stem Cells; Time Factors | 2010 |
Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat.
Topics: Animals; Cerebral Cortex; Circadian Rhythm; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors; Video Recording | 2009 |
Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Hypnotics and Sedatives; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Microdialysis; Midazolam; Mossy Fibers, Hippocampal; Synapsins; Time Factors; Vesicular Glutamate Transport Protein 1; Zinc | 2009 |
Alterations of NR2B and PSD-95 expression in hippocampus of kainic acid-exposed rats with behavioural deficits.
Topics: Animals; Disks Large Homolog 4 Protein; Epilepsy, Temporal Lobe; Exploratory Behavior; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Maze Learning; Membrane Proteins; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spatial Behavior; Status Epilepticus | 2009 |
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Fluoresceins; Gene Expression Regulation; Immunosuppressive Agents; In Situ Nick-End Labeling; Kainic Acid; Male; Mossy Fibers, Hippocampal; Organic Chemicals; Protein Kinases; Rats; Rats, Sprague-Dawley; Seizures; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Video Recording | 2009 |
Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways.
Topics: Animals; Behavior, Animal; Cluster Analysis; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Histocytochemistry; Inflammation; Kainic Acid; Male; Nerve Degeneration; Neuronal Plasticity; Rats; Rats, Inbred F344; Reproducibility of Results; Signal Transduction; Toxicogenetics | 2009 |
Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat.
Topics: Animals; Biomarkers; Cell Death; Cytoprotection; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluoresceins; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; HSP72 Heat-Shock Proteins; Insulin-Like Growth Factor I; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organic Chemicals; Rats; Rats, Wistar; Staining and Labeling; Stress, Physiological | 2010 |
Environmental risk factors for temporal lobe epilepsy--is prenatal exposure to the marine algal neurotoxin domoic acid a potentially preventable cause?
Topics: Adult; Animals; Environmental Exposure; Epilepsy, Temporal Lobe; Eukaryota; Female; Food Contamination; Humans; Kainic Acid; Marine Toxins; Models, Biological; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment | 2010 |
A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity.
Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Intercellular Signaling Peptides and Proteins; Kainic Acid; Male; Metallothionein; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Peptides; Rats; Rats, Wistar; Seizures | 2010 |
Timed changes of synaptic zinc, synaptophysin and MAP2 in medial extended amygdala of epileptic animals are suggestive of reactive neuroplasticity.
Topics: Amygdala; Animals; Biomarkers; Convulsants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Growth Cones; Histocytochemistry; Immunohistochemistry; Kainic Acid; Male; Microtubule-Associated Proteins; Neuronal Plasticity; Presynaptic Terminals; Rats; Rats, Wistar; Septal Nuclei; Staining and Labeling; Synaptophysin; Zinc | 2010 |
Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus.
Topics: Actins; Animals; Dependovirus; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Hippocampus; Immunity, Humoral; Kainic Acid; Learning; Male; Memory; Motor Activity; Neuropeptide Y; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Seizures; Transduction, Genetic | 2010 |
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Injections, Intraventricular; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Midkine; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Pyramidal Cells | 2010 |
PSA-NCAM-dependent GDNF signaling limits neurodegeneration and epileptogenesis in temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Focal Adhesion Protein-Tyrosine Kinases; Glial Cell Line-Derived Neurotrophic Factor; Glycoside Hydrolases; Hippocampus; Kainic Acid; Male; Mice; Nerve Degeneration; Neural Cell Adhesion Molecule L1; Neuroprotective Agents; Sialic Acids; Signal Transduction | 2010 |
Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures.
Topics: Adenosine; Animals; Anticonvulsants; Catheterization; Disease Models, Animal; Drug Delivery Systems; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 2010 |
Congenic strains provide evidence that a mapped locus on chromosome 15 influences excitotoxic cell death.
Topics: Animals; Behavior, Animal; Cell Count; Cell Death; Chromosome Mapping; Chromosomes, Mammalian; DNA; Epilepsy, Temporal Lobe; Genotype; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Mice, Congenic; Mice, Inbred C57BL; Microsatellite Repeats; Neurons; Phenotype; Seizures | 2011 |
Changes in hippocampal GABAA/cBZR density during limbic epileptogenesis: relationship to cell loss and mossy fibre sprouting.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Neuronal Plasticity; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Recovery of Function; Status Epilepticus | 2011 |
Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy.
Topics: Animals; Botulinum Toxins; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calbindin 2; Cell Adhesion Molecules, Neuronal; Cell Count; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Extracellular Matrix Proteins; Hippocampus; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Tissue Proteins; Receptor, trkB; Reelin Protein; S100 Calcium Binding Protein G; Serine Endopeptidases; Synaptic Transmission | 2011 |
Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Neurons; Neurosurgical Procedures; Seizures | 2011 |
Suppression of hippocampal epileptic seizures in the kainate rat by Poisson distributed stimulation.
Topics: Animals; Brain Mapping; Deep Brain Stimulation; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Poisson Distribution; Rats; Rats, Wistar; Signal Processing, Computer-Assisted; Status Epilepticus | 2010 |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
Topics: Aminopeptidases; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Lectins, C-Type; Male; Neurotoxins; Pancreatitis-Associated Proteins; Rats; Rats, Wistar; Seizures; Temporal Lobe | 2011 |
Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Computer Simulation; Disease Models, Animal; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Models, Biological; Time Factors | 2010 |
Chronic electrographic seizure reduces glutamine and elevates glutamate in the extracellular fluid of rat brain.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Extracellular Fluid; Glutamic Acid; Glutamine; Hippocampus; Intracellular Fluid; Kainic Acid; Male; Microdialysis; Neurotoxins; Rats; Rats, Wistar; Synaptic Vesicles | 2011 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Agonists; Hippocampus; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Muscimol; N-Methylaspartate; Neurons; Statistics, Nonparametric; Time Factors; Wakefulness | 2010 |
Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Catecholamines; Chromatography, High Pressure Liquid; Chronobiology Disorders; Circadian Rhythm; Depression; Disease Models, Animal; Epilepsy, Temporal Lobe; Escape Reaction; Hippocampus; Kainic Acid; Male; Maze Learning; Rats; Rats, Inbred SHR; Rats, Wistar; Statistics, Nonparametric; Sucrose; Swimming; Time Factors | 2011 |
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.
