kaempferol and Colonic-Neoplasms

kaempferol has been researched along with Colonic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for kaempferol and Colonic-Neoplasms

Article	Year
Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study. Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8 A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A- and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. With respect to structural modification of flavonoids, C-isoprenylation was by far the most effective, with substitution at the 8-position and longer chains, such as geranyl giving the best results. Finally, most compounds that significantly reduced cell survival also increased caspase activity, suggesting that at least part of their antiproliferative activity might be attributable to an apoptotic response. Topics: Alkylation; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Chalcone; Colonic Neoplasms; Enzyme Activators; Flavones; Flavonoids; Humans; Hydroxylation; Structure-Activity Relationship	2005
New bioactive polyphenols from Theobroma grandiflorum ("cupuaçu"). Journal of natural products, 2003, Volume: 66, Issue:11 Activity-guided fractionation of Theobroma grandiflorum ("cupuaçu") seeds resulted in the identification of two new sulfated flavonoid glycosides, theograndins I (1) and II (2). In addition, nine known flavonoid antioxidants, (+)-catechin, (-)-epicatechin, isoscutellarein 8-O-beta-d-glucuronide, hypolaetin 8-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide 6' '-methyl ester, quercetin, kaempferol, and isoscutellarein 8-O-beta-d-glucuronide 6' '-methyl ester, were identified. Theograndin II (2) displayed antioxidant activity (IC(50) = 120.2 microM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay, as well as weak cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 143 and 125 microM, respectively. While 1 was less active as an antioxidant than 2, the known compounds were more potent in the DPPH assay (IC(50) range 39.7-89.7 microM). Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Biphenyl Compounds; Catechin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Flavonoids; French Guiana; Glycosides; Humans; Inhibitory Concentration 50; Malvaceae; Molecular Structure; Picrates; Seeds; Tumor Cells, Cultured	2003

Article

Year

Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study.

Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8

A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A- and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. With respect to structural modification of flavonoids, C-isoprenylation was by far the most effective, with substitution at the 8-position and longer chains, such as geranyl giving the best results. Finally, most compounds that significantly reduced cell survival also increased caspase activity, suggesting that at least part of their antiproliferative activity might be attributable to an apoptotic response.

Topics: Alkylation; Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Chalcone; Colonic Neoplasms; Enzyme Activators; Flavones; Flavonoids; Humans; Hydroxylation; Structure-Activity Relationship

2005

New bioactive polyphenols from Theobroma grandiflorum ("cupuaçu").

Journal of natural products, 2003, Volume: 66, Issue:11

Activity-guided fractionation of Theobroma grandiflorum ("cupuaçu") seeds resulted in the identification of two new sulfated flavonoid glycosides, theograndins I (1) and II (2). In addition, nine known flavonoid antioxidants, (+)-catechin, (-)-epicatechin, isoscutellarein 8-O-beta-d-glucuronide, hypolaetin 8-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide 6' '-methyl ester, quercetin, kaempferol, and isoscutellarein 8-O-beta-d-glucuronide 6' '-methyl ester, were identified. Theograndin II (2) displayed antioxidant activity (IC(50) = 120.2 microM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay, as well as weak cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 143 and 125 microM, respectively. While 1 was less active as an antioxidant than 2, the known compounds were more potent in the DPPH assay (IC(50) range 39.7-89.7 microM).

Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Biphenyl Compounds; Catechin; Colonic Neoplasms; Drug Screening Assays, Antitumor; Flavonoids; French Guiana; Glycosides; Humans; Inhibitory Concentration 50; Malvaceae; Molecular Structure; Picrates; Seeds; Tumor Cells, Cultured

2003