kainic acid has been researched along with Astrocytosis in 99 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.04) | 18.7374 |
| 1990's | 19 (19.19) | 18.2507 |
| 2000's | 43 (43.43) | 29.6817 |
| 2010's | 28 (28.28) | 24.3611 |
| 2020's | 5 (5.05) | 2.80 |
| Authors | Studies |
|---|---|
| Bolton, EC; Christian-Hinman, CA; Chung, HJ; Kim, EC; Rhodes, JS; Tang, AY; Zhang, J | 1 |
| Boitet, M; Eun, H; Grailhe, R; Kim, J; Lee, T | 1 |
| Anagnostou, I; Morales, T | 1 |
| Morales, T; Reyes-Mendoza, J | 2 |
| Baluchnejadmojarad, T; Barati, H; Goudarzi, M; Jamali-Raeufy, N; Roghani, M | 1 |
| Alvarez de la Rosa, D; Armas-Capote, N; Giraldez, T; Hernández, G; Maglio, LE; Martin-Batista, E | 1 |
| Chi, Y; Guan, J; Guo, Y; Li, X; Lu, Z; Rao, J; Wu, B; Xiao, K; Xu, Q; Xu, Y; Xue, S | 1 |
| Dingledine, R; Du, Y; Jiang, J; Kinjo, ER; Nguyen, HP; Yu, Y | 1 |
| Bosco, DB; Feng, L; Liu, Y; Murugan, M; Peng, J; Richardson, JR; Shen, Y; Ta, LE; Wang, HL; Worrell, GA; Wu, LJ | 1 |
| Li, F; Liu, L | 1 |
| Takahashi, DK; Thomson, KE; Vargas, JR; Wilcox, KS | 1 |
| Bauer, CS; Dolphin, AC; Jefferys, JG; Jiruska, P; Nieto-Rostro, M; Sandhu, G | 1 |
| Choi, DJ; Choi, I; Jeong, HK; Ji, KM; Joe, EH; Jou, I; Min, KJ | 1 |
| Bialecki, RA; Kirkley, KA; Liang, LP; Miller, JA; Padmanabhan, R; Patel, M; Raol, YH; Tjalkens, RB | 1 |
| Abad, S; Auladell, C; Camarasa, J; Camins, A; Escubedo, E; Junyent, F; Pallàs, M; Pubill, D | 1 |
| Han, H; Jang, T; Jeong, JW; Kang, JS; Kim, IH; Lee, GW; Lee, JK | 1 |
| Depaulis, A; Laharie, AM; Nitta, N; Nozaki, K; Shima, A; Suzuki, F | 1 |
| Aguilar-Calvo, P; Carulla, P; del Río, JA; Espinosa, JC; Ferrer, I; Gavín, R; Legname, G; Llorens, F; Matamoros-Angles, A; Torres, JM | 1 |
| Berretta, N; Cecconi, F; Cervelli, M; Cervetto, C; D'Amelio, M; Marcoli, M; Mariottini, P; Maura, G; Mercuri, N; Passalacqua, M; Ragazzoni, M; Venturini, A; Vergani, L; Voci, A | 1 |
| Agostinho, AS; Burtscher, J; Fogli, B; Hausott, B; Klimaschewski, L; Marvaldi, L; Schwarzer, C; Thongrong, S; Zangrandi, L | 1 |
| Aronica, E; de Vries, HE; Dijkhuizen, RM; Gorter, JA; Kooij, G; Otte, WM; van Vliet, EA; Wadman, WJ | 1 |
| Bennett, IV; Nebeker, LD; Newell, TG; Thomson, KE; Tian, BB; Umpierre, AD; White, HS; White, JA; Wilcox, KS | 1 |
| Hall, DG; Jordan, WH; Reams, RY; Sharma, AK; Snyder, PW | 1 |
| Gao, S; Ho, G; Kng, YL; Kumar, S; Loh, MY; Min, XS; Zhuo, L | 1 |
| Han, PL; Jin, Y; Kim, SW; Lee, JK; Lim, CM; Park, JY; Seo, JS; Yoon, SH | 1 |
| Chung, HY; Handa, S; Ishigami, A; Kim, K; Kim, MS; Kim, SJ; Lee, J; Maruyama, N; Park, HR; Son, TG | 1 |
| Abdipranoto-Cowley, A; Croucher, D; Daniel, J; Galbraith, S; Henshall, S; Mervin, K; Park, JS; Vissel, B | 1 |
| Foote, LT; Kazl, C; Kim, MJ; Koh, S | 1 |
| Luna-Medina, R; Martinez, A; Morales-Garcia, JA; Perez-Castillo, A; Santos, A | 1 |
| Jaako, K; Zharkovsky, A; Zharkovsky, T | 1 |
| Boison, D; Lan, JQ; Li, T | 1 |
| Miltiadous, P; Stamatakis, A; Stylianopoulou, F | 1 |
| Aguado, F; Auladell, C; Camins, A; De Lemos, L; Junyent, F; Paco, S; Pallàs, M; Romero, R; Utrera, J | 1 |
| Agrawal, L; Chekmasova, A; Louboutin, JP; Marusich, E; Strayer, DS | 1 |
| Chintala, SK; Ganesh, BS | 1 |
| Banares, S; Hakem, R; Head, BP; Hu, Y; Huang, X; Krajewska, M; Krajewski, S; Kress, C; Kyoda, T; Leyva, R; Reed, JC; Rong, J; Salmena, L; Sze, CH; Whalen, MJ; Yang, J; You, Z | 1 |
| Boison, D; Lan, JQ; Li, T; Lytle, N; Sandau, US | 1 |
| Aras, R; Barron, AM; Pike, CJ | 1 |
| Raymick, J; Sarkar, S; Schmued, L | 1 |
| Denslow, N; Glushakova, OY; Hayes, RL; Jeromin, A; Johnson, D; Martinez, J; Mondello, S; Streeter, J | 1 |
| Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T | 1 |
