k-strophanthin-beta and Cardiomyopathies

Three cases of diabetic myocardiopathy having history of diabetes, angina and left ventricular dysfunction of various degrees and confirmed by coronary angiography and endomyocardial biopsy were reported. Electrocardiography showed significant ST-T changes simulating coronary insufficiency but without definite localization. As to the treatment, nitrate preparations, inotropic agents such as strophanthin K, digoxin etc. were used to relieve the symptoms; insulin was also administered to control the blood glucose level. Diltiazem, a calcium blocker, is also of help in alleviating the symptoms. It is shown in the present study and in the literatures as well that diabetic myocardiopathy is a disease showing intramural microvascular endothelial proliferation and swelling as well as subendothelial accumulation of acid glycogen deposition cells. The transportation of intracellular calcium ions and the cellular metabolism are thus affected, so there are extensive ischemia, focal necrosis and fibrosis in the myocardium with resulting cardiac dysfunction. The authors are, therefore, of the opinion that diabetic myocardiopathy is a specific and separate clinical entity.

Topics: Aged; Angina Pectoris; Cardiomyopathies; Diabetes Complications; Digoxin; Female; Humans; Male; Middle Aged; Strophanthins; Ventricular Function, Left

Topics: Adult; Aged; Cardiomyopathies; Doxorubicin; Female; Heart; Heart Function Tests; Humans; Isometric Contraction; Leukemia; Lymphoma; Male; Middle Aged; Rest; Strophanthins; Vitamin E

Topics: Aged; Cardiomyopathies; Disease; Heart Diseases; Humans; Myocardium; para-Aminobenzoates; Sclerosis; Strophanthins