jq1-compound and Inflammation

jq1-compound has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for jq1-compound and Inflammation

Article	Year
Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. European journal of medicinal chemistry, 2018, May-10, Volume: 151 A series of diverse small molecules have been designed and synthesized through structure-based drug design by taking advantage of fragment merging and elaboration approaches. Compounds ZL0420 (28) and ZL0454 (35) were identified as potent and selective BRD4 inhibitors with nanomolar binding affinities to bromodomains (BDs) of BRD4. Both of them can be well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H Topics: Animals; Anti-Inflammatory Agents; Cell Cycle Proteins; Cell Line; Drug Design; Humans; Immunity, Innate; Inflammation; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Nuclear Proteins; Respiratory Mucosa; Structure-Activity Relationship; Toll-Like Receptor 3; Transcription Factors	2018

Article

Year

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.

European journal of medicinal chemistry, 2018, May-10, Volume: 151

A series of diverse small molecules have been designed and synthesized through structure-based drug design by taking advantage of fragment merging and elaboration approaches. Compounds ZL0420 (28) and ZL0454 (35) were identified as potent and selective BRD4 inhibitors with nanomolar binding affinities to bromodomains (BDs) of BRD4. Both of them can be well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H

Topics: Animals; Anti-Inflammatory Agents; Cell Cycle Proteins; Cell Line; Drug Design; Humans; Immunity, Innate; Inflammation; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Nuclear Proteins; Respiratory Mucosa; Structure-Activity Relationship; Toll-Like Receptor 3; Transcription Factors

2018