| Doncarlos, LL; García-Ovejero, D; García-Segura, LM; Veiga, S | 1 |
| Ahn, JG; Cho, J; Cho, SS; Kim, HS; Kim, SS; Lee, SH; Seo, JH; Song, DK; Yim, SV | 1 |
| Ananth, C; Gopalakrishnakone, P; Kaur, C | 1 |
| Aliprandi, M; Colella, D; De Simoni, MG; Moshé, SL; Perego, C; Ravizza, T; Richichi, C; Rizzi, M; Velískŏvá, J; Vezzani, A | 1 |
| Auyeung, WW; Lee, J; Mattson, MP | 1 |
| Pérez-Clausell, J; Riba-Bosch, A | 1 |
| Anderson, PN; Bethea, JR; Burgaya, F; del Río, JA; Fontana, X; Hunt, D; Mingorance, A; Schwab, ME; Solé, M; Soriano, E; Tang, BL; Teng, FY; Ureña, JM | 1 |
| Cho, J; Cho, SS; Jeon, GS; Kim, DW; Kim, SD; Lim, SY; Park, SW; Seo, JH | 1 |
| Adem, A; Chen, Z; Duan, RS; Mix, E; Nennesmo, I; Quezada, HC; Winblad, B; Zhu, J | 1 |
| Azcoitia, I; Garcia-Segura, LM; Veiga, S | 1 |
| Boison, D; Crestani, F; Fedele, DE; Gabernet, L; Gouder, N; Güttinger, M; Rülicke, T; Scheurer, L | 1 |
| De Simoni, MG; Moshé, SL; Perego, C; Ravizza, T; Richichi, C; Rizzi, M; Velísková, J; Vezzani, A | 1 |
| Joseph, SA; Lynd-Balta, E; Rappold, PM | 1 |
| Allen, A; Daschner, J; Joseph, SA; Lynd-Balta, E; O'Banion, MK; Padowski, J; Rappold, PM | 1 |
| Chen, Z; Duan, RS; Mix, E; Quezada, HC; Winblad, B; Zhang, XM; Zhu, J | 1 |
| Ho, G; Zhang, C; Zhuo, L | 1 |
| Sanagi, T; Yabe, T; Yamada, H | 1 |
| Ercan, F; Erkanli, G; Onat, F; Salik, E; San, T; Sirvanci, S; Yananli, HR | 1 |
| Kaur, G; Sharma, S | 1 |
| Akahoshi, N; Himi, T; Ishii, I; Ishizaki, Y; Murashima, YL | 1 |
| Einula, C; Gröhn, OH; Immonen, RJ; Kharatishvili, I; Pitkänen, A; Sierra, A | 1 |
| Ben-Ari, Y; Faissner, A; Jorquera, I; Niquet, J; Represa, A | 1 |
| Bennett, SA; Roberts, DC; Staines, WA; Stevenson, B | 1 |
| Hong, JS; McMillian, MK; Pennypacker, KR; Thai, L | 1 |
| Joggerst, B; Otten, U; Plüss, K; Strauss, S; Volk, B | 1 |
| Bovolenta, P; Fernaud-Espinosa, I; Nieto-Sampedro, M | 1 |
| Bing, G; Chen, J; Hong, JS; McMillian, MK; Pennypacker, KR; Pérez-Otano, I | 1 |
| Araujo, M; Wandosell, F | 1 |
| Abraham, CR; Mallory, M; Masliah, E; Mucke, L; Rockenstein, EM; Sheldon, E; Veinberg, I; Westland, CE | 1 |
| Achaval, M; Gottardo, S; Lenz, G; Manozzo, L; Rodnight, R; Salbego, C | 1 |
| Jabs, R; Paterson, IA; Walz, W | 1 |
| Graham, DI; MacGregor, DG; Stone, TW | 1 |
| Bausch, SB; Catterall, WA; Franck, JE; Lin, RC; Noebels, JL; Westenbroek, RE | 1 |
| Bennett, SA; Chen, J; Pappas, BA; Roberts, DC; Tenniswood, M | 1 |
| Walz, W; Wuttke, WA | 1 |
| Anadón, R; Carpintero, P; Gómez-Márquez, J | 1 |
| Alhonen, L; Jänne, J; Kaasinen, K; Koistinaho, J | 1 |
| Ding, M; Haglid, KG; Hamberger, A | 1 |
| Balázs, R; Cotman, CW; Ivins, KJ; Kesslak, JP; Satou, T; Ulas, J | 1 |
| Halliwell, B; Hu, CY; Lu, XR; Ong, WY | 1 |
| Fujikawa, DG; Itabashi, HH; Shinmei, SS; Wu, A | 1 |
| Carrasco, J; Hidalgo, J; Molinero, A; Penkowa, M | 1 |
| Corti, C; Ferraguti, F; Mion, S; Valerio, E; Xuereb, J | 1 |
| Abrahám, H; Czéh, G; Lázár, G; Losonczy, A | 1 |
| Che, Y; Han, PL; Lee, JK; Piao, CS | 1 |
| Che, Y; Han, PL; Lee, JK; Yu, YM | 1 |
| Chabot, JG; Mennicken, F; Quirion, R | 1 |
| Bogdanovic, N; Chen, Z; Ljunggren, HG; Nennesmo, I; Winblad, B; Zhu, J | 1 |
| Lu, W; Rogove, AD; Tsirka, SE | 1 |
| Jones, MZ; Lovell, KL; Moore, KE; Wuerthele, SM | 1 |
| Matsuda, Y; Miyamoto, S; Nakagawa, H; Sano, S; Shiraki, H | 1 |
| Anderson, EJ; Kimelberg, HK; McFarland, D | 1 |
| Morshead, CM; van der Kooy, D | 1 |
| Altar, CA; Baudry, M | 1 |
| Nitecka, L; Tremblay, E | 1 |
| Franck, JE; Schwartzkroin, PA | 1 |
| Hanretta, AT; Lombardini, JB | 1 |
99 other study(ies) available for kainic acid and Astrocytosis
| Article | Year |
|---|---|
Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of K
