jq1-compound has been researched along with Triple-Negative-Breast-Neoplasms* in 2 studies
2 other study(ies) available for jq1-compound and Triple-Negative-Breast-Neoplasms
| Article | Year |
|---|---|
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carbolines; Cell Survival; Dose-Response Relationship, Drug; Drug Development; Drug Screening Assays, Antitumor; Humans; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Proteins; Structure-Activity Relationship; Triple Negative Breast Neoplasms | 2021 |
Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy.
Bromodomain-containing protein 4 (BRD4) is an attractive epigenetic target in human cancers. Inhibiting the phosphorylation of BRD4 by casein kinase 2 (CK2) is a potential strategy to overcome drug resistance in cancer therapy. The present study describes the synthesis of multiple BRD4-CK2 dual inhibitors based on rational drug design, structure-activity relationship, and Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Casein Kinase II; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Mice; Structure-Activity Relationship; Transcription Factors; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2021 |