jnj-17203212 has been researched along with Hypothermia* in 1 studies
1 other study(ies) available for jnj-17203212 and Hypothermia
| Article | Year |
|---|---|
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
High throughput screening using the recombinant human TRPV1 receptor was used to identify a series of pyridinylpiperazine ureas (3) as TRPV1 vanilloid receptor ligands. Exploration of the structure-activity relationships by parallel synthesis identified the essential pharmacophoric elements for antagonism that permitted further optimization via targeted synthesis to provide a potent orally bioavailable and selective TRPV1 modulator 41 active in several in vivo models. Topics: Administration, Oral; Aminopyridines; Analgesics; Animals; Biological Availability; Body Temperature; Calcium; Capsaicin; Cell Line; Humans; Hypothermia; Ion Channels; Male; Pain Measurement; Piperazines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2005 |