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Epileptic Syndromes; Female; Gliosis; Hippocampus; Kainic Acid; KCNQ2 Potassium Channel; Male; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Pyramidal Cells | 2021 |
Non-invasive In Vivo Brain Astrogenesis and Astrogliosis Quantification Using a Far-red E2-Crimson Transgenic Reporter Mouse.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Longitudinal Studies; Mice; Mice, Transgenic | 2022 |
Fatherhood diminishes the hippocampal damaging action of excitotoxic lesioning in mice.
Topics: Animals; Female; Gliosis; Hippocampus; Infusions, Intraventricular; Kainic Acid; Male; Mice; Nerve Degeneration; Nesting Behavior; Paternity; Phosphorylation; Prolactin; Proto-Oncogene Proteins c-akt; Receptors, Prolactin; STAT5 Transcription Factor | 2019 |
Prolactin treatment reduces kainic acid-induced gliosis in the hippocampus of ovariectomized female rats.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Excitatory Amino Acid Agonists; Female; Gliosis; Inflammation; Kainic Acid; Neuroprotective Agents; Ovariectomy; Prolactin; Rats; Rats, Wistar | 2020 |
Combination therapy with dipeptidyl peptidase-4 and P2X7 purinoceptor inhibitors gives rise to antiepileptic effects in rats.
Topics: Animals; Anticonvulsants; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; DNA Fragmentation; Drug Therapy, Combination; Electroencephalography; Epilepsy; Gliosis; Hippocampus; Kainic Acid; Linagliptin; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Rosaniline Dyes; Seizures; Treatment Outcome | 2020 |
SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; Cell Survival; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Immediate-Early Proteins; Kainic Acid; Mice; Mice, Transgenic; Microfilament Proteins; Neuroglia; Neurons; Protein Serine-Threonine Kinases; Status Epilepticus | 2021 |
Establishment of a rhesus monkey model of chronic temporal lobe epilepsy using repetitive unilateral intra-amygdala kainic acid injections.
Topics: Amygdala; Animals; Chronic Disease; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Functional Laterality; Gliosis; Infusion Pumps, Implantable; Kainic Acid; Macaca mulatta; Male; Neurosurgical Procedures; Pyramidal Cells; Seizures; Temporal Lobe | 2017 |
Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cytokines; Dinoprostone; Disease Models, Animal; Gliosis; Hippocampus; Indoles; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Receptors, Prostaglandin E, EP2 Subtype; Seizures; Signal Transduction; Status Epilepticus | 2019 |
Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus.
Topics: Animals; Calcium-Binding Proteins; Cell Death; Cell Proliferation; CX3C Chemokine Receptor 1; Disease Models, Animal; Gliosis; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Monocytes; Neurons; Receptor, Macrophage Colony-Stimulating Factor; Receptors, CCR2; Status Epilepticus; Tissue Culture Techniques | 2019 |
Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Female; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Microglia; Neurons; Seizures; Sex Factors | 2019 |
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Neurons; Pilocarpine; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Status Epilepticus | 2013 |
Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; CD11b Antigen; Cell Death; Disease Models, Animal; Epilepsy; Ganglia, Spinal; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Ligation; Male; Microtubule-Associated Proteins; Neuralgia; Neurotoxins; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tetanus Toxin | 2014 |
Astrogliosis is a possible player in preventing delayed neuronal death.
