jsh-23 and Chronic-Disease

jsh-23 has been researched along with Chronic-Disease* in 2 studies

Reviews

1 review(s) available for jsh-23 and Chronic-Disease

ArticleYear
Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors.
    Journal of autoimmunity, 2020, Volume: 113

    Topics: Anaplastic Lymphoma Kinase; Animals; Anti-Inflammatory Agents; Chronic Disease; Disease Models, Animal; Diterpenes, Kaurane; Humans; Inflammasomes; Inflammation; Metabolic Diseases; Mice; NIMA-Related Kinases; NLR Family, Pyrin Domain-Containing 3 Protein; Phenylenediamines; Protein Binding; Protein Kinase Inhibitors; Up-Regulation

2020

Other Studies

1 other study(ies) available for jsh-23 and Chronic-Disease

ArticleYear
JSH-23 prevents depressive-like behaviors in mice subjected to chronic mild stress: Effects on inflammation and antioxidant defense in the hippocampus.
    Pharmacology, biochemistry, and behavior, 2018, Volume: 169

    Nuclear factor-kappa B (NF-κB), which is reported to play an important role in the pathogenesis of depression, also has a central role in the genesis and progression of inflammation. Here, we have targeted the nuclear translocation of NF-κB using 4-methyl-N1-(3-phenyl-propyl)-benzene-1,2-diamine (JSH-23) to elucidate its role in depression. We investigated the antidepressant-like effects of JSH-23 in the chronic mild stress (CMS) mouse model, which is a valid, reasonably reliable, and useful model of depression. The antidepressant-like effects of JSH-23 were evaluated using the sucrose preference test (SPT) and the forced swimming test (FST). We also assessed inflammatory markers [interleukin (IL)-6 and tumor necrosis factor-α (TNF-α)] and components of antioxidant defense [superoxide dismutase (SOD) and nuclear factor erythroid-2-related factor 2 (Nrf 2)] in the hippocampus. Fluoxetine, a classical antidepressant, was used in this study as a positive control. Administration of JSH-23 significantly prevented the decreased sucrose preference in the SPT and prevented the increased immobility time in the FST caused by CMS, but had no effect on locomotor activity. Expression of NF-κB p65 protein in the hippocampus was decreased, and elevated levels of IL-6 and TNF-α were reduced, after JSH-23 administration. In addition to its anti-inflammatory effect, JSH-23 treatment increased the expression of SOD and Nrf 2 in the hippocampus, suggesting that it strengthens antioxidant defense. The current study demonstrated that inhibiting the NF-κB signaling cascade using JSH-23 prevented depressive-like behaviors by decreasing inflammation and improving antioxidant defense in the hippocampus. We concluded that NF-κB activation plays an important role in the pathophysiology of depression and that targeting NF-κB signaling may provide a novel and effective therapy for depression. Additional preclinical studies and clinical trials are, however, needed to further elucidate the effects of this therapeutic strategy.

    Topics: Animals; Antioxidants; Biomarkers; Body Weight; Chronic Disease; Depression; Disease Models, Animal; Hippocampus; Inflammation; Interleukin-6; Locomotion; Male; Mice, Inbred C57BL; NF-kappa B; Phenylenediamines; Stress, Physiological; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2018