Topics: Adaptive Immunity; Analysis of Variance; Animals; Biomarkers; Brain; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Immunity, Innate; Immunohistochemistry; Intercellular Adhesion Molecule-1; Kainic Acid; Leukocyte Common Antigens; Leukocyte Count; Leukocytes; Male; Mice; Mice, Knockout; Microglia; Neurons; Sclerosis | 2011 |
The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.
Topics: Actins; Analysis of Variance; Animals; Antibodies, Neutralizing; Astrocytes; Dependovirus; Epilepsy, Temporal Lobe; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; Immunohistochemistry; Kainic Acid; Male; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Transduction, Genetic | 2011 |
Reduced astrocytic contribution to the turnover of glutamate, glutamine, and GABA characterizes the latent phase in the kainate model of temporal lobe epilepsy.
Topics: Amino Acids; Animals; Astrocytes; Carbon Isotopes; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isotope Labeling; Kainic Acid; Magnetic Resonance Spectroscopy; Rats; Transaminases | 2011 |
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Functional Laterality; Hippocampus; Kainic Acid; Luminescent Proteins; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; Neurogenesis; Neuropeptides; Patch-Clamp Techniques; Picrotoxin | 2012 |
Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.
Topics: Animals; Calbindin 2; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Functional Laterality; Gene Expression Regulation; Hippocampus; Indoles; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphotransferases; Receptors, AMPA; S100 Calcium Binding Protein G; Stereotaxic Techniques; Synaptophysin | 2011 |
IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Insulin-Like Growth Factor I; Kainic Acid; Male; Maze Learning; Memory; Mice; Nerve Degeneration; Neurogenesis; Neurons | 2011 |
Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Learning; Magnetic Resonance Imaging; Male; Maze Learning; Memory Disorders; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spatial Behavior | 2011 |
Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Channelopathies; Chromatin; Cyclic Nucleotide-Gated Cation Channels; Dendrites; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channel Gating; Kainic Acid; Male; Nucleotides, Cyclic; Potassium Channels; Rats; Rats, Wistar; Repressor Proteins; Status Epilepticus | 2011 |
Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy.
Topics: Animals; Anticholesteremic Agents; Behavior, Animal; Chronic Disease; Cytokines; Enzyme-Linked Immunosorbent Assay; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Wistar; Simvastatin; Status Epilepticus | 2011 |
Functional changes in the septal GABAergic system of animals with a model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Kainic Acid; Models, Biological; Neurons; Oscillometry; Receptors, GABA-A; Receptors, GABA-B | 2011 |
Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Eicosanoids; Epilepsy, Temporal Lobe; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Plant Lectins; RNA, Messenger; Seizures; Signal Transduction; Time Factors | 2011 |
Epileptic seizure detection with the local field potential of anterior thalamic of rats aiming at real time application.
Topics: Algorithms; Animals; Deep Brain Stimulation; Disease Models, Animal; Electric Power Supplies; Electrodes; Electroencephalography; Epilepsy, Temporal Lobe; Equipment and Supplies; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures; Thalamus | 2011 |
Synchrony dynamics across brain structures in limbic epilepsy vary between initiation and termination phases of seizures.
Topics: Animals; Electrophysiological Phenomena; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Models, Neurological; Rats; Rats, Sprague-Dawley; Seizures; Signal Processing, Computer-Assisted | 2013 |
Do proconvulsants modify or halt epileptogenesis? Pentylenetetrazole is ineffective in two rat models of temporal lobe epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; GABA-A Receptor Agonists; Kainic Acid; Lithium; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2012 |
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.
Topics: Adult; Animals; CA3 Region, Hippocampal; Cell Death; Dendritic Spines; Epilepsy, Temporal Lobe; Gene Silencing; Humans; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Neurons; Neuroprotective Agents; Pyramidal Cells; Real-Time Polymerase Chain Reaction; Recurrence; Seizures; Status Epilepticus; Up-Regulation | 2012 |
Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE.
Topics: Analysis of Variance; Animals; Atrophy; Brain Mapping; CA1 Region, Hippocampal; Disease Models, Animal; Disease Progression; Electroencephalography; Electron Transport Complex IV; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fluorodeoxyglucose F18; Glial Fibrillary Acidic Protein; Glucose Metabolism Disorders; Glucose Transporter Type 1; Kainic Acid; Limbic System; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Pyramidal Cells; Rats; Rats, Wistar; Synaptophysin; Time Factors | 2012 |
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.
Topics: Animals; Anticonvulsants; Astrocytes; Diazepam; Disease Models, Animal; Drug Resistance; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Marine Toxins; Microglia; Nerve Degeneration; Neurogenesis; Neurons; Organ Specificity; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Status Epilepticus; Time Factors | 2012 |
Mapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsy.
Topics: Adult; Animals; Astrocytes; Case-Control Studies; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Immunoenzyme Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Middle Aged; Neurons; Sclerosis; Seizures; Signal Transduction; TOR Serine-Threonine Kinases; Young Adult | 2012 |
Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus.
Topics: Adult Stem Cells; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Proliferation; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression; Genes, Reporter; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Notch1; Repressor Proteins; Signal Transduction; SOXB1 Transcription Factors; Status Epilepticus; Stem Cell Niche | 2012 |
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy.
Topics: 4-Aminopyridine; Animals; Cyclosporine; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Recurrence; Seizures | 2012 |
A guinea pig model of mesial temporal lobe epilepsy following nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Guinea Pigs; Hippocampus; Kainic Acid; Male; Status Epilepticus | 2012 |
Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Malondialdehyde; Mossy Fibers, Hippocampal; Neuroprotective Agents; Nitrites; Oxidative Stress; Rats; Status Epilepticus; Ubiquinone; Vitamins | 2013 |
The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Hyperkinesis; Kainic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2013 |
Manganese-enhanced MRI reflects seizure outcome in a model for mesial temporal lobe epilepsy.
Topics: Animals; Contrast Media; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Image Interpretation, Computer-Assisted; Kainic Acid; Magnetic Resonance Imaging; Male; Manganese; Rats; Rats, Wistar; Seizures | 2013 |
Urokinase-type plasminogen activator receptor modulates epileptogenesis in mouse model of temporal lobe epilepsy.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Body Temperature; Cell Movement; Dentate Gyrus; Disease Models, Animal; Doublecortin Domain Proteins; Epilepsy, Temporal Lobe; Genotype; Inflammation; Kainic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mossy Fibers, Hippocampal; Nerve Degeneration; Neurogenesis; Neuropeptides; Receptors, Urokinase Plasminogen Activator; Status Epilepticus; Survival Analysis; T-Lymphocytes | 2013 |
Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy.