Topics: Animals; Astrocytes; Biomarkers; Brain Injuries; Cell Communication; Cell Death; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Gliosis; Glutamate-Ammonia Ligase; Kainic Acid; Male; N-Methylaspartate; Neurons; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; S100 Calcium Binding Protein beta Subunit | 2014 |
Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice.
Topics: Animals; Brain; Female; Genes, Reporter; Gliosis; Green Fluorescent Proteins; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; NF-kappa B; Pyramidal Cells; Seizures; Signal Transduction | 2014 |
3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility.
Topics: Animals; Astrocytes; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Gliosis; Hallucinogens; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Microglia; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Random Allocation; Seizures | 2014 |
Decursin attenuates kainic acid-induced seizures in mice.
Topics: Animals; Benzopyrans; Butyrates; Cerebral Cortex; Electroencephalography; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fos; Seizures | 2014 |
Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Disease Models, Animal; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Midazolam; Neural Inhibition; Neurons; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2015 |
Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.
Topics: Animals; Biomarkers; Cell Death; Cell Line; Cytokines; Disease Models, Animal; Gene Expression; Genetic Predisposition to Disease; Gliosis; Hippocampus; Inflammation Mediators; Kainic Acid; Mice; Mice, Knockout; PrPC Proteins; Seizures; Transfection | 2015 |
Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse.
Topics: Animals; Aspartic Acid; Astrocytes; Benzodiazepines; Biogenic Polyamines; Calcium; Cerebral Cortex; Enzyme Induction; Genetic Predisposition to Disease; Gliosis; Hippocampus; Kainic Acid; Male; Metallothionein; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Neurotoxins; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Receptors, AMPA; Recombinant Fusion Proteins; Seizures; Synaptosomes; Up-Regulation | 2016 |
Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Topics: Analysis of Variance; Animals; Brain Injuries; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Pentylenetetrazole; Protein Serine-Threonine Kinases; RNA, Messenger; Seizures; Signal Transduction | 2016 |
Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood Vessels; Blood-Brain Barrier; Brain; Disease Models, Animal; Electric Impedance; Excitatory Amino Acid Agonists; Gliosis; Immunosuppressive Agents; Kainic Acid; Lectins; Macrophages; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Sirolimus; Status Epilepticus; Tumor Necrosis Factor-alpha | 2016 |
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures.
Topics: Animals; Astrocytes; Cell Death; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptor, Metabotropic Glutamate 5; Seizures; Status Epilepticus | 2016 |
Post-treatment with prolactin protects hippocampal CA1 neurons of the ovariectomized female rat against kainic acid-induced neurodegeneration.
Topics: Animals; Antigens, Nuclear; Astrocytes; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Female; Gliosis; Kainic Acid; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurogenesis; Neurons; Neuroprotective Agents; Ovariectomy; Prolactin; Random Allocation; Rats; Time Factors | 2016 |
Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid-induced mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Behavior, Animal; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microglia; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Inbred F344; Seizures; Status Epilepticus; Thalamus | 2008 |
Molecular imaging of retinal gliosis in transgenic mice induced by kainic acid neurotoxicity.
Topics: Animals; Brain Diseases; Diagnostic Imaging; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescence; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Mice; Mice, Transgenic; Neurotoxicity Syndromes; Ophthalmoscopes; Optic Nerve; Retinal Diseases | 2009 |
Fluoxetine attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.
Topics: Animals; Astrocytes; Avoidance Learning; Cell Death; Cyclooxygenase 2; Dose-Response Relationship, Drug; Fluoxetine; Gliosis; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Memory; Memory Disorders; Mice; Mice, Inbred BALB C; Microglia; Neurons; Neuroprotective Agents; NF-kappa B; Tumor Necrosis Factor-alpha | 2009 |
Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.
Topics: Aging; Animals; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Cell Line; Cerebellum; Cerebral Cortex; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Oxidative Stress; Rats; Rats, Inbred F344; Seizures; Signal Transduction; Specific Pathogen-Free Organisms | 2009 |
Activin A is essential for neurogenesis following neurodegeneration.
Topics: Activins; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Gliosis; Hippocampus; Inflammation; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurogenesis | 2009 |
Early-life experience alters response of developing brain to seizures.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Brain; Convulsants; Disease Models, Animal; Encephalitis; Environmental Exposure; Epilepsy; Exploratory Behavior; Female; Gliosis; Hippocampus; Kainic Acid; Male; Maternal Deprivation; Microglia; Nerve Degeneration; Physical Stimulation; Rats; Time | 2009 |
Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Astrocytes; Benzamides; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytoprotection; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Time Factors | 2009 |
Effects of repeated citalopram treatment on kainic acid-induced neurogenesis in adult mouse hippocampus.
Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Cell Count; Cell Proliferation; Citalopram; Gliosis; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Neurogenesis; Neurons | 2009 |
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.
Topics: Adenosine Kinase; Animals; Astrocytes; Brain; Cell Death; Chronic Disease; Epilepsy; Gliosis; Kainic Acid; Male; Mice; Mice, Knockout; Mice, Transgenic; Pyramidal Cells; Recurrence; Seizures; Severity of Illness Index; Status Epilepticus; Time Factors; Tissue Distribution; Transgenes; Up-Regulation | 2008 |
Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat.
