kainic acid has been researched along with Acute Confusional Senile Dementia in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (16.67) | 18.7374 |
| 1990's | 24 (33.33) | 18.2507 |
| 2000's | 20 (27.78) | 29.6817 |
| 2010's | 13 (18.06) | 24.3611 |
| 2020's | 3 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Barthet, G; Castanheira, J; Deforges, S; Gorlewicz, A; Moreira-de-Sá, A; Mulle, C; Zhang, P | 1 |
| Chen, J; Duan, H; Geng, Z; Song, S; Wang, F; Wang, H; Xiao, P; Zhao, Y; Zhou, Y | 1 |
| Akarsu Egger, H; Auber, LA; Dreos, R; Falquet, L; Marathe, S; Perna, A | 1 |
| Banerjee, M; Hariharakrishnan, J; Kar, S; Kodam, A; Maulik, M; Ourdev, D; Wang, Y | 1 |
| Fritschy, JM; Gfeller, T; Gschwind, T; Knuesel, I; Lafourcade, C; Rambousek, L; Zaichuk, M | 1 |
| Cai, HY; Hu, MM; Kong, LL; Qi, JS; Wang, ZJ; Wu, MN; Zhang, J | 1 |
| Bouras, C; Fugistier, P; Leuba, G; Marin, P; Piotton, F; Savioz, A; Vallet, PG | 1 |
| Harrison, FE; Kang, JQ; Kennard, JA; Warner, TA | 1 |
| Cao, M; Ding, F; Gong, CX; Gu, X; Iqbal, K; Jin, N; Liu, F; Yin, X; Yu, D | 1 |
| Cook, A; DiMaio, J; Johnson, GVW; Nilsson, B; Pallo, SP | 1 |
| Dawson, HN; Fan, Q; Ghosal, K; Pimplikar, SW | 1 |
| Raymick, J; Schmued, L | 1 |
| Akatsu, H; Hashizume, Y; Ikegami, K; Setou, M; Vu, HT | 1 |
| Jovicić, ME; Nesić, KJ; Pavlović, SJ; Popović, M; Popović, N; Rakić, L | 1 |
| Craig, LA; Hong, NS; Kopp, J; McDonald, RJ | 1 |
| Campbell, J; Cataldo, AM; Chen, Y; Haroutunian, V; Jiang, Y; Mohan, PS; Nixon, RA; Paskevich, PA; Peterhoff, CM; Rao, MV; Schmidt, SD; Stavrides, PH; Yang, DS | 1 |
| Ando, K; Higuchi, M; Inaji, M; Ji, B; Lee, VM; Maeda, J; Okauchi, T; Ono, M; Sawada, M; Staufenbiel, M; Suhara, T; Suzuki, K; Trojanowski, JQ; Zhang, MR | 1 |
| Gunther, T; Hüll, M; Schüle, R; Schulte, EC; Slawik, H | 1 |
| Farooqui, AA | 1 |
| Adaya-Villanueva, A; Balleza-Tapia, H; Márquez-Ramos, A; Ordaz, B; Peña-Ortega, F | 1 |
| Joo, SS; Kang, H; Kim, SU; Kim, TK; Kim, YB; Lee, HJ; Lee, SH; Lim, I; Matsuo, A; Park, D; Tooyama, I | 1 |
| Dang, T; Kaye, JA; Milatovic, D; Montine, TJ; Morrow, JD; Quinn, JF; Roberts, LJ; Sanchez, S; Silbert, LC; Terry, E | 1 |
| Cao, DL; Chen, JP; Tu, XW; Yuan, DJ; Zhou, SL | 1 |
| Du, XP; Li, M; Ye, H | 1 |
| Farooqui, AA; Horrocks, LA; Ong, WY | 1 |
| De Mello, FG; Ferreira, ST; Louzada, PR; Mendonca-Silva, DL; Noël, F; Paula Lima, AC | 1 |
| Brecht, WJ; Buttini, M; Chang, S; Dee Fish, J; Harris, FM; Huang, Y; Mahley, RW; Mucke, L; Tesseur, I; Wyss-Coray, T; Xu, Q; Yu, GQ | 1 |
| Chen, K; Muller, M; Zeng, L; Zhou, MM | 1 |
| Berezov, T; Boldyrev, A; Carpenter, DO; Koudinov, A | 1 |
| Arai, H; Higuchi, M; Iwata, N; Maruyama, M; Matsuba, Y; Matsui, T; Mizukami, H; Muramatsu, S; Nemoto, M; Ozawa, K; Saido, TC; Sasaki, H; Takaki, Y; Tanji, H; Tomita, N | 1 |
