jasplakinolide has been researched along with Toxoplasmosis* in 2 studies
1 review(s) available for jasplakinolide and Toxoplasmosis
| Article | Year |
|---|---|
Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening.
Toxoplasma gondii severely threaten the health of immunocompromised patients and pregnant women as this parasite can cause several disease, including brain and eye disease. Current treatment for toxoplasmosis commonly have high cytotoxic side effects on host and require long durations ranging from one week to more than one year. The regiments lack efficacy to eradicate T. gondii tissue cysts to cure chromic infection results in the needs for long treatment and relapsing disease. In addition, there has not been approved drugs for treating the pregnant women infected by T. gondii. Moreover, Toxoplasma vaccine researches face a wide variety of challenges. Developing high efficient and low toxic agents against T. gondii is urgent and important. Over the last decade, tremendous progress have been made in identifying and developing novel compounds for the treatment of toxoplasmosis. This review summarized and discussed recent advances between 2009 and 2019 in exploring effective agents against T. gondii from five aspects of drug discovery. Topics: Animals; Antiprotozoal Agents; Drug Discovery; Female; Humans; Pregnancy; Toxoplasma; Toxoplasmosis | 2019 |
1 other study(ies) available for jasplakinolide and Toxoplasmosis
| Article | Year |
|---|---|
Aspects of the early moments of interaction between tachyzoites of Toxoplasma gondii with neutrophils.
The interaction of the tachyzoite stage of Toxoplasma gondii with neutrophils was investigated. Morphological aspects of the initial moments of interaction were analyzed by transmission and scanning electron microscopy, revealing at least three types of reaction from the leukocytes to the parasite: the projection of filopodia, formation of a tunnel-like projection involving the parasite, and invagination of the leukocyte surface at the point of entry. The influence on infectivity of tyrosine kinase, phosphokinase C and phosphatidylinositol 3 kinase cell signaling pathways were studied with the aid of drugs affecting these enzymes in these cells. Topics: Actins; Androstadienes; Animals; Depsipeptides; Enzyme Inhibitors; Genistein; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Naphthalenes; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Toxoplasma; Toxoplasmosis; Wortmannin | 2004 |