Topics: Animals; Biomarkers; Cell Death; Cytoprotection; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluoresceins; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; HSP72 Heat-Shock Proteins; Insulin-Like Growth Factor I; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organic Chemicals; Rats; Rats, Wistar; Staining and Labeling; Stress, Physiological | 2010 |
Content and traffic of taurine in hippocampal reactive astrocytes.
Topics: Animals; Astrocytes; Base Sequence; Biological Transport, Active; Carboxy-Lyases; Cells, Cultured; Cytokines; DNA Primers; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Inflammation Mediators; Kainic Acid; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; RNA, Messenger; Taurine | 2011 |
Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage.
Topics: Animals; Blood-Brain Barrier; Brain; Chemokine CCL3; Chemokine CCL5; Female; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Ligands; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, CCR5; Regeneration; RNA Interference; Seizures | 2011 |
Inhibition of reactive gliosis attenuates excitotoxicity-mediated death of retinal ganglion cells.
Topics: 2-Aminoadipic Acid; Animals; Apoptosis; Gliosis; Glycosphingolipids; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Retina; Retinal Ganglion Cells; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2011 |
Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Caspase 8; Cell Death; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Gene Deletion; Gliosis; Inflammation; Kainic Acid; Memory; Mice; Neurons; Neurotoxins; Seizures; Tumor Necrosis Factor-alpha | 2011 |
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis?
Topics: Adenosine; Adenosine Kinase; Amygdala; Animals; Disease Models, Animal; Electroencephalography; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Seizures; Time Factors | 2012 |
Caspase activation contributes to astrogliosis.
Topics: Animals; Apoptosis; Astrocytes; Caspases; Cells, Cultured; Fibroblast Growth Factor 2; Gliosis; Glutamate-Ammonia Ligase; Hippocampus; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley | 2012 |
Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Cerebral Arteries; Disease Models, Animal; Disease Progression; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Laminin; Male; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Time Factors; Up-Regulation | 2012 |
Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Male; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Spectrin; Ubiquitin Thiolesterase; Up-Regulation | 2012 |
N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
Topics: Animals; Arginine; Brain Waves; Dentate Gyrus; Diazepam; Disease Models, Animal; Gliosis; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-fos; Seizures; Status Epilepticus; Synapses; Synaptophysin; Telemetry | 2012 |
Glial expression of estrogen and androgen receptors after rat brain injury.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Disease Models, Animal; Estrogen Receptor alpha; Estrogen Receptor beta; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Lectins; Male; Microglia; Nerve Degeneration; Nerve Regeneration; Neuroglia; Plant Lectins; Rats; Rats, Wistar; Receptors, Androgen; Receptors, Estrogen; Vimentin | 2002 |
Increased expression of phosphatase and tensin homolog in reactive astrogliosis following intracerebroventricular kainic acid injection in mouse hippocampus.
Topics: Animals; Astrocytes; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred ICR; Phosphoric Monoester Hydrolases; PTEN Phosphohydrolase; Time Factors; Tumor Suppressor Proteins | 2002 |
Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Astrocytes; Avian Proteins; Basigin; Blood Proteins; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Kainic Acid; Male; Melatonin; Membrane Glycoproteins; Microglia; Microscopy, Electron; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; RNA, Messenger | 2003 |
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Gliosis; Hippocampus; Inflammation Mediators; Interleukin 1 Receptor Antagonist Protein; Kainic Acid; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Status Epilepticus; Up-Regulation | 2003 |
Interactive effects of excitotoxic injury and dietary restriction on microgliosis and neurogenesis in the hippocampus of adult mice.
Topics: Animals; Bromodeoxyuridine; Cell Division; Down-Regulation; Epilepsy; Food Deprivation; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Nerve Regeneration; Neurons; Neurotoxins; Stem Cells | 2003 |
Response to kainic acid injections: changes in staining for zinc, FOS, cell death and glial response in the rat forebrain.
Topics: Animals; Cell Compartmentation; Cell Death; Cytoplasm; Fluoresceins; Fluorescent Dyes; Gliosis; Glutamic Acid; Kainic Acid; Male; Nerve Degeneration; Neurotoxins; Organic Chemicals; Presynaptic Terminals; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Reaction Time; Seizures; Synaptic Transmission; Synaptic Vesicles; Zinc | 2004 |
Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions.
Topics: Animals; Animals, Newborn; Antibodies; Astrocytes; Brain Injuries; COS Cells; Entorhinal Cortex; Fetus; Gene Expression Regulation, Developmental; Gliosis; GPI-Linked Proteins; Growth Cones; Hippocampus; Kainic Acid; Mice; Myelin Proteins; Nerve Regeneration; Neuronal Plasticity; Nogo Proteins; Nogo Receptor 1; Perforant Pathway; Receptors, Cell Surface; Receptors, Peptide; RNA, Messenger | 2004 |
Glial expression of the 90-kDa heat shock protein (HSP90) and the 94-kDa glucose-regulated protein (GRP94) following an excitotoxic lesion in the mouse hippocampus.