Topics: Animals; Aquaporin 4; Astrocytes; Cell Polarity; Chronic Disease; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2013 |
Relations between brain pathology and temporal lobe epilepsy.
Topics: Animals; Brain; Cell Death; Cell Survival; Chronic Disease; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Kainic Acid; Limbic System; Male; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Rats; Rats, Inbred F344; Rats, Wistar; Reaction Time; Recurrence; Survival Rate | 2002 |
Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Ibotenic Acid; Injections; Kainic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Entorhinal axons exhibit sprouting in CA1 subfield of the adult hippocampus in a rat model of temporal lobe epilepsy.
Topics: Animals; Axons; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Nerve Regeneration; Rats; Rats, Inbred F344; Reference Values | 2002 |
Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Chemistry; Disease Models, Animal; Endothelium, Vascular; Epilepsy, Temporal Lobe; Female; Hippocampus; Immunohistochemistry; Kainic Acid; Limbic System; Rats; Time Factors | 2002 |
Synaptotagmin I hypothalamic knockdown prevents amygdaloid seizure-induced damage of hippocampal neurons but not of entorhinal neurons.
Topics: Amygdala; Animals; Calcium-Binding Proteins; Disease Models, Animal; Down-Regulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Hypothalamus; Kainic Acid; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Neural Pathways; Neurons; Oligonucleotides, Antisense; Rats; Rats, Wistar; Synaptic Transmission; Synaptotagmin I; Synaptotagmins | 2002 |
Increased dendritic excitability in hippocampal ca1 in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis.
Topics: Action Potentials; Animals; Bicuculline; Dendrites; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Kainic Acid; Male; Neural Inhibition; Neural Pathways; Perforant Pathway; Rats; Rats, Long-Evans; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2003 |
N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy.
Topics: Animals; Cell Death; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; DNA Fragmentation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Limbic System; Mediodorsal Thalamic Nucleus; Nerve Degeneration; Neurons; Neuroprotective Agents; Olfactory Pathways; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus; Treatment Outcome | 2003 |
Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures.
Topics: Animals; Animals, Newborn; Cell Death; Cell Division; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Membrane Potentials; Mossy Fibers, Hippocampal; Neural Pathways; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Seizures, Febrile; Synaptic Transmission | 2003 |
Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Injections; Kainic Acid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Temporal Lobe | 2003 |
Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Disease Progression; Down-Regulation; Dynorphins; Enkephalins; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Opioid Peptides; Rats; Rats, Wistar; Reaction Time; Status Epilepticus | 2003 |
Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor-2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Division; Disease Models, Animal; Epilepsy, Temporal Lobe; Fetus; Fibroblast Growth Factor 2; Graft Survival; Hippocampus; Kainic Acid; Male; Memory Disorders; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Phenotype; Rats; Rats, Inbred F344; Stem Cells | 2003 |
Pretreatment of donor cells with FGF-2 enhances survival of fetal hippocampal CA3 cell transplants in the chronically lesioned young adult hippocampus.
Topics: Animals; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Count; Cell Survival; Cells, Cultured; Chronic Disease; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Fibroblast Growth Factor 2; Graft Survival; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Inbred F344 | 2003 |
Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Growth Factor; Nerve Growth Factors; Neurotrophin 3; Rats; Rats, Inbred F344 | 2003 |
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Topics: Animals; Carrier Proteins; Cell Membrane; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mossy Fibers, Hippocampal; Neurons; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2003 |
Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Neuropeptide Y; Receptors, GABA-B; Somatostatin; Time; Time Factors | 2003 |
Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice.
Topics: Action Potentials; Animals; Causality; Cell Membrane; Disease Models, Animal; Disease Susceptibility; Electric Impedance; Encephalitis, Herpes Simplex; Epilepsy; Epilepsy, Temporal Lobe; Herpesvirus 1, Human; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Neural Pathways; Organ Culture Techniques; Pyramidal Cells; Viral Proteins | 2003 |
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis.
Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Anticonvulsants; Astrocytes; Brain; Disease Models, Animal; Disease Progression; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Mice; Neurons; Tubercidin; Xanthines | 2004 |
Enhancement of central dopaminergic activity in the kainate model of temporal lobe epilepsy: implication for the mechanism of epileptic psychosis.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Electrochemistry; Epilepsy, Temporal Lobe; Haloperidol; In Vitro Techniques; Kainic Acid; Male; Methamphetamine; Microdialysis; Motor Activity; Psychotic Disorders; Rats; Rats, Sprague-Dawley | 2004 |
Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy.
Topics: Acute Disease; Animals; Chronic Disease; Convulsants; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Antagonists; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapses | 2004 |
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; GAP-43 Protein; Growth Cones; Hyaluronan Receptors; Immunohistochemistry; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Nerve Degeneration; Neuronal Plasticity; Neuropeptide Y; Pilocarpine; Status Epilepticus; Up-Regulation | 2004 |
Contributions of mossy fiber and CA1 pyramidal cell sprouting to dentate granule cell hyperexcitability in kainic acid-treated hippocampal slice cultures.
Topics: Animals; Axons; Buffers; Cell Shape; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Mossy Fibers, Hippocampal; Organ Culture Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2004 |
Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus.
Topics: Animals; Astrocytes; Calcium-Transporting ATPases; Cation Transport Proteins; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Plasma Membrane Calcium-Transporting ATPases; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Status Epilepticus; Up-Regulation | 2004 |
Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat.
Topics: Animals; Disease Models, Animal; Electroencephalography; Electron Transport Complex I; Electron Transport Complex III; Electron Transport Complex IV; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mitochondria; Mitochondrial Diseases; Neurons; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2004 |
Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Benzodiazepines; Cell Count; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; GABA Modulators; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Midazolam; Mossy Fibers, Hippocampal; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2005 |
Phospholipase D1-promoted release of tissue plasminogen activator facilitates neurite outgrowth.
Topics: Animals; Brain; Cells, Cultured; Convulsants; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mossy Fibers, Hippocampal; Neurites; Neurons; Phospholipase D; Recombinant Fusion Proteins; Sindbis Virus; Tissue Plasminogen Activator; Transfection | 2005 |
Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus.
