itaconic acid has been researched along with Parkinson Disease in 2 studies
itaconic acid : A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we show that the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) orchestrates this defence response by scaffolding a complex between RAB32 and aconitate decarboxylase 1, which synthesizes itaconate from mitochondrial precursors." | 1.91 | Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella. ( Chen, M; Galán, JE; Lara-Tejero, M; Lian, H; Liu, J; Park, D; Schueder, F, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lian, H | 1 |
| Park, D | 1 |
| Chen, M | 1 |
| Schueder, F | 1 |
| Lara-Tejero, M | 1 |
| Liu, J | 1 |
| Galán, JE | 1 |
| Xia, N | 1 |
| Madore, V | 1 |
| Albalakhi, A | 1 |
| Lin, S | 1 |
| Stimpson, T | 1 |
| Xu, Y | 1 |
| Schwarzschild, MA | 1 |
| Bakshi, R | 1 |
2 other studies available for itaconic acid and Parkinson Disease
| Article | Year |
|---|---|
Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella.
Topics: Animals; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Parkinson Disease; Sal | 2023 |
Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson's disease.
Topics: Animals; Mice; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; P | 2023 |