Topics: Animals; Antioxidants; Astrocytes; Biomarkers; Calcium-Binding Proteins; Encephalitis; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Injections, Intraventricular; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Microfilament Proteins; Microglia; Nerve Degeneration; Neuroglia; Neurotoxins; Oxidative Stress; Pyramidal Cells | 2004 |
Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL/6 mice.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Blotting, Western; Brain; Cell Count; Excitatory Amino Acid Agonists; fas Receptor; Flow Cytometry; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Time Factors | 2005 |
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity.
Topics: Animals; Benzodiazepinones; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Isoquinolines; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, GABA; Vimentin | 2005 |
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.
Topics: Adenosine Kinase; Animals; Astrocytes; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Locomotion; Male; Mice; Mice, Transgenic; Neurons; Transgenes; Tubercidin; Up-Regulation | 2005 |
Inflammatory response and glia activation in developing rat hippocampus after status epilepticus.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Western; Cytokines; Disease Models, Animal; Gliosis; Hippocampus; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-6; Kainic Acid; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Status Epilepticus; Tumor Necrosis Factor-alpha | 2005 |
P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain.
Topics: Animals; Astrocytes; Biomarkers; Brain; Calcium-Binding Proteins; Convulsants; Cyclooxygenase 1; Disease Models, Animal; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Male; Membrane Proteins; Microfilament Proteins; Microglia; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2006 |
Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures.
Topics: Animals; Biomarkers; Convulsants; Cyclooxygenase 2; Disease Models, Animal; Encephalitis; Epilepsy; Gliosis; Glutamic Acid; Immunohistochemistry; Kainic Acid; Limbic System; Male; Microglia; Olfactory Pathways; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Up-Regulation | 2006 |
IL-18 deficiency aggravates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice due to an overcompensation by IL-12.
Topics: Adaptation, Physiological; Animals; Astrocytes; Female; Gliosis; Hippocampus; Interferon-gamma; Interleukin-12; Interleukin-18; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Motor Activity; Nerve Degeneration; Recombinant Proteins; Severity of Illness Index | 2007 |
Non-invasive fluorescent imaging of gliosis in transgenic mice for profiling developmental neurotoxicity.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Western; Cerebral Ventricles; Diagnostic Imaging; Excitatory Amino Acid Agonists; Fluorescence; Glial Fibrillary Acidic Protein; Gliosis; Green Fluorescent Proteins; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Mice; Mice, Transgenic; Microscopy, Confocal; Neurotoxicity Syndromes; Neurotoxins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Tyrosine 3-Monooxygenase | 2007 |
Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat.
Topics: Animals; Astrocytes; Calbindins; Cerebellar Diseases; Cerebellum; Eye Proteins; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; In Situ Hybridization, Fluorescence; Kainic Acid; Male; Microglia; Nerve Degeneration; Nerve Growth Factors; Neurotoxins; Plant Lectins; Purkinje Cells; Rats; Rats, Wistar; RNA, Messenger; S100 Calcium Binding Protein G; Serpins; Up-Regulation | 2007 |
Time-dependent changes in distribution of basic fibroblast growth factor immunoreactive cells in hippocampus after kainic acid injection in rat pups.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Count; Cell Death; Disease Progression; Down-Regulation; Fibroblast Growth Factor 2; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Neurons; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Time Factors | 2007 |
Dietary restriction enhances kainate-induced increase in NCAM while blocking the glial activation in adult rat brain.
Topics: Animals; Blotting, Western; Brain Stem; Caloric Restriction; Data Interpretation, Statistical; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Male; Neural Cell Adhesion Molecules; Neuroglia; Neuronal Plasticity; Rats; Rats, Wistar | 2008 |
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
Topics: Animals; Astrocytes; Cathepsins; Coloring Agents; Disease Models, Animal; Enzyme Activation; Epilepsy; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Kainic Acid; Lysosomes; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurotoxins; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Pyramidal Cells; Up-Regulation | 2007 |
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus.
Topics: Algorithms; Animals; Blood-Brain Barrier; Chlorides; Chronic Disease; Contrast Media; Data Interpretation, Statistical; Dentate Gyrus; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gadolinium; Gliosis; Kainic Acid; Magnetic Resonance Imaging; Male; Manganese Compounds; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2008 |
Gliosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity.
Topics: Animals; Astrocytes; Axons; Cell Death; Epilepsy; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Male; Neurons; Rats; Rats, Wistar; Tenascin | 1995 |
Periodic acid-Schiff (PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Mapping; Epilepsy; Extracellular Matrix; Gliosis; Immunohistochemistry; Kainic Acid; Male; Necrosis; Nerve Degeneration; Periodic Acid-Schiff Reaction; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Status Epilepticus | 1995 |
Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment.
Topics: Animals; Base Sequence; Blotting, Western; DNA; DNA-Binding Proteins; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Homeodomain Proteins; Immunohistochemistry; Kainic Acid; Male; Minor Histocompatibility Antigens; Molecular Sequence Data; Oligonucleotide Probes; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Replication Protein C; Repressor Proteins; Saccharomyces cerevisiae Proteins; Transcription Factors | 1994 |
Increased levels of nerve growth factor (NGF) protein and mRNA and reactive gliosis following kainic acid injection into the rat striatum.