Topics: Action Potentials; Animals; Brain Chemistry; Calbindins; Chronic Disease; Disease Models, Animal; Down-Regulation; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Galanin; Hippocampus; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Nerve Degeneration; Neural Pathways; Neuropeptide Y; Neurotoxins; Pyramidal Cells; S100 Calcium Binding Protein G; Sincalide; Status Epilepticus; Theta Rhythm; Up-Regulation | 2005 |
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Topics: Adenosine Kinase; Animals; Astrocytes; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Locomotion; Male; Mice; Mice, Transgenic; Neurons; Transgenes; Tubercidin; Up-Regulation | 2005 |
Short-term effects of kainic acid on CA1 hippocampal interneurons differentially vulnerable to excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; In Vitro Techniques; Interneurons; Kainic Acid; Male; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Somatostatin; Tetrodotoxin | 2005 |
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors.
Topics: Animals; Cells, Cultured; Convulsants; Cyclohexanes; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurons; Neuropeptide Y; Organ Culture Techniques; Receptors, Neuropeptide Y; Synaptic Transmission; Xanthenes | 2005 |
Behavioral and histopathological analysis of domoic Acid administration in marmosets.
Topics: Animals; Behavior, Animal; Brain; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Female; Follow-Up Studies; Injections, Intraperitoneal; Kainic Acid; Male; Motor Activity; Neurotoxicity Syndromes; Status Epilepticus | 2005 |
Central-type benzodiazepine receptors and epileptogenesis: basic mechanisms and clinical validity.
Topics: Adult; Amygdala; Animals; Autoradiography; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Epilepsies, Partial; Epilepsy, Temporal Lobe; Female; Flumazenil; Hippocampus; Humans; Iodine Radioisotopes; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Neocortex; Rats; Receptors, GABA-A; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon | 2005 |
Effects of neurotransmitter agonists on electrocortical activity in the rat kainate model of temporal lobe epilepsy and the modulatory action of basic fibroblast growth factor.
Topics: Animals; Baclofen; Clonidine; Electroencephalography; Epilepsy, Temporal Lobe; Fibroblast Growth Factor 2; Functional Laterality; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Muscimol; N-Methylaspartate; Nerve Net; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Signal Transduction; Somatosensory Cortex | 2005 |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats.
Topics: Adenosine; Animals; Caffeine; Coffea; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Epilepsy, Temporal Lobe; Kainic Acid; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Substance Withdrawal Syndrome | 2005 |
Repair of the injured adult hippocampus through graft-mediated modulation of the plasticity of the dentate gyrus in a rat model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neuronal Plasticity; Pyramidal Cells; Rats; Rats, Inbred F344; Transplantation, Homologous | 2005 |
Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cell Survival; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Male; Mice; Neurons; Phosphopyruvate Hydratase; Seizures; Time Factors | 2005 |
Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspases; Cytochromes c; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Minocycline; Neuroprotective Agents | 2006 |
Hippocampal neurodegeneration, spontaneous seizures, and mossy fiber sprouting in the F344 rat model of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Fluoresceins; Forelimb; Functional Laterality; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neuropeptide Y; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Inbred F344; Seizures; Silver Staining; Time Factors | 2006 |
Impairment of dentate gyrus neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Differentiation; Disease Models, Animal; Doublecortin Domain Proteins; Epilepsy, Temporal Lobe; Functional Laterality; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Microtubule-Associated Proteins; Neurons; Neuropeptides; Proliferating Cell Nuclear Antigen; Stem Cells; Time Factors | 2006 |
Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Conditioning, Classical; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy; Epilepsy, Temporal Lobe; Fear; Freezing Reaction, Cataleptic; Kainic Acid; Male; Motor Activity; Rats; Rats, Wistar; Status Epilepticus; Videotape Recording | 2006 |
Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation.
Topics: Animals; Benzodiazepines; Cell Death; Chelating Agents; Disease Models, Animal; Ditiocarb; Dizocilpine Maleate; Epilepsy, Temporal Lobe; Hippocampus; HSP72 Heat-Shock Proteins; Kainic Acid; Male; Mice; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Zinc | 2006 |
Beneficial effects of FK506 for experimental temporal lobe epilepsy.
Topics: Aggression; Animals; Anticonvulsants; Cell Survival; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Immunosuppressive Agents; In Situ Nick-End Labeling; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Tacrolimus; Trimethyltin Compounds | 2006 |
Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures.
Topics: Animals; Animals, Newborn; Benzothiadiazines; Cells, Cultured; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Kainic Acid; Membrane Potentials; Neural Inhibition; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses | 2006 |
Changes in lipid composition in hippocampus early and late after status epilepticus induced by kainic acid in wistar rats.
Topics: Animals; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Lipid Metabolism; Lipid Peroxidation; Male; Membrane Fluidity; Oxidative Stress; Rats; Rats, Wistar; Status Epilepticus | 2007 |
Rats bred for susceptibility to depression-like phenotypes have higher kainic acid-induced seizure mortality than their depression-resistant counterparts.
Topics: Animals; Convulsants; Depression; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Flurothyl; Kainic Acid; Male; Phenotype; Rats; Rats, Sprague-Dawley; Seizures; Stress, Psychological | 2007 |
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kainic Acid; Lithium Compounds; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Sclerosis; Wnt Proteins | 2007 |
A quantitative trait locus on chromosome 18 is a critical determinant of excitotoxic cell death susceptibility.
Topics: Animals; Brain; Cell Death; Chromosomes, Mammalian; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Humans; Kainic Acid; Male; Mice; Mice, Congenic; Neurons; Phenotype; Quantitative Trait Loci; Seizures | 2007 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Flumazenil; Injections, Intraperitoneal; Kainic Acid; Midazolam; Rats; Receptors, GABA-A; Status Epilepticus; Treatment Outcome; Tritium | 2007 |
Restoration of calbindin after fetal hippocampal CA3 cell grafting into the injured hippocampus in a rat model of temporal lobe epilepsy.
