jaw and Sepsis

The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation.

Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Enzyme Inhibitors; Female; Granulocytes; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Inflammation; Lung; Male; Mice; Mice, Inbred BALB C; Ovalbumin; p38 Mitogen-Activated Protein Kinases; Sepsis; Tumor Necrosis Factor-alpha