| Bernareggi, A; Dueñas, Z; Miledi, R; Reyes-Ruiz, JM; Ruzzier, F | 1 |
| Arias, C; Ferrera, P; Hernández-Ortega, K | 1 |
| Cheng, IH; Gerstein, H; Mucke, L; Palop, JJ; Roberson, ED; Scearce-Levie, K; Wu, T; Yan, F; Yu, GQ | 1 |
| Benson, DM; Ksir, C | 1 |
| Bowen, DM; Pearce, BR | 1 |
| Friedman, E; Kuster, J; Lerer, B | 1 |
| Crow, TJ; Mashal, RD; Owen, F; Poulter, M; Waddington, JL | 1 |
| Choi, D; Gottron, F; Turetsky, D | 1 |
| Choi, DW; Weiss, JH; Yin, HZ | 1 |
| Edwards, AM; Heinemann, SF; Huntley, GW; Moran, T; Morrison, JH; Rogers, SW; Vickers, JC | 1 |
| Angeretti, N; Forloni, G; Smiroldo, S | 1 |
| Larner, AJ | 1 |
| Alonso, R; Beffert, U; Boksa, P; Dea, D; O'Donnell, D; Poirier, J | 1 |
| Aisen, PS; Freire-Moar, J; Pasinetti, GM; Sakhi, SH; Schreiber, SS; Tocco, G | 1 |
| Ebstein, RP; Shoham, S | 1 |
| Garrido, JJ; Salinero, O; Wandosell, F | 1 |
| Panegyres, PK | 1 |
| Clarke, EE; Gervais, FG; Huang, J; LeBlanc, A; Nicholson, DW; Rigby, M; Robertson, GS; Roy, S; Ruffolo, SC; Shearman, MS; Smith, D; Thornberry, NA; Vaillancourt, JP; Van Der Ploeg, LH; Xanthoudakis, S; Xu, D; Zamboni, RJ; Zheng, H; Zhu, Y | 1 |
| Aisen, PS; Mukherjee, P; Osaka, H; Pasinetti, GM | 1 |
| Akeefe, H; Bellosta, S; Buttini, M; Mahley, RW; Mucke, L; Orth, M; Pitas, RE; Wyss-Coray, T | 1 |
| Guo, Q; Mattson, MP; Zhu, H | 1 |
| Ceuterick, C; Checler, F; Cordell, B; Cras, P; De Jonghe, C; Dewachter, I; Kumar-Singh, S; Lübke, U; Moechars, D; Naidu, A; Van Broeckhoven, C; Van Leuven, F | 1 |
| Li, L | 1 |
| Brusa, R; Casarini, M; Diodato, E; Grilli, M; Lozza, G; Memo, M; Ongini, E; Rozmahel, R; St George-Hyslop, P; Uberti, D; Westaway, D | 1 |
| An, X; Li, L; Qiao, J | 1 |
| Hu, GY; Zhang, JM | 1 |
| Brunner, LC; Choe, W; Cotman, CW; Geddes, JW; Ułas, J | 1 |
| Dahlström, A; Ling, EA; McRae, A; Nee, LE; Polinsky, RJ | 1 |
| Klunk, WE; McClure, RJ; Pettegrew, JW | 1 |
| Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J | 1 |
| Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J; Shand, A | 1 |
| Brooks, DN; Chalmers, DT; Dewar, D; Graham, DI; McCulloch, J | 1 |
| Debowey, DL; Greenamyre, JT; Hollingsworth, Z; Maragos, WF; Penney, JB; Young, AB | 1 |
| Cotman, CW; Koh, JY; Yang, LL | 1 |
| Briggs, RS; Cowburn, RF; Hardy, JA; Roberts, PJ | 1 |
| Cotman, CW; Geddes, JW | 1 |
| Ben-Ari, Y; Duyckaerts, C; Hauw, JJ; Represa, A; Tremblay, E | 2 |
| Beninger, RJ; Boegman, RJ; Coloma, F; el-Defrawy, SR; Jhamandas, K; Wirsching, BA | 1 |
| Go, KG; Gramsbergen, JB; Korf, J; Prenen, GH | 1 |
| Björklund, A; Isacson, O; Sofroniew, MV | 1 |
| Chui, HC; Cotman, CW; Geddes, JW; Kim, RC; Lott, IT; Monaghan, DT | 1 |
4 review(s) available for kainic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Studies on plasmalogen-selective phospholipase A2 in brain.
