jq1-compound and Colorectal-Neoplasms

Bromodomain-containing protein 4 (BRD4) and histone deacetylases (HDAC) are both attractive epigenetic targets in cancer and other chronic diseases. Based on the integrated fragment-based drug design, synthesis, and in vitro and in vivo evaluations, a series of novel thieno[2,3-

Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Male; Molecular Docking Simulation; Molecular Structure; Pyrimidines; Rats, Sprague-Dawley; Signal Transduction; Structure-Activity Relationship; Thiophenes; Transcription Factors; Xenograft Model Antitumor Assays; Zebrafish