jasmonic-acid and Prostatic-Neoplasms

jasmonic-acid has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for jasmonic-acid and Prostatic-Neoplasms

ArticleYear
A new jasmonic acid stereoisomeric derivative induces apoptosis via reactive oxygen species in human prostate cancer cells.
    Cancer letters, 2012, Dec-30, Volume: 326, Issue:2

    With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of a (-)-jasmonic acid derivative, the 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid, obtained by biotransformation, on cell growth in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. The results obtained show that the new compound was able to inhibit the growth of both prostate cancer cells. In addition, our data seem to indicate that the apoptosis evocated by this new molecule, at least in part, appears to be associated with an increase of reactive oxygen species (ROS) production.

    Topics: Apoptosis; Cyclopentanes; Humans; Male; Oxylipins; Prostatic Neoplasms; Reactive Oxygen Species; Stereoisomerism

2012