Topics: Alzheimer Disease; Animals; Brain; Cattle; Cells, Cultured; Detergents; Excitatory Amino Acid Agonists; Humans; Kainic Acid; Lipids; Neurons; Octoxynol; Phospholipases A2; Plasmalogens | 2010 |
Plasmalogens, docosahexaenoic acid and neurological disorders.
Topics: Alzheimer Disease; Animals; Brain; Docosahexaenoic Acids; Enzyme Inhibitors; Fatty Acids, Unsaturated; Gene Expression Regulation; Humans; Kainic Acid; Nervous System Diseases; Peroxisomal Disorders; Phospholipases A; Phospholipases A2; Plasmalogens | 2003 |
Axonal sprouting and synaptogenesis in temporal lobe epilepsy: possible pathogenetic and therapeutic roles of neurite growth inhibitory factors.
Topics: Alzheimer Disease; Animals; Axons; Brain; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Nerve Growth Factors; Neuronal Plasticity; Rats; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Synapses | 1995 |
Cation shifts and excitotoxins in Alzheimer and Huntington disease and experimental brain damage.
Topics: Aged; Alzheimer Disease; Amino Acids; Animals; Brain; Brain Diseases; Calcium; Cations; gamma-Aminobutyric Acid; Humans; Huntington Disease; Kainic Acid; Middle Aged; Neurotoxins; Tetrodotoxin | 1986 |
68 other study(ies) available for kainic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Presenilin and APP Regulate Synaptic Kainate Receptors.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Female; GluK2 Kainate Receptor; Kainic Acid; Male; Mice; Mossy Fibers, Hippocampal; Presenilin-1; Presenilins; Receptors, Kainic Acid; Synapses | 2022 |
Role of Macrophages in Status Epilepticus Predisposing to Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; CA3 Region, Hippocampal; Convulsants; Female; Kainic Acid; Macrophages; Microinjections; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptor, Macrophage Colony-Stimulating Factor; Seizures; Signal Transduction; Status Epilepticus | 2020 |
Revealing NOTCH-dependencies in synaptic targets associated with Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Hippocampus; Humans; Kainic Acid; Mice; Nerve Tissue Proteins; Neuroprotective Agents; Receptor, Notch1; Receptors, Cell Surface | 2021 |
A role for astrocyte-derived amyloid β peptides in the degeneration of neurons in an animal model of temporal lobe epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2019 |
Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; Mice, Transgenic; Neuronal Plasticity; Seizures; Status Epilepticus | 2018 |
Amyloid β protein injection into medial septum impairs hippocampal long-term potentiation and cognitive behaviors in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Hippocampus; Kainic Acid; Long-Term Potentiation; Maze Learning; Memory Disorders; Neuronal Plasticity; Peptide Fragments; Rats; Spatial Learning; Spatial Memory | 2018 |
Comparison of frailty of primary neurons, embryonic, and aging mouse cortical layers.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Okadaic Acid; Peptide Fragments; Plaque, Amyloid | 2014 |
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Brain; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Humans; Kainic Acid; Male; Malondialdehyde; Mice, Knockout; Mice, Transgenic; Oxidative Stress; Pentylenetetrazole; Presenilin-1; Seizures; Sodium-Coupled Vitamin C Transporters | 2015 |
Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Calcium; Calpain; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Kainic Acid; Male; Mice; Phosphorylation; Proteolysis; Recombinant Fusion Proteins; tau Proteins; Up-Regulation | 2015 |
Mechanisms of tau and Aβ-induced excitotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cerebral Cortex; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Neurons; Rats; Reactive Oxygen Species; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Seizures; Superoxides; tau Proteins | 2016 |
Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Female; Gene Expression; Gene Knockout Techniques; Humans; Kainic Acid; Lithium; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Transgenic; Neurogenesis; Neurons; Phenotype; Phosphorylation; Protein Interaction Domains and Motifs; Receptors, N-Methyl-D-Aspartate; Seizures; tau Proteins | 2016 |
Introducing Euro-Glo, a rare earth metal chelate with numerous applications for the fluorescent localization of myelin and amyloid plaques in brain tissue sections.