Topics: Animals; Calbindins; Cell Count; Disease Models, Animal; Embryo, Mammalian; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Inbred F344; S100 Calcium Binding Protein G | 2007 |
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Topics: Adult; Aged; Animals; Apoptosis; Caspase 2; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; Models, Animal; Neurons; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
Multiparametric MRI evaluation of kainic acid-induced neuronal activation in rat hippocampus.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Mapping; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gadolinium DTPA; Hippocampus; Kainic Acid; Magnesium; Magnetic Resonance Imaging; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2007 |
Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice | 2007 |
Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Anti-Dyskinesia Agents; Botulinum Toxins; Cell Count; Disease Models, Animal; Drug Interactions; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Neuropeptide Y; Reelin Protein; Synaptosomal-Associated Protein 25 | 2008 |
Mitochondrial DNA damage and impaired base excision repair during epileptogenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitum; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Deoxyglucose; Deoxyguanosine; Disease Models, Animal; DNA Glycosylases; DNA Repair; DNA, Mitochondrial; Epilepsy, Temporal Lobe; Fumarate Hydratase; Gene Expression Regulation; Hydrogen Peroxide; Kainic Acid; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Transporter 2; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Hippocampus; Kainic Acid; Male; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Granule cell dispersion develops without neurogenesis and does not fully depend on astroglial cell generation in a mouse model of temporal lobe epilepsy.
Topics: Age Factors; Analysis of Variance; Animals; Astrocytes; Bromodeoxyuridine; Cell Count; Cell Death; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Epilepsy, Temporal Lobe; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphopyruvate Hydratase; Radiation; Statistics, Nonparametric; Time Factors | 2008 |
Differential vulnerability of central neurons of the rat to quinolinic acid.
Topics: Animals; Brain; Corpus Striatum; Diencephalon; Epilepsy, Temporal Lobe; Hippocampus; Huntington Disease; Ibotenic Acid; Kainic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Telencephalon | 1983 |
Excitotoxic models for neurodegenerative disorders.
Topics: Amino Acids; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Hippocampus; Humans; Ibotenic Acid; Kainic Acid; Models, Neurological; Nervous System Diseases; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats | 1984 |
Usefulness of parenteral kainic acid as a model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Brain Damage, Chronic; Disease Models, Animal; Epilepsy, Temporal Lobe; Glucose; Hippocampus; Kainic Acid; Pyrrolidines; Rats; Syndrome | 1984 |
[Astrocyte activation with kainic acid in epileptogenic and non-epileptogenic brain structures and retina of the rat. Histochemical study].
Topics: Animals; Astrocytes; Epilepsy, Temporal Lobe; Hippocampus; Histocytochemistry; Kainic Acid; Oxidoreductases; Pyrrolidines; Rats; Rats, Inbred Strains; Retina; Telencephalon | 1981 |
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Death; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Kainic Acid; Lithium; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1995 |
Simultaneous expression of long-term depression of NMDA and long-term potentiation of AMPA receptor-mediated synaptic responses in the CA1 area of the kainic acid-lesioned hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Long-Term Potentiation; Male; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1995 |
Differential impairments of spatial memory and social behavior in two models of limbic epilepsy.
Topics: Animals; Behavior, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Kindling, Neurologic; Memory; Rats; Social Behavior; Spatial Behavior | 1995 |
Plasticity of AMPA and NMDA receptor-mediated epileptiform activity in a chronic model of temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetany | 1995 |
Delayed cell death in the contralateral hippocampus following kainate injection into the CA3 subfield.
Topics: Animals; Calbindin 2; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Pyramidal Cells; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Silver Staining; Time Factors | 1995 |
Temporal lobe epilepsy caused by domoic acid intoxication: evidence for glutamate receptor-mediated excitotoxicity in humans.
Topics: Aged; Aged, 80 and over; Animals; Bivalvia; Brain; Electroencephalography; Epilepsy, Temporal Lobe; Food Contamination; Humans; Kainic Acid; Male; Marine Toxins; Neurotoxins; Shellfish; Tomography, X-Ray Computed | 1995 |
Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells.
Topics: Animals; Astrocytes; Cell Division; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Nerve Tissue Proteins; Neuroglia; Neurons; Oligodendroglia; Rats; Rats, Wistar; Seizures | 1994 |
Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus.
Topics: Amygdala; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Microtubule-Associated Proteins; Rats; Rats, Wistar; RNA, Messenger; Tubulin | 1994 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; Dominance, Cerebral; Dose-Response Relationship, Drug; Drug Combinations; Epilepsy, Temporal Lobe; Ether; Hippocampus; Injections; Injections, Intraperitoneal; Kainic Acid; Magnesium Sulfate; Male; Necrosis; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Neurons; Pentobarbital; Pyramidal Cells; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Seizures | 1993 |
Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.
Topics: 3T3 Cells; Animals; Base Sequence; Epilepsy, Temporal Lobe; Genetic Vectors; Hippocampus; Kainic Acid; Mice; Molecular Sequence Data; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Simplexvirus; Synapses; Transfection; Vero Cells | 1993 |
Hippocampal quinolinic acid concentrations in epileptogenesis in rats.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Quinolinic Acids; Rats; Rats, Wistar; Time Factors | 1995 |
Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining.
Topics: Adult; Aged; Analysis of Variance; Animals; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Functional Laterality; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Male; Middle Aged; Nerve Fibers; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sclerosis; Staining and Labeling; Synapses | 1996 |
Postictal alteration of sodium content and apparent diffusion coefficient in epileptic rat brain induced by kainic acid.
Topics: Amygdala; Animals; Brain; Brain Chemistry; Disease Models, Animal; Epilepsy, Temporal Lobe; Extracellular Space; Hippocampus; Humans; Intracellular Fluid; Kainic Acid; Magnetic Resonance Imaging; Olfactory Pathways; Putamen; Rats; Rats, Sprague-Dawley; Sodium; Sodium Isotopes | 1996 |
Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain.
Topics: Animals; Brain Chemistry; Calpain; Disease Models, Animal; Enzyme Activation; Epilepsy, Temporal Lobe; Humans; Immunohistochemistry; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Spectrin | 1996 |
Redox sites of NMDA receptors can modulate epileptiform activity in hippocampal slices from kainic acid-treated rats.
Topics: Animals; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Membrane Potentials; Oxidation-Reduction; Phosphines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy.
Topics: Animals; Cell Cycle Proteins; Cell Nucleus; Dual Specificity Phosphatase 1; Epilepsy, Temporal Lobe; Gene Expression Regulation; Immediate-Early Proteins; Kainic Acid; Limbic System; Male; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neurons; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Signal Transduction | 1996 |
Systemic administration of kainate induces marked increases of endogenous kynurenate in various brain regions and plasma of rats.
Topics: Animals; Brain; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Kynurenic Acid; Organ Specificity; Rats; Rats, Wistar | 1996 |
Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats.
