kaempferol-3-o-rhamnoside has been researched along with Pneumonia* in 1 studies
1 other study(ies) available for kaempferol-3-o-rhamnoside and Pneumonia
Article | Year |
---|---|
Flavonoids from the aerial parts of Houttuynia cordata attenuate lung inflammation in mice.
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders. Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Epithelial Cells; Flavonoids; Houttuynia; Humans; Interleukin-6; Lipopolysaccharides; Macrophages, Alveolar; Male; Mannosides; Mice; Nitric Oxide; Phytotherapy; Plant Components, Aerial; Plant Extracts; Pneumonia; Proanthocyanidins; Quercetin | 2015 |