Topics: Alzheimer Disease; Animals; Brain; Chelating Agents; Coordination Complexes; Disease Models, Animal; Fluoresceins; Fluorescent Dyes; Kainic Acid; Mice, Transgenic; Myelin Sheath; Phenanthrolines; Phosphates; Plaque, Amyloid; Rats, Sprague-Dawley; Staining and Labeling | 2017 |
Increase in α-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cells, Cultured; Dendrites; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Neurons; Protein Processing, Post-Translational; Purkinje Cells; Seizures; Tubulin | 2017 |
Aging, aluminium and basal forebrain lesions modify substrate kinetics of erythrocyte membrane Na,K-ATPase in the rat.
Topics: Adenosine Triphosphate; Age Factors; Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Chlorides; Cholinergic Fibers; Disease Models, Animal; Erythrocyte Membrane; Injections, Intraventricular; Kainic Acid; Male; Potassium; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase; Substrate Specificity | 2008 |
Reduced cholinergic status in hippocampus produces spatial memory deficits when combined with kainic acid induced seizures.
Topics: Acetylcholine; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cholinergic Agents; Convulsants; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Memory Disorders; Rats; Rats, Long-Evans; Ribosome Inactivating Proteins, Type 1; Risk Factors; Saporins; Seizures; Spatial Behavior | 2008 |
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Calcium-Binding Proteins; Calpain; Case-Control Studies; Caspases; Cell Death; Cell Line, Transformed; Cytoskeleton; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation; Hippocampus; Humans; Kainic Acid; Male; Mice; Mice, Transgenic; Middle Aged; Nerve Degeneration; Postmortem Changes; RNA, Small Interfering; Transfection | 2008 |
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cell Line, Transformed; Cell Transplantation; Central Nervous System; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurotoxicity Syndromes; Oxidopamine; Phenyl Ethers; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, GABA-A; tau Proteins | 2008 |
Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Blotting, Western; Cyclooxygenase 1; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Humans; Injections, Intraperitoneal; Kainic Acid; Mice; Mice, Transgenic; Presenilin-2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Receptors, Prostaglandin E; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2009 |
Beta-like hippocampal network activity is differentially affected by amyloid beta peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Electrochemical Techniques; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Nerve Net; Osmolar Concentration; Peptide Fragments; Perfusion; Potassium; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals.
Topics: Acetylcholine; Alzheimer Disease; Animals; Astrocytes; CA3 Region, Hippocampal; Choline O-Acetyltransferase; Cognition Disorders; Disease Models, Animal; Humans; Kainic Acid; Learning; Male; Memory Disorders; Neural Stem Cells; Neurogenesis; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation | 2012 |
Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Biomarkers; Brain; F2-Isoprostanes; Humans; Kainic Acid; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reference Values | 2002 |
[Effects of basic fibroblast growth factor on rat models of Alzheimer disease].
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Disease Models, Animal; Fibroblast Growth Factor 2; Kainic Acid; Learning; Male; Memory; Rats; Rats, Sprague-Dawley | 2003 |
[Protective effect of Polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats].
Topics: Alzheimer Disease; Animals; Cholinergic Fibers; Drugs, Chinese Herbal; Kainic Acid; Male; Neuroprotective Agents; Polygonum; Prosencephalon; Rats; Rats, Sprague-Dawley | 2003 |
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Cellular Senescence; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Eye Proteins; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Picrotoxin; Receptors, AMPA; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Retina; Taurine | 2004 |
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Topics: Aging; Alzheimer Disease; Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Astrocytes; Brain; Brain Chemistry; Female; Gene Targeting; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Mice; Mice, Transgenic; Neurons; Neurotoxins; Peptide Fragments; Phosphopyruvate Hydratase; Phosphorylation; Promoter Regions, Genetic; tau Proteins | 2004 |
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors.
Topics: Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Brain; Drug Design; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ion Channels; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Molecular Conformation; Neuroprotective Agents; Protein Structure, Tertiary; Receptors, AMPA | 2004 |
Amyloid-beta induced cell death is independent of free radicals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Animals, Newborn; Calcium; Carnosine; Cell Death; Cell Survival; Cerebellum; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Dyes; Free Radicals; Indicators and Reagents; Intracellular Space; Kainic Acid; N-Methylaspartate; Neurons; Propidium; Rats; Reactive Oxygen Species; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xanthenes | 2004 |
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Biomarkers; Down-Regulation; Early Diagnosis; Excitatory Amino Acid Agonists; Female; Genetic Vectors; Hippocampus; Humans; Kainic Acid; Male; Mice; Neprilysin; Rats | 2005 |
Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes.