Topics: Age Factors; Animals; Cell Count; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Kainic Acid; Male; Nerve Regeneration; Neurofibrils; Rats; Rats, Sprague-Dawley | 1996 |
Enhanced NMDAR-dependent epileptiform activity is controlled by oxidizing agents in a chronic model of temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dithionitrobenzoic Acid; Electric Stimulation; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Male; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuropeptides; Protons; Rats; Rats, Sprague-Dawley; Seizures; Temporal Lobe | 1997 |
Metabolic and pathological effects of temporal lobe epilepsy in rat brain detected by proton spectroscopy and imaging.
Topics: Animals; Aspartic Acid; Behavior, Animal; Choline; Creatine; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Temporal Lobe; Time Factors | 1997 |
Prevention of kainic acid-induced limbic seizures and Fos expression by the GABA-A receptor agonist muscimol.
Topics: Animals; Behavior, Animal; Brain Chemistry; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA Agonists; GABA-A Receptor Agonists; Immunohistochemistry; Kainic Acid; Limbic System; Male; Muscimol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1997 |
Enhanced population responses in the basolateral amygdala of kainate-treated, epileptic rats in vitro.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; In Vitro Techniques; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 1997 |
A novel seizure-induced synaptotagmin gene identified by differential display.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; Calcium-Binding Proteins; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Parietal Lobe; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sequence Homology, Amino Acid; Skates, Fish; Synaptotagmins; Transcription, Genetic | 1997 |
Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70.
Topics: Adult; Animals; Epilepsy, Temporal Lobe; Hippocampus; HSP70 Heat-Shock Proteins; Humans; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Motor Activity; Rats; Rats, Wistar; Seizures; Stereotyped Behavior | 1997 |
Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization.
Topics: Animals; Axons; Brain Mapping; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Kainic Acid; Male; Nerve Degeneration; Nerve Net; Nerve Regeneration; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
GABA(A) receptor subunits in the rat hippocampus II: altered distribution in kainic acid-induced temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Humans; Immunohistochemistry; Interneurons; Kainic Acid; Macromolecular Substances; Male; Nerve Degeneration; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Time Factors | 1997 |
Systemic administration of kainic acid induces selective time dependent decrease in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in adult rat hippocampal formation.
Topics: Animals; Autoradiography; Binding Sites; Cell Survival; Dentate Gyrus; Down-Regulation; Epilepsy, Temporal Lobe; Hippocampus; Humans; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Iodine Radioisotopes; Kainic Acid; Male; Nerve Degeneration; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, IGF Type 2; Receptor, Insulin; Time Factors | 1997 |
The relationship between seizures and damage in the maturing brain.
Topics: Age Factors; Amygdala; Animals; Brain; Brain Damage, Chronic; Brain Mapping; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Kindling, Neurologic; Neurons; Rats; Seizures; Status Epilepticus | 1996 |
Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Enzyme Inhibitors; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kainic Acid; Male; Phenytoin; Rats; Rats, Wistar; Vigabatrin | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Kainic Acid; Male; Motor Activity; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Values | 1998 |
Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Behavior, Animal; Binding, Competitive; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glutamic Acid; In Situ Hybridization; Iodine Radioisotopes; Kainic Acid; Kinetics; Male; Mossy Fibers, Hippocampal; Peptide Fragments; Peptide YY; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; RNA, Messenger; Up-Regulation | 1998 |
Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Epilepsy, Temporal Lobe; Female; Injections, Intraperitoneal; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Time Factors | 1998 |
Deficient sensorimotor gating following seizures in amygdala-kindled rats.
Topics: Acoustic Stimulation; Amygdala; Analysis of Variance; Animals; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Inhibition, Psychological; Kainic Acid; Kindling, Neurologic; Pentylenetetrazole; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia; Seizures | 1998 |
[The effect of hippocampal dentate granule cell lesions upon the limbic seizure model of rats].
Topics: Amygdala; Animals; Colchicine; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Microinjections; Rats; Rats, Wistar; Seizures | 1998 |
Voltage-dependent Ca2+ currents in epilepsy.
Topics: Adult; Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Membrane Potentials; Middle Aged; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides; Rats; Rats, Sprague-Dawley; Reference Values | 1998 |
Hippocampal damage after injection of kainic acid into the rat entorhinal cortex.
Topics: Animals; Convulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microinjections; NADPH Dehydrogenase; Rats; Rats, Wistar; Somatostatin | 1998 |
Hippocampal and entorhinal cortex high-frequency oscillations (100--500 Hz) in human epileptic brain and in kainic acid--treated rats with chronic seizures.
Topics: Action Potentials; Animals; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Electrophysiology; Entorhinal Cortex; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Interneurons; Kainic Acid; Kindling, Neurologic; Male; Microelectrodes; Rats; Rats, Sprague-Dawley; Seizures | 1999 |
In vivo intracellular analysis of granule cell axon reorganization in epileptic rats.
Topics: Action Potentials; Animals; Axons; Cell Count; Cell Size; Dendrites; Dentate Gyrus; Epilepsy, Temporal Lobe; Intracellular Fluid; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley | 1999 |
Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cell Adhesion Molecules, Neuronal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Energy Metabolism; Epilepsy, Temporal Lobe; Fetal Proteins; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glucose; Hippocampus; Hypertrophy; Injections; Kainic Acid; Male; Mice; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neurons; Protein Isoforms; Sclerosis; Seizures; Silver Staining; Synapses | 1999 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; Kainic Acid; Male; Mossy Fibers, Hippocampal; N-Methylaspartate; Organ Culture Techniques; Parasympathomimetics; Patch-Clamp Techniques; Perforant Pathway; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Staining and Labeling; Status Epilepticus; Synapses | 1999 |
Spontaneous motor seizures of rats with kainate-induced epilepsy: effect of time of day and activity state.
Topics: Animals; Behavior, Animal; Darkness; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Light; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Videotape Recording | 1999 |
Long-term increase of Sp-1 transcription factors in the hippocampus after kainic acid treatment.
Topics: Animals; Antibodies; Brain Chemistry; Disease Models, Animal; DNA Primers; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Protein Binding; Rats; Rats, Inbred F344; Sp1 Transcription Factor | 1999 |
Regulation of calcium channel alpha(1A) subunit splice variant mRNAs in kainate-induced temporal lobe epilepsy.
Topics: Alternative Splicing; Animals; Brain; Calcium Channels; Calcium Channels, N-Type; Cerebellum; Disease Models, Animal; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Neocortex; Nerve Tissue Proteins; Protein Isoforms; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 1999 |
Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy.
