jnj-7777120 and Dermatitis--Seborrheic

Previous studies have shown the expression of histamine H. This study aimed to investigate the role of H4R on these effector T cells in psoriasis.. We enrolled three patients each with active psoriasis, inactive psoriasis, scalp seborrheic dermatitis, and three normal controls, and compared the basal expression of H4R mRNA in their peripheral blood CD4. The results showed higher H4R expression in the active psoriasis group compared to the inactive psoriasis group. It was interesting that interleukin (IL)-23, which is a representative cytokine contributing to T. Histamine stimulation influences the IL-17 pathway in psoriasis via the fourth histamine receptor subtype, H4R, on CD4

Topics: Cell Separation; Dermatitis, Seborrheic; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Histamine; Humans; Indoles; Interleukin-17; Interleukin-23; Piperazines; Psoriasis; Receptors, Histamine H4; Recombinant Proteins; Signal Transduction; Th17 Cells