Topics: Alzheimer Disease; Animals; Anura; Benzothiadiazines; Blotting, Western; Brain Tissue Transplantation; Cell Membrane; Cerebral Cortex; Electric Conductivity; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Humans; Kainic Acid; Oocytes; Protein Subunits; Receptors, GABA; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
Sequential expression of cell-cycle regulators and Alzheimer's disease-related proteins in entorhinal cortex after hippocampal excitotoxic damage.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Biomarkers; Cell Cycle; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cyclins; Dentate Gyrus; Entorhinal Cortex; Epitopes; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Phosphorylation; Rats; Rats, Wistar; tau Proteins; Time Factors | 2007 |
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Axons; Convulsants; Disease Models, Animal; Excitatory Amino Acid Agonists; Exploratory Behavior; Hippocampus; Humans; Kainic Acid; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Phosphorylation; Seizures; tau Proteins | 2007 |
Enhanced behavioral response to nicotine in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Dextroamphetamine; Disease Models, Animal; Humans; Kainic Acid; Male; Motor Activity; Nicotine; Rats | 1983 |
[3H]Kainic acid binding and choline acetyltransferase activity in Alzheimer's dementia.
Topics: Adult; Aged; Alzheimer Disease; Binding Sites; Caudate Nucleus; Choline O-Acetyltransferase; Female; Humans; Kainic Acid; Male; Middle Aged; Nerve Tissue Proteins; Pyrrolidines | 1984 |
Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning.
Topics: Acetylcholine; Alzheimer Disease; Animals; Avoidance Learning; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Humans; Kainic Acid; Male; Memory; Models, Neurological; Neurons; Rats; Rats, Inbred Strains; Tissue Distribution | 1983 |
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Animals; Benzodiazepinones; Binding Sites; Corpus Striatum; Female; Flunitrazepam; Glutamate Decarboxylase; Humans; Kainic Acid; Male; Pyrrolidines; Rats; Temporal Lobe; Tritium | 1983 |
SMI-32 antibody against non-phosphorylated neurofilaments identifies a subpopulation of cultured cortical neurons hypersensitive to kainate toxicity.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Cell Death; Cells, Cultured; Cerebral Cortex; Huntington Disease; Hypersensitivity; Immunohistochemistry; Kainic Acid; Mice; Mice, Inbred Strains; Neurofilament Proteins; Neurons | 1995 |
Basal forebrain cholinergic neurons are selectively vulnerable to AMPA/kainate receptor-mediated neurotoxicity.
Topics: Acetylcholine; Acetylcholinesterase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Choline O-Acetyltransferase; Kainic Acid; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Prosencephalon; Receptors, AMPA; Receptors, Kainic Acid | 1994 |
Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Antibodies; Biomarkers; Epitopes; Humans; Ibotenic Acid; Immunohistochemistry; Kainic Acid; Macaca fascicularis; Macromolecular Substances; Nerve Tissue Proteins; Neurons; Prefrontal Cortex; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Neuroprotective activity of acetyl-L-carnitine: studies in vitro.
Topics: Acetylcarnitine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood Physiological Phenomena; Cattle; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; N-Methylaspartate; Neurons; Peptide Fragments; Rats | 1994 |
Increased levels of statin, a marker of cell cycle arrest, in response to hippocampal neuronal injury.
Topics: Alzheimer Disease; Animals; Biomarkers; Cell Cycle; Cell Cycle Proteins; Cell Death; Entorhinal Cortex; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Peptide Elongation Factor 1; Proteins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1995 |
Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amygdala; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Hippocampus; Isoenzymes; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Organ Specificity; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1997 |
The distribution of beta-amyloid precursor protein in rat cortex after systemic kainate-induced seizures.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain Chemistry; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Microglia; Nerve Tissue Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seizures; Synaptic Transmission | 1997 |
Amyloid precursor protein proteoglycan is increased after brain damage.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antibody Specificity; Brain; Chondroitin Sulfate Proteoglycans; Immune Sera; Immunoglobulin G; Injections, Intraventricular; Kainic Acid; Male; Peptide Fragments; Rats; Rats, Wistar; Stereotaxic Techniques | 1998 |
The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; Brain; Dizocilpine Maleate; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Male; Neuroprotective Agents; Neurotoxins; Organ Specificity; Pentobarbital; Pentylenetetrazole; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic; Trypsin Inhibitor, Kunitz Soybean | 1998 |
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Topics: Acute Disease; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Amyloidosis; Animals; Apoptosis; Aspartic Acid; Aspartic Acid Endopeptidases; Brain Diseases; Camptothecin; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Inhibitors; Enzyme Precursors; Excitatory Amino Acid Agonists; Hippocampus; Humans; In Situ Nick-End Labeling; Kainic Acid; Leukemia, Erythroblastic, Acute; Male; Mice; Mice, Inbred C57BL; Mutation; Neurons; Oligopeptides; Rabbits; Rats; Rats, Wistar; Sweden; Tumor Cells, Cultured | 1999 |
Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity.