Topics: Animals; Astrocytes; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Gene Expression; Glial Fibrillary Acidic Protein; Gliosis; Kainic Acid; Male; Microglia; Microinjections; Nerve Growth Factors; Neurons; Rats; Rats, Wistar; Reference Values; RNA, Messenger; Stereotaxic Techniques | 1994 |
Differential activation of microglia and astrocytes in aniso- and isomorphic gliotic tissue.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Cell Death; Frontal Lobe; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Hybridomas; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Microglia; Rats; Rats, Wistar; Vimentin | 1993 |
Induction of NF-kB-like transcription factors in brain areas susceptible to kainate toxicity.
Topics: Animals; Base Sequence; Biotransformation; Brain; Brain Chemistry; Cytoplasm; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Macrophage Activation; Male; Microglia; Molecular Sequence Data; Nerve Degeneration; NF-kappa B; Oligonucleotide Probes; Rats; Rats, Inbred F344 | 1996 |
Differential cellular response after glutamate analog hippocampal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biomarkers; Brain; Brain Injuries; Cerebral Cortex; Cerebral Ventricles; Corpus Callosum; Glial Fibrillary Acidic Protein; Gliosis; Glutamic Acid; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Microglia; Neurons; Rats; Rats, Wistar | 1996 |
Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; Excitatory Amino Acid Agonists; Gene Expression; Gliosis; HIV Envelope Protein gp120; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Neurons; Neurotoxins; RNA, Messenger; Transgenes | 1997 |
Temporal profiles of the in vitro phosphorylation rate and immunocontent of glial fibrillary acidic protein (GFAP) after kainic acid-induced lesions in area CA1 of the rat hippocampus: demonstration of a novel phosphoprotein associated with gliosis.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Kinetics; Male; Phosphoproteins; Phosphorylation; Rats; Rats, Wistar; Up-Regulation; Vimentin | 1997 |
Qualitative analysis of membrane currents in glial cells from normal and gliotic tissue in situ: down-regulation of Na+ current and lack of P2 purinergic responses.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Cicatrix; Electric Conductivity; Extracellular Space; Gliosis; Hippocampus; Kainic Acid; Neuroglia; Rats; Rats, Wistar; Receptors, Purinergic; Reference Values; Sodium | 1997 |
The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.
Topics: Adenosine; Animals; Body Temperature; Chlormethiazole; Dizocilpine Maleate; Drug Synergism; Drug Therapy, Combination; Entorhinal Cortex; Epilepsy, Tonic-Clonic; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; Gliosis; Hippocampus; Isoquinolines; Kainic Acid; Male; Muscimol; Neurons; Neuroprotective Agents; Neurotoxins; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Xanthines | 1997 |
Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Astrocytes; Brain Injuries; Brain Ischemia; Calcium Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gerbillinae; Glial Fibrillary Acidic Protein; Gliosis; Homeostasis; Hot Temperature; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Neurologic Mutants; Myelin Sheath; Rats; Up-Regulation; Wounds, Stab | 1998 |
Platelet activating factor receptor expression is associated with neuronal apoptosis in an in vivo model of excitotoxicity.
Topics: Animals; Apoptosis; Astrocytes; Cell Survival; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Platelet Membrane Glycoproteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Status Epilepticus; Transcription, Genetic | 1998 |
Independent mechanisms of potassium clearance by astrocytes in gliotic tissue.
Topics: Animals; Astrocytes; Biological Transport; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; In Vitro Techniques; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Potassium; Rats; Rats, Wistar | 1999 |
Expression of the thymosin beta10 gene in normal and kainic acid-treated rat forebrain.
Topics: Actins; Animals; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Gliosis; Hippocampus; In Situ Hybridization; Kainic Acid; Nerve Tissue Proteins; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thymosin | 1999 |
Overexpression of spermidine/spermine N-acetyltransferase in transgenic mice protects the animals from kainate-induced toxicity.
Topics: Acetylation; Acetyltransferases; Animals; Brain; Cell Count; Cerebral Cortex; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; In Situ Hybridization; Kainic Acid; Lethal Dose 50; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Polyamines; Putrescine; RNA, Messenger | 2000 |
Quantitative immunochemistry on neuronal loss, reactive gliosis and BBB damage in cortex/striatum and hippocampus/amygdala after systemic kainic acid administration.
Topics: Amygdala; Animals; Blood Proteins; Blood-Brain Barrier; Brain; Cell Death; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunochemistry; Kainic Acid; Male; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; S100 Proteins | 2000 |
Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures.
Topics: Amygdala; Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger | 2000 |
Distribution of hydroxynonenal-modified proteins in the kainate-lesioned rat hippocampus: evidence that hydroxynonenal formation precedes neuronal cell death.
Topics: Aldehydes; Animals; Cell Death; Gliosis; Hippocampus; Kainic Acid; Lipid Peroxides; Male; Microscopy, Immunoelectron; Nerve Tissue Proteins; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA | 2000 |
Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy.