Topics: Animals; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Nerve Endings; Neural Inhibition; Pilocarpine; Pyramidal Cells; Rats; Receptors, GABA-A; Reference Values; Synapses; Synaptic Vesicles | 1999 |
Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection.
Topics: Animals; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Functional Laterality; Hippocampus; Humans; Kainic Acid; Limbic System; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Telemetry | 1999 |
Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats.
Topics: Animals; Axonal Transport; Axons; Biomarkers; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Glutamate Decarboxylase; Interneurons; Kainic Acid; Male; Nerve Net; Neurons; Rats; Rats, Sprague-Dawley; Somatostatin; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1999 |
A global hypoxia preconditioning model: neuroprotection against seizure-induced specific gravity changes (edema) and brain damage in rats.
Topics: Animals; Brain Edema; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hypoxia, Brain; Ischemic Preconditioning; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Wistar; Specific Gravity | 1999 |
Mapping of the progressive metabolic changes occurring during the development of hippocampal sclerosis in a model of mesial temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Brain Mapping; Carbon Radioisotopes; Deoxyglucose; Disease Models, Animal; Energy Metabolism; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Kainic Acid; Male; Mice; Microinjections; Nerve Degeneration; Sclerosis | 2000 |
Differential expression of S100beta and glial fibrillary acidic protein in the hippocampus after kainic acid-induced lesions and mossy fiber sprouting in adult rat.
Topics: Age Factors; Animals; Blotting, Northern; Calcium-Binding Proteins; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; RNA, Messenger; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2000 |
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Topics: Afferent Pathways; Animals; Brain Chemistry; Cell Survival; Denervation; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Fornix, Brain; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mossy Fibers, Hippocampal; Nerve Degeneration; Perforant Pathway; Rats; Status Epilepticus; Synapses | 1999 |
Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients.
Topics: Adult; Animals; Antibodies; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Up-Regulation | 2000 |
Reduction of A1 adenosine receptors in rat hippocampus after kainic acid-induced limbic seizures.
Topics: Adenosine; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Somatosensory Cortex | 2000 |
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Apyrase; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Subcellular Fractions; Synaptosomes | 2000 |
Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin.
Topics: Animals; Calbindin 2; Calbindins; Calcium-Binding Proteins; Carrier Proteins; Cell Survival; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; GABA Plasma Membrane Transport Proteins; Gene Expression Regulation; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuropeptide Y; Organic Anion Transporters; Parvalbumins; Receptors, GABA-A; S100 Calcium Binding Protein G; Seizures; Somatostatin | 2000 |
Brain distribution and efficacy of carbamazepine in kainic acid induced seizure in rats.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Kainic Acid; Rats; Seizures; Time Factors | 2000 |
Magnetic resonance imaging follow-up of progressive hippocampal changes in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Brain Diseases; Disease Models, Animal; Epilepsy, Temporal Lobe; Follow-Up Studies; Functional Laterality; Gadolinium; Hippocampus; Image Enhancement; Kainic Acid; Magnetic Resonance Imaging; Mice; Microinjections; Nerve Degeneration; Sclerosis; Seizures; Status Epilepticus | 2000 |
Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats.
Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; In Vitro Techniques; Kainic Acid; Lysine; Male; Membrane Potentials; Microscopy, Electron; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Synapses | 2000 |
Early loss of interneurons and delayed subunit-specific changes in GABA(A)-receptor expression in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Calbindin 1; Calbindin 2; Calbindins; Carrier Proteins; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Functional Laterality; GABA Plasma Membrane Transport Proteins; Immunohistochemistry; Interneurons; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Organic Anion Transporters; Parvalbumins; Receptors, GABA-A; S100 Calcium Binding Protein G; Time Factors | 2000 |
Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Lipid Peroxidation; Oxidative Stress; Pilocarpine; Rats; Rats, Wistar; Reactive Oxygen Species; Status Epilepticus; Thiobarbituric Acid Reactive Substances | 2000 |
Characterization of benzodiazepine receptor binding in immature rat brain after kainic acid administration.
Topics: Age Factors; Animals; Autoradiography; Brain; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal Lobe; Flunitrazepam; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, GABA-A; Status Epilepticus; Tritium | 2000 |
Glutamate receptor activation in the kindled dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Entorhinal Cortex; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Kainic Acid; Kindling, Neurologic; Neural Pathways; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Chromogranins in temporal lobe epilepsy.
Topics: Animals; Biomarkers; Chromogranins; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Mossy Fibers, Hippocampal; Neuropeptides; Rats; Secretogranin II | 2000 |
Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry.
Topics: Animals; Dendrites; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microscopy, Electron; Mossy Fibers, Hippocampal; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2000 |
Effect of theophylline and trimethobenzamide when given during kainate-induced status epilepticus: an improved histopathologic rat model of human hippocampal sclerosis.
Topics: Animals; Benzamides; Brain Diseases; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Hypertension; Kainic Acid; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Sclerosis; Status Epilepticus; Theophylline | 2000 |
Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Cell Count; Cell Size; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Glutamate Decarboxylase; Graft Survival; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Interneurons; Isoenzymes; Kainic Acid; Male; Rats; Rats, Inbred F344 | 2000 |
Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.
Topics: Action Potentials; Animals; Calbindins; Dendrites; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; In Vitro Techniques; Interneurons; Isoenzymes; Kainic Acid; Muscarinic Agonists; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Rats; RNA, Messenger; S100 Calcium Binding Protein G; Somatostatin | 2001 |
Short- and long-term changes in CA1 network excitability after kainate treatment in rats.
Topics: Animals; Axons; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Time | 2001 |
Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration.
Topics: Animals; Biomarkers; Citrulline; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hydrolases; Imines; Kainic Acid; Microtubule-Associated Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Rats; Rats, Wistar; Telencephalon | 2001 |
Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities.
Topics: Animals; Cytoskeleton; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; SAP90-PSD95 Associated Proteins; Seizures; Subcellular Fractions; Synaptic Membranes; Tyrosine | 2001 |
Excitatory synaptic input to granule cells increases with time after kainate treatment.
Topics: Action Potentials; Animals; Bicuculline; Coloring Agents; Convulsants; Cytoplasmic Granules; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Photic Stimulation; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2001 |
Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy.
Topics: Animals; Dendrites; Dentate Gyrus; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Microfilament Proteins; Nerve Fibers; Neurons; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 2001 |
Changes in neuronal excitability and synaptic function in a chronic model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Chronic Disease; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Long-Term Potentiation; Potassium Channel Blockers; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetraethylammonium | 2001 |
Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis.