Topics: Alzheimer Disease; Animals; Blotting, Northern; Brain; Brain Diseases; Caspase 3; Caspases; Cells, Cultured; Complement C5a; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Mice; Neurotoxins; Recombinant Proteins; Time Factors | 1999 |
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
Topics: Aging; Alzheimer Disease; Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain Chemistry; Dendrites; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Genotype; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Presynaptic Terminals; RNA, Messenger; Synaptophysin | 1999 |
Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.
Topics: Alzheimer Disease; Animals; Body Weight; Cell Death; Diet; Eating; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Lipid Peroxidation; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Presenilin-1 | 1999 |
Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.
Topics: Aggression; Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Brain; Cell Nucleus; Cerebral Amyloid Angiopathy; Humans; Kainic Acid; Lethal Dose 50; Mice; Mice, Inbred Strains; Mice, Transgenic; N-Methylaspartate; Point Mutation | 2000 |
[An animal model of non-hereditary Alzheimer's disease and its behavioral and pathologic changes].
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Basal Nucleus of Meynert; Disease Models, Animal; Kainic Acid; Prefrontal Cortex; Rats | 1997 |
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Topics: Alzheimer Disease; Animals; Brain; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Agonists; Gene Expression; Humans; Infarction, Middle Cerebral Artery; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Presenilin-1 | 2000 |
Pathological characteristic of Alzheimer's disease produced by lesion in nucleus basalis of Meynert in rats.
Topics: Alzheimer Disease; Animals; Basal Nucleus of Meynert; Female; Hippocampus; Kainic Acid; Male; Maze Learning; Plaque, Amyloid; Rats | 1998 |
Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Hydrogen-Ion Concentration; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Nootropic Agents; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sesquiterpenes; Spermine; Zinc | 2001 |
Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Calcium; Female; Hippocampus; Humans; Kainic Acid; Kinetics; Male; Neurites; Neurofibrillary Tangles; Neurons; Oxadiazoles; Pyramidal Tracts; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reference Values; Tritium | 1992 |
Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain Injuries; Freezing; Immunohistochemistry; Kainic Acid; Macrophages; Male; Microscopy, Immunoelectron; Neuroglia; Rats; Rats, Wistar | 1992 |
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; Kainic Acid; N-Methylaspartate; Phosphoserine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Benzoxazines; Binding Sites; Female; Glutamates; Hippocampus; Humans; Ibotenic Acid; Kainic Acid; Male; Neurons; Oxazines | 1991 |
Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Autoradiography; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Receptors, AMPA; Receptors, Neurotransmitter | 1990 |
Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Aspartic Acid; Autoradiography; Cerebral Cortex; Female; Glutamates; Humans; Ibotenic Acid; Kainic Acid; Male; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Tritium | 1990 |
Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias.
Topics: Alzheimer Disease; Analysis of Variance; Dementia; Glutamates; Hippocampus; Humans; Kainic Acid; Phencyclidine; Receptors, GABA-A; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Regression Analysis | 1990 |
Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Neurotoxins | 1990 |
Characterisation, density, and distribution of kainate receptors in normal and Alzheimer's diseased human brain.
Topics: Adult; Aged; Alzheimer Disease; Brain; Humans; Kainic Acid; Kinetics; Male; Middle Aged; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
[Is Alzheimer's senile dementia associated with the phenomena of reactive synaptogenesis in the hippocampus?].
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Middle Aged; Neuronal Plasticity; Receptors, Neurotransmitter | 1988 |
Is senile dementia of the Alzheimer type associated with hippocampal plasticity?
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Middle Aged; Neuronal Plasticity | 1988 |
Functional and neurochemical cortical cholinergic impairment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Basal Ganglia; Cerebral Cortex; Choline; Cholinergic Fibers; In Vitro Techniques; Kainic Acid; Male; Neural Pathways; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substantia Innominata | 1985 |
Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Disease Models, Animal; Fetus; Glutamate Decarboxylase; Kainic Acid; Rats; Substantia Innominata | 1986 |
Plasticity of hippocampal circuitry in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Hippocampus; Humans; Kainic Acid; Male; Neuronal Plasticity; Neurons; Rats; Rats, Inbred Strains | 1985 |