jwh-210 and Substance-Related-Disorders

jwh-210 has been researched along with Substance-Related-Disorders* in 4 studies

Other Studies

4 other study(ies) available for jwh-210 and Substance-Related-Disorders

ArticleYear
Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
    International journal of molecular sciences, 2021, Sep-28, Volume: 22, Issue:19

    Interaction of cannabinoid receptor type 1 (CB1) and GABAergic neuronal activity is involved in drug abuse-related behavior. However, its role in drug-dependent Pavlovian conditioning is not well understood. In this study, we aimed to evaluate the effects of a CB1 agonist, JWH-210, on the development of conditioned place preference (CPP)-induced by methamphetamine (METH). Pretreatment with a synthetic cannabinoid, JWH-210 (CB1 agonist), increased METH-induced CPP score and METH-induced dopamine release in acute striatal slices. Interestingly, CB1 was expressed in glutamate decarboxylase 67 (GAD67) positive cells, and overexpression of CB1 increased GAD67 expression, while CB1 knockdown reduced GAD67 expression in vivo and in vitro. GAD67 is known as an enzyme involved in the synthesis of GABA. CB1 knockdown in the mice striatum increased METH-induced CPP. When GAD67 decreased in the mice striatum, mRNA level of

    Topics: Animals; Apomorphine; Corpus Striatum; Dopaminergic Neurons; Gene Expression Regulation, Enzymologic; Gene Knockdown Techniques; Glutamate Decarboxylase; Humans; Indoles; Male; Methamphetamine; Mice; Naphthalenes; Receptor, Cannabinoid, CB1; Substance-Related Disorders

2021
Mixed consumption of cannabis and "Spice".
    Forensic science international, 2014, Volume: 235

    Topics: Automobile Driving; Cannabinoids; Chromatography, Liquid; Designer Drugs; Forensic Toxicology; Germany; Humans; Indoles; Naphthalenes; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry

2014
Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds.
    Forensic science international, 2013, Dec-10, Volume: 233, Issue:1-3

    New designer drugs such as K2, Spice, and "bath salts" present a formidable challenge for law enforcement and public health officials. The following report summarizes a three-year study of 1320 law enforcement cases involving over 3000 products described as vegetable material, powders, capsules, tablets, blotter paper, or drug paraphernalia. All items were seized in Arkansas from January 2010 through December 2012 and submitted to the Arkansas State Crime Laboratory for analysis. The geographical distribution of these seizures co-localized in areas with higher population, colleges, and universities. Validated forensic testing procedures confirmed the presence of 26 synthetic cannabinoids, 12 designer stimulants, and 5 hallucinogenic-like drugs regulated by the Synthetic Drug Prevention Act of 2012 and other state statutes. Analysis of paraphernalia suggests that these drugs are commonly used concomitantly with other drugs of abuse including marijuana, MDMA, and methamphetamine. Exact designer drug compositions were unpredictable and often formulated with multiple agents, but overall, the synthetic cannabinoids were significantly more prevalent than all the other designer drugs detected. The synthetic cannabinoids JWH-018, AM2201, JWH-122, JWH-210, and XLR11 were most commonly detected in green vegetable material and powder products. The designer stimulants methylenedioxypyrovalerone (MDPV), 3,4-methylenedioxy-N-methylcathinone (methylone), and α-methylamino-valerophenone (pentedrone) were commonly detected in tablets, capsules, and powders. Hallucinogenic drugs were rarely detected, but generally found on blotter paper products. Emerging designer drug products remain a significant problem and continued surveillance is needed to protect public health.

    Topics: Benzodioxoles; Cannabinoids; Capsules; Central Nervous System Stimulants; Designer Drugs; Dronabinol; Hallucinogens; Humans; Indoles; Methamphetamine; Methylamines; Molecular Structure; Naphthalenes; Paper; Pentanones; Powders; Pyrrolidines; Substance-Related Disorders; Synthetic Cathinone; Tablets

2013
Identification and structural elucidation of four cannabimimetic compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in seized products.
    Journal of analytical toxicology, 2013, Volume: 37, Issue:2

    Since 2008, herbal mixtures with synthetic cannabinoid compounds have been sold as incense throughout the world. Although these new drugs are labeled as not for human consumption, these products are smoked for their cannabis-like effects. This study reports the structural and spectral elucidation of four cannabimimetic compounds seized in Belgium: (4-methoxyphenyl)-1-(pentyl-1H-indol-3-yl)methanone (RCS-4), 1-(5-fluoropentyl)-3-(1-naphtoyl)indole (AM-2201), 2-(2-chlorophenyl)-1-(1-pentylindol-3-yl)ethanone (JWH-203) and 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210). Laboratory investigations were conducted by liquid chromatography (LC)-ultraviolet spectroscopy, high-resolution accurate mass detection and nuclear magnetic resonance (NMR) analysis. This combined analytical approach allowed the detection of illicit compounds for which reference materials were not available. To facilitate identification and to complete existing databases, ultraviolet spectra and NMR data of all seized products are presented. Additionally, LC-quadrupole time-of-flight data were recorded to provide absolute identification.

    Topics: Cannabinoids; Chromatography, High Pressure Liquid; Forensic Sciences; Humans; Illicit Drugs; Indoles; Magnetic Resonance Spectroscopy; Molecular Structure; Naphthalenes; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Substance Abuse Detection; Substance-Related Disorders

2013
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