Topics: Animals; Astrocytes; Brain; Cell Death; Electroencephalography; Entorhinal Cortex; Gliosis; Hippocampus; Humans; Kainic Acid; Medical Records; Necrosis; Neocortex; Neuroglia; Neurons; Pilocarpine; Rats; Status Epilepticus | 2000 |
Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Gliosis; Hippocampus; In Situ Nick-End Labeling; Interleukin-6; Kainic Acid; Macrophages; Metallothionein; Mice; Mice, Knockout; Microglia; Nerve Degeneration; Oxidative Stress; Seizures; Superoxide Dismutase | 2001 |
Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5.
Topics: Adaptation, Physiological; Animals; Astrocytes; Brain Injuries; COS Cells; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Nerve Degeneration; Nerve Regeneration; Neuronal Plasticity; Pyramidal Cells; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Up-Regulation | 2001 |
Rapid activation of microglial cells by hypoxia, kainic acid, and potassium ions in slice preparations of the rat hippocampus.
Topics: Action Potentials; Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Cell Size; Electric Stimulation; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Hypoxia, Brain; Immunohistochemistry; Kainic Acid; Macrophage-1 Antigen; Male; Membrane Glycoproteins; Microglia; Neurons; Potassium; Pyramidal Cells; Rats; Rats, Wistar | 2001 |
Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
Topics: Animals; Arginine; Astrocytes; Crystallins; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gliosis; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Indazoles; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Molecular Chaperones; Neoplasm Proteins; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Seizures | 2001 |
Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure.
Topics: Animals; Antibody Specificity; Astrocytes; Behavior, Animal; Cell Death; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Status Epilepticus | 2001 |
Systemic administration of kainic acid in adult rat stimulates expression of the chemokine receptor CCR5 in the forebrain.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Proteins; Brain Injuries; Chemokines; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Membrane Glycoproteins; Nerve Degeneration; Neuroglia; Neurons; Neurotoxins; Phosphopyruvate Hydratase; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, CCR5; RNA, Messenger; Up-Regulation | 2002 |
Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice.
Topics: Administration, Intranasal; Age Factors; Animals; Apoptosis; Behavior, Animal; Body Weight; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Isoenzymes; Kainic Acid; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons; Prostaglandin-Endoperoxide Synthases; Seizures; Survival Rate | 2002 |
Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration.
Topics: Animals; Biomarkers; Cell Death; Cell Division; Chemotaxis; Down-Regulation; Excitatory Amino Acid Agonists; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Mutant Strains; Microglia; Nerve Degeneration; Pyramidal Cells; Tissue Plasminogen Activator | 2002 |
A histological study of kainic acid-induced lesions in the rat brain.
Topics: Animals; Brain; Cerebral Cortex; Cerebral Ventricles; Corpus Striatum; Demyelinating Diseases; Gliosis; Hippocampus; Kainic Acid; Male; Motor Activity; Pyrrolidines; Rats | 1978 |
Increase in nucleoside diphosphatase in rat brain striatum lesioned with kainic acid.
Topics: Acid Anhydride Hydrolases; Ammonia; Animals; Brain; Corpus Striatum; Cycloheximide; Gliosis; Kainic Acid; Male; Phosphoric Monoester Hydrolases; Puromycin; Rats; Rats, Wistar | 1992 |
Serotonin uptake by astrocytes in situ.
Topics: Animals; Astrocytes; Brain Chemistry; Gliosis; Hippocampus; Immunohistochemistry; In Vitro Techniques; Injections, Intraventricular; Kainic Acid; Rats; Rats, Sprague-Dawley; Serotonin | 1992 |
Separate blood and brain origins of proliferating cells during gliosis in adult brains.
Topics: Animals; Astrocytes; Brain; Bromodeoxyuridine; Cell Division; Corpus Striatum; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Male; Mice; Thymidine | 1990 |
Systemic injection of kainic acid: gliosis in olfactory and limbic brain regions quantified with [3H]PK 11195 binding autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Gliosis; Injections, Intraperitoneal; Isoquinolines; Kainic Acid; Limbic System; Male; Olfactory Bulb; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1990 |
Long term sequelae of parenteral administration of kainic acid.
Topics: Amygdala; Animals; Brain; Cerebral Cortex; Epilepsy, Temporal Lobe; Gliosis; Hippocampus; Kainic Acid; Limbic System; Neuroglia; Rats; Sclerosis; Seizures; Thalamic Nuclei; Time Factors | 1986 |
Electrophysiology of epileptic tissue: what pathologies are epileptogenic?
Topics: Action Potentials; Animals; Cerebral Cortex; Epilepsy; Epilepsy, Temporal Lobe; Gliosis; Guinea Pigs; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Neural Inhibition | 1986 |
Effects of intrahypothalamic kainic acid injection on taurine levels, binding and uptake.
Topics: Animals; Binding Sites; Gliosis; Hypothalamus; Kainic Acid; Male; Nerve Endings; Neuroglia; Neurons, Afferent; Pyrrolidines; Rats; Rats, Inbred Strains; Taurine | 1985 |