Topics: Animals; Bicuculline; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; GABA Antagonists; Kainic Acid; Male; Membrane Potentials; Mossy Fibers, Hippocampal; Nerve Degeneration; Neural Inhibition; Neuronal Plasticity; Neurons; Perforant Pathway; Rats; Rats, Long-Evans; Synaptic Transmission | 2001 |
Kainate-induced epilepsy alters protein expression of AMPA receptor subunits GluR1, GluR2 and AMPA receptor binding protein in the rat hippocampus.
Topics: Animals; Carrier Proteins; Cell Survival; Dentate Gyrus; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; Receptors, AMPA | 2001 |
Ibotenate injections into the pre- and parasubiculum provide partial protection against kainate-induced epileptic damage in layer III of rat entorhinal cortex.
Topics: Animals; Convulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Ibotenic Acid; Kainic Acid; Male; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2001 |
Calcium/calmodulin kinase II activity of hippocampus in kainate-induced epilepsy.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Long-Term Potentiation; Male; Rats; Rats, Wistar | 2001 |
c-JUN expression and apoptotic cell death in kainate-induced temporal lobe epilepsy.
Topics: Animals; Apoptosis; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar | 2001 |
Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy.
Topics: Aging; Animals; Biomarkers; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Count; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Graft Survival; Hippocampus; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Pyramidal Cells; Rats; Rats, Inbred F344 | 2001 |
Effect of oxcarbazepine on kainic acid-induced seizure.
Topics: Animals; Anticonvulsants; Carbamazepine; Electrodes, Implanted; Electroencephalography; Electrophysiology; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Male; Oxcarbazepine; Rats; Rats, Wistar; Seizures | 2001 |
Increased afterdischarge threshold during kindling in epileptic rats.
Topics: Animals; Electric Stimulation; Electric Stimulation Therapy; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Membrane Potentials; Neurons; Neurotoxins; Perforant Pathway; Rats; Rats, Sprague-Dawley; Reaction Time; Synaptic Transmission; Up-Regulation | 2002 |
Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.
Topics: Animals; Cell Count; Cell Size; Cell Survival; Cytoskeletal Proteins; Dentate Gyrus; Dystrophin; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Genotype; Hypertrophy; Immunohistochemistry; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Nerve Degeneration; Neurons; RNA, Messenger; Up-Regulation; Utrophin | 2002 |
Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Mice; Sclerosis; Status Epilepticus | 2002 |
Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes of the rat hippocampus following kainic acid-induced seizure.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Blotting, Western; Carrier Proteins; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Male; Neurons; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley | 2002 |
Sex differences in models of temporal lobe epilepsy: role of testosterone.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Hypothalamo-Hypophyseal System; Kainic Acid; Male; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Sex Characteristics; Testosterone | 2002 |
Temporal lobe epilepsy of the rat: differential expression of mRNAs of chromogranin B, secretogranin II, synaptin/synaptophysin and p65 in subfield of the hippocampus.
Topics: Animals; Calcium-Binding Proteins; Chromogranin B; Chromogranins; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Membrane Glycoproteins; Membrane Proteins; Nerve Tissue Proteins; Pentylenetetrazole; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synaptophysin; Synaptotagmin I; Synaptotagmins | 1992 |
Synaptic reorganizations in epileptic human and rat kainate hippocampus may contribute to feedback and feedforward excitation.
Topics: Animals; Diffuse Cerebral Sclerosis of Schilder; Epilepsy, Temporal Lobe; Feedback; Female; Hippocampus; Humans; Kainic Acid; Male; Microscopy, Electron; Middle Aged; Nerve Fibers; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 1992 |
Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats.
Topics: Action Potentials; Afferent Pathways; Animals; Axons; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Synapses | 1992 |
Local circuit synaptic interactions between CA1 pyramidal cells and interneurons in the kainate-lesioned hyperexcitable hippocampus.
Topics: Animals; Cell Communication; Epilepsy, Temporal Lobe; Interneurons; Kainic Acid; Male; Pyramidal Cells; Rats; Synaptic Transmission | 1991 |
Long-term increase of glutamate decarboxylase mRNA in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Survival; Epilepsy, Temporal Lobe; Glutamate Decarboxylase; Hippocampus; Kainic Acid; Male; Neurons; Osmolar Concentration; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin; Time Factors | 1990 |
Altered distribution of excitatory amino acid receptors in temporal lobe epilepsy.
Topics: Adult; Aged; Autoradiography; Brain Mapping; Brain Neoplasms; Child, Preschool; Epilepsy, Temporal Lobe; Female; Hamartoma; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; Neuroblastoma; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Combined kainate and ischemia produces 'mesial temporal sclerosis'.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Inbred Strains; Sclerosis; Temporal Lobe | 1990 |
Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat.
Topics: Animals; Epilepsy, Temporal Lobe; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neuropeptide Y; Nucleic Acid Hybridization; Pentylenetetrazole; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Epileptic phenomena produced by kainic acid in laboratory rats during ontogenesis.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred Strains | 1988 |
Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Kainic Acid; Male; Neural Inhibition; Rats; Rats, Inbred Strains; Synaptic Transmission | 1986 |
Ictal and enduring interictal disturbances in emotional behaviour in an animal model of temporal lobe epilepsy.
Topics: Animals; Cats; Defense Mechanisms; Electroencephalography; Emotions; Epilepsies, Partial; Epilepsy, Temporal Lobe; Irritable Mood; Kainic Acid; Recurrence | 1987 |
Brain damage caused by seizure activity.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Limbic System; Rats; Seizures | 1987 |
Pro-convulsant actions of theophylline and caffeine in the hippocampus: implications for the management of temporal lobe epilepsy.
Topics: Animals; Caffeine; Convulsants; Drug Interactions; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline | 1987 |
Long term sequelae of parenteral administration of kainic acid.
Topics: Amygdala; Animals; Brain; Cerebral Cortex; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Limbic System; Neuroglia; Rats; Sclerosis; Seizures; Thalamic Nuclei; Time Factors | 1986 |
Electrophysiology of epileptic tissue: what pathologies are epileptogenic?
Topics: Action Potentials; Animals; Cerebral Cortex; Epilepsy; Epilepsy, Temporal Lobe; Gliosis; Guinea Pigs; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Neural Inhibition | 1986 |